Publications

Enhanced proofreading governs CRISPR-Cas9 targeting accuracy.

Chen JS, Dagdas YS, Kleinstiver BP, Welch MM, Sousa AA, Harrington LB, Sternberg SH, Joung JK, Yildiz A, Doudna JA
Nature. 2017;:ePub - PMID: 28931002

An Anti-Persister Strategy for the Treatment of Chronic Pseudomonas aeruginosa Infections.

Koeva M, Gutu AD, Hebert W, Wager JD, Yonker LM, O'Toole GA, Ausubel FM, Moskowitz SM, Joseph-McCarthy D
Antimicrob Agents Chemother. 2017;:ePub - PMID: 28923873

SHANK3 Regulates Intestinal Barrier Function Through Modulating ZO-1 Expression Through the PKCε-dependent Pathway.

Wei SC, Yang-Yen HF, Tsao PN, Weng MT, Tung CC, Yu LCH, Lai LC, Hsiao JH, Chuang EY, Shun CT, Ni YH, Xavier RJ, Podolsky DK, Yen JJY, Wong JM
Inflamm Bowel Dis. 2017;:ePub - PMID: 28922251

SHANK3 Regulates Intestinal Barrier Function Through Modulating ZO-1 Expression Through the PKCε-dependent Pathway.

Wei SC, Yang-Yen HF, Tsao PN, Weng MT, Tung CC, Yu LCH, Lai LC, Hsiao JH, Chuang EY, Shun CT, Ni YH, Xavier RJ, Podolsky DK, Yen JJY, Wong JM
Inflamm Bowel Dis. 2017;23(10):1730-1740 - PMID: 28906292

The Ubiquitin Ligase Smurf1 Functions in Selective Autophagy of Mycobacterium tuberculosis and Anti-tuberculous Host Defense.

Franco LH, Nair VR, Scharn CR, Xavier RJ, Torrealba JR, Shiloh MU, Levine B
Cell Host Microbe. 2017;22(3):421-423 - PMID: 28910640

Obesity, but not physical activity, is associated with higher prevalence of asymptomatic diverticulosis.

Mashayekhi R, Bellavance DR, Chin SM, Maxner B, Staller K, Xavier RJ, Chung DC, Khalili H
Clin Gastroenterol Hepatol. 2017;:ePub - PMID: 28899671

Autophagy-Independent Lysosomal Targeting Regulated by ULK1/2-FIP200 and ATG9.

Goodwin JM, Dowdle WE, DeJesus R, Wang Z, Bergman P, Kobylarz M, Lindeman A, Xavier RJ, McAllister G, Nyfeler B, Hoffman G, Murphy LO
Cell Rep. 2017;20(10):2341-2356 - PMID: 28877469

Investment in secreted enzymes during nutrient-limited growth is utility dependent.

Cezairliyan B, Ausubel FM
Proc Natl Acad Sci U S A. 2017;:ePub - PMID: 28847943

Human genetic variation and the gut microbiome in disease.

Hall AB, Tolonen AC, Xavier RJ
Nat Rev Genet. 2017;:ePub - PMID: 28824167

Erratum: E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP.

Bist P, Cheong WS, Ng A, Dikshit N, Kim BH, Pulloor NK, Khameneh HJ, Hedl M, Shenoy AR, Balamuralidhar V, Malik NBA, Hong M, Neutzner A, Chin KC, Kobayashi KS, Bertoletti A, Mortellaro A, Abraham C, MacMicking JD, Xavier RJ, Sukumaran B
Nat Commun. 2017;8:16141 - PMID: 28820178

Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells.

Johannessen L, Sundberg TB, O'Connell DJ, Kolde R, Berstler J, Billings KJ, Khor B, Seashore-Ludlow B, Fassl A, Russell CN, Latorre IJ, Jiang B, Graham DB, Perez JR, Sicinski P, Phillips AJ, Schreiber SL, Gray NS, Shamji AF, Xavier RJ
Nat Chem Biol. 2017;:ePub - PMID: 28805801

Maintenance of macrophage transcriptional programs and intestinal homeostasis by epigenetic reader SP140.

Mehta S, Cronkite DA, Basavappa M, Saunders TL, Adiliaghdam F, Amatullah H, Morrison SA, Pagan JD, Anthony RM, Tonnerre P, Lauer GM, Lee JC, Digumarthi S, Pantano L, Ho Sui SJ, Ji F, Sadreyev R, Zhou C, Mullen AC, Kumar V, Li Y, Wijmenga C, Xavier RJ, Means TK, Jeffrey KL
Sci Immunol. 2017;2(9):ePub - PMID: 28783698

NIH Centers for Accelerated Innovations Program: principles, practices, successes and challenges.

Antman EM, Di Corleto PE, Freeman MW, Ganz T, Golan DE, Kitterman R, Loscalzo J, Low M, McKenna E, O'Connor AC, Palazzolo M, Parrish J, Reizes O, Ross RS, Vaughan C, Vince DG, Watts L, NIH Centers for Accelerated Innovations
Nat Rev Drug Discov. 2017;:ePub - PMID: 28775338

Metagenomic Sequencing of an Echovirus 30 Genome From Cerebrospinal Fluid of a Patient With Aseptic Meningitis and Orchitis.

Piantadosi A, Mukerji SS, Chitneni P, Cho TA, Cosimi LA, Hung DT, Goldberg MB, Sabeti PC, Kuritzkes DR, Grad YH
Open Forum Infect Dis. 2017;4(3):ofx138 - PMID: 28761901 - PMCID: PMC5534216

Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine.

Bel S, Pendse M, Wang Y, Li Y, Ruhn KA, Hassell B, Leal T, Winter SE, Xavier RJ, Hooper LV
Science. 2017;:ePub - PMID: 28751470

Burn-induced muscle metabolic derangements and mitochondrial dysfunction are associated with activation of HIF-1α and mTORC1: Role of protein farnesylation.

Nakazawa H, Ikeda K, Shinozaki S, Kobayashi M, Ikegami Y, Fu M, Nakamura T, Yasuhara S, Yu YM, Martyn JAJ, Tompkins RG, Shimokado K, Yorozu T, Ito H, Inoue S, Kaneki M
Sci Rep. 2017;7(1):6618 - PMID: 28747716

Nucleic Acid Extraction from Synthetic Mars Analog Soils for in situ Life Detection.

Mojarro A, Ruvkun G, Zuber MT, Carr CE
Astrobiology. 2017;:ePub - PMID: 28704064

Indoleacrylic Acid Produced by Commensal Peptostreptococcus Species Suppresses Inflammation.

Wlodarska M, Luo C, Kolde R, d'Hennezel E, Annand JW, Heim CE, Krastel P, Schmitt EK, Omar AS, Creasey EA, Garner AL, Mohammadi S, O'Connell DJ, Abubucker S, Arthur TD, Franzosa EA, Huttenhower C, Murphy LO, Haiser HJ, Vlamakis H, Porter JA, Xavier RJ
Cell Host Microbe. 2017;22(1):25-37.e6 - PMID: 28704649

Intestinal virome changes precede autoimmunity in type I diabetes-susceptible children.

Zhao G, Vatanen T, Droit L, Park A, Kostic AD, Poon TW, Vlamakis H, Siljander H, Härkönen T, Hämäläinen AM, Peet A, Tillmann V, Ilonen J, Wang D, Knip M, Xavier RJ, Virgin HW
Proc Natl Acad Sci U S A. 2017;:ePub - PMID: 28696303

Insight into the mechanism of nonenzymatic RNA primer extension from the structure of an RNA-GpppG complex.

Zhang W, Tam CP, Walton T, Fahrenbach AC, Birrane G, Szostak JW
Proc Natl Acad Sci U S A. 2017;:ePub - PMID: 28673998

A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase.

Wellington S, Nag PP, Michalska K, Johnston SE, Jedrzejczak RP, Kaushik VK, Clatworthy AE, Siddiqi N, McCarren P, Bajrami B, Maltseva NI, Combs S, Fisher SL, Joachimiak A, Schreiber SL, Hung DT
Nat Chem Biol. 2017;:ePub - PMID: 28671682

E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP.

Bist P, Cheong WS, Ng A, Dikshit N, Kim BH, Pulloor NK, Khameneh HJ, Hedl M, Shenoy AR, Balamuralidhar V, Malik NBA, Hong M, Neutzner A, Chin KC, Kobayashi KS, Bertoletti A, Mortellaro A, Abraham C, MacMicking JD, Xavier RJ, Sukumaran B
Nat Commun. 2017;8:15865 - PMID: 28656966

Fine-mapping inflammatory bowel disease loci to single-variant resolution.

Huang H, Fang M, Jostins L, Umićević Mirkov M, Boucher G, Anderson CA, Andersen V, Cleynen I, Cortes A, Crins F, D'Amato M, Deffontaine V, Dmitrieva J, Docampo E, Elansary M, Farh KK, Franke A, Gori AS, Goyette P, Halfvarson J, Haritunians T, Knight J, Lawrance IC, Lees CW, Louis E, Mariman R, Meuwissen T, Mni M, Momozawa Y, Parkes M, Spain SL, Théâtre E, Trynka G, Satsangi J, van Sommeren S, Vermeire S, Xavier RJ, International Inflammatory Bowel Disease Genetics Consortium, Weersma RK, Due ...
Nature. 2017;:ePub - PMID: 28658209

Characterization of a Francisella tularensis-Caenorhabditis elegans pathosystem for the evaluation of therapeutic compounds.

Jayamani E, Tharmalingam N, Rajamuthiah R, Coleman JJ, Kim W, Okoli I, Hernandez AM, Lee K, Nau GJ, Ausubel FM, Mylonakis E
Antimicrob Agents Chemother. 2017;:ePub - PMID: 28652232

Common and Potentially Prebiotic Origin for Precursors of Nucleotide Synthesis and Activation.

Fahrenbach AC, Giurgiu C, Tam CP, Li L, Hongo Y, Aono M, Szostak JW
J Am Chem Soc. 2017;:ePub - PMID: 28640999

Dissecting the human microbiome with single-cell genomics.

Tolonen AC, Xavier RJ
Genome Med. 2017;9(1):56 - PMID: 28615076

Discovery of nitrate-CPK-NLP signalling in central nutrient-growth networks.

Liu KH, Niu Y, Konishi M, Wu Y, Du H, Sun Chung H, Li L, Boudsocq M, McCormack M, Maekawa S, Ishida T, Zhang C, Shokat K, Yanagisawa S, Sheen J
Nature. 2017;545(7654):311-316

Genome editing of factor X in zebrafish reveals unexpected tolerance of severe defects in the common pathway.

Hu Z, Liu Y, Huarng MC, Menegatti M, Reyon D, Rost MS, Norris ZG, Richter CE, Stapleton AN, Chi NC, Peyvandi F, Joung JK, Shavit JA
Blood. 2017;:ePub - PMID: 28576875

Selective Induction of Homeostatic Th17 Cells in the Murine Intestine by Cholera Toxin Interacting with the Microbiota.

Zhao Q, Harbour SN, Kolde R, Latorre IJ, Tun HM, Schoeb TR, Turner H, Moon JJ, Khafipour E, Xavier RJ, Weaver CT, Elson CO
J Immunol. 2017;:ePub - PMID: 28539431

Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides.

Stairs S, Nikmal A, Bucar DK, Zheng SL, Szostak JW, Powner MW
Nat Commun. 2017;8:15270 - PMID: 28524845 - PMCID: PMC5454461

Adult-onset, chronic, cyclic thrombocytopenia in a Rhesus macaque (Macaca mulatta) after dengue virus vaccination and viral challenge.

Frydman GH, Metcalf Pate KA, Marini RP, de Laforcade AM, Bosch I, Bakthavatchalu V, Muthupalani S, Swennes AG, Lyons CE, Tompkins RG, Fox JG
Vet Clin Pathol. 2017;:ePub - PMID: 28518476

The Narrow Road to the Deep Past.

Szostak JW
Angew Chem Int Ed Engl. 2017;:ePub - PMID: 28514493

Epitope-specific immunotherapy targeting CD4-positive T cells in coeliac disease: two randomised, double-blind, placebo-controlled phase 1 studies.

Goel G, King T, Daveson AJ, Andrews JM, Krishnarajah J, Krause R, Brown GJE, Fogel R, Barish CF, Epstein R, Kinney TP, Miner PB, Tye-Din JA, Girardin A, Taavela J, Popp A, Sidney J, Mäki M, Goldstein KE, Griffin PH, Wang S, Dzuris JL, Williams LJ, Sette A, Xavier RJ, Sollid LM, Jabri B, Anderson RP
Lancet Gastroenterol Hepatol. 2017;:ePub - PMID: 28506538

Systematic, multiparametric analysis of Mycobacterium tuberculosis intracellular infection offers insight into coordinated virulence.

Barczak AK, Avraham R, Singh S, Luo SS, Zhang WR, Bray MA, Hinman AE, Thompson M, Nietupski RM, Golas A, Montgomery P, Fitzgerald M, Smith RS, White DW, Tischler AD, Carpenter AE, Hung DT
PLoS Pathog. 2017;13(5):e1006363 - PMID: 28505176 - PMCID: PMC5444860

Gut Microbiome Function Predicts Response to Anti-integrin Biologic Therapy in Inflammatory Bowel Diseases.

Ananthakrishnan AN, Luo C, Yajnik V, Khalili H, Garber JJ, Stevens BW, Cleland T, Xavier RJ
Cell Host Microbe. 2017;21(5):603-610.e3 - PMID: 28494241

CIRCLE-seq: a highly sensitive in vitro screen for genome-wide CRISPR-Cas9 nuclease off-targets.

Tsai SQ, Nguyen NT, Malagon-Lopez J, Topkar VV, Aryee MJ, Joung JK
Nat Methods. 2017;14(6):607-614 - PMID: 28459458

Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway.

Ando K, Shah AK, Sachdev V, Kleinstiver BP, Taylor-Parker J, Welch MM, Hu Y, Salgia R, White FM, Parvin JD, Ozonoff A, Rameh LE, Joung JK, Bharti AK
Oncotarget. 2017;:ePub - PMID: 28415827

Nucleic acid detection with CRISPR-Cas13a/C2c2.

Gootenberg JS, Abudayyeh OO, Lee JW, Essletzbichler P, Dy AJ, Joung J, Verdine V, Donghia N, Daringer NM, Freije CA, Myhrvold C, Bhattacharyya RP, Livny J, Regev A, Koonin EV, Hung DT, Sabeti PC, Collins JJ, Zhang F
Science. 2017;356(6336):438-442 - PMID: 28408723

Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease.

Bouziat R, Hinterleitner R, Brown JJ, Stencel-Baerenwald JE, Ikizler M, Mayassi T, Meisel M, Kim SM, Discepolo V, Pruijssers AJ, Ernest JD, Iskarpatyoti JA, Costes LM, Lawrence I, Palanski BA, Varma M, Zurenski MA, Khomandiak S, McAllister N, Aravamudhan P, Boehme KW, Hu F, Samsom JN, Reinecker HC, Kupfer SS, Guandalini S, Semrad CE, Abadie V, Khosla C, Barreiro LB, Xavier RJ, Ng A, Dermody TS, Jabri B
Science. 2017;356(6333):44-50 - PMID: 28386004

Local and Systemic Changes Associated with Long-term, Percutaneous, Static Implantation of Titanium Alloys in Rhesus Macaques (Macaca mulatta).

Frydman GH, Marini RP, Bakthavatchalu V, Biddle KE, Muthupalani S, Vanderburg CR, Lai B, Bendapudi PK, Tompkins RG, Fox JG
Comp Med. 2017;67(2):165-175 - PMID: 28381317 - PMCID: PMC5402736

A Microbiome Foundation for the Study of Crohn's Disease.

Gevers D, Kugathasan S, Knights D, Kostic AD, Knight R, Xavier RJ
Cell Host Microbe. 2017;21(3):301-304 - PMID: 28279336

An Alpha7 Nicotinic Acetylcholine Receptor Agonist (GTS-21) Promotes C2C12 Myonuclear Accretion in Association with Release of Interleukin-6 (IL-6) and Improves Survival in Burned Mice.

Khan MA, Khan MF, Kashiwagi S, Kem WR, Yasuhara S, Kaneki M, Tompkins RG, Martyn JA
Shock. 2017;:ePub - PMID: 28282360

US immigration order strikes against biotech.

Levin JM, Holtzman SH, Maraganore J, Hastings PJ, Cohen R, Dahiyat B, Adams J, Adams C, Ahrens B, Albers J, Aspinall MG, Audia JE, Babler M, Barrett P, Barry Z, Bermingham N, Bloch S, Blum RI, Bolno PB, Bonney MW, Booth B, Bradbury DM, Brauer SK, Byers B, Cagnoni PJ, Cali BM, Ciechanover I, Clark C, Clayman MD, Cleland JL, Cobb P, Cooper R, Currie MG, Diekman J, Dobmeier EL, Doerfler D, Donley EL, Dunsire D, During M, Eckstein JW, Elenko E, Exter NA, Fleming JJ, Flesher GJ, Formela JF, Forre ...
Nat Biotechnol. 2017;35(3):204-206 - PMID: 28267733

Prediction of complicated disease course for children newly diagnosed with Crohn's disease: a multicentre inception cohort study.

Kugathasan S, Denson LA, Walters TD, Kim MO, Marigorta UM, Schirmer M, Mondal K, Liu C, Griffiths A, Noe JD, Crandall WV, Snapper S, Rabizadeh S, Rosh JR, Shapiro JM, Guthery S, Mack DR, Kellermayer R, Kappelman MD, Steiner S, Moulton DE, Keljo D, Cohen S, Oliva-Hemker M, Heyman MB, Otley AR, Baker SS, Evans JS, Kirschner BS, Patel AS, Ziring D, Trapnell BC, Sylvester FA, Stephens MC, Baldassano RN, Markowitz JF, Cho J, Xavier RJ, Huttenhower C, Aronow BJ, Gibson G, Hyams JS, Dubinsky MC
Lancet. 2017;389(10080):1710-1718 - PMID: 28259484

Corrigendum: SIKs control osteocyte responses to parathyroid hormone.

Wein MN, Liang Y, Goransson O, Sundberg TB, Wang J, Williams EA, O'Meara MJ, Govea N, Beqo B, Nishimori S, Nagano K, Brooks DJ, Martins JS, Corbin B, Anselmo A, Sadreyev R, Wu JY, Sakamoto K, Foretz M, Xavier RJ, Baron R, Bouxsein ML, Gardella TJ, Divieti-Pajevic P, Gray NS, Kronenberg HM
Nat Commun. 2017;8:14745 - PMID: 28224982 - PMCID: PMC5322529

MAPK Assays in Arabidopsis MAMP-PRR Signal Transduction.

Chung HS, Sheen J
Methods Mol Biol. 2017;1578:155-166 - PMID: 28220422

Ribosomal mutations promote the evolution of antibiotic resistance in a multidrug environment.

Gomez JE, Kaufmann-Malaga BB, Wivagg CN, Kim PB, Silvis MR, Renedo N, Ioerger TR, Ahmad R, Livny J, Fishbein S, Sacchettini JC, Carr SA, Hung DT
Elife. 2017;6:ePub - PMID: 28220755 - PMCID: PMC5319836

Enhanced Nonenzymatic RNA Copying with 2-Aminoimidazole Activated Nucleotides.

Li L, Prywes N, Tam CP, O'Flaherty DK, Lelyveld VS, Izgu EC, Pal A, Szostak JW
J Am Chem Soc. 2017;139(5):1810-1813 - PMID: 28117989

The NBS-LRR architectures of plant R-proteins and metazoan NLRs evolved in independent events.

Urbach JM, Ausubel FM
Proc Natl Acad Sci U S A. 2017;114(5):1063-1068 - PMID: 28096345 - PMCID: PMC5293065

Multi-institute analysis of carbapenem resistance reveals remarkable diversity, unexplained mechanisms, and limited clonal outbreaks.

Cerqueira GC, Earl AM, Ernst CM, Grad YH, Dekker JP, Feldgarden M, Chapman SB, Reis-Cunha JL, Shea TP, Young S, Zeng Q, Delaney ML, Kim D, Peterson EM, O'Brien TF, Ferraro MJ, Hooper DC, Huang SS, Kirby JE, Onderdonk AB, Birren BW, Hung DT, Cosimi LA, Wortman JR, Murphy CI, Hanage WP
Proc Natl Acad Sci U S A. 2017;114(5):1135-1140 - PMID: 28096418 - PMCID: PMC5293017

iNOS as a Driver of Inflammation and Apoptosis in Mouse Skeletal Muscle after Burn Injury: Possible Involvement of Sirt1 S-Nitrosylation-Mediated Acetylation of p65 NF-?B and p53.

Nakazawa H, Chang K, Shinozaki S, Yasukawa T, Ishimaru K, Yasuhara S, Yu YM, Martyn JA, Tompkins RG, Shimokado K, Kaneki M
PLoS One. 2017;12(1):e0170391 - PMID: 28099528 - PMCID: PMC5242494

Downstream Oligonucleotides Strongly Enhance the Affinity of GMP to RNA Primer-Template Complexes.

Tam CP, Fahrenbach AC, Björkbom A, Prywes N, Izgu EC, Szostak JW
J Am Chem Soc. 2017;139(2):571-574 - PMID: 28055190

ATP Binding Cassette Transporter ABCA7 Regulates NKT Cell Development and Function by Controlling CD1d Expression and Lipid Raft Content.

Nowyhed HN, Chandra S, Kiosses W, Marcovecchio P, Andary F, Zhao M, Fitzgerald ML, Kronenberg M, Hedrick CC
Sci Rep. 2017;7:40273 - PMID: 28091533 - PMCID: PMC5238393

DNA-binding Specificity Is a Major Determinant of the Activity and Toxicity of Zinc-finger Nucleases.

Cornu TI, Thibodeau-Beganny S, Guhl E, Alwin S, Eichtinger M, Joung JK, Cathomen T
Mol Ther. 2016;16(2):352-358 - PMID: 28178540

Metagenomic Characterization of Microbial Communities In Situ Within the Deeper Layers of the Ileum in Crohn's Disease.

Pedamallu CS, Bhatt AS, Bullman S, Fowler S, Freeman SS, Durand J, Jung J, Duke F, Manzo V, Cai D, Ananthakrishnan A, Ojesina AI, Ramachandran A, Gevers D, Xavier RJ, Bhan AK, Meyerson M, Yajnik V
Cell Mol Gastroenterol Hepatol. 2016;2(5):563-566.e5 - PMID: 28174737 - PMCID: PMC5042890

Genome Editing Technologies: Defining a Path to Clinic: Genomic Editing: Establishing Preclinical Toxicology Standards, Bethesda, Maryland 10 June 2014.

Corrigan-Curay J, O'Reilly M, Kohn DB, Cannon PM, Bao G, Bushman FD, Carroll D, Cathomen T, Joung JK, Roth D, Sadelain M, Scharenberg AM, von Kalle C, Zhang F, Jambou R, Rosenthal E, Hassani M, Singh A, Porteus MH
Mol Ther. 2016;23(5):796-806 - PMID: 28142000

Influence of maternal breast milk ingestion on acquisition of the intestinal microbiome in preterm infants.

Gregory KE, Samuel BS, Houghteling P, Shan G, Ausubel FM, Sadreyev RI, Walker WA
Microbiome. 2016;4(1):68 - PMID: 28034306 - PMCID: PMC5200970

Unusual Base-Pairing Interactions in Monomer-Template Complexes.

Zhang W, Tam CP, Wang J, Szostak JW
ACS Cent Sci. 2016;2(12):916-926 - PMID: 28058281 - PMCID: PMC5200924

The Ubiquitin Ligase Smurf1 Functions in Selective Autophagy of Mycobacterium tuberculosis and Anti-tuberculous Host Defense.

Franco LH, Nair VR, Scharn CR, Xavier RJ, Torrealba JR, Shiloh MU, Levine B
Cell Host Microbe. 2016;21(1):59-72 - PMID: 28017659

Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity.

Schirmer M, Smeekens SP, Vlamakis H, Jaeger M, Oosting M, Franzosa EA, Horst RT, Jansen T, Jacobs L, Bonder MJ, Kurilshikov A, Fu J, Joosten LA, Zhernakova A, Huttenhower C, Wijmenga C, Netea MG, Xavier RJ
Cell. 2016;167(7):1897 - PMID: 27984736

TMEM258 Is a Component of the Oligosaccharyltransferase Complex Controlling ER Stress and Intestinal Inflammation.

Graham DB, Lefkovith A, Deelen P, de Klein N, Varma M, Boroughs A, Desch AN, Ng AC, Guzman G, Schenone M, Petersen CP, Bhan AK, Rivas MA, Daly MJ, Carr SA, Wijmenga C, Xavier RJ
Cell Rep. 2016;17(11):2955-2965 - PMID: 27974209

N-Carboxyanhydride-Mediated Fatty Acylation of Amino Acids and Peptides for Functionalization of Protocell Membranes.

Izgu EC, Björkbom A, Kamat NP, Lelyveld VS, Zhang W, Jia TZ, Szostak JW
J Am Chem Soc. 2016;138(51):16669-16676 - PMID: 27959544

Tribbles ortholog NIPI-3 and bZIP transcription factor CEBP-1 regulate a Caenorhabditis elegans intestinal immune surveillance pathway.

McEwan DL, Feinbaum RL, Stroustrup N, Haas W, Conery AL, Anselmo A, Sadreyev R, Ausubel FM
BMC Biol. 2016;14(1):105 - PMID: 27927200 - PMCID: PMC5143455

The Csk-Associated Adaptor PAG Inhibits Effector T Cell Activation in Cooperation with Phosphatase PTPN22 and Dok Adaptors.

Davidson D, Zhong MC, Pandolfi PP, Bolland S, Xavier RJ, Seed B, Li X, Gu H, Veillette A
Cell Rep. 2016;17(10):2776-2788 - PMID: 27926878

Visceral Adiposity, Genetic Susceptibility, and Risk of Complications Among Individuals with Crohn's Disease.

Van Der Sloot KW, Joshi AD, Bellavance DR, Gilpin KK, Stewart KO, Lochhead P, Garber JJ, Giallourakis C, Yajnik V, Ananthakrishnan AN, Alizadeh BZ, Xavier RJ, Khalili H
Inflamm Bowel Dis. 2016;23(1):82-88 - PMID: 27893544 - PMCID: PMC5177457

The Role of the Histone Methyltransferase Enhancer of Zeste Homolog 2 (EZH2) in the Pathobiological Mechanisms Underlying Inflammatory Bowel Disease (IBD).

Sarmento OF, Svingen PA, Xiong Y, Sun Z, Bamidele AO, Mathison AJ, Smyrk TC, Nair AA, Gonzalez MM, Sagstetter MR, Baheti S, McGovern DP, Friton JJ, Papadakis KA, Gautam G, Xavier RJ, Urrutia RA, Faubion WA
J Biol Chem. 2016;292(2):706-722 - PMID: 27909059 - PMCID: PMC5241744

RNF166 Determines Recruitment of Adaptor Proteins during Antibacterial Autophagy.

Heath RJ, Goel G, Baxt LA, Rush JS, Mohanan V, Paulus GL, Jani V, Lassen KG, Xavier RJ
Cell Rep. 2016;17(9):2183-2194 - PMID: 27880896 - PMCID: PMC5192565

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity.

Arts RJ, Novakovic B, Ter Horst R, Carvalho A, Bekkering S, Lachmandas E, Rodrigues F, Silvestre R, Cheng SC, Wang SY, Habibi E, Gonçalves LG, Mesquita I, Cunha C, van Laarhoven A, van de Veerdonk FL, Williams DL, van der Meer JW, Logie C, O'Neill LA, Dinarello CA, Riksen NP, van Crevel R, Clish C, Notebaart RA, Joosten LA, Stunnenberg HG, Xavier RJ, Netea MG
Cell Metab. 2016;24(6):807-819 - PMID: 27866838

Erratum to: Vedolizumab Therapy Is Associated with an Improvement in Sleep Quality and Mood in Inflammatory Bowel Diseases.

Stevens BW, Borren NZ, Velonias G, Conway G, Cleland T, Andrews E, Khalili H, Garber JJ, Xavier RJ, Yajnik V, Ananthakrishnan AN
Dig Dis Sci. 2016;62(2):552 - PMID: 27864657

SIKs control osteocyte responses to parathyroid hormone.

Wein MN, Liang Y, Goransson O, Sundberg TB, Wang J, Williams EA, O'Meara MJ, Govea N, Beqo B, Nishimori S, Nagano K, Brooks DJ, Martins JS, Corbin B, Anselmo A, Sadreyev R, Wu JY, Sakamoto K, Foretz M, Xavier RJ, Baron R, Bouxsein ML, Gardella TJ, Divieti-Pajevic P, Gray NS, Kronenberg HM
Nat Commun. 2016;7:13176 - PMID: 27759007 - PMCID: PMC5075806

TNF-?/IL-10 Ratio Correlates with Burn Severity and May Serve as a Risk Predictor of Increased Susceptibility to Infections.

Tsurumi A, Que YA, Ryan CM, Tompkins RG, Rahme LG
Front Public Health. 2016;4:216 - PMID: 27761434 - PMCID: PMC5050217

KERIS: kaleidoscope of gene responses to inflammation between species.

Li P, Tompkins RG, Xiao W,
Nucleic Acids Res. 2016;45(D1):D908-D914 - PMID: 27789704 - PMCID: PMC5210651

Vedolizumab Therapy Is Associated with an Improvement in Sleep Quality and Mood in Inflammatory Bowel Diseases.

Stevens BW, Borren NZ, Velonias G, Conway G, Cleland T, Andrews E, Khalili H, Garber JG, Xavier RJ, Yajnik V, Ananthakrishnan AN
Dig Dis Sci. 2016;62(1):197-206 - PMID: 27796768 - PMCID: PMC5218976

Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease.

Imhann F, Vich Vila A, Bonder MJ, Fu J, Gevers D, Visschedijk MC, Spekhorst LM, Alberts R, Franke L, van Dullemen HM, Ter Steege RW, Huttenhower C, Dijkstra G, Xavier RJ, Festen EA, Wijmenga C, Zhernakova A, Weersma RK
Gut. 2016;:ePub - PMID: 27802154

A Functional Genomics Approach to Understand Variation in Cytokine Production in Humans.

Li Y, Oosting M, Smeekens SP, Jaeger M, Aguirre-Gamboa R, Le KT, Deelen P, Ricaño-Ponce I, Schoffelen T, Jansen AF, Swertz MA, Withoff S, van de Vosse E, van Deuren M, van de Veerdonk F, Zhernakova A, van der Meer JW, Xavier RJ, Franke L, Joosten LA, Wijmenga C, Kumar V, Netea MG
Cell. 2016;167(4):1099-1110.e14 - PMID: 27814507

Host and Environmental Factors Influencing Individual Human Cytokine Responses.

Ter Horst R, Jaeger M, Smeekens SP, Oosting M, Swertz MA, Li Y, Kumar V, Diavatopoulos DA, Jansen AF, Lemmers H, Toenhake-Dijkstra H, van Herwaarden AE, Janssen M, van der Molen RG, Joosten I, Sweep FC, Smit JW, Netea-Maier RT, Koenders MM, Xavier RJ, van der Meer JW, Dinarello CA, Pavelka N, Wijmenga C, Notebaart RA, Joosten LA, Netea MG
Cell. 2016;167(4):1111-1124.e13 - PMID: 27814508

Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity.

Schirmer M, Smeekens SP, Vlamakis H, Jaeger M, Oosting M, Franzosa EA, Jansen T, Jacobs L, Bonder MJ, Kurilshikov A, Fu J, Joosten LA, Zhernakova A, Huttenhower C, Wijmenga C, Netea MG, Xavier RJ
Cell. 2016;167(4):1125-1136.e8 - PMID: 27814509 - PMCID: PMC5131922

Differential Effects of Environmental and Genetic Factors on T and B Cell Immune Traits.

Aguirre-Gamboa R, Joosten I, Urbano PC, van der Molen RG, van Rijssen E, van Cranenbroek B, Oosting M, Smeekens S, Jaeger M, Zorro M, Withoff S, van Herwaarden AE, Sweep FC, Netea RT, Swertz MA, Franke L, Xavier RJ, Joosten LA, Netea MG, Wijmenga C, Kumar V, Li Y, Koenen HJ
Cell Rep. 2016;17(9):2474-2487 - PMID: 27818087 - PMCID: PMC5130901

Hold the Pendulum: Rates of Acute Kidney Injury are Increased in Patients Who Receive Resuscitation Volumes Less than Predicted by the Parkland Equation.

Mason SA, Nathens AB, Finnerty CC, Gamelli RL, Gibran NS, Arnoldo BD, Tompkins RG, Herndon DN, Jeschke MG,
Ann Surg. 2016;264(6):1142-1147 - PMID: 27828823 - PMCID: PMC5111808

Effect of terminal 3'-hydroxymethyl modification of an RNA primer on nonenzymatic primer extension.

Pal A, Das RS, Zhang W, Lang M, McLaughlin LW, Szostak JW
Chem Commun (Camb). 2016;52(80):11905-11907 - PMID: 27722518

The metabolic stress response to burn trauma: current understanding and therapies.

Porter C, Tompkins RG, Finnerty CC, Sidossis LS, Suman OE, Herndon DN
Lancet. 2016;388(10052):1417-1426 - PMID: 27707498

Corrigendum: Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi.

Li Y, Oosting M, Deelen P, Ricaño-Ponce I, Smeekens S, Jaeger M, Matzaraki V, Swertz MA, Xavier RJ, Franke L, Wijmenga C, Joosten LA, Kumar V, Netea MG
Nat Med. 2016;22(10):1192 - PMID: 27711068

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages.

Mills EL, Kelly B, Logan A, Costa AS, Varma M, Bryant CE, Tourlomousis P, Däbritz JH, Gottlieb E, Latorre I, Corr SC, McManus G, Ryan D, Jacobs HT, Szibor M, Xavier RJ, Braun T, Frezza C, Murphy MP, O'Neill LA
Cell. 2016;167(2):457-470.e13 - PMID: 27667687

Characterization of candidate genes in inflammatory bowel disease-associated risk loci.

Peloquin JM, Goel G, Kong L, Huang H, Haritunians T, Sartor RB, Daly MJ, Newberry RD, McGovern DP, Yajnik V, Lira SA, Xavier RJ
JCI Insight. 2016;1(13):e87899 - PMID: 27668286 - PMCID: PMC5033062

A perspective on single cell behavior during infection.

Avraham R, Hung DT
Gut Microbes. 2016;:0 - PMID: 27658058 - PMCID: PMC5153611

Oligoarginine peptides slow strand annealing and assist non-enzymatic RNA replication.

Jia TZ, Fahrenbach AC, Kamat NP, Adamala KP, Szostak JW
Nat Chem. 2016;8(10):915-21 - PMID: 27657866 - PMCID: PMC5061144

Changes in neutrophil migration patterns upon contact with platelets in a microfluidic assay.

Frydman GH, Le A, Ellett F, Jorgensen J, Fox JG, Tompkins RG, Irimia D
J Leukoc Biol. 2016;101(3):797-806 - PMID: 27630219 - PMCID: PMC5295852

Erratum: A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis.

Rivas MA, Graham D, Sulem P, Stevens C, Desch AN, Goyette P, Gudbjartsson D, Jonsdottir I, Thorsteinsdottir U, Degenhardt F, Mucha S, Kurki MI, Li D, D'Amato M, Annese V, Vermeire S, Weersma RK, Halfvarson J, Paavola-Sakki P, Lappalainen M, Lek M, Cummings B, Tukiainen T, Haritunians T, Halme L, Koskinen LL, Ananthakrishnan AN, Luo Y, Heap GA, Visschedijk MC, , , MacArthur DG, Neale BM, Ahmad T, Anderson CA, Brant SR, Duerr RH, Silverberg MS, Cho JH, Palotie A, Saavalainen P, Kontula K, Fä ...
Nat Commun. 2016;7:12869 - PMID: 27619887 - PMCID: PMC5027274

Genomic analysis of the evolution of fluoroquinolone resistance in Mycobacterium tuberculosis prior to tuberculosis diagnosis.

Zhang D, Gomez JE, Chien JY, Haseley N, Desjardins CA, Earl AM, Hsueh PR, Hung DT
Antimicrob Agents Chemother. 2016;60(11):6600-6608 - PMID: 27572408 - PMCID: PMC5075065

On the origin of life.

Szostak JW
Medicina (B Aires). 2016;76(4):199-203 - PMID: 27576276

A highly reactive imidazolium-bridged dinucleotide intermediate in nonenzymatic RNA primer extension.

Walton T, Szostak JW
J Am Chem Soc. 2016;138(36):11996-2002 - PMID: 27552367

Increased Intestinal Microbial Diversity Following Fecal Microbiota Transplant for Active Crohn's Disease.

Vaughn BP, Vatanen T, Allegretti JR, Bai A, Xavier RJ, Korzenik J, Gevers D, Ting A, Robson SC, Moss AC
Inflamm Bowel Dis. 2016;22(9):2182-90 - PMID: 27542133 - PMCID: PMC4995064

Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1.

Lehrbach NJ, Ruvkun G
Elife. 2016;5:ePub - PMID: 27528192 - PMCID: PMC4987142

Prevention of Burn-Induced Inflammatory Responses and Muscle Wasting By GTS-21, A Specific Agonist for ?7 Nicotinic Acetylcholine Receptors.

Kashiwagi S, Khan MA, Yasuhara S, Goto T, Tompkins RG, Kaneki M, Martyn JA
Shock. 2016;47(1):61-69 - PMID: 27529131 - PMCID: PMC5167674

A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis.

Rivas MA, Graham D, Sulem P, Stevens C, Desch AN, Goyette P, Gudbjartsson D, Jonsdottir I, Thorsteinsdottir U, Degenhardt F, Mucha S, Kurki MI, Li D, D'Amato M, Annese V, Vermeire S, Weersma RK, Halfvarson J, Paavola-Sakki P, Lappalainen M, Lek M, Cummings B, Tukiainen T, Haritunians T, Halme L, Koskinen LL, Ananthakrishnan AN, Luo Y, Heap GA, Visschedijk MC, , , MacArthur DG, Neale BM, Ahmad T, Anderson CA, Brant SR, Duerr RH, Silverberg MS, Cho JH, Palotie A, Saavalainen P, Kontula K, Fä ...
Nat Commun. 2016;7:12342 - PMID: 27503255 - PMCID: PMC4980482

A pleiotropic missense variant in SLC39A8 is associated with Crohn's disease and human gut microbiome composition.

Li D, Achkar JP, Haritunians T, Jacobs JP, Hui KY, D'Amato M, Brand S, Radford-Smith G, Halfvarson J, Niess JH, Kugathasan S, Büning C, Schumm LP, Klei L, Ananthakrishnan A, Aumais G, Baidoo L, Dubinsky M, Fiocchi C, Glas J, Milgrom R, Proctor DD, Regueiro M, Simms LA, Stempak JM, Targan SR, Törkvist L, Sharma Y, Devlin B, Borneman J, Hakonarson H, Xavier RJ, Daly M, Brant SR, Rioux JD, Silverberg MS, Cho JH, Braun J, McGovern DP, Duerr RH
Gastroenterology. 2016;151(4):724-32 - PMID: 27492617 - PMCID: PMC5037008

Understanding human immune function using the resources from the Human Functional Genomics Project.

Netea MG, Joosten LA, Li Y, Kumar V, Oosting M, Smeekens S, Jaeger M, Ter Horst R, Schirmer M, Vlamakis H, Notebaart R, Pavelka N, Aguirre-Gamboa RR, Swertz MA, Tunjungputri RN, van de Heijden W, Franzosa EA, Ng A, Graham D, Lassen K, Schraa K, Netea-Maier R, Smit J, de Mast Q, van de Veerdonk F, Kullberg BJ, Tack C, van de Munckhof I, Rutten J, van der Graaf J, Franke L, Hofker M, Jonkers I, Platteel M, Maatman A, Fu J, Zhernakova A, van der Meer JW, Dinarello CA, van der Ven A, Huttenhouwe ...
Nat Med. 2016;22(8):831-833 - PMID: 27490433

Accelerating global innovation to address antibacterial resistance: introducing CARB-X.

Outterson K, Rex JH, Jinks T, Jackson P, Hallinan J, Karp S, Hung DT, Franceschi F, Merkeley T, Houchens C, Dixon DM, Kurilla MG, Aurigemma R, Larsen J
Nat Rev Drug Discov. 2016;15(9):589-90 - PMID: 27469032

Molecular Imaging of Smoke-Induced Changes in Nuclear Factor-Kappa B Expression in Murine Tissues Including the Lung.

Syrkina O, Hales CH, Bonab AA, Hamrahi V, Paul K, Jung WJ, Tompkins RG, Fischman AJ, Carter EA
J Burn Care Res. 2016;37(6):335-342 - PMID: 27437954

A highly multiplexed and sensitive RNA-seq protocol for simultaneous analysis of host and pathogen transcriptomes.

Avraham R, Haseley N, Fan A, Bloom-Ackermann Z, Livny J, Hung DT
Nat Protoc. 2016;11(8):1477-1491 - PMID: 27442864

Dysbiosis, inflammation, and response to treatment: a longitudinal study of pediatric subjects with newly diagnosed inflammatory bowel disease.

Shaw KA, Bertha M, Hofmekler T, Chopra P, Vatanen T, Srivatsa A, Prince J, Kumar A, Sauer C, Zwick ME, Satten GA, Kostic AD, Mulle JG, Xavier RJ, Kugathasan S
Genome Med. 2016;8(1):75 - PMID: 27412252 - PMCID: PMC4944441

A microRNA program in the C. elegans hypodermis couples to intestinal mTORC2/PQM-1 signaling to modulate fat transport.

Dowen RH, Breen PC, Tullius T, Conery AL, Ruvkun G
Genes Dev. 2016;30(13):1515-28 - PMID: 27401555 - PMCID: PMC4949325

Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi.

Li Y, Oosting M, Deelen P, Ricaño-Ponce I, Smeekens S, Jaeger M, Matzaraki V, Swertz MA, Xavier RJ, Franke L, Wijmenga C, Joosten LA, Kumar V, Netea MG
Nat Med. 2016;22(8):952-960 - PMID: 27376574 - PMCID: PMC5084084

Introduction to Gene Editing and Manipulation Using CRISPR/Cas9 Technology.

Newman M, Ausubel FM
Curr Protoc Mol Biol. 2016;115:31.4.1-6 - PMID: 27366890 - PMCID: PMC4963815

Nonenzymatic copying of RNA templates containing all four letters is catalyzed by activated oligonucleotides.

Prywes N, Blain JC, Del Frate F, Szostak JW
Elife. 2016;5:ePub - PMID: 27351102 - PMCID: PMC4959843

Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62.

DeJesus R, Moretti F, McAllister G, Wang Z, Bergman P, Liu S, Frias E, Alford J, Reece-Hoyes JS, Lindeman A, Kelliher J, Russ C, Knehr J, Carbone W, Beibel M, Roma G, Ng A, Tallarico JA, Porter JA, Xavier RJ, Mickanin C, Murphy LO, Hoffman GR, Nyfeler B
Elife. 2016;5:ePub - PMID: 27351204 - PMCID: PMC4924995

Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells.

Kleinstiver BP, Tsai SQ, Prew MS, Nguyen NT, Welch MM, Lopez JM, McCaw ZR, Aryee MJ, Joung JK
Nat Biotechnol. 2016;34(8):869-874 - PMID: 27347757 - PMCID: PMC4980201

Microbiota as Therapeutic Targets.

Xavier RJ
Dig Dis. 2016;34(5):558-565 - PMID: 27331403

Baeyer-Villiger Monooxygenases EthA and MymA Are Required for Activation of Replicating and Non-replicating Mycobacterium tuberculosis Inhibitors.

Grant SS, Wellington S, Kawate T, Desjardins CA, Silvis MR, Wivagg C, Thompson M, Gordon K, Kazyanskaya E, Nietupski R, Haseley N, Iwase N, Earl AM, Fitzgerald M, Hung DT
Cell Chem Biol. 2016;23(6):666-77 - PMID: 27321573 - PMCID: PMC4920728

Caenorhabditis elegans responses to bacteria from its natural habitats.

Samuel BS, Rowedder H, Braendle C, Félix MA, Ruvkun G
Proc Natl Acad Sci U S A. 2016;113(27):E3941-9 - PMID: 27317746 - PMCID: PMC4941482

Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability.

Yassour M, Vatanen T, Siljander H, Hämäläinen AM, Härkönen T, Ryhänen SJ, Franzosa EA, Vlamakis H, Huttenhower C, Gevers D, Lander ES, Knip M, , Xavier RJ
Sci Transl Med. 2016;8(343):343ra81 - PMID: 27306663 - PMCID: PMC5032909

Profiling DNA damage-induced phosphorylation in budding yeast reveals diverse signaling networks.

Zhou C, Elia AE, Naylor ML, Dephoure N, Ballif BA, Goel G, Xu Q, Ng A, Chou DM, Xavier RJ, Gygi SP, Elledge SJ
Proc Natl Acad Sci U S A. 2016;113(26):E3667-75 - PMID: 27298372 - PMCID: PMC4932963

Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk.

Lassen KG, McKenzie CI, Mari M, Murano T, Begun J, Baxt LA, Goel G, Villablanca EJ, Kuo SY, Huang H, Macia L, Bhan AK, Batten M, Daly MJ, Reggiori F, Mackay CR, Xavier RJ
Immunity. 2016;44(6):1392-1405 - PMID: 27287411 - PMCID: PMC4936415

The T300A Crohn's disease risk polymorphism impairs function of the WD40 domain of ATG16L1.

Boada-Romero E, Serramito-Gómez I, Sacristán MP, Boone DL, Xavier RJ, Pimentel-Muiños FX
Nat Commun. 2016;7:11821 - PMID: 27273576 - PMCID: PMC4899871

Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans.

Vatanen T, Kostic AD, d'Hennezel E, Siljander H, Franzosa EA, Yassour M, Kolde R, Vlamakis H, Arthur TD, Hämäläinen AM, Peet A, Tillmann V, Uibo R, Mokurov S, Dorshakova N, Ilonen J, Virtanen SM, Szabo SJ, Porter JA, Lähdesmäki H, Huttenhower C, Gevers D, Cullen TW, Knip M, , Xavier RJ
Cell. 2016;165(6):1551 - PMID: 27259157

Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease.

Chu H, Khosravi A, Kusumawardhani IP, Kwon AH, Vasconcelos AC, Cunha LD, Mayer AE, Shen Y, Wu WL, Kambal A, Targan SR, Xavier RJ, Ernst PB, Green DR, McGovern DP, Virgin HW, Mazmanian SK
Science. 2016;352(6289):1116-20 - PMID: 27230380 - PMCID: PMC4996125

Isocitrate dehydrogenase mutations confer dasatinib hypersensitivity and SRC-dependence in intrahepatic cholangiocarcinoma.

Saha SK, Gordan JD, Kleinstiver BP, Vu P, Najem MS, Yeo JC, Shi L, Kato Y, Levin RS, Webber JT, Damon LJ, Egan RK, Greninger P, McDermott U, Garnett MJ, Jenkins RL, Rieger-Christ KM, Sullivan TB, Hezel AF, Liss AS, Mizukami Y, Goyal L, Ferrone CR, Zhu AX, Joung JK, Shokat KM, Benes CH, Bardeesy N
Cancer Discov. 2016;6(7):727-39 - PMID: 27231123 - PMCID: PMC5458737

Development of Chemical Probes for Investigation of Salt-Inducible Kinase Function In Vivo.

Sundberg TB, Liang Y, Wu H, Choi HG, Kim ND, Sim T, Johannessen L, Petrone A, Khor B, Graham DB, Latorre IJ, Phillips AJ, Schreiber SL, Perez J, Shamji AF, Gray NS, Xavier RJ
ACS Chem Biol. 2016;11(8):2105-11 - PMID: 27224444 - PMCID: PMC4992440

Simultaneous Pathway Activity Inference and Gene Expression Analysis Using RNA Sequencing.

O'Connell DJ, Kolde R, Sooknah M, Graham DB, Sundberg TB, Latorre IJ, Mikkelsen TS, Xavier RJ
Cell Syst. 2016;2(5):323-334 - PMID: 27211859 - PMCID: PMC5032147

Role of Elevated Fibrinogen in Burn-Induced Mitochondrial Dysfunction: Protective Effects of Glycyrrhizin.

Ueki R, Liu L, Kashiwagi S, Kaneki M, Khan M, Hirose M, Tompkins RG, Martyn JA, Yasuhara S
Shock. 2016;46(4):382-9 - PMID: 27172157 - PMCID: PMC5026541

Coagulation Biomarkers in Healthy Chinese-Origin Rhesus Macaques (Macaca mulatta).

Frydman GH, Bendapudi PK, Marini RP, Vanderburg CR, Tompkins RG, Fox JG
J Am Assoc Lab Anim Sci. 2016;55(3):252-9 - PMID: 27177557 - PMCID: PMC4865685

Mechanisms of Pediatric Inflammatory Bowel Disease.

Peloquin JM, Goel G, Villablanca EJ, Xavier RJ
Annu Rev Immunol. 2016;34:31-64 - PMID: 27168239

CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands.

Lamas B, Richard ML, Leducq V, Pham HP, Michel ML, Da Costa G, Bridonneau C, Jegou S, Hoffmann TW, Natividad JM, Brot L, Taleb S, Couturier-Maillard A, Nion-Larmurier I, Merabtene F, Seksik P, Bourrier A, Cosnes J, Ryffel B, Beaugerie L, Launay JM, Langella P, Xavier RJ, Sokol H
Nat Med. 2016;22(6):598-605 - PMID: 27158904 - PMCID: PMC5087285

Open-source guideseq software for analysis of GUIDE-seq data.

Tsai SQ, Topkar VV, Joung JK, Aryee MJ
Nat Biotechnol. 2016;34(5):483 - PMID: 27153277

Clinical Activity and Quality of Life Indices Are Valid Across Ulcerative Colitis But Not Crohn's Disease Phenotypes.

Taleban S, Stewart KO, Li DK, Singh P, Pardi DS, Sturgeon HC, Yajnik V, Xavier RJ, Ananthakrishnan AN, Khalili H
Dig Dis Sci. 2016;61(9):2627-35 - PMID: 27142671 - PMCID: PMC4982770

Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans.

Vatanen T, Kostic AD, d'Hennezel E, Siljander H, Franzosa EA, Yassour M, Kolde R, Vlamakis H, Arthur TD, Hämäläinen AM, Peet A, Tillmann V, Uibo R, Mokurov S, Dorshakova N, Ilonen J, Virtanen SM, Szabo SJ, Porter JA, Lähdesmäki H, Huttenhower C, Gevers D, Cullen TW, Knip M, , Xavier RJ
Cell. 2016;165(4):842-53 - PMID: 27133167 - PMCID: PMC4950857

Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity.

Zhernakova A, Kurilshikov A, Bonder MJ, Tigchelaar EF, Schirmer M, Vatanen T, Mujagic Z, Vila AV, Falony G, Vieira-Silva S, Wang J, Imhann F, Brandsma E, Jankipersadsing SA, Joossens M, Cenit MC, Deelen P, Swertz MA, , Weersma RK, Feskens EJ, Netea MG, Gevers D, Jonkers D, Franke L, Aulchenko YS, Huttenhower C, Raes J, Hofker MH, Xavier RJ, Wijmenga C, Fu J
Science. 2016;352(6285):565-9 - PMID: 27126040 - PMCID: PMC5240844

Thiolated uridine substrates and templates improve the rate and fidelity of ribozyme-catalyzed RNA copying.

Prywes N, Michaels YS, Pal A, Oh SS, Szostak JW
Chem Commun (Camb). 2016;52(39):6529-32 - PMID: 27109314

Trained immunity: A program of innate immune memory in health and disease.

Netea MG, Joosten LA, Latz E, Mills KH, Natoli G, Stunnenberg HG, O'Neill LA, Xavier RJ
Science. 2016;352(6284):aaf1098 - PMID: 27102489 - PMCID: PMC5087274

A simple physical mechanism enables homeostasis in primitive cells.

Engelhart AE, Adamala KP, Szostak JW
Nat Chem. 2016;8(5):448-53 - PMID: 27102678 - PMCID: PMC4929987

Defining and improving the genome-wide specificities of CRISPR-Cas9 nucleases.

Tsai SQ, Joung JK
Nat Rev Genet. 2016;17(5):300-12 - PMID: 27087594

Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming.

Zimmer S, Grebe A, Bakke SS, Bode N, Halvorsen B, Ulas T, Skjelland M, De Nardo D, Labzin LI, Kerksiek A, Hempel C, Heneka MT, Hawxhurst V, Fitzgerald ML, Trebicka J, Björkhem I, Gustafsson JÅ, Westerterp M, Tall AR, Wright SD, Espevik T, Schultze JL, Nickenig G, Lütjohann D, Latz E
Sci Transl Med. 2016;8(333):333ra50 - PMID: 27053774 - PMCID: PMC4878149

ABCA7 Deficiency Accelerates Amyloid-? Generation and Alzheimer's Neuronal Pathology.

Sakae N, Liu CC, Shinohara M, Frisch-Daiello J, Ma L, Yamazaki Y, Tachibana M, Younkin L, Kurti A, Carrasquillo MM, Zou F, Sevlever D, Bisceglio G, Gan M, Fol R, Knight P, Wang M, Han X, Fryer JD, Fitzgerald ML, Ohyagi Y, Younkin SG, Bu G, Kanekiyo T
J Neurosci. 2016;36(13):3848-59 - PMID: 27030769 - PMCID: PMC4812140

Timothy C. Wang, MD: Our next AGA President.

Abrams JA, Xavier RJ, Rustgi AK
Gastroenterology. 2016;150(5):1231-6 - PMID: 27018487

Collaboration between primitive cell membranes and soluble catalysts.

Adamala KP, Engelhart AE, Szostak JW
Nat Commun. 2016;7:11041 - PMID: 26996603 - PMCID: PMC4802160

Mutation of the Glucosinolate Biosynthesis Enzyme Cytochrome P450 83A1 Monooxygenase Increases Camalexin Accumulation and Powdery Mildew Resistance.

Liu S, Bartnikas LM, Volko SM, Ausubel FM, Tang D
Front Plant Sci. 2016;7:227 - PMID: 26973671 - PMCID: PMC4774424

Experimental and computational evidence for a loose transition state in phosphoroimidazolide hydrolysis.

Li L, Lelyveld VS, Prywes N, Szostak JW
J Am Chem Soc. 2016;138(12):3986-3989 - PMID: 26974265

?v Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells.

Acharya M, Sokolovska A, Tam JM, Conway KL, Stefani C, Raso F, Mukhopadhyay S, Feliu M, Paul E, Savill J, Hynes RO, Xavier RJ, Vyas JM, Stuart LM, Lacy-Hulbert A
Nat Commun. 2016;7:10917 - PMID: 26965188 - PMCID: PMC4792966

Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann-Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease.

Schwerd T, Pandey S, Yang HT, Bagola K, Jameson E, Jung J, Lachmann RH, Shah N, Patel SY, Booth C, Runz H, Düker G, Bettels R, Rohrbach M, Kugathasan S, Chapel H, Keshav S, Elkadri A, Platt N, Muise AM, Koletzko S, Xavier RJ, Marquardt T, Powrie F, Wraith JE, Gyrd-Hansen M, Platt FM, Uhlig HH
Gut. 2016;66(6):1060-1073 - PMID: 26953272

Recovery Curves for Pediatric Burn Survivors: Advances in Patient-Oriented Outcomes.

Kazis LE, Lee AF, Rose M, Liang MH, Li NC, Ren XS, Sheridan R, Gilroy-Lewis J, Stoddard F, Hinson M, Warden G, Stubbs K, Blakeney P, Meyer W, McCauley R, Herndon D, Palmieri T, Mooney K, Wood D, Pidcock F, Reilly D, Cullen M, Calvert C, Ryan CM, Schneider JC, Soley-Bori M, Tompkins RG
JAMA Pediatr. 2016;170(6):534-542 - PMID: 26953515

New Regulatory Roles of Galectin-3 in the High-affinity IgE Receptor Signaling.

Bambouskova M, Polakovicova I, Halova I, Goel G, Draberova L, Bugajev V, Doan A, Utekal P, Gardet A, Xavier RJ, Draber P
Mol Cell Biol. 2016;36(9):1366-82 - PMID: 26929198 - PMCID: PMC4836217

NH125 kills methicillin-resistant Staphylococcus aureus persisters by lipid bilayer disruption.

Kim W, Fricke N, Conery AL, Fuchs BB, Rajamuthiah R, Jayamani E, Vlahovska PM, Ausubel FM, Mylonakis E
Future Med Chem. 2016;8(3):257-69 - PMID: 26910612 - PMCID: PMC4976882

Sub-clinical detection of gut microbial biomarkers of obesity and type 2 diabetes.

Yassour M, Lim MY, Yun HS, Tickle TL, Sung J, Song YM, Lee K, Franzosa EA, Morgan XC, Gevers D, Lander ES, Xavier RJ, Birren BW, Ko G, Huttenhower C
Genome Med. 2016;8(1):17 - PMID: 26884067 - PMCID: PMC4756455

Synthesis of activated 3'-amino-3'-deoxy-2-thio-thymidine, a superior substrate for the nonenzymatic copying of nucleic acid templates.

Izgu EC, Oh SS, Szostak JW
Chem Commun (Camb). 2016;52(18):3684-6 - PMID: 26857159

Planetary Protection and Mars Special Regions-A Suggestion for Updating the Definition.

Rettberg P, Anesio AM, Baker VR, Baross JA, Cady SL, Detsis E, Foreman CM, Hauber E, Ori GG, Pearce DA, Renno NO, Ruvkun G, Sattler B, Saunders MP, Smith DH, Wagner D, Westall F
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On the Mechanism of Berberine-INF55 (5-Nitro-2-phenylindole) Hybrid Antibacterials.

Dolla NK, Chen C, Larkins-Ford J, Rajamuthiah R, Jagadeesan S, Conery AL, Ausubel FM, Mylonakis E, Bremner JB, Lewis K, Kelso MJ
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, A ...
Autophagy. 2016;12(1):1-222 - PMID: 26799652 - PMCID: PMC4835977

The burn outcome questionnaires: Patient and family reported outcome metrics for children of all ages.

Ryan CM, Cartwright S, Schneider JC, Tompkins RG, Kazis LE
Burns. 2016;42(5):1144-5 - PMID: 26803370

Hold the Pendulum: Rates of Acute Kidney Injury are Increased in Patients Who Receive Resuscitation Volumes Less than Predicted by the Parkland Equation.

Mason SA, Nathens AB, Finnerty CC, Gamelli RL, Gibran NS, Arnoldo BD, Tompkins RG, Herndon DN, Jeschke MG,
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Loss of a Class A Penicillin-Binding Protein Alters ?-Lactam Susceptibilities in Mycobacterium tuberculosis.

Wivagg CN, Wellington S, Gomez JE, Hung DT
ACS Infect Dis. 2015;2(2):104-10 - PMID: 27624961

Associations with rhizosphere bacteria can confer an adaptive advantage to plants.

Haney CH, Samuel BS, Bush J, Ausubel FM
Nat Plants. 2015;1:15051 - PMID: 27250003

Jasmonate signalling in Arabidopsis involves SGT1b-HSP70-HSP90 chaperone complexes.

Zhang XC, Millet YA, Cheng Z, Bush J, Ausubel FM
Nat Plants. 2015;1:ePub - PMID: 27054042 - PMCID: PMC4819967

Associations with rhizosphere bacteria can confer an adaptive advantage to plants.

Haney CH, Samuel BS, Bush J, Ausubel FM
Nat Plants. 2015;1(6):ePub - PMID: 27019743 - PMCID: PMC4806546

Quantifying Risk Factors for Long-Term Sleep Problems After Burn Injury in Young Adults.

Lee AF, Ryan CM, Schneider JC, Kazis LE, Li NC, Rose M, Liang MH, Wang C, Palmieri T, Meyer WJ, Pidcock FS, Reilly D, Sheridan RL, Tompkins RG,
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Mouse embryonic fibroblasts exhibit extensive developmental and phenotypic diversity.

Singhal PK, Sassi S, Lan L, Au P, Halvorsen SC, Fukumura D, Jain RK, Seed B
Proc Natl Acad Sci U S A. 2015;113(1):122-7 - PMID: 26699463 - PMCID: PMC4711836

Proton pump inhibitors affect the gut microbiome.

Imhann F, Bonder MJ, Vich Vila A, Fu J, Mujagic Z, Vork L, Tigchelaar EF, Jankipersadsing SA, Cenit MC, Harmsen HJ, Dijkstra G, Franke L, Xavier RJ, Jonkers D, Wijmenga C, Weersma RK, Zhernakova A
Gut. 2015;65(5):740-8 - PMID: 26657899 - PMCID: PMC4853569

In vivo high-resolution magic angle spinning magnetic and electron paramagnetic resonance spectroscopic analysis of mitochondria-targeted peptide in Drosophila melanogaster with trauma-induced thoracic injury.

Constantinou C, Apidianakis Y, Psychogios N, Righi V, Mindrinos MN, Khan N, Swartz HM, Szeto HH, Tompkins RG, Rahme LG, Tzika AA
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Accelerating research through reagent repositories: the genome editing example.

Joung JK, Voytas DF, Kamens J
Genome Biol. 2015;16(1):255 - PMID: 26585970 - PMCID: PMC4653914

Pinpointing RNA-protein crosslinks with site-specific stable isotope labeled oligonucleotides.

Lelyveld VS, Bjorkbom A, Ransey E, Sliz P, Szostak JW
J Am Chem Soc. 2015;137(49):15378-15381 - PMID: 26583201 - PMCID: PMC4697197

Flow Cytometric Analysis of Mononuclear Phagocytes in Non-diseased Human Lung and Lung-draining Lymph Nodes.

Desch AN, Gibbings SL, Goyal R, Kolde R, Bednarek J, Bruno T, Slansky JE, Jacobelli J, Mason R, Ito Y, Messier E, Randolph GJ, Prabagar M, Atif SM, Segura E, Xavier RJ, Bratton DL, Janssen WJ, Henson PM, Jakubzick CV
Am J Respir Crit Care Med. 2015;193(6):614-626 - PMID: 26551758 - PMCID: PMC4824940

Early Leukocyte Gene Expression Associated with Age, Burn Size, and Inhalation Injury in Severely Burned Adults.

Sood RF, Gibran NS, Arnoldo BD, Gamelli RL, Herndon DN, Tompkins RG, Inflammation T, Investigators TH
J Trauma Acute Care Surg. 2015;80(2):250-7 - PMID: 26517785 - PMCID: PMC4731271

Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition.

Kleinstiver BP, Prew MS, Tsai SQ, Nguyen NT, Topkar VV, Zheng Z, Joung JK
Nat Biotechnol. 2015;33(12):1293-1298 - PMID: 26524662 - PMCID: PMC4689141

Kidney and Liver Injuries After Major Burns in Rats Are Prevented by Resolvin D2.

Inoue Y, Yu YM, Kurihara T, Vasilyev A, Ibrahim A, Oklu R, Zhao G, Nair AV, Brown D, Fischman AJ, Tompkins RG, Irimia D
Crit Care Med. 2015;44(5):e241-52 - PMID: 26509319 - PMCID: PMC4833510

LXR agonism up-regulates the macrophage ABCA1/syntrophin protein complex which can bind apoA-I and stabilized ABCA1 protein, but complex loss does not inhibit lipid efflux.

Tamehiro N, Park MH, Hawxhurst V, Nagpal K, Adams ME, Zannis VI, Golenbock DT, Fitzgerald ML
Biochemistry. 2015;54(46):6931-41 - PMID: 26506427 - PMCID: PMC4874254

Bidirectional direct sequencing of non-canonical RNA by two-dimensional analysis of mass chromatograms.

Bjorkbom A, Lelyveld VS, Zhang S, Zhang W, Tam CP, Blain JC, Szostak JW
J Am Chem Soc. 2015;137(45):14430-14438 - PMID: 26495937

Gene Expression of Proresolving Lipid Mediator Pathways Is Associated With Clinical Outcomes in Trauma Patients.

Orr SK, Butler KL, Hayden D, Tompkins RG, Serhan CN, Irimia D
Crit Care Med. 2015;43(12):2642-2650 - PMID: 26488221 - PMCID: PMC4651815

Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated Anti-fungal Immunity and Intestinal Inflammation.

Cao Z, Conway KL, Heath RJ, Rush JS, Leshchiner ES, Ramirez-Ortiz ZG, Nedelsky NB, Huang H, Ng A, Gardet A, Cheng SC, Shamji AF, Rioux JD, Wijmenga C, Netea MG, Means TK, Daly MJ, Xavier RJ
Immunity. 2015;43(4):715-726 - PMID: 26488816 - PMCID: PMC4672733

Novel links in the plant TOR kinase signaling network.

Xiong Y, Sheen J
Curr Opin Plant Biol. 2015;28:83-91 - PMID: 26476687 - PMCID: PMC4612364

Antibacterial properties of 3-(phenylsulfonyl)-2-pyrazinecarbonitrile.

Rajamuthiah R, Jayamani E, Majed H, Conery AL, Kim W, Kwon B, Fuchs BB, Kelso MJ, Ausubel FM, Mylonakis E
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Genome Editing in Human Cells Using CRISPR/Cas Nucleases.

Wyvekens N, Tsai SQ, Joung JK
Curr Protoc Mol Biol. 2015;112:31.3.1-31.3.18 - PMID: 26423589 - PMCID: PMC4852847

Pathogen Cell-to-Cell Variability Drives Heterogeneity in Host Immune Responses.

Avraham R, Haseley N, Brown D, Penaranda C, Jijon HB, Trombetta JJ, Satija R, Shalek AK, Xavier RJ, Regev A, Hung DT
Cell. 2015;162(6):1309-21 - PMID: 26343579 - PMCID: PMC4578813

A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-?-Activated Human Cells.

Selleck EM, Orchard RC, Lassen KG, Beatty WL, Xavier RJ, Levine B, Virgin HW, Sibley LD
MBio. 2015;6(5):e01157-15 - PMID: 26350966 - PMCID: PMC4600106

The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood Lipids.

Fu J, Bonder MJ, Cenit MC, Tigchelaar E, Maatman A, Dekens JA, Brandsma E, Marczynska J, Imhann F, Weersma RK, Franke L, Poon TW, Xavier RJ, Gevers D, Hofker MH, Wijmenga C, Zhernakova A
Circ Res. 2015;117(9):817-24 - PMID: 26358192 - PMCID: PMC4596485

Dialogue between E. coli free radical pathways and the mitochondria of C. elegans.

Govindan JA, Jayamani E, Zhang X, Mylonakis E, Ruvkun G
Proc Natl Acad Sci U S A. 2015;112(40):12456-61 - PMID: 26392561 - PMCID: PMC4603447

CAUSEL: an epigenome- and genome-editing pipeline for establishing function of noncoding GWAS variants.

Spisák S, Lawrenson K, Fu Y, Csabai I, Cottman RT, Seo JH, Haiman C, Han Y, Lenci R, Li Q, Tisza V, Szállási Z, Herbert ZT, Chabot M, Pomerantz M, Solymosi N, , Gayther SA, Joung JK, Freedman ML
Nat Med. 2015;21(11):1357-1363 - PMID: 26398868 - PMCID: PMC4746056

Enhancing immunity by engineering DAMPs.

Cervone F, Ausubel FM, Lorenzo G
Oncotarget. 2015;6(30):28523-4 - PMID: 26387132 - PMCID: PMC4745668

Patiromer induces rapid and sustained potassium lowering in patients with chronic kidney disease and hyperkalemia.

Bushinsky DA, Williams GH, Pitt B, Weir MR, Freeman MW, Garza D, Stasiv Y, Li E, Berman L, Bakris GL
Kidney Int. 2015;88(6):1427-1433 - PMID: 26376130 - PMCID: PMC4678168

A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-?-Activated Human Cells.

Selleck EM, Orchard RC, Lassen KG, Beatty WL, Xavier RJ, Levine B, Virgin HW, Sibley LD
MBio. 2015;6(5):e01157-15 - PMID: 26350966 - PMCID: PMC4600106

Pathogen Cell-to-Cell Variability Drives Heterogeneity in Host Immune Responses.

Avraham R, Haseley N, Brown D, Penaranda C, Jijon HB, Trombetta JJ, Satija R, Shalek AK, Xavier RJ, Regev A, Hung DT
Cell. 2015;162(6):1309-21 - PMID: 26343579 - PMCID: PMC4578813

HIV infection induces structural and functional changes in high density lipoproteins.

Siegel MO, Borkowska AG, Dubrovsky L, Roth M, Welti R, Roberts AD, Parenti DM, Simon GL, Sviridov D, Simmens S, Bukrinsky M, Fitzgerald ML
Atherosclerosis. 2015;243(1):19-29 - PMID: 26343868 - PMCID: PMC4609619

ConStrains identifies microbial strains in metagenomic datasets.

Luo C, Knight R, Siljander H, Knip M, Xavier RJ, Gevers D
Nat Biotechnol. 2015;33(10):1045-1052 - PMID: 26344404 - PMCID: PMC4676274

Lipid signalling couples translational surveillance to systemic detoxification in Caenorhabditis elegans.

Govindan JA, Jayamani E, Zhang X, Breen P, Larkins-Ford J, Mylonakis E, Ruvkun G
Nat Cell Biol. 2015;17(10):1294-303 - PMID: 26322678 - PMCID: PMC4589496

MICROBIOME. Plant microbiome blueprints.

Haney CH, Ausubel FM
Science. 2015;349(6250):788-9 - PMID: 26293938

piRNAs and piRNA-Dependent siRNAs Protect Conserved and Essential C. elegans Genes from Misrouting into the RNAi Pathway.

Phillips CM, Brown KC, Montgomery BE, Ruvkun G, Montgomery TA
Dev Cell. 2015;34(4):457-465 - PMID: 26279487 - PMCID: PMC4550515

Is Real-Time Feedback of Burn-Specific Patient-Reported Outcome Measures in Clinical Settings Practical and Useful? A Pilot Study Implementing the Young Adult Burn Outcome Questionnaire.

Ryan CM, Lee AF, Kazis LE, Shapiro GD, Schneider JC, Goverman J, Fagan SP, Wang C, Kim J, Sheridan RL, Tompkins RG
J Burn Care Res. 2015;37(1):64-74 - PMID: 26284638

Continuous directed evolution of DNA-binding proteins to improve TALEN specificity.

Hubbard BP, Badran AH, Zuris JA, Guilinger JP, Davis KM, Chen L, Tsai SQ, Sander JD, Joung JK, Liu DR
Nat Methods. 2015;12(10):939-942 - PMID: 26258293 - PMCID: PMC4589463

Growth dynamics of gut microbiota in health and disease inferred from single metagenomic samples.

Korem T, Zeevi D, Suez J, Weinberger A, Avnit-Sagi T, Pompan-Lotan M, Matot E, Jona G, Harmelin A, Cohen N, Sirota-Madi A, Thaiss CA, Pevsner-Fischer M, Sorek R, Xavier R, Elinav E, Segal E
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Thermodynamic insights into 2-thiouridine-enhanced RNA hybridization.

Larsen AT, Fahrenbach AC, Sheng J, Pian J, Szostak JW
Nucleic Acids Res. 2015;43(16):7675-87 - PMID: 26240387 - PMCID: PMC4652770

Common Genetic Variants Influence Circulating Vitamin D Levels in Inflammatory Bowel Diseases.

Ananthakrishnan AN, Cagan A, Cai T, Gainer VS, Shaw SY, Churchill S, Karlson EW, Murphy SN, Kohane I, Liao KP, Xavier RJ
Inflamm Bowel Dis. 2015;21(11):2507-2514 - PMID: 26241000 - PMCID: PMC4615315

Electrostatic Localization of RNA to Protocell Membranes by Cationic Hydrophobic Peptides.

Kamat NP, Tobé S, Hill IT, Szostak JW
Angew Chem Int Ed Engl. 2015;54(40):11735-11739 - PMID: 26223820 - PMCID: PMC4600236

Identification of an anti-inflammatory protein from Faecalibacterium prausnitzii, a commensal bacterium deficient in Crohn's disease.

Quévrain E, Maubert MA, Michon C, Chain F, Marquant R, Tailhades J, Miquel S, Carlier L, Bermúdez-Humarán LG, Pigneur B, Lequin O, Kharrat P, Thomas G, Rainteau D, Aubry C, Breyner N, Afonso C, Lavielle S, Grill JP, Chassaing G, Chatel JM, Trugnan G, Xavier R, Langella P, Sokol H, Seksik P
Gut. 2015;65(3):415-25 - PMID: 26045134 - PMCID: PMC5136800

Pseudomonas syringae enhances herbivory by suppressing the reactive oxygen burst in Arabidopsis.

Groen SC, Humphrey PT, Chevasco D, Ausubel FM, Pierce NE, Whiteman NK
J Insect Physiol. 2015;84:90-102 - PMID: 26205072 - PMCID: PMC4721946

Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst.

Graham DB, Becker CE, Doan A, Goel G, Villablanca EJ, Knights D, Mok A, Ng AC, Doench JG, Root DE, Clish CB, Xavier RJ
Nat Commun. 2015;6:7838 - PMID: 26194095 - PMCID: PMC4518307

Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics.

Kuo SY, Castoreno AB, Aldrich LN, Lassen KG, Goel G, Dan?ík V, Kuballa P, Latorre I, Conway KL, Sarkar S, Maetzel D, Jaenisch R, Clemons PA, Schreiber SL, Shamji AF, Xavier RJ
Proc Natl Acad Sci U S A. 2015;112(31):E4281-7 - PMID: 26195741 - PMCID: PMC4534235

Body Mass Index, Genetic Susceptibility, and Risk of Complications Among Individuals with Crohn's Disease.

Pringle PL, Stewart KO, Peloquin JM, Sturgeon HC, Nguyen D, Sauk J, Garber JJ, Yajnik V, Ananthakrishnan AN, Chan AT, Xavier RJ, Khalili H
Inflamm Bowel Dis. 2015;21(10):2304-2310 - PMID: 26181430 - PMCID: PMC4567407

Role of Autophagy in the Maintenance of Intestinal Homeostasis.

Baxt LA, Xavier RJ
Gastroenterology. 2015;149(3):553-62 - PMID: 26170139 - PMCID: PMC4550567

Effect of Patiromer on Serum Potassium Level in Patients With Hyperkalemia and Diabetic Kidney Disease: The AMETHYST-DN Randomized Clinical Trial.

Bakris GL, Pitt B, Weir MR, Freeman MW, Mayo MR, Garza D, Stasiv Y, Zawadzki R, Berman L, Bushinsky DA,
JAMA. 2015;314(2):151-161 - PMID: 26172895

Unwanted mutations: Standards needed for gene-editing errors.

Joung JK
Nature. 2015;523(7559):158 - PMID: 26156364

Stimulation of Liver X Receptor Has Potent Anti-HIV Effects in a Humanized Mouse Model.

Ramezani A, Dubrovsky L, Pushkarsky T, Sviridov D, Karandish S, Raj DS, Fitzgerald ML, Bukrinsky M
J Pharmacol Exp Ther. 2015;354(3):376-83 - PMID: 26126533 - PMCID: PMC4538872

Integrated Genomics of Crohn's Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy.

Begun J, Lassen KG, Jijon HB, Baxt LA, Goel G, Heath RJ, Ng A, Tam JM, Kuo SY, Villablanca EJ, Fagbami L, Oosting M, Kumar V, Schenone M, Carr SA, Joosten LA, Vyas JM, Daly MJ, Netea MG, Brown GD, Wijmenga C, Xavier RJ
Cell Rep. 2015;11(12):1905-1918 - PMID: 26095365 - PMCID: PMC4507440

Engineered CRISPR-Cas9 nucleases with altered PAM specificities.

Kleinstiver BP, Prew MS, Tsai SQ, Topkar VV, Nguyen NT, Zheng Z, Gonzales AP, Li Z, Peterson RT, Yeh JJ, Aryee MJ, Joung JK
Nature. 2015;523(7561):481-5 - PMID: 26098369 - PMCID: PMC4540238

Dimeric CRISPR RNA-guided FokI-dCas9 nucleases (RFNs) directed by truncated gRNAs for highly specific genome editing.

Wyvekens N, Topkar VV, Khayter C, Joung JK, Tsai SQ
Hum Gene Ther. 2015;26(7):425-431 - PMID: 26068112 - PMCID: PMC4509490

A Defensin from the Model Beetle Tribolium castaneum Acts Synergistically with Telavancin and Daptomycin against Multidrug Resistant Staphylococcus aureus.

Rajamuthiah R, Jayamani E, Conery AL, Fuchs BB, Kim W, Johnston T, Vilcinskas A, Ausubel FM, Mylonakis E
PLoS One. 2015;10(6):e0128576 - PMID: 26062137 - PMCID: PMC4465704

CARMA3 Is Critical for the Initiation of Allergic Airway Inflammation.

Causton B, Ramadas RA, Cho JL, Jones K, Pardo-Saganta A, Rajagopal J, Xavier RJ, Medoff BD
J Immunol. 2015;195(2):683-94 - PMID: 26041536 - PMCID: PMC4489191

Identification of an Antimicrobial Agent Effective against Methicillin-Resistant Staphylococcus aureus Persisters Using a Fluorescence-Based Screening Strategy.

Kim W, Conery AL, Rajamuthiah R, Fuchs BB, Ausubel FM, Mylonakis E
PLoS One. 2015;10(6):e0127640 - PMID: 26039584 - PMCID: PMC4454602

Construction of a liposome dialyzer for the preparation of high-value, small-volume liposome formulations.

Adamala K, Engelhart AE, Kamat NP, Jin L, Szostak JW
Nat Protoc. 2015;10(6):927-938 - PMID: 26020615 - PMCID: PMC4982460

Hypoxia drives transient site-specific copy gain and drug-resistant gene expression.

Black JC, Atabakhsh E, Kim J, Biette KM, Van Rechem C, Ladd B, Burrowes PD, Donado C, Mattoo H, Kleinstiver BP, Song B, Andriani G, Joung JK, Iliopoulos O, Montagna C, Pillai S, Getz G, Whetstine JR
Genes Dev. 2015;29(10):1018-31 - PMID: 25995187 - PMCID: PMC4441050

The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells.

Khor B, Gagnon JD, Goel G, Roche MI, Conway KL, Tran K, Aldrich LN, Sundberg TB, Paterson AM, Mordecai S, Dombkowski D, Schirmer M, Tan PH, Bhan AK, Roychoudhuri R, Restifo NP, O'Shea JJ, Medoff BD, Shamji AF, Schreiber SL, Sharpe AH, Shaw SY, Xavier RJ
Elife. 2015;4:ePub - PMID: 25998054 - PMCID: PMC4441007

Rescue of DNA-PK Signaling and T-Cell Differentiation by Targeted Genome Editing in a prkdc Deficient iPSC Disease Model.

Rahman SH, Kuehle J, Reimann C, Mlambo T, Alzubi J, Maeder ML, Riedel H, Fisch P, Cantz T, Rudolph C, Mussolino C, Joung JK, Schambach A, Cathomen T
PLoS Genet. 2015;11(5):e1005239 - PMID: 26000857 - PMCID: PMC4441453

Targeted Mutagenesis in Zebrafish Using CRISPR RNA-Guided Nucleases.

Hwang WY, Fu Y, Reyon D, Gonzales AP, Joung JK, Yeh JR
Methods Mol Biol. 2015;1311:317-34 - PMID: 25981483

An Integrative View of Microbiome-Host Interactions in Inflammatory Bowel Diseases.

Wlodarska M, Kostic AD, Xavier RJ
Cell Host Microbe. 2015;17(5):577-591 - PMID: 25974300 - PMCID: PMC4498258

PhyloGene server for identification and visualization of co-evolving proteins using normalized phylogenetic profiles.

Sadreyev IR, Ji F, Cohen E, Ruvkun G, Tabach Y
Nucleic Acids Res. 2015;43(W1):W154-W159 - PMID: 25958392 - PMCID: PMC4489270

Genome editing technologies: defining a path to clinic.

Corrigan-Curay J, O'Reilly M, Kohn DB, Cannon PM, Bao G, Bushman FD, Carroll D, Cathomen T, Joung JK, Roth D, Sadelain M, Scharenberg AM, von Kalle C, Zhang F, Jambou R, Rosenthal E, Hassani M, Singh A, Porteus MH
Mol Ther. 2015;23(5):796-806 - PMID: 25943494 - PMCID: PMC4427885

Do standard burn mortality formulae work on a population of severely burned children and adults?

Tsurumi A, Que YA, Yan S, Tompkins RG, Rahme LG, Ryan CM
Burns. 2015;41(5):935-45 - PMID: 25922299

Uncovering the Thermodynamics of Monomer Binding for RNA Replication.

Izgu EC, Fahrenbach AC, Zhang N, Li L, Zhang W, Larsen A, Blain JC, Szostak JW
J Am Chem Soc. 2015;137(19):6373-82 - PMID: 25901790 - PMCID: PMC4984997

Repurposing Salicylanilide Anthelmintic Drugs to Combat Drug Resistant Staphylococcus aureus.

Rajamuthiah R, Fuchs BB, Conery AL, Kim W, Jayamani E, Kwon B, Ausubel FM, Mylonakis E
PLoS One. 2015;10(4):e0124595 - PMID: 25897961 - PMCID: PMC4405337

Direct detection and drug-resistance profiling of bacteremias using inertial microfluidics.

Hou HW, Bhattacharyya RP, Hung DT, Han J
Lab Chip. 2015;15(10):2297-2307 - PMID: 25882432 - PMCID: PMC4437799

Future Translational Applications From the Contemporary Genomics Era: A Scientific Statement From the American Heart Association.

Fox CS, Hall JL, Arnett DK, Ashley EA, Delles C, Engler MB, Freeman MW, Johnson JA, Lanfear DE, Liggett SB, Lusis AJ, Loscalzo J, MacRae CA, Musunuru K, Newby LK, O'Donnell CJ, Rich SS, Terzic A
Circulation. 2015;131(19):1715-36 - PMID: 25882488 - PMCID: PMC4825323

Associations between host gene expression, the mucosal microbiome, and clinical outcome in the pelvic pouch of patients with inflammatory bowel disease.

Morgan XC, Kabakchiev B, Waldron L, Tyler AD, Tickle TL, Milgrom R, Stempak JM, Gevers D, Xavier RJ, Silverberg MS, Huttenhower C
Genome Biol. 2015;16(1):67 - PMID: 25887922 - PMCID: PMC4414286

Plant immunity triggered by engineered in vivo release of oligogalacturonides, damage-associated molecular patterns.

Benedetti M, Pontiggia D, Raggi S, Cheng Z, Scaloni F, Ferrari S, Ausubel FM, Cervone F, De Lorenzo G
Proc Natl Acad Sci U S A. 2015;112(17):5533-8 - PMID: 25870275 - PMCID: PMC4418913

Discovery of a Small-Molecule Probe for V-ATPase Function.

Aldrich LN, Kuo SY, Castoreno AB, Goel G, Kuballa P, Rees MG, Seashore-Ludlow BA, Cheah JH, Latorre IJ, Schreiber SL, Shamji AF, Xavier RJ
J Am Chem Soc. 2015;137(16):5563-8 - PMID: 25860544 - PMCID: PMC4416280

Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells.

Liao J, Karnik R, Gu H, Ziller MJ, Clement K, Tsankov AM, Akopian V, Gifford CA, Donaghey J, Galonska C, Pop R, Reyon D, Tsai SQ, Mallard W, Joung JK, Rinn JL, Gnirke A, Meissner A
Nat Genet. 2015;47(5):469-78 - PMID: 25822089 - PMCID: PMC4414868

Intake of farmed Atlantic salmon fed soybean oil increases hepatic levels of arachidonic acid-derived oxylipins and ceramides in mice.

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The Dynamics of the Human Infant Gut Microbiome in Development and in Progression toward Type 1 Diabetes.

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Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa.

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Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease.

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Pyruvate Kinase M2 Regulates Hif-1? Activity and IL-1? Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages.

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Toddler: an embryonic signal that promotes cell movement via Apelin receptors.

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An improved predictive recognition model for Cys(2)-His(2) zinc finger proteins.

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Targeted mutagenesis of zebrafish antithrombin III triggers disseminated intravascular coagulation and thrombosis, revealing insight into function.

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A Zebrafish Model of Myelodysplastic Syndrome Produced Through tet2 Genomic Editing.

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Fanconi Anemia Gene Editing by the CRISPR/Cas9 System.

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Corrigendum: MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability.

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Recovery Trajectories After Burn Injury in Young Adults: Does Burn Size Matter?

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Early life environment and natural history of inflammatory bowel diseases.

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Spontaneous Neutrophil Migration Patterns during Sepsis after Major Burns.

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Gene Pathways That Delay Caenorhabditis elegans Reproductive Senescence.

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BCG-induced trained immunity in NK cells: Role for non-specific protection to infection.

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Cas9-Based Genome Editing in Arabidopsis and Tobacco.

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Autophagy and checkpoints for intracellular pathogen defense.

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Autophagy Controls BCG-Induced Trained Immunity and the Response to Intravesical BCG Therapy for Bladder Cancer.

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Chain-Length Heterogeneity Allows for the Assembly of Fatty Acid Vesicles in Dilute Solutions.

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Next-Gen Sequencing-Based Mapping and Identification of Ethyl Methanesulfonate-Induced Mutations in Arabidopsis thaliana.

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An Image-Based Genetic Assay Identifies Genes in T1D Susceptibility Loci Controlling Cellular Antiviral Immunity in Mouse.

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mTOR- and HIF-1?-mediated aerobic glycolysis as metabolic basis for trained immunity.

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Treatment of heterotopic ossification through remote ATP hydrolysis.

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Transmembrane adaptor protein PAG/CBP is involved in both positive and negative regulation of mast cell signaling.

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Small-molecule control of cytokine function: new opportunities for treating immune disorders.

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Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidaemia.

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Crystal Structure Studies of RNA Duplexes Containing s2U:A and s2U:U Base Pairs.

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Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation.

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HIV-1 Protein Nef Inhibits Activity of ATP Binding Cassette Transporter A1 by Targeting Endoplasmic Reticulum Chaperone Calnexin.

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Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells.

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Single Hind Limb Burn Injury to Mice Alters Nuclear Factor-?B Expression and [18F] 2-Fluoro-2-Deoxy-D-Glucose Uptake.

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Apoplastic peroxidases are required for salicylic acid-mediated defense against Pseudomonas syringae.

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On the Horizon: Research Priorities in Burns for the Next Decade.

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Mechanisms of ?-lactam killing and resistance in the context of Mycobacterium tuberculosis.

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Identification of genes in toxicity pathways of trinucleotide-repeat RNA in C. elegans.

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Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature.

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AGROBEST: an efficient Agrobacterium-mediated transient expression method for versatile gene function analyses in Arabidopsis seedlings.

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Inflammatory Bowel Disease as a Model for Translating the Microbiome.

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Prediction of Multiple Infections After Severe Burn Trauma: A Prospective Cohort Study.

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Simvastatin Reduces Burn Injury-Induced Splenic Apoptosis via Downregulation of the TNF-?/NF-?B Pathway.

Zhao G, Yu YM, Kaneki M, Bonab AA, Tompkins RG, Fischman AJ
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SLCO3A1, a Novel Crohn's Disease-Associated Gene, Regulates NF-?B Activity and Associates with Intestinal Perforation.

Wei SC, Tan YY, Weng MT, Lai LC, Hsiao JH, Chuang EY, Shun CT, Wu DC, Kao AW, Chuang CS, Ni YH, Shieh MJ, Tung CC, Chen Y, Wang CY, Xavier RJ, Podolsky DK, Wong JM
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Detecting differential protein expression in large-scale population proteomics.

Ryu SY, Qian WJ, Camp DG, Smith RD, Tompkins RG, Davis RW, Xiao W
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The Evolutionarily Conserved Mediator Subunit MDT-15/MED15 Links Protective Innate Immune Responses and Xenobiotic Detoxification.

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PLoS Pathog. 2014;10(5):e1004143 - PMID: 24875643 - PMCID: PMC4038581

Deficits in receptor-mediated endocytosis and recycling in cells from mice bearing a disruption of the Gpr107 locus.

Zhou GL, Na SY, Niedra R, Seed B
J Cell Sci. 2014;127(Pt 18):3916-27 - PMID: 24849652

Dectin-1 dependent LC3 recruitment to phagosomes enhances fungicidal activity in macrophages.

Tam JM, Mansour MK, Khan NS, Seward M, Puranam S, Tanne A, Sokolovska A, Becker CE, Acharya M, Baird MA, Choi AM, Davidson MW, Segal BH, Lacy-Hulbert A, Stuart LM, Xavier RJ, Vyas JM
J Infect Dis. 2014;210(11):1844-54 - PMID: 24842831 - PMCID: PMC4271056

Pseudomonas aeruginosa PA14 Pathogenesis in Caenorhabditis elegans.

Kirienko NV, Cezairliyan BO, Ausubel FM, Powell JR
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Epinecidin-1 has immunomodulatory effects, facilitating its therapeutic use in a mouse model of Pseudomonas aeruginosa sepsis.

Pan CY, Chen JC, Sheen JF, Lin TL, Chen JY
Antimicrob Agents Chemother. 2014;58(8):4264-4274 - PMID: 24820078 - PMCID: PMC4135991

Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense.

Lassen KG, Kuballa P, Conway KL, Patel KK, Becker CE, Peloquin JM, Villablanca EJ, Norman JM, Liu TC, Heath RJ, Becker ML, Fagbami L, Horn H, Mercer J, Yilmaz OH, Jaffe JD, Shamji AF, Bhan AK, Carr SA, Daly MJ, Virgin HW, Schreiber SL, Stappenbeck TS, Xavier RJ
Proc Natl Acad Sci U S A. 2014;111(21):7741-7746 - PMID: 24821797 - PMCID: PMC4040621

In vivo high-resolution magic angle spinning proton NMR spectroscopy of Drosophila melanogaster flies as a model system to investigate mitochondrial dysfunction in Drosophila GST2 mutants.

Righi V, Apidianakis Y, Psychogios N, Rahme LG, Tompkins RG, Tzika AA
Int J Mol Med. 2014;34(1):327-33 - PMID: 24789699

Benchmarking outcomes in the critically injured burn patient.

Klein MB, Goverman J, Hayden DL, Fagan SP, McDonald-Smith GP, Alexander AK, Gamelli RL, Gibran NS, Finnerty CC, Jeschke MG, Arnoldo B, Wispelwey B, Mindrinos MN, Xiao W, Honari SE, Mason PH, Schoenfeld DA, Herndon DN, Tompkins RG,
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Caenorhabditis elegans pathways that surveil and defend mitochondria.

Liu Y, Samuel BS, Breen PC, Ruvkun G
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MUT-14 and SMUT-1 DEAD Box RNA Helicases Have Overlapping Roles in Germline RNAi and Endogenous siRNA Formation.

Phillips CM, Montgomery BE, Breen PC, Roovers EF, Rim YS, Ohsumi TK, Newman MA, van Wolfswinkel JC, Ketting RF, Ruvkun G, Montgomery TA
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Survival From Burns in the New Millennium: 70 Years' Experience From a Single Institution.

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Epitope-tagged protein-based artificial miRNA screens for optimized gene silencing in plants.

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Nat Protoc. 2014;9(4):939-49 - PMID: 24675734 - PMCID: PMC4208271

Genetic Polymorphisms in Metabolizing Enzymes Modifying the Association Between Smoking and Inflammatory Bowel Diseases.

Ananthakrishnan AN, Nguyen DD, Sauk J, Yajnik V, Xavier RJ
Inflamm Bowel Dis. 2014;20(5):783-9 - PMID: 24651583 - PMCID: PMC4113010

High-Throughput Screening for Novel Anti-Infectives Using a C. elegans Pathogenesis Model.

Conery AL, Larkins-Ford J, Ausubel FM, Kirienko NV
Curr Protoc Chem Biol. 2014;6(1):25-37 - PMID: 24652621 - PMCID: PMC4021578

The treatment-naive microbiome in new-onset Crohn's disease.

Gevers D, Kugathasan S, Denson LA, Vázquez-Baeza Y, Van Treuren W, Ren B, Schwager E, Knights D, Song SJ, Yassour M, Morgan XC, Kostic AD, Luo C, González A, McDonald D, Haberman Y, Walters T, Baker S, Rosh J, Stephens M, Heyman M, Markowitz J, Baldassano R, Griffiths A, Sylvester F, Mack D, Kim S, Crandall W, Hyams J, Huttenhower C, Knight R, Xavier RJ
Cell Host Microbe. 2014;15(3):382-92 - PMID: 24629344 - PMCID: PMC4059512

Progress Toward Synthetic Cells.

Blain JC, Szostak JW
Annu Rev Biochem. 2014;83:615-640 - PMID: 24606140

Membrane potential-dependent uptake of (18)F-triphenylphosphonium-a new voltage sensor as an imaging agent for detecting burn-induced apoptosis.

Zhao G, Yu YM, Shoup TM, Elmaleh DR, Bonab AA, Tompkins RG, Fischman AJ
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Enterococcus infection biology: Lessons from invertebrate host models.

Yuen GJ, Ausubel FM
J Microbiol. 2014;52(3):200-10 - PMID: 24585051 - PMCID: PMC4556283

Identification of Host-Targeted Small Molecules That Restrict Intracellular Mycobacterium tuberculosis Growth.

Stanley SA, Barczak AK, Silvis MR, Luo SS, Sogi K, Vokes M, Bray MA, Carpenter AE, Moore CB, Siddiqi N, Rubin EJ, Hung DT
PLoS Pathog. 2014;10(2):e1003946 - PMID: 24586159 - PMCID: PMC3930586

Human Genome-Wide RNAi Screen Identifies an Essential Role for Inositol Pyrophosphates in Type-I Interferon Response.

Pulloor NK, Nair S, Kostic AD, Bist P, Weaver JD, Riley AM, Tyagi R, Uchil PD, York JD, Snyder SH, García-Sastre A, Potter BV, Lin R, Shears SB, Xavier RJ, Krishnan MN
PLoS Pathog. 2014;10(2):e1003981 - PMID: 24586175 - PMCID: PMC3937324

Whole Animal Automated Platform for Drug Discovery against Multi-Drug Resistant Staphylococcus aureus.

Rajamuthiah R, Fuchs BB, Jayamani E, Kim Y, Larkins-Ford J, Conery A, Ausubel FM, Mylonakis E
PLoS One. 2014;9(2):e89189 - PMID: 24586584 - PMCID: PMC3929655

Rapid RNA Exchange in Aqueous Two-Phase System and Coacervate Droplets.

Jia TZ, Hentrich C, Szostak JW
Orig Life Evol Biosph. 2014;44(1):1-12 - PMID: 24577897 - PMCID: PMC4141154

The Microbiome in Inflammatory Bowel Diseases: Current Status and the Future Ahead.

Kostic AD, Xavier RJ, Gevers D
Gastroenterology. 2014;146(6):1489-99 - PMID: 24560869 - PMCID: PMC4034132

Long-term posttraumatic stress symptoms vary inversely with early opiate dosing in children recovering from serious burns: Effects durable at 4 years.

Sheridan RL, Stoddard FJ, Kazis LE, Lee A, Li NC, Kagan RJ, Palmieri TL, Meyer WJ, Nicolai M, Stubbs TK, Chan G, Hinson MI, Herndon DN, Tompkins RG,
J Trauma Acute Care Surg. 2014;76(3):828-832 - PMID: 24553556

IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans.

de Luca A, Smeekens SP, Casagrande A, Iannitti R, Conway KL, Gresnigt MS, Begun J, Plantinga TS, Joosten LA, van der Meer JW, Chamilos G, Netea MG, Xavier RJ, Dinarello CA, Romani L, van de Veerdonk FL
Proc Natl Acad Sci U S A. 2014;111(9):3526-31 - PMID: 24550444 - PMCID: PMC3948220

HDL redox activity is increased in HIV-infected men in association with macrophage activation and noncalcified coronary atherosclerotic plaque.

Zanni MV, Kelesidis T, Fitzgerald ML, Lo J, Abbara S, Wai B, Marmarelis E, Hernandez NJ, Yang OO, Currier JS, Grinspoon SK
Antivir Ther. 2014;19(8):805-11 - PMID: 24535655 - PMCID: PMC4423391

Structural insights into the effects of 2'-5' linkages on the RNA duplex.

Sheng J, Li L, Engelhart AE, Gan J, Wang J, Szostak JW
Proc Natl Acad Sci U S A. 2014;111(8):3050-5 - PMID: 24516151 - PMCID: PMC3939906

The Free Energy Landscape of Pseudorotation in 3'-5' and 2'-5' Linked Nucleic Acids.

Li L, Szostak JW
J Am Chem Soc. 2014;136(7):2858-65 - PMID: 24499340 - PMCID: PMC3982932

SMAD3 gene variant is a risk factor for recurrent surgery in patients with Crohn's disease.

Fowler SA, Ananthakrishnan AN, Gardet A, Stevens CR, Korzenik JR, Sands BE, Daly MJ, Xavier RJ, Yajnik V
J Crohns Colitis. 2014;8(8):845-51 - PMID: 24461721 - PMCID: PMC4237062

Autophagy is essential for cardiac morphogenesis during vertebrate development.

Lee E, Koo Y, Ng A, Wei Y, Luby-Phelps K, Juraszek A, Xavier RJ, Cleaver O, Levine B, Amatruda JF
Autophagy. 2014;10(4):572-87 - PMID: 24441423 - PMCID: PMC4091146

Synthesis and Non-Enzymatic Template-Directed Polymerization of 2'-Amino-2'-Deoxythreose Nucleotides.

Blain JC, Ricardo A, Szostak JW
J Am Chem Soc. 2014;136(5):2033-9 - PMID: 24409991 - PMCID: PMC4105081

Differential Effect of Genetic Burden on Disease Phenotypes in Crohn's Disease and Ulcerative Colitis: Analysis of a North American Cohort.

Ananthakrishnan AN, Huang H, Nguyen DD, Sauk J, Yajnik V, Xavier RJ
Am J Gastroenterol. 2014;109(3):395-400 - PMID: 24419484 - PMCID: PMC4225079

TOR Signaling Networks in Plant Growth and Metabolism.

Xiong Y, Sheen J
Plant Physiol. 2014;164(2):499-512 - PMID: 24385567 - PMCID: PMC3912084

Master Regulators in Plant Glucose Signaling Networks.

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The hybrid four-CBS-domain KIN?? subunit functions as the canonical ? subunit of the plant energy sensor SnRK1.

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Plant J. 2013;75(1):11-25 - PMID: 23551663

How antibiotics kill bacteria: new models needed?

Wright GD, Hung DT, Helmann JD
Nat Med. 2013;19(5):544-5 - PMID: 23652106

Moving beyond translation: glucose-TOR signaling in the transcriptional control of cell cycle.

Xiong Y, Sheen J
Cell Cycle. 2013;12(13):1989-90 - PMID: 23759578 - PMCID: PMC3737295

Novel Mechanism of Tumor Suppression by Polarity Gene Discs Large 1 (DLG1) Revealed in a Murine Model of Pediatric B-ALL.

Sandoval GJ, Graham DB, Gmyrek GB, Akilesh HM, Fujikawa K, Sammut B, Bhattacharya D, Srivatsan S, Kim A, Shaw AS, Yang-Iott K, Bassing CH, Duncavage E, Xavier RJ, Swat W
Cancer Immunol Res. 2013;1(6):426-37 - PMID: 24778134 - PMCID: PMC4006353

Virulence profile: Frederick M Ausubel.

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Bacterial toxins and small molecules elucidate endosomal trafficking.

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Trends Microbiol. 2013;22(2):53-5 - PMID: 24370463

Interactome maps of mouse gene regulatory domains reveal basic principles of transcriptional regulation.

Kieffer-Kwon KR, Tang Z, Mathe E, Qian J, Sung MH, Li G, Resch W, Baek S, Pruett N, Grøntved L, Vian L, Nelson S, Zare H, Hakim O, Reyon D, Yamane A, Nakahashi H, Kovalchuk AL, Zou J, Joung JK, Sartorelli V, Wei CL, Ruan X, Hager GL, Ruan Y, Casellas R
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Multiple small RNA pathways regulate the silencing of repeated and foreign genes in C. elegans.

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Ancient signals: comparative genomics of green plant CDPKs.

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Trends Plant Sci. 2013;19(2):79-89 - PMID: 24342084 - PMCID: PMC3932502

Correction of Crb1rd8 allele and retinal phenotype in C57BL/6N mice via TALEN-mediated homology-directed repair.

Low BE, Krebs MP, Joung JK, Tsai SQ, Nishina PM, Wiles MV
Invest Ophthalmol Vis Sci. 2013;55(1):387-395 - PMID: 24346171 - PMCID: PMC3921157

High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3.

De Nardo D, Labzin LI, Kono H, Seki R, Schmidt SV, Beyer M, Xu D, Zimmer S, Lahrmann C, Schildberg FA, Vogelhuber J, Kraut M, Ulas T, Kerksiek A, Krebs W, Bode N, Grebe A, Fitzgerald ML, Hernandez NJ, Williams BR, Knolle P, Kneilling M, Röcken M, Lütjohann D, Wright SD, Schultze JL, Latz E
Nat Immunol. 2013;15(2):152-60 - PMID: 24317040 - PMCID: PMC4009731

Endogenous ?-glucocerebrosidase activity in Abca12-/-epidermis elevates ceramide levels after topical lipid application but does not restore barrier function.

Haller JF, Cavallaro P, Hernandez NJ, Dolat L, Soscia SJ, Welti R, Grabowski GA, Fitzgerald ML, Freeman MW
J Lipid Res. 2013;55(3):493-503 - PMID: 24293640 - PMCID: PMC3934733

The cytokinin side chain commands shooting.

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Nonenzymatic template-directed RNA synthesis inside model protocells.

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Science. 2013;342(6162):1098-100 - PMID: 24288333 - PMCID: PMC4104020

Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia.

Liu Y, Shoji-Kawata S, Sumpter RM, Wei Y, Ginet V, Zhang L, Posner B, Tran KA, Green DR, Xavier RJ, Shaw SY, Clarke PG, Puyal J, Levine B
Proc Natl Acad Sci U S A. 2013;110(51):20364-71 - PMID: 24277826 - PMCID: PMC3870705

Deletion of the Murine Cytochrome P450 Cyp2j Locus by Fused BAC-Mediated Recombination Identifies a Role for Cyp2j in the Pulmonary Vascular Response to Hypoxia.

Zhou GL, Beloiartsev A, Yu B, Baron DM, Zhou W, Niedra R, Lu N, Tainsh LT, Zapol WM, Seed B, Bloch KD
PLoS Genet. 2013;9(11):e1003950 - PMID: 24278032 - PMCID: PMC3836722

Pathogen-Triggered Ethylene Signaling Mediates Systemic-Induced Susceptibility to Herbivory in Arabidopsis.

Groen SC, Whiteman NK, Bahrami AK, Wilczek AM, Cui J, Russell JA, Cibrian-Jaramillo A, Butler IA, Rana JD, Huang GH, Bush J, Ausubel FM, Pierce NE
Plant Cell. 2013;25(11):4755-66 - PMID: 24285796 - PMCID: PMC3875748

High-Resolution Mapping Reveals a Conserved, Widespread, Dynamic mRNA Methylation Program in Yeast Meiosis.

Schwartz S, Agarwala SD, Mumbach MR, Jovanovic M, Mertins P, Shishkin A, Tabach Y, Mikkelsen TS, Satija R, Ruvkun G, Carr SA, Lander ES, Fink GR, Regev A
Cell. 2013;155(6):1409-21 - PMID: 24269006 - PMCID: PMC3956118

Pseudomonas syringae Effector HopF2 Suppresses Arabidopsis Immunity by Targeting BAK1.

Zhou J, Wu S, Chen X, Liu C, Sheen J, Shan L, He P
Plant J. 2013;77(2):235-45 - PMID: 24237140 - PMCID: PMC4224013

Autophagy is redundant for the host defense against systemic Candida albicans infections.

Smeekens SP, Malireddi RK, Plantinga TS, Buffen K, Oosting M, Joosten LA, Kullberg BJ, Perfect JR, Scott WK, van de Veerdonk FL, Xavier RJ, van de Vosse E, Kanneganti TD, Johnson MD, Netea MG
Eur J Clin Microbiol Infect Dis. 2013;33(5):711-22 - PMID: 24202731

Genetic Regulation of Caenorhabditis elegans Lysosome Related Organelle Function.

Soukas AA, Carr CE, Ruvkun G
PLoS Genet. 2013;9(10):e1003908 - PMID: 24204312 - PMCID: PMC3812091

Long-Lasting Effects of BCG Vaccination on Both Heterologous Th1/Th17 Responses and Innate Trained Immunity.

Kleinnijenhuis J, Quintin J, Preijers F, Benn CS, Joosten LA, Jacobs C, van Loenhout J, Xavier RJ, Aaby P, van der Meer JW, van Crevel R, Netea MG
J Innate Immun. 2013;6(2):152-8 - PMID: 24192057 - PMCID: PMC3944069

Preparation of Fatty Acid or Phospholipid Vesicles by Thin-film Rehydration.

Zhu TF, Budin I, Szostak JW
Methods Enzymol. 2013;533:267-74 - PMID: 24182932 - PMCID: PMC4310237

Vesicle Extrusion Through Polycarbonate Track-etched Membranes using a Hand-held Mini-extruder.

Zhu TF, Budin I, Szostak JW
Methods Enzymol. 2013;533:275-82 - PMID: 24182933 - PMCID: PMC4310236

Preparation of Fatty Acid micelles.

Zhu TF, Budin I, Szostak JW
Methods Enzymol. 2013;533:283-8 - PMID: 24182934 - PMCID: PMC4310231

Selective Modulation of Autophagy, Innate Immunity, and Adaptive Immunity by Small Molecules.

Shaw SY, Tran K, Castoreno AB, Peloquin JM, Lassen KG, Khor B, Aldrich LN, Tan PH, Graham DB, Kuballa P, Goel G, Daly MJ, Shamji AF, Schreiber SL, Xavier RJ
ACS Chem Biol. 2013;8(12):2724-33 - PMID: 24168452 - PMCID: PMC3951132

mRNA display: from basic principles to macrocycle drug discovery.

Josephson K, Ricardo A, Szostak JW
Drug Discov Today. 2013;19(4):388-399 - PMID: 24157402

Reply to Cauwels et al.: Of men, not mice, and inflammation.

Warren HS, Tompkins RG, Mindrinos MN, Xiao W, Davis RW
Proc Natl Acad Sci U S A. 2013;110(34):E3151 - PMID: 24137663 - PMCID: PMC3752239

Reply to Osterburg et al.: To study human inflammatory diseases in humans.

Tompkins RG, Warren HS, Mindrinos MN, Xiao W, Davis RW
Proc Natl Acad Sci U S A. 2013;110(36):E3371 - PMID: 24137798 - PMCID: PMC3767510

Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins.

Maeder ML, Angstman JF, Richardson ME, Linder SJ, Cascio VM, Tsai SQ, Ho QH, Sander JD, Reyon D, Bernstein BE, Costello JF, Wilkinson MF, Joung JK
Nat Biotechnol. 2013;31(12):1137-42 - PMID: 24108092 - PMCID: PMC3858462

Autophagy at the crossroads of metabolism and cellular defense.

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Curr Opin Gastroenterol. 2013;29(6):588-596 - PMID: 24100719

Fast and accurate nonenzymatic copying of an RNA-like synthetic genetic polymer.

Zhang S, Blain JC, Zielinska D, Gryaznov SM, Szostak JW
Proc Natl Acad Sci U S A. 2013;110(44):17732-7 - PMID: 24101473 - PMCID: PMC3816440

Synthesis and structure-activity relationships of phenyl-substituted coumarins with anti-tubercular activity that target FadD32.

Kawate T, Iwase N, Shimizu M, Stanley SA, Wellington S, Kazyanskaya E, Hung DT
Bioorg Med Chem Lett. 2013;23(22):6052-9 - PMID: 24103299

A Small Volatile Bacterial Molecule Triggers Mitochondrial Dysfunction in Murine Skeletal Muscle.

Tzika AA, Constantinou C, Bandyopadhaya A, Psychogios N, Lee S, Mindrinos M, Martyn JA, Tompkins RG, Rahme LG
PLoS One. 2013;8(9):e74528 - PMID: 24098655 - PMCID: PMC3787027

Human disease locus discovery and mapping to molecular pathways through phylogenetic profiling.

Tabach Y, Golan T, Hernández-Hernández A, Messer AR, Fukuda T, Kouznetsova A, Liu JG, Lilienthal I, Levy C, Ruvkun G
Mol Syst Biol. 2013;9:692 - PMID: 24084807 - PMCID: PMC3817400

Genetic Variants Synthesize to Produce Paneth Cell Phenotypes that Define Subtypes of Crohn's Disease.

Vandussen KL, Liu TC, Li D, Towfic F, Modiano N, Winter R, Haritunians T, Taylor KD, Dhall D, Targan SR, Xavier RJ, McGovern DP, Stappenbeck TS
Gastroenterology. 2013;146(1):200-9 - PMID: 24076061 - PMCID: PMC3899786

Plant immune response to pathogens differs with changing temperatures.

Cheng C, Gao X, Feng B, Sheen J, Shan L, He P
Nat Commun. 2013;4:2530 - PMID: 24067909 - PMCID: PMC3901997

Deep Resequencing of GWAS Loci Identifies Rare Variants in CARD9, IL23R and RNF186 That Are Associated with Ulcerative Colitis.

Beaudoin M, Goyette P, Boucher G, Lo KS, Rivas MA, Stevens C, Alikashani A, Ladouceur M, Ellinghaus D, Törkvist L, Goel G, Lagacé C, Annese V, Bitton A, Begun J, Brant SR, Bresso F, Cho JH, Duerr RH, Halfvarson J, McGovern DP, Radford-Smith G, Schreiber S, Schumm PL, Sharma Y, Silverberg MS, Weersma RK, , , , D'Amato M, Vermeire S, Franke A, Lettre G, Xavier RJ, Daly MJ, Rioux JD
PLoS Genet. 2013;9(9):e1003723 - PMID: 24068945 - PMCID: PMC3772057

Dual Regulation of the lin-14 Target mRNA by the lin-4 miRNA.

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PLoS One. 2013;8(9):e75475 - PMID: 24058689 - PMCID: PMC3772890

Advances in inflammatory bowel disease pathogenesis: linking host genetics and the microbiome.

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Gut. 2013;62(10):1505-10 - PMID: 24037875 - PMCID: PMC3822528

Axl mediates acquired resistance of head and neck cancer cells to the epidermal growth factor receptor inhibitor erlotinib.

Giles KM, Kalinowski FC, Candy PA, Epis MR, Zhang PM, Redfern AD, Stuart LM, Goodall GJ, Leedman PJ
Mol Cancer Ther. 2013;12(11):2541-58 - PMID: 24026012

Locus-specific editing of histone modifications at endogenous enhancers.

Mendenhall EM, Williamson KE, Reyon D, Zou JY, Ram O, Joung JK, Bernstein BE
Nat Biotechnol. 2013;31(12):1133-6 - PMID: 24013198 - PMCID: PMC3858395

Targeted Deletion and Inversion of Tandemly Arrayed Genes in Arabidopsis thaliana Using Zinc Finger Nucleases.

Qi Y, Li X, Zhang Y, Starker CG, Baltes NJ, Zhang F, Sander JD, Reyon D, Joung JK, Voytas DF
G3 (Bethesda). 2013;3(10):1707-1715 - PMID: 23979943 - PMCID: PMC3789795

Atg16l1 is Required for Autophagy in Intestinal Epithelial Cells and Protection of Mice from Salmonella Infection.

Conway KL, Kuballa P, Song JH, Patel KK, Castoreno AB, Yilmaz OH, Jijon HB, Zhang M, Aldrich LN, Villablanca EJ, Peloquin JM, Goel G, Lee IA, Mizoguchi E, Shi HN, Bhan AK, Shaw SY, Schreiber SL, Virgin HW, Shamji AF, Stappenbeck TS, Reinecker HC, Xavier RJ
Gastroenterology. 2013;145(6):1347-57 - PMID: 23973919 - PMCID: PMC3840157

Differences in Resuscitation in Morbidly Obese Burn Patients May Contribute to High Mortality.

Rae L, Pham TN, Carrougher G, Honari S, Gibran NS, Arnoldo BD, Gamelli RL, Tompkins RG, Herndon DN
J Burn Care Res. 2013;34(5):507-14 - PMID: 23966116 - PMCID: PMC3800202

Out of Context: Clinical Practice Guidelines and Patients With Multiple Chronic Conditions: A Systematic Review.

Wyatt KD, Stuart LM, Brito JP, Carranza Leon B, Domecq JP, Prutsky GJ, Egginton JS, Calvin AD, Shah ND, Murad MH, Montori VM
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Beclin 2 Functions in Autophagy, Degradation of G Protein-Coupled Receptors, and Metabolism.

He C, Wei Y, Sun K, Li B, Dong X, Zou Z, Liu Y, Kinch LN, Khan S, Sinha S, Xavier RJ, Grishin NV, Xiao G, Eskelinen EL, Scherer PE, Whistler JL, Levine B
Cell. 2013;154(5):1085-99 - PMID: 23954414 - PMCID: PMC4231430

In silico abstraction of zinc finger nuclease cleavage profiles reveals an expanded landscape of off-target sites.

Sander JD, Ramirez CL, Linder SJ, Pattanayak V, Shoresh N, Ku M, Foden JA, Reyon D, Bernstein BE, Liu DR, Joung JK
Nucleic Acids Res. 2013;41(19):e181 - PMID: 23945932 - PMCID: PMC3799455

Dislodgement of port-A catheters in pediatric oncology patients: 11 years of experience.

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Identification of novel inhibitors of non-replicating M. tuberculosis using a carbon starvation model.

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Mild Obesity Is Protective After Severe Burn Injury.

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Heritable and Precise Zebrafish Genome Editing Using a CRISPR-Cas System.

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Genetic risk factors for Clostridium difficile infection in ulcerative colitis.

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Natural selection in a bangladeshi population from the cholera-endemic ganges river delta.

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Engineering Customized TALE Nucleases (TALENs) and TALE Transcription Factors by Fast Ligation-Based Automatable Solid-Phase High-Throughput (FLASH) Assembly.

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CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation.

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Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32.

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High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells.

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Skin Microbiome Imbalance in Patients with STAT1/STAT3 Defects Impairs Innate Host Defense Responses.

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Competition between model protocells driven by an encapsulated catalyst.

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Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis.

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Card9 Mediates Intestinal Epithelial Cell Restitution, T-helper 17 Responses, and Control of Bacterial Infection in Mice.

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A cytoprotective perspective on longevity regulation.

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Conformational stability, vibrational spectra, HOMO-LUMO and NBO analysis of 1,3,4-thiadiazolidine-2,5-dithione with experimental (FT-IR and FT-Raman) techniques and scaled quantum mechanical calculations.

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CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells.

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RhoGTPases - NODes for effector-triggered immunity in animals.

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Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function.

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How Does Genotype Influence Disease Phenotype in Inflammatory Bowel Disease?

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Comprehensive Protein-Based Artificial MicroRNA Screens for Effective Gene Silencing in Plants.

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Cutting Edge: cell-autonomous control of IL-7 response revealed in a novel stage of precursor B cells.

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Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection.

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Concomitant BRAF and PI3K/mTOR Blockade Is Required for Effective Treatment of BRAFV600E Colorectal Cancer.

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Trauma-associated Human Neutrophil Alterations Revealed by Comparative Proteomics Profiling.

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Efficacy of Phosphodiesterase 5 inhibitor on distant burn-induced muscle autophagy, microcirculation and survival rate.

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Evaluation of Intragastric Vs Intraperitoneal Glucose Tolerance Tests in the Evaluation of Insulin Resistance in a Rodent Model of Burn Injury and Glucagon-Like Polypeptide-1 Treatment.

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Benchmarks for Multidimensional Recovery After Burn Injury in Young Adults: The Development, Validation, and Testing of the American Burn Association/Shriners Hospitals for Children Young Adult Burn Outcome Questionnaire.

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Determination of Burn Patient Outcome by Large-Scale Quantitative Discovery Proteomics.

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Mitochondria-targeted antioxidant promotes recovery of skeletal muscle mitochondrial function after burn trauma assessed by in vivo 31P nuclear magnetic resonance and electron paramagnetic resonance spectroscopy.

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Synthesis of N3'-P5'-linked phosphoramidate DNA by nonenzymatic template-directed primer extension.

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Functional RNAs exhibit tolerance for non-heritable 2'-5' versus 3'-5' backbone heterogeneity.

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Dectin-1 activation controls maturation of ?-1,3-glucan-containing phagosomes.

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Glucose-TOR signalling reprograms the transcriptome and activates meristems.

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MicroRNAs Visit the ER.

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DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity.

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MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability.

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Pseudomonas aeruginosa Disrupts Caenorhabditis elegans Iron Homeostasis, Causing a Hypoxic Response and Death.

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TALEN-based Gene Correction for Epidermolysis Bullosa.

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Persistent bacterial infections, antibiotic tolerance, and the oxidative stress response.

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Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis.

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Pseudomonas aeruginosa Disrupts Caenorhabditis elegans Iron Homeostasis, Causing a Hypoxic Response and Death.

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Trehalose biosynthesis promotes Pseudomonas aeruginosa pathogenicity in plants.

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Succinate is an inflammatory signal that induces IL-1? through HIF-1?.

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Genome-wide Analysis of Immune System Genes by Expressed Sequence Tag Profiling.

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From genetics of inflammatory bowel disease towards mechanistic insights.

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Polarity gene discs large homolog 1 regulates the generation of memory T cells.

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Resolvin D2 restores neutrophil directionality and improves survival after burns.

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Identification of a candidate therapeutic autophagy-inducing peptide.

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Angiotensin II Drives the Production of Tumor-Promoting Macrophages.

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Effector-triggered versus pattern-triggered immunity: how animals sense pathogens.

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Development of a Colon Cancer GEMM-Derived Orthotopic Transplant Model for Drug Discovery and Validation.

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Genomic responses in mouse models poorly mimic human inflammatory diseases.

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Mutations causing medullary cystic kidney disease type 1 lie in a large VNTR in MUC1 missed by massively parallel sequencing.

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Robust, synergistic regulation of human gene expression using TALE activators.

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Phosphorylation of D-allose by hexokinase involved in regulation of OsABF1 expression for growth inhibition in Oryza sativa L.

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?-6 Polyunsaturated fatty acids extend life span through the activation of autophagy.

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Burn injury-induced IRS-1 degradation in mouse skeletal muscle.

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Development of a Genomic Metric That Can Be Rapidly Used to Predict Clinical Outcome in Severely Injured Trauma Patients.

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Bifurcation of Arabidopsis NLR Immune Signaling via Ca(2+)-Dependent Protein Kinases.

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Autophagy modulates Borrelia burgdorferi-induced production of interleukin-1? (IL-1?).

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Translating the Genomics Revolution: The Need for an International Gene Therapy Consortium for Monogenic Diseases.

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High-throughput sequencing reveals extraordinary fluidity of miRNA, piRNA, and siRNA pathways in nematodes.

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Efficient genome editing in zebrafish using a CRISPR-Cas system.

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Identification of Novel Host-Targeted Compounds That Protect From Anthrax Lethal Toxin-Induced Cell Death.

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Radiation resistance of biological reagents for in situ life detection.

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ATG5 regulates plasma cell differentiation.

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Nitric oxide activates intradomain disulfide bond formation in the kinase loop of Akt1/PKB? after burn injury.

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Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans.

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Identification of Pseudomonas aeruginosa Phenazines that Kill Caenorhabditis elegans.

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Imaging C-Fos Gene Expression in Burns Using Lipid Coated Spion Nanoparticles.

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Multicomponent assembly of proposed DNA precursors in water.

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Concentration-driven growth of model protocell membranes.

Budin I, Debnath A, Szostak JW
J Am Chem Soc. 2012;134(51):20812-9 - PMID: 23198690 - PMCID: PMC3530389

Enhanced Tim3 activity improves survival after influenza infection.

Cho JL, Roche MI, Sandall B, Brass AL, Seed B, Xavier RJ, Medoff BD
J Immunol. 2012;189(6):2879-89 - PMID: 22875804 - PMCID: PMC3436990

A high-content imaging workflow to study Grb2 signaling complexes by expression cloning.

Freeman J, Kriston-Vizi J, Seed B, Ketteler R
J Vis Exp. 2012;(68):ePub - PMID: 23150065 - PMCID: PMC3499067

Reply to Guy et al.: Support for a bottleneck in the 2011 Escherichia coli O104:H4 outbreak in Germany.

Grad YH, Lipsitch M, Griggs AD, Haas BJ, Shea TP, McCowan C, Montmayeur A, FitzGerald M, Wortman JR, Krogfelt KA, Bingen E, Weill FX, Tietze E, Flieger A, Lander ES, Nusbaum C, Birren BW, Hung DT, Hanage WP
Proc Natl Acad Sci U S A. 2012;109(52):E3629-30 - PMID: 23479789 - PMCID: PMC3535640

Identification of small RNA pathway genes using patterns of phylogenetic conservation and divergence.

Tabach Y, Billi AC, Hayes GD, Newman MA, Zuk O, Gabel H, Kamath R, Yacoby K, Chapman B, Garcia SM, Borowsky M, Kim JK, Ruvkun G
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Simvastatin Protects Hepatocytes From Apoptosis by Suppressing the TNF-?/Caspase-3 Signaling Pathway in Mice With Burn Injury.

Zhao G, Yu YM, Kaneki M, Tompkins RG, Fischman AJ
Ann Surg. 2012;257(6):1129-36 - PMID: 23275311 - PMCID: PMC4102342

Synthesis of N3´-P5´-Phosphoramidate DNA by Non-enzymatic Template-directed Primer Extension.

Zhang S, Zhang N, Blain JC, Szostak JW
J Am Chem Soc. 2012;135(2):924-32 - PMID: 23252395 - PMCID: PMC3548433

The LRR and RING Domain Protein LRSAM1 Is an E3 Ligase Crucial for Ubiquitin-Dependent Autophagy of Intracellular Salmonella Typhimurium.

Huett A, Heath RJ, Begun J, Sassi SO, Baxt LA, Vyas JM, Goldberg MB, Xavier RJ
Cell Host Microbe. 2012;12(6):778-90 - PMID: 23245322 - PMCID: PMC3785244

Concentration-driven growth of model protocell membranes.

Budin I, Debnath A, Szostak JW
J Am Chem Soc. 2012;134(51):20812-9 - PMID: 23198690 - PMCID: PMC3530389

Stem Cell Signaling in Immunity and Development.

Lee H, Chah OK, Plotnikov J, Sheen J
Cold Spring Harb Symp Quant Biol. 2012;77:75-81 - PMID: 23174766

TALENs: a widely applicable technology for targeted genome editing.

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Nat Rev Mol Cell Biol. 2012;14(1):49-55 - PMID: 23169466 - PMCID: PMC3547402

Brown Adipose Tissue and Its Modulation by a Mitochondria-targeted Peptide in Rat Burn Injury Induced Hypermetabolism.

Yo K, Yu YM, Zhao G, Bonab AA, Aikawa N, Tompkins RG, Fischman AJ
Am J Physiol Endocrinol Metab. 2012;304(4):E331-41 - PMID: 23169784 - PMCID: PMC3566510

A High-content Imaging Workflow to Study Grb2 Signaling Complexes by Expression Cloning.

Freeman J, Kriston-Vizi J, Seed B, Ketteler R
J Vis Exp. 2012;(68):ePub - PMID: 23150065 - PMCID: PMC3499067

Combination of Radiation and Burn Injury Alters [18F] 2-Fluoro-2-Deoxy-D-Glucose Uptake in Mice.

Carter EA, Winter D, Tolman C, Paul K, Hamrahi V, Tompkins RG, Fischman AJ
J Burn Care Res. 2012;33(6):723-30 - PMID: 23143615 - PMCID: PMC3673011

Prediction of C. elegans Longevity Genes by Human and Worm Longevity Networks.

Tacutu R, Shore DE, Budovsky A, de Magalhães JP, Ruvkun G, Fraifeld VE, Curran SP
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Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.

Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP, Hui KY, Lee JC, Schumm LP, Sharma Y, Anderson CA, Essers J, Mitrovic M, Ning K, Cleynen I, Theatre E, Spain SL, Raychaudhuri S, Goyette P, Wei Z, Abraham C, Achkar JP, Ahmad T, Amininejad L, Ananthakrishnan AN, Andersen V, Andrews JM, Baidoo L, Balschun T, Bampton PA, Bitton A, Boucher G, Brand S, Büning C, Cohain A, Cichon S, D'Amato M, De Jong D, Devaney KL, Dubinsky M, Edwards C, Ellinghaus D, Ferguson LR, Franchimont D, Fransen K, Ge ...
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Measurement of Phagocytosis, Phagosome Acidification, and Intracellular Killing of Staphylococcus aureus.

Sokolovska A, Becker CE, Stuart LM
Curr Protoc Immunol. 2012;Chapter 14:Unit14.30 - PMID: 23129153

Essential cell autonomous role for interferon regulatory factor 1 in interferon-?-mediated inhibition of norovirus replication in macrophages.

Maloney NS, Thackray LB, Goel G, Hwang S, Duan E, Vachharajani P, Xavier R, Virgin HW
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Gardet A, Xavier RJ
Curr Opin Immunol. 2012;24(5):522-9 - PMID: 23041451

Engineering Designer Transcription Activator--Like Effector Nucleases (TALENs) by REAL or REAL-Fast Assembly.

Reyon D, Khayter C, Regan MR, Joung JK, Sander JD
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Clinical review. Comparative effectiveness of drug treatments to prevent fragility fractures: a systematic review and network meta-analysis.

Murad MH, Drake MT, Mullan RJ, Mauck KF, Stuart LM, Lane MA, Abu Elnour NO, Erwin PJ, Hazem A, Puhan MA, Li T, Montori VM
J Clin Endocrinol Metab. 2012;97(6):1871-80 - PMID: 22466336

Clinical review. Risk factors for low bone mass-related fractures in men: a systematic review and meta-analysis.

Drake MT, Murad MH, Mauck KF, Lane MA, Undavalli C, Elraiyah T, Stuart LM, Prasad C, Shahrour A, Mullan RJ, Hazem A, Erwin PJ, Montori VM
J Clin Endocrinol Metab. 2012;97(6):1861-70 - PMID: 22466344

The Two-Component Sensor KinB Acts as a Phosphatase to Regulate Pseudomonas aeruginosa Virulence.

Chand NS, Clatworthy AE, Hung DT
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Safety and dosing of bevacizumab (avastin) for the treatment of recurrent respiratory papillomatosis.

Best SR, Friedman AD, Landau-Zemer T, Barbu AM, Burns JA, Freeman MW, Halvorsen YD, Hillman RE, Zeitels SM
Ann Otol Rhinol Laryngol. 2012;121(9):587-93 - PMID: 23012897

Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment.

Morgan XC, Tickle TL, Sokol H, Gevers D, Devaney KL, Ward DV, Reyes JA, Shah SA, Leleiko N, Snapper SB, Bousvaros A, Korzenik J, Sands BE, Xavier RJ, Huttenhower C
Genome Biol. 2012;13(9):R79 - PMID: 23013615 - PMCID: PMC3506950

Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes.

Kleinnijenhuis J, Quintin J, Preijers F, Joosten LA, Ifrim DC, Saeed S, Jacobs C, van Loenhout J, de Jong D, Stunnenberg HG, Xavier RJ, van der Meer JW, van Crevel R, Netea MG
Proc Natl Acad Sci U S A. 2012;109(43):17537-42 - PMID: 22988082 - PMCID: PMC3491454

CDPKs in immune and stress signaling.

Boudsocq M, Sheen J
Trends Plant Sci. 2012;18(1):30-40 - PMID: 22974587 - PMCID: PMC3534830

Evaluation of OPEN Zinc Finger Nucleases for Direct Gene Targeting of the ROSA26 Locus in Mouse Embryos.

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Guidelines for the use and interpretation of assays for monitoring autophagy.

Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai ...
Autophagy. 2012;8(4):445-544 - PMID: 22966490 - PMCID: PMC3404883

Previous burn injury predisposes mice to lipopolysaccharide-induced changes in glucose metabolism.

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J Burn Care Res. 2012;33(5):683-9 - PMID: 22961012 - PMCID: PMC3441057

The American Burn Association/Shriners Hospitals for Children Burn Outcomes Program: A progress report at 15 years.

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J Trauma Acute Care Surg. 2012;73(3 Suppl 2):S173-8 - PMID: 22929544

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J Trauma Acute Care Surg. 2012;73(3 Suppl 2):S197-204 - PMID: 22929547

Measuring the cost of care for children with acute burn injury.

Carey K, Kazis LE, Lee AF, Liang MH, Li NC, Hinson MI, Lydon MK, Bauk H, Shapiro GD, Tompkins RG,
J Trauma Acute Care Surg. 2012;73(3 Suppl 2):S229-33 - PMID: 22929551

FLS2-Mediated Responses to Ax21-Derived Peptides: Response to the Mueller et al. Commentary.

Danna CH, Zhang XC, Khatri A, Bent AF, Ronald PC, Ausubel FM
Plant Cell. 2012;24(8):3174-6 - PMID: 22923675 - PMCID: PMC3462622

Complexity in Differential Peptide-Receptor Signaling: Response to Segonzac et al. and Mueller et al. Commentaries.

Lee H, Khatri A, Plotnikov JM, Zhang XC, Sheen J
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p40phox Expression Regulates Neutrophil Recruitment and Function during the Resolution Phase of Intestinal Inflammation.

Conway KL, Goel G, Sokol H, Manocha M, Mizoguchi E, Terhorst C, Bhan AK, Gardet A, Xavier RJ
J Immunol. 2012;189(7):3631-40 - PMID: 22914050 - PMCID: PMC3780969

Genome-Wide Identification of Pseudomonas aeruginosa Virulence-Related Genes Using a Caenorhabditis elegans Infection Model.

Feinbaum RL, Urbach JM, Liberati NT, Djonovic S, Adonizio A, Carvunis AR, Ausubel FM
PLoS Pathog. 2012;8(7):e1002813 - PMID: 22911607 - PMCID: PMC3406104

Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes.

Quintin J, Saeed S, Martens JH, Giamarellos-Bourboulis EJ, Ifrim DC, Logie C, Jacobs L, Jansen T, Kullberg BJ, Wijmenga C, Joosten LA, Xavier RJ, van der Meer JW, Stunnenberg HG, Netea MG
Cell Host Microbe. 2012;12(2):223-32 - PMID: 22901542 - PMCID: PMC3864037

Gram-Negative Bacterial Infection in Thigh Abscess Can Migrate to Distant Burn Depending on Burn Depth.

Hamrahi V, Hamblin MR, Jung W, Benjamin JB, Paul KW, Fischman AJ, Tompkins RG, Carter EA
Interdiscip Perspect Infect Dis. 2012;2012:567140 - PMID: 22899912 - PMCID: PMC3412104

Enhanced Tim3 Activity Improves Survival after Influenza Infection.

Cho JL, Roche MI, Sandall B, Brass AL, Seed B, Xavier RJ, Medoff BD
J Immunol. 2012;189(6):2879-89 - PMID: 22875804 - PMCID: PMC3436990

A synthetic biology framework for programming eukaryotic transcription functions.

Khalil AS, Lu TK, Bashor CJ, Ramirez CL, Pyenson NC, Joung JK, Collins JJ
Cell. 2012;150(3):647-58 - PMID: 22863014 - PMCID: PMC3653585

New insights into siRNA amplification and RNAi.

Zhang C, Ruvkun G
RNA Biol. 2012;9(8):1045-9 - PMID: 22858672 - PMCID: PMC3551858

An interview with Jen Sheen.

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Trends Plant Sci. 2012;17(6):321-2 - PMID: 22860262

Multicomponent assembly of proposed DNA precursors in water.

Powner MW, Zheng SL, Szostak JW
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Case 23-2012.

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Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways.

Shore DE, Carr CE, Ruvkun G
PLoS Genet. 2012;8(7):e1002792 - PMID: 22829775 - PMCID: PMC3400582

TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria.

Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
Cell. 2012;150(3):606-19 - PMID: 22819539 - PMCID: PMC3660860

Genes Involved in the Evolution of Herbivory By A Leaf-Mining, Drosophilid Fly.

Whiteman NK, Gloss AD, Sackton TB, Groen SC, Humphrey PT, Lapoint RT, Sønderby IE, Halkier BA, Kocks C, Ausubel FM, Pierce NE
Genome Biol Evol. 2012;4(9):900-16 - PMID: 22813779 - PMCID: PMC3516228

EGL-9 Controls C. elegans Host Defense Specificity through Prolyl Hydroxylation-Dependent and -Independent HIF-1 Pathways.

Luhachack LG, Visvikis O, Wollenberg AC, Lacy-Hulbert A, Stuart LM, Irazoqui JE
PLoS Pathog. 2012;8(7):e1002798 - PMID: 22792069 - PMCID: PMC3390412

Eradication of bacterial persisters with antibiotic-generated hydroxyl radicals.

Schmidt Grant S, Kaufmann BB, Chand NS, Haseley N, Hung DT
Proc Natl Acad Sci U S A. 2012;109(30):12147-52 - PMID: 22778419 - PMCID: PMC3409745

Non-invasive mapping of the gastrointestinal microbiota identifies children with inflammatory bowel disease.

Papa E, Docktor M, Smillie C, Weber S, Preheim SP, Gevers D, Giannoukos G, Ciulla D, Tabbaa D, Ingram J, Schauer DB, Ward DV, Korzenik JR, Xavier RJ, Bousvaros A, Alm EJ
PLoS One. 2012;7(6):e39242 - PMID: 22768065 - PMCID: PMC3387146

Helminth Infection Impairs Autophagy-Mediated Killing of Bacterial Enteropathogens by Macrophages.

Su CW, Cao Y, Zhang M, Kaplan J, Su L, Fu Y, Walker WA, Xavier R, Cherayil BJ, Shi HN
J Immunol. 2012;189(3):1459-66 - PMID: 22732589 - PMCID: PMC3423331

Perception of volatiles produced by UVC-irradiated plants alters the response to viral infection in naïve neighboring plants.

Yao Y, Danna CH, Ausubel FM, Kovalchuk I
Plant Signal Behav. 2012;7(7):741-5 - PMID: 22751319 - PMCID: PMC3583953

Stimulation of Host Immune Defenses by a Small Molecule Protects C. elegans from Bacterial Infection.

Pukkila-Worley R, Feinbaum R, Kirienko NV, Larkins-Ford J, Conery AL, Ausubel FM
PLoS Genet. 2012;8(6):e1002733 - PMID: 22719261 - PMCID: PMC3375230

MUT-16 promotes formation of perinuclear Mutator foci required for RNA silencing in the C. elegans germline.

Phillips CM, Montgomery TA, Breen PC, Ruvkun G
Genes Dev. 2012;26(13):1433-44 - PMID: 22713602 - PMCID: PMC3403012

Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENs.

Cade L, Reyon D, Hwang WY, Tsai SQ, Patel S, Khayter C, Joung JK, Sander JD, Peterson RT, Yeh JR
Nucleic Acids Res. 2012;40(16):8001-10 - PMID: 22684503 - PMCID: PMC3439908

Photochemically driven redox chemistry induces protocell membrane pearling and division.

Zhu TF, Adamala K, Zhang N, Szostak JW
Proc Natl Acad Sci U S A. 2012;109(25):9828-32 - PMID: 22665773 - PMCID: PMC3382484

Improved Somatic Mutagenesis in Zebrafish Using Transcription Activator-Like Effector Nucleases (TALENs).

Moore FE, Reyon D, Sander JD, Martinez SA, Blackburn JS, Khayter C, Ramirez CL, Joung JK, Langenau DM
PLoS One. 2012;7(5):e37877 - PMID: 22655075 - PMCID: PMC3360007

Cytokinin signaling networks

Hwang I., Sheen J., Mueller B.
Annu Rev Plant Biology. . 2012;63:353-380

Penetration Resistance: PKR's Other Talent.

Lacy-Hulbert A, Stuart LM
Immunity. 2012;36(5):695-6 - PMID: 22633454

Tribbles 2 (Trib2) is a novel regulator of toll-like receptor 5 signaling.

Wei SC, Rosenberg IM, Cao Z, Huett AS, Xavier RJ, Podolsky DK
Inflamm Bowel Dis. 2012;18(5):877-88 - PMID: 22271508 - PMCID: PMC3881418

Nondegradative Role of Atg5-Atg12/ Atg16L1 Autophagy Protein Complex in Antiviral Activity of Interferon Gamma.

Hwang S, Maloney NS, Bruinsma MW, Goel G, Duan E, Zhang L, Shrestha B, Diamond MS, Dani A, Sosnovtsev SV, Green KY, Lopez-Otin C, Xavier RJ, Thackray LB, Virgin HW
Cell Host Microbe. 2012;11(4):397-409 - PMID: 22520467 - PMCID: PMC3348177

Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening.

Stanley SA, Schmidt Grant S, Kawate T, Iwase N, Shimizu M, Wivagg C, Silvis M, Kazyanskaya E, Aquadro J, Golas A, Fitzgerald M, Dai H, Zhang L, Hung DT
ACS Chem Biol. 2012;7(8):1377-84 - PMID: 22577943 - PMCID: PMC3560293

Transient expression assays for quantifying signaling output.

Niu Y, Sheen J
Methods Mol Biol. 2012;876:195-206 - PMID: 22576097

DNA purification from multiple sources in plant research with homemade silica resins.

Li JF, Sheen J
Methods Mol Biol. 2012;862:53-9 - PMID: 22419488

Targeted parallel sequencing of large genetically-defined genomic regions for identifying mutations in Arabidopsis.

Liu KH, McCormack M, Sheen J
Plant Methods. 2012;8(1):12 - PMID: 22462410 - PMCID: PMC3348062

In vitro selection of functional lantipeptides.

Hofmann FT, Szostak JW, Seebeck FP
J Am Chem Soc. 2012;134(19):8038-41 - PMID: 22545861 - PMCID: PMC3353655

Regulation of monocyte functional heterogeneity by miR-146a and Relb.

Etzrodt M, Cortez-Retamozo V, Newton A, Zhao J, Ng A, Wildgruber M, Romero P, Wurdinger T, Xavier R, Geissmann F, Meylan E, Nahrendorf M, Swirski FK, Baltimore D, Weissleder R, Pittet MJ
Cell Rep. 2012;1(4):317-324 - PMID: 22545247 - PMCID: PMC3334310

The Caenorhabditis elegans RDE-10/RDE-11 Complex Regulates RNAi by Promoting Secondary siRNA Amplification.

Zhang C, Montgomery TA, Fischer SE, Garcia SM, Riedel CG, Fahlgren N, Sullivan CM, Carrington JC, Ruvkun G
Curr Biol. 2012;22(10):881-90 - PMID: 22542102 - PMCID: PMC3371361

In vivo molecular imaging of murine embryonic stem cells delivered to a burn wound surface via Integra® scaffolding.

Hamrahi VF, Goverman J, Jung W, Wu JC, Fischman AJ, Tompkins RG, Yu YY, Fagan SP, Carter EA
J Burn Care Res. 2012;33(2):e49-54 - PMID: 22540138 - PMCID: PMC3311992

PIWI Associated siRNAs and piRNAs Specifically Require the Caenorhabditis elegans HEN1 Ortholog henn-1.

Montgomery TA, Rim YS, Zhang C, Dowen RH, Phillips CM, Fischer SE, Ruvkun G
PLoS Genet. 2012;8(4):e1002616 - PMID: 22536158 - PMCID: PMC3334881

Host Translational Inhibition by Pseudomonas aeruginosa Exotoxin A Triggers an Immune Response in Caenorhabditis elegans.

McEwan DL, Kirienko NV, Ausubel FM
Cell Host Microbe. 2012;11(4):364-74 - PMID: 22520464 - PMCID: PMC3334877

An image analysis toolbox for high-throughput C. elegans assays.

Wählby C, Kamentsky L, Liu ZH, Riklin-Raviv T, Conery AL, O'Rourke EJ, Sokolnicki KL, Visvikis O, Ljosa V, Irazoqui JE, Golland P, Ruvkun G, Ausubel FM, Carpenter AE
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Establishment and characterization of a novel chordoma cell line: CH22.

Liu X, Nielsen GP, Rosenberg AE, Waterman PR, Yang W, Choy E, Sassi S, Yang S, Harmon DC, Yang C, Schwab JH, Kobayashi E, Mankin HJ, Xavier R, Weissleder R, Duan Z, Hornicek FJ
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Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses.

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FLASH assembly of TALENs for high-throughput genome editing.

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The changing pattern and implications of multiple organ failure after blunt injury with hemorrhagic shock*

Minei JP, Cuschieri J, Sperry J, Moore EE, West MA, Harbrecht BG, O'Keefe GE, Cohen MJ, Moldawer LL, Tompkins RG, Maier RV
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Attempts to define life do not help to understand the origin of life.

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J Biomol Struct Dyn. 2012;29(4):599-600 - PMID: 22208251 - PMCID: PMC4208307

Incidence of Catheter-Associated Bloodstream Infection After Introduction of Minocycline and Rifampin Antimicrobial-Coated Catheters in a Pediatric Burn Population.

Weber JM, Sheridan RL, Fagan S, Ryan CM, Pasternack MS, Tompkins RG
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The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques.

van Gils JM, Derby MC, Fernandes LR, Ramkhelawon B, Ray TD, Rayner KJ, Parathath S, Distel E, Feig JL, Alvarez-Leite JI, Rayner AJ, McDonald TO, O'Brien KD, Stuart LM, Fisher EA, Lacy-Hulbert A, Moore KJ
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Immune defense mechanisms in the Caenorhabditis elegans intestinal epithelium.

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Severe injury is associated with insulin resistance, endoplasmic reticulum stress response, and unfolded protein response.

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The apoplastic oxidative burst peroxidase in Arabidopsis is a major component of pattern-triggered immunity.

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HIV-1 Nef mobilizes lipid rafts in macrophages through a pathway that competes with ABCA1-dependent cholesterol efflux.

Cui HL, Grant A, Mukhamedova N, Pushkarsky T, Jennelle L, Dubrovsky L, Gaus K, Fitzgerald ML, Sviridov D, Bukrinsky M
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Thermal Injury Activates eEF2k-Dependent eEF2 Pathway in Pediatric Patients.

Song J, Finnerty CC, Herndon DN, Kraft R, Boehning D, Brooks NC, Tompkins RG, Jeschke MG
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Activated ribonucleotides undergo a sugar pucker switch upon binding to a single-stranded RNA template.

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J Am Chem Soc. 2012;134(8):3691-4 - PMID: 22296305 - PMCID: PMC3448298

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Genome-wide siRNA screen for mediators of NF-?B activation.

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Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease.

Rivas MA, Beaudoin M, Gardet A, Stevens C, Sharma Y, Zhang CK, Boucher G, Ripke S, Ellinghaus D, Burtt N, Fennell T, Kirby A, Latiano A, Goyette P, Green T, Halfvarson J, Haritunians T, Korn JM, Kuruvilla F, Lagacé C, Neale B, Lo KS, Schumm P, Törkvist L, , , , Dubinsky MC, Brant SR, Silverberg MS, Duerr RH, Altshuler D, Gabriel S, Lettre G, Franke A, D'Amato M, McGovern DP, Cho JH, Rioux JD, Xavier RJ, Daly MJ
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Engineering designer nucleases with customized cleavage specificities.

Sander JD, Maeder ML, Joung JK
Curr Protoc Mol Biol. 2011;Chapter 12:Unit12.13 - PMID: 21987054 - PMCID: PMC3379964

automated DNA sequencing technology.

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Curr Protoc Mol Biol. 2011;Chapter 7:Unit7.2 - PMID: 21987057

Pseudomonas aeruginosa RhlR is required to neutralize the cellular immune response in a Drosophila melanogaster oral infection model.

Limmer S, Haller S, Drenkard E, Lee J, Yu S, Kocks C, Ausubel FM, Ferrandon D
Proc Natl Acad Sci U S A. 2011;108(42):17378-83 - PMID: 21987808 - PMCID: PMC3198323

Regulation of the C. elegans molt by pqn-47.

Russel S, Frand AR, Ruvkun G
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Genome-wide expression profiling implicates a MAST3-regulated gene set in colonic mucosal inflammation of ulcerative colitis patients.

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Inflamm Bowel Dis. 2011;18(6):1072-80 - PMID: 21994190 - PMCID: PMC3269563

Pathogen-derived effectors trigger protective immunity via activation of the Rac2 enzyme and the IMD or Rip kinase signaling pathway.

Boyer L, Magoc L, Dejardin S, Cappillino M, Paquette N, Hinault C, Charriere GM, Ip WK, Fracchia S, Hennessy E, Erturk-Hasdemir D, Reichhart JM, Silverman N, Lacy-Hulbert A, Stuart LM
Immunity. 2011;35(4):536-49 - PMID: 22018470 - PMCID: PMC3258503

Image-based genome-wide siRNA screen identifies selective autophagy factors.

Orvedahl A, Sumpter R, Xiao G, Ng A, Zou Z, Tang Y, Narimatsu M, Gilpin C, Sun Q, Roth M, Forst CV, Wrana JL, Zhang YE, Luby-Phelps K, Xavier RJ, Xie Y, Levine B
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UV-C-irradiated Arabidopsis and tobacco emit volatiles that trigger genomic instability in neighboring plants.

Yao Y, Danna CH, Zemp FJ, Titov V, Ciftci ON, Przybylski R, Ausubel FM, Kovalchuk I
Plant Cell. 2011;23(10):3842-52 - PMID: 22028460 - PMCID: PMC3229153

Down-regulation of glutatione S-transferase ? 4 (hGSTA4) in the muscle of thermally injured patients is indicative of susceptibility to bacterial infection.

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CARMA1 is necessary for optimal T cell responses in a murine model of allergic asthma.

Ramadas RA, Roche MI, Moon JJ, Ludwig T, Xavier RJ, Medoff BD
J Immunol. 2011;187(12):6197-207 - PMID: 22075698 - PMCID: PMC3237896

PrimerBank: a PCR primer database for quantitative gene expression analysis, 2012 update.

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Nucleic Acids Res. 2011;40(Database issue):D1144-9 - PMID: 22086960 - PMCID: PMC3245149

Local injection of bevacizumab (Avastin) and angiolytic KTP laser treatment of recurrent respiratory papillomatosis of the vocal folds: a prospective study.

Zeitels SM, Barbu AM, Landau-Zemer T, Lopez-Guerra G, Burns JA, Friedman AD, Freeman MW, Halvorsen YD, Hillman RE
Ann Otol Rhinol Laryngol. 2011;120(10):627-34 - PMID: 22097147

The ERI-6/7 helicase acts at the first stage of an siRNA amplification pathway that targets recent gene duplications.

Fischer SE, Montgomery TA, Zhang C, Fahlgren N, Breen PC, Hwang A, Sullivan CM, Carrington JC, Ruvkun G
PLoS Genet. 2011;7(11):e1002369 - PMID: 22102828 - PMCID: PMC3213143

A genomic storm in critically injured humans.

Xiao W, Mindrinos MN, Seok J, Cuschieri J, Cuenca AG, Gao H, Hayden DL, Hennessy L, Moore EE, Minei JP, Bankey PE, Johnson JL, Sperry J, Nathens AB, Billiar TR, West MA, Brownstein BH, Mason PH, Baker HV, Finnerty CC, Jeschke MG, López MC, Klein MB, Gamelli RL, Gibran NS, Arnoldo B, Xu W, Zhang Y, Calvano SE, McDonald-Smith GP, Schoenfeld DA, Storey JD, Cobb JP, Warren HS, Moldawer LL, Herndon DN, Lowry SF, Maier RV, Davis RW, Tompkins RG,
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The Creating an Optimal Warfarin Nomogram (CROWN) Study.

Perlstein TS, Goldhaber SZ, Nelson K, Joshi V, Morgan TV, Lesko LJ, Lee JY, Gobburu J, Schoenfeld D, Kucherlapati R, Freeman MW, Creager MA
Thromb Haemost. 2011;107(1):59-68 - PMID: 22116191 - PMCID: PMC4133142

The C. elegans DAF-2 Insulin-Like Receptor is Abundantly Expressed in the Nervous System and Regulated by Nutritional Status.

Kimura KD, Riddle DL, Ruvkun G
Cold Spring Harb Symp Quant Biol. 2011;76:113-20 - PMID: 22123849

Bacterial effectors: learning on the fly.

Boyer L, Paquette N, Silverman N, Stuart LM
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Resuscitation-promoting factors are required for ?-lactam tolerance and the permeability barrier in Mycobacterium tuberculosis.

Wivagg CN, Hung DT
Antimicrob Agents Chemother. 2011;56(3):1591-4 - PMID: 22155826 - PMCID: PMC3294900

SILAM for quantitative proteomics of liver Akt1/PKB? after burn injury.

Lu XM, Tompkins RG, Fischman AJ
Int J Mol Med. 2011;29(3):461-71 - PMID: 22179310 - PMCID: PMC3981641

STAT6 phosphorylation inhibitors block eotaxin-3 secretion in bronchial epithelial cells.

Zhou L, Kawate T, Liu X, Kim YB, Zhao Y, Feng G, Banerji J, Nash H, Whitehurst C, Jindal S, Siddiqui A, Seed B, Wolfe JL
Bioorg Med Chem. 2011;20(2):750-8 - PMID: 22217933

ortho-Substituted C-aryl glucosides as highly potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.

Xu B, Feng Y, Lv B, Xu G, Zhang L, Du J, Peng K, Xu M, Dong J, Zhang W, Zhang T, Zhu L, Ding H, Sheng Z, Welihinda A, Seed B, Chen Y
Bioorg Med Chem. 2010;18(12):4422-32 - PMID: 20576578

Conformationally constrained spiro C-arylglucosides as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.

Lv B, Feng Y, Dong J, Xu M, Xu B, Zhang W, Sheng Z, Welihinda A, Seed B, Chen Y
ChemMedChem. 2010;5(6):827-31 - PMID: 20414917

Lipoprotein Metabolism and the Treatment of Lipid Disorders, Chapter 42. In: DeGroot LJ and JL Jameson, eds

MW Freeman
Endocrinology, 6th edition. 2010;:ePub

Analysis of high-throughput sequencing and annotation strategies for phage genomes.

Henn MR, Sullivan MB, Stange-Thomann N, Osburne MS, Berlin AM, Kelly L, Yandava C, Kodira C, Zeng Q, Weiand M, Sparrow T, Saif S, Giannoukos G, Young SK, Nusbaum C, Birren BW, Chisholm SW
PLoS One. 2010;5(2):e9083 - PMID: 20140207 - PMCID: PMC2816706

Differential expression of microRNA (miRNA) in chordoma reveals a role for miRNA-1 in Met expression.

Duan Z, Choy E, Nielsen GP, Rosenberg A, Iafrate J, Yang C, Schwab J, Mankin H, Xavier R, Hornicek FJ
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Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine.

Cadwell K, Patel KK, Maloney NS, Liu TC, Ng AC, Storer CE, Head RD, Xavier R, Stappenbeck TS, Virgin HW
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Differential innate immune signalling via Ca(2+) sensor protein kinases.

Boudsocq M, Willmann MR, McCormack M, Lee H, Shan L, He P, Bush J, Cheng SH, Sheen J
Nature. 2010;464(7287):418-22 - PMID: 20164835 - PMCID: PMC2841715

Protocol: a rapid and economical procedure for purification of plasmid or plant DNA with diverse applications in plant biology.

Li JF, Li L, Sheen J
Plant Methods. 2010;6(1):1 - PMID: 20180960 - PMCID: PMC2829548

Discover and connect cellular signaling.

Sheen J
Plant Physiol. 2010;154(2):562-6 - PMID: 20921185 - PMCID: PMC2949017

Autophagy at the gut interface: mucosal responses to stress and the consequences for inflammatory bowel diseases.

Huett A, Xavier RJ
Inflamm Bowel Dis. 2010;16(1):152-74 - PMID: 19575363 - PMCID: PMC3954538

Evolution of host innate defence: insights from Caenorhabditis elegans and primitive invertebrates.

Irazoqui JE, Urbach JM, Ausubel FM
Nat Rev Immunol. 2010;10(1):47-58 - PMID: 20029447 - PMCID: PMC2965059

Fluorosomes: a convenient new reagent to detect and block multivalent and complex receptor-ligand interactions.

Kueng HJ, Manta C, Haiderer D, Leb VM, Schmetterer KG, Neunkirchner A, Byrne RA, Scheinecker C, Steinberger P, Seed B, Pickl WF
FASEB J. 2010;24(5):1572-82 - PMID: 20056716 - PMCID: PMC2879947

Early acute kidney injury predicts progressive renal dysfunction and higher mortality in severely burned adults.

Mosier MJ, Pham TN, Klein MB, Gibran NS, Arnoldo BD, Gamelli RL, Tompkins RG, Herndon DN
J Burn Care Res. 2010;31(1):83-92 - PMID: 20061841 - PMCID: PMC3045668

bZIP transcription factor zip-2 mediates an early response to Pseudomonas aeruginosa infection in Caenorhabditis elegans.

Estes KA, Dunbar TL, Powell JR, Ausubel FM, Troemel ER
Proc Natl Acad Sci U S A. 2010;107(5):2153-8 - PMID: 20133860 - PMCID: PMC2836710

ABC transporters, atherosclerosis and inflammation.

Fitzgerald ML, Mujawar Z, Tamehiro N
Atherosclerosis. 2010;211(2):361-70 - PMID: 20138281 - PMCID: PMC2888932

The fast track to multidrug resistance.

Kaufmann BB, Hung DT
Mol Cell. 2010;37(3):297-8 - PMID: 20159549

Expanding roles for diverse physical phenomena during the origin of life.

Budin I, Szostak JW
Annu Rev Biophys. 2010;39:245-63 - PMID: 20192779 - PMCID: PMC4992673

Genome-wide association identifies multiple ulcerative colitis susceptibility loci.

McGovern DP, Gardet A, Törkvist L, Goyette P, Essers J, Taylor KD, Neale BM, Ong RT, Lagacé C, Li C, Green T, Stevens CR, Beauchamp C, Fleshner PR, Carlson M, D'Amato M, Halfvarson J, Hibberd ML, Lördal M, Padyukov L, Andriulli A, Colombo E, Latiano A, Palmieri O, Bernard EJ, Deslandres C, Hommes DW, de Jong DJ, Stokkers PC, Weersma RK, , Sharma Y, Silverberg MS, Cho JH, Wu J, Roeder K, Brant SR, Schumm LP, Duerr RH, Dubinsky MC, Glazer NL, Haritunians T, Ippoliti A, Melmed GY, Siscovick DS ...
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Exploring the interplay of barrier function and leukocyte recruitment in intestinal inflammation by targeting fucosyltransferase VII and trefoil factor 3.

Beck PL, Ihara E, Hirota SA, MacDonald JA, Meng D, Nanthakumar NN, Podolsky DK, Xavier RJ
Am J Physiol Gastrointest Liver Physiol. 2010;299(1):G43-53 - PMID: 20299601 - PMCID: PMC2904110

MLT-10 defines a family of DUF644 and proline-rich repeat proteins involved in the molting cycle of Caenorhabditis elegans.

Meli VS, Osuna B, Ruvkun G, Frand AR
Mol Biol Cell. 2010;21(10):1648-61 - PMID: 20335506 - PMCID: PMC2869372

Binding of PDZ-RhoGEF to ATP-binding cassette transporter A1 (ABCA1) induces cholesterol efflux through RhoA activation and prevention of transporter degradation.

Okuhira K, Fitzgerald ML, Tamehiro N, Ohoka N, Suzuki K, Sawada J, Naito M, Nishimaki-Mogami T
J Biol Chem. 2010;285(21):16369-77 - PMID: 20348106 - PMCID: PMC2871504

Innate immune responses activated in Arabidopsis roots by microbe-associated molecular patterns.

Millet YA, Danna CH, Clay NK, Songnuan W, Simon MD, Werck-Reichhart D, Ausubel FM
Plant Cell. 2010;22(3):973-90 - PMID: 20348432 - PMCID: PMC2861455

Effect of stalling after mismatches on the error catastrophe in nonenzymatic nucleic acid replication.

Rajamani S, Ichida JK, Antal T, Treco DA, Leu K, Nowak MA, Szostak JW, Chen IA
J Am Chem Soc. 2010;132(16):5880-5 - PMID: 20359213 - PMCID: PMC2857888

Host-encoded reporters for the detection and purification of multiple enveloped viruses.

Ketteler R, Tomov V, Neunkirchner A, Xie Q, Pickl WF, Seed B
J Virol Methods. 2010;167(2):178-85 - PMID: 20399809 - PMCID: PMC2916077

Identification of Drosophila Yin and PEPT2 as evolutionarily conserved phagosome-associated muramyl dipeptide transporters.

Charrière GM, Ip WE, Dejardin S, Boyer L, Sokolovska A, Cappillino MP, Cherayil BJ, Podolsky DK, Kobayashi KS, Silverman N, Lacy-Hulbert A, Stuart LM
J Biol Chem. 2010;285(26):20147-54 - PMID: 20406817 - PMCID: PMC2888427

Gene enrichment profiles reveal T-cell development, differentiation, and lineage-specific transcription factors including ZBTB25 as a novel NF-AT repressor.

Benita Y, Cao Z, Giallourakis C, Li C, Gardet A, Xavier RJ
Blood. 2010;115(26):5376-84 - PMID: 20410506 - PMCID: PMC2902135

99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: Caenorhabditis elegans as a model to study tissues involved in host immunity and microbial pathogenesis.

Irazoqui JE, Ausubel FM
Clin Exp Immunol. 2010;160(1):48-57 - PMID: 20415851 - PMCID: PMC2841835

Isolation and characterization of circulating tumor cells from patients with localized and metastatic prostate cancer.

Stott SL, Lee RJ, Nagrath S, Yu M, Miyamoto DT, Ulkus L, Inserra EJ, Ulman M, Springer S, Nakamura Z, Moore AL, Tsukrov DI, Kempner ME, Dahl DM, Wu CL, Iafrate AJ, Smith MR, Tompkins RG, Sequist LV, Toner M, Haber DA, Maheswaran S
Sci Transl Med. 2010;2(25):25ra23 - PMID: 20424012 - PMCID: PMC3141292

ZiFiT (Zinc Finger Targeter): an updated zinc finger engineering tool.

Sander JD, Maeder ML, Reyon D, Voytas DF, Joung JK, Dobbs D
Nucleic Acids Res. 2010;38(Web Server issue):W462-8 - PMID: 20435679 - PMCID: PMC2896148

Characterization and analysis of human chordoma cell lines.

Yang C, Hornicek FJ, Wood KB, Schwab JH, Choy E, Iafrate J, Rosenberg A, Nielsen GP, Xavier RJ, Mankin H, Duan Z
Spine (Phila Pa 1976). 2010;35(13):1257-64 - PMID: 20461036 - PMCID: PMC3769690

MiR-33 contributes to the regulation of cholesterol homeostasis.

Rayner KJ, Suárez Y, Dávalos A, Parathath S, Fitzgerald ML, Tamehiro N, Fisher EA, Moore KJ, Fernández-Hernando C
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Phagocytosis and phagosome acidification are required for pathogen processing and MyD88-dependent responses to Staphylococcus aureus.

Ip WK, Sokolovska A, Charriere GM, Boyer L, Dejardin S, Cappillino MP, Yantosca LM, Takahashi K, Moore KJ, Lacy-Hulbert A, Stuart LM
J Immunol. 2010;184(12):7071-81 - PMID: 20483752 - PMCID: PMC2935932

The origins of cellular life.

Schrum JP, Zhu TF, Szostak JW
Cold Spring Harb Perspect Biol. 2010;2(9):a002212 - PMID: 20484387 - PMCID: PMC2926753

Helical apolipoproteins of high-density lipoprotein enhance phagocytosis by stabilizing ATP-binding cassette transporter A7.

Tanaka N, Abe-Dohmae S, Iwamoto N, Fitzgerald ML, Yokoyama S
J Lipid Res. 2010;51(9):2591-9 - PMID: 20495215 - PMCID: PMC2918442

Berberine-INF55 (5-nitro-2-phenylindole) hybrid antimicrobials: effects of varying the relative orientation of the berberine and INF55 components.

Tomkiewicz D, Casadei G, Larkins-Ford J, Moy TI, Garner J, Bremner JB, Ausubel FM, Lewis K, Kelso MJ
Antimicrob Agents Chemother. 2010;54(8):3219-24 - PMID: 20498327 - PMCID: PMC2916310

High frequency targeted mutagenesis in Arabidopsis thaliana using zinc finger nucleases.

Zhang F, Maeder ML, Unger-Wallace E, Hoshaw JP, Reyon D, Christian M, Li X, Pierick CJ, Dobbs D, Peterson T, Joung JK, Voytas DF
Proc Natl Acad Sci U S A. 2010;107(26):12028-33 - PMID: 20508152 - PMCID: PMC2900673

Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes.

Westerberg LS, Meelu P, Baptista M, Eston MA, Adamovich DA, Cotta-de-Almeida V, Seed B, Rosen MK, Vandenberghe P, Thrasher AJ, Klein C, Alt FW, Snapper SB
J Exp Med. 2010;207(6):1145-52 - PMID: 20513746 - PMCID: PMC2882832

Mesenchymal stem cells: Mechanisms of immunomodulation and homing.

Yagi H, Soto-Gutierrez A, Parekkadan B, Kitagawa Y, Tompkins RG, Kobayashi N, Yarmush ML
Cell Transplant. 2010;19(6):667-79 - PMID: 20525442 - PMCID: PMC2957533

Mice lacking Dok-1, Dok-2, and Dok-3 succumb to aggressive histiocytic sarcoma.

Mashima R, Honda K, Yang Y, Morita Y, Inoue A, Arimura S, Nishina H, Ema H, Nakauchi H, Seed B, Oda H, Yamanashi Y
Lab Invest. 2010;90(9):1357-64 - PMID: 20548287

A systems biology viewpoint on autophagy in health and disease.

Huett A, Goel G, Xavier RJ
Curr Opin Gastroenterol. 2010;26(4):302-9 - PMID: 20571384

Bone marrow mesenchymal stromal cells attenuate organ injury induced by LPS and burn.

Yagi H, Soto-Gutierrez A, Kitagawa Y, Tilles AW, Tompkins RG, Yarmush ML
Cell Transplant. 2010;19(6):823-30 - PMID: 20573305 - PMCID: PMC2957544

The transcription factor MafB antagonizes antiviral responses by blocking recruitment of coactivators to the transcription factor IRF3.

Kim H, Seed B
Nat Immunol. 2010;11(8):743-50 - PMID: 20581830 - PMCID: PMC3050627

Human leucine-rich repeat proteins: a genome-wide bioinformatic categorization and functional analysis in innate immunity.

Ng AC, Eisenberg JM, Heath RJ, Huett A, Robinson CM, Nau GJ, Xavier RJ
Proc Natl Acad Sci U S A. 2010;108 Suppl 1:4631-8 - PMID: 20616063 - PMCID: PMC3063585

Distinct pathogenesis and host responses during infection of C. elegans by P. aeruginosa and S. aureus.

Irazoqui JE, Troemel ER, Feinbaum RL, Luhachack LG, Cezairliyan BO, Ausubel FM
PLoS Pathog. 2010;6:e1000982 - PMID: 20617181 - PMCID: PMC2895663

Circulating Nef induces dyslipidemia in simian immunodeficiency virus-infected macaques by suppressing cholesterol efflux.

Asztalos BF, Mujawar Z, Morrow MP, Grant A, Pushkarsky T, Wanke C, Shannon R, Geyer M, Kirchhoff F, Sviridov D, Fitzgerald ML, Bukrinsky M, Mansfield KG
J Infect Dis. 2010;202(4):614-23 - PMID: 20617930 - PMCID: PMC2932757

A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions.

Lipinski MM, Hoffman G, Ng A, Zhou W, Py BF, Hsu E, Liu X, Eisenberg J, Liu J, Blenis J, Xavier RJ, Yuan J
Dev Cell. 2010;18(6):1041-52 - PMID: 20627085 - PMCID: PMC2935848

Wnt signaling regulates mitochondrial physiology and insulin sensitivity.

Yoon JC, Ng A, Kim BH, Bianco A, Xavier RJ, Elledge SJ
Genes Dev. 2010;24(14):1507-18 - PMID: 20634317 - PMCID: PMC2904941

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease.

Lipinski MM, Zheng B, Lu T, Yan Z, Py BF, Ng A, Xavier RJ, Li C, Yankner BA, Scherzer CR, Yuan J
Proc Natl Acad Sci U S A. 2010;107(32):14164-9 - PMID: 20660724 - PMCID: PMC2922576

Reactive bone marrow stromal cells attenuate systemic inflammation via sTNFR1.

Yagi H, Soto-Gutierrez A, Navarro-Alvarez N, Nahmias Y, Goldwasser Y, Kitagawa Y, Tilles AW, Tompkins RG, Parekkadan B, Yarmush ML
Mol Ther. 2010;18(10):1857-64 - PMID: 20664529 - PMCID: PMC2951565

Effect of simvastatin on burn-induced alterations in tissue specific glucose metabolism: implications for burn associated insulin resistance.

Bonab AA, Carter EA, Paul K, Kaneki M, Yu YM, Tompkins RG, Fischman AJ
Int J Mol Med. 2010;26(3):311-6 - PMID: 20664945 - PMCID: PMC4090513

Engineering single Cys2His2 zinc finger domains using a bacterial cell-based two-hybrid selection system.

Thibodeau-Beganny S, Maeder ML, Joung JK
Methods Mol Biol. 2010;649:31-50 - PMID: 20680826

Burn injury reduces neutrophil directional migration speed in microfluidic devices.

Butler KL, Ambravaneswaran V, Agrawal N, Bilodeau M, Toner M, Tompkins RG, Fagan S, Irimia D
PLoS One. 2010;5(7):e11921 - PMID: 20689600 - PMCID: PMC2912851

Plasma proteome response to severe burn injury revealed by 18O-labeled "universal" reference-based quantitative proteomics.

Qian WJ, Petritis BO, Kaushal A, Finnerty CC, Jeschke MG, Monroe ME, Moore RJ, Schepmoes AA, Xiao W, Moldawer LL, Davis RW, Tompkins RG, Herndon DN, Camp DG, Smith RD,
J Proteome Res. 2010;9(9):4779-89 - PMID: 20698492 - PMCID: PMC2945297

Autonomous zinc-finger nuclease pairs for targeted chromosomal deletion.

Söllü C, Pars K, Cornu TI, Thibodeau-Beganny S, Maeder ML, Joung JK, Heilbronn R, Cathomen T
Nucleic Acids Res. 2010;38(22):8269-76 - PMID: 20716517 - PMCID: PMC3001086

Mutation of the ATP cassette binding transporter A1 (ABCA1) C-terminus disrupts HIV-1 Nef binding but does not block the Nef enhancement of ABCA1 protein degradation.

Mujawar Z, Tamehiro N, Grant A, Sviridov D, Bukrinsky M, Fitzgerald ML
Biochemistry. 2010;49(38):8338-49 - PMID: 20731376 - PMCID: PMC2943568

Human IRGM gene "to be or not to be".

Bekpen C, Xavier RJ, Eichler EE
Semin Immunopathol. 2010;32(4):437-44 - PMID: 20737271

Clinical microfluidics for neutrophil genomics and proteomics.

Kotz KT, Xiao W, Miller-Graziano C, Qian WJ, Russom A, Warner EA, Moldawer LL, De A, Bankey PE, Petritis BO, Camp DG, Rosenbach AE, Goverman J, Fagan SP, Brownstein BH, Irimia D, Xu W, Wilhelmy J, Mindrinos MN, Smith RD, Davis RW, Tompkins RG, Toner M,
Nat Med. 2010;16(9):1042-7 - PMID: 20802500 - PMCID: PMC3136804

Single-molecule binding experiments on long time scales.

Elenko MP, Szostak JW, van Oijen AM
Rev Sci Instrum. 2010;81(8):083705 - PMID: 20815611

DNA ends: just the beginning (Nobel lecture).

Szostak JW
Angew Chem Int Ed Engl. 2010;49(41):7386-404 - PMID: 20818632

Stem cells and burns: review and therapeutic implications.

Butler KL, Goverman J, Ma H, Fischman A, Yu YM, Bilodeau M, Rad AM, Bonab AA, Tompkins RG, Fagan SP
J Burn Care Res. 2010;31(6):874-81 - PMID: 20859216

NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis.

Hirota SA, Ng J, Lueng A, Khajah M, Parhar K, Li Y, Lam V, Potentier MS, Ng K, Bawa M, McCafferty DM, Rioux KP, Ghosh S, Xavier RJ, Colgan SP, Tschopp J, Muruve D, MacDonald JA, Beck PL
Inflamm Bowel Dis. 2010;17(6):1359-72 - PMID: 20872834 - PMCID: PMC3026862

Morphology-guided graph search for untangling objects: C. elegans analysis.

Raviv TR, Ljosa V, Conery AL, Ausubel FM, Carpenter AE, Golland P, Wählby C
Med Image Comput Comput Assist Interv. 2010;13(Pt 3):634-41 - PMID: 20879454 - PMCID: PMC3050593

LRRK2 is involved in the IFN-gamma response and host response to pathogens.

Gardet A, Benita Y, Li C, Sands BE, Ballester I, Stevens C, Korzenik JR, Rioux JD, Daly MJ, Xavier RJ, Podolsky DK
J Immunol. 2010;185(9):5577-85 - PMID: 20921534 - PMCID: PMC3156100

Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection.

Riley BE, Kaiser SE, Shaler TA, Ng AC, Hara T, Hipp MS, Lage K, Xavier RJ, Ryu KY, Taguchi K, Yamamoto M, Tanaka K, Mizushima N, Komatsu M, Kopito RR
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The contribution of muscle to whole-body protein turnover throughout the course of burn injury in children.

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RESOLVING CLUSTERED WORMS VIA PROBABILISTIC SHAPE MODELS.

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Selective activation of nuclear factor kappa B in the cochlea by sensory and inflammatory stress.

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Regulation of signaling pathways downstream of IGF-I/insulin by androgen in skeletal muscle of glucocorticoid-treated rats.

Yin HN, Chai JK, Yu YM, Shen CA, Wu YQ, Yao YM, Liu H, Liang LM, Tompkins RG, Sheng ZY
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Lv B, Xu B, Feng Y, Peng K, Xu G, Du J, Zhang L, Zhang W, Zhang T, Zhu L, Ding H, Sheng Z, Welihinda A, Seed B, Chen Y
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Building complex biological networks based upon model organisms: mapping the human autophagy interactome via a hybrid yeast-human protein interaction network.

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The G protein-coupled receptor FSHR-1 is required for the Caenorhabditis elegans innate immune response.

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Proc Natl Acad Sci U S A. 2009;106(8):2782-7 - PMID: 19196974 - PMCID: PMC2650343

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A functional genomic screen identifies cellular cofactors of hepatitis C virus replication.

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A novel hybrid yeast-human network analysis reveals an essential role for FNBP1L in antibacterial autophagy.

Huett A, Ng A, Cao Z, Kuballa P, Komatsu M, Daly MJ, Podolsky DK, Xavier RJ
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Exp Cell Res. 2009;315(12):2001-11 - PMID: 19371741 - PMCID: PMC2693461

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Proc Natl Acad Sci U S A. 2009;106(17):7263 - PMID: 19380733 - PMCID: PMC2678432

Long-term superior performance of a stem cell/hepatocyte device for the treatment of acute liver failure.

Yagi H, Parekkadan B, Suganuma K, Soto-Gutierrez A, Tompkins RG, Tilles AW, Yarmush ML
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Enhancing the performance of a point-of-care CD4+ T-cell counting microchip through monocyte depletion for HIV/AIDS diagnostics.

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An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia.

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Microarray analysis suggests that burn injury results in mitochondrial dysfunction in human skeletal muscle.

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Effect of insulin levels on the phosphorylation of specific amino acid residues in IRS-1: implications for burn-induced insulin resistance.

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Validation of the riboleukogram to detect ventilator-associated pneumonia after severe injury.

Cobb JP, Moore EE, Hayden DL, Minei JP, Cuschieri J, Yang J, Li Q, Lin N, Brownstein BH, Hennessy L, Mason PH, Schierding WS, Dixon DJ, Tompkins RG, Warren HS, Schoenfeld DA, Maier RV
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Reconstructing the emergence of cellular life through the synthesis of model protocells.

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Cold Spring Harb Symp Quant Biol. 2009;74:47-54 - PMID: 19734203

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Identification of antifungal compounds active against Candida albicans using an improved high-throughput Caenorhabditis elegans assay.

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Efficient and rapid template-directed nucleic acid copying using 2'-amino-2',3'-dideoxyribonucleoside-5'-phosphorimidazolide monomers.

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Oligomerized pool engineering (OPEN): an 'open-source' protocol for making customized zinc-finger arrays.

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Common variants at five new loci associated with early-onset inflammatory bowel disease.

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The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus.

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Myelinated, synapsing cultures of murine spinal cord--validation as an in vitro model of the central nervous system.

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Eur J Neurosci. 2008;28(8):1518-35 - PMID: 18793322 - PMCID: PMC2777255

Targeting innate immunity for CV benefit

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Drug Discovery Today: Therapeutic Strategies. 2008;5:15-23

Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergence.

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cDNA sequences for transcription factors and signaling proteins of the hemichordate Saccoglossus kowalevskii: efficacy of the expressed sequence tag (EST) approach for evolutionary and developmental studies of a new organism.

Freeman RM, Wu M, Cordonnier-Pratt MM, Pratt LH, Gruber CE, Smith M, Lander ES, Stange-Thomann N, Lowe CJ, Gerhart J, Kirschner M
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SNPping away at the pathogenesis of Crohn's disease.

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Inflamm Bowel Dis. 2008;14(1):136-7 - PMID: 17941076

The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response.

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The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells.

Zhou D, Medoff BD, Chen L, Li L, Zhang XF, Praskova M, Liu M, Landry A, Blumberg RS, Boussiotis VA, Xavier R, Avruch J
Proc Natl Acad Sci U S A. 2008;105(51):20321-6 - PMID: 19073936 - PMCID: PMC2600581

Rassf family of tumor suppressor polypeptides.

Avruch J, Xavier R, Bardeesy N, Zhang XF, Praskova M, Zhou D, Xia F
J Biol Chem. 2008;284(17):11001-5 - PMID: 19091744 - PMCID: PMC2670104

Sugar sensing and signaling.

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Arabidopsis Book. 2008;6:e0117 - PMID: 22303242 - PMCID: PMC3243355

Dual control of nuclear EIN3 by bifurcate MAPK cascades in C2H4 signalling.

Yoo SD, Cho YH, Tena G, Xiong Y, Sheen J
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Cytokinin and auxin interaction in root stem-cell specification during early embryogenesis.

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Nature. 2008;453(7198):1094-7 - PMID: 18463635 - PMCID: PMC2601652

Expression and evolutionary features of the hexokinase gene family in Arabidopsis.

Karve A, Rauh BL, Xia X, Kandasamy M, Meagher RB, Sheen J, Moore BD
Planta. 2008;228(3):411-25 - PMID: 18481082 - PMCID: PMC2953952

Bacterial effectors target the common signaling partner BAK1 to disrupt multiple MAMP receptor-signaling complexes and impede plant immunity.

Shan L, He P, Li J, Heese A, Peck SC, Nürnberger T, Martin GB, Sheen J
Cell Host Microbe. 2008;4(1):17-27 - PMID: 18621007 - PMCID: PMC2830012

Convergent energy and stress signaling.

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Trends Plant Sci. 2008;13(9):474-82 - PMID: 18701338 - PMCID: PMC3075853

IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis.

Sugimoto K, Ogawa A, Mizoguchi E, Shimomura Y, Andoh A, Bhan AK, Blumberg RS, Xavier RJ, Mizoguchi A
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Mannose-binding lectin enhances Toll-like receptors 2 and 6 signaling from the phagosome.

Ip WK, Takahashi K, Moore KJ, Stuart LM, Ezekowitz RA
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Pierce ML, Weston MD, Fritzsch B, Gabel HW, Ruvkun G, Soukup GA
Evol Dev. 2008;10(1):106-13 - PMID: 18184361 - PMCID: PMC2637451

Identification of host proteins required for HIV infection through a functional genomic screen.

Brass AL, Dykxhoorn DM, Benita Y, Yan N, Engelman A, Xavier RJ, Lieberman J, Elledge SJ
Science. 2008;319(5865):921-6 - PMID: 18187620

Defective signal transduction in B lymphocytes lacking presenilin proteins.

Yagi T, Giallourakis C, Mohanty S, Scheidig C, Shen J, Zheng H, Xavier RJ, Shaw AC
Proc Natl Acad Sci U S A. 2008;105(3):979-84 - PMID: 18195359 - PMCID: PMC2242696

Reduced rate of adenosine triphosphate synthesis by in vivo 31P nuclear magnetic resonance spectroscopy and downregulation of PGC-1beta in distal skeletal muscle following burn.

Tzika AA, Mintzopoulos D, Padfield K, Wilhelmy J, Mindrinos MN, Yu H, Cao H, Zhang Q, Astrakas LG, Zhang J, Yu YM, Rahme LG, Tompkins RG
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Phagocytosis and comparative innate immunity: learning on the fly.

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Nat Rev Immunol. 2008;8(2):131-41 - PMID: 18219310

Influence of age on the association of retinol-binding protein 4 with metabolic syndrome.

Gavi S, Qurashi S, Stuart LM, Lau R, Melendez MM, Mynarcik DC, McNurlan MA, Gelato MC
Obesity (Silver Spring). 2008;16(4):893-5 - PMID: 18239568

Invention, innovation, entrepreneurship in academic medical centers.

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Surgery. 2008;143(2):168-71 - PMID: 18242329 - PMCID: PMC2408552

DAF-16-dependent suppression of immunity during reproduction in Caenorhabditis elegans.

Miyata S, Begun J, Troemel ER, Ausubel FM
Genetics. 2008;178(2):903-18 - PMID: 18245330 - PMCID: PMC2248360

Autophagy as an important process in gut homeostasis and Crohn's disease pathogenesis.

Xavier RJ, Huett A, Rioux JD
Gut. 2008;57(6):717-20 - PMID: 18272545 - PMCID: PMC2735854

Equilibrium separation and filtration of particles using differential inertial focusing.

Di Carlo D, Edd JF, Irimia D, Tompkins RG, Toner M
Anal Chem. 2008;80(6):2204-11 - PMID: 18275222

Defining molecular classifications and targets in gastroenteropancreatic neuroendocrine tumors through DNA microarray analysis.

Duerr EM, Mizukami Y, Ng A, Xavier RJ, Kikuchi H, Deshpande V, Warshaw AL, Glickman J, Kulke MH, Chung DC
Endocr Relat Cancer. 2008;15(1):243-56 - PMID: 18310291

Engineering Cys2His2 zinc finger domains using a bacterial cell-based two-hybrid selection system.

Thibodeau-Beganny S, Joung JK
Methods Mol Biol. 2008;408:317-34 - PMID: 18314590

Metal-ion catalyzed polymerization in the eutectic phase in water-ice: a possible approach to template-directed RNA polymerization.

Monnard PA, Szostak JW
J Inorg Biochem. 2008;102(5-6):1104-11 - PMID: 18329104

Comparison of zinc finger nucleases for use in gene targeting in mammalian cells.

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Mol Ther. 2008;16(4):707-17 - PMID: 18334988

A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein.

Schöbel S, Neumann S, Hertweck M, Dislich B, Kuhn PH, Kremmer E, Seed B, Baumeister R, Haass C, Lichtenthaler SF
J Biol Chem. 2008;283(21):14257-68 - PMID: 18353773

Burn-related metabolic and signaling changes in rat brain.

Zhang Q, Carter EA, Ma B, Fischman AJ, Tompkins RG
J Burn Care Res. 2008;29(2):346-52 - PMID: 18354292

Increased uncoupling protein 1 mRNA expression in mice brown adipose tissue after burn injury.

Zhang Q, Ma B, Fischman AJ, Tompkins RG, Carter EA
J Burn Care Res. 2008;29(2):358-62 - PMID: 18354294

Models of Caenorhabditis elegans infection by bacterial and fungal pathogens.

Powell JR, Ausubel FM
Methods Mol Biol. 2008;415:403-27 - PMID: 18370168

Microfluidic leukocyte isolation for gene expression analysis in critically ill hospitalized patients.

Russom A, Sethu P, Irimia D, Mindrinos MN, Calvano SE, Garcia I, Finnerty C, Tannahill C, Abouhamze A, Wilhelmy J, López MC, Baker HV, Herndon DN, Lowry SF, Maier RV, Davis RW, Moldawer LL, Tompkins RG, Toner M,
Clin Chem. 2008;54(5):891-900 - PMID: 18375483 - PMCID: PMC4011019

A pathway sensor for genome-wide screens of intracellular proteolytic cleavage.

Ketteler R, Sun Z, Kovacs KF, He WW, Seed B
Genome Biol. 2008;9(4):R64 - PMID: 18387192 - PMCID: PMC2643935

Comparing insertion libraries in two Pseudomonas aeruginosa strains to assess gene essentiality.

Liberati NT, Urbach JM, Thurber TK, Wu G, Ausubel FM
Methods Mol Biol. 2008;416:153-69 - PMID: 18392966

Ribosomal synthesis of N-methyl peptides.

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J Am Chem Soc. 2008;130(19):6131-6 - PMID: 18402453 - PMCID: PMC2728122

Spinophilin and the immune synapse.

Seed B, Xavier R
J Cell Biol. 2008;181(2):181-3 - PMID: 18411314 - PMCID: PMC2315665

Identification of Caenorhabditis elegans genes regulating longevity using enhanced RNAi-sensitive strains.

Samuelson AV, Klimczak RR, Thompson DB, Carr CE, Ruvkun G
Cold Spring Harb Symp Quant Biol. 2008;72:489-97 - PMID: 18419309

The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi.

Gabel HW, Ruvkun G
Nat Struct Mol Biol. 2008;15(5):531-3 - PMID: 18438419 - PMCID: PMC2910399

Activation of defense response pathways by OGs and Flg22 elicitors in Arabidopsis seedlings.

Denoux C, Galletti R, Mammarella N, Gopalan S, Werck D, De Lorenzo G, Ferrari S, Ausubel FM, Dewdney J
Mol Plant. 2008;1(3):423-45 - PMID: 19825551 - PMCID: PMC2954645

Unexpected failure rates for modular assembly of engineered zinc fingers.

Ramirez CL, Foley JE, Wright DA, Müller-Lerch F, Rahman SH, Cornu TI, Winfrey RJ, Sander JD, Fu F, Townsend JA, Cathomen T, Voytas DF, Joung JK
Nat Methods. 2008;5(5):374-5 - PMID: 18446154

SPTLC1 binds ABCA1 to negatively regulate trafficking and cholesterol efflux activity of the transporter.

Tamehiro N, Zhou S, Okuhira K, Benita Y, Brown CE, Zhuang DZ, Latz E, Hornemann T, von Eckardstein A, Xavier RJ, Freeman MW, Fitzgerald ML
Biochemistry. 2008;47(23):6138-47 - PMID: 18484747 - PMCID: PMC2504083

Estimating glutathione synthesis with deuterated water: a model for peptide biosynthesis.

Cabral CB, Bullock KH, Bischoff DJ, Tompkins RG, Yu YM, Kelleher JK
Anal Biochem. 2008;379(1):40-4 - PMID: 18486587 - PMCID: PMC4065382

Neither hide nor hair: the difficulty of identifying useful disease biomarkers.

Huett A, Xavier RJ
Gastroenterology. 2008;134(7):2164-8 - PMID: 18486617

Genetic identification of HSD-1, a conserved steroidogenic enzyme that directs larval development in Caenorhabditis elegans.

Patel DS, Fang LL, Svy DK, Ruvkun G, Li W
Development. 2008;135(13):2239-49 - PMID: 18495818

Murine intramyocellular lipids quantified by NMR act as metabolic biomarkers in burn trauma.

Tzika AA, Astrakas LG, Cao H, Mintzopoulos D, Zhang Q, Padfield K, Yu H, Mindrinos MN, Rahme LG, Tompkins RG
Int J Mol Med. 2008;21(6):825-32 - PMID: 18506378

The microRNA miR-1 regulates a MEF-2-dependent retrograde signal at neuromuscular junctions.

Simon DJ, Madison JM, Conery AL, Thompson-Peer KL, Soskis M, Ruvkun GB, Kaplan JM, Kim JK
Cell. 2008;133(5):903-15 - PMID: 18510933 - PMCID: PMC2553566

Template-directed synthesis of a genetic polymer in a model protocell.

Mansy SS, Schrum JP, Krishnamurthy M, Tobé S, Treco DA, Szostak JW
Nature. 2008;454(7200):122-5 - PMID: 18528332 - PMCID: PMC2743009

Animal models for host-pathogen interactions.

Lemaitre B, Ausubel FM
Curr Opin Microbiol. 2008;11(3):249-50 - PMID: 18539076

Zinc-finger nucleases: the next generation emerges.

Cathomen T, Joung JK
Mol Ther. 2008;16(7):1200-7 - PMID: 18545224

Temporal cytokine profiles in severely burned patients: a comparison of adults and children.

Finnerty CC, Jeschke MG, Herndon DN, Gamelli R, Gibran N, Klein M, Silver G, Arnoldo B, Remick D, Tompkins RG,
Mol Med. 2008;14(9-10):553-60 - PMID: 18548133 - PMCID: PMC2424320

Tiny RNA: Where do we come from? What are we? Where are we going?

Ruvkun G
Trends Plant Sci. 2008;13(7):313-6 - PMID: 18562240

Attenuation of Pseudomonas aeruginosa virulence by medicinal plants in a Caenorhabditis elegans model system.

Adonizio A, Leal SM, Ausubel FM, Mathee K
J Med Microbiol. 2008;57(Pt 7):809-13 - PMID: 18566137

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.

Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, Brant SR, Silverberg MS, Taylor KD, Barmada MM, Bitton A, Dassopoulos T, Datta LW, Green T, Griffiths AM, Kistner EO, Murtha MT, Regueiro MD, Rotter JI, Schumm LP, Steinhart AH, Targan SR, Xavier RJ, , Libioulle C, Sandor C, Lathrop M, Belaiche J, Dewit O, Gut I, Heath S, Laukens D, Mni M, Rutgeerts P, Van Gossum A, Zelenika D, Franchimont D, Hugot JP, de Vos M, Vermeire S, Louis E, , , Cardon LR, Anderson CA, Drummond H, Nimm ...
Nat Genet. 2008;40(8):955-62 - PMID: 18587394 - PMCID: PMC2574810

Detection of mutations in EGFR in circulating lung-cancer cells.

Maheswaran S, Sequist LV, Nagrath S, Ulkus L, Brannigan B, Collura CV, Inserra E, Diederichs S, Iafrate AJ, Bell DW, Digumarthy S, Muzikansky A, Irimia D, Settleman J, Tompkins RG, Lynch TJ, Toner M, Haber DA
N Engl J Med. 2008;359(4):366-77 - PMID: 18596266 - PMCID: PMC3551471

Quantitation of autophagy by luciferase release assay.

Ketteler R, Seed B
Autophagy. 2008;4(6):801-6 - PMID: 18641457 - PMCID: PMC2910585

MAST3: a novel IBD risk factor that modulates TLR4 signaling.

Labbé C, Goyette P, Lefebvre C, Stevens C, Green T, Tello-Ruiz MK, Cao Z, Landry AL, Stempak J, Annese V, Latiano A, Brant SR, Duerr RH, Taylor KD, Cho JH, Steinhart AH, Daly MJ, Silverberg MS, Xavier RJ, Rioux JD
Genes Immun. 2008;9(7):602-12 - PMID: 18650832 - PMCID: PMC2574831

Genome-wide association studies: a new window into immune-mediated diseases.

Xavier RJ, Rioux JD
Nat Rev Immunol. 2008;8(8):631-43 - PMID: 18654571 - PMCID: PMC2750781

Hoxc6 is overexpressed in gastrointestinal carcinoids and interacts with JunD to regulate tumor growth.

Fujiki K, Duerr EM, Kikuchi H, Ng A, Xavier RJ, Mizukami Y, Imamura T, Kulke MH, Chung DC
Gastroenterology. 2008;135(3):907-16, 916.e1-2 - PMID: 18655788 - PMCID: PMC3777410

Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification.

Maeder ML, Thibodeau-Beganny S, Osiak A, Wright DA, Anthony RM, Eichtinger M, Jiang T, Foley JE, Winfrey RJ, Townsend JA, Unger-Wallace E, Sander JD, Müller-Lerch F, Fu F, Pearlberg J, Göbel C, Dassie JP, Pruett-Miller SM, Porteus MH, Sgroi DC, Iafrate AJ, Dobbs D, McCray PB, Cathomen T, Voytas DF, Joung JK
Mol Cell. 2008;31(2):294-301 - PMID: 18657511 - PMCID: PMC2535758

RNA interference screen for human genes associated with West Nile virus infection.

Krishnan MN, Ng A, Sukumaran B, Gilfoy FD, Uchil PD, Sultana H, Brass AL, Adametz R, Tsui M, Qian F, Montgomery RR, Lev S, Mason PW, Koski RA, Elledge SJ, Xavier RJ, Agaisse H, Fikrig E
Nature. 2008;455(7210):242-5 - PMID: 18690214 - PMCID: PMC3136529

CARMA3 mediates lysophosphatidic acid-stimulated cytokine secretion by bronchial epithelial cells.

Medoff BD, Landry AL, Wittbold KA, Sandall BP, Derby MC, Cao Z, Adams JC, Xavier RJ
Am J Respir Cell Mol Biol. 2008;40(3):286-94 - PMID: 18757306 - PMCID: PMC2645526

Thermostability of model protocell membranes.

Mansy SS, Szostak JW
Proc Natl Acad Sci U S A. 2008;105(36):13351-5 - PMID: 18768808 - PMCID: PMC2528865

Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7.

Fischer SE, Butler MD, Pan Q, Ruvkun G
Nature. 2008;455(7212):491-6 - PMID: 18784652 - PMCID: PMC2756026

The AtrbohD-mediated oxidative burst elicited by oligogalacturonides in Arabidopsis is dispensable for the activation of defense responses effective against Botrytis cinerea.

Galletti R, Denoux C, Gambetta S, Dewdney J, Ausubel FM, De Lorenzo G, Ferrari S
Plant Physiol. 2008;148(3):1695-706 - PMID: 18790995 - PMCID: PMC2577270

Zinc Finger Database (ZiFDB): a repository for information on C2H2 zinc fingers and engineered zinc-finger arrays.

Fu F, Sander JD, Maeder M, Thibodeau-Beganny S, Joung JK, Dobbs D, Miller L, Voytas DF
Nucleic Acids Res. 2008;37(Database issue):D279-83 - PMID: 18812396 - PMCID: PMC2686427

A microfluidics approach for the isolation of nucleated red blood cells (NRBCs) from the peripheral blood of pregnant women.

Huang R, Barber TA, Schmidt MA, Tompkins RG, Toner M, Bianchi DW, Kapur R, Flejter WL
Prenat Diagn. 2008;28(10):892-9 - PMID: 18821715 - PMCID: PMC4482103

Selection of cyclic peptide aptamers to HCV IRES RNA using mRNA display.

Litovchick A, Szostak JW
Proc Natl Acad Sci U S A. 2008;105(40):15293-8 - PMID: 18824687 - PMCID: PMC2556359

The perfect storm of tiny RNAs.

Ruvkun G
Nat Med. 2008;14(10):1041-5 - PMID: 18841145

Impact of oxandrolone treatment on acute outcomes after severe burn injury.

Pham TN, Klein MB, Gibran NS, Arnoldo BD, Gamelli RL, Silver GM, Jeschke MG, Finnerty CC, Tompkins RG, Herndon DN
J Burn Care Res. 2008;29(6):902-6 - PMID: 18849836 - PMCID: PMC3958934

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells.

Cadwell K, Liu JY, Brown SL, Miyoshi H, Loh J, Lennerz JK, Kishi C, Kc W, Carrero JA, Hunt S, Stone CD, Brunt EM, Xavier RJ, Sleckman BP, Li E, Mizushima N, Stappenbeck TS, Virgin HW
Nature. 2008;456(7219):259-63 - PMID: 18849966 - PMCID: PMC2695978

Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant.

Kuballa P, Huett A, Rioux JD, Daly MJ, Xavier RJ
PLoS One. 2008;3(10):e3391 - PMID: 18852889 - PMCID: PMC2566595

The most conserved genome segments for life detection on Earth and other planets.

Isenbarger TA, Carr CE, Johnson SS, Finney M, Church GM, Gilbert W, Zuber MT, Ruvkun G
Orig Life Evol Biosph. 2008;38(6):517-33 - PMID: 18853276

Early supplemental parenteral nutrition is associated with increased infectious complications in critically ill trauma patients.

Sena MJ, Utter GH, Cuschieri J, Maier RV, Tompkins RG, Harbrecht BG, Moore EE, O'Keefe GE
J Am Coll Surg. 2008;207(4):459-67 - PMID: 18926446 - PMCID: PMC4002002

Loss of SR-A and CD36 activity reduces atherosclerotic lesion complexity without abrogating foam cell formation in hyperlipidemic mice.

Manning-Tobin JJ, Moore KJ, Seimon TA, Bell SA, Sharuk M, Alvarez-Leite JI, de Winther MP, Tabas I, Freeman MW
Arterioscler Thromb Vasc Biol. 2008;29(1):19-26 - PMID: 18948635 - PMCID: PMC2666043

ABCA12 maintains the epidermal lipid permeability barrier by facilitating formation of ceramide linoleic esters.

Zuo Y, Zhuang DZ, Han R, Isaac G, Tobin JJ, McKee M, Welti R, Brissette JL, Fitzgerald ML, Freeman MW
J Biol Chem. 2008;283(52):36624-35 - PMID: 18957418 - PMCID: PMC2605993

Role for beta-catenin and HOX transcription factors in Caenorhabditis elegans and mammalian host epithelial-pathogen interactions.

Irazoqui JE, Ng A, Xavier RJ, Ausubel FM
Proc Natl Acad Sci U S A. 2008;105(45):17469-74 - PMID: 18981407 - PMCID: PMC2582251

Fat metabolism links germline stem cells and longevity in C. elegans.

Wang MC, O'Rourke EJ, Ruvkun G
Science. 2008;322(5903):957-60 - PMID: 18988854 - PMCID: PMC2760269

Deficiency of mannose-binding lectin greatly increases antibody response in a mouse model of vaccination.

Guttormsen HK, Stuart LM, Shi L, Carroll MC, Chen J, Kasper DL, Ezekowitz RA, Takahashi K
Clin Immunol. 2008;130(3):264-71 - PMID: 18996748 - PMCID: PMC2660855

An affinity-based scoring scheme for predicting DNA-binding activities of modularly assembled zinc-finger proteins.

Sander JD, Zaback P, Joung JK, Voytas DF, Dobbs D
Nucleic Acids Res. 2008;37(2):506-15 - PMID: 19056825 - PMCID: PMC2632909

A metasystem of framework model organisms to study emergence of new host-microbe adaptations.

Gopalan S, Ausubel FM
PLoS One. 2008;3(12):e3891 - PMID: 19066631 - PMCID: PMC2588659

Microsporidia are natural intracellular parasites of the nematode Caenorhabditis elegans.

Troemel ER, Félix MA, Whiteman NK, Barrière A, Ausubel FM
PLoS Biol. 2008;6(12):2736-52 - PMID: 19071962 - PMCID: PMC2596862

Gene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis.

Goyette P, Lefebvre C, Ng A, Brant SR, Cho JH, Duerr RH, Silverberg MS, Taylor KD, Latiano A, Aumais G, Deslandres C, Jobin G, Annese V, Daly MJ, Xavier RJ, Rioux JD
Mucosal Immunol. 2008;1(2):131-8 - PMID: 19079170 - PMCID: PMC4550306

Sensitive, specific polymorphism discovery in bacteria using massively parallel sequencing.

Nusbaum C, Ohsumi TK, Gomez J, Aquadro J, Victor TC, Warren RM, Hung DT, Birren BW, Lander ES, Jaffe DB
Nat Methods. 2008;6(1):67-9 - PMID: 19079253 - PMCID: PMC2613166

Glucosinolate metabolites required for an Arabidopsis innate immune response.

Clay NK, Adio AM, Denoux C, Jander G, Ausubel FM
Science. 2008;323(5910):95-101 - PMID: 19095898 - PMCID: PMC2630859

A comprehensive collection of experimentally validated primers for Polymerase Chain Reaction quantitation of murine transcript abundance.

Spandidos A, Wang X, Wang H, Dragnev S, Thurber T, Seed B
BMC Genomics. 2008;9:633 - PMID: 19108745 - PMCID: PMC2631021

Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway.

Hitomi J, Christofferson DE, Ng A, Yao J, Degterev A, Xavier RJ, Yuan J
Cell. 2008;135(7):1311-23 - PMID: 19109899 - PMCID: PMC2621059

Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease.

McCarroll SA, Huett A, Kuballa P, Chilewski SD, Landry A, Goyette P, Zody MC, Hall JL, Brant SR, Cho JH, Duerr RH, Silverberg MS, Taylor KD, Rioux JD, Altshuler D, Daly MJ, Xavier RJ
Nat Genet. 2008;40(9):1107-12 - PMID: 19165925 - PMCID: PMC2731799

Genome-wide transcriptome analysis of 150 cell samples.

Irimia D, Mindrinos M, Russom A, Xiao W, Wilhelmy J, Wang S, Heath JD, Kurn N, Tompkins RG, Davis RW, Toner M
Integr Biol (Camb). 2008;1(1):99-107 - PMID: 20023796 - PMCID: PMC3763906

Evolution of genes and genomes on the Drosophila phylogeny.

Drosophila 12 Genomes Consortium, Clark AG, Eisen MB, Smith DR, Bergman CM, Oliver B, Markow TA, Kaufman TC, Kellis M, Gelbart W, Iyer VN, Pollard DA, Sackton TB, Larracuente AM, Singh ND, Abad JP, Abt DN, Adryan B, Aguade M, Akashi H, Anderson WW, Aquadro CF, Ardell DH, Arguello R, Artieri CG, Barbash DA, Barker D, Barsanti P, Batterham P, Batzoglou S, Begun D, Bhutkar A, Blanco E, Bosak SA, Bradley RK, Brand AD, Brent MR, Brooks AN, Brown RH, Butlin RK, Caggese C, Calvi BR, Bernardo de Car ...
Nature. 2007;450(7167):203-18 - PMID: 17994087

DLGH1 is a negative regulator of T-lymphocyte proliferation.

Stephenson LM, Sammut B, Graham DB, Chan-Wang J, Brim KL, Huett AS, Miletic AV, Kloeppel T, Landry A, Xavier R, Swat W
Mol Cell Biol. 2007;27(21):7574-81 - PMID: 17724087 - PMCID: PMC2169038

Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development.

Cotta-de-Almeida V, Westerberg L, Maillard MH, Onaldi D, Wachtel H, Meelu P, Chung UI, Xavier R, Alt FW, Snapper SB
Proc Natl Acad Sci U S A. 2007;104(39):15424-9 - PMID: 17878299 - PMCID: PMC2000553

Glucose signaling through nuclear hexokinase1 complex in Arabidopsis.

Cho YH, Yoo SD, Sheen J
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Nuclear actions in innate immune signaling.

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Elicitation and suppression of microbe-associated molecular pattern-triggered immunity in plant-microbe interactions.

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Arabidopsis mesophyll protoplasts: a versatile cell system for transient gene expression analysis.

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A central integrator of transcription networks in plant stress and energy signalling.

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The N-terminal region of Pseudomonas type III effector AvrPtoB elicits Pto-dependent immunity and has two distinct virulence determinants.

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Advances in cytokinin signaling.

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Intercepting host MAPK signaling cascades by bacterial type III effectors.

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The bacterial two-hybrid system as a reporter system for analyzing protein-protein interactions.

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Antifungal chemical compounds identified using a C. elegans pathogenicity assay.

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Virstatin inhibits dimerization of the transcriptional activator ToxT.

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Retinol-binding protein 4 is associated with insulin resistance and body fat distribution in nonobese subjects without type 2 diabetes.

Gavi S, Stuart LM, Kelly P, Melendez MM, Mynarcik DC, Gelato MC, McNurlan MA
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Genetic etiology of isolated low HDL syndrome: incidence and heterogeneity of efflux defects.

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2',3'-Dideoxy-3'-thionucleoside triphosphates: syntheses and polymerase substrate activities.

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Standard operating procedures for the clinical management of patients enrolled in a prospective study of Inflammation and the Host Response to Thermal Injury.

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Resistance to Botrytis cinerea induced in Arabidopsis by elicitors is independent of salicylic acid, ethylene, or jasmonate signaling but requires PHYTOALEXIN DEFICIENT3.

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Standardized reagents and protocols for engineering zinc finger nucleases by modular assembly.

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The practice of venous thromboembolism prophylaxis in the major trauma patient.

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The association between fluid administration and outcome following major burn: a multicenter study.

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A microchip approach for practical label-free CD4+ T-cell counting of HIV-infected subjects in resource-poor settings.

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Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis.

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Staphylococcal biofilm exopolysaccharide protects against Caenorhabditis elegans immune defenses.

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Molecular pathogenesis of inflammatory bowel disease: genotypes, phenotypes and personalized medicine.

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Structural insights into the evolution of a non-biological protein: importance of surface residues in protein fold optimization.

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Zinc Finger Targeter (ZiFiT): an engineered zinc finger/target site design tool.

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Characterization of the integrated filamentous phage Pf5 and its involvement in small-colony formation.

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Profiling the DNA-binding specificities of engineered Cys2His2 zinc finger domains using a rapid cell-based method.

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General strategy for decoration of enveloped viruses with functionally active lipid-modified cytokines.

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L-arginine attenuates acute lung injury after smoke inhalation and burn injury in sheep.

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Structure and evolutionary analysis of a non-biological ATP-binding protein.

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BifA, a cyclic-Di-GMP phosphodiesterase, inversely regulates biofilm formation and swarming motility by Pseudomonas aeruginosa PA14.

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CD36 signals to the actin cytoskeleton and regulates microglial migration via a p130Cas complex.

Stuart LM, Bell SA, Stewart CR, Silver JM, Richard J, Goss JL, Tseng AA, Zhang A, El Khoury JB, Moore KJ
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Unravelling the pathogenesis of inflammatory bowel disease.

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Exploiting amoeboid and non-vertebrate animal model systems to study the virulence of human pathogenic fungi.

Mylonakis E, Casadevall A, Ausubel FM
PLoS Pathog. 2007;3(7):e101 - PMID: 17676994 - PMCID: PMC1933451

Selection and evolution of enzymes from a partially randomized non-catalytic scaffold.

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Targeting virulence: a new paradigm for antimicrobial therapy.

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Gravity force transduced by the MEC-4/MEC-10 DEG/ENaC channel modulates DAF-16/FoxO activity in Caenorhabditis elegans.

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Enzymatic synthesis of DNA on glycerol nucleic acid templates without stable duplex formation between product and template.

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Proc Natl Acad Sci U S A. 2007;104(37):14598-603 - PMID: 17785419 - PMCID: PMC1976233

AKAP13, a RhoA GTPase-specific guanine exchange factor, is a novel regulator of TLR2 signaling.

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An expanded set of amino acid analogs for the ribosomal translation of unnatural peptides.

Hartman MC, Josephson K, Lin CW, Szostak JW
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American Burn Association consensus conference to define sepsis and infection in burns.

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Inhibitors of pathogen intercellular signals as selective anti-infective compounds.

Lesic B, Lépine F, Déziel E, Zhang J, Zhang Q, Padfield K, Castonguay MH, Milot S, Stachel S, Tzika AA, Tompkins RG, Rahme LG
PLoS Pathog. 2007;3(9):1229-39 - PMID: 17941706 - PMCID: PMC2323289

DLG1 is an anchor for the E3 ligase MARCH2 at sites of cell-cell contact.

Cao Z, Huett A, Kuballa P, Giallourakis C, Xavier RJ
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Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants.

Samuelson AV, Carr CE, Ruvkun G
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A whole-genome RNAi Screen for C. elegans miRNA pathway genes.

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Continuous inertial focusing, ordering, and separation of particles in microchannels.

Di Carlo D, Irimia D, Tompkins RG, Toner M
Proc Natl Acad Sci U S A. 2007;104(48):18892-7 - PMID: 18025477 - PMCID: PMC2141878

DNA-binding specificity is a major determinant of the activity and toxicity of zinc-finger nucleases.

Cornu TI, Thibodeau-Beganny S, Guhl E, Alwin S, Eichtinger M, Joung JK, Joung JK, Cathomen T
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Molecular and functional analysis of the antigen receptor of Art v 1-specific helper T lymphocytes.

Leb VM, Jahn-Schmid B, Schmetterer KG, Kueng HJ, Haiderer D, Neunkirchner A, Fischer GF, Nissler K, Hartl A, Thalhamer J, Bohle B, Seed B, Pickl WF
J Allergy Clin Immunol. 2007;121(1):64-71 - PMID: 18037161

Miniprimer PCR, a new lens for viewing the microbial world.

Isenbarger TA, Finney M, Ríos-Velázquez C, Handelsman J, Ruvkun G
Appl Environ Microbiol. 2007;74(3):840-9 - PMID: 18083877 - PMCID: PMC2227730

Isolation of rare circulating tumour cells in cancer patients by microchip technology.

Nagrath S, Sequist LV, Maheswaran S, Bell DW, Irimia D, Ulkus L, Smith MR, Kwak EL, Digumarthy S, Muzikansky A, Ryan P, Balis UJ, Tompkins RG, Haber DA, Toner M
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Involvement of skeletal muscle gene regulatory network in susceptibility to wound infection following trauma.

Apidianakis Y, Mindrinos MN, Xiao W, Tegos GP, Papisov MI, Hamblin MR, Davis RW, Tompkins RG, Rahme LG
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Bile acids stimulate biofilm formation in Vibrio cholerae.

Hung DT, Zhu J, Sturtevant D, Mekalanos JJ
Mol Microbiol. 2006;59(1):193-201 - PMID: 16359328

Statins, cholesterol, and the prevention of coronary heart disease

MW Freeman
FASEB J. 2006;20(2):200-201

Scavenger receptors in atherosclerosis

MW Freeman and KJ Moore
Arterioscler Thromb Vasc Biol. 2006;8:1702-1711

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MW Freeman
Molecular Medicine. 2006;:ePub

A genome-wide map of diversity in Plasmodium falciparum.

Volkman SK, Sabeti PC, DeCaprio D, Neafsey DE, Schaffner SF, Milner DA, Daily JP, Sarr O, Ndiaye D, Ndir O, Mboup S, Duraisingh MT, Lukens A, Derr A, Stange-Thomann N, Waggoner S, Onofrio R, Ziaugra L, Mauceli E, Gnerre S, Jaffe DB, Zainoun J, Wiegand RC, Birren BW, Hartl DL, Galagan JE, Lander ES, Wirth DF
Nat Genet. 2006;39(1):113-9 - PMID: 17159979

Isolation and analysis of lipid rafts in cell-cell interactions.

Landry A, Xavier R
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Nore1B regulates TCR signaling via Ras and Carma1.

Ishiguro K, Avruch J, Landry A, Qin S, Ando T, Goto H, Xavier R
Cell Signal. 2006;18(10):1647-54 - PMID: 16520020 - PMCID: PMC3204664

A molecular-properties-based approach to understanding PDZ domain proteins and PDZ ligands.

Giallourakis C, Cao Z, Green T, Wachtel H, Xie X, Lopez-Illasaca M, Daly M, Rioux J, Xavier R
Genome Res. 2006;16(8):1056-72 - PMID: 16825666 - PMCID: PMC1524865

Immune cell transcriptome datasets reveal novel leukocyte subset-specific genes and genes associated with allergic processes.

Liu SM, Xavier R, Good KL, Chtanova T, Newton R, Sisavanh M, Zimmer S, Deng C, Silva DG, Frost MJ, Tangye SG, Rolph MS, Mackay CR
J Allergy Clin Immunol. 2006;118(2):496-503 - PMID: 16890777

Paeonol attenuates TNBS-induced colitis by inhibiting NF-kappaB and STAT1 transactivation.

Ishiguro K, Ando T, Maeda O, Hasegawa M, Kadomatsu K, Ohmiya N, Niwa Y, Xavier R, Goto H
Toxicol Appl Pharmacol. 2006;217(1):35-42 - PMID: 16928387

Centaurin beta1 down-regulates nucleotide-binding oligomerization domains 1- and 2-dependent NF-kappaB activation.

Yamamoto-Furusho JK, Barnich N, Xavier R, Hisamatsu T, Podolsky DK
J Biol Chem. 2006;281(47):36060-70 - PMID: 17005562

Bcl10 is phosphorylated on Ser138 by Ca2+/calmodulin-dependent protein kinase II.

Ishiguro K, Ando T, Goto H, Xavier R
Mol Immunol. 2006;44(8):2095-100 - PMID: 17052756

Vav proteins control MyD88-dependent oxidative burst.

Miletic AV, Graham DB, Montgrain V, Fujikawa K, Kloeppel T, Brim K, Weaver B, Schreiber R, Xavier R, Swat W
Blood. 2006;109(8):3360-8 - PMID: 17158234 - PMCID: PMC1852252

Vav proteins control MyD88-dependent oxidative burst.

Miletic AV, Graham DB, Montgrain V, Fujikawa K, Kloeppel T, Brim K, Weaver B, Schreiber R, Xavier R, Swat W
Blood. 2006;109(8):3360-8 - PMID: 17158234 - PMCID: PMC1852252

Ancient signals: comparative genomics of plant MAPK and MAPKK gene families.

Hamel LP, Nicole MC, Sritubtim S, Morency MJ, Ellis M, Ehlting J, Beaudoin N, Barbazuk B, Klessig D, Lee J, Martin G, Mundy J, Ohashi Y, Scheel D, Sheen J, Xing T, Zhang S, Seguin A, Ellis BE
Trends Plant Sci. 2006;11(4):192-8 - PMID: 16537113

Sugar sensing and signaling in plants: conserved and novel mechanisms.

Rolland F, Baena-Gonzalez E, Sheen J
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Specific bacterial suppressors of MAMP signaling upstream of MAPKKK in Arabidopsis innate immunity.

He P, Shan L, Lin NC, Martin GB, Kemmerling B, Nürnberger T, Sheen J
Cell. 2006;125(3):563-75 - PMID: 16678099

Regulatory functions of nuclear hexokinase1 complex in glucose signaling.

Cho YH, Yoo SD, Sheen J
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The use of protoplasts to study innate immune responses.

He P, Shan L, Sheen J
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Collectins: opsonins for apoptotic cells and regulators of inflammation.

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Clarifications on miRNA and cancer.

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Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways.

Duchaine TF, Wohlschlegel JA, Kennedy S, Bei Y, Conte D, Pang K, Brownell DR, Harding S, Mitani S, Ruvkun G, Yates JR, Mello CC
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Expression cloning screen for modifiers of amyloid precursor protein shedding.

Schöbel S, Neumann S, Seed B, Lichtenthaler SF
Int J Dev Neurosci. 2006;24(2-3):141-8 - PMID: 16446073

Statins, cholesterol, and the prevention of coronary heart disease.

Freeman MW
FASEB J. 2006;20(2):200-1 - PMID: 16449790

Polygenic control of Caenorhabditis elegans fat storage.

Mak HY, Nelson LS, Basson M, Johnson CD, Ruvkun G
Nat Genet. 2006;38(3):363-8 - PMID: 16462744

An ordered, nonredundant library of Pseudomonas aeruginosa strain PA14 transposon insertion mutants.

Liberati NT, Urbach JM, Miyata S, Lee DG, Drenkard E, Wu G, Villanueva J, Wei T, Ausubel FM
Proc Natl Acad Sci U S A. 2006;103(8):2833-8 - PMID: 16477005 - PMCID: PMC1413827

Analysis of Pseudomonas aeruginosa diguanylate cyclases and phosphodiesterases reveals a role for bis-(3'-5')-cyclic-GMP in virulence.

Kulasakara H, Lee V, Brencic A, Liberati N, Urbach J, Miyata S, Lee DG, Neely AN, Hyodo M, Hayakawa Y, Ausubel FM, Lory S
Proc Natl Acad Sci U S A. 2006;103(8):2839-44 - PMID: 16477007 - PMCID: PMC1413825

Directed evolution of ATP binding proteins from a zinc finger domain by using mRNA display.

Cho GS, Szostak JW
Chem Biol. 2006;13(2):139-47 - PMID: 16492562

Solution structure of an informationally complex high-affinity RNA aptamer to GTP.

Carothers JM, Davis JH, Chou JJ, Szostak JW
RNA. 2006;12(4):567-79 - PMID: 16510427 - PMCID: PMC1421093

Counter-selectable marker for bacterial-based interaction trap systems.

Meng X, Smith RM, Giesecke AV, Joung JK, Wolfe SA
Biotechniques. 2006;40(2):179-84 - PMID: 16526407

Enzymatic aminoacylation of tRNA with unnatural amino acids.

Hartman MC, Josephson K, Szostak JW
Proc Natl Acad Sci U S A. 2006;103(12):4356-61 - PMID: 16537388 - PMCID: PMC1450175

Nonmetabolizable glucose compounds impart cryotolerance to primary rat hepatocytes.

Sugimachi K, Roach KL, Rhoads DB, Tompkins RG, Toner M
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A genetic interaction between the vesicular acetylcholine transporter VAChT/UNC-17 and synaptobrevin/SNB-1 in C. elegans.

Sandoval GM, Duerr JS, Hodgkin J, Rand JB, Ruvkun G
Nat Neurosci. 2006;9(5):599-601 - PMID: 16604067

Adipocyte apoptosis after burn injury is associated with altered fat metabolism.

Yasuhara S, Kaneki M, Sugita H, Sugita M, Asai A, Sahani N, Chon JY, Tompkins RG, Martyn JA
J Burn Care Res. 2006;27(3):367-76 - PMID: 16679908

High dynamic range characterization of the trauma patient plasma proteome.

Liu T, Qian WJ, Gritsenko MA, Xiao W, Moldawer LL, Kaushal A, Monroe ME, Varnum SM, Moore RJ, Purvine SO, Maier RV, Davis RW, Tompkins RG, Camp DG, Smith RD,
Mol Cell Proteomics. 2006;5(10):1899-913 - PMID: 16684767 - PMCID: PMC1783978

Scavenger receptors in atherosclerosis: beyond lipid uptake.

Moore KJ, Freeman MW
Arterioscler Thromb Vasc Biol. 2006;26(8):1702-11 - PMID: 16728653

Synthetic protein-protein interaction domains created by shuffling Cys2His2 zinc-fingers.

Giesecke AV, Fang R, Joung JK
Mol Syst Biol. 2006;2:2006.2011 - PMID: 16732192 - PMCID: PMC1681485

Ribosomal synthesis of dehydroalanine-containing peptides.

Seebeck FP, Szostak JW
J Am Chem Soc. 2006;128(22):7150-1 - PMID: 16734454 - PMCID: PMC2572134

Prevention and control of pests and diseases.

Bush J, Jander G, Ausubel FM
Methods Mol Biol. 2006;323:13-25 - PMID: 16739564

CARMA1 is critical for the development of allergic airway inflammation in a murine model of asthma.

Medoff BD, Seed B, Jackobek R, Zora J, Yang Y, Luster AD, Xavier R
J Immunol. 2006;176(12):7272-7 - PMID: 16751370

Negative chemical ionization gas chromatography/mass spectrometry to quantify urinary 3-methylhistidine: application to burn injury.

Beffa DC, Carter EA, Lu XM, Yu YM, Prelack K, Sheridan RL, Young VR, Fischman AJ, Tompkins RG
Anal Biochem. 2006;355(1):95-101 - PMID: 16762308

SLIRP, a small SRA binding protein, is a nuclear receptor corepressor.

Hatchell EC, Colley SM, Beveridge DJ, Epis MR, Stuart LM, Giles KM, Redfern AD, Miles LE, Barker A, MacDonald LM, Arthur PG, Lui JC, Golding JL, McCulloch RK, Metcalf CB, Wilce JA, Wilce MC, Lanz RB, O'Malley BW, Leedman PJ
Mol Cell. 2006;22(5):657-68 - PMID: 16762838

Aptamers selected for higher-affinity binding are not more specific for the target ligand.

Carothers JM, Oestreich SC, Szostak JW
J Am Chem Soc. 2006;128(24):7929-37 - PMID: 16771507 - PMCID: PMC4287982

Treatment of fulminant hepatic failure in rats using a bioartificial liver device containing porcine hepatocytes producing interleukin-1 receptor antagonist.

Shinoda M, Tilles AW, Wakabayashi G, Takayanagi A, Harada H, Obara H, Suganuma K, Berthiaume F, Shimazu M, Shimizu N, Kitajima M, Tompkins RG, Toner M, Yarmush ML
Tissue Eng. 2006;12(5):1313-23 - PMID: 16771644 - PMCID: PMC3202215

Identification of novel antimicrobials using a live-animal infection model.

Moy TI, Ball AR, Anklesaria Z, Casadei G, Lewis K, Ausubel FM
Proc Natl Acad Sci U S A. 2006;103(27):10414-9 - PMID: 16801562 - PMCID: PMC1482800

Ca2+/calmodulin-dependent protein kinase II is a modulator of CARMA1-mediated NF-kappaB activation.

Ishiguro K, Green T, Rapley J, Wachtel H, Giallourakis C, Landry A, Cao Z, Lu N, Takafumi A, Goto H, Daly MJ, Xavier RJ
Mol Cell Biol. 2006;26(14):5497-508 - PMID: 16809782 - PMCID: PMC1592706

Chemical biology and bacteria: not simply a matter of life or death.

Hung DT, Rubin EJ
Curr Opin Chem Biol. 2006;10(4):321-6 - PMID: 16814591

Inflammation and the host response to injury: an overview of the multicenter study of the genomic and proteomic response to burn injury.

Klein MB, Silver G, Gamelli RL, Gibran NS, Herndon DN, Hunt JL, Tompkins RG,
J Burn Care Res. 2006;27(4):448-51 - PMID: 16819346

Panning of multiple subsets of leukocytes on antibody-decorated poly(ethylene) glycol-coated glass slides.

Sekine K, Revzin A, Tompkins RG, Toner M
J Immunol Methods. 2006;313(1-2):96-109 - PMID: 16822521

A sequence-oriented comparison of gene expression measurements across different hybridization-based technologies.

Kuo WP, Liu F, Trimarchi J, Punzo C, Lombardi M, Sarang J, Whipple ME, Maysuria M, Serikawa K, Lee SY, McCrann D, Kang J, Shearstone JR, Burke J, Park DJ, Wang X, Rector TL, Ricciardi-Castagnoli P, Perrin S, Choi S, Bumgarner R, Kim JH, Short GF, Freeman MW, Seed B, Jensen R, Church GM, Hovig E, Cepko CL, Park P, Ohno-Machado L, Jenssen TK
Nat Biotechnol. 2006;24(7):832-40 - PMID: 16823376

Putting food on the public health table: Making food security relevant to regional health authorities.

Rideout K, Seed B, Ostry A
Can J Public Health. 2006;97(3):233-6 - PMID: 16827415

Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling.

Hu PJ, Xu J, Ruvkun G
PLoS Genet. 2006;2(7):e99 - PMID: 16839187 - PMCID: PMC1487177

Microfluidic isolation of leukocytes from whole blood for phenotype and gene expression analysis.

Sethu P, Moldawer LL, Mindrinos MN, Scumpia PO, Tannahill CL, Wilhelmy J, Efron PA, Brownstein BH, Tompkins RG, Toner M
Anal Chem. 2006;78(15):5453-61 - PMID: 16878882

Peroxidase-dependent apoplastic oxidative burst in Arabidopsis required for pathogen resistance.

Bindschedler LV, Dewdney J, Blee KA, Stone JM, Asai T, Plotnikov J, Denoux C, Hayes T, Gerrish C, Davies DR, Ausubel FM, Bolwell GP
Plant J. 2006;47(6):851-63 - PMID: 16889645 - PMCID: PMC3233234

Mineral surface directed membrane assembly.

Hanczyc MM, Mansy SS, Szostak JW
Orig Life Evol Biosph. 2006;37(1):67-82 - PMID: 16909329

Local and distant burn injury alter immuno-inflammatory gene expression in skeletal muscle.

Padfield KE, Zhang Q, Gopalan S, Tzika AA, Mindrinos MN, Tompkins RG, Rahme LG
J Trauma. 2006;61(2):280-92 - PMID: 16917440

Direct stimulation of T lymphocytes by immunosomes: virus-like particles decorated with T cell receptor/CD3 ligands plus costimulatory molecules.

Derdak SV, Kueng HJ, Leb VM, Neunkirchner A, Schmetterer KG, Bielek E, Majdic O, Knapp W, Seed B, Pickl WF
Proc Natl Acad Sci U S A. 2006;103(35):13144-9 - PMID: 16924110 - PMCID: PMC1559767

Requirements for apoptotic cell contact in regulation of macrophage responses.

Lucas M, Stuart LM, Zhang A, Hodivala-Dilke K, Febbraio M, Silverstein R, Savill J, Lacy-Hulbert A
J Immunol. 2006;177(6):4047-54 - PMID: 16951368

A genomewide search for ribozymes reveals an HDV-like sequence in the human CPEB3 gene.

Salehi-Ashtiani K, Lupták A, Litovchick A, Szostak JW
Science. 2006;313(5794):1788-92 - PMID: 16990549

Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging.

Blackburn EH, Greider CW, Szostak JW
Nat Med. 2006;12(10):1133-8 - PMID: 17024208

Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways.

Laudanski K, Miller-Graziano C, Xiao W, Mindrinos MN, Richards DR, De A, Moldawer LL, Maier RV, Bankey P, Baker HV, Brownstein BH, Cobb JP, Calvano SE, Davis RW, Tompkins RG
Proc Natl Acad Sci U S A. 2006;103(42):15564-9 - PMID: 17032758 - PMCID: PMC1592643

Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorial.

Lee DG, Urbach JM, Wu G, Liberati NT, Feinbaum RL, Miyata S, Diggins LT, He J, Saucier M, Déziel E, Friedman L, Li L, Grills G, Montgomery K, Kucherlapati R, Rahme LG, Ausubel FM
Genome Biol. 2006;7(10):R90 - PMID: 17038190 - PMCID: PMC1794565

Detection of broadly expressed neuronal genes in C. elegans.

Ruvinsky I, Ohler U, Burge CB, Ruvkun G
Dev Biol. 2006;302(2):617-26 - PMID: 17046742

The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25.

Hayes GD, Frand AR, Ruvkun G
Development. 2006;133(23):4631-41 - PMID: 17065234

Glycerol nucleoside triphosphates: synthesis and polymerase substrate activities.

Horhota AT, Szostak JW, McLaughlin LW
Org Lett. 2006;8(23):5345-7 - PMID: 17078714

A bioartificial liver device secreting interleukin-1 receptor antagonist for the treatment of hepatic failure in rats.

Shinoda M, Tilles AW, Kobayashi N, Wakabayashi G, Takayanagi A, Totsugawa T, Harada H, Obara H, Suganuma K, Berthiaume F, Shimazu M, Shimizu N, Tanaka N, Kitajima M, Tompkins RG, Toner M, Yarmush ML
J Surg Res. 2006;137(1):130-40 - PMID: 17081566 - PMCID: PMC3201777

Uncoupling protein 3 expression and intramyocellular lipid accumulation by NMR following local burn trauma.

Zhang Q, Cao H, Astrakas LG, Mintzopoulos D, Mindrinos MN, Schulz J, Tompkins RG, Rahme LG, Tzika AA
Int J Mol Med. 2006;18(6):1223-9 - PMID: 17089030

p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans.

Troemel ER, Chu SW, Reinke V, Lee SS, Ausubel FM, Kim DH
PLoS Genet. 2006;2(11):e183 - PMID: 17096597 - PMCID: PMC1635533

ABCA3 inactivation in mice causes respiratory failure, loss of pulmonary surfactant, and depletion of lung phosphatidylglycerol.

Fitzgerald ML, Xavier R, Haley KJ, Welti R, Goss JL, Brown CE, Zhuang DZ, Bell SA, Lu N, McKee M, Seed B, Freeman MW
J Lipid Res. 2006;48(3):621-32 - PMID: 17142808

A systems biology analysis of the Drosophila phagosome.

Stuart LM, Boulais J, Charriere GM, Hennessy EJ, Brunet S, Jutras I, Goyette G, Rondeau C, Letarte S, Huang H, Ye P, Morales F, Kocks C, Bader JS, Desjardins M, Ezekowitz RA
Nature. 2006;445(7123):95-101 - PMID: 17151602

Prospects for plant-derived antibacterials.

Lewis K, Ausubel FM
Nat Biotechnol. 2006;24(12):1504-7 - PMID: 17160050

Conjugating berberine to a multidrug efflux pump inhibitor creates an effective antimicrobial.

Ball AR, Casadei G, Samosorn S, Bremner JB, Ausubel FM, Moy TI, Lewis K
ACS Chem Biol. 2006;1(9):594-600 - PMID: 17168555

Discs-large homolog 1 regulates smooth muscle orientation in the mouse ureter.

Mahoney ZX, Sammut B, Xavier RJ, Cunningham J, Go G, Brim KL, Stappenbeck TS, Miner JH, Swat W
Proc Natl Acad Sci U S A. 2006;103(52):19872-7 - PMID: 17172448 - PMCID: PMC1750896

Risk factors for coronary artery disease in patients with elevated high-density lipoprotein cholesterol.

DeFaria Yeh D, Freeman MW, Meigs JB, Grant RW
Am J Cardiol. 2006;99(1):1-4 - PMID: 17196452

A microfluidic device for practical label-free CD4(+) T cell counting of HIV-infected subjects.

Cheng X, Irimia D, Dixon M, Sekine K, Demirci U, Zamir L, Tompkins RG, Rodriguez W, Toner M
Lab Chip. 2006;7(2):170-8 - PMID: 17268618 - PMCID: PMC4028372

Cryopreservation of isolated primary rat hepatocytes: enhanced survival and long-term hepatospecific function.

Sosef MN, Baust JM, Sugimachi K, Fowler A, Tompkins RG, Toner M
Ann Surg. 2005;241(1):125-33 - PMID: 15622000 - PMCID: PMC1356855

Evolution of intrahepatic carbon, nitrogen, and energy metabolism in a D-galactosamine-induced rat liver failure model.

Yokoyama T, Banta S, Berthiaume F, Nagrath D, Tompkins RG, Yarmush ML
Metab Eng. 2005;7(2):88-103 - PMID: 15781418

Burn injury causes mitochondrial dysfunction in skeletal muscle.

Padfield KE, Astrakas LG, Zhang Q, Gopalan S, Dai G, Mindrinos MN, Tompkins RG, Rahme LG, Tzika AA
Proc Natl Acad Sci U S A. 2005;102(15):5368-73 - PMID: 15809440 - PMCID: PMC556259

Proton NMR spectroscopy shows lipids accumulate in skeletal muscle in response to burn trauma-induced apoptosis.

Astrakas LG, Goljer I, Yasuhara S, Padfield KE, Zhang Q, Gopalan S, Mindrinos MN, Dai G, Yu YM, Martyn JA, Tompkins RG, Rahme LG, Tzika AA
FASEB J. 2005;19(11):1431-40 - PMID: 16126910

Molecular mechanism(s) of burn-induced insulin resistance in murine skeletal muscle: role of IRS phosphorylation.

Zhang Q, Carter EA, Ma BY, White M, Fischman AJ, Tompkins RG
Life Sci. 2005;77(24):3068-77 - PMID: 15982669

A network-based analysis of systemic inflammation in humans.

Calvano SE, Xiao W, Richards DR, Felciano RM, Baker HV, Cho RJ, Chen RO, Brownstein BH, Cobb JP, Tschoeke SK, Miller-Graziano C, Moldawer LL, Mindrinos MN, Davis RW, Tompkins RG, Lowry SF,
Nature. 2005;437(7061):1032-7 - PMID: 16136080

Application of genome-wide expression analysis to human health and disease.

Cobb JP, Mindrinos MN, Miller-Graziano C, Calvano SE, Baker HV, Xiao W, Laudanski K, Brownstein BH, Elson CM, Hayden DL, Herndon DN, Lowry SF, Maier RV, Schoenfeld DA, Moldawer LL, Davis RW, Tompkins RG, Baker HV, Bankey P, Billiar T, Brownstein BH, Calvano SE, Camp D, Chaudry I, Cobb JP, Davis RW, Elson CM, Freeman B, Gamelli R, Gibran N, Harbrecht B, Hayden DL, Heagy W, Heimbach D, Herndon DN, Horton J, Hunt J, Laudanski K, Lederer J, Lowry SF, Maier RV, Mannick J, McKinley B, Miller-Grazi ...
Proc Natl Acad Sci U S A. 2005;102(13):4801-6 - PMID: 15781863 - PMCID: PMC555033

A new approach for sequencing human IRS1 phosphotyrosine-containing peptides using CapLC-Q-TOF(micro).

Lu XM, Lu MY, Fischman AJ, Tompkins RG
J Mass Spectrom. 2005;40(5):599-607 - PMID: 15739155

Enrichment using antibody-coated microfluidic chambers in shear flow: model mixtures of human lymphocytes.

Sin A, Murthy SK, Revzin A, Tompkins RG, Toner M
Biotechnol Bioeng. 2005;91(7):816-26 - PMID: 16037988

Selective activation of peripheral blood T cell subsets by endotoxin infusion in healthy human subjects corresponds to differential chemokine activation.

De AK, Miller-Graziano CL, Calvano SE, Laudanski K, Lowry SF, Moldawer LL, Remick DG, Rajicic N, Schoenfeld D, Tompkins RG
J Immunol. 2005;175(9):6155-62 - PMID: 16237112

Site-specific detection of S-nitrosylated PKB alpha/Akt1 from rat soleus muscle using CapLC-Q-TOF(micro) mass spectrometry.

Lu XM, Lu M, Tompkins RG, Fischman AJ
J Mass Spectrom. 2005;40(9):1140-8 - PMID: 16041729

Quantitative proteome analysis of human plasma following in vivo lipopolysaccharide administration using 16O/18O labeling and the accurate mass and time tag approach.

Qian WJ, Monroe ME, Liu T, Jacobs JM, Anderson GA, Shen Y, Moore RJ, Anderson DJ, Zhang R, Calvano SE, Lowry SF, Xiao W, Moldawer LL, Davis RW, Tompkins RG, Camp DG, Smith RD,
Mol Cell Proteomics. 2005;4(5):700-9 - PMID: 15753121 - PMCID: PMC1829297

Comparative proteome analyses of human plasma following in vivo lipopolysaccharide administration using multidimensional separations coupled with tandem mass spectrometry.

Qian WJ, Jacobs JM, Camp DG, Monroe ME, Moore RJ, Gritsenko MA, Calvano SE, Lowry SF, Xiao W, Moldawer LL, Davis RW, Tompkins RG, Smith RD
Proteomics. 2005;5(2):572-84 - PMID: 15627965 - PMCID: PMC1781926

Significance analysis of time course microarray experiments.

Storey JD, Xiao W, Leek JT, Tompkins RG, Davis RW
Proc Natl Acad Sci U S A. 2005;102(36):12837-42 - PMID: 16141318 - PMCID: PMC1201697

The worm has turned--microbial virulence modeled in Caenorhabditis elegans.

Sifri CD, Begun J, Ausubel FM
Trends Microbiol. 2005;13(3):119-27 - PMID: 15737730

Galleria mellonella as a model system to study Cryptococcus neoformans pathogenesis.

Mylonakis E, Moreno R, El Khoury JB, Idnurm A, Heitman J, Calderwood SB, Ausubel FM, Diener A
Infect Immun. 2005;73(7):3842-50 - PMID: 15972469 - PMCID: PMC1168598

RESISTANCE TO FUSARIUM OXYSPORUM 1, a dominant Arabidopsis disease-resistance gene, is not race specific.

Diener AC, Ausubel FM
Genetics. 2005;171(1):305-21 - PMID: 15965251 - PMCID: PMC1456520

Pseudomonas syringae manipulates systemic plant defenses against pathogens and herbivores.

Cui J, Bahrami AK, Pringle EG, Hernandez-Guzman G, Bender CL, Pierce NE, Ausubel FM
Proc Natl Acad Sci U S A. 2005;102(5):1791-6 - PMID: 15657122 - PMCID: PMC547856

Evolutionary perspectives on innate immunity from the study of Caenorhabditis elegans.

Kim DH, Ausubel FM
Curr Opin Immunol. 2005;17(1):4-10 - PMID: 15653303

Mediation of pathogen resistance by exudation of antimicrobials from roots.

Bais HP, Prithiviraj B, Jha AK, Ausubel FM, Vivanco JM
Nature. 2005;434(7030):217-21 - PMID: 15759001

Are innate immune signaling pathways in plants and animals conserved?

Ausubel FM
Nat Immunol. 2005;6(10):973-9 - PMID: 16177805

A high-throughput, near-saturating screen for type III effector genes from Pseudomonas syringae.

Chang JH, Urbach JM, Law TF, Arnold LW, Hu A, Gombar S, Grant SR, Ausubel FM, Dangl JL
Proc Natl Acad Sci U S A. 2005;102(7):2549-54 - PMID: 15701698 - PMCID: PMC549004

Staphylococcus aureus virulence factors identified by using a high-throughput Caenorhabditis elegans-killing model.

Begun J, Sifri CD, Goldman S, Calderwood SB, Ausubel FM
Infect Immun. 2005;73(2):872-7 - PMID: 15664928 - PMCID: PMC547013

Scanning the human proteome for calmodulin-binding proteins.

Shen X, Valencia CA, Szostak JW, Szostak J, Dong B, Liu R
Proc Natl Acad Sci U S A. 2005;102(17):5969-74 - PMID: 15840729 - PMCID: PMC1087907

RNA catalysis in model protocell vesicles.

Chen IA, Salehi-Ashtiani K, Szostak JW
J Am Chem Soc. 2005;127(38):13213-9 - PMID: 16173749 - PMCID: PMC5072289

An in vitro selection system for TNA.

Ichida JK, Zou K, Horhota A, Yu B, McLaughlin LW, Szostak JW
J Am Chem Soc. 2005;127(9):2802-3 - PMID: 15740086 - PMCID: PMC5072288

Kinetic analysis of an efficient DNA-dependent TNA polymerase.

Horhota A, Zou K, Ichida JK, Yu B, McLaughlin LW, Szostak JW, Chaput JC
J Am Chem Soc. 2005;127(20):7427-34 - PMID: 15898792 - PMCID: PMC5042361

In vitro selection of RNA aptamers against a composite small molecule-protein surface.

Plummer KA, Carothers JM, Yoshimura M, Szostak JW, Verdine GL
Nucleic Acids Res. 2005;33(17):5602-10 - PMID: 16199752 - PMCID: PMC1240114

Semipermeable lipid bilayers exhibit diastereoselectivity favoring ribose.

Sacerdote MG, Szostak JW
Proc Natl Acad Sci U S A. 2005;102(17):6004-8 - PMID: 15831588 - PMCID: PMC556129

High fidelity TNA synthesis by Therminator polymerase.

Ichida JK, Horhota A, Zou K, McLaughlin LW, Szostak JW
Nucleic Acids Res. 2005;33(16):5219-25 - PMID: 16157867 - PMCID: PMC1214552

Shrink-wrap vesicles.

Fujikawa SM, Chen IA, Szostak JW
Langmuir. 2005;21(26):12124-9 - PMID: 16342983 - PMCID: PMC2548281

Synthesis of alpha-L-threofuranosyl nucleoside triphosphates (tNTPs).

Zou K, Horhota A, Yu B, Szostak JW, McLaughlin LW
Org Lett. 2005;7(8):1485-7 - PMID: 15816733 - PMCID: PMC5022784

Ribosomal synthesis of unnatural peptides.

Josephson K, Hartman MC, Szostak JW
J Am Chem Soc. 2005;127(33):11727-35 - PMID: 16104750

Phagocytosis: elegant complexity.

Stuart LM, Ezekowitz RA
Immunity. 2005;22(5):539-50 - PMID: 15894272

Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila.

Kocks C, Cho JH, Nehme N, Ulvila J, Pearson AM, Meister M, Strom C, Conto SL, Hetru C, Stuart LM, Stehle T, Hoffmann JA, Reichhart JM, Ferrandon D, Rämet M, Ezekowitz RA
Cell. 2005;123(2):335-46 - PMID: 16239149

Mannose-binding lectin-deficient mice display defective apoptotic cell clearance but no autoimmune phenotype.

Stuart LM, Takahashi K, Shi L, Savill J, Ezekowitz RA
J Immunol. 2005;174(6):3220-6 - PMID: 15749852

Response to Staphylococcus aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain.

Stuart LM, Deng J, Silver JM, Takahashi K, Tseng AA, Hennessy EJ, Ezekowitz RA, Moore KJ
J Cell Biol. 2005;170(3):477-85 - PMID: 16061696 - PMCID: PMC2171464

Repression of phase-variable cup gene expression by H-NS-like proteins in Pseudomonas aeruginosa.

Vallet-Gely I, Donovan KE, Fang R, Joung JK, Dove SL
Proc Natl Acad Sci U S A. 2005;102(31):11082-7 - PMID: 16043713 - PMCID: PMC1182424

A combined yeast/bacteria two-hybrid system: development and evaluation.

Serebriiskii IG, Fang R, Latypova E, Hopkins R, Vinson C, Joung JK, Golemis EA
Mol Cell Proteomics. 2005;4(6):819-26 - PMID: 15781424 - PMCID: PMC2670611

Bile acids induce cholera toxin expression in Vibrio cholerae in a ToxT-independent manner.

Hung DT, Mekalanos JJ
Proc Natl Acad Sci U S A. 2005;102(8):3028-33 - PMID: 15699331 - PMCID: PMC549475

Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization.

Hung DT, Shakhnovich EA, Pierson E, Mekalanos JJ
Science. 2005;310(5748):670-4 - PMID: 16223984

Identification of eosinophil lineage-committed progenitors in the murine bone marrow.

Iwasaki H, Mizuno S, Mayfield R, Shigematsu H, Arinobu Y, Seed B, Gurish MF, Takatsu K, Akashi K
J Exp Med. 2005;201(12):1891-7 - PMID: 15955840 - PMCID: PMC2212039

B cell maturation antigen, the receptor for a proliferation-inducing ligand and B cell-activating factor of the TNF family, induces antigen presentation in B cells.

Yang M, Hase H, Legarda-Addison D, Varughese L, Seed B, Ting AT
J Immunol. 2005;175(5):2814-24 - PMID: 16116167

Atherosclerosis and innate immunity signaling

Laberge MA, Moore KJ, and MW Freeman.
Annals of Medicine. 2005;37:130-140

Tangier Disease and Neuropathy. In: Dyck, PJ and Thomas, PK, Eds

Gilmore O’Neill and MW Freeman
Peripheral Neuropathy 4th edition. 2005;:ePub

Approach to the patient with hypercholesterolemia. In: Goroll A, May L, Mulley A, eds

MW Freeman
Primary Care Medicine, 5th Edition. 2005;:ePub

What to do about high cholesterol

M Freeman, Consultant editor 3rd edition Junge C, Skerret PJ, and Emond, SD.
President and Fellows of Harvard College. Harvard Health Publications. 2005;:ePub

Distinct roles of pattern recognition receptors CD14 and Toll-like receptor 4 in acute lung injury.

Jeyaseelan S, Chu HW, Young SK, Freeman MW, Worthen GS
Infect Immun. 2005;73(3):1754-63 - PMID: 15731076 - PMCID: PMC1064978

Efficacy and safety of the coadministration of ezetimibe with fenofibrate in patients with mixed hyperlipidaemia.

Farnier M, Freeman MW, Macdonell G, Perevozskaya I, Davies MJ, Mitchel YB, Gumbiner B,
Eur Heart J. 2005;26(9):897-905 - PMID: 15781429

Atherosclerosis and innate immune signaling.

Laberge MA, Moore KJ, Freeman MW
Ann Med. 2005;37(2):130-40 - PMID: 16026120

Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment.

Heller EA, Liu E, Tager AM, Sinha S, Roberts JD, Koehn SL, Libby P, Aikawa ER, Chen JQ, Huang P, Freeman MW, Moore KJ, Luster AD, Gerszten RE
Circulation. 2005;112(4):578-86 - PMID: 16043658

Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice.

Moore KJ, Kunjathoor VV, Koehn SL, Manning JJ, Tseng AA, Silver JM, McKee M, Freeman MW
J Clin Invest. 2005;115(8):2192-201 - PMID: 16075060 - PMCID: PMC1180534

Nonparametric methods for microarray data based on exchangeability and borrowed power.

Lee ML, Whitmore GA, Björkbacka H, Freeman MW
J Biopharm Stat. 2005;15(5):783-97 - PMID: 16078385

Purification of ATP-binding cassette transporter A1 and associated binding proteins reveals the importance of beta1-syntrophin in cholesterol efflux.

Okuhira K, Fitzgerald ML, Sarracino DA, Manning JJ, Bell SA, Goss JL, Freeman MW
J Biol Chem. 2005;280(47):39653-64 - PMID: 16192269

Assembly of polymorphic genomes: algorithms and application to Ciona savignyi.

Vinson JP, Jaffe DB, O'Neill K, Karlsson EK, Stange-Thomann N, Anderson S, Mesirov JP, Satoh N, Satou Y, Nusbaum C, Birren B, Galagan JE, Lander ES
Genome Res. 2005;15(8):1127-35 - PMID: 16077012 - PMCID: PMC1182225

Genome sequence, comparative analysis and haplotype structure of the domestic dog.

Lindblad-Toh K, Wade CM, Mikkelsen TS, Karlsson EK, Jaffe DB, Kamal M, Clamp M, Chang JL, Kulbokas EJ, Zody MC, Mauceli E, Xie X, Breen M, Wayne RK, Ostrander EA, Ponting CP, Galibert F, Smith DR, DeJong PJ, Kirkness E, Alvarez P, Biagi T, Brockman W, Butler J, Chin CW, Cook A, Cuff J, Daly MJ, DeCaprio D, Gnerre S, Grabherr M, Kellis M, Kleber M, Bardeleben C, Goodstadt L, Heger A, Hitte C, Kim L, Koepfli KP, Parker HG, Pollinger JP, Searle SM, Sutter NB, Thomas R, Webber C, Baldwin J, Abeb ...
Nature. 2005;438(7069):803-19 - PMID: 16341006

Functional genomic analysis of RNA interference in C. elegans.

Kim JK, Gabel HW, Kamath RS, Tewari M, Pasquinelli A, Rual JF, Kennedy S, Dybbs M, Bertin N, Kaplan JM, Vidal M, Ruvkun G
Science. 2005;308(5725):1164-7 - PMID: 15790806

Analysis of xbx genes in C. elegans.

Efimenko E, Bubb K, Mak HY, Holzman T, Leroux MR, Ruvkun G, Thomas JH, Swoboda P
Development. 2005;132(8):1923-34 - PMID: 15790967

The tiny RNA world.

Ruvkun GB
Harvey Lect. 2005;99:1-21 - PMID: 15984549

A systematic RNAi screen for longevity genes in C. elegans.

Hamilton B, Dong Y, Shindo M, Liu W, Odell I, Ruvkun G, Lee SS
Genes Dev. 2005;19(13):1544-55 - PMID: 15998808 - PMCID: PMC1172061

Systematic analysis of genes required for synapse structure and function.

Sieburth D, Ch'ng Q, Dybbs M, Tavazoie M, Kennedy S, Wang D, Dupuy D, Rual JF, Hill DE, Vidal M, Ruvkun G, Kaplan JM
Nature. 2005;436(7050):510-7 - PMID: 16049479

Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants.

Wang D, Kennedy S, Conte D, Kim JK, Gabel HW, Kamath RS, Mello CC, Ruvkun G
Nature. 2005;436(7050):593-7 - PMID: 16049496

Regulation of Caenorhabditis elegans RNA interference by the daf-2 insulin stress and longevity signaling pathway.

Wang D, Ruvkun G
Cold Spring Harb Symp Quant Biol. 2005;69:429-31 - PMID: 16117677

Functional genomic analysis of C. elegans molting.

Frand AR, Russel S, Ruvkun G
PLoS Biol. 2005;3(10):e312 - PMID: 16122351 - PMCID: PMC1233573

Large-scale screens for cDNAs with in vivo activity.

Ting A, Lichtenthaler S, Xavier R, Na SY, Rabizadeh S, Holmes T, Seed B
Novartis Found Symp. 2005;267:219-29; discussion 229-30 - PMID: 15999809

Commensal flora: wolf in sheep's clothing.

Xavier R, Podolsky DK
Gastroenterology. 2005;128(4):1122-6 - PMID: 15825094

PDZ domains and the politics of polarity in lymphocytes.

Xavier R, Seed B
Immunity. 2005;22(6):655-6 - PMID: 15963778

Bioluminescence resonance energy transfer identify scaffold protein CNK1 interactions in intact cells.

Lopez-Ilasaca MA, Bernabe-Ortiz JC, Na SY, Dzau VJ, Xavier RJ
FEBS Lett. 2005;579(3):648-54 - PMID: 15670823

GRIM-19 interacts with nucleotide oligomerization domain 2 and serves as downstream effector of anti-bacterial function in intestinal epithelial cells.

Barnich N, Hisamatsu T, Aguirre JE, Xavier R, Reinecker HC, Podolsky DK
J Biol Chem. 2005;280(19):19021-6 - PMID: 15753091

Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognition.

Barnich N, Aguirre JE, Reinecker HC, Xavier R, Podolsky DK
J Cell Biol. 2005;170(1):21-6 - PMID: 15998797 - PMCID: PMC2171381

Sugar sensing and signalling networks in plants.

Rolland F, Sheen J
Biochem Soc Trans. 2005;33(Pt 1):269-71 - PMID: 15667323

Generalized rank tests for replicated microarray data.

Lee ML, Gray RJ, Björkbacka H, Freeman MW
Stat Appl Genet Mol Biol. 2005;4:Article3 - PMID: 16646848

Harvard Medical School Guide to Lowering your Cholesterol

MW Freeman and Christine Junge
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Technique for expanding the donor liver pool: heat shock preconditioning in a rat fatty liver model.

Mokuno Y, Berthiaume F, Tompkins RG, Balis UJ, Yarmush ML
Liver Transpl. 2004;10(2):264-72 - PMID: 14762865

Short-term enteral glutamine does not enhance protein accretion in burned children: a stable isotope study.

Sheridan RL, Prelack K, Yu YM, Lydon M, Petras L, Young VR, Tompkins RG
Surgery. 2004;135(6):671-8 - PMID: 15179374

Analysis of Pseudomonas aeruginosa 4-hydroxy-2-alkylquinolines (HAQs) reveals a role for 4-hydroxy-2-heptylquinoline in cell-to-cell communication.

Déziel E, Lépine F, Milot S, He J, Mindrinos MN, Tompkins RG, Rahme LG
Proc Natl Acad Sci U S A. 2004;101(5):1339-44 - PMID: 14739337 - PMCID: PMC337054

Insulin resistance in thermally-injured rats is associated with post-receptor alterations in skeletal muscle, liver and adipose tissue.

Carter EA, Burks D, Fischman AJ, White M, Tompkins RG
Int J Mol Med. 2004;14(4):653-8 - PMID: 15375597

Support of the metabolic response to burn injury.

Herndon DN, Tompkins RG
Lancet. 2004;363(9424):1895-902 - PMID: 15183630

Whole blood and leukocyte RNA isolation for gene expression analyses.

Feezor RJ, Baker HV, Mindrinos M, Hayden D, Tannahill CL, Brownstein BH, Fay A, MacMillan S, Laramie J, Xiao W, Moldawer LL, Cobb JP, Laudanski K, Miller-Graziano CL, Maier RV, Schoenfeld D, Davis RW, Tompkins RG,
Physiol Genomics. 2004;19(3):247-54 - PMID: 15548831

Development of a microfabricated cytometry platform for characterization and sorting of individual leukocytes.

Revzin A, Sekine K, Sin A, Tompkins RG, Toner M
Lab Chip. 2004;5(1):30-7 - PMID: 15616737

Continuous flow microfluidic device for rapid erythrocyte lysis.

Sethu P, Anahtar M, Moldawer LL, Tompkins RG, Toner M
Anal Chem. 2004;76(21):6247-53 - PMID: 15516115

Single-cell chemical lysis in picoliter-scale closed volumes using a microfabricated device.

Irimia D, Tompkins RG, Toner M
Anal Chem. 2004;76(20):6137-43 - PMID: 15481964

Effect of flow and surface conditions on human lymphocyte isolation using microfluidic chambers.

Murthy SK, Sin A, Tompkins RG, Toner M
Langmuir. 2004;20(26):11649-55 - PMID: 15595794

What's new in burns and metabolism.

Sheridan RL, Tompkins RG
J Am Coll Surg. 2004;198(2):243-63 - PMID: 14759783

Long-term function of cryopreserved rat hepatocytes in a coculture system.

Sugimachi K, Sosef MN, Baust JM, Fowler A, Tompkins RG, Toner M
Cell Transplant. 2004;13(2):187-95 - PMID: 15129765

Ultra-high-efficiency strong cation exchange LC/RPLC/MS/MS for high dynamic range characterization of the human plasma proteome.

Shen Y, Jacobs JM, Camp DG, Fang R, Moore RJ, Smith RD, Xiao W, Davis RW, Tompkins RG
Anal Chem. 2004;76(4):1134-44 - PMID: 14961748

The Caenorhabditis elegans MAPK phosphatase VHP-1 mediates a novel JNK-like signaling pathway in stress response.

Mizuno T, Hisamoto N, Terada T, Kondo T, Adachi M, Nishida E, Kim DH, Ausubel FM, Matsumoto K
EMBO J. 2004;23(11):2226-34 - PMID: 15116070 - PMCID: PMC419906

VPEgamma exhibits a caspase-like activity that contributes to defense against pathogens.

Rojo E, Martín R, Carter C, Zouhar J, Pan S, Plotnikova J, Jin H, Paneque M, Sánchez-Serrano JJ, Baker B, Ausubel FM, Raikhel NV
Curr Biol. 2004;14(21):1897-906 - PMID: 15530390

Cytotoxicity of hydrogen peroxide produced by Enterococcus faecium.

Moy TI, Mylonakis E, Calderwood SB, Ausubel FM
Infect Immun. 2004;72(8):4512-20 - PMID: 15271910 - PMCID: PMC470665

Construction of an Enterococcus faecalis Tn917-mediated-gene-disruption library offers insight into Tn917 insertion patterns.

Garsin DA, Urbach J, Huguet-Tapia JC, Peters JE, Ausubel FM
J Bacteriol. 2004;186(21):7280-9 - PMID: 15489440 - PMCID: PMC523214

Integration of Caenorhabditis elegans MAPK pathways mediating immunity and stress resistance by MEK-1 MAPK kinase and VHP-1 MAPK phosphatase.

Kim DH, Liberati NT, Mizuno T, Inoue H, Hisamoto N, Matsumoto K, Ausubel FM
Proc Natl Acad Sci U S A. 2004;101(30):10990-4 - PMID: 15256594 - PMCID: PMC503731

Contribution of gelatinase, serine protease, and fsr to the pathogenesis of Enterococcus faecalis endophthalmitis.

Engelbert M, Mylonakis E, Ausubel FM, Calderwood SB, Gilmore MS
Infect Immun. 2004;72(6):3628-33 - PMID: 15155673 - PMCID: PMC415677

Challenge of Drosophila melanogaster with Cryptococcus neoformans and role of the innate immune response.

Apidianakis Y, Rahme LG, Heitman J, Ausubel FM, Calderwood SB, Mylonakis E
Eukaryot Cell. 2004;3(2):413-9 - PMID: 15075271 - PMCID: PMC387633

Caenorhabditis elegans-based screen identifies Salmonella virulence factors required for conserved host-pathogen interactions.

Tenor JL, McCormick BA, Ausubel FM, Aballay A
Curr Biol. 2004;14(11):1018-24 - PMID: 15182677

Cryptococcus neoformans Kin1 protein kinase homologue, identified through a Caenorhabditis elegans screen, promotes virulence in mammals.

Mylonakis E, Idnurm A, Moreno R, El Khoury J, Rottman JB, Ausubel FM, Heitman J, Calderwood SB
Mol Microbiol. 2004;54(2):407-19 - PMID: 15469513

Evolutionary optimization of a nonbiological ATP binding protein for improved folding stability.

Chaput JC, Szostak JW
Chem Biol. 2004;11(6):865-74 - PMID: 15217619

Replicating vesicles as models of primitive cell growth and division.

Hanczyc MM, Szostak JW
Curr Opin Chem Biol. 2004;8(6):660-4 - PMID: 15556412

Membrane growth can generate a transmembrane pH gradient in fatty acid vesicles.

Chen IA, Szostak JW
Proc Natl Acad Sci U S A. 2004;101(21):7965-70 - PMID: 15148394 - PMCID: PMC419540

The emergence of competition between model protocells.

Chen IA, Roberts RW, Szostak JW
Science. 2004;305(5689):1474-6 - PMID: 15353806 - PMCID: PMC4484590

A kinetic study of the growth of fatty acid vesicles.

Chen IA, Szostak JW
Biophys J. 2004;87(2):988-98 - PMID: 15298905 - PMCID: PMC1304506

Informational complexity and functional activity of RNA structures.

Carothers JM, Oestreich SC, Davis JH, Szostak JW
J Am Chem Soc. 2004;126(16):5130-7 - PMID: 15099096 - PMCID: PMC5042360

A small aptamer with strong and specific recognition of the triphosphate of ATP.

Sazani PL, Larralde R, Szostak JW
J Am Chem Soc. 2004;126(27):8370-1 - PMID: 15237981 - PMCID: PMC4983724

High-throughput beta-galactosidase assay for bacterial cell-based reporter systems.

Thibodeau SA, Fang R, Joung JK
Biotechniques. 2004;36(3):410-5 - PMID: 15038156

Allosteric inhibition of zinc-finger binding in the major groove of DNA by minor-groove binding ligands.

Nguyen-Hackley DH, Ramm E, Taylor CM, Joung JK, Dervan PB, Pabo CO
Biochemistry. 2004;43(13):3880-90 - PMID: 15049695

The knockout mouse project.

Austin CP, Battey JF, Bradley A, Bucan M, Capecchi M, Collins FS, Dove WF, Duyk G, Dymecki S, Eppig JT, Grieder FB, Heintz N, Hicks G, Insel TR, Joyner A, Koller BH, Lloyd KC, Magnuson T, Moore MW, Nagy A, Pollock JD, Roses AD, Sands AT, Seed B, Skarnes WC, Snoddy J, Soriano P, Stewart DJ, Stewart F, Stillman B, Varmus H, Varticovski L, Verma IM, Vogt TF, von Melchner H, Witkowski J, Woychik RP, Wurst W, Yancopoulos GD, Young SG, Zambrowicz B
Nat Genet. 2004;36(9):921-4 - PMID: 15340423 - PMCID: PMC2716027

Differential transplantability of tumor-associated stromal cells.

Duda DG, Fukumura D, Munn LL, Booth MF, Brown EB, Huang P, Seed B, Jain RK
Cancer Res. 2004;64(17):5920-4 - PMID: 15342367

Cross-linking and lipid efflux properties of apoA-I mutants suggest direct association between apoA-I helices and ABCA1.

Chroni A, Liu T, Fitzgerald ML, Freeman MW, Zannis VI
Biochemistry. 2004;43(7):2126-39 - PMID: 14967052

Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways.

Björkbacka H, Kunjathoor VV, Moore KJ, Koehn S, Ordija CM, Lee MA, Means T, Halmen K, Luster AD, Golenbock DT, Freeman MW
Nat Med. 2004;10(4):416-21 - PMID: 15034566

ATP-binding cassette transporter A1 contains a novel C-terminal VFVNFA motif that is required for its cholesterol efflux and ApoA-I binding activities.

Fitzgerald ML, Okuhira K, Short GF, Manning JJ, Bell SA, Freeman MW
J Biol Chem. 2004;279(46):48477-85 - PMID: 15347662

The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades.

Björkbacka H, Fitzgerald KA, Huet F, Li X, Gregory JA, Lee MA, Ordija CM, Dowley NE, Golenbock DT, Freeman MW
Physiol Genomics. 2004;19(3):319-30 - PMID: 15367722

Abca7 null mice retain normal macrophage phosphatidylcholine and cholesterol efflux activity despite alterations in adipose mass and serum cholesterol levels.

Kim WS, Fitzgerald ML, Kang K, Okuhira K, Bell SA, Manning JJ, Koehn SL, Lu N, Moore KJ, Freeman MW
J Biol Chem. 2004;280(5):3989-95 - PMID: 15550377

Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis.

Ricci R, Sumara G, Sumara I, Rozenberg I, Kurrer M, Akhmedov A, Hersberger M, Eriksson U, Eberli FR, Becher B, Borén J, Chen M, Cybulsky MI, Moore KJ, Freeman MW, Wagner EF, Matter CM, Lüscher TF
Science. 2004;306(5701):1558-61 - PMID: 15567863

The complete genome and proteome of Mycoplasma mobile.

Jaffe JD, Stange-Thomann N, Smith C, DeCaprio D, Fisher S, Butler J, Calvo S, Elkins T, FitzGerald MG, Hafez N, Kodira CD, Major J, Wang S, Wilkinson J, Nicol R, Nusbaum C, Birren B, Berg HC, Church GM
Genome Res. 2004;14(8):1447-61 - PMID: 15289470 - PMCID: PMC509254

Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype.

Jaillon O, Aury JM, Brunet F, Petit JL, Stange-Thomann N, Mauceli E, Bouneau L, Fischer C, Ozouf-Costaz C, Bernot A, Nicaud S, Jaffe D, Fisher S, Lutfalla G, Dossat C, Segurens B, Dasilva C, Salanoubat M, Levy M, Boudet N, Castellano S, Anthouard V, Jubin C, Castelli V, Katinka M, Vacherie B, Biémont C, Skalli Z, Cattolico L, Poulain J, De Berardinis V, Cruaud C, Duprat S, Brottier P, Coutanceau JP, Gouzy J, Parra G, Lardier G, Chapple C, McKernan KJ, McEwan P, Bosak S, Kellis M, Volff JN, G ...
Nature. 2004;431(7011):946-57 - PMID: 15496914

A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans.

Kennedy S, Wang D, Ruvkun G
Nature. 2004;427(6975):645-9 - PMID: 14961122

Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network.

Tewari M, Hu PJ, Ahn JS, Ayivi-Guedehoussou N, Vidalain PO, Li S, Milstein S, Armstrong CM, Boxem M, Butler MD, Busiguina S, Rual JF, Ibarrola N, Chaklos ST, Bertin N, Vaglio P, Edgley ML, King KV, Albert PS, Vandenhaute J, Pandey A, Riddle DL, Ruvkun G, Vidal M
Mol Cell. 2004;13(4):469-82 - PMID: 14992718

The 20 years it took to recognize the importance of tiny RNAs.

Ruvkun G, Wightman B, Ha I
Cell. 2004;116(2 Suppl):S93-6, 2 p following S96 - PMID: 15055593

Intercellular signaling of reproductive development by the C. elegans DAF-9 cytochrome P450.

Mak HY, Ruvkun G
Development. 2004;131(8):1777-86 - PMID: 15084462

MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression.

Mansfield JH, Harfe BD, Nissen R, Obenauer J, Srineel J, Chaudhuri A, Farzan-Kashani R, Zuker M, Pasquinelli AE, Ruvkun G, Sharp PA, Tabin CJ, McManus MT
Nat Genet. 2004;36(10):1079-83 - PMID: 15361871

Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response.

Liberati NT, Fitzgerald KA, Kim DH, Feinbaum R, Golenbock DT, Ausubel FM
Proc Natl Acad Sci U S A. 2004;101(17):6593-8 - PMID: 15123841 - PMCID: PMC404090

Paradoxical roles of different nitric oxide synthase isoforms in colonic injury.

Beck PL, Xavier R, Wong J, Ezedi I, Mashimo H, Mizoguchi A, Mizoguchi E, Bhan AK, Podolsky DK
Am J Physiol Gastrointest Liver Physiol. 2004;286(1):G137-47 - PMID: 14665440

Chemotherapy- and radiotherapy-induced intestinal damage is regulated by intestinal trefoil factor.

Beck PL, Wong JF, Li Y, Swaminathan S, Xavier RJ, Devaney KL, Podolsky DK
Gastroenterology. 2004;126(3):796-808 - PMID: 14988834

The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death.

Rabizadeh S, Xavier RJ, Ishiguro K, Bernabeortiz J, Lopez-Ilasaca M, Khokhlatchev A, Mollahan P, Pfeifer GP, Avruch J, Seed B
J Biol Chem. 2004;279(28):29247-54 - PMID: 15075335

Discs large (Dlg1) complexes in lymphocyte activation.

Xavier R, Rabizadeh S, Ishiguro K, Andre N, Ortiz JB, Wachtel H, Morris DG, Lopez-Ilasaca M, Shaw AC, Swat W, Seed B
J Cell Biol. 2004;166(2):173-8 - PMID: 15263016 - PMCID: PMC2172307

Wave2 activates serum response element via its VCA region and functions downstream of Rac.

Ishiguro K, Cao Z, Ilasca ML, Ando T, Xavier R
Exp Cell Res. 2004;301(2):331-7 - PMID: 15530867

Expression of an active tobacco mitogen-activated protein kinase kinase kinase enhances freezing tolerance in transgenic maize.

Shou H, Bordallo P, Fan JB, Yeakley JM, Bibikova M, Sheen J, Wang K
Proc Natl Acad Sci U S A. 2004;101(9):3298-303 - PMID: 14960727 - PMCID: PMC365784

Central role of interleukin-6 in burn induced stimulation of hepatic amino acid transport.

Pawlik TM, Carter EA, Bode BP, Fischman AJ, Tompkins RG
Int J Mol Med. 2003;12(4):541-8 - PMID: 12964032

The Drosophila melanogaster toll pathway participates in resistance to infection by the gram-negative human pathogen Pseudomonas aeruginosa.

Lau GW, Goumnerov BC, Walendziewicz CL, Hewitson J, Xiao W, Mahajan-Miklos S, Tompkins RG, Perkins LA, Rahme LG
Infect Immun. 2003;71(7):4059-66 - PMID: 12819096 - PMCID: PMC162001

Efficacy of an extracorporeal flat-plate bioartificial liver in treating fulminant hepatic failure.

Shito M, Tilles AW, Tompkins RG, Yarmush ML, Toner M
J Surg Res. 2003;111(1):53-62 - PMID: 12842448

Bioengineering of liver assist devices.

Tilles AW, Berthiaume F, Yarmush ML, Tompkins RG, Toner M
J Hepatobiliary Pancreat Surg. 2003;9(6):686-96 - PMID: 12658402

Metabolic fate of extrahepatic arginine in liver after burn injury.

Chen CL, Fei Z, Carter EA, Lu XM, Hu RH, Young VR, Tompkins RG, Yu YM
Metabolism. 2003;52(10):1232-9 - PMID: 14564672

Five components of the ethylene-response pathway identified in a screen for weak ethylene-insensitive mutants in Arabidopsis.

Alonso JM, Stepanova AN, Solano R, Wisman E, Ferrari S, Ausubel FM, Ecker JR
Proc Natl Acad Sci U S A. 2003;100(5):2992-7 - PMID: 12606727 - PMCID: PMC151454

The art of serendipity: killing of Caenorhabditis elegans by human pathogens as a model of bacterial and fungal pathogenesis.

Mylonakis E, Ausubel FM, Tang RJ, Calderwood SB
Expert Rev Anti Infect Ther. 2003;1(1):167-73 - PMID: 15482109

Use of the Galleria mellonella caterpillar as a model host to study the role of the type III secretion system in Pseudomonas aeruginosa pathogenesis.

Miyata S, Casey M, Frank DW, Ausubel FM, Drenkard E
Infect Immun. 2003;71(5):2404-13 - PMID: 12704110 - PMCID: PMC153283

Caenorhabditis elegans as a model host for Staphylococcus aureus pathogenesis.

Sifri CD, Begun J, Ausubel FM, Calderwood SB
Infect Immun. 2003;71(4):2208-17 - PMID: 12654843 - PMCID: PMC152095

Tandemly duplicated Arabidopsis genes that encode polygalacturonase-inhibiting proteins are regulated coordinately by different signal transduction pathways in response to fungal infection.

Ferrari S, Vairo D, Ausubel FM, Cervone F, De Lorenzo G
Plant Cell. 2003;15(1):93-106 - PMID: 12509524 - PMCID: PMC143454

Hypersusceptibility of cystic fibrosis mice to chronic Pseudomonas aeruginosa oropharyngeal colonization and lung infection.

Coleman FT, Mueschenborn S, Meluleni G, Ray C, Carey VJ, Vargas SO, Cannon CL, Ausubel FM, Pier GB
Proc Natl Acad Sci U S A. 2003;100(4):1949-54 - PMID: 12578988 - PMCID: PMC149939

Functional information: Molecular messages.

Szostak JW
Nature. 2003;423(6941):689 - PMID: 12802312

Evolution of aptamers with a new specificity and new secondary structures from an ATP aptamer.

Huang Z, Szostak JW
RNA. 2003;9(12):1456-63 - PMID: 14624002 - PMCID: PMC1370500

DNA polymerase-mediated DNA synthesis on a TNA template.

Chaput JC, Ichida JK, Szostak JW
J Am Chem Soc. 2003;125(4):856-7 - PMID: 12537469

A novel, modification-dependent ATP-binding aptamer selected from an RNA library incorporating a cationic functionality.

Vaish NK, Larralde R, Fraley AW, Szostak JW, McLaughlin LW
Biochemistry. 2003;42(29):8842-51 - PMID: 12873145

Selective labeling and detection of specific RNAs in an RNA mixture.

Huang Z, Szostak JW
Anal Biochem. 2003;315(1):129-33 - PMID: 12672421

Experimental models of primitive cellular compartments: encapsulation, growth, and division.

Hanczyc MM, Fujikawa SM, Szostak JW
Science. 2003;302(5645):618-22 - PMID: 14576428 - PMCID: PMC4484575

TNA synthesis by DNA polymerases.

Chaput JC, Szostak JW
J Am Chem Soc. 2003;125(31):9274-5 - PMID: 12889939

Apoptotic cells and innate immune stimuli combine to regulate macrophage cytokine secretion.

Lucas M, Stuart LM, Savill J, Lacy-Hulbert A
J Immunol. 2003;171(5):2610-5 - PMID: 12928413

Highly specific zinc finger proteins obtained by directed domain shuffling and cell-based selection.

Hurt JA, Thibodeau SA, Hirsh AS, Pabo CO, Joung JK
Proc Natl Acad Sci U S A. 2003;100(21):12271-6 - PMID: 14527993 - PMCID: PMC218748

Efficient and stable retroviral transfection of ovine endothelial cells with green fluorescent protein for cardiovascular tissue engineering.

Afting M, Stock UA, Nasseri B, Pomerantseva I, Seed B, Vacanti JP
Tissue Eng. 2003;9(1):137-41 - PMID: 12625962

Site-specific gene targeting in mouse embryonic stem cells with intact bacterial artificial chromosomes.

Yang Y, Seed B
Nat Biotechnol. 2003;21(4):447-51 - PMID: 12627171

Epstein-Barr virus latent infection membrane protein 1 TRAF-binding site induces NIK/IKK alpha-dependent noncanonical NF-kappaB activation.

Luftig M, Yasui T, Soni V, Kang MS, Jacobson N, Cahir-McFarland E, Seed B, Kieff E
Proc Natl Acad Sci U S A. 2003;101(1):141-6 - PMID: 14691250 - PMCID: PMC314152

Selection of oligonucleotide probes for protein coding sequences.

Wang X, Seed B
Bioinformatics. 2003;19(7):796-802 - PMID: 12724288

Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation.

Brown E, McKee T, diTomaso E, Pluen A, Seed B, Boucher Y, Jain RK
Nat Med. 2003;9(6):796-800 - PMID: 12754503

A PCR primer bank for quantitative gene expression analysis.

Wang X, Seed B
Nucleic Acids Res. 2003;31(24):e154 - PMID: 14654707 - PMCID: PMC291882

The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.

Lichtenthaler SF, Dominguez DI, Westmeyer GG, Reiss K, Haass C, Saftig P, De Strooper B, Seed B
J Biol Chem. 2003;278(49):48713-9 - PMID: 14507929

eLiXiRs for restraining inflammation.

Freeman MW, Moore KJ
Nat Med. 2003;9(2):168-9 - PMID: 12563335

CD36 mediates the innate host response to beta-amyloid.

El Khoury JB, Moore KJ, Means TK, Leung J, Terada K, Toft M, Freeman MW, Luster AD
J Exp Med. 2003;197(12):1657-66 - PMID: 12796468 - PMCID: PMC2193948

Activation of signaling pathways by putative scavenger receptor class A (SR-A) ligands requires CD14 but not SR-A.

Kim WS, Ordija CM, Freeman MW
Biochem Biophys Res Commun. 2003;310(2):542-9 - PMID: 14521944

ABCA1 and amphipathic apolipoproteins form high-affinity molecular complexes required for cholesterol efflux.

Fitzgerald ML, Morris AL, Chroni A, Mendez AJ, Zannis VI, Freeman MW
J Lipid Res. 2003;45(2):287-94 - PMID: 14617740

Pathogen discovery from human tissue by sequence-based computational subtraction.

Xu Y, Stange-Thomann N, Weber G, Bo R, Dodge S, David RG, Foley K, Beheshti J, Harris NL, Birren B, Lander ES, Meyerson M
Genomics. 2003;81(3):329-35 - PMID: 12659816

The genome sequence of the filamentous fungus Neurospora crassa.

Galagan JE, Calvo SE, Borkovich KA, Selker EU, Read ND, Jaffe D, FitzHugh W, Ma LJ, Smirnov S, Purcell S, Rehman B, Elkins T, Engels R, Wang S, Nielsen CB, Butler J, Endrizzi M, Qui D, Ianakiev P, Bell-Pedersen D, Nelson MA, Werner-Washburne M, Selitrennikoff CP, Kinsey JA, Braun EL, Zelter A, Schulte U, Kothe GO, Jedd G, Mewes W, Staben C, Marcotte E, Greenberg D, Roy A, Foley K, Naylor J, Stange-Thomann N, Barrett R, Gnerre S, Kamal M, Kamvysselis M, Mauceli E, Bielke C, Rudd S, Frishman D ...
Nature. 2003;422(6934):859-68 - PMID: 12712197

Anteroposterior patterning in hemichordates and the origins of the chordate nervous system.

Lowe CJ, Wu M, Salic A, Evans L, Lander E, Stange-Thomann N, Gruber CE, Gerhart J, Kirschner M
Cell. 2003;113(7):853-65 - PMID: 12837244

Comparative genomic analysis reveals independent expansion of a lineage-specific gene family in vertebrates: the class II cytokine receptors and their ligands in mammals and fish.

Lutfalla G, Roest Crollius H, Stange-Thomann N, Jaillon O, Mogensen K, Monneron D
BMC Genomics. 2003;4(1):29 - PMID: 12869211 - PMCID: PMC179897

Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes.

Ashrafi K, Chang FY, Watts JL, Fraser AG, Kamath RS, Ahringer J, Ruvkun G
Nature. 2003;421(6920):268-72 - PMID: 12529643

A uniform system for microRNA annotation.

Ambros V, Bartel B, Bartel DP, Burge CB, Carrington JC, Chen X, Dreyfuss G, Eddy SR, Griffiths-Jones S, Marshall M, Matzke M, Ruvkun G, Tuschl T
RNA. 2003;9(3):277-9 - PMID: 12592000 - PMCID: PMC1370393

daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway.

Li W, Kennedy SG, Ruvkun G
Genes Dev. 2003;17(7):844-58 - PMID: 12654727 - PMCID: PMC196030

DAF-16 target genes that control C. elegans life-span and metabolism.

Lee SS, Kennedy S, Tolonen AC, Ruvkun G
Science. 2003;300(5619):644-7 - PMID: 12690206

Computational and experimental identification of C. elegans microRNAs.

Grad Y, Aach J, Hayes GD, Reinhart BJ, Church GM, Ruvkun G, Kim J
Mol Cell. 2003;11(5):1253-63 - PMID: 12769849

The Caenorhabditis elegans ems class homeobox gene ceh-2 is required for M3 pharynx motoneuron function.

Aspöck G, Ruvkun G, Bürglin TR
Development. 2003;130(15):3369-78 - PMID: 12810585

Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis.

Bashirullah A, Pasquinelli AE, Kiger AA, Perrimon N, Ruvkun G, Thummel CS
Dev Biol. 2003;259(1):1-8 - PMID: 12812783

Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens.

Garsin DA, Villanueva JM, Begun J, Kim DH, Sifri CD, Calderwood SB, Ruvkun G, Ausubel FM
Science. 2003;300(5627):1921 - PMID: 12817143

Expression of the 22 nucleotide let-7 heterochronic RNA throughout the Metazoa: a role in life history evolution?

Pasquinelli AE, McCoy A, Jiménez E, Saló E, Ruvkun G, Martindale MQ, Baguñà J
Evol Dev. 2003;5(4):372-8 - PMID: 12823453

Activity of the Caenorhabditis elegans UNC-86 POU transcription factor modulates olfactory sensitivity.

Sze JY, Ruvkun G
Proc Natl Acad Sci U S A. 2003;100(16):9560-5 - PMID: 12883006 - PMCID: PMC170957

Functional tests of enhancer conservation between distantly related species.

Ruvinsky I, Ruvkun G
Development. 2003;130(21):5133-42 - PMID: 12944426

Identification of many microRNAs that copurify with polyribosomes in mammalian neurons.

Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G
Proc Natl Acad Sci U S A. 2003;101(1):360-5 - PMID: 14691248 - PMCID: PMC314190

Unraveling the secrets of the cell.

Komaroff AL, Ruvkun G
Newsweek. 2003;142(23):96 - PMID: 14712576

Caenorhabditis elegans innate immune response triggered by Salmonella enterica requires intact LPS and is mediated by a MAPK signaling pathway.

Aballay A, Drenkard E, Hilbun LR, Ausubel FM
Curr Biol. 2003;13(1):47-52 - PMID: 12526744

Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens.

Garsin DA, Villanueva JM, Begun J, Kim DH, Sifri CD, Calderwood SB, Ruvkun G, Ausubel FM
Science. 2003;300(5627):1921 - PMID: 12817143

Arabidopsis local resistance to Botrytis cinerea involves salicylic acid and camalexin and requires EDS4 and PAD2, but not SID2, EDS5 or PAD4.

Ferrari S, Plotnikova JM, De Lorenzo G, Ausubel FM
Plant J. 2003;35(2):193-205 - PMID: 12848825

Transforming growth factor-beta mediates intestinal healing and susceptibility to injury in vitro and in vivo through epithelial cells.

Beck PL, Rosenberg IM, Xavier RJ, Koh T, Wong JF, Podolsky DK
Am J Pathol. 2003;162(2):597-608 - PMID: 12547717 - PMCID: PMC1851153

Essential role for Vav1 in activation, but not development, of gammadelta T cells.

Swat W, Xavier R, Mizoguchi A, Mizoguchi E, Fredericks J, Fujikawa K, Bhan AK, Alt FW
Int Immunol. 2003;15(2):215-21 - PMID: 12578851

Colonic epithelial functional phenotype varies with type and phase of experimental colitis.

Mizoguchi E, Xavier RJ, Reinecker HC, Uchino H, Bhan AK, Podolsky DK, Mizoguchi A
Gastroenterology. 2003;125(1):148-61 - PMID: 12851880

Homer-3 regulates activation of serum response element in T cells via its EVH1 domain.

Ishiguro K, Xavier R
Blood. 2003;103(6):2248-56 - PMID: 14645007

Sugar and hormone connections.

León P, Sheen J
Trends Plant Sci. 2003;8(3):110-6 - PMID: 12663220

Role of the Arabidopsis glucose sensor HXK1 in nutrient, light, and hormonal signaling.

Moore B, Zhou L, Rolland F, Hall Q, Cheng WH, Liu YX, Hwang I, Jones T, Sheen J
Science. 2003;300(5617):332-6 - PMID: 12690200

Differential regulation of EIN3 stability by glucose and ethylene signalling in plants.

Yanagisawa S, Yoo SD, Sheen J
Nature. 2003;425(6957):521-5 - PMID: 14523448

An improved strategy for constructing "designer" Cys2His2 zinc finger proteins.

Thibodeau SA, Joung JK
Discov Med. 2003;3(19):32-5 - PMID: 20705034

Use of Integra artificial skin is associated with decreased length of stay for severely injured adult burn survivors.

Ryan CM, Schoenfeld DA, Malloy M, Schulz JT, Sheridan RL, Tompkins RG
J Burn Care Rehabil. 2002;23(5):311-7 - PMID: 12352131

Effectiveness of bacteria-controlled nursing units in preventing cross-colonization with resistant bacteria in severely burned children.

Weber JM, Sheridan RL, Schulz JT, Tompkins RG, Ryan CM
Infect Control Hosp Epidemiol. 2002;23(9):549-51 - PMID: 12269456

Plasma L-5-oxoproline kinetics and whole blood glutathione synthesis rates in severely burned adult humans.

Yu YM, Ryan CM, Fei ZW, Lu XM, Castillo L, Schultz JT, Tompkins RG, Young VR
Am J Physiol Endocrinol Metab. 2002;282(2):E247-58 - PMID: 11788355

Inducible nitric oxide synthase plays a role in LPS-induced hyperglycemia and insulin resistance.

Sugita H, Kaneki M, Tokunaga E, Sugita M, Koike C, Yasuhara S, Tompkins RG, Martyn JA
Am J Physiol Endocrinol Metab. 2002;282(2):E386-94 - PMID: 11788371

Mapping of local renal blood flow with PET and H(2)(15)O.

Alpert NM, Rabito CA, Correia DJ, Babich JW, Littman BH, Tompkins RG, Rubin NT, Rubin RH, Fischman AJ
J Nucl Med. 2002;43(4):470-5 - PMID: 11937589

Regional measurement of canine skeletal muscle blood flow by positron emission tomography with H2(15)O.

Fischman AJ, Hsu H, Carter EA, Yu YM, Tompkins RG, Guerrero JL, Young VR, Alpert NM
J Appl Physiol. 2002;92(4):1709-16 - PMID: 11896041

Long-term consequences of toxic epidermal necrolysis in children.

Sheridan RL, Schulz JT, Ryan CM, Schnitzer JJ, Lawlor D, Driscoll DN, Donelan MB, Tompkins RG
Pediatrics. 2002;109(1):74-8 - PMID: 11773544

In vivo rabbit hindquarter model for assessment of regional burn hypermetabolism.

Xu J, Fei Z, Yu YM, Xu W, Rhodes A, Tompkins RG, Schulz JT
J Appl Physiol. 2002;94(1):135-40 - PMID: 12391055

Identification of virulence genes in a pathogenic strain of Pseudomonas aeruginosa by representational difference analysis.

Choi JY, Sifri CD, Goumnerov BC, Rahme LG, Ausubel FM, Calderwood SB
J Bacteriol. 2002;184(4):952-61 - PMID: 11807055 - PMCID: PMC134824

Caenorhabditis elegans as a host for the study of host-pathogen interactions.

Aballay A, Ausubel FM
Curr Opin Microbiol. 2002;5(1):97-101 - PMID: 11834377

Strains of Escherichia coli O157:H7 differ primarily by insertions or deletions, not single-nucleotide polymorphisms.

Kudva IT, Evans PS, Perna NT, Barrett TJ, Ausubel FM, Blattner FR, Calderwood SB
J Bacteriol. 2002;184(7):1873-9 - PMID: 11889093 - PMCID: PMC134921

Virulence effect of Enterococcus faecalis protease genes and the quorum-sensing locus fsr in Caenorhabditis elegans and mice.

Sifri CD, Mylonakis E, Singh KV, Qin X, Garsin DA, Murray BE, Ausubel FM, Calderwood SB
Infect Immun. 2002;70(10):5647-50 - PMID: 12228293 - PMCID: PMC128331

Killing of Caenorhabditis elegans by Cryptococcus neoformans as a model of yeast pathogenesis.

Mylonakis E, Ausubel FM, Perfect JR, Heitman J, Calderwood SB
Proc Natl Acad Sci U S A. 2002;99(24):15675-80 - PMID: 12438649 - PMCID: PMC137775

Polymorphic amplified typing sequences provide a novel approach to Escherichia coli O157:H7 strain typing.

Kudva IT, Evans PS, Perna NT, Barrett TJ, DeCastro GJ, Ausubel FM, Blattner FR, Calderwood SB
J Clin Microbiol. 2002;40(4):1152-9 - PMID: 11923324 - PMCID: PMC140341

Signals involved in Arabidopsis resistance to Trichoplusia ni caterpillars induced by virulent and avirulent strains of the phytopathogen Pseudomonas syringae.

Cui J, Jander G, Racki LR, Kim PD, Pierce NE, Ausubel FM
Plant Physiol. 2002;129(2):551-64 - PMID: 12068100 - PMCID: PMC161673

The Enterococcus faecalis fsrB gene, a key component of the fsr quorum-sensing system, is associated with virulence in the rabbit endophthalmitis model.

Mylonakis E, Engelbert M, Qin X, Sifri CD, Murray BE, Ausubel FM, Gilmore MS, Calderwood SB
Infect Immun. 2002;70(8):4678-81 - PMID: 12117982 - PMCID: PMC128160

Molecular biology: RNA gets a grip on translation.

Szostak JW
Nature. 2002;419(6910):890-1 - PMID: 12410294

Identification of epitope-like consensus motifs using mRNA display.

Baggio R, Burgstaller P, Hale SP, Putney AR, Lane M, Lipovsek D, Wright MC, Roberts RW, Liu R, Szostak JW, Wagner RW
J Mol Recognit. 2002;15(3):126-34 - PMID: 12203838

Isolation of high-affinity GTP aptamers from partially structured RNA libraries.

Davis JH, Szostak JW
Proc Natl Acad Sci U S A. 2002;99(18):11616-21 - PMID: 12185247 - PMCID: PMC129318

Inhibitory effects of apoptotic cell ingestion upon endotoxin-driven myeloid dendritic cell maturation.

Stuart LM, Lucas M, Simpson C, Lamb J, Savill J, Lacy-Hulbert A
J Immunol. 2002;168(4):1627-35 - PMID: 11823490

Identifying and modifying protein-DNA and protein-protein interactions using a bacterial two-hybrid selection system.

Joung JK
J Cell Biochem Suppl. 2002;Suppl 37:53-7 - PMID: 11842428

Ductal lavage and the clinical management of women at high risk for breast carcinoma: a commentary.

O'Shaughnessy JA, Ljung BM, Dooley WC, Chang J, Kuerer HM, Hung DT, Grant MD, Khan SA, Phillips RF, Duvall K, Euhus DM, King BL, Anderson BO, Troyan SL, Kim J, Veronesi U, Cazzaniga M
Cancer. 2002;94(2):292-8 - PMID: 11900214

The Treatment of Dyslipidemia: LDL Reduction and Beyond

MW Freeman
In Endocrinology Rounds. 2002;1, Issue 8:ePub

C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway.

Rosen ED, Hsu CH, Wang X, Sakai S, Freeman MW, Gonzalez FJ, Spiegelman BM
Genes Dev. 2002;16(1):22-6 - PMID: 11782441 - PMCID: PMC155311

Nuclear hormone receptors and cholesterol trafficking: the orphans find a new home.

Fitzgerald ML, Moore KJ, Freeman MW
J Mol Med (Berl). 2002;80(5):271-81 - PMID: 12021839

Naturally occurring mutations in the largest extracellular loops of ABCA1 can disrupt its direct interaction with apolipoprotein A-I.

Fitzgerald ML, Morris AL, Rhee JS, Andersson LP, Mendez AJ, Freeman MW
J Biol Chem. 2002;277(36):33178-87 - PMID: 12084722

A CD36-initiated signaling cascade mediates inflammatory effects of beta-amyloid.

Moore KJ, El Khoury J, Medeiros LA, Terada K, Geula C, Luster AD, Freeman MW
J Biol Chem. 2002;277(49):47373-9 - PMID: 12239221

Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways.

Henneke P, Takeuchi O, Malley R, Lien E, Ingalls RR, Freeman MW, Mayadas T, Nizet V, Akira S, Kasper DL, Golenbock DT
J Immunol. 2002;169(7):3970-7 - PMID: 12244198

Neutrophil influx in response to a peritoneal infection with Salmonella is delayed in lipopolysaccharide-binding protein or CD14-deficient mice.

Yang KK, Dorner BG, Merkel U, Ryffel B, Schütt C, Golenbock D, Freeman MW, Jack RS
J Immunol. 2002;169(8):4475-80 - PMID: 12370383

Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages.

Kunjathoor VV, Febbraio M, Podrez EA, Moore KJ, Andersson L, Koehn S, Rhee JS, Silverstein R, Hoff HF, Freeman MW
J Biol Chem. 2002;277(51):49982-8 - PMID: 12376530

The genome of M. acetivorans reveals extensive metabolic and physiological diversity.

Galagan JE, Nusbaum C, Roy A, Endrizzi MG, Macdonald P, FitzHugh W, Calvo S, Engels R, Smirnov S, Atnoor D, Brown A, Allen N, Naylor J, Stange-Thomann N, DeArellano K, Johnson R, Linton L, McEwan P, McKernan K, Talamas J, Tirrell A, Ye W, Zimmer A, Barber RD, Cann I, Graham DE, Grahame DA, Guss AM, Hedderich R, Ingram-Smith C, Kuettner HC, Krzycki JA, Leigh JA, Li W, Liu J, Mukhopadhyay B, Reeve JN, Smith K, Springer TA, Umayam LA, White O, White RH, Conway de Macario E, Ferry JG, Jarrell KF ...
Genome Res. 2002;12(4):532-42 - PMID: 11932238 - PMCID: PMC187521

Initial sequencing and comparative analysis of the mouse genome.

Mouse Genome Sequencing Consortium, Waterston RH, Lindblad-Toh K, Birney E, Rogers J, Abril JF, Agarwal P, Agarwala R, Ainscough R, Alexandersson M, An P, Antonarakis SE, Attwood J, Baertsch R, Bailey J, Barlow K, Beck S, Berry E, Birren B, Bloom T, Bork P, Botcherby M, Bray N, Brent MR, Brown DG, Brown SD, Bult C, Burton J, Butler J, Campbell RD, Carninci P, Cawley S, Chiaromonte F, Chinwalla AT, Church DM, Clamp M, Clee C, Collins FS, Cook LL, Copley RR, Coulson A, Couronne O, Cuff J, Curw ...
Nature. 2002;420(6915):520-62 - PMID: 12466850

Longevity: don't hold your breath.

Lee SS, Ruvkun G
Nature. 2002;418(6895):287-8 - PMID: 12124610

The C. elegans POU-domain transcription factor UNC-86 regulates the tph-1 tryptophan hydroxylase gene and neurite outgrowth in specific serotonergic neurons.

Sze JY, Zhang S, Li J, Ruvkun G
Development. 2002;129(16):3901-11 - PMID: 12135927

Control of developmental timing by micrornas and their targets.

Pasquinelli AE, Ruvkun G
Annu Rev Cell Dev Biol. 2002;18:495-513 - PMID: 12142272

Insulin receptor substrate and p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway.

Wolkow CA, Muñoz MJ, Riddle DL, Ruvkun G
J Biol Chem. 2002;277(51):49591-7 - PMID: 12393910

A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity.

Lee SS, Lee RY, Fraser AG, Kamath RS, Ahringer J, Ruvkun G
Nat Genet. 2002;33(1):40-8 - PMID: 12447374

Pseudomonas biofilm formation and antibiotic resistance are linked to phenotypic variation.

Drenkard E, Ausubel FM
Nature. 2002;416(6882):740-3 - PMID: 11961556

A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity.

Kim DH, Feinbaum R, Alloing G, Emerson FE, Garsin DA, Inoue H, Tanaka-Hino M, Hisamoto N, Matsumoto K, Tan MW, Ausubel FM
Science. 2002;297(5581):623-6 - PMID: 12142542

Role of tumor necrosis factor receptor 2 (TNFR2) in colonic epithelial hyperplasia and chronic intestinal inflammation in mice.

Mizoguchi E, Mizoguchi A, Takedatsu H, Cario E, de Jong YP, Ooi CJ, Xavier RJ, Terhorst C, Podolsky DK, Bhan AK
Gastroenterology. 2002;122(1):134-44 - PMID: 11781288

Identification of a novel Ras-regulated proapoptotic pathway.

Khokhlatchev A, Rabizadeh S, Xavier R, Nedwidek M, Chen T, Zhang XF, Seed B, Avruch J
Curr Biol. 2002;12(4):253-65 - PMID: 11864565

Decreased bone density in splenectomized Gaucher patients receiving enzyme replacement therapy.

Schiffmann R, Mankin H, Dambrosia JM, Xavier RJ, Kreps C, Hill SC, Barton NW, Rosenthal DI
Blood Cells Mol Dis. 2002;28(2):288-96 - PMID: 12064924

MAP kinase signalling cascade in Arabidopsis innate immunity.

Asai T, Tena G, Plotnikova J, Willmann MR, Chiu WL, Gomez-Gomez L, Boller T, Ausubel FM, Sheen J
Nature. 2002;415(6875):977-83 - PMID: 11875555

Phosphorelay and transcription control in cytokinin signal transduction.

Sheen J
Science. 2002;296(5573):1650-2 - PMID: 12040183

Sugar sensing and signaling in plants.

Rolland F, Moore B, Sheen J
Plant Cell. 2002;14 Suppl:S185-205 - PMID: 12045277 - PMCID: PMC151255

Calcium signaling through protein kinases. The Arabidopsis calcium-dependent protein kinase gene family.

Cheng SH, Willmann MR, Chen HC, Sheen J
Plant Physiol. 2002;129(2):469-85 - PMID: 12068094 - PMCID: PMC1540234

Two-component signal transduction pathways in Arabidopsis.

Hwang I, Chen HC, Sheen J
Plant Physiol. 2002;129(2):500-15 - PMID: 12068096 - PMCID: PMC161668

A unique short-chain dehydrogenase/reductase in Arabidopsis glucose signaling and abscisic acid biosynthesis and functions.

Cheng WH, Endo A, Zhou L, Penney J, Chen HC, Arroyo A, Leon P, Nambara E, Asami T, Seo M, Koshiba T, Sheen J
Plant Cell. 2002;14(11):2723-43 - PMID: 12417697 - PMCID: PMC152723

L-histidine decarboxylase decreases its own transcription through downregulation of ERK activity.

Colucci R, Fleming JV, Xavier R, Wang TC
Am J Physiol Gastrointest Liver Physiol. 2001;281(4):G1081-91 - PMID: 11557529

Hepatitis C virus replication is directly inhibited by IFN-alpha in a full-length binary expression system.

Chung RT, He W, Saquib A, Contreras AM, Xavier RJ, Chawla A, Wang TC, Schmidt EV
Proc Natl Acad Sci U S A. 2001;98(17):9847-52 - PMID: 11493707 - PMCID: PMC55541

Gaucher disease. New approaches to an ancient disease.

Mankin HJ, Rosenthal DI, Xavier R
J Bone Joint Surg Am. 2001;83-A(5):748-62 - PMID: 11379747

TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome.

Merscher S, Funke B, Epstein JA, Heyer J, Puech A, Lu MM, Xavier RJ, Demay MB, Russell RG, Factor S, Tokooya K, Jore BS, Lopez M, Pandita RK, Lia M, Carrion D, Xu H, Schorle H, Kobler JB, Scambler P, Wynshaw-Boris A, Skoultchi AI, Morrow BE, Kucherlapati R
Cell. 2001;104(4):619-29 - PMID: 11239417

The American Burn Association in the New Millennium.

Tompkins RG
J Burn Care Rehabil. 2001;22(6):369-374 - PMID: 11773770

Initial experience with a composite autologous skin substitute.

Sheridan RL, Morgan JR, Cusick JL, Petras LM, Lydon MM, Tompkins RG
Burns. 2001;27(5):421-4 - PMID: 11451592

A fulminant hepatic failure model in the rat: involvement of interleukin-1beta and tumor necrosis factor-alpha.

Shito M, Balis UJ, Tompkins RG, Yarmush ML, Toner M
Dig Dis Sci. 2001;46(8):1700-8 - PMID: 11508670

Arginine and ornithine kinetics in severely burned patients: increased rate of arginine disposal.

Yu YM, Ryan CM, Castillo L, Lu XM, Beaumier L, Tompkins RG, Young VR
Am J Physiol Endocrinol Metab. 2001;280(3):E509-17 - PMID: 11171607

In vitro and in vivo evaluation of albumin synthesis rate of porcine hepatocytes in a flat-plate bioreactor.

Shito M, Kim NH, Baskaran H, Tilles AW, Tompkins RG, Yarmush ML, Toner M
Artif Organs. 2001;25(7):571-8 - PMID: 11493279

Intrahepatic amino acid and glucose metabolism in a D-galactosamine-induced rat liver failure model.

Arai K, Lee K, Berthiaume F, Tompkins RG, Yarmush ML
Hepatology. 2001;34(2):360-71 - PMID: 11481621

Young age is not a predictor of mortality in burns.

Sheridan RL, Weber JM, Schnitzer JJ, Schulz JT, Ryan CM, Tompkins RG
Pediatr Crit Care Med. 2001;2(3):223-224 - PMID: 12793945

Antibiotic prophylaxis for group A streptococcal burn wound infection is not necessary.

Sheridan RL, Weber JM, Pasternack MS, Tompkins RG
J Trauma. 2001;51(2):352-5 - PMID: 11493799

Long-term maintenance of cytochrome P450 activities by rat hepatocyte/3T3 cell co-cultures in heparinized human plasma.

Washizu J, Berthiaume F, Mokuno Y, Tompkins RG, Toner M, Yarmush ML
Tissue Eng. 2001;7(6):691-703 - PMID: 11749727

Differential roles of the Pseudomonas aeruginosa PA14 rpoN gene in pathogenicity in plants, nematodes, insects, and mice.

Hendrickson EL, Plotnikova J, Mahajan-Miklos S, Rahme LG, Ausubel FM
J Bacteriol. 2001;183(24):7126-34 - PMID: 11717271 - PMCID: PMC95561

The roles of mucD and alginate in the virulence of Pseudomonas aeruginosa in plants, nematodes and mice.

Yorgey P, Rahme LG, Tan MW, Ausubel FM
Mol Microbiol. 2001;41(5):1063-76 - PMID: 11555287

The TASTY locus on chromosome 1 of Arabidopsis affects feeding of the insect herbivore Trichoplusia ni.

Jander G, Cui J, Nhan B, Pierce NE, Ausubel FM
Plant Physiol. 2001;126(2):890-8 - PMID: 11402216 - PMCID: PMC111178

One-step purification of recombinant proteins using a nanomolar-affinity streptavidin-binding peptide, the SBP-Tag.

Keefe AD, Wilson DS, Seelig B, Szostak JW
Protein Expr Purif. 2001;23(3):440-6 - PMID: 11722181

Functional proteins from a random-sequence library.

Keefe AD, Szostak JW
Nature. 2001;410(6829):715-8 - PMID: 11287961 - PMCID: PMC4476321

In vitro evolution suggests multiple origins for the hammerhead ribozyme.

Salehi-Ashtiani K, Szostak JW
Nature. 2001;414(6859):82-4 - PMID: 11689947

Synthesizing life.

Szostak JW, Bartel DP, Luisi PL
Nature. 2001;409(6818):387-90 - PMID: 11201752

The use of mRNA display to select high-affinity protein-binding peptides.

Wilson DS, Keefe AD, Szostak JW
Proc Natl Acad Sci U S A. 2001;98(7):3750-5 - PMID: 11274392 - PMCID: PMC31124

Detection of breast cancer cells in ductal lavage fluid by methylation-specific PCR.

Evron E, Dooley WC, Umbricht CB, Rosenthal D, Sacchi N, Gabrielson E, Soito AB, Hung DT, Ljung B, Davidson NE, Sukumar S
Lancet. 2001;357(9265):1335-6 - PMID: 11343741

Ductal lavage for detection of cellular atypia in women at high risk for breast cancer.

Dooley WC, Ljung BM, Veronesi U, Cazzaniga M, Elledge RM, O'Shaughnessy JA, Kuerer HM, Hung DT, Khan SA, Phillips RF, Ganz PA, Euhus DM, Esserman LJ, Haffty BG, King BL, Kelley MC, Anderson MM, Schmit PJ, Clark RR, Kass FC, Anderson BO, Troyan SL, Arias RD, Quiring JN, Love SM, Page DL, King EB
J Natl Cancer Inst. 2001;93(21):1624-32 - PMID: 11698566

Lipid rafts and pseudotyping.

Pickl WF, Pimentel-Muiños FX, Seed B
J Virol. 2001;75(15):7175-83 - PMID: 11435598 - PMCID: PMC114446

Targeted disruption of the murine Fanconi anemia gene, Fancg/Xrcc9.

Yang Y, Kuang Y, Montes De Oca R, Hays T, Moreau L, Lu N, Seed B, D'Andrea AD
Blood. 2001;98(12):3435-40 - PMID: 11719385

Endoplasmic reticulum chaperone gp96 is required for innate immunity but not cell viability.

Randow F, Seed B
Nat Cell Biol. 2001;3(10):891-6 - PMID: 11584270

Identification of two sequences in the cytoplasmic tail of the human immunodeficiency virus type 1 envelope glycoprotein that inhibit cell surface expression.

Bültmann A, Muranyi W, Seed B, Haas J
J Virol. 2001;75(11):5263-76 - PMID: 11333908 - PMCID: PMC114932

Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo.

Fukumura D, Xu L, Chen Y, Gohongi T, Seed B, Jain RK
Cancer Res. 2001;61(16):6020-4 - PMID: 11507045

The role of PPAR-gamma in macrophage differentiation and cholesterol uptake.

Moore KJ, Rosen ED, Fitzgerald ML, Randow F, Andersson LP, Altshuler D, Milstone DS, Mortensen RM, Spiegelman BM, Freeman MW
Nat Med. 2001;7(1):41-7 - PMID: 11135614

Manipulating intestinal cholesterol absorption and hepatic cholesterol and bile acid metabolism by activation of deorphanized nuclear receptors.

Rigotti A, Freeman MW
Gastroenterology. 2001;120(4):1054-5 - PMID: 11231965

ATP-binding cassette transporter A1 contains an NH2-terminal signal anchor sequence that translocates the protein's first hydrophilic domain to the exoplasmic space.

Fitzgerald ML, Mendez AJ, Moore KJ, Andersson LP, Panjeton HA, Freeman MW
J Biol Chem. 2001;276(18):15137-45 - PMID: 11328826

Evidence that dendritic cells infiltrate atherosclerotic lesions in apolipoprotein E-deficient mice.

Bobryshev YV, Taksir T, Lord RS, Freeman MW
Histol Histopathol. 2001;16(3):801-8 - PMID: 11510970

Peroxisome proliferator-activated receptors in macrophage biology: friend or foe?

Moore KJ, Fitzgerald ML, Freeman MW
Curr Opin Lipidol. 2001;12(5):519-27 - PMID: 11561171

LBP, CD14, TLR4 and the murine innate immune response to a peritoneal Salmonella infection.

Bernheiden M, Heinrich JM, Minigo G, Schütt C, Stelter F, Freeman M, Golenbock D, Jack RS
J Endotoxin Res. 2001;7(6):447-50 - PMID: 11753215

Initial sequencing and analysis of the human genome.

Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, Devon K, Dewar K, Doyle M, FitzHugh W, Funke R, Gage D, Harris K, Heaford A, Howland J, Kann L, Lehoczky J, LeVine R, McEwan P, McKernan K, Meldrim J, Mesirov JP, Miranda C, Morris W, Naylor J, Raymond C, Rosetti M, Santos R, Sheridan A, Sougnez C, Stange-Thomann N, Stojanovic N, Subramanian A, Wyman D, Rogers J, Sulston J, Ainscough R, Beck S, Bentley D, Burton J, Clee C, Carter N, Coulson A, Deadman R, Deloukas P, Dunham A, Dun ...
Nature. 2001;409(6822):860-921 - PMID: 11237011

A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms.

Sachidanandam R, Weissman D, Schmidt SC, Kakol JM, Stein LD, Marth G, Sherry S, Mullikin JC, Mortimore BJ, Willey DL, Hunt SE, Cole CG, Coggill PC, Rice CM, Ning Z, Rogers J, Bentley DR, Kwok PY, Mardis ER, Yeh RT, Schultz B, Cook L, Davenport R, Dante M, Fulton L, Hillier L, Waterston RH, McPherson JD, Gilman B, Schaffner S, Van Etten WJ, Reich D, Higgins J, Daly MJ, Blumenstiel B, Baldwin J, Stange-Thomann N, Zody MC, Linton L, Lander ES, Altshuler D,
Nature. 2001;409(6822):928-33 - PMID: 11237013

Isoform-specific mutations in the Caenorhabditis elegans heterochronic gene lin-14 affect stage-specific patterning.

Reinhart BJ, Ruvkun G
Genetics. 2001;157(1):199-209 - PMID: 11139502 - PMCID: PMC1461488

Regulation of ectodermal and excretory function by the C. elegans POU homeobox gene ceh-6.

Bürglin TR, Ruvkun G
Development. 2001;128(5):779-90 - PMID: 11171402

Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family.

Pierce SB, Costa M, Wisotzkey R, Devadhar S, Homburger SA, Buchman AR, Ferguson KC, Heller J, Platt DM, Pasquinelli AA, Liu LX, Doberstein SK, Ruvkun G
Genes Dev. 2001;15(6):672-86 - PMID: 11274053 - PMCID: PMC312654

Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing.

Grishok A, Pasquinelli AE, Conte D, Li N, Parrish S, Ha I, Baillie DL, Fire A, Ruvkun G, Mello CC
Cell. 2001;106(1):23-34 - PMID: 11461699

Molecular biology. Glimpses of a tiny RNA world.

Ruvkun G
Science. 2001;294(5543):797-9 - PMID: 11679654

The genetics of aging.

Finch CE, Ruvkun G
Annu Rev Genomics Hum Genet. 2001;2:435-62 - PMID: 11701657

Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway.

Lee RY, Hench J, Ruvkun G
Curr Biol. 2001;11(24):1950-7 - PMID: 11747821

Programmed cell death mediated by ced-3 and ced-4 protects Caenorhabditis elegans from Salmonella typhimurium-mediated killing.

Aballay A, Ausubel FM
Proc Natl Acad Sci U S A. 2001;98(5):2735-9 - PMID: 11226309 - PMCID: PMC30208

A simple model host for identifying Gram-positive virulence factors.

Garsin DA, Sifri CD, Mylonakis E, Qin X, Singh KV, Murray BE, Calderwood SB, Ausubel FM
Proc Natl Acad Sci U S A. 2001;98(19):10892-7 - PMID: 11535834 - PMCID: PMC58570

Isochorismate synthase is required to synthesize salicylic acid for plant defence.

Wildermuth MC, Dewdney J, Wu G, Ausubel FM
Nature. 2001;414(6863):562-5 - PMID: 11734859

Mesophyll-specific, light and metabolic regulation of the C4 PPCZm1 promoter in transgenic maize.

Kausch AP, Owen TP, Zachwieja SJ, Flynn AR, Sheen J
Plant Mol Biol. 2001;45(1):1-15 - PMID: 11247600

Isotopic assays for reporter gene activity.

Kingston RE, Sheen J, Moore D
Curr Protoc Pharmacol. 2001;Chapter 6:Unit 6.4 - PMID: 21965075

Molecular identification of phenylalanine ammonia-lyase as a substrate of a specific constitutively active Arabidopsis CDPK expressed in maize protoplasts.

Cheng SH, Sheen J, Gerrish C, Bolwell GP
FEBS Lett. 2001;503(2-3):185-8 - PMID: 11513879

Two-component circuitry in Arabidopsis cytokinin signal transduction.

Hwang I, Sheen J
Nature. 2001;413(6854):383-9 - PMID: 11574878

Dissection of abscisic acid signal transduction pathways in barley aleurone layers.

Shen Q, Gomez-Cadenas A, Zhang P, Walker-Simmons MK, Sheen J, Ho TH
Plant Mol Biol. 2001;47(3):437-48 - PMID: 11587514

Plant mitogen-activated protein kinase signaling cascades.

Tena G, Asai T, Chiu WL, Sheen J
Curr Opin Plant Biol. 2001;4(5):392-400 - PMID: 11597496

Signal transduction in maize and Arabidopsis mesophyll protoplasts.

Sheen J
Plant Physiol. 2001;127(4):1466-75 - PMID: 11743090 - PMCID: PMC1540179

Introduction of plasmid DNA into cells.

Seidman CE, Struhl K, Sheen J, Jessen T
Curr Protoc Mol Biol. 2001;Chapter 1:Unit1.8 - PMID: 18265047

Isotopic assays for reporter gene activity.

Kingston RE, Sheen J, Moore D
Curr Protoc Mol Biol. 2001;Chapter 9:Unit9.7A - PMID: 18265285

Silanizing glassware.

Seed B
Curr Protoc Cell Biol. 2001;Appendix 3:Appendix 3E - PMID: 18228287

Silanizing glassware.

Seed B
Curr Protoc Mol Biol. 2001;Appendix 3:Appendix 3B - PMID: 18265032

Silanizing glassware.

Seed B
Curr Protoc Protein Sci. 2001;Appendix 3:Appendix 3E - PMID: 18429072

Silanizing glassware.

Seed B
Curr Protoc Immunol. 2001;Appendix 3:Appendix 3K - PMID: 18432662

Microbiology. How to get along--friendly microbes in a hostile world.

Xavier RJ, Podolsky DK
Science. 2000;289(5484):1483-4 - PMID: 10991734

Fractalkine is an epithelial and endothelial cell-derived chemoattractant for intraepithelial lymphocytes in the small intestinal mucosa.

Muehlhoefer A, Saubermann LJ, Gu X, Luedtke-Heckenkamp K, Xavier R, Blumberg RS, Podolsky DK, MacDermott RP, Reinecker HC
J Immunol. 2000;164(6):3368-76 - PMID: 10706732

Cutaneous herpetic infections complicating burns.

Sheridan RL, Schulz JT, Weber JM, Ryan CM, Pasternack MS, Tompkins RG
Burns. 2000;26(7):621-4 - PMID: 10925184

Management of severe toxic epidermal necrolysis in children.

Sheridan RL, Weber JM, Schulz JT, Ryan CM, Low HM, Tompkins RG
J Burn Care Rehabil. 2000;20(6):497-500 - PMID: 10613688

Current expectations for survival in pediatric burns.

Sheridan RL, Remensnyder JP, Schnitzer JJ, Schulz JT, Ryan CM, Tompkins RG
Arch Pediatr Adolesc Med. 2000;154(3):245-9 - PMID: 10710021

Amino acid supplementation improves cell-specific functions of the rat hepatocytes exposed to human plasma.

Washizu J, Chan C, Berthiaume F, Tompkins RG, Toner M, Yarmush ML
Tissue Eng. 2000;6(5):497-504 - PMID: 11074936

Optimization of rat hepatocyte culture in citrated human plasma.

Washizu J, Berthiaume F, Chan C, Tompkins RG, Toner M, Yarmush ML
J Surg Res. 2000;93(2):237-46 - PMID: 11027466

Blood glutathione synthesis rates in healthy adults receiving a sulfur amino acid-free diet.

Lyons J, Rauh-Pfeiffer A, Yu YM, Lu XM, Zurakowski D, Tompkins RG, Ajami AM, Young VR, Castillo L
Proc Natl Acad Sci U S A. 2000;97(10):5071-6 - PMID: 10792033 - PMCID: PMC25783

Artificial skin.

Schulz JT, Tompkins RG, Burke JF
Annu Rev Med. 2000;51:231-44 - PMID: 10774462

A 10-year experience with toxic epidermal necrolysis.

Schulz JT, Sheridan RL, Ryan CM, MacKool B, Tompkins RG
J Burn Care Rehabil. 2000;21(3):199-204 - PMID: 10850900

Long-term outcome of children surviving massive burns.

Sheridan RL, Hinson MI, Liang MH, Nackel AF, Schoenfeld DA, Ryan CM, Mulligan JL, Tompkins RG
JAMA. 2000;283(1):69-73 - PMID: 10632282

Positive correlation between virulence of Pseudomonas aeruginosa mutants in mice and insects.

Jander G, Rahme LG, Ausubel FM
J Bacteriol. 2000;182(13):3843-5 - PMID: 10851003 - PMCID: PMC94559

Elucidating the molecular mechanisms of bacterial virulence using non-mammalian hosts.

Mahajan-Miklos S, Rahme LG, Ausubel FM
Mol Microbiol. 2000;37(5):981-8 - PMID: 10972817

Caenorhabditis elegans: a model genetic host to study Pseudomonas aeruginosa pathogenesis.

Tan MW, Ausubel FM
Curr Opin Microbiol. 2000;3(1):29-34 - PMID: 10679415

Roles of salicylic acid, jasmonic acid, and ethylene in cpr-induced resistance in arabidopsis.

Clarke JD, Volko SM, Ledford H, Ausubel FM, Dong X
Plant Cell. 2000;12(11):2175-90 - PMID: 11090217 - PMCID: PMC150166

Three unique mutants of Arabidopsis identify eds loci required for limiting growth of a biotrophic fungal pathogen.

Dewdney J, Reuber TL, Wildermuth MC, Devoto A, Cui J, Stutius LM, Drummond EP, Ausubel FM
Plant J. 2000;24(2):205-18 - PMID: 11069695

Isolation and characterization of disease resistance gene homologues from rice cultivar IR64.

Ilag LL, Yadav RC, Huang N, Ronald PC, Ausubel FM
Gene. 2000;255(2):245-55 - PMID: 11024284

Simulation of fungal-mediated cell death by fumonisin B1 and selection of fumonisin B1-resistant (fbr) Arabidopsis mutants.

Stone JM, Heard JE, Asai T, Ausubel FM
Plant Cell. 2000;12(10):1811-22 - PMID: 11041878 - PMCID: PMC149121

The alternative sigma factor RpoN is required for hrp activity in Pseudomonas syringae pv. maculicola and acts at the level of hrpL transcription.

Hendrickson EL, Guevera P, Ausubel FM
J Bacteriol. 2000;182(12):3508-16 - PMID: 10852884 - PMCID: PMC101944

Virulence of the phytopathogen Pseudomonas syringae pv. maculicola is rpoN dependent.

Hendrickson EL, Guevera P, Peñaloza-Vàzquez A, Shao J, Bender C, Ausubel FM
J Bacteriol. 2000;182(12):3498-507 - PMID: 10852883 - PMCID: PMC101941

Mutational analysis of the Arabidopsis nucleotide binding site-leucine-rich repeat resistance gene RPS2.

Tao Y, Yuan F, Leister RT, Ausubel FM, Katagiri F
Plant Cell. 2000;12(12):2541-2554 - PMID: 11148296 - PMCID: PMC102236

Plants and animals share functionally common bacterial virulence factors.

Rahme LG, Ausubel FM, Cao H, Drenkard E, Goumnerov BC, Lau GW, Mahajan-Miklos S, Plotnikova J, Tan MW, Tsongalis J, Walendziewicz CL, Tompkins RG
Proc Natl Acad Sci U S A. 2000;97(16):8815-21 - PMID: 10922040 - PMCID: PMC34017

Salmonella typhimurium proliferates and establishes a persistent infection in the intestine of Caenorhabditis elegans.

Aballay A, Yorgey P, Ausubel FM
Curr Biol. 2000;10(23):1539-42 - PMID: 11114525

A simple procedure for the analysis of single nucleotide polymorphisms facilitates map-based cloning in Arabidopsis.

Drenkard E, Richter BG, Rozen S, Stutius LM, Angell NA, Mindrinos M, Cho RJ, Oefner PJ, Davis RW, Ausubel FM
Plant Physiol. 2000;124(4):1483-92 - PMID: 11115864 - PMCID: PMC1539302

Pathogenesis of the human opportunistic pathogen Pseudomonas aeruginosa PA14 in Arabidopsis.

Plotnikova JM, Rahme LG, Ausubel FM
Plant Physiol. 2000;124(4):1766-74 - PMID: 11115892 - PMCID: PMC59873

Arabidopsis genome. A milestone in plant biology.

Ausubel FM
Plant Physiol. 2000;124(4):1451-4 - PMID: 11115856 - PMCID: PMC1539293

In vitro selection and directed evolution.

Szostak JW
Harvey Lect. 2000;93:95-118 - PMID: 10941421

In vitro selection of functional nucleic acids.

Wilson DS, Szostak JW
Annu Rev Biochem. 2000;68:611-47 - PMID: 10872462

Constructing high complexity synthetic libraries of long ORFs using in vitro selection.

Cho G, Keefe AD, Liu R, Wilson DS, Szostak JW
J Mol Biol. 2000;297(2):309-19 - PMID: 10715203

Expanding the structural and functional diversity of RNA: analog uridine triphosphates as candidates for in vitro selection of nucleic acids.

Vaish NK, Fraley AW, Szostak JW, McLaughlin LW
Nucleic Acids Res. 2000;28(17):3316-22 - PMID: 10954600 - PMCID: PMC110695

Ribozyme-catalyzed tRNA aminoacylation.

Lee N, Bessho Y, Wei K, Szostak JW, Suga H
Nat Struct Biol. 2000;7(1):28-33 - PMID: 10625423

Optimized synthesis of RNA-protein fusions for in vitro protein selection.

Liu R, Barrick JE, Szostak JW, Roberts RW
Methods Enzymol. 2000;318:268-93 - PMID: 10889994

A bacterial two-hybrid selection system for studying protein-DNA and protein-protein interactions.

Joung JK, Ramm EI, Pabo CO
Proc Natl Acad Sci U S A. 2000;97(13):7382-7 - PMID: 10852947 - PMCID: PMC16554

Mechanisms of NSAID-induced gastrointestinal injury defined using mutant mice.

Beck PL, Xavier R, Lu N, Nanda NN, Dinauer M, Podolsky DK, Seed B
Gastroenterology. 2000;119(3):699-705 - PMID: 10982764

Episomal segregation of the adenovirus enhancer sequence by conditional genome rearrangement abrogates late viral gene expression.

Wang X, Zeng W, Murakawa M, Freeman MW, Seed B
J Virol. 2000;74(23):11296-303 - PMID: 11070029 - PMCID: PMC113234

Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule.

Holler N, Zaru R, Micheau O, Thome M, Attinger A, Valitutti S, Bodmer JL, Schneider P, Seed B, Tschopp J
Nat Immunol. 2000;1(6):489-95 - PMID: 11101870

What to do about high cholesterol

M Freeman, Consultant editor 2nd edition. PJ Skerret and SD Emond
President and Fellows of Harvard College. Harvard Health Publications. 2000;:ePub

Stromelysin-1 (MMP-3) expression driven by a macrophage-specific promoter results in reduced viability in transgenic mice.

Fabunmi RP, Moore KJ, Libby P, Freeman MW
Atherosclerosis. 2000;148(2):375-86 - PMID: 10657574

Lipopolysaccharide induces scavenger receptor A expression in mouse macrophages: a divergent response relative to human THP-1 monocyte/macrophages.

Fitzgerald ML, Moore KJ, Freeman MW, Reed GL
J Immunol. 2000;164(5):2692-700 - PMID: 10679110

Novel mutations in the gene encoding ATP-binding cassette 1 in four tangier disease kindreds.

Brousseau ME, Schaefer EJ, Dupuis J, Eustace B, Van Eerdewegh P, Goldkamp AL, Thurston LM, FitzGerald MG, Yasek-McKenna D, O'Neill G, Eberhart GP, Weiffenbach B, Ordovas JM, Freeman MW, Brown RH, Gu JZ
J Lipid Res. 2000;41(3):433-41 - PMID: 10706591

Cellular cholesterol efflux in heterozygotes for tangier disease is markedly reduced and correlates with high density lipoprotein cholesterol concentration and particle size.

Brousseau ME, Eberhart GP, Dupuis J, Asztalos BF, Goldkamp AL, Schaefer EJ, Freeman MW
J Lipid Res. 2000;41(7):1125-35 - PMID: 10884295

Divergent response to LPS and bacteria in CD14-deficient murine macrophages.

Moore KJ, Andersson LP, Ingalls RR, Monks BG, Li R, Arnaout MA, Golenbock DT, Freeman MW
J Immunol. 2000;165(8):4272-80 - PMID: 11035061

Episomal segregation of the adenovirus enhancer sequence by conditional genome rearrangement abrogates late viral gene expression.

Wang X, Zeng W, Murakawa M, Freeman MW, Seed B
J Virol. 2000;74(23):11296-303 - PMID: 11070029 - PMCID: PMC113234

Effects of overexpression of the amino-terminal fragment of apolipoprotein B on apolipoprotein B and lipoprotein production.

Li Z, Kako Y, Pang L, Freeman MW, Glick JM, Wang X, Goldberg IJ
J Lipid Res. 2000;41(12):1912-20 - PMID: 11108724

Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus.

Kurt-Jones EA, Popova L, Kwinn L, Haynes LM, Jones LP, Tripp RA, Walsh EE, Freeman MW, Golenbock DT, Anderson LJ, Finberg RW
Nat Immunol. 2000;1(5):398-401 - PMID: 11062499

Ancient adaptation of the active site of tryptophanyl-tRNA synthetase for tryptophan binding.

Praetorius-Ibba M, Stange-Thomann N, Kitabatake M, Ali K, Söll I, Carter CW, Ibba M, Söll D
Biochemistry. 2000;39(43):13136-43 - PMID: 11052665

A common muscarinic pathway for diapause recovery in the distantly related nematode species Caenorhabditis elegans and Ancylostoma caninum.

Tissenbaum HA, Hawdon J, Perregaux M, Hotez P, Guarente L, Ruvkun G
Proc Natl Acad Sci U S A. 2000;97(1):460-5 - PMID: 10618440 - PMCID: PMC26685

Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant.

Sze JY, Victor M, Loer C, Shi Y, Ruvkun G
Nature. 2000;403(6769):560-4 - PMID: 10676966

The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans.

Reinhart BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC, Rougvie AE, Horvitz HR, Ruvkun G
Nature. 2000;403(6772):901-6 - PMID: 10706289

The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor.

Slack FJ, Basson M, Liu Z, Ambros V, Horvitz HR, Ruvkun G
Mol Cell. 2000;5(4):659-69 - PMID: 10882102

DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells.

Nasrin N, Ogg S, Cahill CM, Biggs W, Nui S, Dore J, Calvo D, Shi Y, Ruvkun G, Alexander-Bridges MC
Proc Natl Acad Sci U S A. 2000;97(19):10412-7 - PMID: 10973497 - PMCID: PMC27038

Regulation of C. elegans life-span by insulinlike signaling in the nervous system.

Wolkow CA, Kimura KD, Lee MS, Ruvkun G
Science. 2000;290(5489):147-50 - PMID: 11021802

Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA.

Pasquinelli AE, Reinhart BJ, Slack F, Martindale MQ, Kuroda MI, Maller B, Hayward DC, Ball EE, Degnan B, Müller P, Spring J, Srinivasan A, Fishman M, Finnerty J, Corbo J, Levine M, Leahy P, Davidson E, Ruvkun G
Nature. 2000;408(6808):86-9 - PMID: 11081512

Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways.

Cahill CM, Tzivion G, Nasrin N, Ogg S, Dore J, Ruvkun G, Alexander-Bridges M
J Biol Chem. 2000;276(16):13402-10 - PMID: 11124266

Graded expression of ceh-14 reporters in the hypodermis is induced by a gonadal signal.

Kagoshima H, Sommer R, Reinhart BJ, Cassata G, Ruvkun G, Bürglin TR
Dev Genes Evol. 2000;210(11):564-9 - PMID: 11180807

Analysis of Arabidopsis glucose insensitive mutants, gin5 and gin6, reveals a central role of the plant hormone ABA in the regulation of plant vegetative development by sugar.

Arenas-Huertero F, Arroyo A, Zhou L, Sheen J, León P
Genes Dev. 2000;14(16):2085-96 - PMID: 10950871 - PMCID: PMC316855

Fumonisin B1-induced cell death in arabidopsis protoplasts requires jasmonate-, ethylene-, and salicylate-dependent signaling pathways.

Asai T, Stone JM, Heard JE, Kovtun Y, Yorgey P, Sheen J, Ausubel FM
Plant Cell. 2000;12(10):1823-36 - PMID: 11041879 - PMCID: PMC149122

The role of hexokinase in plant sugar signal transduction and growth and development.

Xiao W, Sheen J, Jang JC
Plant Mol Biol. 2000;44(4):451-61 - PMID: 11197321

A paradoxical reduction in susceptibility to colonic injury upon targeted transgenic ablation of goblet cells.

Itoh H, Beck PL, Inoue N, Xavier R, Podolsky DK
J Clin Invest. 1999;104(11):1539-47 - PMID: 10587517 - PMCID: PMC409855

Laser ablation of burns: initial clinical trial.

Sheridan RL, Lydon MM, Petras LM, Schomacker KT, Tompkins RG, Glatter RD, Parrish JA
Surgery. 1999;125(1):92-5 - PMID: 9889803

Acute hand burns in children: management and long-term outcome based on a 10-year experience with 698 injured hands.

Sheridan RL, Baryza MJ, Pessina MA, O'Neill KM, Cipullo HM, Donelan MB, Ryan CM, Schulz JT, Schnitzer JJ, Tompkins RG
Ann Surg. 1999;229(4):558-64 - PMID: 10203090 - PMCID: PMC1191743

Skin substitutes in burns.

Sheridan RL, Tompkins RG
Burns. 1999;25(2):97-103 - PMID: 10208382

A unique mechanism of desensitization to lipolysis mediated by beta(3)-adrenoceptor in rats with thermal injury.

Ikezu T, Yasuhara S, Granneman JG, Kraemer FB, Okamoto T, Tompkins RG, Martyn JA
Am J Physiol. 1999;277(2 Pt 1):E316-24 - PMID: 10444428

Cutaneous burn injury alters relative tricarboxylic acid cycle fluxes in rat liver.

Yarmush DM, MacDonald AD, Foy BD, Berthiaume F, Tompkins RG, Yarmush ML
J Burn Care Rehabil. 1999;20(4):292-302 - PMID: 10425591

Measurement of muscle protein synthesis by positron emission tomography with L-[methyl-11C]methionine: effects of transamination and transmethylation.

Carter EA, Yu YM, Alpert NM, Bonab AA, Tompkins RG, Fischman AJ
J Trauma. 1999;47(2):341-5 - PMID: 10452471

Low-dose inhaled nitric oxide in acutely burned children with profound respiratory failure.

Sheridan RL, Zapol WM, Ritz RH, Tompkins RG
Surgery. 1999;126(5):856-62 - PMID: 10568185

A 15-year experience with varicella infections in a pediatric burn unit.

Sheridan RL, Weber JM, Pasternak MM, Mulligan JM, Tompkins RG
Burns. 1999;25(4):353-6 - PMID: 10431985

The metabolic basis of the increase of the increase in energy expenditure in severely burned patients.

Yu YM, Tompkins RG, Ryan CM, Young VR
JPEN J Parenter Enteral Nutr. 1999;23(3):160-8 - PMID: 10338224

Pseudomonas aeruginosa killing of Caenorhabditis elegans used to identify P. aeruginosa virulence factors.

Tan MW, Rahme LG, Sternberg JA, Tompkins RG, Ausubel FM
Proc Natl Acad Sci U S A. 1999;96(5):2408-13 - PMID: 10051655 - PMCID: PMC26797

Genome-wide mapping with biallelic markers in Arabidopsis thaliana.

Cho RJ, Mindrinos M, Richards DR, Sapolsky RJ, Anderson M, Drenkard E, Dewdney J, Reuber TL, Stammers M, Federspiel N, Theologis A, Yang WH, Hubbell E, Au M, Chung EY, Lashkari D, Lemieux B, Dean C, Lipshutz RJ, Ausubel FM, Davis RW, Oefner PJ
Nat Genet. 1999;23(2):203-7 - PMID: 10508518

Arabidopsis thaliana PAD4 encodes a lipase-like gene that is important for salicylic acid signaling.

Jirage D, Tootle TL, Reuber TL, Frost LN, Feys BJ, Parker JE, Ausubel FM, Glazebrook J
Proc Natl Acad Sci U S A. 1999;96(23):13583-8 - PMID: 10557364 - PMCID: PMC23991

Isolation and characterization of fluorophore-binding RNA aptamers.

Holeman LA, Robinson SL, Szostak JW, Wilson C
Fold Des. 1999;3(6):423-31 - PMID: 9889155

Membrane compartmentation and the response to antigen.

Xavier R, Seed B
Curr Opin Immunol. 1999;11(3):265-9 - PMID: 10375560

The Epstein-Barr virus oncoprotein latent membrane protein 1 engages the tumor necrosis factor receptor-associated proteins TRADD and receptor-interacting protein (RIP) but does not induce apoptosis or require RIP for NF-kappaB activation.

Izumi KM, Cahir McFarland ED, Ting AT, Riley EA, Seed B, Kieff ED
Mol Cell Biol. 1999;19(8):5759-67 - PMID: 10409763 - PMCID: PMC84426

Regulated commitment of TNF receptor signaling: a molecular switch for death or activation.

Pimentel-Muiños FX, Seed B
Immunity. 1999;11(6):783-93 - PMID: 10626900

Leukotriene B4 receptor transgenic mice reveal novel protective roles for lipoxins and aspirin-triggered lipoxins in reperfusion.

Chiang N, Gronert K, Clish CB, O'Brien JA, Freeman MW, Serhan CN
J Clin Invest. 1999;104(3):309-16 - PMID: 10430612 - PMCID: PMC408424

Effluxed lipids: Tangier Island's latest export.

Freeman MW
Proc Natl Acad Sci U S A. 1999;96(20):10950-2 - PMID: 10500104 - PMCID: PMC34222

A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans.

Hobert O, Moerman DG, Clark KA, Beckerle MC, Ruvkun G
J Cell Biol. 1999;144(1):45-57 - PMID: 9885243 - PMCID: PMC2148118

The Caenorhabditis elegans lim-6 LIM homeobox gene regulates neurite outgrowth and function of particular GABAergic neurons.

Hobert O, Tessmar K, Ruvkun G
Development. 1999;126(7):1547-62 - PMID: 10068647

Pax genes in Caenorhabditis elegans: a new twist.

Hobert O, Ruvkun G
Trends Genet. 1999;15(6):214-6 - PMID: 10354580

A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans.

Paradis S, Ailion M, Toker A, Thomas JH, Ruvkun G
Genes Dev. 1999;13(11):1438-52 - PMID: 10364160 - PMCID: PMC316759

Alternative olfactory neuron fates are specified by the LIM homeobox gene lim-4.

Sagasti A, Hobert O, Troemel ER, Ruvkun G, Bargmann CI
Genes Dev. 1999;13(14):1794-806 - PMID: 10421632 - PMCID: PMC316880

Themes from a NASA workshop on gene regulatory processes in development and evolution.

Davidson EH, Ruvkun G
J Exp Zool. 1999;285(2):104-15 - PMID: 10440721

Molecular mechanisms of bacterial virulence elucidated using a Pseudomonas aeruginosa-Caenorhabditis elegans pathogenesis model.

Mahajan-Miklos S, Tan MW, Rahme LG, Ausubel FM
Cell. 1999;96(1):47-56 - PMID: 9989496

Killing of Caenorhabditis elegans by Pseudomonas aeruginosa used to model mammalian bacterial pathogenesis.

Tan MW, Mahajan-Miklos S, Ausubel FM
Proc Natl Acad Sci U S A. 1999;96(2):715-20 - PMID: 9892699 - PMCID: PMC15202

C4 GENE EXPRESSION.

Sheen J
Annu Rev Plant Physiol Plant Mol Biol. 1999;50():187-217 - PMID: 15012208

Health information in the developing world.

Lown B, Bukachi F, Xavier R
Lancet. 1998;352 Suppl 2:SII34-8 - PMID: 9798645

SEK1/MKK4 is required for maintenance of a normal peripheral lymphoid compartment but not for lymphocyte development.

Swat W, Fujikawa K, Ganiatsas S, Yang D, Xavier RJ, Harris NL, Davidson L, Ferrini R, Davis RJ, Labow MA, Flavell RA, Zon LI, Alt FW
Immunity. 1998;8(5):625-34 - PMID: 9620683

Characterization of a composite tissue model that supports clonal growth of human melanocytes in vitro and in vivo.

Medalie DA, Tompkins RG, Morgan JR
J Invest Dermatol. 1998;111(5):810-6 - PMID: 9804343

Genetically modified human keratinocytes overexpressing PDGF-A enhance the performance of a composite skin graft.

Eming SA, Medalie DA, Tompkins RG, Yarmush ML, Morgan JR
Hum Gene Ther. 1998;9(4):529-39 - PMID: 9525314

Objective estimates of the probability of death from burn injuries.

Ryan CM, Schoenfeld DA, Thorpe WP, Sheridan RL, Cassem EH, Tompkins RG
N Engl J Med. 1998;338(6):362-6 - PMID: 9449729

Maximal parenteral glucose oxidation in hypermetabolic young children: a stable isotope study.

Sheridan RL, Yu YM, Prelack K, Young VR, Burke JF, Tompkins RG
JPEN J Parenter Enteral Nutr. 1998;22(4):212-6 - PMID: 9661121

A rabbit model for metabolic studies after burn injury.

Hu RH, Yu YM, Costa D, Young VR, Ryan CM, Burke JF, Tompkins RG
J Surg Res. 1998;75(2):153-60 - PMID: 9655088

Death in the burn unit: sterile multiple organ failure.

Sheridan RL, Ryan CM, Yin LM, Hurley J, Tompkins RG
Burns. 1998;24(4):307-11 - PMID: 9688194

Muscle protein synthesis by positron-emission tomography with L-[methyl-11C]methionine in adult humans.

Fischman AJ, Yu YM, Livni E, Babich JW, Young VR, Alpert NM, Tompkins RG
Proc Natl Acad Sci U S A. 1998;95(22):12793-8 - PMID: 9788993 - PMCID: PMC23595

Both C3a and C3a(desArg) regulate interleukin-6 synthesis in human peripheral blood mononuclear cells.

Takabayashi T, Vannier E, Burke JF, Tompkins RG, Gelfand JA, Clark BD
J Infect Dis. 1998;177(6):1622-8 - PMID: 9607842

Modulation of expression of the ToxR regulon in Vibrio cholerae by a member of the two-component family of response regulators.

Wong SM, Carroll PA, Rahme LG, Ausubel FM, Calderwood SB
Infect Immun. 1998;66(12):5854-61 - PMID: 9826365 - PMCID: PMC108741

A light-independent developmental mechanism potentiates flavonoid gene expression in Arabidopsis seedlings.

Kubasek WL, Ausubel FM, Shirley BW
Plant Mol Biol. 1998;37(2):217-23 - PMID: 9617795

Use of Arabidopsis for genetic dissection of plant defense responses.

Glazebrook J, Rogers EE, Ausubel FM
Annu Rev Genet. 1998;31:547-69 - PMID: 9442907

The epidemiology of resistance to ofloxacin and oxacillin among clinical coagulase-negative staphylococcal isolates: analysis of risk factors and strain types.

Pegues DA, Colby C, Hibberd PL, Cohen LG, Ausubel FM, Calderwood SB, Hooper DC
Clin Infect Dis. 1998;26(1):72-9 - PMID: 9455512

Isolation of new Arabidopsis mutants with enhanced disease susceptibility to Pseudomonas syringae by direct screening.

Volko SM, Boller T, Ausubel FM
Genetics. 1998;149(2):537-48 - PMID: 9611172 - PMCID: PMC1460196

Use of cleaved amplified polymorphic sequences (CAPS) as genetic markers in Arabidopsis thaliana.

Glazebrook J, Drenkard E, Preuss D, Ausubel FM
Methods Mol Biol. 1998;82:173-82 - PMID: 9664424

Structural and kinetic characterization of an acyl transferase ribozyme.

Suga H, Lohse PA, Szostak JW
J Am Chem Soc. 1998;120(6):1151-6 - PMID: 11541113

Unusual metal ion catalysis in an acyl-transferase ribozyme.

Suga H, Cowan JA, Szostak JW
Biochemistry. 1998;37(28):10118-25 - PMID: 9665717

Isolation of a fluorophore-specific DNA aptamer with weak redox activity.

Wilson C, Szostak JW
Chem Biol. 1998;5(11):609-17 - PMID: 9831529

PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines.

Jiang C, Ting AT, Seed B
Nature. 1998;391(6662):82-6 - PMID: 9422509

Increased immune response elicited by DNA vaccination with a synthetic gp120 sequence with optimized codon usage.

André S, Seed B, Eberle J, Schraut W, Bültmann A, Haas J
J Virol. 1998;72(2):1497-503 - PMID: 9445053 - PMCID: PMC124631

Membrane compartmentation is required for efficient T cell activation.

Xavier R, Brennan T, Li Q, McCormack C, Seed B
Immunity. 1998;8(6):723-32 - PMID: 9655486

Muskelin, a novel intracellular mediator of cell adhesive and cytoskeletal responses to thrombospondin-1.

Adams JC, Seed B, Lawler J
EMBO J. 1998;17(17):4964-74 - PMID: 9724633 - PMCID: PMC1170825

PPARgamma and colorectal carcinoma: conflicts in a nuclear family.

Seed B
Nat Med. 1998;4(9):1004-5 - PMID: 9734386

Tumor induction of VEGF promoter activity in stromal cells.

Fukumura D, Xavier R, Sugiura T, Chen Y, Park EC, Lu N, Selig M, Nielsen G, Taksir T, Jain RK, Seed B
Cell. 1998;94(6):715-25 - PMID: 9753319

Decreased cholesterol efflux from fibroblasts of a patient without Tangier disease, but with markedly reduced high density lipoprotein cholesterol levels.

Eberhart GP, Mendez AJ, Freeman MW
J Clin Endocrinol Metab. 1998;83(3):836-46 - PMID: 9506737

Functional changes in scavenger receptor binding conformation are induced by charge mutants spanning the entire collagen domain.

Andersson L, Freeman MW
J Biol Chem. 1998;273(31):19592-601 - PMID: 9677385

In vitro-differentiated embryonic stem cell macrophages: a model system for studying atherosclerosis-associated macrophage functions.

Moore KJ, Fabunmi RP, Andersson LP, Freeman MW
Arterioscler Thromb Vasc Biol. 1998;18(10):1647-54 - PMID: 9763539

Temporal pattern formation by heterochronic genes.

Slack F, Ruvkun G
Annu Rev Genet. 1998;31:611-34 - PMID: 9442909

An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans.

Tissenbaum HA, Ruvkun G
Genetics. 1998;148(2):703-17 - PMID: 9504918 - PMCID: PMC1459840

Control of neural development and function in a thermoregulatory network by the LIM homeobox gene lin-11.

Hobert O, D'Alberti T, Liu Y, Ruvkun G
J Neurosci. 1998;18(6):2084-96 - PMID: 9482795

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor.

Paradis S, Ruvkun G
Genes Dev. 1998;12(16):2488-98 - PMID: 9716402 - PMCID: PMC317081

Aging, life span, and senescence.

Guarente L, Ruvkun G, Amasino R
Proc Natl Acad Sci U S A. 1998;95(19):11034-6 - PMID: 9736682 - PMCID: PMC33892

The taxonomy of developmental control in Caenorhabditis elegans.

Ruvkun G, Hobert O
Science. 1998;282(5396):2033-41 - PMID: 9851920

A novel repeat domain that is often associated with RING finger and B-box motifs.

Slack FJ, Ruvkun G
Trends Biochem Sci. 1998;23(12):474-5 - PMID: 9868369

The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway.

Ogg S, Ruvkun G
Mol Cell. 1998;2(6):887-93 - PMID: 9885576

Heterochronic genes in development and evolution.

Slack F, Ruvkun G
Biol Bull. 1998;195(3):375-6 - PMID: 9924779

A common theme for LIM homeobox gene function across phylogeny?

Hobert O, Ruvkun G
Biol Bull. 1998;195(3):377-80 - PMID: 9924780

Correlation of defense gene induction defects with powdery mildew susceptibility in Arabidopsis enhanced disease susceptibility mutants.

Reuber TL, Plotnikova JM, Dewdney J, Rogers EE, Wood W, Ausubel FM
Plant J. 1998;16(4):473-85 - PMID: 9881167

The role of proinflammatory cytokines in inflammatory and metabolic responses.

Tompkins RG
Ann Surg. 1997;225(3):243-5 - PMID: 9060578 - PMCID: PMC1190672

Differences in dermal analogs influence subsequent pigmentation, epidermal differentiation, basement membrane, and rete ridge formation of transplanted composite skin grafts.

Medalie DA, Eming SA, Collins ME, Tompkins RG, Yarmush ML, Morgan JR
Transplantation. 1997;64(3):454-65 - PMID: 9275113

Urinary urea nitrogen is imprecise as a predictor of protein balance in burned children.

Prelack K, Dwyer J, Yu YM, Sheridan RL, Tompkins RG
J Am Diet Assoc. 1997;97(5):489-95 - PMID: 9145086

Evaluation of acellular human dermis as a dermal analog in a composite skin graft.

Medalie DA, Tompkins RG, Morgan JR
ASAIO J. 1997;42(5):M455-62 - PMID: 8944923

Burns in children younger than two years of age: an experience with 200 consecutive admissions.

Sheridan RL, Ryan CM, Petras LM, Lydon MK, Weber JM, Tompkins RG
Pediatrics. 1997;100(4):721-3 - PMID: 9310533

Effect of burn injury on glucose and nitrogen metabolism in the liver: preliminary studies in a perfused liver system.

Yamaguchi Y, Yu YM, Zupke C, Yarmush DM, Berthiaume F, Tompkins RG, Yarmush ML
Surgery. 1997;121(3):295-303 - PMID: 9092130

TCA cycle flux estimates from NMR- and GC-MS-determined [13C]glutamate isotopomers in liver.

Vogt JA, Yarmush DM, Yu YM, Zupke C, Fischman AJ, Tompkins RG, Burke JF
Am J Physiol. 1997;272(6 Pt 1):C2049-62 - PMID: 9227434

Analysis of thermal injury-induced insulin resistance in rodents. Implication of postreceptor mechanisms.

Ikezu T, Okamoto T, Yonezawa K, Tompkins RG, Martyn JA
J Biol Chem. 1997;272(40):25289-95 - PMID: 9312146

Metabolic alterations in muscle of thermally injured rabbits, measured by positron emission tomography.

Carter EA, Tompkins RG, Hsu H, Christian B, Alpert NM, Weise S, Fischman AJ
Life Sci. 1997;61(1):39-44 - PMID: 9200667

Energy and protein provisions for thermally injured children revisited: an outcome-based approach for determining requirements.

Prelack K, Cunningham JJ, Sheridan RL, Tompkins RG
J Burn Care Rehabil. 1997;18(2):177-81; discussion 176 - PMID: 9095430

Localization of radiolabeled chemotactic peptide at focal sites of Escherichia coli infection in rabbits: evidence for a receptor-specific mechanism.

Babich JW, Tompkins RG, Graham W, Barrow SA, Fischman AJ
J Nucl Med. 1997;38(8):1316-22 - PMID: 9255175

Ice formation in isolated human hepatocytes and human liver tissue.

Bischof JC, Ryan CM, Tompkins RG, Yarmush ML, Toner M
ASAIO J. 1997;43(4):271-8 - PMID: 9242939

Control of hypertrophic scar growth using selective photothermolysis.

Reiken SR, Wolfort SF, Berthiaume F, Compton C, Tompkins RG, Yarmush ML
Lasers Surg Med. 1997;21(1):7-12 - PMID: 9228634

Interaction with autologous platelets multiplies interleukin-1 and tumor necrosis factor production in mononuclear cells.

Aiura K, Clark BD, Dinarello CA, Margolis NH, Kaplanski G, Burke JF, Tompkins RG, Gelfand JA
J Infect Dis. 1997;175(1):123-9 - PMID: 8985205

Nosocomial infections in pediatric patients with burns.

Weber JM, Sheridan RL, Pasternack MS, Tompkins RG
Am J Infect Control. 1997;25(3):195-201 - PMID: 9202814

Inhaled nitric oxide in burn patients with respiratory failure.

Sheridan RL, Hurford WE, Kacmarek RM, Ritz RH, Yin LM, Ryan CM, Tompkins RG
J Trauma. 1997;42(4):629-34 - PMID: 9137249

Inactivation of the alpha C protein antigen gene, bca, by a novel shuttle/suicide vector results in attenuation of virulence and immunity in group B Streptococcus.

Li J, Kasper DL, Ausubel FM, Rosner B, Michel JL
Proc Natl Acad Sci U S A. 1997;94(24):13251-6 - PMID: 9371832 - PMCID: PMC24295

Isolation of novel ribozymes that ligate AMP-activated RNA substrates.

Hager AJ, Szostak JW
Chem Biol. 1997;4(8):607-17 - PMID: 9281527

Introduction: Combinatorial Chemistry.

Szostak JW
Chem Rev. 1997;97(2):347-348 - PMID: 11848873

RNA-peptide fusions for the in vitro selection of peptides and proteins.

Roberts RW, Szostak JW
Proc Natl Acad Sci U S A. 1997;94(23):12297-302 - PMID: 9356443 - PMCID: PMC24913

Mutant ATP-binding RNA aptamers reveal the structural basis for ligand binding.

Dieckmann T, Butcher SE, Sassanfar M, Szostak JW, Feigon J
J Mol Biol. 1997;273(2):467-78 - PMID: 9344753

In vitro selection of catalytic RNAs.

Chapman KB, Szostak JW
Curr Opin Struct Biol. 1997;4:618-22 - PMID: 11539575

Domestic violence: old problems, new approaches.

Stuart LM
Links (Oxford). 1997;:4 - PMID: 12320799

Activation of prokaryotic transcription through arbitrary protein-protein contacts.

Dove SL, Joung JK, Hochschild A
Nature. 1997;386(6625):627-30 - PMID: 9121589

Integrins and inside-out signal transduction: converging signals from PKC and PIP3.

Kolanus W, Seed B
Curr Opin Cell Biol. 1997;9(5):725-31 - PMID: 9330877

Scavenger receptors in atherosclerosis.

Freeman MW
Curr Opin Hematol. 1997;4(1):41-7 - PMID: 9050378

A nuclear genetic lesion affecting Saccharomyces cerevisiae mitochondrial translation is complemented by a homologous Bacillus gene.

Kim SI, Stange-Thomann N, Martins O, Hong KW, Söll D, Fox TD
J Bacteriol. 1997;179(17):5625-7 - PMID: 9287027 - PMCID: PMC179443

VP16-activation of the C. elegans neural specification transcription factor UNC-86 suppresses mutations in downstream genes and causes defects in neural migration and axon outgrowth.

Sze JY, Liu Y, Ruvkun G
Development. 1997;124(6):1159-68 - PMID: 9102303

The Caenorhabditis elegans orphan nuclear hormone receptor gene nhr-2 functions in early embryonic development.

Sluder AE, Lindblom T, Ruvkun G
Dev Biol. 1997;184(2):303-19 - PMID: 9133437

Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 LIM homeobox gene.

Hobert O, Mori I, Yamashita Y, Honda H, Ohshima Y, Liu Y, Ruvkun G
Neuron. 1997;19(2):345-57 - PMID: 9292724

daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans.

Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G
Science. 1997;277(5328):942-6 - PMID: 9252323

The DAF-3 Smad protein antagonizes TGF-beta-related receptor signaling in the Caenorhabditis elegans dauer pathway.

Patterson GI, Koweek A, Wong A, Liu Y, Ruvkun G
Genes Dev. 1997;11(20):2679-90 - PMID: 9334330 - PMCID: PMC316611

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans.

Ogg S, Paradis S, Gottlieb S, Patterson GI, Lee L, Tissenbaum HA, Ruvkun G
Nature. 1997;389(6654):994-9 - PMID: 9353126

Arabidopsis enhanced disease susceptibility mutants exhibit enhanced susceptibility to several bacterial pathogens and alterations in PR-1 gene expression.

Rogers EE, Ausubel FM
Plant Cell. 1997;9(3):305-16 - PMID: 9090877 - PMCID: PMC156920

Phytoalexin-deficient mutants of Arabidopsis reveal that PAD4 encodes a regulatory factor and that four PAD genes contribute to downy mildew resistance.

Glazebrook J, Zook M, Mert F, Kagan I, Rogers EE, Crute IR, Holub EB, Hammerschmidt R, Ausubel FM
Genetics. 1997;146(1):381-92 - PMID: 9136026 - PMCID: PMC1207952

Use of model plant hosts to identify Pseudomonas aeruginosa virulence factors.

Rahme LG, Tan MW, Le L, Wong SM, Tompkins RG, Calderwood SB, Ausubel FM
Proc Natl Acad Sci U S A. 1997;94(24):13245-50 - PMID: 9371831 - PMCID: PMC24294

Paracoccidioidomycosis of bones and joints. A clinical, radiologic, and pathologic study of 9 cases.

Amstalden EM, Xavier R, Kattapuram SV, Bertolo MB, Swartz MN, Rosenberg AE
Medicine (Baltimore). 1996;75(4):213-25 - PMID: 8699961

Transgenic expression of tpr-met oncogene leads to development of mammary hyperplasia and tumors.

Liang TJ, Reid AE, Xavier R, Cardiff RD, Wang TC
J Clin Invest. 1996;97(12):2872-7 - PMID: 8675700 - PMCID: PMC507382

Effective postoperative protection for grafted posterior surfaces: the quilted dressing.

Sheridan RL, Behringer GE, Ryan CM, Bondoc CC, Quinby WC, Tompkins RG, Burke JF
J Burn Care Rehabil. 1996;16(6):607-9 - PMID: 8582939

Evaluation of human skin reconstituted from composite grafts of cultured keratinocytes and human acellular dermis transplanted to athymic mice.

Medalie DA, Eming SA, Tompkins RG, Yarmush ML, Krueger GG, Morgan JR
J Invest Dermatol. 1996;107(1):121-7 - PMID: 8752850

Planimetry study of the percent of body surface represented by the hand and palm: sizing irregular burns is more accurately done with the palm.

Sheridan RL, Petras L, Basha G, Salvo P, Cifrino C, Hinson M, McCabe M, Fallon J, Tompkins RG
J Burn Care Rehabil. 1996;16(6):605-6 - PMID: 8582938

Kinetics of plasma arginine and leucine in pediatric burn patients.

Yu YM, Sheridan RL, Burke JF, Chapman TE, Tompkins RG, Young VR
Am J Clin Nutr. 1996;64(1):60-6 - PMID: 8669415

Extracorporeal plasma perfusion of cultured hepatocytes: effect of intermittent perfusion on hepatocyte function and morphology.

Stefanovich P, Matthew HW, Toner M, Tompkins RG, Yarmush ML
J Surg Res. 1996;66(1):57-63 - PMID: 8954832

Management strategy in purpura fulminans with multiple organ failure in children.

Sheridan RL, Briggs SE, Remensnyder JP, Tompkins RG
Burns. 1996;22(1):53-6 - PMID: 8719318

Decreased cerebral glucose utilization in rats during the ebb phase of thermal injury.

Carter EA, Tompkins RG, Babich JW, Correia JA, Fischman AJ
J Trauma. 1996;40(6):930-5 - PMID: 8656479

Thermal injury in rats alters glucose utilization by skin, wound, and small intestine, but not by skeletal muscle.

Carter EA, Tompkins RG, Babich JW, Correia J, Bailey EM, Fischman AJ
Metabolism. 1996;45(9):1161-7 - PMID: 8781305

Accelerated healing and reduced need for grafting in pediatric patients with burns treated with arginine-glycine-aspartic acid peptide matrix. RGD Study Group.

Hansbrough JF, Herndon DN, Heimbach DM, Solem LD, Gamelli RL, Tompkins RG
J Burn Care Rehabil. 1996;16(4):377-87 - PMID: 8582916

Burn depth estimation by use of indocyanine green fluorescence: initial human trial.

Sheridan RL, Schomaker KT, Lucchina LC, Hurley J, Yin LM, Tompkins RG, Jerath M, Torri A, Greaves KW, Bua DP
J Burn Care Rehabil. 1996;16(6):602-4 - PMID: 8582937

Culture matrix configuration and composition in the maintenance of hepatocyte polarity and function.

Moghe PV, Berthiaume F, Ezzell RM, Toner M, Tompkins RG, Yarmush ML
Biomaterials. 1996;17(3):373-85 - PMID: 8745335

Recent clinical experience with cultured autologous epithelium.

Sheridan RL, Tompkins RG
Br J Plast Surg. 1996;49(1):72-4 - PMID: 8705108

Measurement of muscle protein synthesis by positron emission tomography with L-[methyl-11C]methionine.

Hsu H, Yu YM, Babich JW, Burke JF, Livni E, Tompkins RG, Young VR, Alpert NM, Fischman AJ
Proc Natl Acad Sci U S A. 1996;93(5):1841-6 - PMID: 8700846 - PMCID: PMC39869

Quantitative aspects of interorgan relationships among arginine and citrulline metabolism.

Yu YM, Burke JF, Tompkins RG, Martin R, Young VR
Am J Physiol. 1996;271(6 Pt 1):E1098-109 - PMID: 8997231

Comparative evaluation of the quantitative utilization of parenterally and enterally administered leucine and L-[1-13C,15N]leucine within the whole body and the splanchnic region.

Yu YM, Young VR, Tompkins RG, Burke JF
JPEN J Parenter Enteral Nutr. 1996;19(3):209-15 - PMID: 8551649

Candidemia in the pediatric patient with burns.

Sheridan RL, Weber JM, Budkevich LG, Tompkins RG
J Burn Care Rehabil. 1996;16(4):440-3 - PMID: 8582925

Control of hypertrophic scar growth using antibody-targeted photolysis.

Wolfort SF, Reiken SR, Berthiaume F, Tompkins RG, Yarmush ML
J Surg Res. 1996;62(1):17-22 - PMID: 8606503

Mode of action of the Arabidopsis thaliana phytoalexin camalexin and its role in Arabidopsis-pathogen interactions.

Rogers EE, Glazebrook J, Ausubel FM
Mol Plant Microbe Interact. 1996;9(8):748-57 - PMID: 8870273

Isolation of Arabidopsis genes that differentiate between resistance responses mediated by the RPS2 and RPM1 disease resistance genes.

Reuber TL, Ausubel FM
Plant Cell. 1996;8(2):241-9 - PMID: 8742710 - PMCID: PMC161094

Molecular recognition of pathogen attack occurs inside of plant cells in plant disease resistance specified by the Arabidopsis genes RPS2 and RPM1.

Leister RT, Ausubel FM, Katagiri F
Proc Natl Acad Sci U S A. 1996;93(26):15497-502 - PMID: 8986840 - PMCID: PMC26433

Use of cleaved amplified polymorphic sequences to distinguish strains of Staphylococcus epidermidis.

Calderwood SB, Baker MA, Carroll PA, Michel JL, Arbeit RD, Ausubel FM
J Clin Microbiol. 1996;34(11):2860-5 - PMID: 8897202 - PMCID: PMC229423

Differential mRNA display.

Reuber TL, Ausubel FM
Methods Cell Biol. 1996;49:431-40 - PMID: 8531774

Ribozymes: aiming at RNA replication and protein synthesis.

Hager AJ, Pollard JD, Szostak JW
Chem Biol. 1996;3(9):717-25 - PMID: 8939686

Kinetic and mechanistic analysis of nonenzymatic, template-directed oligoribonucleotide ligation.

Rohatgi R, Bartel DP, Szostak JW
J Am Chem Soc. 1996;118(14):3332-9 - PMID: 11539267

Ribozyme-catalysed amino-acid transfer reactions.

Lohse PA, Szostak JW
Nature. 1996;381(6581):442-4 - PMID: 8632803

Chance and necessity in the selection of nucleic acid catalysts.

Lorsch JR, Szostak JW
Acc Chem Res. 1996;29(2):103-10 - PMID: 11539421

A simple method for 3'-labeling of RNA.

Huang Z, Szostak JW
Nucleic Acids Res. 1996;24(21):4360-1 - PMID: 8932396 - PMCID: PMC146232

Nonenzymatic, template-directed ligation of oligoribonucleotides is highly regioselective for the formation of 3'-5' phosphodiester bonds.

Rohatgi R, Bartel DP, Szostak JW
J Am Chem Soc. 1996;118(14):3340-4 - PMID: 11539268

A soldier in respiratory distress.

Stuart LM, Rice PS, Lloyd G, Beale RJ
Lancet. 1996;347(8993):30 - PMID: 8531548

Deep inelastic scattering of polarized electrons by polarized 3He and the study of the neutron spin structure.

Anthony PL, Arnold RG, Band HR, Borel H, Bosted PE, Breton V, Cates GD, Chupp TE, Dietrich FS, Dunne J, Erbacher R, Fellbaum J, Fonvieille H, Gearhart R, Holmes R, Hughes EW, Johnson JR, Kawall D, Keppel C, Kuhn SE, Lombard-Nelsen RM, Marroncle J, Maruyama T, Meyer W, Meziani Z, Middleton H, Morgenstern J, Newbury NR, Petratos GG, Pitthan R, Prepost R, Roblin Y, Rock SE, Rokni SH, Shapiro G, Smith T, Souder PA, Spengos M, Staley F, Stuart LM, Szalata ZM, Terrien Y, Thompson AK, White JL, Woo ...
Phys Rev D Part Fields. 1996;54(11):6620-6650 - PMID: 10020671

(+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest.

Hung DT, Chen J, Schreiber SL
Chem Biol. 1996;3(4):287-93 - PMID: 8807856

Understanding and controlling the cell cycle with natural products.

Hung DT, Jamison TF, Schreiber SL
Chem Biol. 1996;3(8):623-39 - PMID: 8807895

Clustered syk tyrosine kinase domains trigger phagocytosis.

Greenberg S, Chang P, Wang DC, Xavier R, Seed B
Proc Natl Acad Sci U S A. 1996;93(3):1103-7 - PMID: 8577722 - PMCID: PMC40038

Codon usage limitation in the expression of HIV-1 envelope glycoprotein.

Haas J, Park EC, Seed B
Curr Biol. 1996;6(3):315-24 - PMID: 8805248

Alpha L beta 2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule.

Kolanus W, Nagel W, Schiller B, Zeitlmann L, Godar S, Stockinger H, Seed B
Cell. 1996;86(2):233-42 - PMID: 8706128

RIP mediates tumor necrosis factor receptor 1 activation of NF-kappaB but not Fas/APO-1-initiated apoptosis.

Ting AT, Pimentel-Muiños FX, Seed B
EMBO J. 1996;15(22):6189-96 - PMID: 8947041 - PMCID: PMC452440

Expression of the macrophage scavenger receptor, a multifunctional lipoprotein receptor, in microglia associated with senile plaques in Alzheimer's disease.

Christie RH, Freeman M, Hyman BT
Am J Pathol. 1996;148(2):399-403 - PMID: 8579103 - PMCID: PMC1861668

Substrate selection by aminoacyl-tRNA synthetases.

Ibba M, Thomann HU, Hong KW, Sherman JM, Weygand-Durasevic I, Sever S, Stange-Thomann N, Praetorius M, Söll D
Nucleic Acids Symp Ser. 1996;(33):40-2 - PMID: 8643392

Lineage-specific regulators couple cell lineage asymmetry to the transcription of the Caenorhabditis elegans POU gene unc-86 during neurogenesis.

Baumeister R, Liu Y, Ruvkun G
Genes Dev. 1996;10(11):1395-410 - PMID: 8647436

The Caenorhabditis elegans behavioral gene unc-24 encodes a novel bipartite protein similar to both erythrocyte band 7.2 (stomatin) and nonspecific lipid transfer protein.

Barnes TM, Jin Y, Horvitz HR, Ruvkun G, Hekimi S
J Neurochem. 1996;67(1):46-57 - PMID: 8667025

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans.

Morris JZ, Tissenbaum HA, Ruvkun G
Nature. 1996;382(6591):536-9 - PMID: 8700226

A bulged lin-4/lin-14 RNA duplex is sufficient for Caenorhabditis elegans lin-14 temporal gradient formation.

Ha I, Wightman B, Ruvkun G
Genes Dev. 1996;10(23):3041-50 - PMID: 8957004

Isolation of Arabidopsis mutants with enhanced disease susceptibility by direct screening.

Glazebrook J, Rogers EE, Ausubel FM
Genetics. 1996;143(2):973-82 - PMID: 8725243 - PMCID: PMC1207353

Effects of plasma exposure on cultured hepatocytes: Implications for bioartificial liver support.

Matthew HW, Sternberg J, Stefanovich P, Morgan JR, Toner M, Tompkins RG, Yarmush ML
Biotechnol Bioeng. 1996;51(1):100-11 - PMID: 18627093

Malignant epithelioid hemangioendothelioma of the tibia associated with a bone infarct in a patient who had Gaucher disease. A case report.

Pins MR, Mankin HJ, Xavier RJ, Rosenthal DI, Dickersin GR, Rosenberg AE
J Bone Joint Surg Am. 1995;77(5):777-81 - PMID: 7744904

Enzyme replacement therapy for Gaucher disease: skeletal responses to macrophage-targeted glucocerebrosidase.

Rosenthal DI, Doppelt SH, Mankin HJ, Dambrosia JM, Xavier RJ, McKusick KA, Rosen BR, Baker J, Niklason LT, Hill SC
Pediatrics. 1995;96(4 Pt 1):629-37 - PMID: 7567322

Atheroembolic renal failure after invasive procedures. Natural history based on 52 histologically proven cases.

Thadhani RI, Camargo CA, Xavier RJ, Fang LS, Bazari H
Medicine (Baltimore). 1995;74(6):350-8 - PMID: 7500898

Modified Stryker frame for intraoperative positioning of the patient with burns.

Sheridan RL, Hurley J, Lynch L, Balmer J, Ryan CM, Bondoc CC, Quinby WC, Tompkins RG, Burke JF
J Burn Care Rehabil. 1995;15(5):438-40 - PMID: 7995819

The burn unit as a resource for the management of acute nonburn conditions in children.

Sheridan RL, Briggs SE, Remensnyder JP, Gagnon SW, Doody DP, Ryan DP, Tompkins RG
J Burn Care Rehabil. 1995;16(1):62-4 - PMID: 7721912

Central venous catheter sepsis with weekly catheter change in paediatric burn patients: an analysis of 221 catheters.

Sheridan RL, Weber JM, Peterson HF, Tompkins RG
Burns. 1995;21(2):127-9 - PMID: 7766321

Permissive hypercapnia as a ventilatory strategy in burned children: effect on barotrauma, pneumonia, and mortality.

Sheridan RL, Kacmarek RM, McEttrick MM, Weber JM, Ryan CM, Doody DP, Ryan DP, Schnitzer JJ, Tompkins RG
J Trauma. 1995;39(5):854-9 - PMID: 7474000

Intraoperative reflectance oximetry in burn patients.

Sheridan RL, Prelack KM, Petras LM, Szyfelbein SK, Tompkins RG
J Clin Monit. 1995;11(1):32-4 - PMID: 7745451

Strategies for success in academic surgery.

Souba WW, Gamelli RL, Lorber MI, Thompson JS, Kron IL, Tompkins RG, Hoyt DB
Surgery. 1995;117(1):90-5 - PMID: 7809842

Relations among arginine, citrulline, ornithine, and leucine kinetics in adult burn patients.

Yu YM, Ryan CM, Burke JF, Tompkins RG, Young VR
Am J Clin Nutr. 1995;62(5):960-8 - PMID: 7572742

Postburn pancreatitis.

Ryan CM, Sheridan RL, Schoenfeld DA, Warshaw AL, Tompkins RG
Ann Surg. 1995;222(2):163-70 - PMID: 7543741 - PMCID: PMC1234774

Effects of malignancy and interleukin-2 infusion on gut macromolecular permeability.

Ryan CM, Atkins MB, Mier JW, Gelfand JA, Tompkins RG
Crit Care Med. 1995;23(11):1801-6 - PMID: 7587254

Retrovirus infection: effect of time and target cell number.

Morgan JR, LeDoux JM, Snow RG, Tompkins RG, Yarmush ML
J Virol. 1995;69(11):6994-7000 - PMID: 7474118 - PMCID: PMC189618

Detection of acute bacterial infection within soft tissue injuries using a 99mTc-labeled chemotactic peptide.

Fischman AJ, Babich JW, Barrow SA, Graham W, Carter E, Tompkins RG, Rubin RH
J Trauma. 1995;38(2):223-7 - PMID: 7869440

Plasma arginine and leucine kinetics and urea production rates in burn patients.

Yu YM, Young VR, Castillo L, Chapman TE, Tompkins RG, Ryan CM, Burke JF
Metabolism. 1995;44(5):659-66 - PMID: 7752916

Cultured autologous epithelium in patients with burns of ninety percent or more of the body surface.

Sheridan RL, Tompkins RG
J Trauma. 1995;38(1):48-50 - PMID: 7745657

Percutaneous cholecystostomy in the critically ill burn patient.

Sheridan RL, Ryan CM, Lee MJ, Mueller PR, Tompkins RG
J Trauma. 1995;38(2):248-51 - PMID: 7869446

Dynamics of photoinduced cell plasma membrane injury.

Thorpe WP, Toner M, Ezzell RM, Tompkins RG, Yarmush ML
Biophys J. 1995;68(5):2198-206 - PMID: 7612864 - PMCID: PMC1282125

Dynamics of cell membrane permeability changes at supraphysiological temperatures.

Bischof JC, Padanilam J, Holmes WH, Ezzell RM, Lee RC, Tompkins RG, Yarmush ML, Toner M
Biophys J. 1995;68(6):2608-14 - PMID: 7647264 - PMCID: PMC1282171

Genetically modified human epidermis overexpressing PDGF-A directs the development of a cellular and vascular connective tissue stroma when transplanted to athymic mice--implications for the use of genetically modified keratinocytes to modulate dermal regeneration.

Eming SA, Lee J, Snow RG, Tompkins RG, Yarmush ML, Morgan JR
J Invest Dermatol. 1995;105(6):756-63 - PMID: 7490468

Effects of hypothermia on the function, membrane integrity, and cytoskeletal structure of hepatocytes.

Stefanovich P, Ezzell RM, Sheehan SJ, Tompkins RG, Yarmush ML, Toner M
Cryobiology. 1995;32(4):389-403 - PMID: 7656572

A device to measure the oxygen uptake rate of attached cells: importance in bioartificial organ design.

Foy BD, Rotem A, Toner M, Tompkins RG, Yarmush ML
Cell Transplant. 1995;3(6):515-27 - PMID: 7881763

The acutely burned hand: management and outcome based on a ten-year experience with 1047 acute hand burns.

Sheridan RL, Hurley J, Smith MA, Ryan CM, Bondoc CC, Quinby WC, Tompkins RG, Burke JF
J Trauma. 1995;38(3):406-11 - PMID: 7897728

Emergency management of major hydrofluoric acid exposures.

Sheridan RL, Ryan CM, Quinby WC, Blair J, Tompkins RG, Burke JF
Burns. 1995;21(1):62-4 - PMID: 7718123

Midazolam infusion in pediatric patients with burns who are undergoing mechanical ventilation.

Sheridan RL, McEttrick M, Bacha G, Stoddard F, Tompkins RG
J Burn Care Rehabil. 1995;15(6):515-8 - PMID: 7852455

Solid organ procurement from burn patients.

Sheridan RL, Stewart B, Tompkins RG
J Trauma. 1995;38(5):824-5 - PMID: 7760420

Clinical experience with the use of biodegradable tacks in pediatric patients with burns.

Sheridan RL, Petras L, Basha G, Tompkins RG
J Burn Care Rehabil. 1995;16(2 Pt 1):143-4 - PMID: 7775509

Molecular genetics of plant disease resistance.

Staskawicz BJ, Ausubel FM, Baker BJ, Ellis JG, Jones JD
Science. 1995;268(5211):661-7 - PMID: 7732374

Analysis of Arabidopsis mutants deficient in flavonoid biosynthesis.

Shirley BW, Kubasek WL, Storz G, Bruggemann E, Koornneef M, Ausubel FM, Goodman HM
Plant J. 1995;8(5):659-71 - PMID: 8528278

Use of Arabidopsis thaliana defense-related mutants to dissect the plant response to pathogens.

Ausubel FM, Katagiri F, Mindrinos M, Glazebrook J
Proc Natl Acad Sci U S A. 1995;92(10):4189-96 - PMID: 7753782 - PMCID: PMC41909

A DNA metalloenzyme with DNA ligase activity.

Cuenoud B, Szostak JW
Nature. 1995;375(6532):611-4 - PMID: 7791880

Isolation of a ribozyme with 5'-5' ligase activity.

Chapman KB, Szostak JW
Chem Biol. 1995;2(5):325-33 - PMID: 9383434

Structurally complex and highly active RNA ligases derived from random RNA sequences.

Ekland EH, Szostak JW, Bartel DP
Science. 1995;269(5222):364-70 - PMID: 7618102

Total chemical synthesis of a ribozyme derived from a group I intron.

Whoriskey SK, Usman N, Szostak JW
Proc Natl Acad Sci U S A. 1995;92(7):2465-9 - PMID: 7708666 - PMCID: PMC42238

Reverse transcriptase reads through a 2'-5'linkage and a 2'-thiophosphate in a template.

Lorsch JR, Bartel DP, Szostak JW
Nucleic Acids Res. 1995;23(15):2811-4 - PMID: 7544885 - PMCID: PMC307115

Kinetic and thermodynamic characterization of the reaction catalyzed by a polynucleotide kinase ribozyme.

Lorsch JR, Szostak JW
Biochemistry. 1995;34(46):15315-27 - PMID: 7578148

A DNA aptamer that binds adenosine and ATP.

Huizenga DE, Szostak JW
Biochemistry. 1995;34(2):656-65 - PMID: 7819261

In vitro evolution of a self-alkylating ribozyme.

Wilson C, Szostak JW
Nature. 1995;374(6525):777-82 - PMID: 7723823

RNA aptamers that bind flavin and nicotinamide redox cofactors.

Lauhon CT, Szostak JW
J Am Chem Soc. 1995;117(4):1246-57 - PMID: 11539282

Genetic strategy for analyzing specificity of dimer formation: Escherichia coli cyclic AMP receptor protein mutant altered in its dimerization specificity.

Joung JK, Chung EH, King G, Yu C, Hirsh AS, Hochschild A
Genes Dev. 1995;9(23):2986-96 - PMID: 7498794

Nonreceptor tyrosine kinases in aggregation-mediated cell activation.

Seed B, Kolanus W, Romeo C, Xavier R
Adv Exp Med Biol. 1995;365:111-9 - PMID: 7887297

Initiation of signal transduction by receptor aggregation: role of nonreceptor tyrosine kinases.

Seed B
Semin Immunol. 1995;7(1):3-11 - PMID: 7612893

RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death.

Stanger BZ, Leder P, Lee TH, Kim E, Seed B
Cell. 1995;81(4):513-23 - PMID: 7538908

Developments in expression cloning.

Seed B
Curr Opin Biotechnol. 1995;6(5):567-73 - PMID: 7579669

PSGL-1 recognition of P-selectin is controlled by a tyrosine sulfation consensus at the PSGL-1 amino terminus.

Pouyani T, Seed B
Cell. 1995;83(2):333-43 - PMID: 7585950

The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination.

Li Z, Otevrel T, Gao Y, Cheng HL, Seed B, Stamato TD, Taccioli GE, Alt FW
Cell. 1995;83(7):1079-89 - PMID: 8548796

Screening for hyperlipidemia. In: Goroll A, May L, Mulley A, eds

Haydock GS and MW Freeman
1995. 1995;Primary Care Medicine, 3rd Edit:72-75

Regulation of smooth muscle cell scavenger receptor expression in vivo by atherogenic diets and in vitro by cytokines.

Li H, Freeman MW, Libby P
J Clin Invest. 1995;95(1):122-33 - PMID: 7814605 - PMCID: PMC295387

Structure of the murine macrophage scavenger receptor gene and evaluation of sequences that regulate expression in the macrophage cell line, P388D.

Aftring RP, Freeman MW
J Lipid Res. 1995;36(6):1305-14 - PMID: 7666008

Common virulence factors for bacterial pathogenicity in plants and animals.

Rahme LG, Stevens EJ, Wolfort SF, Shao J, Tompkins RG, Ausubel FM
Science. 1995;268(5219):1899-902 - PMID: 7604262

The activity of cytochrome P450IA1 in stable cultured rat hepatocytes.

Rotem A, Matthew HW, Hsiao PH, Toner M, Tompkins RG, Yarmush ML
Toxicol In Vitro. 1995;9(2):139-49 - PMID: 20650073

Feedback control of gene expression.

Sheen J
Photosynth Res. 1994;39(3):427-38 - PMID: 24311134

Control of methicillin-resistant Staphylococcus aureus in a pediatric burn unit.

Sheridan RL, Weber J, Benjamin J, Pasternack MS, Tompkins RG
Am J Infect Control. 1994;22(6):340-5 - PMID: 7695112

Human recombinant interleukin-1 receptor antagonist in the treatment of sepsis syndrome.

Tompkins RG
Crit Care Med. 1994;22(1):3 - PMID: 8124969

Staphylococcal toxic shock syndrome in a paediatric burn unit.

Bacha EA, Sheridan RL, Donohue GA, Tompkins RG
Burns. 1994;20(6):499-502 - PMID: 7880413

Prognostic significance of prehospital cardiac or pulmonary resuscitation in paediatric burns patients.

Sheridan RL, Tompkins RG
Burns. 1994;20(3):265-6 - PMID: 8054145

Rapid quantitation of recombinant retroviruses.

Morgan JR, Lee J, Tompkins RG, Yarmush ML
Biotechnol Prog. 1994;10(4):441-6 - PMID: 7765097

Antibody Targeted Photolysis.

Yarmush ML, Thorpe WP, Strong L, Rakestraw SL, Toner M, Tompkins RG
Crit Rev Ther Drug Carrier Syst. 1994;10(3):197-252 - PMID: 8258158

Management of burn wounds with prompt excision and immediate closure.

Sheridan RL, Tompkins RG, Burke JF
J Intensive Care Med. 1994;9(1):6-17 - PMID: 10146651

Transport of fluorescent dextrans across the rat ileum after cutaneous thermal injury.

Berthiaume F, Ezzell RM, Toner M, Yarmush ML, Tompkins RG
Crit Care Med. 1994;22(3):455-64 - PMID: 7510222

Nitric oxide production is intensely and persistently increased in tissue by thermal injury.

Carter EA, Derojas-Walker T, Tamir S, Tannenbaum SR, Yu YM, Tompkins RG
Biochem J. 1994;304 ( Pt 1):201-4 - PMID: 7528006 - PMCID: PMC1137472

Arterial blood pressure immediately after thermal injury: the role of anesthesia.

Trop M, Carter EA, Schiffrin EJ, Tompkins RG
J Burn Care Rehabil. 1994;15(3):224-31 - PMID: 8056811

Additive effects of thermal injury and infection on gut permeability.

Ryan CM, Bailey SH, Carter EA, Schoenfeld DA, Tompkins RG
Arch Surg. 1994;129(3):325-8 - PMID: 8129610

Injury-induced inhibition of fat absorption.

Carter EA, Tompkins RG
J Burn Care Rehabil. 1994;15(2):154-7 - PMID: 8195256

Thermal injury induces very early production of interleukin-1 alpha in the rat by mechanisms other than endotoxemia.

Mester M, Carter EA, Tompkins RG, Gelfand JA, Dinarello CA, Burke JF, Clark BD
Surgery. 1994;115(5):588-96 - PMID: 8178258

A quantitative model of invasive Pseudomonas infection in burn injury.

Stevens EJ, Ryan CM, Friedberg JS, Barnhill RL, Yarmush ML, Tompkins RG
J Burn Care Rehabil. 1994;15(3):232-5 - PMID: 8056812

The use of pentafluorophenyl derivatives for the 18F labelling of proteins.

Herman LW, Fischman AJ, Tompkins RG, Hanson RN, Byon C, Strauss HW, Elmaleh DR
Nucl Med Biol. 1994;21(7):1005-10 - PMID: 9234356

Synthesis of 2-[18F]fluoro-2-deoxy-L-glucose and positron emission tomography studies in monkeys.

Meng J, Elmaleh DR, Jyawook S, Weiss S, Alpert NM, Babich JW, Tompkins RG, Fischman AJ
Nucl Med Biol. 1994;21(4):633-40 - PMID: 9234321

Antisense DNA delivery in vivo: liver targeting by receptor-mediated uptake.

Lu XM, Fischman AJ, Jyawook SL, Hendricks K, Tompkins RG, Yarmush ML
J Nucl Med. 1994;35(2):269-75 - PMID: 8294998

Antibody-targeted photolysis of bacteria in vivo.

Berthiaume F, Reiken SR, Toner M, Tompkins RG, Yarmush ML
Biotechnology (N Y). 1994;12(7):703-6 - PMID: 7764916

Assessment of artificial liver support technology.

Yarmush ML, Dunn JC, Tompkins RG
Cell Transplant. 1994;1(5):323-41 - PMID: 1344305

Long-term functional recovery of hepatocytes after cryopreservation in a three-dimensional culture configuration.

Borel Rinkes IH, Toner M, Sheeha SJ, Tompkins RG, Yarmush ML
Cell Transplant. 1994;1(4):281-92 - PMID: 1344301

An extracorporeal microscopy perfusion chamber for on-line studies of environmental effects on cultured hepatocytes.

Borel Rinkes IH, Toner M, Tompkins RG, Yarmush ML
J Biomech Eng. 1994;116(2):135-9 - PMID: 8078319

Selective adhesion of hepatocytes on patterned surfaces.

Bhatia SN, Toner M, Tompkins RG, Yarmush ML
Ann N Y Acad Sci. 1994;745:187-209 - PMID: 7832508

A general model for analysis of the tricarboxylic acid cycle with use of [13C]glutamate isotopomer measurements.

Vogt JA, Fischman AJ, Kempf M, Yu YM, Tompkins RG, Burke JF
Am J Physiol. 1994;266(6 Pt 1):E1012-22 - PMID: 7912892

Prophylactic antibiotics and their role in the prevention of surgical wound infection.

Sheridan RL, Tompkins RG, Burke JF
Adv Surg. 1994;27:43-65 - PMID: 8140979

Intracompartmental sepsis in burn patients.

Sheridan RL, Tompkins RG, McManus WF, Pruitt BA
J Trauma. 1994;36(3):301-5 - PMID: 8145308

Effectiveness of poloxamer 188 in arresting calcein leakage from thermally damaged isolated skeletal muscle cells.

Padanilam JT, Bischof JC, Lee RC, Cravalho EG, Tompkins RG, Yarmush ML, Toner M
Ann N Y Acad Sci. 1994;720:111-23 - PMID: 7516633

Femoral arterial catheterization in paediatric burn patients.

Sheridan RL, Weber JM, Tompkins RG
Burns. 1994;20(5):451-2 - PMID: 7999277

Cellular distribution of endotoxin after injection of chemically purified lipopolysaccharide differs from that after injection of live bacteria.

Ge Y, Ezzell RM, Tompkins RG, Warren HS
J Infect Dis. 1994;169(1):95-104 - PMID: 8277203

Haplotypic divergence coupled with lack of diversity at the Arabidopsis thaliana alcohol dehydrogenase locus: roles for both balancing and directional selection?

Hanfstingl U, Berry A, Kellogg EA, Costa JT, Rüdiger W, Ausubel FM
Genetics. 1994;138(3):811-28 - PMID: 7851777 - PMCID: PMC1206230

In vitro evolution of new ribozymes with polynucleotide kinase activity.

Lorsch JR, Szostak JW
Nature. 1994;371(6492):31-6 - PMID: 7521014

Suppression of mutations in the core of the Tetrahymena ribozyme by spermidine, ethanol and by substrate stabilization.

Hanna M, Szostak JW
Nucleic Acids Res. 1994;22(24):5326-31 - PMID: 7816622 - PMCID: PMC332078

Evidence that the guanosine substrate of the Tetrahymena ribozyme is bound in the anti conformation and that N7 contributes to binding.

Lin CW, Hanna M, Szostak JW
Biochemistry. 1994;33(9):2703-7 - PMID: 8117735

1H NMR studies of the high-affinity Rev binding site of the Rev responsive element of HIV-1 mRNA: base pairing in the core binding element.

Peterson RD, Bartel DP, Szostak JW, Horvath SJ, Feigon J
Biochemistry. 1994;33(18):5357-66 - PMID: 8180157

In vitro genetic analysis of the hinge region between helical elements P5-P4-P6 and P7-P3-P8 in the sunY group I self-splicing intron.

Green R, Szostak JW
J Mol Biol. 1994;235(1):140-55 - PMID: 7507168

In vitro selection of RNA aptamers specific for cyanocobalamin.

Lorsch JR, Szostak JW
Biochemistry. 1994;33(4):973-82 - PMID: 7508262

Measurements of the electric and magnetic form factors of the proton from Q2=1.75 to 8.83 (GeV/c)2.

Andivahis L, Bosted PE, Lung A, Stuart LM, Alster J, Arnold RG, Chang CC, Dietrich FS, Dodge W, Gearhart R, Gomez J, Griffioen KA, Hicks RS, Hyde-Wright CE, Keppel C, Kuhn SE, Lichtenstadt J, Miskimen RA, Peterson GA, Petratos GG, Rock SE, Rokni S, Sakumoto WK, Spengos M, Swartz K, Szalata Z, Tao LH
Phys Rev D Part Fields. 1994;50(9):5491-5517 - PMID: 10018207

Synergistic activation of transcription by bacteriophage lambda cI protein and E. coli cAMP receptor protein.

Joung JK, Koepp DM, Hochschild A
Science. 1994;265(5180):1863-6 - PMID: 8091212

Distinct binding and cellular properties of synthetic (+)- and (-)-discodermolides.

Hung DT, Nerenberg JB, Schreiber SL
Chem Biol. 1994;1(1):67-71 - PMID: 9383372

4A11, a monoclonal antibody recognizing a novel antigen expressed on aberrant vascular endothelium. Upregulation in an in vivo model of contact dermatitis.

Koch AE, Nickoloff BJ, Holgersson J, Seed B, Haines GK, Burrows JC, Leibovich SJ
Am J Pathol. 1994;144(2):244-59 - PMID: 8311112 - PMCID: PMC1887152

Association of Raf with the CD3 delta and gamma chains of the T cell receptor-CD3 complex.

Loh C, Romeo C, Seed B, Bruder JT, Rapp U, Rao A
J Biol Chem. 1994;269(12):8817-25 - PMID: 8132616

Making agonists of antagonists.

Seed B
Chem Biol. 1994;1(3):125-9 - PMID: 9383381

Of mice, men and cholesterol

Aftring RP and MW Freeman
Hepatology. 1994;19:1054-1056

Macrophage scavenger receptors

MW Freeman
Current Opinions in Lipidology . 1994;5:143-148

Macrophage scavenger receptors.

Freeman MW
Curr Opin Lipidol. 1994;5(2):143-8 - PMID: 8044417

Of mice, men and cholesterol.

Aftring RP, Freeman MW
Hepatology. 1994;19(4):1054-6 - PMID: 8138246

A point mutation in Euglena gracilis chloroplast tRNA(Glu) uncouples protein and chlorophyll biosynthesis.

Stange-Thomann N, Thomann HU, Lloyd AJ, Lyman H, Söll D
Proc Natl Acad Sci U S A. 1994;91(17):7947-51 - PMID: 8058739 - PMCID: PMC44521

daf-2, daf-16 and daf-23: genetically interacting genes controlling Dauer formation in Caenorhabditis elegans.

Gottlieb S, Ruvkun G
Genetics. 1994;137(1):107-20 - PMID: 8056303 - PMCID: PMC1205929

Targeted mutations in the Caenorhabditis elegans POU homeo box gene ceh-18 cause defects in oocyte cell cycle arrest, gonad migration, and epidermal differentiation.

Greenstein D, Hird S, Plasterk RH, Andachi Y, Kohara Y, Wang B, Finney M, Ruvkun G
Genes Dev. 1994;8(16):1935-48 - PMID: 7958868

Programmed cell death in plants: a pathogen-triggered response activated coordinately with multiple defense functions.

Greenberg JT, Guo A, Klessig DF, Ausubel FM
Cell. 1994;77(4):551-63 - PMID: 8187175

Isolation of phytoalexin-deficient mutants of Arabidopsis thaliana and characterization of their interactions with bacterial pathogens.

Glazebrook J, Ausubel FM
Proc Natl Acad Sci U S A. 1994;91(19):8955-9 - PMID: 8090752 - PMCID: PMC44725

The A. thaliana disease resistance gene RPS2 encodes a protein containing a nucleotide-binding site and leucine-rich repeats.

Mindrinos M, Katagiri F, Yu GL, Ausubel FM
Cell. 1994;78(6):1089-99 - PMID: 7923358

Oxygen is a factor determining in vitro tissue assembly: Effects on attachment and spreading of hepatocytes.

Rotem A, Toner M, Bhatia S, Foy BD, Tompkins RG, Yarmush ML
Biotechnol Bioeng. 1994;43(7):654-60 - PMID: 18615765

Engineering organ perfusion protocols: NMR analysis of hepatocyte isolation from perfused rat liver.

Foy BD, Toner M, Tompkins RG, Yarmush ML
Biotechnol Bioeng. 1994;43(7):661-72 - PMID: 18615766

Peroxynitrite-induced rat colitis--a new model of colonic inflammation.

Rachmilewitz D, Stamler JS, Karmeli F, Mullins ME, Singel DJ, Loscalzo J, Xavier RJ, Podolsky DK
Gastroenterology. 1993;105(6):1681-8 - PMID: 8253344

Flavobacterial sepsis in massively burned pediatric patients.

Sheridan RL, Ryan CM, Pasternack MS, Weber JM, Tompkins RG
Clin Infect Dis. 1993;17(2):185-7 - PMID: 8399864

Dishwasher effluent burns in infants.

Sheridan RL, Sheridan MG, Tompkins RG
Pediatrics. 1993;91(1):142-4 - PMID: 8416479

Hepatocytes from rat liver perfusions. Physicochemical effects on polyribosome size.

Dunn JC, Friedberg JS, Tompkins RG, Yarmush ML
ASAIO J. 1993;38(4):841-5 - PMID: 1450483

An effective technique of scrotal harvest.

Sheridan RL, Ryan CM, Tompkins RG
J Burn Care Rehabil. 1993;14(5):557-8 - PMID: 8245111

Gut macromolecular permeability in pancreatitis correlates with severity of disease in rats.

Ryan CM, Schmidt J, Lewandrowski K, Compton CC, Rattner DW, Warshaw AL, Tompkins RG
Gastroenterology. 1993;104(3):890-5 - PMID: 8440440

Burn wound closure using permanent skin replacement materials.

Tompkins RG, Burke JF
World J Surg. 1993;16(1):47-52 - PMID: 1290266

Isolation and long-term culture of human hepatocytes.

Ryan CM, Carter EA, Jenkins RL, Sterling LM, Yarmush ML, Malt RA, Tompkins RG
Surgery. 1993;113(1):48-54 - PMID: 8417488

In vivo bioactivity and biodistribution of chemotactic peptide analogs in nonhuman primates.

Fischman AJ, Rauh D, Solomon H, Babich JW, Tompkins RG, Kroon D, Strauss HW, Rubin RH
J Nucl Med. 1993;34(12):2130-4 - PMID: 8254400

Technetium-99m-labeled chemotactic peptides: comparison with indium-111-labeled white blood cells for localizing acute bacterial infection in the rabbit.

Babich JW, Graham W, Barrow SA, Dragotakes SC, Tompkins RG, Rubin RH, Fischman AJ
J Nucl Med. 1993;34(12):2176-81 - PMID: 8254406

Absence of change in hepatic lactate metabolism after burn injury.

Carter EA, Khalid MA, Burke JF, Tompkins RG
Burns. 1993;19(6):475-8 - PMID: 8292229

Core body temperature responses immediately after cutaneous thermal injury in rats.

Trop M, Tompkins RG, Schiffrin EJ, Carter EA, Burke JF
J Burn Care Rehabil. 1993;13(6):632-8 - PMID: 1469027

Thermal injury-induced changes in the rat intestine brush border cytoskeleton.

Ezzell RM, Carter EA, Yarmush ML, Tompkins RG
Surgery. 1993;114(3):591-7 - PMID: 8367816

Proline-mediated enhancement of hepatocyte function in a collagen gel sandwich culture configuration.

Lee J, Morgan JR, Tompkins RG, Yarmush ML
FASEB J. 1993;7(6):586-91 - PMID: 8472895

Intestinal production of interleukin-1 alpha during endotoxemia in the mouse.

Mester M, Tompkins RG, Gelfand JA, Dinarello CA, Burke JF, Clark BD
J Surg Res. 1993;54(6):584-91 - PMID: 8412068

Nucleation and growth of ice crystals inside cultured hepatocytes during freezing in the presence of dimethyl sulfoxide.

Karlsson JO, Cravalho EG, Borel Rinkes IH, Tompkins RG, Yarmush ML, Toner M
Biophys J. 1993;65(6):2524-36 - PMID: 8312489 - PMCID: PMC1225995

Acute adrenal insufficiency in the burn intensive care unit.

Sheridan RL, Ryan CM, Tompkins RG
Burns. 1993;19(1):63-6 - PMID: 8435119

Nonequilibrium freezing of one-cell mouse embryos. Membrane integrity and developmental potential.

Toner M, Cravalho EG, Stachecki J, Fitzgerald T, Tompkins RG, Yarmush ML, Armant DR
Biophys J. 1993;64(6):1908-21 - PMID: 8369414 - PMCID: PMC1262525

Immobilized IL-2 preserves the viability of an IL-2 dependent cell line.

Horwitz JI, Toner M, Tompkins RG, Yarmush ML
Mol Immunol. 1993;30(11):1041-8 - PMID: 8350874

Technetium-99m-labeled hydrazino nicotinamide derivatized chemotactic peptide analogs for imaging focal sites of bacterial infection.

Babich JW, Solomon H, Pike MC, Kroon D, Graham W, Abrams MJ, Tompkins RG, Rubin RH, Fischman AJ
J Nucl Med. 1993;34(11):1964-74 - PMID: 8229242

Effect of collagen gel configuration on the cytoskeleton in cultured rat hepatocytes.

Ezzell RM, Toner M, Hendricks K, Dunn JC, Tompkins RG, Yarmush ML
Exp Cell Res. 1993;208(2):442-52 - PMID: 8375473

Signal transduction mutants of Arabidopsis uncouple nuclear CAB and RBCS gene expression from chloroplast development.

Susek RE, Ausubel FM, Chory J
Cell. 1993;74(5):787-99 - PMID: 7690685

Arabidopsis mutants compromised for the control of cellular damage during pathogenesis and aging.

Greenberg JT, Ausubel FM
Plant J. 1993;4(2):327-41 - PMID: 8220484

An Arabidopsis thaliana lipoxygenase gene can be induced by pathogens, abscisic acid, and methyl jasmonate.

Melan MA, Dong X, Endara ME, Davis KR, Ausubel FM, Peterman TK
Plant Physiol. 1993;101(2):441-50 - PMID: 7506426 - PMCID: PMC160590

An RNA motif that binds ATP.

Sassanfar M, Szostak JW
Nature. 1993;364(6437):550-3 - PMID: 7687750

Ribozyme-catalyzed primer extension by trinucleotides: a model for the RNA-catalyzed replication of RNA.

Doudna JA, Usman N, Szostak JW
Biochemistry. 1993;32(8):2111-5 - PMID: 7680575

Isolation of new ribozymes from a large pool of random sequences [see comment].

Bartel DP, Szostak JW
Science. 1993;261(5127):1411-8 - PMID: 7690155

Ribozymes. Evolution ex vivo.

Szostak JW
Nature. 1993;361(6408):119-20 - PMID: 7678448

Measurements of the electric and magnetic form factors of the neutron from Q2=1.75 to 4.00 (GeV/c)2.

Lung A, Stuart LM, Bosted PE, Andivahis L, Alster J, Arnold RG, Chang CC, Dietrich FS, Dodge WR, Gearhart R, Gomez J, Griffioen KA, Hicks RS, Hyde-Wright CE, Keppel C, Kuhn SE, Lichtenstadt J, Miskimen RA, Peterson GA, Petratos GG, Rock SE, Rokni SH, Sakumoto WK, Spengos M, Swartz K, Szalata Z, Tao LH
Phys Rev Lett. 1993;70(6):718-721 - PMID: 10054186

Determination of the neutron spin structure function.

Anthony PL, Arnold RG, Band HR, Borel H, Bosted PE, Breton V, Cates GD, Chupp TE, Dietrich FS, Dunne J, Erbacher R, Fellbaum J, Fonvieille H, Gearhart R, Holmes R, Hughes EW, Johnson JR, Kawall D, Keppel C, Kuhn SE, Lombard-Nelsen RM, Marroncle J, Maruyama T, Meyer W, Meziani Z, Middleton H, Morgenstern J, Newbury NR, Petratos GG, Pitthan R, Prepost R, Roblin Y, Rock SE, Rokni SH, Shapiro G, Smith T, Souder PA, Spengos M, Staley F, Stuart LM, Szalata ZM, Terrien Y, Thompson AK, White JL, Woo ...
Phys Rev Lett. 1993;71(7):959-962 - PMID: 10055413

Synergistic activation of transcription by Escherichia coli cAMP receptor protein.

Joung JK, Le LU, Hochschild A
Proc Natl Acad Sci U S A. 1993;90(7):3083-7 - PMID: 7681995 - PMCID: PMC46241

Thrombin receptor structure and function.

Coughlin SR, Scarborough RM, Vu TK, Hung DT
Cold Spring Harb Symp Quant Biol. 1993;57:149-54 - PMID: 1339654

Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: roles of calcineurin binding and cellular location.

Bram RJ, Hung DT, Martin PK, Schreiber SL, Crabtree GR
Mol Cell Biol. 1993;13(8):4760-9 - PMID: 7687744 - PMCID: PMC360102

Activation of immune system effector function by T-cell or Fc receptor intracellular domains.

Romeo C, Kolanus W, Amiot M, Seed B
Cold Spring Harb Symp Quant Biol. 1993;57:117-25 - PMID: 1339650

Antiviral effects of different CD4-immunoglobulin constructs against HIV-1 and SIV: immunological characterization, pharmacokinetic data and in vivo experiments.

Langner KD, Niedrig M, Fultz P, Anderson D, Reiner G, Repke H, Gelderblom H, Seed B, Hilfenhaus J, Zettlmeissl G
Arch Virol. 1993;130(1-2):157-70 - PMID: 8503781

T cell activation by clustered tyrosine kinases.

Kolanus W, Romeo C, Seed B
Cell. 1993;74(1):171-83 - PMID: 8334702

What to do about high cholesterol

M Freeman, Consultant editor. PJ Skerret and SD Emond
President and Fellows of Harvard College. Harvard Health Publications. 1993;:ePub

Postmenopausal hormone-replacement therapy

Martin KA, and Freeman MW
New Engl J Med. 1993;328:1115-1117

Ascorbic acid oxidation product(s) protect human low density lipoprotein against atherogenic modification. Anti- rather than prooxidant activity of vitamin C in the presence of transition metal ions.

Retsky KL, Freeman MW, Frei B
J Biol Chem. 1993;268(2):1304-9 - PMID: 8419332

Postmenopausal hormone-replacement therapy.

Martin KA, Freeman MW
N Engl J Med. 1993;328(15):1115-7 - PMID: 8455670

Surface expression of human CD14 in Chinese hamster ovary fibroblasts imparts macrophage-like responsiveness to bacterial endotoxin.

Golenbock DT, Liu Y, Millham FH, Freeman MW, Zoeller RA
J Biol Chem. 1993;268(29):22055-9 - PMID: 7691822

Structures and high and low affinity ligand binding properties of murine type I and type II macrophage scavenger receptors.

Ashkenas J, Penman M, Vasile E, Acton S, Freeman M, Krieger M
J Lipid Res. 1993;34(6):983-1000 - PMID: 8394868

Characterization of cloned PTH/PTHrP receptors.

Segre GV, Abou-Samra AB, Jüppner H, Schipani E, Force T, Urena P, Freeman M, Kong XF, Kolakowski LF, Hock J
J Endocrinol Invest. 1993;15(9 Suppl 6):11-7 - PMID: 1338633

Cell signalling. A molecular growth industry.

Ruvkun G
Nature. 1993;360(6406):711-2 - PMID: 1334532

The Caenorhabditis elegans homeobox gene cluster.

Bürglin TR, Ruvkun G
Curr Opin Genet Dev. 1993;3(4):615-20 - PMID: 7902148

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans.

Wightman B, Ha I, Ruvkun G
Cell. 1993;75(5):855-62 - PMID: 8252622

A procedure for mapping Arabidopsis mutations using co-dominant ecotype-specific PCR-based markers.

Konieczny A, Ausubel FM
Plant J. 1993;4(2):403-10 - PMID: 8106085

Arabidopsis mutations at the RPS2 locus result in loss of resistance to Pseudomonas syringae strains expressing the avirulence gene avrRpt2.

Yu GL, Katagiri F, Ausubel FM
Mol Plant Microbe Interact. 1993;6(4):434-43 - PMID: 8400373

Dynamics of transcriptional and translational processes in hepatocytes cultured in a collagen sandwich.

Dunn JC, Tompkins RG, Yarmush ML
Biotechnol Bioeng. 1993;41(5):593-8 - PMID: 18609591

Optimization of hepatocyte attachment to microcarriers: Importance of oxygen.

Foy BD, Lee J, Morgan J, Toner M, Tompkins RG, Yarmush ML
Biotechnol Bioeng. 1993;42(5):579-88 - PMID: 18613079

LONG-TERM FUNCTIONAL RECOVERY OF HEPATOCYTES AFTER CRYOPRESERVATION IN A THREE-DIMENSIONAL CULTURE CONFIGURATION.

Borel Rinkes IH, Mehmet T, Sheehan SJ, Tompkins RG, Yarmush ML
Cell Transplant. 1992;1(4):281-292 - PMID: 28148377

Value of the history and stool occult blood test in selection of patients for upper endoscopy in Zimbabwe.

Xavier RJ, Stein CM, Kiire CF, Arrow J, Kitai I
East Afr Med J. 1992;69(5):268-71 - PMID: 1644046

Separation and quantitation of polyethylene glycols 400 and 3350 from human urine by high-performance liquid chromatography.

Ryan CM, Yarmush ML, Tompkins RG
J Pharm Sci. 1992;81(4):350-2 - PMID: 1501072

Fulminant hepatic failure treated with anti-endotoxin antibody.

Tompkins RG
Crit Care Med. 1992;20(11):1507 - PMID: 1424690

Antibody-targeted photolysis: in vitro immunological, photophysical, and cytotoxic properties of monoclonal antibody-dextran-Sn(IV) chlorin e6 immunoconjugates.

Rakestraw SL, Ford WE, Tompkins RG, Rodgers MA, Thorpe WP, Yarmush ML
Biotechnol Prog. 1992;8(1):30-9 - PMID: 1371392

Spatial distribution of tumor-specific monoclonal antibodies in human melanoma xenografts.

Shockley TR, Lin K, Nagy JA, Tompkins RG, Yarmush ML, Dvorak HF
Cancer Res. 1992;52(2):367-76 - PMID: 1728408

Hepatocytes in collagen sandwich: evidence for transcriptional and translational regulation.

Dunn JC, Tompkins RG, Yarmush ML
J Cell Biol. 1992;116(4):1043-53 - PMID: 1734019 - PMCID: PMC2289333

A quantitative analysis of tumor specific monoclonal antibody uptake by human melanoma xenografts: effects of antibody immunological properties and tumor antigen expression levels.

Shockley TR, Lin K, Sung C, Nagy JA, Tompkins RG, Dedrick RL, Dvorak HF, Yarmush ML
Cancer Res. 1992;52(2):357-66 - PMID: 1728407

Circulating interleukin-1 beta and tumor necrosis factor-alpha concentrations after burn injury in humans.

Cannon JG, Friedberg JS, Gelfand JA, Tompkins RG, Burke JF, Dinarello CA
Crit Care Med. 1992;20(10):1414-9 - PMID: 1395662

Increased transcellular permeability of rat small intestine after thermal injury.

Carter EA, Gonnella A, Tompkins RG
Burns. 1992;18(2):117-20 - PMID: 1590925

Hepatic tissue engineering. Development of critical technologies.

Yarmush ML, Toner M, Dunn JC, Rotem A, Hubel A, Tompkins RG
Ann N Y Acad Sci. 1992;665:238-52 - PMID: 1416606

Intracellular ice formation during the freezing of hepatocytes cultured in a double collagen gel.

Hubel A, Toner M, Cravalho EG, Yarmush ML, Tompkins RG
Biotechnol Prog. 1992;7(6):554-9 - PMID: 1367755

Sn-chlorin e6 antibacterial immunoconjugates. An in vitro and in vivo analysis.

Lu XM, Fischman AJ, Stevens E, Lee TT, Strong L, Tompkins RG, Yarmush ML
J Immunol Methods. 1992;156(1):85-99 - PMID: 1431166

Effects of dimethyl sulfoxide on cultured rat hepatocytes in sandwich configuration.

Borel Rinkes IH, Toner M, Ezzell RM, Tompkins RG, Yarmush ML
Cryobiology. 1992;29(4):443-53 - PMID: 1395682

Increased gut permeability early after burns correlates with the extent of burn injury.

Ryan CM, Yarmush ML, Burke JF, Tompkins RG
Crit Care Med. 1992;20(11):1508-12 - PMID: 1424691

A stable long-term hepatocyte culture system for studies of physiologic processes: cytokine stimulation of the acute phase response in rat and human hepatocytes.

Bader A, Borel Rinkes IH, Closs EI, Ryan CM, Toner M, Cunningham JM, Tompkins RG, Yarmush ML
Biotechnol Prog. 1992;8(3):219-25 - PMID: 1368259

Regulation of Flavonoid Biosynthetic Genes in Germinating Arabidopsis Seedlings.

Kubasek WL, Shirley BW, McKillop A, Goodman HM, Briggs W, Ausubel FM
Plant Cell. 1992;4(10):1229-1236 - PMID: 12297632 - PMCID: PMC160210

Large, identical, tandem repeating units in the C protein alpha antigen gene, bca, of group B streptococci.

Michel JL, Madoff LC, Olson K, Kling DE, Kasper DL, Ausubel FM
Proc Natl Acad Sci U S A. 1992;89(21):10060-4 - PMID: 1438195 - PMCID: PMC50277

The central domain of Rhizobium leguminosarum DctD functions independently to activate transcription.

Huala E, Stigter J, Ausubel FM
J Bacteriol. 1992;174(4):1428-31 - PMID: 1735730 - PMCID: PMC206444

Meiotic recombination on artificial chromosomes in yeast.

Ross LO, Treco D, Nicolas A, Szostak JW, Dawson D
Genetics. 1992;131(3):541-50 - PMID: 1385793 - PMCID: PMC1205028

A strategy for the generation of conditional mutations by protein destabilization.

Park EC, Finley D, Szostak JW
Proc Natl Acad Sci U S A. 1992;89(4):1249-52 - PMID: 1311090 - PMCID: PMC48426

In vitro genetics.

Szostak JW
Trends Biochem Sci. 1992;17(3):89-93 - PMID: 1384177

Selection of a ribozyme that functions as a superior template in a self-copying reaction.

Green R, Szostak JW
Science. 1992;258(5090):1910-5 - PMID: 1470913

Selection in vitro of single-stranded DNA molecules that fold into specific ligand-binding structures.

Ellington AD, Szostak JW
Nature. 1992;355(6363):850-2 - PMID: 1538766

ARD1 and NAT1 proteins form a complex that has N-terminal acetyltransferase activity.

Park EC, Szostak JW
EMBO J. 1992;11(6):2087-93 - PMID: 1600941 - PMCID: PMC556675

Measurements of the electric and magnetic form factors of the proton from Q2=1.75 to 8.83 (GeV/c)2.

Bosted PE, Andivahis L, Lung A, Stuart LM, Alster J, Arnold RG, Chang CC, Dietrich FS, Dodge W, Gearhart R, Gomez J, Griffioen KA, Hicks RS, Hyde-Wright CE, Keppel C, Kuhn SE, Lichtenstadt J, Miskimen RA, Peterson GA, Petratos GG, Rock SE, Rokni S, Sakumoto WK, Spengos M, Swartz K, Szalata Z, Tao LH
Phys Rev Lett. 1992;68(26):3841-3844 - PMID: 10045818

Measurements of nu W2 and R= sigma L/ sigma T from inelastic electron-aluminum scattering near x=1.

Bosted PE, Lung A, Andivahis L, Stuart LM, Alster J, Arnold RG, Chang CC, Dietrich FS, Dodge W, Gearhart R, Gomez J, Griffioen KA, Hicks RS, Hyde-Wright CE, Keppel C, Kuhn SE, Lichtenstadt J, Miskimen RA, Peterson GA, Petratos GG, Rock SE, Rokni S, Sakumoto WK, Spengos M, Swartz K, Szalata Z, Tao LH
Phys Rev C Nucl Phys. 1992;46(6):2505-2515 - PMID: 9968381

Expression cloning and characterization of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation.

Coughlin SR, Vu TK, Hung DT, Wheaton VI
Semin Thromb Hemost. 1992;18(2):161-6 - PMID: 1321504

Thrombin-induced events in non-platelet cells are mediated by the unique proteolytic mechanism established for the cloned platelet thrombin receptor.

Hung DT, Vu TH, Nelken NA, Coughlin SR
J Cell Biol. 1992;116(3):827-32 - PMID: 1309820 - PMCID: PMC2289317

Characterization of a functional thrombin receptor. Issues and opportunities.

Coughlin SR, Vu TK, Hung DT, Wheaton VI
J Clin Invest. 1992;89(2):351-5 - PMID: 1310691 - PMCID: PMC442859

"Mirror image" antagonists of thrombin-induced platelet activation based on thrombin receptor structure.

Hung DT, Vu TK, Wheaton VI, Charo IF, Nelken NA, Esmon N, Esmon CT, Coughlin SR
J Clin Invest. 1992;89(2):444-50 - PMID: 1310695 - PMCID: PMC442871

Cloned platelet thrombin receptor is necessary for thrombin-induced platelet activation.

Hung DT, Vu TK, Wheaton VI, Ishii K, Coughlin SR
J Clin Invest. 1992;89(4):1350-3 - PMID: 1313452 - PMCID: PMC442997

HLA-A2-peptide complexes: refolding and crystallization of molecules expressed in Escherichia coli and complexed with single antigenic peptides.

Garboczi DN, Hung DT, Wiley DC
Proc Natl Acad Sci U S A. 1992;89(8):3429-33 - PMID: 1565634 - PMCID: PMC48881

cDNA cloning of a human 25 kDa FK506 and rapamycin binding protein.

Hung DT, Schreiber SL
Biochem Biophys Res Commun. 1992;184(2):733-8 - PMID: 1374240

Tethered ligand agonist peptides. Structural requirements for thrombin receptor activation reveal mechanism of proteolytic unmasking of agonist function.

Scarborough RM, Naughton MA, Teng W, Hung DT, Rose J, Vu TK, Wheaton VI, Turck CW, Coughlin SR
J Biol Chem. 1992;267(19):13146-9 - PMID: 1320011

The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase.

Hung DT, Wong YH, Vu TK, Coughlin SR
J Biol Chem. 1992;267(29):20831-4 - PMID: 1328213

Molecular cloning of a cDNA encoding CD34, a sialomucin of human hematopoietic stem cells.

Simmons DL, Satterthwaite AB, Tenen DG, Seed B
J Immunol. 1992;148(1):267-71 - PMID: 1370171

Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin's disease.

Dürkop H, Latza U, Hummel M, Eitelbach F, Seed B, Stein H
Cell. 1992;68(3):421-7 - PMID: 1310894

Sequence requirements for induction of cytolysis by the T cell antigen/Fc receptor zeta chain.

Romeo C, Amiot M, Seed B
Cell. 1992;68(5):889-97 - PMID: 1547489

Cloning and functional expression of the T cell activation antigen CD26.

Tanaka T, Camerini D, Seed B, Torimoto Y, Dang NH, Kameoka J, Dahlberg HN, Schlossman SF, Morimoto C
J Immunol. 1992;149(2):481-6 - PMID: 1352530

Marked by a mucin.

Seed B
Curr Biol. 1992;2(9):457-9 - PMID: 15335892

Lineage-independent activation of immune system effector function by myeloid Fc receptors.

Kolanus W, Romeo C, Seed B
EMBO J. 1992;11(13):4861-8 - PMID: 1464313 - PMCID: PMC556962

Rabbit aortic smooth muscle cells express inducible macrophage scavenger receptor messenger RNA that is absent from endothelial cells.

Bickel PE, Freeman MW
J Clin Invest. 1992;90(4):1450-7 - PMID: 1401078 - PMCID: PMC443191

Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium.

Abou-Samra AB, Jüppner H, Force T, Freeman MW, Kong XF, Schipani E, Urena P, Richards J, Bonventre JV, Potts JT
Proc Natl Acad Sci U S A. 1992;89(7):2732-6 - PMID: 1313566 - PMCID: PMC48736

Intron excision from tRNA precursors by plant splicing endonuclease requires unique features of the mature tRNA domain.

Stange N, Beier D, Beier H
Eur J Biochem. 1992;210(1):193-203 - PMID: 1332859

Dominant gain-of-function mutations that lead to misregulation of the C. elegans heterochronic gene lin-14, and the evolutionary implications of dominant mutations in pattern-formation genes.

Ruvkun G, Wightman B, Bürglin T, Arasu P
Dev Suppl. 1992;1:47-54 - PMID: 1742500

C. elegans unc-4 gene encodes a homeodomain protein that determines the pattern of synaptic input to specific motor neurons.

Miller DM, Shen MM, Shamu CE, Bürglin TR, Ruvkun G, Dubois ML, Ghee M, Wilson L
Nature. 1992;355(6363):841-5 - PMID: 1347150

New motif in PBX genes.

Bürglin TR, Ruvkun G
Nat Genet. 1992;1(5):319-20 - PMID: 1363814

Regulation of the mec-3 gene by the C.elegans homeoproteins UNC-86 and MEC-3.

Xue D, Finney M, Ruvkun G, Chalfie M
EMBO J. 1992;11(13):4969-79 - PMID: 1361171 - PMCID: PMC556975

Cloning the Arabidopsis GA1 Locus by Genomic Subtraction.

Sun T, Goodman HM, Ausubel FM
Plant Cell. 1992;4(2):119-128 - PMID: 12297643 - PMCID: PMC160113

copia-like retrotransposons are ubiquitous among plants.

Voytas DF, Cummings MP, Koniczny A, Ausubel FM, Rodermel SR
Proc Natl Acad Sci U S A. 1992;89(15):7124-8 - PMID: 1379734 - PMCID: PMC49658

The importance of proline on long-term hepatocyte function in a collagen gel sandwich configuration: regulation of protein secretion.

Lee J, Morgan JR, Tompkins RG, Yarmush ML
Biotechnol Bioeng. 1992;40(2):298-305 - PMID: 18601116

Oxygen uptake rates in cultured rat hepatocytes.

Rotem A, Toner M, Tompkins RG, Yarmush ML
Biotechnol Bioeng. 1992;40(10):1286-91 - PMID: 18601082

Preparation and characterization of immunoconjugates for antibody-targeted photolysis.

Rakestraw SL, Tompkins RG, Yarmush ML
Bioconjug Chem. 1991;1(3):212-21 - PMID: 1710935

Penetration of tumor tissue by antibodies and other immunoproteins.

Shockley TR, Lin K, Nagy JA, Tompkins RG, Dvorak HF, Yarmush ML
Ann N Y Acad Sci. 1991;618:367-82 - PMID: 2006796

Cryopreservation of isolated hepatocytes: intracellular ice formation under various chemical and physical conditions.

Harris CL, Toner M, Hubel A, Cravalho EG, Yarmush ML, Tompkins RG
Cryobiology. 1991;28(5):436-44 - PMID: 1752131

Antibody-targeted photolysis. Bacteriocidal effects of Sn (IV) chlorin e6-dextran-monoclonal antibody conjugates.

Friedberg JS, Tompkins RG, Rakestraw SL, Warren SW, Fischman AJ, Yarmush ML
Ann N Y Acad Sci. 1991;618:383-93 - PMID: 1706578

Imaging infections with antibodies. A method to localize occult infections.

Tompkins RG, Fischman AJ, Yarmush ML
Chest. 1991;100(3 Suppl):169S-172S - PMID: 1909225

Progress in burn treatment and the use of artificial skin.

Tompkins RG, Burke JF
World J Surg. 1991;14(6):819-24 - PMID: 2256353

Quantitative analysis of blood vessel permeability of squirrel monkeys.

Tompkins RG
Am J Physiol. 1991;260(4 Pt 2):H1194-204 - PMID: 2012223

Long-term in vitro function of adult hepatocytes in a collagen sandwich configuration.

Dunn JC, Tompkins RG, Yarmush ML
Biotechnol Prog. 1991;7(3):237-45 - PMID: 1367596

A superfamily of Arabidopsis thaliana retrotransposons.

Konieczny A, Voytas DF, Cummings MP, Ausubel FM
Genetics. 1991;127(4):801-9 - PMID: 1709409 - PMCID: PMC1204407

The centromere region of Arabidopsis thaliana chromosome 1 contains telomere-similar sequences.

Richards EJ, Goodman HM, Ausubel FM
Nucleic Acids Res. 1991;19(12):3351-7 - PMID: 1648204 - PMCID: PMC328334

Aerobic inactivation of Rhizobium meliloti NifA in Escherichia coli is mediated by lon and two newly identified genes, snoB and snoC.

Huala E, Moon AL, Ausubel FM
J Bacteriol. 1991;173(1):382-90 - PMID: 1846139 - PMCID: PMC207197

Differential induction of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase genes in Arabidopsis thaliana by wounding and pathogenic attack.

Keith B, Dong XN, Ausubel FM, Fink GR
Proc Natl Acad Sci U S A. 1991;88(19):8821-5 - PMID: 1681544 - PMCID: PMC52602

High intensity and blue light regulated expression of chimeric chalcone synthase genes in transgenic Arabidopsis thaliana plants.

Feinbaum RL, Storz G, Ausubel FM
Mol Gen Genet. 1991;226(3):449-56 - PMID: 2038307

Nodules elicited by Rhizobium meliloti heme mutants are arrested at an early stage of development.

Dickstein R, Scheirer DC, Fowle WH, Ausubel FM
Mol Gen Genet. 1991;230(3):423-32 - PMID: 1766439

Cloned alpha and beta C-protein antigens of group B streptococci elicit protective immunity.

Michel JL, Madoff LC, Kling DE, Kasper DL, Ausubel FM
Infect Immun. 1991;59(6):2023-8 - PMID: 1674738 - PMCID: PMC257960

Template-directed primer extension catalyzed by the Tetrahymena ribozyme.

Bartel DP, Doudna JA, Usman N, Szostak JW
Mol Cell Biol. 1991;11(6):3390-4 - PMID: 2038341 - PMCID: PMC360195

A multisubunit ribozyme that is a catalyst of and template for complementary strand RNA synthesis.

Doudna JA, Couture S, Szostak JW
Science. 1991;251(5001):1605-8 - PMID: 1707185

Mutations in a semiconserved region of the Tetrahymena intron.

Pace U, Szostak JW
FEBS Lett. 1991;280(1):171-4 - PMID: 2009960

Synthesis of RNA containing inosine: analysis of the sequence requirements for the 5' splice site of the Tetrahymena group I intron.

Green R, Szostak JW, Benner SA, Rich A, Usman N
Nucleic Acids Res. 1991;19(15):4161-6 - PMID: 1714564 - PMCID: PMC328556

Genetic and physical analyses of sister chromatid exchange in yeast meiosis.

Sun H, Dawson D, Szostak JW
Mol Cell Biol. 1991;11(12):6328-36 - PMID: 1944292 - PMCID: PMC361828

HIV-1 Rev regulation involves recognition of non-Watson-Crick base pairs in viral RNA.

Bartel DP, Zapp ML, Green MR, Szostak JW
Cell. 1991;67(3):529-36 - PMID: 1934059

A poly(dA.dT) tract is a component of the recombination initiation site at the ARG4 locus in Saccharomyces cerevisiae.

Schultes NP, Szostak JW
Mol Cell Biol. 1991;11(1):322-8 - PMID: 1986228 - PMCID: PMC359622

Extensive 3'-overhanging, single-stranded DNA associated with the meiosis-specific double-strand breaks at the ARG4 recombination initiation site.

Sun H, Treco D, Szostak JW
Cell. 1991;64(6):1155-61 - PMID: 2004421

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation.

Vu TK, Hung DT, Wheaton VI, Coughlin SR
Cell. 1991;64(6):1057-68 - PMID: 1672265

Domains specifying thrombin-receptor interaction.

Vu TK, Wheaton VI, Hung DT, Charo I, Coughlin SR
Nature. 1991;353(6345):674-7 - PMID: 1717851

The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells.

Stamenkovic I, Aruffo A, Amiot M, Seed B
EMBO J. 1991;10(2):343-8 - PMID: 1991450 - PMCID: PMC452652

Cellular immunity to HIV activated by CD4 fused to T cell or Fc receptor polypeptides.

Romeo C, Seed B
Cell. 1991;64(5):1037-46 - PMID: 1900456

The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins.

Aruffo A, Melnick MB, Linsley PS, Seed B
J Exp Med. 1991;174(4):949-52 - PMID: 1919444 - PMCID: PMC2118957

CD62/P-selectin recognition of myeloid and tumor cell sulfatides.

Aruffo A, Kolanus W, Walz G, Fredman P, Seed B
Cell. 1991;67(1):35-44 - PMID: 1717159

The T cell activation antigen CD27 is a member of the nerve growth factor/tumor necrosis factor receptor gene family.

Camerini D, Walz G, Loenen WA, Borst J, Seed B
J Immunol. 1991;147(9):3165-9 - PMID: 1655907

A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide.

Jüppner H, Abou-Samra AB, Freeman M, Kong XF, Schipani E, Richards J, Kolakowski LF, Hock J, Potts JT, Kronenberg HM
Science. 1991;254(5034):1024-6 - PMID: 1658941

Expression of type I and type II bovine scavenger receptors in Chinese hamster ovary cells: lipid droplet accumulation and nonreciprocal cross competition by acetylated and oxidized low density lipoprotein.

Freeman M, Ekkel Y, Rohrer L, Penman M, Freedman NJ, Chisolm GM, Krieger M
Proc Natl Acad Sci U S A. 1991;88(11):4931-5 - PMID: 2052575 - PMCID: PMC51781

Nuclear tRNA(Tyr) genes are highly amplified at a single chromosomal site in the genome of Arabidopsis thaliana.

Beier D, Stange N, Gross HJ, Beier H
Mol Gen Genet. 1991;225(1):72-80 - PMID: 2000093

Expression of nuclear tRNA(Tyr) genes from Arabidopsis thaliana in HeLa cell and wheat germ extracts.

Stange N, Beier D, Beier H
Plant Mol Biol. 1991;16(5):865-75 - PMID: 1859869

Regulation of transcription and cell identity by POU domain proteins.

Ruvkun G, Finney M
Cell. 1991;64(3):475-8 - PMID: 1991317

Nematode homeobox cluster.

Bürglin TR, Ruvkun G, Coulson A, Hawkins NC, McGhee JD, Schaller D, Wittmann C, Müller F, Waterston RH
Nature. 1991;351(6329):703 - PMID: 1676487

Negative regulatory sequences in the lin-14 3'-untranslated region are necessary to generate a temporal switch during Caenorhabditis elegans development.

Wightman B, Bürglin TR, Gatto J, Arasu P, Ruvkun G
Genes Dev. 1991;5(10):1813-24 - PMID: 1916264

Temporal regulation of lin-14 by the antagonistic action of two other heterochronic genes, lin-4 and lin-28.

Arasu P, Wightman B, Ruvkun G
Genes Dev. 1991;5(10):1825-33 - PMID: 1916265

Induction of Arabidopsis defense genes by virulent and avirulent Pseudomonas syringae strains and by a cloned avirulence gene.

Dong X, Mindrinos M, Davis KR, Ausubel FM
Plant Cell. 1991;3(1):61-72 - PMID: 1824335 - PMCID: PMC159979

Antibody-targeted photolysis: in vitro studies with Sn(IV) chlorin e6 covalently bound to monoclonal antibodies using a modified dextran carrier.

Rakestraw SL, Tompkins RG, Yarmush ML
Proc Natl Acad Sci U S A. 1990;87(11):4217-21 - PMID: 1693435 - PMCID: PMC54079

Injury-induced inhibition of small intestinal protein and nucleic acid synthesis.

Carter EA, Hatz RA, Yarmush ML, Tompkins RG
Gastroenterology. 1990;98(6):1445-51 - PMID: 1692545

Cutaneous thermal injury alters macromolecular permeability of rat small intestine.

Carter EA, Tompkins RG, Schiffrin E, Burke JF
Surgery. 1990;107(3):335-41 - PMID: 2309150

Imaging infections with antibodies. A quantitative autoradiographic analysis.

Morrel EM, Tompkins RG, Fischman AJ, Wilkinson RA, Yarmush ML
J Immunol Methods. 1990;130(1):39-48 - PMID: 2193059

A new approach to the cryopreservation of hepatocytes in a sandwich culture configuration.

Koebe HG, Dunn JC, Toner M, Sterling LM, Hubel A, Cravalho EG, Yarmush ML, Tompkins RG
Cryobiology. 1990;27(5):576-84 - PMID: 2249459

Circulating interleukin-1 and tumor necrosis factor in septic shock and experimental endotoxin fever.

Cannon JG, Tompkins RG, Gelfand JA, Michie HR, Stanford GG, van der Meer JW, Endres S, Lonnemann G, Corsetti J, Chernow B
J Infect Dis. 1990;161(1):79-84 - PMID: 2295861

Equilibrium binding characteristics of monoclonal antibodies recognizing melanoma cell surface antigens.

Shockley TR, Mandeville JT, Tompkins RG, Yarmush ML
Hybridoma. 1990;9(6):527-44 - PMID: 2076895

Prokaryotic signal transduction mediated by sensor and regulator protein pairs.

Albright LM, Huala E, Ausubel FM
Annu Rev Genet. 1990;23:311-36 - PMID: 2694934

Rhizobium meliloti nodD genes mediate host-specific activation of nodABC.

Honma MA, Asomaning M, Ausubel FM
J Bacteriol. 1990;172(2):901-11 - PMID: 2298703 - PMCID: PMC208518

Detection of heteroduplex DNA molecules among the products of Saccharomyces cerevisiae meiosis.

Lichten M, Goyon C, Schultes NP, Treco D, Szostak JW, Haber JE, Nicolas A
Proc Natl Acad Sci U S A. 1990;87(19):7653-7 - PMID: 2217196 - PMCID: PMC54806

Phylogenetic and genetic evidence for base-triples in the catalytic domain of group I introns.

Michel F, Ellington AD, Couture S, Szostak JW
Nature. 1990;347(6293):578-80 - PMID: 2215683

Decreasing gradients of gene conversion on both sides of the initiation site for meiotic recombination at the ARG4 locus in yeast.

Schultes NP, Szostak JW
Genetics. 1990;126(4):813-22 - PMID: 1981763 - PMCID: PMC1204280

Mutational analysis of conserved nucleotides in a self-splicing group I intron.

Couture S, Ellington AD, Gerber AS, Cherry JM, Doudna JA, Green R, Hanna M, Pace U, Rajagopal J, Szostak JW
J Mol Biol. 1990;215(3):345-58 - PMID: 1700131

In vitro selection of RNA molecules that bind specific ligands.

Ellington AD, Szostak JW
Nature. 1990;346(6287):818-22 - PMID: 1697402

In vitro genetic analysis of the Tetrahymena self-splicing intron.

Green R, Ellington AD, Szostak JW
Nature. 1990;347(6291):406-8 - PMID: 2215650

Chemical synthesis of oligoribonucleotides containing 2-aminopurine: substrates for the investigation of ribozyme function.

Doudna JA, Szostak JW, Rich A, Usman N
J Org Chem. 1990;55(21):5547-9 - PMID: 11540922

Saccharomyces cerevisiae homoserine kinase is homologous to prokaryotic homoserine kinases.

Schultes NP, Ellington AD, Cherry JM, Szostak JW
Gene. 1990;96(2):177-80 - PMID: 2176637

Point mutations in the yeast histone H4 gene prevent silencing of the silent mating type locus HML.

Park EC, Szostak JW
Mol Cell Biol. 1990;10(9):4932-4 - PMID: 2117703 - PMCID: PMC361112

Electrolyte gradient gels for DNA sequencing.

Sheen JY, Seed B
Biotechniques. 1990;6(10):942-4 - PMID: 3273397

A CD4 domain important for HIV-mediated syncytium formation lies outside the virus binding site.

Camerini D, Seed B
Cell. 1990;60(5):747-54 - PMID: 2107024

Improved genetic selection for screening bacteriophage libraries by homologous recombination in vivo.

Kurnit DM, Seed B
Proc Natl Acad Sci U S A. 1990;87(8):3166-9 - PMID: 2183225 - PMCID: PMC53855

The B-cell antigen CD22 mediates monocyte and erythrocyte adhesion.

Stamenkovic I, Seed B
Nature. 1990;345(6270):74-7 - PMID: 1691828

Expression and characterization of human CD4:immunoglobulin fusion proteins.

Zettlmeissl G, Gregersen JP, Duport JM, Mehdi S, Reiner G, Seed B
DNA Cell Biol. 1990;9(5):347-53 - PMID: 2196903

CD44 is the principal cell surface receptor for hyaluronate.

Aruffo A, Stamenkovic I, Melnick M, Underhill CB, Seed B
Cell. 1990;61(7):1303-13 - PMID: 1694723

Identification of the intracytoplasmic region essential for signal transduction through a B cell activation molecule, CD40.

Inui S, Kaisho T, Kikutani H, Stamenkovic I, Seed B, Clark EA, Kishimoto T
Eur J Immunol. 1990;20(8):1747-53 - PMID: 1698631

Expression of the CD6 T lymphocyte differentiation antigen in normal human brain.

Mayer B, Funke I, Seed B, Riethmüller G, Weiss E
J Neuroimmunol. 1990;29(1-3):193-202 - PMID: 2211985

The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen.

Classon BJ, Williams AF, Willis AC, Seed B, Stamenkovic I
J Exp Med. 1990;172(3):1007 - PMID: 2388030 - PMCID: PMC2188538

Recognition by ELAM-1 of the sialyl-Lex determinant on myeloid and tumor cells.

Walz G, Aruffo A, Kolanus W, Bevilacqua M, Seed B
Science. 1990;250(4984):1132-5 - PMID: 1701275

Thymosin beta 4 is expressed in ROS 17/2.8 osteosarcoma cells in a regulated manner.

Atkinson MJ, Freeman MW, Kronenberg HM
Mol Endocrinol. 1990;4(1):69-74 - PMID: 2325669

An ancient, highly conserved family of cysteine-rich protein domains revealed by cloning type I and type II murine macrophage scavenger receptors.

Freeman M, Ashkenas J, Rees DJ, Kingsley DM, Copeland NG, Jenkins NA, Krieger M
Proc Natl Acad Sci U S A. 1990;87(22):8810-4 - PMID: 1978939 - PMCID: PMC55049

Coiled-coil fibrous domains mediate ligand binding by macrophage scavenger receptor type II.

Rohrer L, Freeman M, Kodama T, Penman M, Krieger M
Nature. 1990;343(6258):570-2 - PMID: 2300208

Type I macrophage scavenger receptor contains alpha-helical and collagen-like coiled coils.

Kodama T, Freeman M, Rohrer L, Zabrecky J, Matsudaira P, Krieger M
Nature. 1990;343(6258):531-5 - PMID: 2300204

Detection of mutations and DNA polymorphisms using whole genome Southern Cross hybridization.

Ruvkun G, Gilbert W, Horvitz HR
Nucleic Acids Res. 1990;18(4):809-15 - PMID: 2315039 - PMCID: PMC330331

The unc-86 gene product couples cell lineage and cell identity in C. elegans.

Finney M, Ruvkun G
Cell. 1990;63(5):895-905 - PMID: 2257628

Genomic subtraction for cloning DNA corresponding to deletion mutations.

Straus D, Ausubel FM
Proc Natl Acad Sci U S A. 1990;87(5):1889-93 - PMID: 2408039 - PMCID: PMC53589

The structure, distribution and evolution of the Ta1 retrotransposable element family of Arabidopsis thaliana.

Voytas DF, Konieczny A, Cummings MP, Ausubel FM
Genetics. 1990;126(3):713-21 - PMID: 2174394 - PMCID: PMC1204225

Low-density lipoprotein transport in blood vessel walls of squirrel monkeys.

Tompkins RG, Yarmush ML, Schnitzer JJ, Colton CK, Smith KA, Stemerman MB
Am J Physiol. 1989;257(2 Pt 2):H452-64 - PMID: 2764130

Increased survival after massive thermal injuries in adults: preliminary report using artificial skin.

Tompkins RG, Hilton JF, Burke JF, Schoenfeld DA, Hegarty MT, Bondoc CC, Quinby WC, Behringer GE, Ackroyd FW
Crit Care Med. 1989;17(8):734-40 - PMID: 2546715

Inhibition of in vivo DNA synthesis in regenerating rat liver following thermal injury.

Carter EA, Kirkham SE, Tompkins RG, Burke JF
Biochem Biophys Res Commun. 1989;160(1):196-201 - PMID: 2785385

Hepatic and intestinal blood flow following thermal injury.

Carter EA, Tompkins RG, Burke JF
J Burn Care Rehabil. 1989;9(4):347-50 - PMID: 3220848

Hepatocyte function and extracellular matrix geometry: long-term culture in a sandwich configuration.

Dunn JC, Yarmush ML, Koebe HG, Tompkins RG
FASEB J. 1989;3(2):174-7 - PMID: 2914628

Autoradiographic method for quantitation of radiolabeled proteins in tissues using indium-111.

Morrell EM, Tompkins RG, Fischman AJ, Wilkinson RA, Burke JF, Rubin RH, Strauss HW, Yarmush ML
J Nucl Med. 1989;30(9):1538-45 - PMID: 2504892

Macromolecular transport within heart valves.

Tompkins RG, Schnitzer JJ, Yarmush ML
Circ Res. 1989;64(6):1213-23 - PMID: 2720921

Occult gastrointestinal bleeding: newer techniques and diagnosis and therapy.

Moncure AC, Tompkins RG, Athanasoulis CA, Welch CE
Adv Surg. 1989;22:141-77 - PMID: 2645744

A dual-labeling method for identifying differentially expressed genes: use in the identification of cDNA clones that hybridize to RNAs whose abundance in tomato flowers is potentially regulated by gibberellins.

Olszewski NE, Gast RT, Ausubel FM
Gene. 1989;77(1):155-62 - PMID: 2663653

Identification of a gene linked to Rhizobium meliloti ntrA whose product is homologous to a family to ATP-binding proteins.

Albright LM, Ronson CW, Nixon BT, Ausubel FM
J Bacteriol. 1989;171(4):1932-41 - PMID: 2703463 - PMCID: PMC209842

The central domain of Rhizobium meliloti NifA is sufficient to activate transcription from the R. meliloti nifH promoter.

Huala E, Ausubel FM
J Bacteriol. 1989;171(6):3354-65 - PMID: 2722751 - PMCID: PMC210058

General method for site-directed mutagenesis in Escherichia coli O18ac:K1:H7: deletion of the inducible superoxide dismutase gene, sodA, does not diminish bacteremia in neonatal rats.

Bloch CA, Thorne GM, Ausubel FM
Infect Immun. 1989;57(7):2141-8 - PMID: 2543632 - PMCID: PMC313853

Rhizobium meliloti 1021 has three differentially regulated loci involved in glutamine biosynthesis, none of which is essential for symbiotic nitrogen fixation.

de Bruijn FJ, Rossbach S, Schneider M, Ratet P, Messmer S, Szeto WW, Ausubel FM, Schell J
J Bacteriol. 1989;171(3):1673-82 - PMID: 2563998 - PMCID: PMC209797

The guanosine binding site of the Tetrahymena ribozyme.

Michel F, Hanna M, Green R, Bartel DP, Szostak JW
Nature. 1989;342(6248):391-5 - PMID: 2685606

Double-strand breaks at an initiation site for meiotic gene conversion.

Sun H, Treco D, Schultes NP, Szostak JW
Nature. 1989;338(6210):87-90 - PMID: 2645528

An initiation site for meiotic gene conversion in the yeast Saccharomyces cerevisiae.

Nicolas A, Treco D, Schultes NP, Szostak JW
Nature. 1989;338(6210):35-9 - PMID: 2537472

Telomerase: the beginning of the ends.

Szostak JW
Nature. 1989;337(6205):303-4 - PMID: 2765013

Miniribozymes, small derivatives of the sunY intron, are catalytically active.

Doudna JA, Szostak JW
Mol Cell Biol. 1989;9(12):5480-3 - PMID: 2685567 - PMCID: PMC363717

RNA structure, not sequence, determines the 5' splice-site specificity of a group I intron.

Doudna JA, Cormack BP, Szostak JW
Proc Natl Acad Sci U S A. 1989;86(19):7402-6 - PMID: 2678103 - PMCID: PMC298070

Stereochemical course of catalysis by the Tetrahymena ribozyme.

Rajagopal J, Doudna JA, Szostak JW
Science. 1989;244(4905):692-4 - PMID: 2470151

A mutant with a defect in telomere elongation leads to senescence in yeast.

Lundblad V, Szostak JW
Cell. 1989;57(4):633-43 - PMID: 2655926

RNA-catalysed synthesis of complementary-strand RNA.

Doudna JA, Szostak JW
Nature. 1989;339(6225):519-22 - PMID: 2660003

Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins.

Bevilacqua MP, Stengelin S, Gimbrone MA, Seed B
Science. 1989;243(4895):1160-5 - PMID: 2466335

A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas.

Stamenkovic I, Clark EA, Seed B
EMBO J. 1989;8(5):1403-10 - PMID: 2475341 - PMCID: PMC400967

A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family.

Stamenkovic I, Amiot M, Pesando JM, Seed B
Cell. 1989;56(6):1057-62 - PMID: 2466575

CD36 directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes.

Oquendo P, Hundt E, Lawler J, Seed B
Cell. 1989;58(1):95-101 - PMID: 2473841

Improved suppressor tRNA cloning vectors and plasmid-phage recombination.

Huang HV, Little PF, Seed B
Biotechnology. 1989;10:269-83 - PMID: 3061517

Isolation and expression of functional high-affinity Fc receptor complementary DNAs.

Allen JM, Seed B
Science. 1989;243(4889):378-81 - PMID: 2911749

The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen.

Classon BJ, Williams AF, Willis AC, Seed B, Stamenkovic I
J Exp Med. 1989;169(4):1497-502 - PMID: 2466944 - PMCID: PMC2189247

Monocyte antigen CD14 is a phospholipid anchored membrane protein.

Simmons DL, Tan S, Tenen DG, Nicholson-Weller A, Seed B
Blood. 1989;73(1):284-9 - PMID: 2462937

Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c demonstrates a hierarchy of exclusion in fibroblasts.

Aruffo A, Seed B
J Immunol. 1989;143(5):1723-30 - PMID: 2701945

A human macrophage-associated antigen (CD68) detected by six different monoclonal antibodies.

Micklem K, Rigney E, Cordell J, Simmons D, Stross P, Turley H, Seed B, Mason D
Br J Haematol. 1989;73(1):6-11 - PMID: 2803980

Leu-8/TQ1 is the human equivalent of the Mel-14 lymph node homing receptor.

Camerini D, James SP, Stamenkovic I, Seed B
Nature. 1989;342(6245):78-82 - PMID: 2509939

Risk factors in coronary artery disease and cardiac rehabilitation. In: Haber E, Eagle KA, Austen WG, eds

Freeman MW, Rigotti NA, and T. Force
The Practice of Cardiology. 1989;:563-614

Mutations in signal sequence cleavage domain of preproparathyroid hormone alter protein translocation, signal sequence cleavage, and membrane-binding properties.

Wiren KM, Ivashkiv L, Ma P, Freeman MW, Potts JT, Kronenberg HM
Mol Endocrinol. 1989;3(2):240-50 - PMID: 2710131

Molecular genetics of the Caenorhabditis elegans heterochronic gene lin-14.

Ruvkun G, Ambros V, Coulson A, Waterston R, Sulston J, Horvitz HR
Genetics. 1989;121(3):501-16 - PMID: 2565854 - PMCID: PMC1203636

The Caenorhabditis elegans heterochronic gene lin-14 encodes a nuclear protein that forms a temporal developmental switch.

Ruvkun G, Giusto J
Nature. 1989;338(6213):313-9 - PMID: 2922060

Caenorhabditis elegans has scores of homoeobox-containing genes.

Bürglin TR, Finney M, Coulson A, Ruvkun G
Nature. 1989;341(6239):239-43 - PMID: 2571091

Arabidopsis thaliana mutant that develops as a light-grown plant in the absence of light.

Chory J, Peto C, Feinbaum R, Pratt L, Ausubel F
Cell. 1989;58(5):991-9 - PMID: 2776216

Redistribution of blood flow after thermal injury and hemorrhagic shock.

Carter EA, Tompkins RG, Yarmush ML, Walker WA, Burke JF
J Appl Physiol. 1988;65(4):1782-8 - PMID: 3182540

Increase of sialyltransferase activity in the small intestine following thermal injury in rats.

Ch SW, Carter EA, Tompkins RG, Burke JF
Biochem Biophys Res Commun. 1988;153(1):377-81 - PMID: 3259879

Rectal necrosis after pelvic crush injury.

Tompkins RG, McCabe CJ, Burke JF, Keating MA, Wright CD
J Trauma. 1988;28(5):697-9 - PMID: 3367418

Significant reductions in mortality for children with burn injuries through the use of prompt eschar excision.

Tompkins RG, Remensnyder JP, Burke JF, Tompkins DM, Hilton JF, Schoenfeld DA, Behringer GE, Bondoc CC, Briggs SE, Quinby WC
Ann Surg. 1988;208(5):577-85 - PMID: 3190284 - PMCID: PMC1493782

Measurement of 125I-low density lipoprotein uptake in selected tissues of the squirrel monkey by quantitative autoradiography.

Tompkins RG, Schnitzer JJ, Yarmush ML, Colton CK, Smith KA
Am J Pathol. 1988;132(3):526-42 - PMID: 3414782 - PMCID: PMC1880767

Interference between Rhizobium meliloti and Rhizobium trifolii nodulation genes: genetic basis of R. meliloti dominance.

Debellé F, Maillet F, Vasse J, Rosenberg C, de Billy F, Truchet G, Dénarié J, Ausubel FM
J Bacteriol. 1988;170(12):5718-27 - PMID: 2848012 - PMCID: PMC211674

Specialized binary vector for plant transformation: expression of the Arabidopsis thaliana AHAS gene in Nicotiana tabacum.

Olszewski NE, Martin FB, Ausubel FM
Nucleic Acids Res. 1988;16(22):10765-82 - PMID: 3060849 - PMCID: PMC338938

Developmental regulation of nodule-specific genes in alfalfa root nodules.

Dunn K, Dickstein R, Feinbaum R, Burnett BK, Peterman TK, Thoidis G, Goodman HM, Ausubel FM
Mol Plant Microbe Interact. 1988;1(2):66-74 - PMID: 2908768

Expression of nodule-specific genes in alfalfa root nodules blocked at an early stage of development.

Dickstein R, Bisseling T, Reinhold VN, Ausubel FM
Genes Dev. 1988;2(6):677-87 - PMID: 3417147

Transcriptional regulation of the Arabidopsis thaliana chalcone synthase gene.

Feinbaum RL, Ausubel FM
Mol Cell Biol. 1988;8(5):1985-92 - PMID: 3386631 - PMCID: PMC363377

Genetic dissection of an RNA enzyme.

Doudna JA, Gerber AS, Cherry JM, Szostak JW
Cold Spring Harb Symp Quant Biol. 1988;52:173-80 - PMID: 2456876

Gene conversion adjacent to regions of double-strand break repair.

Orr-Weaver TL, Nicolas A, Szostak JW
Mol Cell Biol. 1988;8(12):5292-8 - PMID: 3072478 - PMCID: PMC365631

Telomeric repeat from T. thermophila cross hybridizes with human telomeres.

Allshire RC, Gosden JR, Cross SH, Cranston G, Rout D, Sugawara N, Szostak JW, Fantes PA, Hastie ND
Nature. 1988;332(6165):656-9 - PMID: 2833706

Characterization of two telomeric DNA processing reactions in Saccharomyces cerevisiae.

Murray AW, Claus TE, Szostak JW
Mol Cell Biol. 1988;8(11):4642-50 - PMID: 3062364 - PMCID: PMC365553

A simple phase-extraction assay for chloramphenicol acyltransferase activity.

Seed B, Sheen JY
Gene. 1988;67(2):271-7 - PMID: 3169576

Functional analysis of CD2, CD4, and CD8 in T-cell activation.

Bierer BE, Greenstein JL, Sleckman B, Ratnofsky S, Peterson A, Seed B, Burakoff SJ
Ann N Y Acad Sci. 1988;532:199-206 - PMID: 3052208

Analysis of two cDNA clones encoding the B lymphocyte antigen CD20 (B1, Bp35), a type III integral membrane protein.

Stamenkovic I, Seed B
J Exp Med. 1988;167(6):1975-80 - PMID: 3260267 - PMCID: PMC2189672

Expression of the T-cell surface molecule CD2 and an epitope-loss CD2 mutant to define the role of lymphocyte function-associated antigen 3 (LFA-3) in T-cell activation.

Bierer BE, Peterson A, Barbosa J, Seed B, Burakoff SJ
Proc Natl Acad Sci U S A. 1988;85(4):1194-8 - PMID: 2448792 - PMCID: PMC279733

Genetic analysis of monoclonal antibody and HIV binding sites on the human lymphocyte antigen CD4.

Peterson A, Seed B
Cell. 1988;54(1):65-72 - PMID: 2454749

The Fc gamma receptor of natural killer cells is a phospholipid-linked membrane protein.

Simmons D, Seed B
Nature. 1988;333(6173):568-70 - PMID: 2967436

Isolation of cDNAs of scrapie-modulated RNAs by subtractive hybridization of a cDNA library.

Duguid JR, Rohwer RG, Seed B
Proc Natl Acad Sci U S A. 1988;85(15):5738-42 - PMID: 2456582 - PMCID: PMC281836

CD19, the earliest differentiation antigen of the B cell lineage, bears three extracellular immunoglobulin-like domains and an Epstein-Barr virus-related cytoplasmic tail.

Stamenkovic I, Seed B
J Exp Med. 1988;168(3):1205-10 - PMID: 2459292 - PMCID: PMC2189043

Isolation of cDNAs for two distinct human Fc receptors by ligand affinity cloning.

Stengelin S, Stamenkovic I, Seed B
EMBO J. 1988;7(4):1053-9 - PMID: 3402431 - PMCID: PMC454434

Nucleotide sequence of three cDNAs for the human high affinity Fc receptor (FcRI).

Allen JM, Seed B
Nucleic Acids Res. 1988;16(24):11824 - PMID: 2974947 - PMCID: PMC339124

Isolation of a cDNA encoding CD33, a differentiation antigen of myeloid progenitor cells.

Simmons D, Seed B
J Immunol. 1988;141(8):2797-800 - PMID: 3139766

ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM.

Simmons D, Makgoba MW, Seed B
Nature. 1988;331(6157):624-7 - PMID: 3340213

Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor.

Yamasaki K, Taga T, Hirata Y, Yawata H, Kawanishi Y, Seed B, Taniguchi T, Hirano T, Kishimoto T
Science. 1988;241(4867):825-8 - PMID: 3136546

Central nervous system lesions in pediatric patients: Gd-DTPA-enhanced MR imaging.

Powers TA, Partain CL, Kessler RM, Freeman MW, Robertson RH, Wyatt SH, Whelan HT
Radiology. 1988;169(3):723-6 - PMID: 3055036

Wheat germ splicing endonuclease is highly specific for plant pre-tRNAs.

Stange N, Gross HJ, Beier H
EMBO J. 1988;7(12):3823-8 - PMID: 3208752 - PMCID: PMC454960

The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products.

Herr W, Sturm RA, Clerc RG, Corcoran LM, Baltimore D, Sharp PA, Ingraham HA, Rosenfeld MG, Finney M, Ruvkun G
Genes Dev. 1988;2(12A):1513-6 - PMID: 3215510

The C. elegans cell lineage and differentiation gene unc-86 encodes a protein with a homeodomain and extended similarity to transcription factors.

Finney M, Ruvkun G, Horvitz HR
Cell. 1988;55(5):757-69 - PMID: 2903797

Isolation of a higher eukaryotic telomere from Arabidopsis thaliana.

Richards EJ, Ausubel FM
Cell. 1988;53(1):127-36 - PMID: 3349525

A copia-like transposable element family in Arabidopsis thaliana.

Voytas DF, Ausubel FM
Nature. 1988;336(6196):242-4 - PMID: 2904123

Differential Expression in Bundle Sheath and Mesophyll Cells of Maize of Genes for Photosystem II Components Encoded by the Plastid Genome.

Sheen JY, Bogorad L
Plant Physiol. 1988;86(4):1020-6 - PMID: 16666025 - PMCID: PMC1054621

Enzymatic function of alginate immobilized rat hepatocytes.

Tompkins RG, Carter EA, Carlson JD, Yarmush ML
Biotechnol Bioeng. 1988;31(1):11-8 - PMID: 18581557

Regulation of levels of nuclear transcripts for C4 photosynthesis in bundle sheath and mesophyll cells of maize leaves.

Sheen JY, Bogorad L
Plant Mol Biol. 1987;8(3):227-38 - PMID: 24301127

Differential expression of oxygen-evolving polypeptide genes in maize leaf cell types.

Sheen JY, Sayre RT, Bogorad L
Plant Mol Biol. 1987;9(3):217-26 - PMID: 24276970

Rhizobium meliloti ntrA (rpoN) gene is required for diverse metabolic functions.

Ronson CW, Nixon BT, Albright LM, Ausubel FM
J Bacteriol. 1987;169(6):2424-31 - PMID: 3034856 - PMCID: PMC212082

Identification and characterization of the Rhizobium meliloti ntrC gene: R. meliloti has separate regulatory pathways for activation of nitrogen fixation genes in free-living and symbiotic cells.

Szeto WW, Nixon BT, Ronson CW, Ausubel FM
J Bacteriol. 1987;169(4):1423-32 - PMID: 2881918 - PMCID: PMC211963

Conservation of structure and location of Rhizobium meliloti and Klebsiella pneumoniae nifB genes.

Buikema WJ, Klingensmith JA, Gibbons SL, Ausubel FM
J Bacteriol. 1987;169(3):1120-6 - PMID: 3029020 - PMCID: PMC211909

Isolation and characterization of symbiotic mutants of bradyrhizobium sp. (Arachis) strain NC92: mutants with host-specific defects in nodulation and nitrogen fixation.

Wilson KJ, Anjaiah V, Nambiar PT, Ausubel FM
J Bacteriol. 1987;169(5):2177-86 - PMID: 3032910 - PMCID: PMC212124

Regulation of nitrogen fixation genes.

Gussin GN, Ronson CW, Ausubel FM
Annu Rev Genet. 1987;20:567-91 - PMID: 3545064

Genetic and structural analysis of the Rhizobium meliloti fixA, fixB, fixC, and fixX genes.

Earl CD, Ronson CW, Ausubel FM
J Bacteriol. 1987;169(3):1127-36 - PMID: 3029021 - PMCID: PMC211910

Deduced products of C4-dicarboxylate transport regulatory genes of Rhizobium leguminosarum are homologous to nitrogen regulatory gene products.

Ronson CW, Astwood PM, Nixon BT, Ausubel FM
Nucleic Acids Res. 1987;15(19):7921-34 - PMID: 3671068 - PMCID: PMC306317

Rhizobium meliloti has three functional copies of the nodD symbiotic regulatory gene.

Honma MA, Ausubel FM
Proc Natl Acad Sci U S A. 1987;84(23):8558-62 - PMID: 3479806 - PMCID: PMC299584

Conserved domains in bacterial regulatory proteins that respond to environmental stimuli.

Ronson CW, Nixon BT, Ausubel FM
Cell. 1987;49(5):579-81 - PMID: 3555840

The yeast ARD1 gene product is required for repression of cryptic mating-type information at the HML locus.

Whiteway M, Freedman R, Van Arsdell S, Szostak JW, Thorner J
Mol Cell Biol. 1987;7(10):3713-22 - PMID: 3316986 - PMCID: PMC368027

Identification of healed terminal DNA fragments in linear minichromosomes of Schizosaccharomyces pombe.

Matsumoto T, Fukui K, Niwa O, Sugawara N, Szostak JW, Yanagida M
Mol Cell Biol. 1987;7(12):4424-30 - PMID: 2830493 - PMCID: PMC368126

Structural conventions for group I introns.

Burke JM, Belfort M, Cech TR, Davies RW, Schweyen RJ, Shub DA, Szostak JW, Tabak HF
Nucleic Acids Res. 1987;15(18):7217-21 - PMID: 3658691 - PMCID: PMC306243

Roles of the 2 microns gene products in stable maintenance of the 2 microns plasmid of Saccharomyces cerevisiae.

Reynolds AE, Murray AW, Szostak JW
Mol Cell Biol. 1987;7(10):3566-73 - PMID: 3316982 - PMCID: PMC368010

Artificial chromosomes.

Murray AW, Szostak JW
Sci Am. 1987;257(5):62-8 - PMID: 3317814

Chromosome segregation in mitosis and meiosis.

Murray AW, Szostak JW
Annu Rev Cell Biol. 1987;1:289-315 - PMID: 3916318

Monoclonal antibody and ligand binding sites of the T cell erythrocyte receptor (CD2).

Peterson A, Seed B
Nature. 1987;329(6142):842-6 - PMID: 2444890

Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system.

Aruffo A, Seed B
Proc Natl Acad Sci U S A. 1987;84(23):8573-7 - PMID: 2825196 - PMCID: PMC299587

An LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2.

Seed B
Nature. 1987;329(6142):840-2 - PMID: 3313052

Expression and function of CD4 in a murine T-cell hybridoma.

Sleckman BP, Peterson A, Jones WK, Foran JA, Greenstein JL, Seed B, Burakoff SJ
Nature. 1987;328(6128):351-3 - PMID: 3037388

Syrinx 2A: an improved lambda phage vector designed for screening DNA libraries by recombination in vivo.

Lutz CT, Hollifield WC, Seed B, Davie JM, Huang HV
Proc Natl Acad Sci U S A. 1987;84(13):4379-83 - PMID: 2955406 - PMCID: PMC305092

Molecular cloning of two CD7 (T-cell leukemia antigen) cDNAs by a COS cell expression system.

Aruffo A, Seed B
EMBO J. 1987;6(11):3313-6 - PMID: 3501369 - PMCID: PMC553785

Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure.

Seed B, Aruffo A
Proc Natl Acad Sci U S A. 1987;84(10):3365-9 - PMID: 2437578 - PMCID: PMC304871

Preproparathyroid hormone: Use of mutants to study secretion. In: Cohn DV, Martin TJ, Meunier PJ, eds.

Kronenberg HM, Wiren KM, Freeman MW, JT Potts Jr
Calcium Regulation and Bone Metabolism: Basic and Clinical Aspects, Vol. 9. Amsterdam: Excerpta Medica. 1987;9:773-777

Preproparathyroid hormone: a model for analyzing the secretory pathway.

Wiren KM, Freeman MW, Potts JT Jr, HM Kronenberg
Ann NY Acad Sci. 1987;493:43-49

Chemistry, molecular biology, and mode of action of parathyroid hormone.

Potts, JT Jr, Nussbaum S, Wiren K, Freeman M, Igarashi T, Okazaki T, Zajac J, Abou-Samra AB, Bringhurst FR, Segre G, HM Kronenberg
Proceedings of the First International Conference on New Actions of Parathyroid Hormone. Kobe, Japan. 1987;:ePub

Preproparathyroid hormone. A model for analyzing the secretory pathway.

Wiren KM, Freeman MW, Potts JT, Kronenberg HM
Ann N Y Acad Sci. 1987;493:43-9 - PMID: 3473968

Consequences of amino-terminal deletions of preproparathyroid hormone signal sequence.

Freeman MW, Wiren KM, Rapoport A, Lazar M, Potts JT, Kronenberg HM
Mol Endocrinol. 1987;1(9):628-38 - PMID: 3153480

A human and a plant intron-containing tRNATyr gene are both transcribed in a HeLa cell extract but spliced along different pathways.

van Tol H, Stange N, Gross HJ, Beier H
EMBO J. 1987;6(1):35-41 - PMID: 3502708 - PMCID: PMC553353

A nuclear Nicotiana DNA sequence homologous to the 5' half of tRNATyr may have derived from reverse transcription of a pre-tRNA splicing intermediate.

Stange N, Gross HJ, Beier H
Nucleic Acids Res. 1987;15(13):5477 - PMID: 3648681 - PMCID: PMC305973

A cell-free plant extract for accurate pre-tRNA processing, splicing and modification.

Stange N, Beier H
EMBO J. 1987;6(9):2811-8 - PMID: 3678205 - PMCID: PMC553707

Gibberellin-Induced Changes in the Populations of Translatable mRNAs and Accumulated Polypeptides in Dwarfs of Maize and Pea.

Chory J, Voytas DF, Olszewski NE, Ausubel FM
Plant Physiol. 1987;83(1):15-23 - PMID: 16665192 - PMCID: PMC1056291

Rhizobium symbiotic genes required for nodulation of legume and nonlegume hosts.

Marvel DJ, Torrey JG, Ausubel FM
Proc Natl Acad Sci U S A. 1987;84(5):1319-23 - PMID: 16593814 - PMCID: PMC304419

Burn therapy 1985: acute management.

Tompkins RG, Burke JF
Intensive Care Med. 1986;12(4):289-95 - PMID: 3531277

Prompt eschar excision: a treatment system contributing to reduced burn mortality. A statistical evaluation of burn care at the Massachusetts General Hospital (1974-1984).

Tompkins RG, Burke JF, Schoenfeld DA, Bondoc CC, Quinby WC, Behringer GC, Ackroyd FW
Ann Surg. 1986;204(3):272-81 - PMID: 3753058 - PMCID: PMC1251276

Biological nitrogen fixation: recent advances and future prospects.

Ausubel FM
Regul Toxicol Pharmacol. 1986;6(1):1-10 - PMID: 3704206

Symbiotic nitrogen fixation: developmental genetics of nodule formation.

Lang-Unnasch N, Dunn K, Ausubel FM
Cold Spring Harb Symp Quant Biol. 1986;50:555-63 - PMID: 3868494

Paraquat-mediated selection for mutations in the manganese-superoxide dismutase gene sodA.

Bloch CA, Ausubel FM
J Bacteriol. 1986;168(2):795-8 - PMID: 3023287 - PMCID: PMC213554

Construction and behavior of circularly permuted and telocentric chromosomes in Saccharomyces cerevisiae.

Murray AW, Szostak JW
Mol Cell Biol. 1986;6(9):3166-72 - PMID: 3537731 - PMCID: PMC367052

An alternative pathway for meiotic chromosome segregation in yeast.

Dawson DS, Murray AW, Szostak JW