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Ernst CM, Fischer LKS, Manson AL, Li L, Ma P, Anahtar MN, Bhattacharyya RP, Earl AM, Clatworthy AE, Hung DT

Klebsiella Brain Abscess and Evolution of Heterovirulence in the Urinary Tract.
N Engl J Med. 2026;395(4):408-410 - PMID: 42485633 - PMCID: PMC13403934 - DOI: 10.1056/NEJMc2108952

Weickert P, Liu Y, Strecker J

Prokaryotic Schlafen proteins cleave tRNAs during type III CRISPR immunity.
Nat Commun. 2026;:ePub - PMID: 42393087 - DOI: 10.1038/s41467-026-74880-6

Gomez JE, Solomon MY, Hunt DK, Geddes EJ, Bond AN, Liu C, Ulrich RJ, Chaudhary PV, Barkho S, Hung DT

Large-Scale Chemical-Genetic Interaction Profiling Identifies a Small-Molecule Inhibitor of Mycobacterium tuberculosis Polyketide Synthase 13.
ACS Infect Dis. 2026;12(6):2033-2045 - PMID: 42126262 - PMCID: PMC13271088 - DOI: 10.1021/acsinfecdis.6c00136

Clatworthy AE, DiNatale VP, Burgos-Robles E, Lopes F, Smillie C, Hung DT

Unravelling bacterial complexity at high resolution with single-cell transcriptomics.
Nat Microbiol. 2026;11(5):1168-1179 - PMID: 42067624 - DOI: 10.1038/s41564-026-02333-3

Antonova AU, Rodrigues PF, Mannie C, Ferrari G, Carvajal H, Bugatti M, Vermi W, Wu T, Cella M, Eghtesady P, Colonna M

Age- and tissue-dependent diversity of human plasmacytoid dendritic cells uncovers a cycling subset dominant in early life and cancer.
Immunity. 2026;59(5):1221-1236.e5 - PMID: 42061412 - PMCID: PMC13191660 - DOI: 10.1016/j.immuni.2026.04.003

Fachi JL, Trsan T, Sécca C, de Oliveira S, Rodovalho VR, Rodrigues PF, Beatty WL, Sudan R, Wu S, Bhattarai B, Panda SK, Cella M, Gilfillan S, Colonna M

LINGO4 coordinates ILC3-intrinsic IL-22 production and microbiota-mediated ILC3 homeostasis.
J Exp Med. 2026;223(6):ePub - PMID: 42048289 - PMCID: PMC13138468 - DOI: 10.1084/jem.20252632

Graham DB, Xavier RJ

Mechanisms of inflammatory bowel diseases: Insights from human genetics and chemical biology.
Immunity. 2026;59(5):1184-1200 - PMID: 42049036 - PMCID: PMC13132028 - DOI: 10.1016/j.immuni.2026.04.002

Steinberg R, Pust MM, Arias-Rojas A, Pishchany G, Ramsey KA, Kieninger E, Moeller A, Casaulta C, Hilty M, Latzin P, SCILD Study Group, BILD Study Group, Korten I, Xavier RJ

An infant nasal microbial gene atlas uncovers intervention-driven microbiome shifts and salt-resistant pathogen expansion.
Cell Host Microbe. 2026;34(5):925-941.e6 - PMID: 42013836 - DOI: 10.1016/j.chom.2026.03.019

Chen X, Holtzman DM, Colonna M.

Immunity in Alzheimer's disease: From mechanisms to therapies
mmunity. 2026;59(3):524-541 - PMID: 41759511 - DOI: 10.1016/j.immuni.2026.02.004

Chen Y, Liu Y, Nguyen K, Wu J, Song S, Lin K, Rodrigues PF, Du S, Zhou C, Xiong K, Bosch M, Lin PB, Khantakova D, Wu S, Wu M, Yuede C, Holtzman DM, Colonna M

Targeting amyloid-β pathology by chimeric antigen receptor astrocyte (CAR-A) therapy.
Science. 2026;391(6789):eads3972 - PMID: 41785364 - PMCID: PMC13294515 - DOI: 10.1126/science.ads3972

Tanoue T, Nagayama M, Roochana AJA, Zimmerman S, Ashenberg O, Jain T, Igarashi R, Sasajima S, Takeshita K, Hetherington N, Okahashi N, Ueda M, Konishi M, Nakayama Y, Minoda A, Skelly AN, Minokoshi Y, Pucci N, Mende DR, Arita M, Yamamoto H, Watanabe S, Miura K, Behie SW, Suda W, Sato T, Atarashi K, Matsushita M, Kajimura S, Plichta DR, Saito M, Xavier RJ, Honda K

Microbiota-mediated induction of beige adipocytes in response to dietary cues.
Nature. 2026;653(8114):499-509 - PMID: 41781619 - PMCID: PMC13051337 - DOI: 10.1038/s41586-026-10205-3

Fachi JL, de Oliveira S, Trsan T, Molgora M, Fernandes Rodrigues P, Gilfillan S, Ulezko Antonova A, Chang HW, Penati S, Cao S, Cella M, Colonna M

Divergent ILC3 responses to PDGF-D control mucosal immunity.
Sci Immunol. 2026;11(116):eaea6848 - PMID: 41758927 - DOI: 10.1126/sciimmunol.aea6848

Reeve MP, Kanai M, Graham DB, Karjalainen J, Luo S, Kolosov N, Adams C, Ritari J, Karczewski KJ, Kiiskinen T, Jiang Y, Fuller Z, Mehtonen J, Kurki MI, Khan Z, FinnGen, Partanen J, McCarthy MI, Artomov M, Palotie A, Tuomi T, Pirinen M, Kero J, Xavier RJ, Daly MJ, Ripatti S

Genome-wide association analyses of autoimmune hypothyroidism reveal autoimmune and thyroid-specific contributions and an inverse relationship with cancer risk.
Nat Genet. 2026;58(3):550-559 - PMID: 41748903 - PMCID: PMC12987720 - DOI: 10.1038/s41588-026-02521-1

Fiskin E, Eraslan G, Alora-Palli MB, Jain T, Leyva-Castillo JM, Kim S, Choe H, Lareau CA, Lau H, Finan EP, Teixeira-Soldano I, LaBere B, Chu A, Woods B, Chou J, Slyper M, Waldman J, Islam S, Schneider L, Phipatanakul W, Platt C, Rozenblatt-Rosen O, Delorey TM, Ashenberg O, Deguine J, Smith GP, Geha RS, Regev A, Xavier RJ

Multi-modal skin atlas identifies a multicellular immune-stromal community associated with disrupted cornification and specific T cell expansion in atopic dermatitis.
Nat Commun. 2026;17(1):ePub - PMID: 41741455 - PMCID: PMC13057205 - DOI: 10.1038/s41467-026-69587-7

Thurimella K, Wu E, Li C, Graham DB, Owens RM, Plichta DR, Sokol CL, Xavier RJ, Bacallado S

Identifying microbial protease allergens through protein language model-guided homology.
Cell Syst. 2026;17(3):101510 - PMID: 41722567 - PMCID: PMC13015258 - DOI: 10.1016/j.cels.2025.101510

Rodrigues PF, Wu S, Trsan T, Bhattarai B, Panda SK, Fachi JL, Cella M, Colonna M

RORγt+ dendritic cells are a distinct lymphoid-derived lineage.
Sci Immunol. 2026;11(116):eaed7439 - PMID: 41591258 - PMCID: PMC13236574 - DOI: 10.1126/sciimmunol.aed7439

Sullivan JR, Ferrara KM, Barrick R, Romano KP, Warrier T, Hung DT

An inducible CRISPRi system for phenotypic analysis of essential genes in Pseudomonas aeruginosa.
MBio. 2026;17(3):e0276725 - PMID: 41670347 - PMCID: PMC12977507 - DOI: 10.1128/mbio.02767-25

Penaranda C, Brenner EP, Clatworthy AE, Cosimi LA, Ravi J, Hung DT

Genomic comparison and phenotypic characterization of Pseudomonas aeruginosa isolates across environmental and diverse clinical isolation sites.
mSystems. 2026;11(3):e0136225 - PMID: 41641989 - PMCID: PMC13011455 - DOI: 10.1128/msystems.01362-25

Jaiswal A, Kooistra T, Pokatayev V, Bastos HN, Santos RF, Sarraf TR, Segerstolpe Å, Lin C, Amir-Zilberstein L, Twardus S, Shannon K, Murphy SP, Knipe R, Ganzleben IK, Black KE, Delorey TM, Graham DB, Hung YP, Hariri LP, Deguine J, Carvalho A, Medoff BD, Xavier RJ

Spatial transcriptomics reveals altered communities and drivers of aberrant epithelia and pro-fibrotic fibroblasts in interstitial lung diseases.
Cell Genom. 2026;6(3):101066 - PMID: 41576947 - PMCID: PMC12985369 - DOI: 10.1016/j.xgen.2025.101066

Rush JS, Wertheimer JD, Goldberg SD, Raymond D, Szuchnicki M, Baltus AJ, Branson J, Stratton CF, Patrick AN, Steele R, Adhikary S, Del Rosario A, Liu A, Gomersall NJ, Chung M, Ranaghan MJ, Gu X, Brandt M, Cao Z, Bebenek A, Oliver BA, Hoebe K, Szewczuk LM, Venable JD, Graham DB, Towne J, Xavier RJ

Human genetics guides the discovery of CARD9 inhibitors with anti-inflammatory activity.
Cell. 2026;189(5):1356-1370.e26 - PMID: 41547356 - PMCID: PMC12817910 - DOI: 10.1016/j.cell.2025.12.013

Ashenberg O, Xavier RJ

Bridging AI and biology: Foundation models meet human physiology and disease.
Med. 2026;7(1):100971 - PMID: 41519120 - DOI: 10.1016/j.medj.2025.100971

Pokatayev V, Jaiswal A, Shih AR, Segerstolpe Å, Li B, Creasey EA, Zhao Y, Lin C, Murphy S, Chou CH, Graham DB, Xavier RJ

Bidirectional CRISPR screens decode a GLIS3-dependent fibrotic cell circuit.
Nature. 2026;650(8103):997-1006 - PMID: 41501466 - PMCID: PMC12820784 - DOI: 10.1038/s41586-025-09907-x

Thurimella K, Mohamed AMT, Li C, Vatanen T, Graham DB, Owens RM, La Rosa SL, Plichta DR, Bacallado S, Xavier RJ

Protein language models uncover carbohydrate-active enzyme function in metagenomics.
BMC Bioinformatics. 2025;26(1):285 - PMID: 41299229 - PMCID: PMC12659350 - DOI: 10.1186/s12859-025-06286-y

Ambros VR, Chalfie M, Daul AL, Fire AZ, Hall DH, Horvitz HR, Mello CC, Ruvkun G, Schroeder NE, Sternberg PW, Rougvie AE

From nematode to Nobel: How community-shared resources fueled the rise of Caenorhabditis elegans as a research organism.
Proc Natl Acad Sci U S A. 2025;122(48):e2522808122 - PMID: 41284858 - PMCID: PMC12685049 - DOI: 10.1073/pnas.2522808122

Bond AN, Orzechowski M, Zhang S, Ben-Zion I, Lemmer A, Garry N, Lee K, Chen M, Delano K, Gath E, Golas AL, Nietupski R, Fitzgerald M, Ehrt S, Rubin EJ, Sassetti CM, Schnappinger D, Shoresh N, Hunt DK, Gomez JE, Hung DT

Reference-based chemical-genetic interaction profiling to elucidate small molecule mechanism of action in Mycobacterium tuberculosis.
Nat Commun. 2025;16(1):9673 - PMID: 41184262 - PMCID: PMC12583738 - DOI: 10.1038/s41467-025-64662-x
Total: 2523