Publications for All Faculty

RNA signatures allow rapid identification of pathogens and antibiotic susceptibilities.

Barczak AK, Gomez JE, Kaufmann BB, Hinson ER, Cosimi L, Borowsky ML, Onderdonk AB, Stanley SA, Kaur D, Bryant KF, Knipe DM, Sloutsky A, Hung DT
Proc Natl Acad Sci U S A. 2012;109(16):6217-22 - PMID: 22474362 - PMCID: PMC3341018 - DOI: 10.1073/pnas.1119540109

Patterns of Care at End of Life in Children With Advanced Heart Disease.

Morell E, Wolfe J, Scheurer M, Thiagarajan R, Morin C, Beke DM, Smoot L, Cheng H, Gauvreau K, Blume ED
Arch Pediatr Adolesc Med. 2012;166(8):745-8 - PMID: 22473887 - PMCID: PMC4119813

Benchmarking Outcomes in the Critically Injured Trauma Patient and the Effect of Implementing Standard Operating Procedures.

Cuschieri J, Johnson JL, Sperry J, West MA, Moore EE, Minei JP, Bankey PE, Nathens AB, Cuenca AG, Efron PA, Hennessy L, Xiao W, Mindrinos MN, McDonald-Smith GP, Mason PH, Billiar TR, Schoenfeld DA, Warren HS, Cobb JP, Moldawer LL, Davis RW, Maier RV, Tompkins RG,
Ann Surg. 2012;255(5):993-9 - PMID: 22470077 - PMCID: PMC3327791 - DOI: 10.1097/SLA.0b013e31824f1ebc

Glucose metabolism during the early after burn injury.

Xu H, Yu YM, Ma H, Carter EA, Fagan S, Tompkins RG, Fischman AJ
J Surg Res. 2012;179(1):e83-90 - PMID: 22459295 - PMCID: PMC4074901 - DOI: 10.1016/j.jss.2012.02.037

Autophagy and the immune system.

Kuballa P, Nolte WM, Castoreno AB, Xavier RJ
Annu Rev Immunol. 2012;30:611-46 - PMID: 22449030 - DOI: 10.1146/annurev-immunol-020711-074948

In Vivo Molecular Imaging of Murine Embryonic Stem Cells Delivered to a Burn Wound Surface via Integra® Scaffolding.

Hamrahi VF, Goverman J, Jung W, Wu JC, Fischman AJ, Tompkins RG, Yu YY, Fagan SP, Carter EA
J Burn Care Res. 2012;33(2):e49-54 - PMID: 22441149 - PMCID: PMC3311992

Apoptotic cells can deliver chemotherapeutics to engulfing macrophages and suppress inflammatory cytokine production.

Perez B, Paquette N, Païdassi H, Zhai B, White K, Skvirsky R, Lacy-Hulbert A, Stuart LM
J Biol Chem. 2012;287(19):16029-36 - PMID: 22433861 - PMCID: PMC3346138 - DOI: 10.1074/jbc.M112.340489

In Vitro Selection of Highly Modified Cyclic Peptides That Act as Tight Binding Inhibitors.

Guillen Schlippe YV, Hartman MC, Josephson K, Szostak JW
J Am Chem Soc. 2012;134(25):10469-77 - PMID: 22428867 - PMCID: PMC3384292 - DOI: 10.1021/ja301017y

Integration of architectural and cytologic driven image algorithms for prostate adenocarcinoma identification.

Hipp J, Monaco J, Kunju LP, Cheng J, Yagi Y, Rodriguez-Canales J, Emmert-Buck MR, Hewitt S, Feldman MD, Tomaszewski JE, Toner M, Tompkins RG, Flotte T, Lucas D, Gilbertson JR, Madabhushi A, Balis U
Anal Cell Pathol (Amst). 2012;35(4):251-65 - PMID: 22425661 - PMCID: PMC4605585 - DOI: 10.3233/ACP-2012-0054

Repression of Germline RNAi Pathways in Somatic Cells by Retinoblastoma Pathway Chromatin Complexes.

Wu X, Shi Z, Cui M, Han M, Ruvkun G
PLoS Genet. 2012;8(3):e1002542 - PMID: 22412383 - PMCID: PMC3297578 - DOI: 10.1371/journal.pgen.1002542

The mevalonate pathway regulates microRNA activity in Caenorhabditis elegans.

Shi Z, Ruvkun G
Proc Natl Acad Sci U S A. 2012;109(12):4568-73 - PMID: 22396595 - PMCID: PMC3311396 - DOI: 10.1073/pnas.1202421109

ONCOGENIC KRAS REGULATES BMP4 EXPRESSION IN COLON CANCER CELL LINES.

Duerr EM, Mizukami Y, Moriichi K, Gala M, Jo WS, Kikuchi H, Xavier RJ, Chung DC
Am J Physiol Gastrointest Liver Physiol. 2012;302(10):G1223-30 - PMID: 22383492 - PMCID: PMC3362092 - DOI: 10.1152/ajpgi.00047.2011

Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects.

Ramirez CL, Certo MT, Mussolino C, Goodwin MJ, Cradick TJ, McCaffrey AP, Cathomen T, Scharenberg AM, Joung JK
Nucleic Acids Res. 2012;40(12):5560-8 - PMID: 22373919 - PMCID: PMC3384306 - DOI: 10.1093/nar/gks179

A Peroxidase-Dependent Apoplastic Oxidative Burst in Cultured Arabidopsis Cells Functions in MAMP-Elicited Defense.

O'Brien JA, Daudi A, Finch P, Butt VS, Whitelegge JP, Souda P, Ausubel FM, Bolwell GP
Plant Physiol. 2012;158(4):2013-27 - PMID: 22319074 - PMCID: PMC3320203 - DOI: 10.1104/pp.111.190140

Genomic epidemiology of the Escherichia coli O104:H4 outbreaks in Europe, 2011.

Grad YH, Lipsitch M, Feldgarden M, Arachchi HM, Cerqueira GC, Fitzgerald M, Godfrey P, Haas BJ, Murphy CI, Russ C, Sykes S, Walker BJ, Wortman JR, Young S, Zeng Q, Abouelleil A, Bochicchio J, Chauvin S, Desmet T, Gujja S, McCowan C, Montmayeur A, Steelman S, Frimodt-Møller J, Petersen AM, Struve C, Krogfelt KA, Bingen E, Weill FX, Lander ES, Nusbaum C, Birren BW, Hung DT, Hanage WP
Proc Natl Acad Sci U S A. 2012;109(8):3065-70 - PMID: 22315421 - PMCID: PMC3286951 - DOI: 10.1073/pnas.1121491109

Genome-wide siRNA screen for mediators of NF-?B activation.

Gewurz BE, Towfic F, Mar JC, Shinners NP, Takasaki K, Zhao B, Cahir-McFarland ED, Quackenbush J, Xavier RJ, Kieff E
Proc Natl Acad Sci U S A. 2012;109(7):2467-72 - PMID: 22308454 - PMCID: PMC3289371 - DOI: 10.1073/pnas.1120542109

Survival of children with burn injuries.

Tompkins RG
Lancet. 2012;379(9820):983-4 - PMID: 22296811 - PMCID: PMC4019221 - DOI: 10.1016/S0140-6736(11)61626-7

Activated ribonucleotides undergo a sugar pucker switch upon binding to a single-stranded RNA template.

Zhang N, Zhang S, Szostak JW
J Am Chem Soc. 2012;134(8):3691-4 - PMID: 22296305 - PMCID: PMC3448298 - DOI: 10.1021/ja212027q

Thermal Injury Activates eEF2k-Dependent eEF2 Pathway in Pediatric Patients.

Song J, Finnerty CC, Herndon DN, Kraft R, Boehning D, Brooks NC, Tompkins RG, Jeschke MG
JPEN J Parenter Enteral Nutr. 2012;36(5):596-602 - PMID: 22269896 - PMCID: PMC3580832 - DOI: 10.1177/0148607111422234

HIV-1 Nef mobilizes lipid rafts in macrophages through a pathway that competes with ABCA1-dependent cholesterol efflux.

Cui HL, Grant A, Mukhamedova N, Pushkarsky T, Jennelle L, Dubrovsky L, Gaus K, Fitzgerald ML, Sviridov D, Bukrinsky M
J Lipid Res. 2012;53(4):696-708 - PMID: 22262807 - PMCID: PMC3307646 - DOI: 10.1194/jlr.M023119

The apoplastic oxidative burst peroxidase in Arabidopsis is a major component of pattern-triggered immunity.

Daudi A, Cheng Z, O'Brien JA, Mammarella N, Khan S, Ausubel FM, Bolwell GP
Plant Cell. 2012;24(1):275-87 - PMID: 22247251 - PMCID: PMC3289579 - DOI: 10.1105/tpc.111.093039

Severe injury is associated with insulin resistance, endoplasmic reticulum stress response, and unfolded protein response.

Jeschke MG, Finnerty CC, Herndon DN, Song J, Boehning D, Tompkins RG, Baker HV, Gauglitz GG
Ann Surg. 2012;255(2):370-8 - PMID: 22241293 - PMCID: PMC3395076 - DOI: 10.1097/SLA.0b013e31823e76e7

Immune defense mechanisms in the Caenorhabditis elegans intestinal epithelium.

Pukkila-Worley R, Ausubel FM
Curr Opin Immunol. 2012;24(1):3-9 - PMID: 22236697 - PMCID: PMC3660727 - DOI: 10.1016/j.coi.2011.10.004

The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques.

van Gils JM, Derby MC, Fernandes LR, Ramkhelawon B, Ray TD, Rayner KJ, Parathath S, Distel E, Feig JL, Alvarez-Leite JI, Rayner AJ, McDonald TO, O'Brien KD, Stuart LM, Fisher EA, Lacy-Hulbert A, Moore KJ
Nat Immunol. 2012;13(2):136-43 - PMID: 22231519 - PMCID: PMC3262880 - DOI: 10.1038/ni.2205

STAT6 phosphorylation inhibitors block eotaxin-3 secretion in bronchial epithelial cells.

Zhou L, Kawate T, Liu X, Kim YB, Zhao Y, Feng G, Banerji J, Nash H, Whitehurst C, Jindal S, Siddiqui A, Seed B, Wolfe JL
Bioorg Med Chem. 2011;20(2):750-8 - PMID: 22217933 - DOI: 10.1016/j.bmc.2011.12.006

Incidence of Catheter-Associated Bloodstream Infection After Introduction of Minocycline and Rifampin Antimicrobial-Coated Catheters in a Pediatric Burn Population.

Weber JM, Sheridan RL, Fagan S, Ryan CM, Pasternack MS, Tompkins RG
J Burn Care Res. 2012;33(4):539-43 - PMID: 22210071 - DOI: 10.1097/BCR.0b013e31823c4cd5

Attempts to define life do not help to understand the origin of life.

Szostak JW
J Biomol Struct Dyn. 2012;29(4):599-600 - PMID: 22208251 - PMCID: PMC4208307 - DOI: 10.1080/073911012010524998

SILAM for quantitative proteomics of liver Akt1/PKB? after burn injury.

Lu XM, Tompkins RG, Fischman AJ
Int J Mol Med. 2011;29(3):461-71 - PMID: 22179310 - PMCID: PMC3981641 - DOI: 10.3892/ijmm.2011.861

Resuscitation-promoting factors are required for ?-lactam tolerance and the permeability barrier in Mycobacterium tuberculosis.

Wivagg CN, Hung DT
Antimicrob Agents Chemother. 2011;56(3):1591-4 - PMID: 22155826 - PMCID: PMC3294900 - DOI: 10.1128/AAC.06027-11

Bacterial effectors: learning on the fly.

Boyer L, Paquette N, Silverman N, Stuart LM
Adv Exp Med Biol. 2011;710:29-36 - PMID: 22127883 - PMCID: PMC3427734 - DOI: 10.1007/978-1-4419-5638-5_4

The C. elegans DAF-2 Insulin-Like Receptor is Abundantly Expressed in the Nervous System and Regulated by Nutritional Status.

Kimura KD, Riddle DL, Ruvkun G
Cold Spring Harb Symp Quant Biol. 2011;76:113-20 - PMID: 22123849 - DOI: 10.1101/sqb.2011.76.010660

The Creating an Optimal Warfarin Nomogram (CROWN) Study.

Perlstein TS, Goldhaber SZ, Nelson K, Joshi V, Morgan TV, Lesko LJ, Lee JY, Gobburu J, Schoenfeld D, Kucherlapati R, Freeman MW, Creager MA
Thromb Haemost. 2011;107(1):59-68 - PMID: 22116191 - PMCID: PMC4133142 - DOI: 10.1160/TH11-08-0568

A genomic storm in critically injured humans.

Xiao W, Mindrinos MN, Seok J, Cuschieri J, Cuenca AG, Gao H, Hayden DL, Hennessy L, Moore EE, Minei JP, Bankey PE, Johnson JL, Sperry J, Nathens AB, Billiar TR, West MA, Brownstein BH, Mason PH, Baker HV, Finnerty CC, Jeschke MG, López MC, Klein MB, Gamelli RL, Gibran NS, Arnoldo B, Xu W, Zhang Y, Calvano SE, McDonald-Smith GP, Schoenfeld DA, Storey JD, Cobb JP, Warren HS, Moldawer LL, Herndon DN, Lowry SF, Maier RV, Davis RW, Tompkins RG,
J Exp Med. 2011;208(13):2581-90 - PMID: 22110166 - PMCID: PMC3244029 - DOI: 10.1084/jem.20111354

The ERI-6/7 helicase acts at the first stage of an siRNA amplification pathway that targets recent gene duplications.

Fischer SE, Montgomery TA, Zhang C, Fahlgren N, Breen PC, Hwang A, Sullivan CM, Carrington JC, Ruvkun G
PLoS Genet. 2011;7(11):e1002369 - PMID: 22102828 - PMCID: PMC3213143 - DOI: 10.1371/journal.pgen.1002369

Local injection of bevacizumab (Avastin) and angiolytic KTP laser treatment of recurrent respiratory papillomatosis of the vocal folds: a prospective study.

Zeitels SM, Barbu AM, Landau-Zemer T, Lopez-Guerra G, Burns JA, Friedman AD, Freeman MW, Halvorsen YD, Hillman RE
Ann Otol Rhinol Laryngol. 2011;120(10):627-34 - PMID: 22097147 - DOI: 10.1177/000348941112001001

PrimerBank: a PCR primer database for quantitative gene expression analysis, 2012 update.

Wang X, Spandidos A, Wang H, Seed B
Nucleic Acids Res. 2011;40(Database issue):D1144-9 - PMID: 22086960 - PMCID: PMC3245149 - DOI: 10.1093/nar/gkr1013

CARMA1 is necessary for optimal T cell responses in a murine model of allergic asthma.

Ramadas RA, Roche MI, Moon JJ, Ludwig T, Xavier RJ, Medoff BD
J Immunol. 2011;187(12):6197-207 - PMID: 22075698 - PMCID: PMC3237896 - DOI: 10.4049/jimmunol.1101348

Down-regulation of glutatione S-transferase ? 4 (hGSTA4) in the muscle of thermally injured patients is indicative of susceptibility to bacterial infection.

Apidianakis Y, Que YA, Xu W, Tegos GP, Zimniak P, Hamblin MR, Tompkins RG, Xiao W, Rahme LG
FASEB J. 2011;26(2):730-7 - PMID: 22038048 - PMCID: PMC3290433 - DOI: 10.1096/fj.11-192484

UV-C-irradiated Arabidopsis and tobacco emit volatiles that trigger genomic instability in neighboring plants.

Yao Y, Danna CH, Zemp FJ, Titov V, Ciftci ON, Przybylski R, Ausubel FM, Kovalchuk I
Plant Cell. 2011;23(10):3842-52 - PMID: 22028460 - PMCID: PMC3229153 - DOI: 10.1105/tpc.111.089003

Image-based genome-wide siRNA screen identifies selective autophagy factors.

Orvedahl A, Sumpter R, Xiao G, Ng A, Zou Z, Tang Y, Narimatsu M, Gilpin C, Sun Q, Roth M, Forst CV, Wrana JL, Zhang YE, Luby-Phelps K, Xavier RJ, Xie Y, Levine B
Nature. 2011;480(7375):113-7 - PMID: 22020285 - PMCID: PMC3229641 - DOI: 10.1038/nature10546

The changing pattern and implications of multiple organ failure after blunt injury with hemorrhagic shock*

Minei JP, Cuschieri J, Sperry J, Moore EE, West MA, Harbrecht BG, O'Keefe GE, Cohen MJ, Moldawer LL, Tompkins RG, Maier RV
Crit Care Med. 2012;40(4):1129-1135 - PMID: 22020243 - PMCID: PMC3343366 - DOI: 10.1097/CCM.0b013e3182376e9f

Pathogen-derived effectors trigger protective immunity via activation of the Rac2 enzyme and the IMD or Rip kinase signaling pathway.

Boyer L, Magoc L, Dejardin S, Cappillino M, Paquette N, Hinault C, Charriere GM, Ip WK, Fracchia S, Hennessy E, Erturk-Hasdemir D, Reichhart JM, Silverman N, Lacy-Hulbert A, Stuart LM
Immunity. 2011;35(4):536-49 - PMID: 22018470 - PMCID: PMC3258503 - DOI: 10.1016/j.immuni.2011.08.015

Genome-wide expression profiling implicates a MAST3-regulated gene set in colonic mucosal inflammation of ulcerative colitis patients.

Labbé C, Boucher G, Foisy S, Alikashani A, Nkwimi H, David G, Beaudoin M, Goyette P, Charron G, Xavier RJ, Rioux JD
Inflamm Bowel Dis. 2011;18(6):1072-80 - PMID: 21994190 - PMCID: PMC3269563 - DOI: 10.1002/ibd.21887

Regulation of the C. elegans molt by pqn-47.

Russel S, Frand AR, Ruvkun G
Dev Biol. 2011;360(2):297-309 - PMID: 21989027 - PMCID: PMC3618673 - DOI: 10.1016/j.ydbio.2011.09.025

Pseudomonas aeruginosa RhlR is required to neutralize the cellular immune response in a Drosophila melanogaster oral infection model.

Limmer S, Haller S, Drenkard E, Lee J, Yu S, Kocks C, Ausubel FM, Ferrandon D
Proc Natl Acad Sci U S A. 2011;108(42):17378-83 - PMID: 21987808 - PMCID: PMC3198323 - DOI: 10.1073/pnas.1114907108

automated DNA sequencing technology.

Slatko BE, Kieleczawa J, Ju J, Gardner AF, Hendrickson CL, Ausubel FM
Curr Protoc Mol Biol. 2011;Chapter 7:Unit7.2 - PMID: 21987057 - DOI: 10.1002/0471142727.mb0702s96

Engineering designer nucleases with customized cleavage specificities.

Sander JD, Maeder ML, Joung JK
Curr Protoc Mol Biol. 2011;Chapter 12:Unit12.13 - PMID: 21987054 - PMCID: PMC3379964 - DOI: 10.1002/0471142727.mb1213s96

Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease.

Rivas MA, Beaudoin M, Gardet A, Stevens C, Sharma Y, Zhang CK, Boucher G, Ripke S, Ellinghaus D, Burtt N, Fennell T, Kirby A, Latiano A, Goyette P, Green T, Halfvarson J, Haritunians T, Korn JM, Kuruvilla F, Lagacé C, Neale B, Lo KS, Schumm P, Törkvist L, , , , Dubinsky MC, Brant SR, Silverberg MS, Duerr RH, Altshuler D, Gabriel S, Lettre G, Franke A, D'Amato M, McGovern DP, Cho JH, Rioux JD, Xavier RJ, Daly MJ
Nat Genet. 2011;43(11):1066-73 - PMID: 21983784 - PMCID: PMC3378381 - DOI: 10.1038/ng.952

The Caenorhabditis elegans SOMI-1 zinc finger protein and SWI/SNF promote regulation of development by the mir-84 microRNA.

Hayes GD, Riedel CG, Ruvkun G
Genes Dev. 2011;25(19):2079-92 - PMID: 21979920 - PMCID: PMC3197206 - DOI: 10.1101/gad.17153811

The two-component sensor kinase KinB acts as a non-canonical switch between acute and chronic infection.

Chand NS, Hung DT
Virulence. 2011;2(6):553-8 - PMID: 21971182 - DOI: 10.4161/viru.2.6.17987

HCV causes chronic endoplasmic reticulum stress leading to adaptation and interference with the unfolded protein response.

Merquiol E, Uzi D, Mueller T, Goldenberg D, Nahmias Y, Xavier RJ, Tirosh B, Shibolet O
PLoS One. 2011;6(9):e24660 - PMID: 21949742 - PMCID: PMC3176279 - DOI: 10.1371/journal.pone.0024660

Novel mitochondria-targeted antioxidant peptide ameliorates burn-induced apoptosis and endoplasmic reticulum stress in the skeletal muscle of mice.

Lee HY, Kaneki M, Andreas J, Tompkins RG, Martyn JA
Shock. 2011;36(6):580-5 - PMID: 21937949 - PMCID: PMC3230221 - DOI: 10.1097/SHK.0b013e3182366872

Dissecting inflammatory complications in critically injured patients by within-patient gene expression changes: a longitudinal clinical genomics study.

Desai KH, Tan CS, Leek JT, Maier RV, Tompkins RG, Storey JD,
PLoS Med. 2011;8(9):e1001093 - PMID: 21931541 - PMCID: PMC3172280 - DOI: 10.1371/journal.pmed.1001093

Microfluidics-based capture of human neutrophils for expression analysis in blood and bronchoalveolar lavage.

Warner EA, Kotz KT, Ungaro RF, Abouhamze AS, Lopez MC, Cuenca AG, Kelly-Scumpia KM, Moreno C, O'Malley KA, Lanz JD, Baker HV, Martin LC, Toner M, Tompkins RG, Efron PA, Moldawer LL
Lab Invest. 2011;91(12):1787-95 - PMID: 21931299 - PMCID: PMC3957199 - DOI: 10.1038/labinvest.2011.94

An optimal degree of physical and chemical heterogeneity for the origin of life?

Szostak JW
Philos Trans R Soc Lond B Biol Sci. 2011;366(1580):2894-901 - PMID: 21930580 - PMCID: PMC3158921 - DOI: 10.1098/rstb.2011.0140

Engineering zinc finger nucleases for targeted mutagenesis of zebrafish.

Sander JD, Yeh JR, Peterson RT, Joung JK
Methods Cell Biol. 2011;104:51-8 - PMID: 21924156 - DOI: 10.1016/B978-0-12-374814-0.00003-3

Phosphoprotein associated with glycosphingolipid-enriched microdomains differentially modulates SRC kinase activity in brain maturation.

Lindquist S, Karitkina D, Langnaese K, Posevitz-Fejfar A, Schraven B, Xavier R, Seed B, Lindquist JA
PLoS One. 2011;6(9):e23978 - PMID: 21915273 - PMCID: PMC3167820 - DOI: 10.1371/journal.pone.0023978

Association of heat production with 18F-FDG accumulation in murine brown adipose tissue after stress.

Carter EA, Bonab AA, Paul K, Yerxa J, Tompkins RG, Fischman AJ
J Nucl Med. 2011;52(10):1616-20 - PMID: 21914754 - PMCID: PMC4082963 - DOI: 10.2967/jnumed.111.090175

In situ genetic correction of the sickle cell anemia mutation in human induced pluripotent stem cells using engineered zinc finger nucleases.

Sebastiano V, Maeder ML, Angstman JF, Haddad B, Khayter C, Yeo DT, Goodwin MJ, Hawkins JS, Ramirez CL, Batista LF, Artandi SE, Wernig M, Joung JK
Stem Cells. 2011;29(11):1717-26 - PMID: 21898685 - PMCID: PMC3285772 - DOI: 10.1002/stem.718

Farnesyltransferase inhibitor FTI-277 reduces mortality of septic mice along with improved bacterial clearance.

Yang W, Yamada M, Tamura Y, Chang K, Mao J, Zou L, Feng Y, Kida K, Scherrer-Crosbie M, Chao W, Ichinose F, Yu YM, Fischman AJ, Tompkins RG, Yao S, Kaneki M
J Pharmacol Exp Ther. 2011;339(3):832-41 - PMID: 21873557 - PMCID: PMC3226365 - DOI: 10.1124/jpet.111.183558

Wild type and Tangier disease ABCA1 mutants modulate cellular amyloid-? production independent of cholesterol efflux activity.

Kim WS, Hill AF, Fitzgerald ML, Freeman MW, Evin G, Garner B
J Alzheimers Dis. 2011;27(2):441-52 - PMID: 21860089 - DOI: 10.3233/JAD-2011-110521

Acetylcholine ?7 nicotinic and dopamine D(2) receptors are targeted to many of the same postsynaptic dendrites and astrocytes in the rodent prefrontal cortex.

Duffy AM, Fitzgerald ML, Chan J, Robinson DC, Milner TA, Mackie K, Pickel VM
Synapse. 2011;65(12):1350-67 - PMID: 21858872 - PMCID: PMC3356922 - DOI: 10.1002/syn.20977

Use of an optical trap for study of host-pathogen interactions for dynamic live cell imaging.

Tam JM, Castro CE, Heath RJ, Mansour MK, Cardenas ML, Xavier RJ, Lang MJ, Vyas JM
J Vis Exp. 2011;(53):ePub - PMID: 21841755 - PMCID: PMC3197446 - DOI: 10.3791/3123

Evolution of functional nucleic acids in the presence of nonheritable backbone heterogeneity.

Trevino SG, Zhang N, Elenko MP, Lupták A, Szostak JW
Proc Natl Acad Sci U S A. 2011;108(33):13492-7 - PMID: 21825162 - PMCID: PMC3158193 - DOI: 10.1073/pnas.1107113108

Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection.

Pattanayak V, Ramirez CL, Joung JK, Liu DR
Nat Methods. 2011;8(9):765-70 - PMID: 21822273 - PMCID: PMC3164905 - DOI: 10.1038/nmeth.1670

Targeted gene disruption in somatic zebrafish cells using engineered TALENs.

Sander JD, Cade L, Khayter C, Reyon D, Peterson RT, Joung JK, Yeh JR
Nat Biotechnol. 2011;29(8):697-8 - PMID: 21822241 - PMCID: PMC3154023 - DOI: 10.1038/nbt.1934

Induction of stable drug resistance in human breast cancer cells using a combinatorial zinc finger transcription factor library.

Lee J, Hirsh AS, Wittner BS, Maeder ML, Singavarapu R, Lang M, Janarthanan S, McDermott U, Yajnik V, Ramaswamy S, Joung JK, Sgroi DC
PLoS One. 2011;6(7):e21112 - PMID: 21818254 - PMCID: PMC3139592 - DOI: 10.1371/journal.pone.0021112

Patterns of medication administration from 2001 to 2009 in the treatment of children with acute burn injuries: a multicenter study.

Stoddard FJ, White GW, Kazis LE, Murphy JM, Sorrentino EA, Hinson M, Kim Stubbs T, Chan G, Sheridan RL, Palmieri T, Kagan R, Herndon D, Tompkins RG
J Burn Care Res. 2011;32(5):519-28 - PMID: 21811176 - DOI: 10.1097/BCR.0b013e31822bef92

Evaluation of the antioxidant peptide SS31 for treatment of burn-induced insulin resistance.

Carter EA, Bonab AA, Goverman J, Paul K, Yerxa J, Tompkins RG, Fischman AJ
Int J Mol Med. 2011;28(4):589-94 - PMID: 21805045 - PMCID: PMC4090514 - DOI: 10.3892/ijmm.2011.752

GRP78(BiP) facilitates the cytosolic delivery of anthrax lethal factor (LF) in vivo and functions as an unfoldase in vitro.

Tamayo AG, Slater L, Taylor-Parker J, Bharti A, Harrison R, Hung DT, Murphy JR
Mol Microbiol. 2011;81(5):1390-401 - PMID: 21797942 - PMCID: PMC4041151 - DOI: 10.1111/j.1365-2958.2011.07770.x

Recruitment of prefrontal cortical endocannabinoid signaling by glucocorticoids contributes to termination of the stress response.

Hill MN, McLaughlin RJ, Pan B, Fitzgerald ML, Roberts CJ, Lee TT, Karatsoreos IN, Mackie K, Viau V, Pickel VM, McEwen BS, Liu QS, Gorzalka BB, Hillard CJ
J Neurosci. 2011;31(29):10506-15 - PMID: 21775596 - PMCID: PMC3179266 - DOI: 10.1523/JNEUROSCI.0496-11.2011

Computer aided diagnostic tools aim to empower rather than replace pathologists: Lessons learned from computational chess.

Hipp J, Flotte T, Monaco J, Cheng J, Madabhushi A, Yagi Y, Rodriguez-Canales J, Emmert-Buck M, Dugan MC, Hewitt S, Toner M, Tompkins RG, Lucas D, Gilbertson JR, Balis UJ
J Pathol Inform. 2011;2:25 - PMID: 21773056 - PMCID: PMC3132993 - DOI: 10.4103/2153-3539.82050

Considerations for preparedness for a pediatric burn disaster.

Ryan CM, Antoon A, Fagan SP, Goverman J, Lawlor D, Sheridan RL, Tompkins RG
J Burn Care Res. 2011;32(5):e165-6 - PMID: 21772149 - DOI: 10.1097/BCR.0b013e31822ac9a4

HMG-CoA reductase inhibitors enhance phagocytosis by upregulating ATP-binding cassette transporter A7.

Tanaka N, Abe-Dohmae S, Iwamoto N, Fitzgerald ML, Yokoyama S
Atherosclerosis. 2011;217(2):407-14 - PMID: 21762915 - PMCID: PMC3150192 - DOI: 10.1016/j.atherosclerosis.2011.06.031

Preferential expression of integrin avb8 promotes generation of regulatory T cells by mouse CD103+ dendritic cells.

Païdassi H, Acharya M, Zhang A, Mukhopadhyay S, Kwon M, Chow C, Stuart LM, Savill J, Lacy-Hulbert A
Gastroenterology. 2011;141(5):1813-20 - PMID: 21745448 - PMCID: PMC3202651 - DOI: 10.1053/j.gastro.2011.06.076

Candida albicans infection of Caenorhabditis elegans induces antifungal immune defenses.

Pukkila-Worley R, Ausubel FM, Mylonakis E
PLoS Pathog. 2011;7(6):e1002074 - PMID: 21731485 - PMCID: PMC3121877 - DOI: 10.1371/journal.ppat.1002074

Genetics and pathogenesis of inflammatory bowel disease.

Khor B, Gardet A, Xavier RJ
Nature. 2011;474(7351):307-17 - PMID: 21677747 - PMCID: PMC3204665 - DOI: 10.1038/nature10209

A Francisella tularensis locus required for spermine responsiveness is necessary for virulence.

Russo BC, Horzempa J, O'Dee DM, Schmitt DM, Brown MJ, Carlson PE, Xavier RJ, Nau GJ
Infect Immun. 2011;79(9):3665-76 - PMID: 21670171 - PMCID: PMC3165480 - DOI: 10.1128/IAI.00135-11

MyD88-dependent TLR1/2 signals educate dendritic cells with gut-specific imprinting properties.

Wang S, Villablanca EJ, De Calisto J, Gomes DC, Nguyen DD, Mizoguchi E, Kagan JC, Reinecker HC, Hacohen N, Nagler C, Xavier RJ, Rossi-Bergmann B, Chen YB, Blomhoff R, Snapper SB, Mora JR
J Immunol. 2011;187(1):141-50 - PMID: 21646294 - PMCID: PMC3119749 - DOI: 10.4049/jimmunol.1003740

Zinc-finger nucleases for somatic gene therapy: the next frontier.

Rahman SH, Maeder ML, Joung JK, Cathomen T
Hum Gene Ther. 2011;22(8):925-33 - PMID: 21631241 - PMCID: PMC3159524 - DOI: 10.1089/hum.2011.087

Leucine-rich repeat (LRR) proteins: integrators of pattern recognition and signaling in immunity.

Ng A, Xavier RJ
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Recurrent chromosomal copy number alterations in sporadic chordomas.

Le LP, Nielsen GP, Rosenberg AE, Thomas D, Batten JM, Deshpande V, Schwab J, Duan Z, Xavier RJ, Hornicek FJ, Iafrate AJ
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The Arabidopsis flagellin receptor FLS2 mediates the perception of Xanthomonas Ax21 secreted peptides.

Danna CH, Millet YA, Koller T, Han SW, Bent AF, Ronald PC, Ausubel FM
Proc Natl Acad Sci U S A. 2011;108(22):9286-91 - PMID: 21576467 - PMCID: PMC3107323 - DOI: 10.1073/pnas.1106366108

Effects of burn injury, cold stress and cutaneous wound injury on the morphology and energy metabolism of murine brown adipose tissue (BAT) in vivo.

Carter EA, Bonab AA, Hamrahi V, Pitman J, Winter D, Macintosh LJ, Cyr EM, Paul K, Yerxa J, Jung W, Tompkins RG, Fischman AJ
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Artificial lantipeptides from in vitro translations.

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The sensor kinase KinB regulates virulence in acute Pseudomonas aeruginosa infection.

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J Bacteriol. 2011;193(12):2989-99 - PMID: 21515773 - PMCID: PMC3133189 - DOI: 10.1128/JB.01546-10

Bacterial and host determinants of MAL activation upon EPEC infection: the roles of Tir, ABRA, and FLRT3.

Heath RJ, Leong JM, Visegrády B, Machesky LM, Xavier RJ
PLoS Pathog. 2011;7(4):e1001332 - PMID: 21490959 - PMCID: PMC3072376 - DOI: 10.1371/journal.ppat.1001332

Targeted mutagenesis of duplicated genes in soybean with zinc-finger nucleases.

Curtin SJ, Zhang F, Sander JD, Haun WJ, Starker C, Baltes NJ, Reyon D, Dahlborg EJ, Goodwin MJ, Coffman AP, Dobbs D, Joung JK, Voytas DF, Stupar RM
Plant Physiol. 2011;156(2):466-73 - PMID: 21464476 - PMCID: PMC3177250 - DOI: 10.1104/pp.111.172981

Decreased parvalbumin immunoreactivity in the cortex and striatum of mice lacking the CB1 receptor.

Fitzgerald ML, Lupica CR, Pickel VM
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The path from bench to bedside: considerations before starting the journey.

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J Investig Med. 2011;59(5):746-51 - PMID: 21441830 - PMCID: PMC4255460 - DOI: 10.2310/JIM.0b013e3182160d70

Physical effects underlying the transition from primitive to modern cell membranes.

Budin I, Szostak JW
Proc Natl Acad Sci U S A. 2011;108(13):5249-54 - PMID: 21402937 - PMCID: PMC3069173 - DOI: 10.1073/pnas.1100498108

Spatially Invariant Vector Quantization: A pattern matching algorithm for multiple classes of image subject matter including pathology.

Hipp JD, Cheng JY, Toner M, Tompkins RG, Balis UJ
J Pathol Inform. 2011;2:13 - PMID: 21383936 - PMCID: PMC3049270 - DOI: 10.4103/2153-3539.77175

RESOLVING CLUSTERED WORMS VIA PROBABILISTIC SHAPE MODELS.

Wählby C, Riklin-Raviv T, Ljosa V, Conery AL, Golland P, Ausubel FM, Carpenter AE
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Optimal codon choice can improve the efficiency and fidelity of N-methyl amino acid incorporation into peptides by in-vitro translation.

Subtelny AO, Hartman MC, Szostak JW
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Microfluidics for T- lymphocyte cell separation and inflammation monitoring in burn patients.

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Human transcriptome array for high-throughput clinical studies.

Xu W, Seok J, Mindrinos MN, Schweitzer AC, Jiang H, Wilhelmy J, Clark TA, Kapur K, Xing Y, Faham M, Storey JD, Moldawer LL, Maier RV, Tompkins RG, Wong WH, Davis RW, Xiao W,
Proc Natl Acad Sci U S A. 2011;108(9):3707-12 - PMID: 21317363 - PMCID: PMC3048146 - DOI: 10.1073/pnas.1019753108

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

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Effects of glucagon-like peptide 1 on glycemia control and its metabolic consequence after severe thermal injury--studies in an animal model.

Shen CA, Fagan S, Fischman AJ, Carter EE, Chai JK, Lu XM, Yu YM, Tompkins RG
Surgery. 2011;149(5):635-44 - PMID: 21295809 - PMCID: PMC3079016 - DOI: 10.1016/j.surg.2010.11.017

A high throughput amenable Arabidopsis-P. aeruginosa system reveals a rewired regulatory module and the utility to identify potent anti-infectives.

Gopalan S, Ausubel FM
PLoS One. 2011;6(1):e16381 - PMID: 21283656 - PMCID: PMC3025032 - DOI: 10.1371/journal.pone.0016381

ZFNGenome: a comprehensive resource for locating zinc finger nuclease target sites in model organisms.

Reyon D, Kirkpatrick JR, Sander JD, Zhang F, Voytas DF, Joung JK, Dobbs D, Coffman CR
BMC Genomics. 2011;12:83 - PMID: 21276248 - PMCID: PMC3042413 - DOI: 10.1186/1471-2164-12-83

Probing bacterial pathogenesis with genetics, genomics, and chemical biology: past, present, and future approaches.

Gomez JE, Clatworthy A, Hung DT
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Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology.

Rossin EJ, Lage K, Raychaudhuri S, Xavier RJ, Tatar D, Benita Y, , Cotsapas C, Daly MJ
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mut-16 and other mutator class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans.

Zhang C, Montgomery TA, Gabel HW, Fischer SE, Phillips CM, Fahlgren N, Sullivan CM, Carrington JC, Ruvkun G
Proc Natl Acad Sci U S A. 2011;108(4):1201-8 - PMID: 21245313 - PMCID: PMC3029761 - DOI: 10.1073/pnas.1018695108

RNAi screening for fat regulatory genes with SRS microscopy.

Wang MC, Min W, Freudiger CW, Ruvkun G, Xie XS
Nat Methods. 2011;8(2):135-8 - PMID: 21240281 - PMCID: PMC3061290 - DOI: 10.1038/nmeth.1556

Control and manipulation of pathogens with an optical trap for live cell imaging of intercellular interactions.

Tam JM, Castro CE, Heath RJ, Cardenas ML, Xavier RJ, Lang MJ, Vyas JM
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Cancer. Germ cell genes and cancer.

Wu X, Ruvkun G
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Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA).

Sander JD, Dahlborg EJ, Goodwin MJ, Cade L, Zhang F, Cifuentes D, Curtin SJ, Blackburn JS, Thibodeau-Beganny S, Qi Y, Pierick CJ, Hoffman E, Maeder ML, Khayter C, Reyon D, Dobbs D, Langenau DM, Stupar RM, Giraldez AJ, Voytas DF, Peterson RT, Yeh JR, Joung JK
Nat Methods. 2010;8(1):67-9 - PMID: 21151135 - PMCID: PMC3018472 - DOI: 10.1038/nmeth.1542

Simvastatin treatment improves survival in a murine model of burn sepsis: Role of interleukin 6.

Beffa DC, Fischman AJ, Fagan SP, Hamrahi VF, Paul KW, Kaneki M, Yu YM, Tompkins RG, Carter EA
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Early enteral nutrition in burns: compliance with guidelines and associated outcomes in a multicenter study.

Mosier MJ, Pham TN, Klein MB, Gibran NS, Arnoldo BD, Gamelli RL, Tompkins RG, Herndon DN
J Burn Care Res. 2011;32(1):104-9 - PMID: 21116188 - PMCID: PMC3850279 - DOI: 10.1097/BCR.0b013e318204b3be

Failure and exploitation of autophagy in human pathologies-cellular integrity between inflammation, infection, and cell survival.

Kuballa P, Xavier RJ
Semin Immunopathol. 2010;32(4):319-22 - PMID: 21107575 - DOI: 10.1007/s00281-010-0229-5

The contribution of muscle to whole-body protein turnover throughout the course of burn injury in children.

Prelack K, Yu YM, Dylewski M, Lydon M, Sheridan RL, Tompkins RG
J Burn Care Res. 2010;31(6):942-8 - PMID: 21105320 - PMCID: PMC4084779 - DOI: 10.1097/BCR.0b013e3181f938e1

av Integrin expression by DCs is required for Th17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice.

Acharya M, Mukhopadhyay S, Païdassi H, Jamil T, Chow C, Kissler S, Stuart LM, Hynes RO, Lacy-Hulbert A
J Clin Invest. 2010;120(12):4445-52 - PMID: 21099114 - PMCID: PMC2993596 - DOI: 10.1172/JCI43796

Mining the plant-herbivore interface with a leafmining Drosophila of Arabidopsis.

Whiteman NK, Groen SC, Chevasco D, Bear A, Beckwith N, Gregory TR, Denoux C, Mammarella N, Ausubel FM, Pierce NE
Mol Ecol. 2010;20(5):995-1014 - PMID: 21073583 - PMCID: PMC3062943 - DOI: 10.1111/j.1365-294X.2010.04901.x

Predicting success of oligomerized pool engineering (OPEN) for zinc finger target site sequences.

Sander JD, Reyon D, Maeder ML, Foley JE, Thibodeau-Beganny S, Li X, Regan MR, Dahlborg EJ, Goodwin MJ, Fu F, Voytas DF, Joung JK, Dobbs D
BMC Bioinformatics. 2010;11:543 - PMID: 21044337 - PMCID: PMC3098093 - DOI: 10.1186/1471-2105-11-543

Chemoselective multicomponent one-pot assembly of purine precursors in water.

Powner MW, Sutherland JD, Szostak JW
J Am Chem Soc. 2010;132(46):16677-88 - PMID: 21043502 - PMCID: PMC2984373 - DOI: 10.1021/ja108197s

Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection.

Riley BE, Kaiser SE, Shaler TA, Ng AC, Hara T, Hipp MS, Lage K, Xavier RJ, Ryu KY, Taguchi K, Yamamoto M, Tanaka K, Mizushima N, Komatsu M, Kopito RR
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LRRK2 is involved in the IFN-gamma response and host response to pathogens.

Gardet A, Benita Y, Li C, Sands BE, Ballester I, Stevens C, Korzenik JR, Rioux JD, Daly MJ, Xavier RJ, Podolsky DK
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Morphology-guided graph search for untangling objects: C. elegans analysis.

Raviv TR, Ljosa V, Conery AL, Ausubel FM, Carpenter AE, Golland P, Wählby C
Med Image Comput Comput Assist Interv. 2010;13(Pt 3):634-41 - PMID: 20879454 - PMCID: PMC3050593

NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis.

Hirota SA, Ng J, Lueng A, Khajah M, Parhar K, Li Y, Lam V, Potentier MS, Ng K, Bawa M, McCafferty DM, Rioux KP, Ghosh S, Xavier RJ, Colgan SP, Tschopp J, Muruve D, MacDonald JA, Beck PL
Inflamm Bowel Dis. 2010;17(6):1359-72 - PMID: 20872834 - PMCID: PMC3026862 - DOI: 10.1002/ibd.21478

Stem cells and burns: review and therapeutic implications.

Butler KL, Goverman J, Ma H, Fischman A, Yu YM, Bilodeau M, Rad AM, Bonab AA, Tompkins RG, Fagan SP
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DNA ends: just the beginning (Nobel lecture).

Szostak JW
Angew Chem Int Ed Engl. 2010;49(41):7386-404 - PMID: 20818632 - DOI: 10.1002/anie.201000635

Single-molecule binding experiments on long time scales.

Elenko MP, Szostak JW, van Oijen AM
Rev Sci Instrum. 2010;81(8):083705 - PMID: 20815611 - DOI: 10.1063/1.3473936

Clinical microfluidics for neutrophil genomics and proteomics.

Kotz KT, Xiao W, Miller-Graziano C, Qian WJ, Russom A, Warner EA, Moldawer LL, De A, Bankey PE, Petritis BO, Camp DG, Rosenbach AE, Goverman J, Fagan SP, Brownstein BH, Irimia D, Xu W, Wilhelmy J, Mindrinos MN, Smith RD, Davis RW, Tompkins RG, Toner M,
Nat Med. 2010;16(9):1042-7 - PMID: 20802500 - PMCID: PMC3136804 - DOI: 10.1038/nm.2205

Human IRGM gene "to be or not to be".

Bekpen C, Xavier RJ, Eichler EE
Semin Immunopathol. 2010;32(4):437-44 - PMID: 20737271 - DOI: 10.1007/s00281-010-0224-x

Mutation of the ATP cassette binding transporter A1 (ABCA1) C-terminus disrupts HIV-1 Nef binding but does not block the Nef enhancement of ABCA1 protein degradation.

Mujawar Z, Tamehiro N, Grant A, Sviridov D, Bukrinsky M, Fitzgerald ML
Biochemistry. 2010;49(38):8338-49 - PMID: 20731376 - PMCID: PMC2943568 - DOI: 10.1021/bi100466q

Crohn disease: a current perspective on genetics, autophagy and immunity.

Stappenbeck TS, Rioux JD, Mizoguchi A, Saitoh T, Huett A, Darfeuille-Michaud A, Wileman T, Mizushima N, Carding S, Akira S, Parkes M, Xavier RJ
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Autonomous zinc-finger nuclease pairs for targeted chromosomal deletion.

Söllü C, Pars K, Cornu TI, Thibodeau-Beganny S, Maeder ML, Joung JK, Heilbronn R, Cathomen T
Nucleic Acids Res. 2010;38(22):8269-76 - PMID: 20716517 - PMCID: PMC3001086 - DOI: 10.1093/nar/gkq720

Plasma proteome response to severe burn injury revealed by 18O-labeled "universal" reference-based quantitative proteomics.

Qian WJ, Petritis BO, Kaushal A, Finnerty CC, Jeschke MG, Monroe ME, Moore RJ, Schepmoes AA, Xiao W, Moldawer LL, Davis RW, Tompkins RG, Herndon DN, Camp DG, Smith RD,
J Proteome Res. 2010;9(9):4779-89 - PMID: 20698492 - PMCID: PMC2945297 - DOI: 10.1021/pr1005026

Burn injury reduces neutrophil directional migration speed in microfluidic devices.

Butler KL, Ambravaneswaran V, Agrawal N, Bilodeau M, Toner M, Tompkins RG, Fagan S, Irimia D
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Engineering single Cys2His2 zinc finger domains using a bacterial cell-based two-hybrid selection system.

Thibodeau-Beganny S, Maeder ML, Joung JK
Methods Mol Biol. 2010;649:31-50 - PMID: 20680826 - DOI: 10.1007/978-1-60761-753-2_2

Effect of simvastatin on burn-induced alterations in tissue specific glucose metabolism: implications for burn associated insulin resistance.

Bonab AA, Carter EA, Paul K, Kaneki M, Yu YM, Tompkins RG, Fischman AJ
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Reactive bone marrow stromal cells attenuate systemic inflammation via sTNFR1.

Yagi H, Soto-Gutierrez A, Navarro-Alvarez N, Nahmias Y, Goldwasser Y, Kitagawa Y, Tilles AW, Tompkins RG, Parekkadan B, Yarmush ML
Mol Ther. 2010;18(10):1857-64 - PMID: 20664529 - PMCID: PMC2951565 - DOI: 10.1038/mt.2010.155

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease.

Lipinski MM, Zheng B, Lu T, Yan Z, Py BF, Ng A, Xavier RJ, Li C, Yankner BA, Scherzer CR, Yuan J
Proc Natl Acad Sci U S A. 2010;107(32):14164-9 - PMID: 20660724 - PMCID: PMC2922576 - DOI: 10.1073/pnas.1009485107

Wnt signaling regulates mitochondrial physiology and insulin sensitivity.

Yoon JC, Ng A, Kim BH, Bianco A, Xavier RJ, Elledge SJ
Genes Dev. 2010;24(14):1507-18 - PMID: 20634317 - PMCID: PMC2904941 - DOI: 10.1101/gad.1924910

A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions.

Lipinski MM, Hoffman G, Ng A, Zhou W, Py BF, Hsu E, Liu X, Eisenberg J, Liu J, Blenis J, Xavier RJ, Yuan J
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Circulating Nef induces dyslipidemia in simian immunodeficiency virus-infected macaques by suppressing cholesterol efflux.

Asztalos BF, Mujawar Z, Morrow MP, Grant A, Pushkarsky T, Wanke C, Shannon R, Geyer M, Kirchhoff F, Sviridov D, Fitzgerald ML, Bukrinsky M, Mansfield KG
J Infect Dis. 2010;202(4):614-23 - PMID: 20617930 - PMCID: PMC2932757 - DOI: 10.1086/654817

Distinct pathogenesis and host responses during infection of C. elegans by P. aeruginosa and S. aureus.

Irazoqui JE, Troemel ER, Feinbaum RL, Luhachack LG, Cezairliyan BO, Ausubel FM
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Human leucine-rich repeat proteins: a genome-wide bioinformatic categorization and functional analysis in innate immunity.

Ng AC, Eisenberg JM, Heath RJ, Huett A, Robinson CM, Nau GJ, Xavier RJ
Proc Natl Acad Sci U S A. 2010;108 Suppl 1:4631-8 - PMID: 20616063 - PMCID: PMC3063585 - DOI: 10.1073/pnas.1000093107

The transcription factor MafB antagonizes antiviral responses by blocking recruitment of coactivators to the transcription factor IRF3.

Kim H, Seed B
Nat Immunol. 2010;11(8):743-50 - PMID: 20581830 - PMCID: PMC3050627 - DOI: 10.1038/ni.1897

Bone marrow mesenchymal stromal cells attenuate organ injury induced by LPS and burn.

Yagi H, Soto-Gutierrez A, Kitagawa Y, Tilles AW, Tompkins RG, Yarmush ML
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A systems biology viewpoint on autophagy in health and disease.

Huett A, Goel G, Xavier RJ
Curr Opin Gastroenterol. 2010;26(4):302-9 - PMID: 20571384 - DOI: 10.1097/MOG.0b013e32833ae2ed

Mice lacking Dok-1, Dok-2, and Dok-3 succumb to aggressive histiocytic sarcoma.

Mashima R, Honda K, Yang Y, Morita Y, Inoue A, Arimura S, Nishina H, Ema H, Nakauchi H, Seed B, Oda H, Yamanashi Y
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Mesenchymal stem cells: Mechanisms of immunomodulation and homing.

Yagi H, Soto-Gutierrez A, Parekkadan B, Kitagawa Y, Tompkins RG, Kobayashi N, Yarmush ML
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Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes.

Westerberg LS, Meelu P, Baptista M, Eston MA, Adamovich DA, Cotta-de-Almeida V, Seed B, Rosen MK, Vandenberghe P, Thrasher AJ, Klein C, Alt FW, Snapper SB
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High frequency targeted mutagenesis in Arabidopsis thaliana using zinc finger nucleases.

Zhang F, Maeder ML, Unger-Wallace E, Hoshaw JP, Reyon D, Christian M, Li X, Pierick CJ, Dobbs D, Peterson T, Joung JK, Voytas DF
Proc Natl Acad Sci U S A. 2010;107(26):12028-33 - PMID: 20508152 - PMCID: PMC2900673 - DOI: 10.1073/pnas.0914991107

Berberine-INF55 (5-nitro-2-phenylindole) hybrid antimicrobials: effects of varying the relative orientation of the berberine and INF55 components.

Tomkiewicz D, Casadei G, Larkins-Ford J, Moy TI, Garner J, Bremner JB, Ausubel FM, Lewis K, Kelso MJ
Antimicrob Agents Chemother. 2010;54(8):3219-24 - PMID: 20498327 - PMCID: PMC2916310 - DOI: 10.1128/AAC.01715-09

Helical apolipoproteins of high-density lipoprotein enhance phagocytosis by stabilizing ATP-binding cassette transporter A7.

Tanaka N, Abe-Dohmae S, Iwamoto N, Fitzgerald ML, Yokoyama S
J Lipid Res. 2010;51(9):2591-9 - PMID: 20495215 - PMCID: PMC2918442 - DOI: 10.1194/jlr.M006049

The origins of cellular life.

Schrum JP, Zhu TF, Szostak JW
Cold Spring Harb Perspect Biol. 2010;2(9):a002212 - PMID: 20484387 - PMCID: PMC2926753 - DOI: 10.1101/cshperspect.a002212

Phagocytosis and phagosome acidification are required for pathogen processing and MyD88-dependent responses to Staphylococcus aureus.

Ip WK, Sokolovska A, Charriere GM, Boyer L, Dejardin S, Cappillino MP, Yantosca LM, Takahashi K, Moore KJ, Lacy-Hulbert A, Stuart LM
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MiR-33 contributes to the regulation of cholesterol homeostasis.

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Characterization and analysis of human chordoma cell lines.

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ZiFiT (Zinc Finger Targeter): an updated zinc finger engineering tool.

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Isolation and characterization of circulating tumor cells from patients with localized and metastatic prostate cancer.

Stott SL, Lee RJ, Nagrath S, Yu M, Miyamoto DT, Ulkus L, Inserra EJ, Ulman M, Springer S, Nakamura Z, Moore AL, Tsukrov DI, Kempner ME, Dahl DM, Wu CL, Iafrate AJ, Smith MR, Tompkins RG, Sequist LV, Toner M, Haber DA, Maheswaran S
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99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: Caenorhabditis elegans as a model to study tissues involved in host immunity and microbial pathogenesis.

Irazoqui JE, Ausubel FM
Clin Exp Immunol. 2010;160(1):48-57 - PMID: 20415851 - PMCID: PMC2841835 - DOI: 10.1111/j.1365-2249.2010.04122.x

Gene enrichment profiles reveal T-cell development, differentiation, and lineage-specific transcription factors including ZBTB25 as a novel NF-AT repressor.

Benita Y, Cao Z, Giallourakis C, Li C, Gardet A, Xavier RJ
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Identification of Drosophila Yin and PEPT2 as evolutionarily conserved phagosome-associated muramyl dipeptide transporters.

Charrière GM, Ip WE, Dejardin S, Boyer L, Sokolovska A, Cappillino MP, Cherayil BJ, Podolsky DK, Kobayashi KS, Silverman N, Lacy-Hulbert A, Stuart LM
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Host-encoded reporters for the detection and purification of multiple enveloped viruses.

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Toward a systems-level analysis of infection biology: a new method for conducting genetic screens in human cells.

Stanley SA, Hung DT
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Effect of stalling after mismatches on the error catastrophe in nonenzymatic nucleic acid replication.

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Innate immune responses activated in Arabidopsis roots by microbe-associated molecular patterns.

Millet YA, Danna CH, Clay NK, Songnuan W, Simon MD, Werck-Reichhart D, Ausubel FM
Plant Cell. 2010;22(3):973-90 - PMID: 20348432 - PMCID: PMC2861455 - DOI: 10.1105/tpc.109.069658

Binding of PDZ-RhoGEF to ATP-binding cassette transporter A1 (ABCA1) induces cholesterol efflux through RhoA activation and prevention of transporter degradation.

Okuhira K, Fitzgerald ML, Tamehiro N, Ohoka N, Suzuki K, Sawada J, Naito M, Nishimaki-Mogami T
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MLT-10 defines a family of DUF644 and proline-rich repeat proteins involved in the molting cycle of Caenorhabditis elegans.

Meli VS, Osuna B, Ruvkun G, Frand AR
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Exploring the interplay of barrier function and leukocyte recruitment in intestinal inflammation by targeting fucosyltransferase VII and trefoil factor 3.

Beck PL, Ihara E, Hirota SA, MacDonald JA, Meng D, Nanthakumar NN, Podolsky DK, Xavier RJ
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Genome-wide association identifies multiple ulcerative colitis susceptibility loci.

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Expanding roles for diverse physical phenomena during the origin of life.

Budin I, Szostak JW
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The fast track to multidrug resistance.

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ABC transporters, atherosclerosis and inflammation.

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bZIP transcription factor zip-2 mediates an early response to Pseudomonas aeruginosa infection in Caenorhabditis elegans.

Estes KA, Dunbar TL, Powell JR, Ausubel FM, Troemel ER
Proc Natl Acad Sci U S A. 2010;107(5):2153-8 - PMID: 20133860 - PMCID: PMC2836710 - DOI: 10.1073/pnas.0914643107

Targeting multiple biofilm pathways.

Hett EC, Hung DT
Chem Biol. 2009;16(12):1216-8 - PMID: 20064430 - DOI: 10.1016/j.chembiol.2009.12.003

The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus.

Brass AL, Huang IC, Benita Y, John SP, Krishnan MN, Feeley EM, Ryan BJ, Weyer JL, van der Weyden L, Fikrig E, Adams DJ, Xavier RJ, Farzan M, Elledge SJ
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Early acute kidney injury predicts progressive renal dysfunction and higher mortality in severely burned adults.

Mosier MJ, Pham TN, Klein MB, Gibran NS, Arnoldo BD, Gamelli RL, Tompkins RG, Herndon DN
J Burn Care Res. 2010;31(1):83-92 - PMID: 20061841 - PMCID: PMC3045668 - DOI: 10.1097/BCR.0b013e3181cb8c87

Fluorosomes: a convenient new reagent to detect and block multivalent and complex receptor-ligand interactions.

Kueng HJ, Manta C, Haiderer D, Leb VM, Schmetterer KG, Neunkirchner A, Byrne RA, Scheinecker C, Steinberger P, Seed B, Pickl WF
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CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.

Stewart CR, Stuart LM, Wilkinson K, van Gils JM, Deng J, Halle A, Rayner KJ, Boyer L, Zhong R, Frazier WA, Lacy-Hulbert A, El Khoury J, Golenbock DT, Moore KJ
Nat Immunol. 2009;11(2):155-61 - PMID: 20037584 - PMCID: PMC2809046 - DOI: 10.1038/ni.1836

Evolution of host innate defence: insights from Caenorhabditis elegans and primitive invertebrates.

Irazoqui JE, Urbach JM, Ausubel FM
Nat Rev Immunol. 2010;10(1):47-58 - PMID: 20029447 - PMCID: PMC2965059 - DOI: 10.1038/nri2689

Genome-wide transcriptome analysis of 150 cell samples.

Irimia D, Mindrinos M, Russom A, Xiao W, Wilhelmy J, Wang S, Heath JD, Kurn N, Tompkins RG, Davis RW, Toner M
Integr Biol (Camb). 2008;1(1):99-107 - PMID: 20023796 - PMCID: PMC3763906 - DOI: 10.1039/b814329c

RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans.

Sebastiani P, Montano M, Puca A, Solovieff N, Kojima T, Wang MC, Melista E, Meltzer M, Fischer SE, Andersen S, Hartley SH, Sedgewick A, Arai Y, Bergman A, Barzilai N, Terry DF, Riva A, Anselmi CV, Malovini A, Kitamoto A, Sawabe M, Arai T, Gondo Y, Steinberg MH, Hirose N, Atzmon G, Ruvkun G, Baldwin CT, Perls TT
PLoS One. 2009;4(12):e8210 - PMID: 20011587 - PMCID: PMC2788130 - DOI: 10.1371/journal.pone.0008210

Targeted mutagenesis in zebrafish using customized zinc-finger nucleases.

Foley JE, Maeder ML, Pearlberg J, Joung JK, Peterson RT, Yeh JR
Nat Protoc. 2009;4(12):1855-67 - PMID: 20010934 - PMCID: PMC2814337 - DOI: 10.1038/nprot.2009.209

Plant science. DNA binding made easy.

Voytas DF, Joung JK
Science. 2009;326(5959):1491-2 - PMID: 20007890 - DOI: 10.1126/science.1183604

Flip-flop-induced relaxation of bending energy: implications for membrane remodeling.

Bruckner RJ, Mansy SS, Ricardo A, Mahadevan L, Szostak JW
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Common variants at five new loci associated with early-onset inflammatory bowel disease.

Imielinski M, Baldassano RN, Griffiths A, Russell RK, Annese V, Dubinsky M, Kugathasan S, Bradfield JP, Walters TD, Sleiman P, Kim CE, Muise A, Wang K, Glessner JT, Saeed S, Zhang H, Frackelton EC, Hou C, Flory JH, Otieno G, Chiavacci RM, Grundmeier R, Castro M, Latiano A, Dallapiccola B, Stempak J, Abrams DJ, Taylor K, McGovern D, , Silber G, Wrobel I, Quiros A, , Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, Brant SR, Silverberg MS, Taylor KD, Barmuda MM, Bitton A, Dasso ...
Nat Genet. 2009;41(12):1335-40 - PMID: 19915574 - PMCID: PMC3267927 - DOI: 10.1038/ng.489

PrimerBank: a resource of human and mouse PCR primer pairs for gene expression detection and quantification.

Spandidos A, Wang X, Wang H, Seed B
Nucleic Acids Res. 2009;38(Database issue):D792-9 - PMID: 19906719 - PMCID: PMC2808898 - DOI: 10.1093/nar/gkp1005

C. elegans major fats are stored in vesicles distinct from lysosome-related organelles.

O'Rourke EJ, Soukas AA, Carr CE, Ruvkun G
Cell Metab. 2009;10(5):430-5 - PMID: 19883620 - PMCID: PMC2921818 - DOI: 10.1016/j.cmet.2009.10.002

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43.

Maslowski KM, Vieira AT, Ng A, Kranich J, Sierro F, Yu D, Schilter HC, Rolph MS, Mackay F, Artis D, Xavier RJ, Teixeira MM, Mackay CR
Nature. 2009;461(7268):1282-6 - PMID: 19865172 - PMCID: PMC3256734 - DOI: 10.1038/nature08530

Autophagy, immunity and human disease.

Heath RJ, Xavier RJ
Curr Opin Gastroenterol. 2009;25(6):512-20 - PMID: 19826372 - PMCID: PMC2849745 - DOI: 10.1097/MOG.0b013e32833104f1

Oligomerized pool engineering (OPEN): an 'open-source' protocol for making customized zinc-finger arrays.

Maeder ML, Thibodeau-Beganny S, Sander JD, Voytas DF, Joung JK
Nat Protoc. 2009;4(10):1471-501 - PMID: 19798082 - PMCID: PMC2858690 - DOI: 10.1038/nprot.2009.98

Efficient and rapid template-directed nucleic acid copying using 2'-amino-2',3'-dideoxyribonucleoside-5'-phosphorimidazolide monomers.

Schrum JP, Ricardo A, Krishnamurthy M, Blain JC, Szostak JW
J Am Chem Soc. 2009;131(40):14560-70 - PMID: 19757789 - PMCID: PMC2759813 - DOI: 10.1021/ja906557v

Identification of antifungal compounds active against Candida albicans using an improved high-throughput Caenorhabditis elegans assay.

Okoli I, Coleman JJ, Tampakakis E, Tempakakis E, An WF, Holson E, Wagner F, Conery AL, Larkins-Ford J, Wu G, Stern A, Ausubel FM, Mylonakis E
PLoS One. 2009;4(9):e7025 - PMID: 19750012 - PMCID: PMC2737148 - DOI: 10.1371/journal.pone.0007025

Crohn's disease-associated adherent-invasive E. coli are selectively favoured by impaired autophagy to replicate intracellularly.

Lapaquette P, Glasser AL, Huett A, Xavier RJ, Darfeuille-Michaud A
Cell Microbiol. 2009;12(1):99-113 - PMID: 19747213 - PMCID: PMC3743084 - DOI: 10.1111/j.1462-5822.2009.01381.x

Reconstructing the emergence of cellular life through the synthesis of model protocells.

Mansy SS, Szostak JW
Cold Spring Harb Symp Quant Biol. 2009;74:47-54 - PMID: 19734203 - DOI: 10.1101/sqb.2009.74.014

Validation of the riboleukogram to detect ventilator-associated pneumonia after severe injury.

Cobb JP, Moore EE, Hayden DL, Minei JP, Cuschieri J, Yang J, Li Q, Lin N, Brownstein BH, Hennessy L, Mason PH, Schierding WS, Dixon DJ, Tompkins RG, Warren HS, Schoenfeld DA, Maier RV
Ann Surg. 2009;250(4):531-9 - PMID: 19730236 - PMCID: PMC3047595 - DOI: 10.1097/SLA.0b013e3181b8fbd5

Effect of insulin levels on the phosphorylation of specific amino acid residues in IRS-1: implications for burn-induced insulin resistance.

Lu XM, Hamrahi VF, Tompkins RG, Fischman AJ
Int J Mol Med. 2009;24(4):531-8 - PMID: 19724894 - PMCID: PMC4084762

A genome-wide genetic screen for host factors required for hepatitis C virus propagation.

Li Q, Brass AL, Ng A, Hu Z, Xavier RJ, Liang TJ, Elledge SJ
Proc Natl Acad Sci U S A. 2009;106(38):16410-5 - PMID: 19717417 - PMCID: PMC2752535 - DOI: 10.1073/pnas.0907439106

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Ricardo A, Szostak JW
Sci Am. 2009;301(3):54-61 - PMID: 19708528

Preliminary evidence for the effects of morphine on posttraumatic stress disorder symptoms in one- to four-year-olds with burns.

Stoddard FJ, Sorrentino EA, Ceranoglu TA, Saxe G, Murphy JM, Drake JE, Ronfeldt H, White GW, Kagan J, Snidman N, Sheridan RL, Tompkins RG
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Conformational analysis of DNA repair intermediates by time-resolved fluorescence spectroscopy.

Lin S, Horning DP, Szostak JW, Chaput JC
J Phys Chem A. 2009;113(35):9585-7 - PMID: 19673467 - PMCID: PMC2733762 - DOI: 10.1021/jp906746w

Chemical tools for dissecting bacterial physiology and virulence.

Stanley SA, Hung DT
Biochemistry. 2009;48(37):8776-86 - PMID: 19653697 - DOI: 10.1021/bi9009083

Microarray analysis suggests that burn injury results in mitochondrial dysfunction in human skeletal muscle.

Tzika AA, Mintzopoulos D, Mindrinos M, Zhang J, Rahme LG, Tompkins RG
Int J Mol Med. 2009;24(3):387-92 - PMID: 19639232 - PMCID: PMC3207251

Productive steps toward an antimicrobial targeting virulence.

Barczak AK, Hung DT
Curr Opin Microbiol. 2009;12(5):490-6 - PMID: 19631578 - PMCID: PMC2763366 - DOI: 10.1016/j.mib.2009.06.012

Formation of protocell-like vesicles in a thermal diffusion column.

Budin I, Bruckner RJ, Szostak JW
J Am Chem Soc. 2009;131(28):9628-9 - PMID: 19601679 - PMCID: PMC2710859 - DOI: 10.1021/ja9029818

Mannose-binding lectin and innate immunity.

Ip WK, Takahashi K, Ezekowitz RA, Stuart LM
Immunol Rev. 2009;230(1):9-21 - PMID: 19594626 - DOI: 10.1111/j.1600-065X.2009.00789.x

A genomic score prognostic of outcome in trauma patients.

Warren HS, Elson CM, Hayden DL, Schoenfeld DA, Cobb JP, Maier RV, Moldawer LL, Moore EE, Harbrecht BG, Pelak K, Cuschieri J, Herndon DN, Jeschke MG, Finnerty CC, Brownstein BH, Hennessy L, Mason PH, Tompkins RG,
Mol Med. 2009;15(7-8):220-7 - PMID: 19593405 - PMCID: PMC2707513 - DOI: 10.2119/molmed.2009.00027

Cell polarity factor Par3 binds SPTLC1 and modulates monocyte serine palmitoyltransferase activity and chemotaxis.

Tamehiro N, Mujawar Z, Zhou S, Zhuang DZ, Hornemann T, von Eckardstein A, Fitzgerald ML
J Biol Chem. 2009;284(37):24881-90 - PMID: 19592499 - PMCID: PMC2757191 - DOI: 10.1074/jbc.M109.014365

Autophagy at the gut interface: mucosal responses to stress and the consequences for inflammatory bowel diseases.

Huett A, Xavier RJ
Inflamm Bowel Dis. 2010;16(1):152-74 - PMID: 19575363 - PMCID: PMC3954538 - DOI: 10.1002/ibd.20991

Single-molecule imaging of an in vitro-evolved RNA aptamer reveals homogeneous ligand binding kinetics.

Elenko MP, Szostak JW, van Oijen AM
J Am Chem Soc. 2009;131(29):9866-7 - PMID: 19572753 - PMCID: PMC2716146 - DOI: 10.1021/ja901880v

High-throughput screen for novel antimicrobials using a whole animal infection model.

Moy TI, Conery AL, Larkins-Ford J, Wu G, Mazitschek R, Casadei G, Lewis K, Carpenter AE, Ausubel FM
ACS Chem Biol. 2009;4(7):527-33 - PMID: 19572548 - PMCID: PMC2745594 - DOI: 10.1021/cb900084v

Gene targeting of a disease-related gene in human induced pluripotent stem and embryonic stem cells.

Zou J, Maeder ML, Mali P, Pruett-Miller SM, Thibodeau-Beganny S, Chou BK, Chen G, Ye Z, Park IH, Daley GQ, Porteus MH, Joung JK, Cheng L
Cell Stem Cell. 2009;5(1):97-110 - PMID: 19540188 - PMCID: PMC2720132 - DOI: 10.1016/j.stem.2009.05.023

A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants.

Curran SP, Wu X, Riedel CG, Ruvkun G
Nature. 2009;459(7250):1079-84 - PMID: 19506556 - PMCID: PMC2716045 - DOI: 10.1038/nature08106

Modulation of allergen-specific T-lymphocyte function by virus-like particles decorated with HLA class II molecules.

Leb VM, Jahn-Schmid B, Kueng HJ, Schmetterer KG, Haiderer D, Neunkirchner A, Fischer GF, Hartl A, Thalhamer J, Steinberger P, Bohle B, Seed B, Pickl WF
J Allergy Clin Immunol. 2009;124(1):121-8 - PMID: 19500826 - DOI: 10.1016/j.jaci.2009.04.008

An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia.

Benita Y, Kikuchi H, Smith AD, Zhang MQ, Chung DC, Xavier RJ
Nucleic Acids Res. 2009;37(14):4587-602 - PMID: 19491311 - PMCID: PMC2724271 - DOI: 10.1093/nar/gkp425

Origins of life: Systems chemistry on early Earth.

Szostak JW
Nature. 2009;459(7244):171-2 - PMID: 19444196 - DOI: 10.1038/459171a

Enhancing the performance of a point-of-care CD4+ T-cell counting microchip through monocyte depletion for HIV/AIDS diagnostics.

Cheng X, Gupta A, Chen C, Tompkins RG, Rodriguez W, Toner M
Lab Chip. 2009;9(10):1357-64 - PMID: 19417901 - PMCID: PMC4064257 - DOI: 10.1039/b818813k

High-frequency modification of plant genes using engineered zinc-finger nucleases.

Townsend JA, Wright DA, Winfrey RJ, Fu F, Maeder ML, Joung JK, Voytas DF
Nature. 2009;459(7245):442-5 - PMID: 19404258 - PMCID: PMC2743854 - DOI: 10.1038/nature07845

Long-term superior performance of a stem cell/hepatocyte device for the treatment of acute liver failure.

Yagi H, Parekkadan B, Suganuma K, Soto-Gutierrez A, Tompkins RG, Tilles AW, Yarmush ML
Tissue Eng Part A. 2009;15(11):3377-88 - PMID: 19397469 - PMCID: PMC2792056 - DOI: 10.1089/ten.TEA.2008.0681

Retraction for Litovchick and Szostak. "Selection of cyclic peptide aptamers to HCV IRES RNA using mRNA display".

Litovchick A, Szostak JW
Proc Natl Acad Sci U S A. 2009;106(17):7263 - PMID: 19380733 - PMCID: PMC2678432 - DOI: 10.1073/pnas.0903110106

The cytoskeletal scaffold Shank3 is recruited to pathogen-induced actin rearrangements.

Huett A, Leong JM, Podolsky DK, Xavier RJ
Exp Cell Res. 2009;315(12):2001-11 - PMID: 19371741 - PMCID: PMC2693461 - DOI: 10.1016/j.yexcr.2009.04.003

Development of a second-generation antiandrogen for treatment of advanced prostate cancer.

Tran C, Ouk S, Clegg NJ, Chen Y, Watson PA, Arora V, Wongvipat J, Smith-Jones PM, Yoo D, Kwon A, Wasielewska T, Welsbie D, Chen CD, Higano CS, Beer TM, Hung DT, Scher HI, Jung ME, Sawyers CL
Science. 2009;324(5928):787-90 - PMID: 19359544 - PMCID: PMC2981508 - DOI: 10.1126/science.1168175

Preparation of large monodisperse vesicles.

Zhu TF, Szostak JW
PLoS One. 2009;4(4):e5009 - PMID: 19347043 - PMCID: PMC2661144 - DOI: 10.1371/journal.pone.0005009

Using PATIMDB to create bacterial transposon insertion mutant libraries.

Urbach JM, Wei T, Liberati N, Grenfell-Lee D, Villanueva J, Wu G, Ausubel FM
Curr Protoc Mol Biol. 2009;Chapter 19:Unit 19.7 - PMID: 19343706 - PMCID: PMC4492697 - DOI: 10.1002/0471142727.mb1907s86

A novel hybrid yeast-human network analysis reveals an essential role for FNBP1L in antibacterial autophagy.

Huett A, Ng A, Cao Z, Kuballa P, Komatsu M, Daly MJ, Podolsky DK, Xavier RJ
J Immunol. 2009;182(8):4917-30 - PMID: 19342671 - PMCID: PMC2752416 - DOI: 10.4049/jimmunol.0803050

Coupled growth and division of model protocell membranes.

Zhu TF, Szostak JW
J Am Chem Soc. 2009;131(15):5705-13 - PMID: 19323552 - PMCID: PMC2669828 - DOI: 10.1021/ja900919c

Enzymatic primer-extension with glycerol-nucleoside triphosphates on DNA templates.

Chen JJ, Tsai CH, Cai X, Horhota AT, McLaughlin LW, Szostak JW
PLoS One. 2009;4(3):e4949 - PMID: 19305495 - PMCID: PMC2654545 - DOI: 10.1371/journal.pone.0004949

A functional genomic screen identifies cellular cofactors of hepatitis C virus replication.

Tai AW, Benita Y, Peng LF, Kim SS, Sakamoto N, Xavier RJ, Chung RT
Cell Host Microbe. 2009;5(3):298-307 - PMID: 19286138 - PMCID: PMC2756022 - DOI: 10.1016/j.chom.2009.02.001

Selective activation of nuclear factor kappa B in the cochlea by sensory and inflammatory stress.

Adams JC, Seed B, Lu N, Landry A, Xavier RJ
Neuroscience. 2009;160(2):530-9 - PMID: 19285117 - PMCID: PMC2673023 - DOI: 10.1016/j.neuroscience.2009.02.073

Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans.

Soukas AA, Kane EA, Carr CE, Melo JA, Ruvkun G
Genes Dev. 2009;23(4):496-511 - PMID: 19240135 - PMCID: PMC2648650 - DOI: 10.1101/gad.1775409

Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis.

Festen EA, Goyette P, Scott R, Annese V, Zhernakova A, Lian J, Lefèbvre C, Brant SR, Cho JH, Silverberg MS, Taylor KD, de Jong DJ, Stokkers PC, Mcgovern D, Palmieri O, Achkar JP, Xavier RJ, Daly MJ, Duerr RH, Wijmenga C, Weersma RK, Rioux JD
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Rapid mutation of endogenous zebrafish genes using zinc finger nucleases made by Oligomerized Pool ENgineering (OPEN).

Foley JE, Yeh JR, Maeder ML, Reyon D, Sander JD, Peterson RT, Joung JK
PLoS One. 2009;4(2):e4348 - PMID: 19198653 - PMCID: PMC2634973 - DOI: 10.1371/journal.pone.0004348

The G protein-coupled receptor FSHR-1 is required for the Caenorhabditis elegans innate immune response.

Powell JR, Kim DH, Ausubel FM
Proc Natl Acad Sci U S A. 2009;106(8):2782-7 - PMID: 19196974 - PMCID: PMC2650343 - DOI: 10.1073/pnas.0813048106

Temporal global expression data reveal known and novel salicylate-impacted processes and regulators mediating powdery mildew growth and reproduction on Arabidopsis.

Chandran D, Tai YC, Hather G, Dewdney J, Denoux C, Burgess DG, Ausubel FM, Speed TP, Wildermuth MC
Plant Physiol. 2009;149(3):1435-51 - PMID: 19176722 - PMCID: PMC2649394 - DOI: 10.1104/pp.108.132985

Biosynthesis of the Caenorhabditis elegans dauer pheromone.

Butcher RA, Ragains JR, Li W, Ruvkun G, Clardy J, Mak HY
Proc Natl Acad Sci U S A. 2009;106(6):1875-9 - PMID: 19174521 - PMCID: PMC2631283 - DOI: 10.1073/pnas.0810338106

Lack of lymphatic vessel phenotype in LYVE-1/CD44 double knockout mice.

Luong MX, Tam J, Lin Q, Hagendoorn J, Moore KJ, Padera TP, Seed B, Fukumura D, Kucherlapati R, Jain RK
J Cell Physiol. 2009;219(2):430-7 - PMID: 19170073 - PMCID: PMC2665001 - DOI: 10.1002/jcp.21686

Pseudomonas aeruginosa infection of zebrafish involves both host and pathogen determinants.

Clatworthy AE, Lee JS, Leibman M, Kostun Z, Davidson AJ, Hung DT
Infect Immun. 2009;77(4):1293-303 - PMID: 19168742 - PMCID: PMC2663173 - DOI: 10.1128/IAI.01181-08

N2'-->p3' phosphoramidate glycerol nucleic acid as a potential alternative genetic system.

Chen JJ, Cai X, Szostak JW
J Am Chem Soc. 2009;131(6):2119-21 - PMID: 19166350 - PMCID: PMC2722806 - DOI: 10.1021/ja809069b

Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease.

McCarroll SA, Huett A, Kuballa P, Chilewski SD, Landry A, Goyette P, Zody MC, Hall JL, Brant SR, Cho JH, Duerr RH, Silverberg MS, Taylor KD, Rioux JD, Altshuler D, Daly MJ, Xavier RJ
Nat Genet. 2008;40(9):1107-12 - PMID: 19165925 - PMCID: PMC2731799 - DOI: 10.1038/ng.215

Differential requirement for CARMA1 in agonist-selected T-cell development.

Medoff BD, Sandall BP, Landry A, Nagahama K, Mizoguchi A, Luster AD, Xavier RJ
Eur J Immunol. 2009;39(1):78-84 - PMID: 19130560 - PMCID: PMC2747028 - DOI: 10.1002/eji.200838734

Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway.

Hitomi J, Christofferson DE, Ng A, Yao J, Degterev A, Xavier RJ, Yuan J
Cell. 2008;135(7):1311-23 - PMID: 19109899 - PMCID: PMC2621059 - DOI: 10.1016/j.cell.2008.10.044

A comprehensive collection of experimentally validated primers for Polymerase Chain Reaction quantitation of murine transcript abundance.

Spandidos A, Wang X, Wang H, Dragnev S, Thurber T, Seed B
BMC Genomics. 2008;9:633 - PMID: 19108745 - PMCID: PMC2631021 - DOI: 10.1186/1471-2164-9-633

Glucosinolate metabolites required for an Arabidopsis innate immune response.

Clay NK, Adio AM, Denoux C, Jander G, Ausubel FM
Science. 2008;323(5910):95-101 - PMID: 19095898 - PMCID: PMC2630859 - DOI: 10.1126/science.1164627

Sensitive, specific polymorphism discovery in bacteria using massively parallel sequencing.

Nusbaum C, Ohsumi TK, Gomez J, Aquadro J, Victor TC, Warren RM, Hung DT, Birren BW, Lander ES, Jaffe DB
Nat Methods. 2008;6(1):67-9 - PMID: 19079253 - PMCID: PMC2613166 - DOI: 10.1038/nmeth.1286

Gene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis.

Goyette P, Lefebvre C, Ng A, Brant SR, Cho JH, Duerr RH, Silverberg MS, Taylor KD, Latiano A, Aumais G, Deslandres C, Jobin G, Annese V, Daly MJ, Xavier RJ, Rioux JD
Mucosal Immunol. 2008;1(2):131-8 - PMID: 19079170 - PMCID: PMC4550306 - DOI: 10.1038/mi.2007.15

Microsporidia are natural intracellular parasites of the nematode Caenorhabditis elegans.

Troemel ER, Félix MA, Whiteman NK, Barrière A, Ausubel FM
PLoS Biol. 2008;6(12):2736-52 - PMID: 19071962 - PMCID: PMC2596862 - DOI: 10.1371/journal.pbio.0060309

A metasystem of framework model organisms to study emergence of new host-microbe adaptations.

Gopalan S, Ausubel FM
PLoS One. 2008;3(12):e3891 - PMID: 19066631 - PMCID: PMC2588659 - DOI: 10.1371/journal.pone.0003891

Are topical antimicrobials effective against bacteria that are highly resistant to systemic antibiotics?

Neely AN, Gardner J, Durkee P, Warden GD, Greenhalgh DG, Gallagher JJ, Herndon DN, Tompkins RG, Kagan RJ
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An affinity-based scoring scheme for predicting DNA-binding activities of modularly assembled zinc-finger proteins.

Sander JD, Zaback P, Joung JK, Voytas DF, Dobbs D
Nucleic Acids Res. 2008;37(2):506-15 - PMID: 19056825 - PMCID: PMC2632909 - DOI: 10.1093/nar/gkn962

Large-scale multiplexed quantitative discovery proteomics enabled by the use of an (18)O-labeled "universal" reference sample.

Qian WJ, Liu T, Petyuk VA, Gritsenko MA, Petritis BO, Polpitiya AD, Kaushal A, Xiao W, Finnerty CC, Jeschke MG, Jaitly N, Monroe ME, Moore RJ, Moldawer LL, Davis RW, Tompkins RG, Herndon DN, Camp DG, Smith RD,
J Proteome Res. 2009;8(1):290-9 - PMID: 19053531 - PMCID: PMC2752204 - DOI: 10.1021/pr800467r

HIF-1alpha and HIF-2alpha have divergent roles in colon cancer.

Imamura T, Kikuchi H, Herraiz MT, Park DY, Mizukami Y, Mino-Kenduson M, Lynch MP, Rueda BR, Benita Y, Xavier RJ, Chung DC
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On the level: IRGM gene function is all about expression.

Huett A, McCarroll SA, Daly MJ, Xavier RJ
Autophagy. 2009;5(1):96-9 - PMID: 19029815 - PMCID: PMC3204672

Deficiency of mannose-binding lectin greatly increases antibody response in a mouse model of vaccination.

Guttormsen HK, Stuart LM, Shi L, Carroll MC, Chen J, Kasper DL, Ezekowitz RA, Takahashi K
Clin Immunol. 2008;130(3):264-71 - PMID: 18996748 - PMCID: PMC2660855 - DOI: 10.1016/j.clim.2008.09.012

Fat metabolism links germline stem cells and longevity in C. elegans.

Wang MC, O'Rourke EJ, Ruvkun G
Science. 2008;322(5903):957-60 - PMID: 18988854 - PMCID: PMC2760269 - DOI: 10.1126/science.1162011

Role for beta-catenin and HOX transcription factors in Caenorhabditis elegans and mammalian host epithelial-pathogen interactions.

Irazoqui JE, Ng A, Xavier RJ, Ausubel FM
Proc Natl Acad Sci U S A. 2008;105(45):17469-74 - PMID: 18981407 - PMCID: PMC2582251 - DOI: 10.1073/pnas.0809527105

ABCA12 maintains the epidermal lipid permeability barrier by facilitating formation of ceramide linoleic esters.

Zuo Y, Zhuang DZ, Han R, Isaac G, Tobin JJ, McKee M, Welti R, Brissette JL, Fitzgerald ML, Freeman MW
J Biol Chem. 2008;283(52):36624-35 - PMID: 18957418 - PMCID: PMC2605993 - DOI: 10.1074/jbc.M807377200

Loss of SR-A and CD36 activity reduces atherosclerotic lesion complexity without abrogating foam cell formation in hyperlipidemic mice.

Manning-Tobin JJ, Moore KJ, Seimon TA, Bell SA, Sharuk M, Alvarez-Leite JI, de Winther MP, Tabas I, Freeman MW
Arterioscler Thromb Vasc Biol. 2008;29(1):19-26 - PMID: 18948635 - PMCID: PMC2666043 - DOI: 10.1161/ATVBAHA.108.176644

Early supplemental parenteral nutrition is associated with increased infectious complications in critically ill trauma patients.

Sena MJ, Utter GH, Cuschieri J, Maier RV, Tompkins RG, Harbrecht BG, Moore EE, O'Keefe GE
J Am Coll Surg. 2008;207(4):459-67 - PMID: 18926446 - PMCID: PMC4002002 - DOI: 10.1016/j.jamcollsurg.2008.04.028

The most conserved genome segments for life detection on Earth and other planets.

Isenbarger TA, Carr CE, Johnson SS, Finney M, Church GM, Gilbert W, Zuber MT, Ruvkun G
Orig Life Evol Biosph. 2008;38(6):517-33 - PMID: 18853276 - DOI: 10.1007/s11084-008-9148-z

Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant.

Kuballa P, Huett A, Rioux JD, Daly MJ, Xavier RJ
PLoS One. 2008;3(10):e3391 - PMID: 18852889 - PMCID: PMC2566595 - DOI: 10.1371/journal.pone.0003391

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells.

Cadwell K, Liu JY, Brown SL, Miyoshi H, Loh J, Lennerz JK, Kishi C, Kc W, Carrero JA, Hunt S, Stone CD, Brunt EM, Xavier RJ, Sleckman BP, Li E, Mizushima N, Stappenbeck TS, Virgin HW
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Impact of oxandrolone treatment on acute outcomes after severe burn injury.

Pham TN, Klein MB, Gibran NS, Arnoldo BD, Gamelli RL, Silver GM, Jeschke MG, Finnerty CC, Tompkins RG, Herndon DN
J Burn Care Res. 2008;29(6):902-6 - PMID: 18849836 - PMCID: PMC3958934 - DOI: 10.1097/BCR.0b013e31818ba14d

The perfect storm of tiny RNAs.

Ruvkun G
Nat Med. 2008;14(10):1041-5 - PMID: 18841145 - DOI: 10.1038/nm1008-1041

Selection of cyclic peptide aptamers to HCV IRES RNA using mRNA display.

Litovchick A, Szostak JW
Proc Natl Acad Sci U S A. 2008;105(40):15293-8 - PMID: 18824687 - PMCID: PMC2556359 - DOI: 10.1073/pnas.0805837105

A microfluidics approach for the isolation of nucleated red blood cells (NRBCs) from the peripheral blood of pregnant women.

Huang R, Barber TA, Schmidt MA, Tompkins RG, Toner M, Bianchi DW, Kapur R, Flejter WL
Prenat Diagn. 2008;28(10):892-9 - PMID: 18821715 - PMCID: PMC4482103 - DOI: 10.1002/pd.2079

Zinc Finger Database (ZiFDB): a repository for information on C2H2 zinc fingers and engineered zinc-finger arrays.

Fu F, Sander JD, Maeder M, Thibodeau-Beganny S, Joung JK, Dobbs D, Miller L, Voytas DF
Nucleic Acids Res. 2008;37(Database issue):D279-83 - PMID: 18812396 - PMCID: PMC2686427 - DOI: 10.1093/nar/gkn606

The AtrbohD-mediated oxidative burst elicited by oligogalacturonides in Arabidopsis is dispensable for the activation of defense responses effective against Botrytis cinerea.

Galletti R, Denoux C, Gambetta S, Dewdney J, Ausubel FM, De Lorenzo G, Ferrari S
Plant Physiol. 2008;148(3):1695-706 - PMID: 18790995 - PMCID: PMC2577270 - DOI: 10.1104/pp.108.127845

Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7.

Fischer SE, Butler MD, Pan Q, Ruvkun G
Nature. 2008;455(7212):491-6 - PMID: 18784652 - PMCID: PMC2756026 - DOI: 10.1038/nature07274

Thermostability of model protocell membranes.

Mansy SS, Szostak JW
Proc Natl Acad Sci U S A. 2008;105(36):13351-5 - PMID: 18768808 - PMCID: PMC2528865 - DOI: 10.1073/pnas.0805086105

CARMA3 mediates lysophosphatidic acid-stimulated cytokine secretion by bronchial epithelial cells.

Medoff BD, Landry AL, Wittbold KA, Sandall BP, Derby MC, Cao Z, Adams JC, Xavier RJ
Am J Respir Cell Mol Biol. 2008;40(3):286-94 - PMID: 18757306 - PMCID: PMC2645526 - DOI: 10.1165/rcmb.2008-0129OC

RNA interference screen for human genes associated with West Nile virus infection.

Krishnan MN, Ng A, Sukumaran B, Gilfoy FD, Uchil PD, Sultana H, Brass AL, Adametz R, Tsui M, Qian F, Montgomery RR, Lev S, Mason PW, Koski RA, Elledge SJ, Xavier RJ, Agaisse H, Fikrig E
Nature. 2008;455(7210):242-5 - PMID: 18690214 - PMCID: PMC3136529 - DOI: 10.1038/nature07207

Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification.

Maeder ML, Thibodeau-Beganny S, Osiak A, Wright DA, Anthony RM, Eichtinger M, Jiang T, Foley JE, Winfrey RJ, Townsend JA, Unger-Wallace E, Sander JD, Müller-Lerch F, Fu F, Pearlberg J, Göbel C, Dassie JP, Pruett-Miller SM, Porteus MH, Sgroi DC, Iafrate AJ, Dobbs D, McCray PB, Cathomen T, Voytas DF, Joung JK
Mol Cell. 2008;31(2):294-301 - PMID: 18657511 - PMCID: PMC2535758 - DOI: 10.1016/j.molcel.2008.06.016

Hoxc6 is overexpressed in gastrointestinal carcinoids and interacts with JunD to regulate tumor growth.

Fujiki K, Duerr EM, Kikuchi H, Ng A, Xavier RJ, Mizukami Y, Imamura T, Kulke MH, Chung DC
Gastroenterology. 2008;135(3):907-16, 916.e1-2 - PMID: 18655788 - PMCID: PMC3777410 - DOI: 10.1053/j.gastro.2008.06.034

Genome-wide association studies: a new window into immune-mediated diseases.

Xavier RJ, Rioux JD
Nat Rev Immunol. 2008;8(8):631-43 - PMID: 18654571 - PMCID: PMC2750781 - DOI: 10.1038/nri2361

MAST3: a novel IBD risk factor that modulates TLR4 signaling.

Labbé C, Goyette P, Lefebvre C, Stevens C, Green T, Tello-Ruiz MK, Cao Z, Landry AL, Stempak J, Annese V, Latiano A, Brant SR, Duerr RH, Taylor KD, Cho JH, Steinhart AH, Daly MJ, Silverberg MS, Xavier RJ, Rioux JD
Genes Immun. 2008;9(7):602-12 - PMID: 18650832 - PMCID: PMC2574831 - DOI: 10.1038/gene.2008.57

Quantitation of autophagy by luciferase release assay.

Ketteler R, Seed B
Autophagy. 2008;4(6):801-6 - PMID: 18641457 - PMCID: PMC2910585

Detection of mutations in EGFR in circulating lung-cancer cells.

Maheswaran S, Sequist LV, Nagrath S, Ulkus L, Brannigan B, Collura CV, Inserra E, Diederichs S, Iafrate AJ, Bell DW, Digumarthy S, Muzikansky A, Irimia D, Settleman J, Tompkins RG, Lynch TJ, Toner M, Haber DA
N Engl J Med. 2008;359(4):366-77 - PMID: 18596266 - PMCID: PMC3551471 - DOI: 10.1056/NEJMoa0800668

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.

Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, Brant SR, Silverberg MS, Taylor KD, Barmada MM, Bitton A, Dassopoulos T, Datta LW, Green T, Griffiths AM, Kistner EO, Murtha MT, Regueiro MD, Rotter JI, Schumm LP, Steinhart AH, Targan SR, Xavier RJ, , Libioulle C, Sandor C, Lathrop M, Belaiche J, Dewit O, Gut I, Heath S, Laukens D, Mni M, Rutgeerts P, Van Gossum A, Zelenika D, Franchimont D, Hugot JP, de Vos M, Vermeire S, Louis E, , , Cardon LR, Anderson CA, Drummond H, Nimm ...
Nat Genet. 2008;40(8):955-62 - PMID: 18587394 - PMCID: PMC2574810 - DOI: 10.1038/ng.175

Attenuation of Pseudomonas aeruginosa virulence by medicinal plants in a Caenorhabditis elegans model system.

Adonizio A, Leal SM, Ausubel FM, Mathee K
J Med Microbiol. 2008;57(Pt 7):809-13 - PMID: 18566137 - DOI: 10.1099/jmm.0.47802-0

Tiny RNA: Where do we come from? What are we? Where are we going?

Ruvkun G
Trends Plant Sci. 2008;13(7):313-6 - PMID: 18562240 - DOI: 10.1016/j.tplants.2008.05.005

Temporal cytokine profiles in severely burned patients: a comparison of adults and children.

Finnerty CC, Jeschke MG, Herndon DN, Gamelli R, Gibran N, Klein M, Silver G, Arnoldo B, Remick D, Tompkins RG,
Mol Med. 2008;14(9-10):553-60 - PMID: 18548133 - PMCID: PMC2424320 - DOI: 10.2119/2007-00132.Finnerty

Zinc-finger nucleases: the next generation emerges.

Cathomen T, Joung JK
Mol Ther. 2008;16(7):1200-7 - PMID: 18545224 - DOI: 10.1038/mt.2008.114

Animal models for host-pathogen interactions.

Lemaitre B, Ausubel FM
Curr Opin Microbiol. 2008;11(3):249-50 - PMID: 18539076 - DOI: 10.1016/j.mib.2008.05.002

Template-directed synthesis of a genetic polymer in a model protocell.

Mansy SS, Schrum JP, Krishnamurthy M, Tobé S, Treco DA, Szostak JW
Nature. 2008;454(7200):122-5 - PMID: 18528332 - PMCID: PMC2743009 - DOI: 10.1038/nature07018

The microRNA miR-1 regulates a MEF-2-dependent retrograde signal at neuromuscular junctions.

Simon DJ, Madison JM, Conery AL, Thompson-Peer KL, Soskis M, Ruvkun GB, Kaplan JM, Kim JK
Cell. 2008;133(5):903-15 - PMID: 18510933 - PMCID: PMC2553566 - DOI: 10.1016/j.cell.2008.04.035

Murine intramyocellular lipids quantified by NMR act as metabolic biomarkers in burn trauma.

Tzika AA, Astrakas LG, Cao H, Mintzopoulos D, Zhang Q, Padfield K, Yu H, Mindrinos MN, Rahme LG, Tompkins RG
Int J Mol Med. 2008;21(6):825-32 - PMID: 18506378

Genetic identification of HSD-1, a conserved steroidogenic enzyme that directs larval development in Caenorhabditis elegans.

Patel DS, Fang LL, Svy DK, Ruvkun G, Li W
Development. 2008;135(13):2239-49 - PMID: 18495818 - DOI: 10.1242/dev.016972

Neither hide nor hair: the difficulty of identifying useful disease biomarkers.

Huett A, Xavier RJ
Gastroenterology. 2008;134(7):2164-8 - PMID: 18486617 - DOI: 10.1053/j.gastro.2008.04.013

Estimating glutathione synthesis with deuterated water: a model for peptide biosynthesis.

Cabral CB, Bullock KH, Bischoff DJ, Tompkins RG, Yu YM, Kelleher JK
Anal Biochem. 2008;379(1):40-4 - PMID: 18486587 - PMCID: PMC4065382 - DOI: 10.1016/j.ab.2008.04.042

SPTLC1 binds ABCA1 to negatively regulate trafficking and cholesterol efflux activity of the transporter.

Tamehiro N, Zhou S, Okuhira K, Benita Y, Brown CE, Zhuang DZ, Latz E, Hornemann T, von Eckardstein A, Xavier RJ, Freeman MW, Fitzgerald ML
Biochemistry. 2008;47(23):6138-47 - PMID: 18484747 - PMCID: PMC2504083 - DOI: 10.1021/bi800182t

Unexpected failure rates for modular assembly of engineered zinc fingers.

Ramirez CL, Foley JE, Wright DA, Müller-Lerch F, Rahman SH, Cornu TI, Winfrey RJ, Sander JD, Fu F, Townsend JA, Cathomen T, Voytas DF, Joung JK
Nat Methods. 2008;5(5):374-5 - PMID: 18446154 - DOI: 10.1038/nmeth0508-374

Activation of defense response pathways by OGs and Flg22 elicitors in Arabidopsis seedlings.

Denoux C, Galletti R, Mammarella N, Gopalan S, Werck D, De Lorenzo G, Ferrari S, Ausubel FM, Dewdney J
Mol Plant. 2008;1(3):423-45 - PMID: 19825551 - PMCID: PMC2954645 - DOI: 10.1093/mp/ssn019

The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi.

Gabel HW, Ruvkun G
Nat Struct Mol Biol. 2008;15(5):531-3 - PMID: 18438419 - PMCID: PMC2910399 - DOI: 10.1038/nsmb.1411

Silanizing glassware.

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Silanizing glassware.

Seed B
Curr Protoc Protein Sci. 2001;Appendix 3:Appendix 3E - PMID: 18429072 - DOI: 10.1002/0471140864.psa03es13

Identification of Caenorhabditis elegans genes regulating longevity using enhanced RNAi-sensitive strains.

Samuelson AV, Klimczak RR, Thompson DB, Carr CE, Ruvkun G
Cold Spring Harb Symp Quant Biol. 2008;72:489-97 - PMID: 18419309 - DOI: 10.1101/sqb.2007.72.068

Spinophilin and the immune synapse.

Seed B, Xavier R
J Cell Biol. 2008;181(2):181-3 - PMID: 18411314 - PMCID: PMC2315665 - DOI: 10.1083/jcb.200803120

Ribosomal synthesis of N-methyl peptides.

Subtelny AO, Hartman MC, Szostak JW
J Am Chem Soc. 2008;130(19):6131-6 - PMID: 18402453 - PMCID: PMC2728122 - DOI: 10.1021/ja710016v

Comparing insertion libraries in two Pseudomonas aeruginosa strains to assess gene essentiality.

Liberati NT, Urbach JM, Thurber TK, Wu G, Ausubel FM
Methods Mol Biol. 2008;416:153-69 - PMID: 18392966 - DOI: 10.1007/978-1-59745-321-9_10

A pathway sensor for genome-wide screens of intracellular proteolytic cleavage.

Ketteler R, Sun Z, Kovacs KF, He WW, Seed B
Genome Biol. 2008;9(4):R64 - PMID: 18387192 - PMCID: PMC2643935 - DOI: 10.1186/gb-2008-9-4-r64

Microfluidic leukocyte isolation for gene expression analysis in critically ill hospitalized patients.

Russom A, Sethu P, Irimia D, Mindrinos MN, Calvano SE, Garcia I, Finnerty C, Tannahill C, Abouhamze A, Wilhelmy J, López MC, Baker HV, Herndon DN, Lowry SF, Maier RV, Davis RW, Moldawer LL, Tompkins RG, Toner M,
Clin Chem. 2008;54(5):891-900 - PMID: 18375483 - PMCID: PMC4011019 - DOI: 10.1373/clinchem.2007.099150

Models of Caenorhabditis elegans infection by bacterial and fungal pathogens.

Powell JR, Ausubel FM
Methods Mol Biol. 2008;415:403-27 - PMID: 18370168 - DOI: 10.1007/978-1-59745-570-1_24

Increased uncoupling protein 1 mRNA expression in mice brown adipose tissue after burn injury.

Zhang Q, Ma B, Fischman AJ, Tompkins RG, Carter EA
J Burn Care Res. 2008;29(2):358-62 - PMID: 18354294 - DOI: 10.1097/BCR.0b013e318166739c

Burn-related metabolic and signaling changes in rat brain.

Zhang Q, Carter EA, Ma B, Fischman AJ, Tompkins RG
J Burn Care Res. 2008;29(2):346-52 - PMID: 18354292 - DOI: 10.1097/BCR.0b013e3181667387

A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein.

Schöbel S, Neumann S, Hertweck M, Dislich B, Kuhn PH, Kremmer E, Seed B, Baumeister R, Haass C, Lichtenthaler SF
J Biol Chem. 2008;283(21):14257-68 - PMID: 18353773 - DOI: 10.1074/jbc.M801531200

Comparison of zinc finger nucleases for use in gene targeting in mammalian cells.

Pruett-Miller SM, Connelly JP, Maeder ML, Joung JK, Porteus MH
Mol Ther. 2008;16(4):707-17 - PMID: 18334988 - DOI: 10.1038/mt.2008.20

Metal-ion catalyzed polymerization in the eutectic phase in water-ice: a possible approach to template-directed RNA polymerization.

Monnard PA, Szostak JW
J Inorg Biochem. 2008;102(5-6):1104-11 - PMID: 18329104 - DOI: 10.1016/j.jinorgbio.2008.01.026

Engineering Cys2His2 zinc finger domains using a bacterial cell-based two-hybrid selection system.

Thibodeau-Beganny S, Joung JK
Methods Mol Biol. 2008;408:317-34 - PMID: 18314590

Defining molecular classifications and targets in gastroenteropancreatic neuroendocrine tumors through DNA microarray analysis.

Duerr EM, Mizukami Y, Ng A, Xavier RJ, Kikuchi H, Deshpande V, Warshaw AL, Glickman J, Kulke MH, Chung DC
Endocr Relat Cancer. 2008;15(1):243-56 - PMID: 18310291 - DOI: 10.1677/ERC-07-0194

Equilibrium separation and filtration of particles using differential inertial focusing.

Di Carlo D, Edd JF, Irimia D, Tompkins RG, Toner M
Anal Chem. 2008;80(6):2204-11 - PMID: 18275222 - DOI: 10.1021/ac702283m

Autophagy as an important process in gut homeostasis and Crohn's disease pathogenesis.

Xavier RJ, Huett A, Rioux JD
Gut. 2008;57(6):717-20 - PMID: 18272545 - PMCID: PMC2735854 - DOI: 10.1136/gut.2007.134254

Silanizing glassware.

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DAF-16-dependent suppression of immunity during reproduction in Caenorhabditis elegans.

Miyata S, Begun J, Troemel ER, Ausubel FM
Genetics. 2008;178(2):903-18 - PMID: 18245330 - PMCID: PMC2248360 - DOI: 10.1534/genetics.107.083923

Invention, innovation, entrepreneurship in academic medical centers.

Toner M, Tompkins RG
Surgery. 2008;143(2):168-71 - PMID: 18242329 - PMCID: PMC2408552 - DOI: 10.1016/j.surg.2007.11.004

Influence of age on the association of retinol-binding protein 4 with metabolic syndrome.

Gavi S, Qurashi S, Stuart LM, Lau R, Melendez MM, Mynarcik DC, McNurlan MA, Gelato MC
Obesity (Silver Spring). 2008;16(4):893-5 - PMID: 18239568 - DOI: 10.1038/oby.2007.138

Silanizing glassware.

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Curr Protoc Cell Biol. 2001;Appendix 3:Appendix 3E - PMID: 18228287 - DOI: 10.1002/0471143030.cba03es08

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The practice of venous thromboembolism prophylaxis in the major trauma patient.

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Conjugating berberine to a multidrug efflux pump inhibitor creates an effective antimicrobial.

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A systems biology analysis of the Drosophila phagosome.

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A bioartificial liver device secreting interleukin-1 receptor antagonist for the treatment of hepatic failure in rats.

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Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways.

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Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging.

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A genomewide search for ribozymes reveals an HDV-like sequence in the human CPEB3 gene.

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Peroxidase-dependent apoplastic oxidative burst in Arabidopsis required for pathogen resistance.

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Putting food on the public health table: Making food security relevant to regional health authorities.

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A unique short-chain dehydrogenase/reductase in Arabidopsis glucose signaling and abscisic acid biosynthesis and functions.

Cheng WH, Endo A, Zhou L, Penney J, Chen HC, Arroyo A, Leon P, Nambara E, Asami T, Seo M, Koshiba T, Sheen J
Plant Cell. 2002;14(11):2723-43 - PMID: 12417697 - PMCID: PMC152723

Two-component signal transduction pathways in Arabidopsis.

Hwang I, Chen HC, Sheen J
Plant Physiol. 2002;129(2):500-15 - PMID: 12068096 - PMCID: PMC161668 - DOI: 10.1104/pp.005504

Calcium signaling through protein kinases. The Arabidopsis calcium-dependent protein kinase gene family.

Cheng SH, Willmann MR, Chen HC, Sheen J
Plant Physiol. 2002;129(2):469-85 - PMID: 12068094 - PMCID: PMC1540234 - DOI: 10.1104/pp.005645

Sugar sensing and signaling in plants.

Rolland F, Moore B, Sheen J
Plant Cell. 2002;14 Suppl:S185-205 - PMID: 12045277 - PMCID: PMC151255

Phosphorelay and transcription control in cytokinin signal transduction.

Sheen J
Science. 2002;296(5573):1650-2 - PMID: 12040183 - DOI: 10.1126/science.1071883

MAP kinase signalling cascade in Arabidopsis innate immunity.

Asai T, Tena G, Plotnikova J, Willmann MR, Chiu WL, Gomez-Gomez L, Boller T, Ausubel FM, Sheen J
Nature. 2002;415(6875):977-83 - PMID: 11875555 - DOI: 10.1038/415977a

Signal transduction in maize and Arabidopsis mesophyll protoplasts.

Sheen J
Plant Physiol. 2001;127(4):1466-75 - PMID: 11743090 - PMCID: PMC1540179

Plant mitogen-activated protein kinase signaling cascades.

Tena G, Asai T, Chiu WL, Sheen J
Curr Opin Plant Biol. 2001;4(5):392-400 - PMID: 11597496

Dissection of abscisic acid signal transduction pathways in barley aleurone layers.

Shen Q, Gomez-Cadenas A, Zhang P, Walker-Simmons MK, Sheen J, Ho TH
Plant Mol Biol. 2001;47(3):437-48 - PMID: 11587514

Two-component circuitry in Arabidopsis cytokinin signal transduction.

Hwang I, Sheen J
Nature. 2001;413(6854):383-9 - PMID: 11574878 - DOI: 10.1038/35096500

Molecular identification of phenylalanine ammonia-lyase as a substrate of a specific constitutively active Arabidopsis CDPK expressed in maize protoplasts.

Cheng SH, Sheen J, Gerrish C, Bolwell GP
FEBS Lett. 2001;503(2-3):185-8 - PMID: 11513879

Isotopic assays for reporter gene activity.

Kingston RE, Sheen J, Moore D
Curr Protoc Pharmacol. 2001;Chapter 6:Unit 6.4 - PMID: 21965075 - DOI: 10.1002/0471141755.ph0604s05

Mesophyll-specific, light and metabolic regulation of the C4 PPCZm1 promoter in transgenic maize.

Kausch AP, Owen TP, Zachwieja SJ, Flynn AR, Sheen J
Plant Mol Biol. 2001;45(1):1-15 - PMID: 11247600

The role of hexokinase in plant sugar signal transduction and growth and development.

Xiao W, Sheen J, Jang JC
Plant Mol Biol. 2000;44(4):451-61 - PMID: 11197321

Fumonisin B1-induced cell death in arabidopsis protoplasts requires jasmonate-, ethylene-, and salicylate-dependent signaling pathways.

Asai T, Stone JM, Heard JE, Kovtun Y, Yorgey P, Sheen J, Ausubel FM
Plant Cell. 2000;12(10):1823-36 - PMID: 11041879 - PMCID: PMC149122

Analysis of Arabidopsis glucose insensitive mutants, gin5 and gin6, reveals a central role of the plant hormone ABA in the regulation of plant vegetative development by sugar.

Arenas-Huertero F, Arroyo A, Zhou L, Sheen J, León P
Genes Dev. 2000;14(16):2085-96 - PMID: 10950871 - PMCID: PMC316855

Differential Expression in Bundle Sheath and Mesophyll Cells of Maize of Genes for Photosystem II Components Encoded by the Plastid Genome.

Sheen JY, Bogorad L
Plant Physiol. 1988;86(4):1020-6 - PMID: 16666025 - PMCID: PMC1054621

Expression of the ribulose-1,5-bisphosphate carboxylase large subunit gene and three small subunit genes in two cell types of maize leaves.

Sheen JY, Bogorad L
EMBO J. 1986;5(13):3417-22 - PMID: 16453739 - PMCID: PMC1167374

Differential expression of the ribulose bisphosphate carboxylase large subunit gene in bundle sheath and mesophyll cells of developing maize leaves is influenced by light.

Sheen JY, Bogorad L
Plant Physiol. 1985;79(4):1072-6 - PMID: 16664532 - PMCID: PMC1075029

Unequal crossing-over associated with asymmetrical synapsis between nomadic elements in the Drosophila melanogaster genome.

Goldberg ML, Sheen JY, Gehring WJ, Green MM
Proc Natl Acad Sci U S A. 1983;80(16):5017-21 - PMID: 16593354 - PMCID: PMC384179

Transient expression assays for quantifying signaling output.

Niu Y, Sheen J
Methods Mol Biol. 2012;876:195-206 - PMID: 22576097 - DOI: 10.1007/978-1-61779-809-2_16

Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening.

Stanley SA, Schmidt Grant S, Kawate T, Iwase N, Shimizu M, Wivagg C, Silvis M, Kazyanskaya E, Aquadro J, Golas A, Fitzgerald M, Dai H, Zhang L, Hung DT
ACS Chem Biol. 2012;7(8):1377-84 - PMID: 22577943 - PMCID: PMC3560293 - DOI: 10.1021/cb300151m

Nondegradative Role of Atg5-Atg12/ Atg16L1 Autophagy Protein Complex in Antiviral Activity of Interferon Gamma.

Hwang S, Maloney NS, Bruinsma MW, Goel G, Duan E, Zhang L, Shrestha B, Diamond MS, Dani A, Sosnovtsev SV, Green KY, Lopez-Otin C, Xavier RJ, Thackray LB, Virgin HW
Cell Host Microbe. 2012;11(4):397-409 - PMID: 22520467 - PMCID: PMC3348177 - DOI: 10.1016/j.chom.2012.03.002

Tribbles 2 (Trib2) is a novel regulator of toll-like receptor 5 signaling.

Wei SC, Rosenberg IM, Cao Z, Huett AS, Xavier RJ, Podolsky DK
Inflamm Bowel Dis. 2012;18(5):877-88 - PMID: 22271508 - PMCID: PMC3881418 - DOI: 10.1002/ibd.22883

Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1.

Zhao Y, Alonso C, Ballester I, Song JH, Chang SY, Guleng B, Arihiro S, Murray PJ, Xavier R, Kobayashi KS, Reinecker HC
Inflamm Bowel Dis. 2011;18(4):603-12 - PMID: 21887730 - PMCID: PMC3594873 - DOI: 10.1002/ibd.21851

Caspase 8 inhibits programmed necrosis by processing CYLD.

O'Donnell MA, Perez-Jimenez E, Oberst A, Ng A, Massoumi R, Xavier R, Green DR, Ting AT
Nat Cell Biol. 2011;13(12):1437-42 - PMID: 22037414 - PMCID: PMC3229661 - DOI: 10.1038/ncb2362

Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine.

Cadwell K, Patel KK, Maloney NS, Liu TC, Ng AC, Storer CE, Head RD, Xavier R, Stappenbeck TS, Virgin HW
Cell. 2010;141(7):1135-45 - PMID: 20602997 - PMCID: PMC2908380 - DOI: 10.1016/j.cell.2010.05.009

Differential expression of microRNA (miRNA) in chordoma reveals a role for miRNA-1 in Met expression.

Duan Z, Choy E, Nielsen GP, Rosenberg A, Iafrate J, Yang C, Schwab J, Mankin H, Xavier R, Hornicek FJ
J Orthop Res. 2010;28(6):746-52 - PMID: 20041488 - DOI: 10.1002/jor.21055

Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.

Raychaudhuri S, Plenge RM, Rossin EJ, Ng AC, , Purcell SM, Sklar P, Scolnick EM, Xavier RJ, Altshuler D, Daly MJ
PLoS Genet. 2009;5(6):e1000534 - PMID: 19557189 - PMCID: PMC2694358 - DOI: 10.1371/journal.pgen.1000534

Building complex biological networks based upon model organisms: mapping the human autophagy interactome via a hybrid yeast-human protein interaction network.

Huett A, Xavier R
Autophagy. 2009;5(6):884-6 - PMID: 19535904

Identification of Atg5-dependent transcriptional changes and increases in mitochondrial mass in Atg5-deficient T lymphocytes.

Stephenson LM, Miller BC, Ng A, Eisenberg J, Zhao Z, Cadwell K, Graham DB, Mizushima NN, Xavier R, Virgin HW, Swat W
Autophagy. 2009;5(5):625-35 - PMID: 19276668 - PMCID: PMC3737142

Rassf family of tumor suppressor polypeptides.

Avruch J, Xavier R, Bardeesy N, Zhang XF, Praskova M, Zhou D, Xia F
J Biol Chem. 2008;284(17):11001-5 - PMID: 19091744 - PMCID: PMC2670104 - DOI: 10.1074/jbc.R800073200

The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells.

Zhou D, Medoff BD, Chen L, Li L, Zhang XF, Praskova M, Liu M, Landry A, Blumberg RS, Boussiotis VA, Xavier R, Avruch J
Proc Natl Acad Sci U S A. 2008;105(51):20321-6 - PMID: 19073936 - PMCID: PMC2600581 - DOI: 10.1073/pnas.0810773105

The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response.

Friedman CS, O'Donnell MA, Legarda-Addison D, Ng A, Cárdenas WB, Yount JS, Moran TM, Basler CF, Komuro A, Horvath CM, Xavier R, Ting AT
EMBO Rep. 2008;9(9):930-6 - PMID: 18636086 - PMCID: PMC2529351 - DOI: 10.1038/embor.2008.136

SNPping away at the pathogenesis of Crohn's disease.

Huett A, Xavier R
Inflamm Bowel Dis. 2008;14(1):136-7 - PMID: 17941076 - DOI: 10.1002/ibd.20306

Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development.

Cotta-de-Almeida V, Westerberg L, Maillard MH, Onaldi D, Wachtel H, Meelu P, Chung UI, Xavier R, Alt FW, Snapper SB
Proc Natl Acad Sci U S A. 2007;104(39):15424-9 - PMID: 17878299 - PMCID: PMC2000553 - DOI: 10.1073/pnas.0706881104

DLGH1 is a negative regulator of T-lymphocyte proliferation.

Stephenson LM, Sammut B, Graham DB, Chan-Wang J, Brim KL, Huett AS, Miletic AV, Kloeppel T, Landry A, Xavier R, Swat W
Mol Cell Biol. 2007;27(21):7574-81 - PMID: 17724087 - PMCID: PMC2169038 - DOI: 10.1128/MCB.00439-07

Vav proteins control MyD88-dependent oxidative burst.

Miletic AV, Graham DB, Montgrain V, Fujikawa K, Kloeppel T, Brim K, Weaver B, Schreiber R, Xavier R, Swat W
Blood. 2006;109(8):3360-8 - PMID: 17158234 - PMCID: PMC1852252 - DOI: 10.1182/blood-2006-07-033662

Vav proteins control MyD88-dependent oxidative burst.

Miletic AV, Graham DB, Montgrain V, Fujikawa K, Kloeppel T, Brim K, Weaver B, Schreiber R, Xavier R, Swat W
Blood. 2006;109(8):3360-8 - PMID: 17158234 - PMCID: PMC1852252 - DOI: 10.1182/blood-2006-07-033662

Bcl10 is phosphorylated on Ser138 by Ca2+/calmodulin-dependent protein kinase II.

Ishiguro K, Ando T, Goto H, Xavier R
Mol Immunol. 2006;44(8):2095-100 - PMID: 17052756 - DOI: 10.1016/j.molimm.2006.09.012

Centaurin beta1 down-regulates nucleotide-binding oligomerization domains 1- and 2-dependent NF-kappaB activation.

Yamamoto-Furusho JK, Barnich N, Xavier R, Hisamatsu T, Podolsky DK
J Biol Chem. 2006;281(47):36060-70 - PMID: 17005562 - DOI: 10.1074/jbc.M602383200

Paeonol attenuates TNBS-induced colitis by inhibiting NF-kappaB and STAT1 transactivation.

Ishiguro K, Ando T, Maeda O, Hasegawa M, Kadomatsu K, Ohmiya N, Niwa Y, Xavier R, Goto H
Toxicol Appl Pharmacol. 2006;217(1):35-42 - PMID: 16928387 - DOI: 10.1016/j.taap.2006.07.002

Immune cell transcriptome datasets reveal novel leukocyte subset-specific genes and genes associated with allergic processes.

Liu SM, Xavier R, Good KL, Chtanova T, Newton R, Sisavanh M, Zimmer S, Deng C, Silva DG, Frost MJ, Tangye SG, Rolph MS, Mackay CR
J Allergy Clin Immunol. 2006;118(2):496-503 - PMID: 16890777 - DOI: 10.1016/j.jaci.2006.04.040

A molecular-properties-based approach to understanding PDZ domain proteins and PDZ ligands.

Giallourakis C, Cao Z, Green T, Wachtel H, Xie X, Lopez-Illasaca M, Daly M, Rioux J, Xavier R
Genome Res. 2006;16(8):1056-72 - PMID: 16825666 - PMCID: PMC1524865 - DOI: 10.1101/gr.5285206

Nore1B regulates TCR signaling via Ras and Carma1.

Ishiguro K, Avruch J, Landry A, Qin S, Ando T, Goto H, Xavier R
Cell Signal. 2006;18(10):1647-54 - PMID: 16520020 - PMCID: PMC3204664 - DOI: 10.1016/j.cellsig.2006.01.015

Isolation and analysis of lipid rafts in cell-cell interactions.

Landry A, Xavier R
Methods Mol Biol. 2006;341:251-82 - PMID: 16799204 - DOI: 10.1385/1-59745-113-4:251

Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognition.

Barnich N, Aguirre JE, Reinecker HC, Xavier R, Podolsky DK
J Cell Biol. 2005;170(1):21-6 - PMID: 15998797 - PMCID: PMC2171381 - DOI: 10.1083/jcb.200502153

GRIM-19 interacts with nucleotide oligomerization domain 2 and serves as downstream effector of anti-bacterial function in intestinal epithelial cells.

Barnich N, Hisamatsu T, Aguirre JE, Xavier R, Reinecker HC, Podolsky DK
J Biol Chem. 2005;280(19):19021-6 - PMID: 15753091 - DOI: 10.1074/jbc.M413776200

Bioluminescence resonance energy transfer identify scaffold protein CNK1 interactions in intact cells.

Lopez-Ilasaca MA, Bernabe-Ortiz JC, Na SY, Dzau VJ, Xavier RJ
FEBS Lett. 2005;579(3):648-54 - PMID: 15670823 - DOI: 10.1016/j.febslet.2004.12.039

PDZ domains and the politics of polarity in lymphocytes.

Xavier R, Seed B
Immunity. 2005;22(6):655-6 - PMID: 15963778 - DOI: 10.1016/j.immuni.2005.06.003

Commensal flora: wolf in sheep's clothing.

Xavier R, Podolsky DK
Gastroenterology. 2005;128(4):1122-6 - PMID: 15825094

Large-scale screens for cDNAs with in vivo activity.

Ting A, Lichtenthaler S, Xavier R, Na SY, Rabizadeh S, Holmes T, Seed B
Novartis Found Symp. 2005;267:219-29; discussion 229-30 - PMID: 15999809

Wave2 activates serum response element via its VCA region and functions downstream of Rac.

Ishiguro K, Cao Z, Ilasca ML, Ando T, Xavier R
Exp Cell Res. 2004;301(2):331-7 - PMID: 15530867 - DOI: 10.1016/j.yexcr.2004.09.003

Discs large (Dlg1) complexes in lymphocyte activation.

Xavier R, Rabizadeh S, Ishiguro K, Andre N, Ortiz JB, Wachtel H, Morris DG, Lopez-Ilasaca M, Shaw AC, Swat W, Seed B
J Cell Biol. 2004;166(2):173-8 - PMID: 15263016 - PMCID: PMC2172307 - DOI: 10.1083/jcb.200309044

The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death.

Rabizadeh S, Xavier RJ, Ishiguro K, Bernabeortiz J, Lopez-Ilasaca M, Khokhlatchev A, Mollahan P, Pfeifer GP, Avruch J, Seed B
J Biol Chem. 2004;279(28):29247-54 - PMID: 15075335 - DOI: 10.1074/jbc.M401699200

Chemotherapy- and radiotherapy-induced intestinal damage is regulated by intestinal trefoil factor.

Beck PL, Wong JF, Li Y, Swaminathan S, Xavier RJ, Devaney KL, Podolsky DK
Gastroenterology. 2004;126(3):796-808 - PMID: 14988834

Paradoxical roles of different nitric oxide synthase isoforms in colonic injury.

Beck PL, Xavier R, Wong J, Ezedi I, Mashimo H, Mizoguchi A, Mizoguchi E, Bhan AK, Podolsky DK
Am J Physiol Gastrointest Liver Physiol. 2004;286(1):G137-47 - PMID: 14665440 - DOI: 10.1152/ajpgi.00309.2003

Homer-3 regulates activation of serum response element in T cells via its EVH1 domain.

Ishiguro K, Xavier R
Blood. 2003;103(6):2248-56 - PMID: 14645007 - DOI: 10.1182/blood-2003-08-2671

Colonic epithelial functional phenotype varies with type and phase of experimental colitis.

Mizoguchi E, Xavier RJ, Reinecker HC, Uchino H, Bhan AK, Podolsky DK, Mizoguchi A
Gastroenterology. 2003;125(1):148-61 - PMID: 12851880

Essential role for Vav1 in activation, but not development, of gammadelta T cells.

Swat W, Xavier R, Mizoguchi A, Mizoguchi E, Fredericks J, Fujikawa K, Bhan AK, Alt FW
Int Immunol. 2003;15(2):215-21 - PMID: 12578851

Transforming growth factor-beta mediates intestinal healing and susceptibility to injury in vitro and in vivo through epithelial cells.

Beck PL, Rosenberg IM, Xavier RJ, Koh T, Wong JF, Podolsky DK
Am J Pathol. 2003;162(2):597-608 - PMID: 12547717 - PMCID: PMC1851153

Decreased bone density in splenectomized Gaucher patients receiving enzyme replacement therapy.

Schiffmann R, Mankin H, Dambrosia JM, Xavier RJ, Kreps C, Hill SC, Barton NW, Rosenthal DI
Blood Cells Mol Dis. 2002;28(2):288-96 - PMID: 12064924

Identification of a novel Ras-regulated proapoptotic pathway.

Khokhlatchev A, Rabizadeh S, Xavier R, Nedwidek M, Chen T, Zhang XF, Seed B, Avruch J
Curr Biol. 2002;12(4):253-65 - PMID: 11864565

Role of tumor necrosis factor receptor 2 (TNFR2) in colonic epithelial hyperplasia and chronic intestinal inflammation in mice.

Mizoguchi E, Mizoguchi A, Takedatsu H, Cario E, de Jong YP, Ooi CJ, Xavier RJ, Terhorst C, Podolsky DK, Bhan AK
Gastroenterology. 2002;122(1):134-44 - PMID: 11781288

Autophagy suppresses interleukin-1? (IL-1?) signaling by activation of p62 degradation via lysosomal and proteasomal pathways.

Lee J, Kim HR, Quinley C, Kim J, Gonzalez-Navajas J, Xavier R, Raz E
J Biol Chem. 2011;287(6):4033-40 - PMID: 22167182 - PMCID: PMC3281713 - DOI: 10.1074/jbc.M111.280065

Penetration Resistance: PKR's Other Talent.

Lacy-Hulbert A, Stuart LM
Immunity. 2012;36(5):695-6 - PMID: 22633454 - DOI: 10.1016/j.immuni.2012.05.010

Cytokinin signaling networks

Hwang I., Sheen J., Mueller B.
Annu Rev Plant Biology. . 2012;63:353-380

Improved Somatic Mutagenesis in Zebrafish Using Transcription Activator-Like Effector Nucleases (TALENs).

Moore FE, Reyon D, Sander JD, Martinez SA, Blackburn JS, Khayter C, Ramirez CL, Joung JK, Langenau DM
PLoS One. 2012;7(5):e37877 - PMID: 22655075 - PMCID: PMC3360007 - DOI: 10.1371/journal.pone.0037877

Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response.

Liberati NT, Fitzgerald KA, Kim DH, Feinbaum R, Golenbock DT, Ausubel FM
Proc Natl Acad Sci U S A. 2004;101(17):6593-8 - PMID: 15123841 - PMCID: PMC404090 - DOI: 10.1073/pnas.0308625101

Arabidopsis local resistance to Botrytis cinerea involves salicylic acid and camalexin and requires EDS4 and PAD2, but not SID2, EDS5 or PAD4.

Ferrari S, Plotnikova JM, De Lorenzo G, Ausubel FM
Plant J. 2003;35(2):193-205 - PMID: 12848825

Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens.

Garsin DA, Villanueva JM, Begun J, Kim DH, Sifri CD, Calderwood SB, Ruvkun G, Ausubel FM
Science. 2003;300(5627):1921 - PMID: 12817143 - DOI: 10.1126/science.1080147

Caenorhabditis elegans innate immune response triggered by Salmonella enterica requires intact LPS and is mediated by a MAPK signaling pathway.

Aballay A, Drenkard E, Hilbun LR, Ausubel FM
Curr Biol. 2003;13(1):47-52 - PMID: 12526744

A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity.

Kim DH, Feinbaum R, Alloing G, Emerson FE, Garsin DA, Inoue H, Tanaka-Hino M, Hisamoto N, Matsumoto K, Tan MW, Ausubel FM
Science. 2002;297(5581):623-6 - PMID: 12142542 - DOI: 10.1126/science.1073759

Pseudomonas biofilm formation and antibiotic resistance are linked to phenotypic variation.

Drenkard E, Ausubel FM
Nature. 2002;416(6882):740-3 - PMID: 11961556 - DOI: 10.1038/416740a

Isochorismate synthase is required to synthesize salicylic acid for plant defence.

Wildermuth MC, Dewdney J, Wu G, Ausubel FM
Nature. 2001;414(6863):562-5 - PMID: 11734859 - DOI: 10.1038/35107108

A simple model host for identifying Gram-positive virulence factors.

Garsin DA, Sifri CD, Mylonakis E, Qin X, Singh KV, Murray BE, Calderwood SB, Ausubel FM
Proc Natl Acad Sci U S A. 2001;98(19):10892-7 - PMID: 11535834 - PMCID: PMC58570 - DOI: 10.1073/pnas.191378698

Programmed cell death mediated by ced-3 and ced-4 protects Caenorhabditis elegans from Salmonella typhimurium-mediated killing.

Aballay A, Ausubel FM
Proc Natl Acad Sci U S A. 2001;98(5):2735-9 - PMID: 11226309 - PMCID: PMC30208 - DOI: 10.1073/pnas.041613098

Killing of Caenorhabditis elegans by Pseudomonas aeruginosa used to model mammalian bacterial pathogenesis.

Tan MW, Mahajan-Miklos S, Ausubel FM
Proc Natl Acad Sci U S A. 1999;96(2):715-20 - PMID: 9892699 - PMCID: PMC15202

Molecular mechanisms of bacterial virulence elucidated using a Pseudomonas aeruginosa-Caenorhabditis elegans pathogenesis model.

Mahajan-Miklos S, Tan MW, Rahme LG, Ausubel FM
Cell. 1999;96(1):47-56 - PMID: 9989496

Correlation of defense gene induction defects with powdery mildew susceptibility in Arabidopsis enhanced disease susceptibility mutants.

Reuber TL, Plotnikova JM, Dewdney J, Rogers EE, Wood W, Ausubel FM
Plant J. 1998;16(4):473-85 - PMID: 9881167

Use of model plant hosts to identify Pseudomonas aeruginosa virulence factors.

Rahme LG, Tan MW, Le L, Wong SM, Tompkins RG, Calderwood SB, Ausubel FM
Proc Natl Acad Sci U S A. 1997;94(24):13245-50 - PMID: 9371831 - PMCID: PMC24294

Phytoalexin-deficient mutants of Arabidopsis reveal that PAD4 encodes a regulatory factor and that four PAD genes contribute to downy mildew resistance.

Glazebrook J, Zook M, Mert F, Kagan I, Rogers EE, Crute IR, Holub EB, Hammerschmidt R, Ausubel FM
Genetics. 1997;146(1):381-92 - PMID: 9136026 - PMCID: PMC1207952

Arabidopsis enhanced disease susceptibility mutants exhibit enhanced susceptibility to several bacterial pathogens and alterations in PR-1 gene expression.

Rogers EE, Ausubel FM
Plant Cell. 1997;9(3):305-16 - PMID: 9090877 - PMCID: PMC156920 - DOI: 10.1105/tpc.9.3.305

Isolation of Arabidopsis mutants with enhanced disease susceptibility by direct screening.

Glazebrook J, Rogers EE, Ausubel FM
Genetics. 1996;143(2):973-82 - PMID: 8725243 - PMCID: PMC1207353

Common virulence factors for bacterial pathogenicity in plants and animals.

Rahme LG, Stevens EJ, Wolfort SF, Shao J, Tompkins RG, Ausubel FM
Science. 1995;268(5219):1899-902 - PMID: 7604262

The A. thaliana disease resistance gene RPS2 encodes a protein containing a nucleotide-binding site and leucine-rich repeats.

Mindrinos M, Katagiri F, Yu GL, Ausubel FM
Cell. 1994;78(6):1089-99 - PMID: 7923358

Isolation of phytoalexin-deficient mutants of Arabidopsis thaliana and characterization of their interactions with bacterial pathogens.

Glazebrook J, Ausubel FM
Proc Natl Acad Sci U S A. 1994;91(19):8955-9 - PMID: 8090752 - PMCID: PMC44725

Programmed cell death in plants: a pathogen-triggered response activated coordinately with multiple defense functions.

Greenberg JT, Guo A, Klessig DF, Ausubel FM
Cell. 1994;77(4):551-63 - PMID: 8187175

Arabidopsis mutations at the RPS2 locus result in loss of resistance to Pseudomonas syringae strains expressing the avirulence gene avrRpt2.

Yu GL, Katagiri F, Ausubel FM
Mol Plant Microbe Interact. 1993;6(4):434-43 - PMID: 8400373

A procedure for mapping Arabidopsis mutations using co-dominant ecotype-specific PCR-based markers.

Konieczny A, Ausubel FM
Plant J. 1993;4(2):403-10 - PMID: 8106085

copia-like retrotransposons are ubiquitous among plants.

Voytas DF, Cummings MP, Koniczny A, Ausubel FM, Rodermel SR
Proc Natl Acad Sci U S A. 1992;89(15):7124-8 - PMID: 1379734 - PMCID: PMC49658

Cloning the Arabidopsis GA1 Locus by Genomic Subtraction.

Sun T, Goodman HM, Ausubel FM
Plant Cell. 1992;4(2):119-128 - PMID: 12297643 - PMCID: PMC160113 - DOI: 10.1105/tpc.4.2.119

Induction of Arabidopsis defense genes by virulent and avirulent Pseudomonas syringae strains and by a cloned avirulence gene.

Dong X, Mindrinos M, Davis KR, Ausubel FM
Plant Cell. 1991;3(1):61-72 - PMID: 1824335 - PMCID: PMC159979 - DOI: 10.1105/tpc.3.1.61

The structure, distribution and evolution of the Ta1 retrotransposable element family of Arabidopsis thaliana.

Voytas DF, Konieczny A, Cummings MP, Ausubel FM
Genetics. 1990;126(3):713-21 - PMID: 2174394 - PMCID: PMC1204225

Genomic subtraction for cloning DNA corresponding to deletion mutations.

Straus D, Ausubel FM
Proc Natl Acad Sci U S A. 1990;87(5):1889-93 - PMID: 2408039 - PMCID: PMC53589

Arabidopsis thaliana mutant that develops as a light-grown plant in the absence of light.

Chory J, Peto C, Feinbaum R, Pratt L, Ausubel F
Cell. 1989;58(5):991-9 - PMID: 2776216

A copia-like transposable element family in Arabidopsis thaliana.

Voytas DF, Ausubel FM
Nature. 1988;336(6196):242-4 - PMID: 2904123 - DOI: 10.1038/336242a0

Isolation of a higher eukaryotic telomere from Arabidopsis thaliana.

Richards EJ, Ausubel FM
Cell. 1988;53(1):127-36 - PMID: 3349525

Two-component regulatory systems responsive to environmental stimuli share strongly conserved domains with the nitrogen assimilation regulatory genes ntrB and ntrC.

Nixon BT, Ronson CW, Ausubel FM
Proc Natl Acad Sci U S A. 1986;83(20):7850-4 - PMID: 3020561 - PMCID: PMC386820

A Rhizobium meliloti symbiotic regulatory gene.

Szeto WW, Zimmerman JL, Sundaresan V, Ausubel FM
Cell. 1984;36(4):1035-43 - PMID: 6423287

Activation of Klebsiella pneumoniae and Rhizobium meliloti nitrogenase promoters by gln (ntr) regulatory proteins.

Sundaresan V, Ow DW, Ausubel FM
Proc Natl Acad Sci U S A. 1983;80(13):4030-4 - PMID: 6306658 - PMCID: PMC394194

Promoters regulated by the glnG (ntrC) and nifA gene products share a heptameric consensus sequence in the -15 region.

Ow DW, Sundaresan V, Rothstein DM, Brown SE, Ausubel FM
Proc Natl Acad Sci U S A. 1983;80(9):2524-8 - PMID: 6133280 - PMCID: PMC393858

Klebsiella pneumoniae nifA product activates the Rhizobium meliloti nitrogenase promoter.

Sundaresan V, Jones JD, Ow DW, Ausubel FM
Nature. 1983;301(5902):728-32 - PMID: 6338395

Regulation of nitrogen metabolism genes by nifA gene product in Klebsiella pneumoniae.

Ow DW, Ausubel FM
Nature. 1983;301(5898):307-13 - PMID: 6337346

Directed transposon Tn5 mutagenesis and complementation analysis of Rhizobium meliloti symbiotic nitrogen fixation genes.

Ruvkun GB, Sundaresan V, Ausubel FM
Cell. 1982;29(2):551-9 - PMID: 6288262

A general method for site-directed mutagenesis in prokaryotes.

Ruvkun GB, Ausubel FM
Nature. 1981;289(5793):85-8 - PMID: 6256652

Interspecies homology of nitrogenase genes.

Ruvkun GB, Ausubel FM
Proc Natl Acad Sci U S A. 1980;77(1):191-5 - PMID: 6987649 - PMCID: PMC348234

Physical map of chromosomal nitrogen fixation (nif) genes of Klebsiella pneumoniae.

Riedel GE, Ausubel FM, Cannon FC
Proc Natl Acad Sci U S A. 1979;76(6):2866-70 - PMID: 379866 - PMCID: PMC383710

Recombinant plasmid that carries part of the nitrogen fixation (nif) gene cluster of Klebsiella pneumoniae.

Cannon FC, Riedel GE, Ausubel FM
Proc Natl Acad Sci U S A. 1977;74(7):2963-7 - PMID: 331321 - PMCID: PMC431364

Photochemically driven redox chemistry induces protocell membrane pearling and division.

Zhu TF, Adamala K, Zhang N, Szostak JW
Proc Natl Acad Sci U S A. 2012;109(25):9828-32 - PMID: 22665773 - PMCID: PMC3382484 - DOI: 10.1073/pnas.1203212109

Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENs.

Cade L, Reyon D, Hwang WY, Tsai SQ, Patel S, Khayter C, Joung JK, Sander JD, Peterson RT, Yeh JR
Nucleic Acids Res. 2012;40(16):8001-10 - PMID: 22684503 - PMCID: PMC3439908 - DOI: 10.1093/nar/gks518

MUT-16 promotes formation of perinuclear Mutator foci required for RNA silencing in the C. elegans germline.

Phillips CM, Montgomery TA, Breen PC, Ruvkun G
Genes Dev. 2012;26(13):1433-44 - PMID: 22713602 - PMCID: PMC3403012 - DOI: 10.1101/gad.193904.112

Stimulation of Host Immune Defenses by a Small Molecule Protects C. elegans from Bacterial Infection.

Pukkila-Worley R, Feinbaum R, Kirienko NV, Larkins-Ford J, Conery AL, Ausubel FM
PLoS Genet. 2012;8(6):e1002733 - PMID: 22719261 - PMCID: PMC3375230 - DOI: 10.1371/journal.pgen.1002733

Perception of volatiles produced by UVC-irradiated plants alters the response to viral infection in naïve neighboring plants.

Yao Y, Danna CH, Ausubel FM, Kovalchuk I
Plant Signal Behav. 2012;7(7):741-5 - PMID: 22751319 - PMCID: PMC3583953 - DOI: 10.4161/psb.20406

Helminth Infection Impairs Autophagy-Mediated Killing of Bacterial Enteropathogens by Macrophages.

Su CW, Cao Y, Zhang M, Kaplan J, Su L, Fu Y, Walker WA, Xavier R, Cherayil BJ, Shi HN
J Immunol. 2012;189(3):1459-66 - PMID: 22732589 - PMCID: PMC3423331 - DOI: 10.4049/jimmunol.1200484

Non-invasive mapping of the gastrointestinal microbiota identifies children with inflammatory bowel disease.

Papa E, Docktor M, Smillie C, Weber S, Preheim SP, Gevers D, Giannoukos G, Ciulla D, Tabbaa D, Ingram J, Schauer DB, Ward DV, Korzenik JR, Xavier RJ, Bousvaros A, Alm EJ
PLoS One. 2012;7(6):e39242 - PMID: 22768065 - PMCID: PMC3387146 - DOI: 10.1371/journal.pone.0039242

Eradication of bacterial persisters with antibiotic-generated hydroxyl radicals.

Schmidt Grant S, Kaufmann BB, Chand NS, Haseley N, Hung DT
Proc Natl Acad Sci U S A. 2012;109(30):12147-52 - PMID: 22778419 - PMCID: PMC3409745 - DOI: 10.1073/pnas.1203735109

EGL-9 Controls C. elegans Host Defense Specificity through Prolyl Hydroxylation-Dependent and -Independent HIF-1 Pathways.

Luhachack LG, Visvikis O, Wollenberg AC, Lacy-Hulbert A, Stuart LM, Irazoqui JE
PLoS Pathog. 2012;8(7):e1002798 - PMID: 22792069 - PMCID: PMC3390412 - DOI: 10.1371/journal.ppat.1002798

Genes Involved in the Evolution of Herbivory By A Leaf-Mining, Drosophilid Fly.

Whiteman NK, Gloss AD, Sackton TB, Groen SC, Humphrey PT, Lapoint RT, Sønderby IE, Halkier BA, Kocks C, Ausubel FM, Pierce NE
Genome Biol Evol. 2012;4(9):900-16 - PMID: 22813779 - PMCID: PMC3516228 - DOI: 10.1093/gbe/evs063

TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria.

Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
Cell. 2012;150(3):606-19 - PMID: 22819539 - PMCID: PMC3660860 - DOI: 10.1016/j.cell.2012.07.007

Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways.

Shore DE, Carr CE, Ruvkun G
PLoS Genet. 2012;8(7):e1002792 - PMID: 22829775 - PMCID: PMC3400582 - DOI: 10.1371/journal.pgen.1002792

Case 23-2012.

Xavier RJ, Gala MK, Bronzo BK, Kelly PJ
N Engl J Med. 2012;367(4):363-73 - PMID: 22830467 - DOI: 10.1056/NEJMcpc1109275

Multicomponent assembly of proposed DNA precursors in water.

Powner MW, Zheng SL, Szostak JW
J Am Chem Soc. 2012;134(33):13889-95 - PMID: 22839703 - PMCID: PMC3424849 - DOI: 10.1021/ja306176n

An interview with Jen Sheen.

Sheen J
Trends Plant Sci. 2012;17(6):321-2 - PMID: 22860262

New insights into siRNA amplification and RNAi.

Zhang C, Ruvkun G
RNA Biol. 2012;9(8):1045-9 - PMID: 22858672 - PMCID: PMC3551858 - DOI: 10.4161/rna.21246

A synthetic biology framework for programming eukaryotic transcription functions.

Khalil AS, Lu TK, Bashor CJ, Ramirez CL, Pyenson NC, Joung JK, Collins JJ
Cell. 2012;150(3):647-58 - PMID: 22863014 - PMCID: PMC3653585 - DOI: 10.1016/j.cell.2012.05.045

Enhanced Tim3 Activity Improves Survival after Influenza Infection.

Cho JL, Roche MI, Sandall B, Brass AL, Seed B, Xavier RJ, Medoff BD
J Immunol. 2012;189(6):2879-89 - PMID: 22875804 - PMCID: PMC3436990 - DOI: 10.4049/jimmunol.1102483

Functional genomic analysis of C. elegans molting.

Frand AR, Russel S, Ruvkun G
PLoS Biol. 2005;3(10):e312 - PMID: 16122351 - PMCID: PMC1233573 - DOI: 10.1371/journal.pbio.0030312

Regulation of Caenorhabditis elegans RNA interference by the daf-2 insulin stress and longevity signaling pathway.

Wang D, Ruvkun G
Cold Spring Harb Symp Quant Biol. 2005;69:429-31 - PMID: 16117677 - DOI: 10.1101/sqb.2004.69.429

Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants.

Wang D, Kennedy S, Conte D, Kim JK, Gabel HW, Kamath RS, Mello CC, Ruvkun G
Nature. 2005;436(7050):593-7 - PMID: 16049496 - DOI: 10.1038/nature04010

Systematic analysis of genes required for synapse structure and function.

Sieburth D, Ch'ng Q, Dybbs M, Tavazoie M, Kennedy S, Wang D, Dupuy D, Rual JF, Hill DE, Vidal M, Ruvkun G, Kaplan JM
Nature. 2005;436(7050):510-7 - PMID: 16049479 - DOI: 10.1038/nature03809

A systematic RNAi screen for longevity genes in C. elegans.

Hamilton B, Dong Y, Shindo M, Liu W, Odell I, Ruvkun G, Lee SS
Genes Dev. 2005;19(13):1544-55 - PMID: 15998808 - PMCID: PMC1172061 - DOI: 10.1101/gad.1308205

The tiny RNA world.

Ruvkun GB
Harvey Lect. 2005;99:1-21 - PMID: 15984549

Analysis of xbx genes in C. elegans.

Efimenko E, Bubb K, Mak HY, Holzman T, Leroux MR, Ruvkun G, Thomas JH, Swoboda P
Development. 2005;132(8):1923-34 - PMID: 15790967 - DOI: 10.1242/dev.01775

Functional genomic analysis of RNA interference in C. elegans.

Kim JK, Gabel HW, Kamath RS, Tewari M, Pasquinelli A, Rual JF, Kennedy S, Dybbs M, Bertin N, Kaplan JM, Vidal M, Ruvkun G
Science. 2005;308(5725):1164-7 - PMID: 15790806 - DOI: 10.1126/science.1109267

MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression.

Mansfield JH, Harfe BD, Nissen R, Obenauer J, Srineel J, Chaudhuri A, Farzan-Kashani R, Zuker M, Pasquinelli AE, Ruvkun G, Sharp PA, Tabin CJ, McManus MT
Nat Genet. 2004;36(10):1079-83 - PMID: 15361871 - DOI: 10.1038/ng1421

Intercellular signaling of reproductive development by the C. elegans DAF-9 cytochrome P450.

Mak HY, Ruvkun G
Development. 2004;131(8):1777-86 - PMID: 15084462 - DOI: 10.1242/dev.01069

The 20 years it took to recognize the importance of tiny RNAs.

Ruvkun G, Wightman B, Ha I
Cell. 2004;116(2 Suppl):S93-6, 2 p following S96 - PMID: 15055593

Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network.

Tewari M, Hu PJ, Ahn JS, Ayivi-Guedehoussou N, Vidalain PO, Li S, Milstein S, Armstrong CM, Boxem M, Butler MD, Busiguina S, Rual JF, Ibarrola N, Chaklos ST, Bertin N, Vaglio P, Edgley ML, King KV, Albert PS, Vandenhaute J, Pandey A, Riddle DL, Ruvkun G, Vidal M
Mol Cell. 2004;13(4):469-82 - PMID: 14992718

A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans.

Kennedy S, Wang D, Ruvkun G
Nature. 2004;427(6975):645-9 - PMID: 14961122 - DOI: 10.1038/nature02302

Unraveling the secrets of the cell.

Komaroff AL, Ruvkun G
Newsweek. 2003;142(23):96 - PMID: 14712576

Identification of many microRNAs that copurify with polyribosomes in mammalian neurons.

Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G
Proc Natl Acad Sci U S A. 2003;101(1):360-5 - PMID: 14691248 - PMCID: PMC314190 - DOI: 10.1073/pnas.2333854100

Functional tests of enhancer conservation between distantly related species.

Ruvinsky I, Ruvkun G
Development. 2003;130(21):5133-42 - PMID: 12944426 - DOI: 10.1242/dev.00711

Activity of the Caenorhabditis elegans UNC-86 POU transcription factor modulates olfactory sensitivity.

Sze JY, Ruvkun G
Proc Natl Acad Sci U S A. 2003;100(16):9560-5 - PMID: 12883006 - PMCID: PMC170957 - DOI: 10.1073/pnas.1530752100

Expression of the 22 nucleotide let-7 heterochronic RNA throughout the Metazoa: a role in life history evolution?

Pasquinelli AE, McCoy A, Jiménez E, Saló E, Ruvkun G, Martindale MQ, Baguñà J
Evol Dev. 2003;5(4):372-8 - PMID: 12823453

Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens.

Garsin DA, Villanueva JM, Begun J, Kim DH, Sifri CD, Calderwood SB, Ruvkun G, Ausubel FM
Science. 2003;300(5627):1921 - PMID: 12817143 - DOI: 10.1126/science.1080147

Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis.

Bashirullah A, Pasquinelli AE, Kiger AA, Perrimon N, Ruvkun G, Thummel CS
Dev Biol. 2003;259(1):1-8 - PMID: 12812783

The Caenorhabditis elegans ems class homeobox gene ceh-2 is required for M3 pharynx motoneuron function.

Aspöck G, Ruvkun G, Bürglin TR
Development. 2003;130(15):3369-78 - PMID: 12810585

Computational and experimental identification of C. elegans microRNAs.

Grad Y, Aach J, Hayes GD, Reinhart BJ, Church GM, Ruvkun G, Kim J
Mol Cell. 2003;11(5):1253-63 - PMID: 12769849

DAF-16 target genes that control C. elegans life-span and metabolism.

Lee SS, Kennedy S, Tolonen AC, Ruvkun G
Science. 2003;300(5619):644-7 - PMID: 12690206 - DOI: 10.1126/science.1083614

daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway.

Li W, Kennedy SG, Ruvkun G
Genes Dev. 2003;17(7):844-58 - PMID: 12654727 - PMCID: PMC196030 - DOI: 10.1101/gad.1066503

A uniform system for microRNA annotation.

Ambros V, Bartel B, Bartel DP, Burge CB, Carrington JC, Chen X, Dreyfuss G, Eddy SR, Griffiths-Jones S, Marshall M, Matzke M, Ruvkun G, Tuschl T
RNA. 2003;9(3):277-9 - PMID: 12592000 - PMCID: PMC1370393

Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes.

Ashrafi K, Chang FY, Watts JL, Fraser AG, Kamath RS, Ahringer J, Ruvkun G
Nature. 2003;421(6920):268-72 - PMID: 12529643 - DOI: 10.1038/nature01279

A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity.

Lee SS, Lee RY, Fraser AG, Kamath RS, Ahringer J, Ruvkun G
Nat Genet. 2002;33(1):40-8 - PMID: 12447374 - DOI: 10.1038/ng1056

Insulin receptor substrate and p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway.

Wolkow CA, Muñoz MJ, Riddle DL, Ruvkun G
J Biol Chem. 2002;277(51):49591-7 - PMID: 12393910 - DOI: 10.1074/jbc.M207866200

Control of developmental timing by micrornas and their targets.

Pasquinelli AE, Ruvkun G
Annu Rev Cell Dev Biol. 2002;18:495-513 - PMID: 12142272 - DOI: 10.1146/annurev.cellbio.18.012502.105832

The C. elegans POU-domain transcription factor UNC-86 regulates the tph-1 tryptophan hydroxylase gene and neurite outgrowth in specific serotonergic neurons.

Sze JY, Zhang S, Li J, Ruvkun G
Development. 2002;129(16):3901-11 - PMID: 12135927

Longevity: don't hold your breath.

Lee SS, Ruvkun G
Nature. 2002;418(6895):287-8 - PMID: 12124610 - DOI: 10.1038/418287a

Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway.

Lee RY, Hench J, Ruvkun G
Curr Biol. 2001;11(24):1950-7 - PMID: 11747821

The genetics of aging.

Finch CE, Ruvkun G
Annu Rev Genomics Hum Genet. 2001;2:435-62 - PMID: 11701657 - DOI: 10.1146/annurev.genom.2.1.435

Molecular biology. Glimpses of a tiny RNA world.

Ruvkun G
Science. 2001;294(5543):797-9 - PMID: 11679654 - DOI: 10.1126/science.1066315

Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing.

Grishok A, Pasquinelli AE, Conte D, Li N, Parrish S, Ha I, Baillie DL, Fire A, Ruvkun G, Mello CC
Cell. 2001;106(1):23-34 - PMID: 11461699

Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family.

Pierce SB, Costa M, Wisotzkey R, Devadhar S, Homburger SA, Buchman AR, Ferguson KC, Heller J, Platt DM, Pasquinelli AA, Liu LX, Doberstein SK, Ruvkun G
Genes Dev. 2001;15(6):672-86 - PMID: 11274053 - PMCID: PMC312654 - DOI: 10.1101/gad.867301

Graded expression of ceh-14 reporters in the hypodermis is induced by a gonadal signal.

Kagoshima H, Sommer R, Reinhart BJ, Cassata G, Ruvkun G, Bürglin TR
Dev Genes Evol. 2000;210(11):564-9 - PMID: 11180807 - DOI: 10.1007/s004270050347

Regulation of ectodermal and excretory function by the C. elegans POU homeobox gene ceh-6.

Bürglin TR, Ruvkun G
Development. 2001;128(5):779-90 - PMID: 11171402

Isoform-specific mutations in the Caenorhabditis elegans heterochronic gene lin-14 affect stage-specific patterning.

Reinhart BJ, Ruvkun G
Genetics. 2001;157(1):199-209 - PMID: 11139502 - PMCID: PMC1461488

Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways.

Cahill CM, Tzivion G, Nasrin N, Ogg S, Dore J, Ruvkun G, Alexander-Bridges M
J Biol Chem. 2000;276(16):13402-10 - PMID: 11124266 - DOI: 10.1074/jbc.M010042200

Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA.

Pasquinelli AE, Reinhart BJ, Slack F, Martindale MQ, Kuroda MI, Maller B, Hayward DC, Ball EE, Degnan B, Müller P, Spring J, Srinivasan A, Fishman M, Finnerty J, Corbo J, Levine M, Leahy P, Davidson E, Ruvkun G
Nature. 2000;408(6808):86-9 - PMID: 11081512 - DOI: 10.1038/35040556

Regulation of C. elegans life-span by insulinlike signaling in the nervous system.

Wolkow CA, Kimura KD, Lee MS, Ruvkun G
Science. 2000;290(5489):147-50 - PMID: 11021802

DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells.

Nasrin N, Ogg S, Cahill CM, Biggs W, Nui S, Dore J, Calvo D, Shi Y, Ruvkun G, Alexander-Bridges MC
Proc Natl Acad Sci U S A. 2000;97(19):10412-7 - PMID: 10973497 - PMCID: PMC27038 - DOI: 10.1073/pnas.190326997

The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor.

Slack FJ, Basson M, Liu Z, Ambros V, Horvitz HR, Ruvkun G
Mol Cell. 2000;5(4):659-69 - PMID: 10882102

The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans.

Reinhart BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC, Rougvie AE, Horvitz HR, Ruvkun G
Nature. 2000;403(6772):901-6 - PMID: 10706289 - DOI: 10.1038/35002607

Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant.

Sze JY, Victor M, Loer C, Shi Y, Ruvkun G
Nature. 2000;403(6769):560-4 - PMID: 10676966 - DOI: 10.1038/35000609

A common muscarinic pathway for diapause recovery in the distantly related nematode species Caenorhabditis elegans and Ancylostoma caninum.

Tissenbaum HA, Hawdon J, Perregaux M, Hotez P, Guarente L, Ruvkun G
Proc Natl Acad Sci U S A. 2000;97(1):460-5 - PMID: 10618440 - PMCID: PMC26685

Themes from a NASA workshop on gene regulatory processes in development and evolution.

Davidson EH, Ruvkun G
J Exp Zool. 1999;285(2):104-15 - PMID: 10440721

Alternative olfactory neuron fates are specified by the LIM homeobox gene lim-4.

Sagasti A, Hobert O, Troemel ER, Ruvkun G, Bargmann CI
Genes Dev. 1999;13(14):1794-806 - PMID: 10421632 - PMCID: PMC316880

A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans.

Paradis S, Ailion M, Toker A, Thomas JH, Ruvkun G
Genes Dev. 1999;13(11):1438-52 - PMID: 10364160 - PMCID: PMC316759

Pax genes in Caenorhabditis elegans: a new twist.

Hobert O, Ruvkun G
Trends Genet. 1999;15(6):214-6 - PMID: 10354580

The Caenorhabditis elegans lim-6 LIM homeobox gene regulates neurite outgrowth and function of particular GABAergic neurons.

Hobert O, Tessmar K, Ruvkun G
Development. 1999;126(7):1547-62 - PMID: 10068647

A common theme for LIM homeobox gene function across phylogeny?

Hobert O, Ruvkun G
Biol Bull. 1998;195(3):377-80 - PMID: 9924780 - DOI: 10.2307/1543153

Heterochronic genes in development and evolution.

Slack F, Ruvkun G
Biol Bull. 1998;195(3):375-6 - PMID: 9924779 - DOI: 10.2307/1543152

The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway.

Ogg S, Ruvkun G
Mol Cell. 1998;2(6):887-93 - PMID: 9885576

A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans.

Hobert O, Moerman DG, Clark KA, Beckerle MC, Ruvkun G
J Cell Biol. 1999;144(1):45-57 - PMID: 9885243 - PMCID: PMC2148118

A novel repeat domain that is often associated with RING finger and B-box motifs.

Slack FJ, Ruvkun G
Trends Biochem Sci. 1998;23(12):474-5 - PMID: 9868369

The taxonomy of developmental control in Caenorhabditis elegans.

Ruvkun G, Hobert O
Science. 1998;282(5396):2033-41 - PMID: 9851920

Aging, life span, and senescence.

Guarente L, Ruvkun G, Amasino R
Proc Natl Acad Sci U S A. 1998;95(19):11034-6 - PMID: 9736682 - PMCID: PMC33892

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor.

Paradis S, Ruvkun G
Genes Dev. 1998;12(16):2488-98 - PMID: 9716402 - PMCID: PMC317081

Control of neural development and function in a thermoregulatory network by the LIM homeobox gene lin-11.

Hobert O, D'Alberti T, Liu Y, Ruvkun G
J Neurosci. 1998;18(6):2084-96 - PMID: 9482795

An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans.

Tissenbaum HA, Ruvkun G
Genetics. 1998;148(2):703-17 - PMID: 9504918 - PMCID: PMC1459840

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans.

Ogg S, Paradis S, Gottlieb S, Patterson GI, Lee L, Tissenbaum HA, Ruvkun G
Nature. 1997;389(6654):994-9 - PMID: 9353126 - DOI: 10.1038/40194

The DAF-3 Smad protein antagonizes TGF-beta-related receptor signaling in the Caenorhabditis elegans dauer pathway.

Patterson GI, Koweek A, Wong A, Liu Y, Ruvkun G
Genes Dev. 1997;11(20):2679-90 - PMID: 9334330 - PMCID: PMC316611

daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans.

Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G
Science. 1997;277(5328):942-6 - PMID: 9252323

Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 LIM homeobox gene.

Hobert O, Mori I, Yamashita Y, Honda H, Ohshima Y, Liu Y, Ruvkun G
Neuron. 1997;19(2):345-57 - PMID: 9292724

The Caenorhabditis elegans orphan nuclear hormone receptor gene nhr-2 functions in early embryonic development.

Sluder AE, Lindblom T, Ruvkun G
Dev Biol. 1997;184(2):303-19 - PMID: 9133437 - DOI: 10.1006/dbio.1997.8544

VP16-activation of the C. elegans neural specification transcription factor UNC-86 suppresses mutations in downstream genes and causes defects in neural migration and axon outgrowth.

Sze JY, Liu Y, Ruvkun G
Development. 1997;124(6):1159-68 - PMID: 9102303

Temporal pattern formation by heterochronic genes.

Slack F, Ruvkun G
Annu Rev Genet. 1998;31:611-34 - PMID: 9442909 - DOI: 10.1146/annurev.genet.31.1.611

A bulged lin-4/lin-14 RNA duplex is sufficient for Caenorhabditis elegans lin-14 temporal gradient formation.

Ha I, Wightman B, Ruvkun G
Genes Dev. 1996;10(23):3041-50 - PMID: 8957004

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans.

Morris JZ, Tissenbaum HA, Ruvkun G
Nature. 1996;382(6591):536-9 - PMID: 8700226 - DOI: 10.1038/382536a0

The Caenorhabditis elegans behavioral gene unc-24 encodes a novel bipartite protein similar to both erythrocyte band 7.2 (stomatin) and nonspecific lipid transfer protein.

Barnes TM, Jin Y, Horvitz HR, Ruvkun G, Hekimi S
J Neurochem. 1996;67(1):46-57 - PMID: 8667025

Lineage-specific regulators couple cell lineage asymmetry to the transcription of the Caenorhabditis elegans POU gene unc-86 during neurogenesis.

Baumeister R, Liu Y, Ruvkun G
Genes Dev. 1996;10(11):1395-410 - PMID: 8647436

Targeted mutations in the Caenorhabditis elegans POU homeo box gene ceh-18 cause defects in oocyte cell cycle arrest, gonad migration, and epidermal differentiation.

Greenstein D, Hird S, Plasterk RH, Andachi Y, Kohara Y, Wang B, Finney M, Ruvkun G
Genes Dev. 1994;8(16):1935-48 - PMID: 7958868

daf-2, daf-16 and daf-23: genetically interacting genes controlling Dauer formation in Caenorhabditis elegans.

Gottlieb S, Ruvkun G
Genetics. 1994;137(1):107-20 - PMID: 8056303 - PMCID: PMC1205929

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans.

Wightman B, Ha I, Ruvkun G
Cell. 1993;75(5):855-62 - PMID: 8252622

The Caenorhabditis elegans homeobox gene cluster.

Bürglin TR, Ruvkun G
Curr Opin Genet Dev. 1993;3(4):615-20 - PMID: 7902148

Cell signalling. A molecular growth industry.

Ruvkun G
Nature. 1993;360(6406):711-2 - PMID: 1334532 - DOI: 10.1038/360711a0

Regulation of the mec-3 gene by the C.elegans homeoproteins UNC-86 and MEC-3.

Xue D, Finney M, Ruvkun G, Chalfie M
EMBO J. 1992;11(13):4969-79 - PMID: 1361171 - PMCID: PMC556975

New motif in PBX genes.

Bürglin TR, Ruvkun G
Nat Genet. 1992;1(5):319-20 - PMID: 1363814 - DOI: 10.1038/ng0892-319

C. elegans unc-4 gene encodes a homeodomain protein that determines the pattern of synaptic input to specific motor neurons.

Miller DM, Shen MM, Shamu CE, Bürglin TR, Ruvkun G, Dubois ML, Ghee M, Wilson L
Nature. 1992;355(6363):841-5 - PMID: 1347150 - DOI: 10.1038/355841a0

Temporal regulation of lin-14 by the antagonistic action of two other heterochronic genes, lin-4 and lin-28.

Arasu P, Wightman B, Ruvkun G
Genes Dev. 1991;5(10):1825-33 - PMID: 1916265

Negative regulatory sequences in the lin-14 3'-untranslated region are necessary to generate a temporal switch during Caenorhabditis elegans development.

Wightman B, Bürglin TR, Gatto J, Arasu P, Ruvkun G
Genes Dev. 1991;5(10):1813-24 - PMID: 1916264

Nematode homeobox cluster.

Bürglin TR, Ruvkun G, Coulson A, Hawkins NC, McGhee JD, Schaller D, Wittmann C, Müller F, Waterston RH
Nature. 1991;351(6329):703 - PMID: 1676487 - DOI: 10.1038/351703a0

Regulation of transcription and cell identity by POU domain proteins.

Ruvkun G, Finney M
Cell. 1991;64(3):475-8 - PMID: 1991317

Dominant gain-of-function mutations that lead to misregulation of the C. elegans heterochronic gene lin-14, and the evolutionary implications of dominant mutations in pattern-formation genes.

Ruvkun G, Wightman B, Bürglin T, Arasu P
Dev Suppl. 1992;1:47-54 - PMID: 1742500

The unc-86 gene product couples cell lineage and cell identity in C. elegans.

Finney M, Ruvkun G
Cell. 1990;63(5):895-905 - PMID: 2257628

Detection of mutations and DNA polymorphisms using whole genome Southern Cross hybridization.

Ruvkun G, Gilbert W, Horvitz HR
Nucleic Acids Res. 1990;18(4):809-15 - PMID: 2315039 - PMCID: PMC330331

Caenorhabditis elegans has scores of homoeobox-containing genes.

Bürglin TR, Finney M, Coulson A, Ruvkun G
Nature. 1989;341(6239):239-43 - PMID: 2571091 - DOI: 10.1038/341239a0

The Caenorhabditis elegans heterochronic gene lin-14 encodes a nuclear protein that forms a temporal developmental switch.

Ruvkun G, Giusto J
Nature. 1989;338(6213):313-9 - PMID: 2922060 - DOI: 10.1038/338313a0

Molecular genetics of the Caenorhabditis elegans heterochronic gene lin-14.

Ruvkun G, Ambros V, Coulson A, Waterston R, Sulston J, Horvitz HR
Genetics. 1989;121(3):501-16 - PMID: 2565854 - PMCID: PMC1203636

The C. elegans cell lineage and differentiation gene unc-86 encodes a protein with a homeodomain and extended similarity to transcription factors.

Finney M, Ruvkun G, Horvitz HR
Cell. 1988;55(5):757-69 - PMID: 2903797

The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products.

Herr W, Sturm RA, Clerc RG, Corcoran LM, Baltimore D, Sharp PA, Ingraham HA, Rosenfeld MG, Finney M, Ruvkun G
Genes Dev. 1988;2(12A):1513-6 - PMID: 3215510

Specific protection of nucleotides in the lac operator from DMS methylation and DNase I nicking by crude bacterial cell extracts.

Ruvkun GB, Sundaresan V, Ausubel FM
Gene. 1982;18(3):247-55 - PMID: 6290328

Directed transposon Tn5 mutagenesis and complementation analysis of Rhizobium meliloti symbiotic nitrogen fixation genes.

Ruvkun GB, Sundaresan V, Ausubel FM
Cell. 1982;29(2):551-9 - PMID: 6288262

ISRm1: A Rhizobium meliloti insertion sequence that transposes preferentially into nitrogen fixation genes.

Ruvkun GB, Long SR, Meade HM, van den Bos RC, Ausubel FM
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Physical and genetic characterization of symbiotic and auxotrophic mutants of Rhizobium meliloti induced by transposon Tn5 mutagenesis.

Meade HM, Long SR, Ruvkun GB, Brown SE, Ausubel FM
J Bacteriol. 1982;149(1):114-22 - PMID: 6274841 - PMCID: PMC216598

A general method for site-directed mutagenesis in prokaryotes.

Ruvkun GB, Ausubel FM
Nature. 1981;289(5793):85-8 - PMID: 6256652

Interspecies homology of nitrogenase genes.

Ruvkun GB, Ausubel FM
Proc Natl Acad Sci U S A. 1980;77(1):191-5 - PMID: 6987649 - PMCID: PMC348234

Analysis of high-throughput sequencing and annotation strategies for phage genomes.

Henn MR, Sullivan MB, Stange-Thomann N, Osburne MS, Berlin AM, Kelly L, Yandava C, Kodira C, Zeng Q, Weiand M, Sparrow T, Saif S, Giannoukos G, Young SK, Nusbaum C, Birren BW, Chisholm SW
PLoS One. 2010;5(2):e9083 - PMID: 20140207 - PMCID: PMC2816706 - DOI: 10.1371/journal.pone.0009083

cDNA sequences for transcription factors and signaling proteins of the hemichordate Saccoglossus kowalevskii: efficacy of the expressed sequence tag (EST) approach for evolutionary and developmental studies of a new organism.

Freeman RM, Wu M, Cordonnier-Pratt MM, Pratt LH, Gruber CE, Smith M, Lander ES, Stange-Thomann N, Lowe CJ, Gerhart J, Kirschner M
Biol Bull. 2008;214(3):284-302 - PMID: 18574105 - DOI: 10.2307/25470670

Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergence.

Neafsey DE, Schaffner SF, Volkman SK, Park D, Montgomery P, Milner DA, Lukens A, Rosen D, Daniels R, Houde N, Cortese JF, Tyndall E, Gates C, Stange-Thomann N, Sarr O, Ndiaye D, Ndir O, Mboup S, Ferreira MU, Moraes Sdo L, Dash AP, Chitnis CE, Wiegand RC, Hartl DL, Birren BW, Lander ES, Sabeti PC, Wirth DF
Genome Biol. 2008;9(12):R171 - PMID: 19077304 - PMCID: PMC2646275 - DOI: 10.1186/gb-2008-9-12-r171

A genome-wide map of diversity in Plasmodium falciparum.

Volkman SK, Sabeti PC, DeCaprio D, Neafsey DE, Schaffner SF, Milner DA, Daily JP, Sarr O, Ndiaye D, Ndir O, Mboup S, Duraisingh MT, Lukens A, Derr A, Stange-Thomann N, Waggoner S, Onofrio R, Ziaugra L, Mauceli E, Gnerre S, Jaffe DB, Zainoun J, Wiegand RC, Birren BW, Hartl DL, Galagan JE, Lander ES, Wirth DF
Nat Genet. 2006;39(1):113-9 - PMID: 17159979 - DOI: 10.1038/ng1930

Genome sequence, comparative analysis and haplotype structure of the domestic dog.

Lindblad-Toh K, Wade CM, Mikkelsen TS, Karlsson EK, Jaffe DB, Kamal M, Clamp M, Chang JL, Kulbokas EJ, Zody MC, Mauceli E, Xie X, Breen M, Wayne RK, Ostrander EA, Ponting CP, Galibert F, Smith DR, DeJong PJ, Kirkness E, Alvarez P, Biagi T, Brockman W, Butler J, Chin CW, Cook A, Cuff J, Daly MJ, DeCaprio D, Gnerre S, Grabherr M, Kellis M, Kleber M, Bardeleben C, Goodstadt L, Heger A, Hitte C, Kim L, Koepfli KP, Parker HG, Pollinger JP, Searle SM, Sutter NB, Thomas R, Webber C, Baldwin J, Abeb ...
Nature. 2005;438(7069):803-19 - PMID: 16341006 - DOI: 10.1038/nature04338

Assembly of polymorphic genomes: algorithms and application to Ciona savignyi.

Vinson JP, Jaffe DB, O'Neill K, Karlsson EK, Stange-Thomann N, Anderson S, Mesirov JP, Satoh N, Satou Y, Nusbaum C, Birren B, Galagan JE, Lander ES
Genome Res. 2005;15(8):1127-35 - PMID: 16077012 - PMCID: PMC1182225 - DOI: 10.1101/gr.3722605

Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype.

Jaillon O, Aury JM, Brunet F, Petit JL, Stange-Thomann N, Mauceli E, Bouneau L, Fischer C, Ozouf-Costaz C, Bernot A, Nicaud S, Jaffe D, Fisher S, Lutfalla G, Dossat C, Segurens B, Dasilva C, Salanoubat M, Levy M, Boudet N, Castellano S, Anthouard V, Jubin C, Castelli V, Katinka M, Vacherie B, Biémont C, Skalli Z, Cattolico L, Poulain J, De Berardinis V, Cruaud C, Duprat S, Brottier P, Coutanceau JP, Gouzy J, Parra G, Lardier G, Chapple C, McKernan KJ, McEwan P, Bosak S, Kellis M, Volff JN, G ...
Nature. 2004;431(7011):946-57 - PMID: 15496914 - DOI: 10.1038/nature03025

The complete genome and proteome of Mycoplasma mobile.

Jaffe JD, Stange-Thomann N, Smith C, DeCaprio D, Fisher S, Butler J, Calvo S, Elkins T, FitzGerald MG, Hafez N, Kodira CD, Major J, Wang S, Wilkinson J, Nicol R, Nusbaum C, Birren B, Berg HC, Church GM
Genome Res. 2004;14(8):1447-61 - PMID: 15289470 - PMCID: PMC509254 - DOI: 10.1101/gr.2674004

Comparative genomic analysis reveals independent expansion of a lineage-specific gene family in vertebrates: the class II cytokine receptors and their ligands in mammals and fish.

Lutfalla G, Roest Crollius H, Stange-Thomann N, Jaillon O, Mogensen K, Monneron D
BMC Genomics. 2003;4(1):29 - PMID: 12869211 - PMCID: PMC179897 - DOI: 10.1186/1471-2164-4-29

Anteroposterior patterning in hemichordates and the origins of the chordate nervous system.

Lowe CJ, Wu M, Salic A, Evans L, Lander E, Stange-Thomann N, Gruber CE, Gerhart J, Kirschner M
Cell. 2003;113(7):853-65 - PMID: 12837244

The genome sequence of the filamentous fungus Neurospora crassa.

Galagan JE, Calvo SE, Borkovich KA, Selker EU, Read ND, Jaffe D, FitzHugh W, Ma LJ, Smirnov S, Purcell S, Rehman B, Elkins T, Engels R, Wang S, Nielsen CB, Butler J, Endrizzi M, Qui D, Ianakiev P, Bell-Pedersen D, Nelson MA, Werner-Washburne M, Selitrennikoff CP, Kinsey JA, Braun EL, Zelter A, Schulte U, Kothe GO, Jedd G, Mewes W, Staben C, Marcotte E, Greenberg D, Roy A, Foley K, Naylor J, Stange-Thomann N, Barrett R, Gnerre S, Kamal M, Kamvysselis M, Mauceli E, Bielke C, Rudd S, Frishman D ...
Nature. 2003;422(6934):859-68 - PMID: 12712197 - DOI: 10.1038/nature01554

Pathogen discovery from human tissue by sequence-based computational subtraction.

Xu Y, Stange-Thomann N, Weber G, Bo R, Dodge S, David RG, Foley K, Beheshti J, Harris NL, Birren B, Lander ES, Meyerson M
Genomics. 2003;81(3):329-35 - PMID: 12659816

Initial sequencing and comparative analysis of the mouse genome.

Mouse Genome Sequencing Consortium, Waterston RH, Lindblad-Toh K, Birney E, Rogers J, Abril JF, Agarwal P, Agarwala R, Ainscough R, Alexandersson M, An P, Antonarakis SE, Attwood J, Baertsch R, Bailey J, Barlow K, Beck S, Berry E, Birren B, Bloom T, Bork P, Botcherby M, Bray N, Brent MR, Brown DG, Brown SD, Bult C, Burton J, Butler J, Campbell RD, Carninci P, Cawley S, Chiaromonte F, Chinwalla AT, Church DM, Clamp M, Clee C, Collins FS, Cook LL, Copley RR, Coulson A, Couronne O, Cuff J, Curw ...
Nature. 2002;420(6915):520-62 - PMID: 12466850 - DOI: 10.1038/nature01262

The genome of M. acetivorans reveals extensive metabolic and physiological diversity.

Galagan JE, Nusbaum C, Roy A, Endrizzi MG, Macdonald P, FitzHugh W, Calvo S, Engels R, Smirnov S, Atnoor D, Brown A, Allen N, Naylor J, Stange-Thomann N, DeArellano K, Johnson R, Linton L, McEwan P, McKernan K, Talamas J, Tirrell A, Ye W, Zimmer A, Barber RD, Cann I, Graham DE, Grahame DA, Guss AM, Hedderich R, Ingram-Smith C, Kuettner HC, Krzycki JA, Leigh JA, Li W, Liu J, Mukhopadhyay B, Reeve JN, Smith K, Springer TA, Umayam LA, White O, White RH, Conway de Macario E, Ferry JG, Jarrell KF ...
Genome Res. 2002;12(4):532-42 - PMID: 11932238 - PMCID: PMC187521 - DOI: 10.1101/gr.223902

A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms.

Sachidanandam R, Weissman D, Schmidt SC, Kakol JM, Stein LD, Marth G, Sherry S, Mullikin JC, Mortimore BJ, Willey DL, Hunt SE, Cole CG, Coggill PC, Rice CM, Ning Z, Rogers J, Bentley DR, Kwok PY, Mardis ER, Yeh RT, Schultz B, Cook L, Davenport R, Dante M, Fulton L, Hillier L, Waterston RH, McPherson JD, Gilman B, Schaffner S, Van Etten WJ, Reich D, Higgins J, Daly MJ, Blumenstiel B, Baldwin J, Stange-Thomann N, Zody MC, Linton L, Lander ES, Altshuler D,
Nature. 2001;409(6822):928-33 - PMID: 11237013 - DOI: 10.1038/35057149

Initial sequencing and analysis of the human genome.

Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, Devon K, Dewar K, Doyle M, FitzHugh W, Funke R, Gage D, Harris K, Heaford A, Howland J, Kann L, Lehoczky J, LeVine R, McEwan P, McKernan K, Meldrim J, Mesirov JP, Miranda C, Morris W, Naylor J, Raymond C, Rosetti M, Santos R, Sheridan A, Sougnez C, Stange-Thomann N, Stojanovic N, Subramanian A, Wyman D, Rogers J, Sulston J, Ainscough R, Beck S, Bentley D, Burton J, Clee C, Carter N, Coulson A, Deadman R, Deloukas P, Dunham A, Dun ...
Nature. 2001;409(6822):860-921 - PMID: 11237011 - DOI: 10.1038/35057062

Ancient adaptation of the active site of tryptophanyl-tRNA synthetase for tryptophan binding.

Praetorius-Ibba M, Stange-Thomann N, Kitabatake M, Ali K, Söll I, Carter CW, Ibba M, Söll D
Biochemistry. 2000;39(43):13136-43 - PMID: 11052665

A nuclear genetic lesion affecting Saccharomyces cerevisiae mitochondrial translation is complemented by a homologous Bacillus gene.

Kim SI, Stange-Thomann N, Martins O, Hong KW, Söll D, Fox TD
J Bacteriol. 1997;179(17):5625-7 - PMID: 9287027 - PMCID: PMC179443

Substrate selection by aminoacyl-tRNA synthetases.

Ibba M, Thomann HU, Hong KW, Sherman JM, Weygand-Durasevic I, Sever S, Stange-Thomann N, Praetorius M, Söll D
Nucleic Acids Symp Ser. 1996;(33):40-2 - PMID: 8643392

A point mutation in Euglena gracilis chloroplast tRNA(Glu) uncouples protein and chlorophyll biosynthesis.

Stange-Thomann N, Thomann HU, Lloyd AJ, Lyman H, Söll D
Proc Natl Acad Sci U S A. 1994;91(17):7947-51 - PMID: 8058739 - PMCID: PMC44521

Intron excision from tRNA precursors by plant splicing endonuclease requires unique features of the mature tRNA domain.

Stange N, Beier D, Beier H
Eur J Biochem. 1992;210(1):193-203 - PMID: 1332859

Expression of nuclear tRNA(Tyr) genes from Arabidopsis thaliana in HeLa cell and wheat germ extracts.

Stange N, Beier D, Beier H
Plant Mol Biol. 1991;16(5):865-75 - PMID: 1859869

Nuclear tRNA(Tyr) genes are highly amplified at a single chromosomal site in the genome of Arabidopsis thaliana.

Beier D, Stange N, Gross HJ, Beier H
Mol Gen Genet. 1991;225(1):72-80 - PMID: 2000093

Wheat germ splicing endonuclease is highly specific for plant pre-tRNAs.

Stange N, Gross HJ, Beier H
EMBO J. 1988;7(12):3823-8 - PMID: 3208752 - PMCID: PMC454960

A cell-free plant extract for accurate pre-tRNA processing, splicing and modification.

Stange N, Beier H
EMBO J. 1987;6(9):2811-8 - PMID: 3678205 - PMCID: PMC553707

A nuclear Nicotiana DNA sequence homologous to the 5' half of tRNATyr may have derived from reverse transcription of a pre-tRNA splicing intermediate.

Stange N, Gross HJ, Beier H
Nucleic Acids Res. 1987;15(13):5477 - PMID: 3648681 - PMCID: PMC305973

A human and a plant intron-containing tRNATyr gene are both transcribed in a HeLa cell extract but spliced along different pathways.

van Tol H, Stange N, Gross HJ, Beier H
EMBO J. 1987;6(1):35-41 - PMID: 3502708 - PMCID: PMC553353

A gene for the major cytoplasmic tRNATyr from Nicotiana rustica contains a 13 nucleotides long intron.

Stange N, Beier H
Nucleic Acids Res. 1986;14(21):8691 - PMID: 3641192 - PMCID: PMC311891

Evolution of genes and genomes on the Drosophila phylogeny.

Drosophila 12 Genomes Consortium, Clark AG, Eisen MB, Smith DR, Bergman CM, Oliver B, Markow TA, Kaufman TC, Kellis M, Gelbart W, Iyer VN, Pollard DA, Sackton TB, Larracuente AM, Singh ND, Abad JP, Abt DN, Adryan B, Aguade M, Akashi H, Anderson WW, Aquadro CF, Ardell DH, Arguello R, Artieri CG, Barbash DA, Barker D, Barsanti P, Batterham P, Batzoglou S, Begun D, Bhutkar A, Blanco E, Bosak SA, Bradley RK, Brand AD, Brent MR, Brooks AN, Brown RH, Butlin RK, Caggese C, Calvi BR, Bernardo de Car ...
Nature. 2007;450(7167):203-18 - PMID: 17994087 - DOI: 10.1038/nature06341

A high-resolution map of human evolutionary constraint using 29 mammals.

Lindblad-Toh K, Garber M, Zuk O, Lin MF, Parker BJ, Washietl S, Kheradpour P, Ernst J, Jordan G, Mauceli E, Ward LD, Lowe CB, Holloway AK, Clamp M, Gnerre S, Alföldi J, Beal K, Chang J, Clawson H, Cuff J, Di Palma F, Fitzgerald S, Flicek P, Guttman M, Hubisz MJ, Jaffe DB, Jungreis I, Kent WJ, Kostka D, Lara M, Martins AL, Massingham T, Moltke I, Raney BJ, Rasmussen MD, Robinson J, Stark A, Vilella AJ, Wen J, Xie X, Zody MC; Broad Institute Sequencing Platform and Whole Genome Assembly Team, ...
Nature. 2011;478(7370):476-82 - PMID: 21993624 - PMCID: PMC3207357 - DOI: 10.1038/nature10530

Gram-Negative Bacterial Infection in Thigh Abscess Can Migrate to Distant Burn Depending on Burn Depth.

Hamrahi V, Hamblin MR, Jung W, Benjamin JB, Paul KW, Fischman AJ, Tompkins RG, Carter EA
Interdiscip Perspect Infect Dis. 2012;2012:567140 - PMID: 22899912 - PMCID: PMC3412104 - DOI: 10.1155/2012/567140

Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes.

Quintin J, Saeed S, Martens JH, Giamarellos-Bourboulis EJ, Ifrim DC, Logie C, Jacobs L, Jansen T, Kullberg BJ, Wijmenga C, Joosten LA, Xavier RJ, van der Meer JW, Stunnenberg HG, Netea MG
Cell Host Microbe. 2012;12(2):223-32 - PMID: 22901542 - PMCID: PMC3864037 - DOI: 10.1016/j.chom.2012.06.006

Genome-Wide Identification of Pseudomonas aeruginosa Virulence-Related Genes Using a Caenorhabditis elegans Infection Model.

Feinbaum RL, Urbach JM, Liberati NT, Djonovic S, Adonizio A, Carvunis AR, Ausubel FM
PLoS Pathog. 2012;8(7):e1002813 - PMID: 22911607 - PMCID: PMC3406104 - DOI: 10.1371/journal.ppat.1002813

p40phox Expression Regulates Neutrophil Recruitment and Function during the Resolution Phase of Intestinal Inflammation.

Conway KL, Goel G, Sokol H, Manocha M, Mizoguchi E, Terhorst C, Bhan AK, Gardet A, Xavier RJ
J Immunol. 2012;189(7):3631-40 - PMID: 22914050 - PMCID: PMC3780969 - DOI: 10.4049/jimmunol.1103746

Complexity in Differential Peptide-Receptor Signaling: Response to Segonzac et al. and Mueller et al. Commentaries.

Lee H, Khatri A, Plotnikov JM, Zhang XC, Sheen J
Plant Cell. 2012;24(8):3177-85 - PMID: 22923676 - PMCID: PMC3462623 - DOI: 10.1105/tpc.112.099259

FLS2-Mediated Responses to Ax21-Derived Peptides: Response to the Mueller et al. Commentary.

Danna CH, Zhang XC, Khatri A, Bent AF, Ronald PC, Ausubel FM
Plant Cell. 2012;24(8):3174-6 - PMID: 22923675 - PMCID: PMC3462622 - DOI: 10.1105/tpc.112.099275

Measuring the cost of care for children with acute burn injury.

Carey K, Kazis LE, Lee AF, Liang MH, Li NC, Hinson MI, Lydon MK, Bauk H, Shapiro GD, Tompkins RG,
J Trauma Acute Care Surg. 2012;73(3 Suppl 2):S229-33 - PMID: 22929551 - DOI: 10.1097/TA.0b013e318265c88a

Impact of hand burns on health-related quality of life in children younger than 5 years.

Palmieri TL, Nelson-Mooney K, Kagan RJ, Stubbs TK, Meyer WJ, Herndon DN, Hinson MI, Lee AF, Li NC, Kazis LE, Tompkins RG,
J Trauma Acute Care Surg. 2012;73(3 Suppl 2):S197-204 - PMID: 22929547 - DOI: 10.1097/TA.0b013e318265c7ff

The American Burn Association/Shriners Hospitals for Children Burn Outcomes Program: A progress report at 15 years.

Tompkins RG, Liang MH, Lee AF, Kazis LE,
J Trauma Acute Care Surg. 2012;73(3 Suppl 2):S173-8 - PMID: 22929544 - DOI: 10.1097/TA.0b013e318265c53e

Type I macrophage scavenger receptor contains alpha-helical and collagen-like coiled coils.

Kodama T, Freeman M, Rohrer L, Zabrecky J, Matsudaira P, Krieger M
Nature. 1990;343(6258):531-5 - PMID: 2300204 - DOI: 10.1038/343531a0

Coiled-coil fibrous domains mediate ligand binding by macrophage scavenger receptor type II.

Rohrer L, Freeman M, Kodama T, Penman M, Krieger M
Nature. 1990;343(6258):570-2 - PMID: 2300208 - DOI: 10.1038/343570a0

An ancient, highly conserved family of cysteine-rich protein domains revealed by cloning type I and type II murine macrophage scavenger receptors.

Freeman M, Ashkenas J, Rees DJ, Kingsley DM, Copeland NG, Jenkins NA, Krieger M
Proc Natl Acad Sci U S A. 1990;87(22):8810-4 - PMID: 1978939 - PMCID: PMC55049

Expression of type I and type II bovine scavenger receptors in Chinese hamster ovary cells: lipid droplet accumulation and nonreciprocal cross competition by acetylated and oxidized low density lipoprotein.

Freeman M, Ekkel Y, Rohrer L, Penman M, Freedman NJ, Chisolm GM, Krieger M
Proc Natl Acad Sci U S A. 1991;88(11):4931-5 - PMID: 2052575 - PMCID: PMC51781

A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide.

Jüppner H, Abou-Samra AB, Freeman M, Kong XF, Schipani E, Richards J, Kolakowski LF, Hock J, Potts JT, Kronenberg HM
Science. 1991;254(5034):1024-6 - PMID: 1658941

Characterization of cloned PTH/PTHrP receptors.

Segre GV, Abou-Samra AB, Jüppner H, Schipani E, Force T, Urena P, Freeman M, Kong XF, Kolakowski LF, Hock J
J Endocrinol Invest. 1993;15(9 Suppl 6):11-7 - PMID: 1338633

Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium.

Abou-Samra AB, Jüppner H, Force T, Freeman MW, Kong XF, Schipani E, Urena P, Richards J, Bonventre JV, Potts JT
Proc Natl Acad Sci U S A. 1992;89(7):2732-6 - PMID: 1313566 - PMCID: PMC48736

Structures and high and low affinity ligand binding properties of murine type I and type II macrophage scavenger receptors.

Ashkenas J, Penman M, Vasile E, Acton S, Freeman M, Krieger M
J Lipid Res. 1993;34(6):983-1000 - PMID: 8394868

Expression of the macrophage scavenger receptor, a multifunctional lipoprotein receptor, in microglia associated with senile plaques in Alzheimer's disease.

Christie RH, Freeman M, Hyman BT
Am J Pathol. 1996;148(2):399-403 - PMID: 8579103 - PMCID: PMC1861668

LBP, CD14, TLR4 and the murine innate immune response to a peritoneal Salmonella infection.

Bernheiden M, Heinrich JM, Minigo G, Schütt C, Stelter F, Freeman M, Golenbock D, Jack RS
J Endotoxin Res. 2001;7(6):447-50 - PMID: 11753215

Previous burn injury predisposes mice to lipopolysaccharide-induced changes in glucose metabolism.

Carter EA, Paul KW, Barrow SA, Fischman AJ, Tompkins RG
J Burn Care Res. 2012;33(5):683-9 - PMID: 22961012 - PMCID: PMC3441057 - DOI: 10.1097/BCR.0b013e31825d6a86

Purification of ATP-binding cassette transporter A1 and associated binding proteins reveals the importance of beta1-syntrophin in cholesterol efflux.

Okuhira K, Fitzgerald ML, Sarracino DA, Manning JJ, Bell SA, Goss JL, Freeman MW
J Biol Chem. 2005;280(47):39653-64 - PMID: 16192269 - DOI: 10.1074/jbc.M510187200

Nonparametric methods for microarray data based on exchangeability and borrowed power.

Lee ML, Whitmore GA, Björkbacka H, Freeman MW
J Biopharm Stat. 2005;15(5):783-97 - PMID: 16078385 - DOI: 10.1081/BIP-200067778

Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice.

Moore KJ, Kunjathoor VV, Koehn SL, Manning JJ, Tseng AA, Silver JM, McKee M, Freeman MW
J Clin Invest. 2005;115(8):2192-201 - PMID: 16075060 - PMCID: PMC1180534 - DOI: 10.1172/JCI24061

Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment.

Heller EA, Liu E, Tager AM, Sinha S, Roberts JD, Koehn SL, Libby P, Aikawa ER, Chen JQ, Huang P, Freeman MW, Moore KJ, Luster AD, Gerszten RE
Circulation. 2005;112(4):578-86 - PMID: 16043658 - DOI: 10.1161/CIRCULATIONAHA.105.545616

Atherosclerosis and innate immune signaling.

Laberge MA, Moore KJ, Freeman MW
Ann Med. 2005;37(2):130-40 - PMID: 16026120

Efficacy and safety of the coadministration of ezetimibe with fenofibrate in patients with mixed hyperlipidaemia.

Farnier M, Freeman MW, Macdonell G, Perevozskaya I, Davies MJ, Mitchel YB, Gumbiner B,
Eur Heart J. 2005;26(9):897-905 - PMID: 15781429 - DOI: 10.1093/eurheartj/ehi231

Distinct roles of pattern recognition receptors CD14 and Toll-like receptor 4 in acute lung injury.

Jeyaseelan S, Chu HW, Young SK, Freeman MW, Worthen GS
Infect Immun. 2005;73(3):1754-63 - PMID: 15731076 - PMCID: PMC1064978 - DOI: 10.1128/IAI.73.3.1754-1763.2005

Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis.

Ricci R, Sumara G, Sumara I, Rozenberg I, Kurrer M, Akhmedov A, Hersberger M, Eriksson U, Eberli FR, Becher B, Borén J, Chen M, Cybulsky MI, Moore KJ, Freeman MW, Wagner EF, Matter CM, Lüscher TF
Science. 2004;306(5701):1558-61 - PMID: 15567863 - DOI: 10.1126/science.1101909

Abca7 null mice retain normal macrophage phosphatidylcholine and cholesterol efflux activity despite alterations in adipose mass and serum cholesterol levels.

Kim WS, Fitzgerald ML, Kang K, Okuhira K, Bell SA, Manning JJ, Koehn SL, Lu N, Moore KJ, Freeman MW
J Biol Chem. 2004;280(5):3989-95 - PMID: 15550377 - DOI: 10.1074/jbc.M412602200

The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades.

Björkbacka H, Fitzgerald KA, Huet F, Li X, Gregory JA, Lee MA, Ordija CM, Dowley NE, Golenbock DT, Freeman MW
Physiol Genomics. 2004;19(3):319-30 - PMID: 15367722 - DOI: 10.1152/physiolgenomics.00128.2004

ATP-binding cassette transporter A1 contains a novel C-terminal VFVNFA motif that is required for its cholesterol efflux and ApoA-I binding activities.

Fitzgerald ML, Okuhira K, Short GF, Manning JJ, Bell SA, Freeman MW
J Biol Chem. 2004;279(46):48477-85 - PMID: 15347662 - DOI: 10.1074/jbc.M409848200

Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways.

Björkbacka H, Kunjathoor VV, Moore KJ, Koehn S, Ordija CM, Lee MA, Means T, Halmen K, Luster AD, Golenbock DT, Freeman MW
Nat Med. 2004;10(4):416-21 - PMID: 15034566 - DOI: 10.1038/nm1008

Cross-linking and lipid efflux properties of apoA-I mutants suggest direct association between apoA-I helices and ABCA1.

Chroni A, Liu T, Fitzgerald ML, Freeman MW, Zannis VI
Biochemistry. 2004;43(7):2126-39 - PMID: 14967052 - DOI: 10.1021/bi035813p

ABCA1 and amphipathic apolipoproteins form high-affinity molecular complexes required for cholesterol efflux.

Fitzgerald ML, Morris AL, Chroni A, Mendez AJ, Zannis VI, Freeman MW
J Lipid Res. 2003;45(2):287-94 - PMID: 14617740 - DOI: 10.1194/jlr.M300355-JLR200

Activation of signaling pathways by putative scavenger receptor class A (SR-A) ligands requires CD14 but not SR-A.

Kim WS, Ordija CM, Freeman MW
Biochem Biophys Res Commun. 2003;310(2):542-9 - PMID: 14521944

CD36 mediates the innate host response to beta-amyloid.

El Khoury JB, Moore KJ, Means TK, Leung J, Terada K, Toft M, Freeman MW, Luster AD
J Exp Med. 2003;197(12):1657-66 - PMID: 12796468 - PMCID: PMC2193948 - DOI: 10.1084/jem.20021546

eLiXiRs for restraining inflammation.

Freeman MW, Moore KJ
Nat Med. 2003;9(2):168-9 - PMID: 12563335 - DOI: 10.1038/nm0203-168

Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages.

Kunjathoor VV, Febbraio M, Podrez EA, Moore KJ, Andersson L, Koehn S, Rhee JS, Silverstein R, Hoff HF, Freeman MW
J Biol Chem. 2002;277(51):49982-8 - PMID: 12376530 - DOI: 10.1074/jbc.M209649200

Neutrophil influx in response to a peritoneal infection with Salmonella is delayed in lipopolysaccharide-binding protein or CD14-deficient mice.

Yang KK, Dorner BG, Merkel U, Ryffel B, Schütt C, Golenbock D, Freeman MW, Jack RS
J Immunol. 2002;169(8):4475-80 - PMID: 12370383

Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways.

Henneke P, Takeuchi O, Malley R, Lien E, Ingalls RR, Freeman MW, Mayadas T, Nizet V, Akira S, Kasper DL, Golenbock DT
J Immunol. 2002;169(7):3970-7 - PMID: 12244198

A CD36-initiated signaling cascade mediates inflammatory effects of beta-amyloid.

Moore KJ, El Khoury J, Medeiros LA, Terada K, Geula C, Luster AD, Freeman MW
J Biol Chem. 2002;277(49):47373-9 - PMID: 12239221 - DOI: 10.1074/jbc.M208788200

Naturally occurring mutations in the largest extracellular loops of ABCA1 can disrupt its direct interaction with apolipoprotein A-I.

Fitzgerald ML, Morris AL, Rhee JS, Andersson LP, Mendez AJ, Freeman MW
J Biol Chem. 2002;277(36):33178-87 - PMID: 12084722 - DOI: 10.1074/jbc.M204996200

Nuclear hormone receptors and cholesterol trafficking: the orphans find a new home.

Fitzgerald ML, Moore KJ, Freeman MW
J Mol Med (Berl). 2002;80(5):271-81 - PMID: 12021839 - DOI: 10.1007/s00109-001-0318-y

C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway.

Rosen ED, Hsu CH, Wang X, Sakai S, Freeman MW, Gonzalez FJ, Spiegelman BM
Genes Dev. 2002;16(1):22-6 - PMID: 11782441 - PMCID: PMC155311 - DOI: 10.1101/gad.948702

Peroxisome proliferator-activated receptors in macrophage biology: friend or foe?

Moore KJ, Fitzgerald ML, Freeman MW
Curr Opin Lipidol. 2001;12(5):519-27 - PMID: 11561171

Evidence that dendritic cells infiltrate atherosclerotic lesions in apolipoprotein E-deficient mice.

Bobryshev YV, Taksir T, Lord RS, Freeman MW
Histol Histopathol. 2001;16(3):801-8 - PMID: 11510970 - DOI: 10.14670/HH-16.801

ATP-binding cassette transporter A1 contains an NH2-terminal signal anchor sequence that translocates the protein's first hydrophilic domain to the exoplasmic space.

Fitzgerald ML, Mendez AJ, Moore KJ, Andersson LP, Panjeton HA, Freeman MW
J Biol Chem. 2001;276(18):15137-45 - PMID: 11328826

Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus.

Kurt-Jones EA, Popova L, Kwinn L, Haynes LM, Jones LP, Tripp RA, Walsh EE, Freeman MW, Golenbock DT, Anderson LJ, Finberg RW
Nat Immunol. 2000;1(5):398-401 - PMID: 11062499 - DOI: 10.1038/80833

Manipulating intestinal cholesterol absorption and hepatic cholesterol and bile acid metabolism by activation of deorphanized nuclear receptors.

Rigotti A, Freeman MW
Gastroenterology. 2001;120(4):1054-5 - PMID: 11231965

The role of PPAR-gamma in macrophage differentiation and cholesterol uptake.

Moore KJ, Rosen ED, Fitzgerald ML, Randow F, Andersson LP, Altshuler D, Milstone DS, Mortensen RM, Spiegelman BM, Freeman MW
Nat Med. 2001;7(1):41-7 - PMID: 11135614 - DOI: 10.1038/83328

Effects of overexpression of the amino-terminal fragment of apolipoprotein B on apolipoprotein B and lipoprotein production.

Li Z, Kako Y, Pang L, Freeman MW, Glick JM, Wang X, Goldberg IJ
J Lipid Res. 2000;41(12):1912-20 - PMID: 11108724

Episomal segregation of the adenovirus enhancer sequence by conditional genome rearrangement abrogates late viral gene expression.

Wang X, Zeng W, Murakawa M, Freeman MW, Seed B
J Virol. 2000;74(23):11296-303 - PMID: 11070029 - PMCID: PMC113234

Divergent response to LPS and bacteria in CD14-deficient murine macrophages.

Moore KJ, Andersson LP, Ingalls RR, Monks BG, Li R, Arnaout MA, Golenbock DT, Freeman MW
J Immunol. 2000;165(8):4272-80 - PMID: 11035061

Cellular cholesterol efflux in heterozygotes for tangier disease is markedly reduced and correlates with high density lipoprotein cholesterol concentration and particle size.

Brousseau ME, Eberhart GP, Dupuis J, Asztalos BF, Goldkamp AL, Schaefer EJ, Freeman MW
J Lipid Res. 2000;41(7):1125-35 - PMID: 10884295

Novel mutations in the gene encoding ATP-binding cassette 1 in four tangier disease kindreds.

Brousseau ME, Schaefer EJ, Dupuis J, Eustace B, Van Eerdewegh P, Goldkamp AL, Thurston LM, FitzGerald MG, Yasek-McKenna D, O'Neill G, Eberhart GP, Weiffenbach B, Ordovas JM, Freeman MW, Brown RH, Gu JZ
J Lipid Res. 2000;41(3):433-41 - PMID: 10706591

Lipopolysaccharide induces scavenger receptor A expression in mouse macrophages: a divergent response relative to human THP-1 monocyte/macrophages.

Fitzgerald ML, Moore KJ, Freeman MW, Reed GL
J Immunol. 2000;164(5):2692-700 - PMID: 10679110

Stromelysin-1 (MMP-3) expression driven by a macrophage-specific promoter results in reduced viability in transgenic mice.

Fabunmi RP, Moore KJ, Libby P, Freeman MW
Atherosclerosis. 2000;148(2):375-86 - PMID: 10657574

Effluxed lipids: Tangier Island's latest export.

Freeman MW
Proc Natl Acad Sci U S A. 1999;96(20):10950-2 - PMID: 10500104 - PMCID: PMC34222

Leukotriene B4 receptor transgenic mice reveal novel protective roles for lipoxins and aspirin-triggered lipoxins in reperfusion.

Chiang N, Gronert K, Clish CB, O'Brien JA, Freeman MW, Serhan CN
J Clin Invest. 1999;104(3):309-16 - PMID: 10430612 - PMCID: PMC408424 - DOI: 10.1172/JCI7016

In vitro-differentiated embryonic stem cell macrophages: a model system for studying atherosclerosis-associated macrophage functions.

Moore KJ, Fabunmi RP, Andersson LP, Freeman MW
Arterioscler Thromb Vasc Biol. 1998;18(10):1647-54 - PMID: 9763539

Functional changes in scavenger receptor binding conformation are induced by charge mutants spanning the entire collagen domain.

Andersson L, Freeman MW
J Biol Chem. 1998;273(31):19592-601 - PMID: 9677385

Decreased cholesterol efflux from fibroblasts of a patient without Tangier disease, but with markedly reduced high density lipoprotein cholesterol levels.

Eberhart GP, Mendez AJ, Freeman MW
J Clin Endocrinol Metab. 1998;83(3):836-46 - PMID: 9506737 - DOI: 10.1210/jcem.83.3.4642

Scavenger receptors in atherosclerosis.

Freeman MW
Curr Opin Hematol. 1997;4(1):41-7 - PMID: 9050378

Structure of the murine macrophage scavenger receptor gene and evaluation of sequences that regulate expression in the macrophage cell line, P388D.

Aftring RP, Freeman MW
J Lipid Res. 1995;36(6):1305-14 - PMID: 7666008

Regulation of smooth muscle cell scavenger receptor expression in vivo by atherogenic diets and in vitro by cytokines.

Li H, Freeman MW, Libby P
J Clin Invest. 1995;95(1):122-33 - PMID: 7814605 - PMCID: PMC295387 - DOI: 10.1172/JCI117628

Of mice, men and cholesterol.

Aftring RP, Freeman MW
Hepatology. 1994;19(4):1054-6 - PMID: 8138246

Macrophage scavenger receptors.

Freeman MW
Curr Opin Lipidol. 1994;5(2):143-8 - PMID: 8044417

Surface expression of human CD14 in Chinese hamster ovary fibroblasts imparts macrophage-like responsiveness to bacterial endotoxin.

Golenbock DT, Liu Y, Millham FH, Freeman MW, Zoeller RA
J Biol Chem. 1993;268(29):22055-9 - PMID: 7691822

Postmenopausal hormone-replacement therapy.

Martin KA, Freeman MW
N Engl J Med. 1993;328(15):1115-7 - PMID: 8455670 - DOI: 10.1056/NEJM199304153281509

Ascorbic acid oxidation product(s) protect human low density lipoprotein against atherogenic modification. Anti- rather than prooxidant activity of vitamin C in the presence of transition metal ions.

Retsky KL, Freeman MW, Frei B
J Biol Chem. 1993;268(2):1304-9 - PMID: 8419332

Rabbit aortic smooth muscle cells express inducible macrophage scavenger receptor messenger RNA that is absent from endothelial cells.

Bickel PE, Freeman MW
J Clin Invest. 1992;90(4):1450-7 - PMID: 1401078 - PMCID: PMC443191 - DOI: 10.1172/JCI116012

Thymosin beta 4 is expressed in ROS 17/2.8 osteosarcoma cells in a regulated manner.

Atkinson MJ, Freeman MW, Kronenberg HM
Mol Endocrinol. 1990;4(1):69-74 - PMID: 2325669 - DOI: 10.1210/mend-4-1-69

Mutations in signal sequence cleavage domain of preproparathyroid hormone alter protein translocation, signal sequence cleavage, and membrane-binding properties.

Wiren KM, Ivashkiv L, Ma P, Freeman MW, Potts JT, Kronenberg HM
Mol Endocrinol. 1989;3(2):240-50 - PMID: 2710131 - DOI: 10.1210/mend-3-2-240

Central nervous system lesions in pediatric patients: Gd-DTPA-enhanced MR imaging.

Powers TA, Partain CL, Kessler RM, Freeman MW, Robertson RH, Wyatt SH, Whelan HT
Radiology. 1988;169(3):723-6 - PMID: 3055036 - DOI: 10.1148/radiology.169.3.3055036

Consequences of amino-terminal deletions of preproparathyroid hormone signal sequence.

Freeman MW, Wiren KM, Rapoport A, Lazar M, Potts JT, Kronenberg HM
Mol Endocrinol. 1987;1(9):628-38 - PMID: 3153480 - DOI: 10.1210/mend-1-9-628

Preproparathyroid hormone. A model for analyzing the secretory pathway.

Wiren KM, Freeman MW, Potts JT, Kronenberg HM
Ann N Y Acad Sci. 1987;493:43-9 - PMID: 3473968

Structure and expression of the human parathyroid hormone gene.

Kronenberg HM, Igarashi T, Freeman MW, Okazaki T, Brand SJ, Wiren KM, Potts JT
Recent Prog Horm Res. 1986;42:641-63 - PMID: 3526456

Nucleotide sequence of the human parathyroid hormone gene.

Vasicek TJ, McDevitt BE, Freeman MW, Fennick BJ, Hendy GN, Potts JT, Rich A, Kronenberg HM
Proc Natl Acad Sci U S A. 1983;80(8):2127-31 - PMID: 6220408 - PMCID: PMC393770

The effect of oxandrolone on low and high density lipoprotein profiles in retired breeder rats.

Freeman MW, Spring-Mills E, Jones AL
J Gerontol. 1980;35(1):31-8 - PMID: 7350219

Guidelines for the use and interpretation of assays for monitoring autophagy.

Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai ...
Autophagy. 2012;8(4):445-544 - PMID: 22966490 - PMCID: PMC3404883

Chemistry, molecular biology, and mode of action of parathyroid hormone.

Potts, JT Jr, Nussbaum S, Wiren K, Freeman M, Igarashi T, Okazaki T, Zajac J, Abou-Samra AB, Bringhurst FR, Segre G, HM Kronenberg
Proceedings of the First International Conference on New Actions of Parathyroid Hormone. Kobe, Japan. 1987;:ePub

Preproparathyroid hormone: a model for analyzing the secretory pathway.

Wiren KM, Freeman MW, Potts JT Jr, HM Kronenberg
Ann NY Acad Sci. 1987;493:43-49

Postmenopausal hormone-replacement therapy

Martin KA, and Freeman MW
New Engl J Med. 1993;328:1115-1117

Harvard Medical School Guide to Lowering your Cholesterol

MW Freeman and Christine Junge
2005;:ePub

Evaluation of OPEN Zinc Finger Nucleases for Direct Gene Targeting of the ROSA26 Locus in Mouse Embryos.

Hermann M, Maeder ML, Rector K, Ruiz J, Becher B, Bürki K, Khayter C, Aguzzi A, Joung JK, Buch T, Pelczar P
PLoS One. 2012;7(9):e41796 - PMID: 22970113 - PMCID: PMC3435328 - DOI: 10.1371/journal.pone.0041796

CDPKs in immune and stress signaling.

Boudsocq M, Sheen J
Trends Plant Sci. 2012;18(1):30-40 - PMID: 22974587 - PMCID: PMC3534830 - DOI: 10.1016/j.tplants.2012.08.008

What to do about high cholesterol

M Freeman, Consultant editor. PJ Skerret and SD Emond
President and Fellows of Harvard College. Harvard Health Publications. 1993;:ePub

What to do about high cholesterol

M Freeman, Consultant editor 2nd edition. PJ Skerret and SD Emond
President and Fellows of Harvard College. Harvard Health Publications. 2000;:ePub

The Treatment of Dyslipidemia: LDL Reduction and Beyond

MW Freeman
In Endocrinology Rounds. 2002;1, Issue 8:ePub

What to do about high cholesterol

M Freeman, Consultant editor 3rd edition Junge C, Skerret PJ, and Emond, SD.
President and Fellows of Harvard College. Harvard Health Publications. 2005;:ePub

What to do about high cholesterol

M Freeman, Consultant editor, 4th edition. Buckley, Rita
President and Fellows of Harvard College. Harvard Health Publications. 2009;:ePub

Preproparathyroid hormone: Use of mutants to study secretion. In: Cohn DV, Martin TJ, Meunier PJ, eds.

Kronenberg HM, Wiren KM, Freeman MW, JT Potts Jr
Calcium Regulation and Bone Metabolism: Basic and Clinical Aspects, Vol. 9. Amsterdam: Excerpta Medica. 1987;9:773-777

Risk factors in coronary artery disease and cardiac rehabilitation. In: Haber E, Eagle KA, Austen WG, eds

Freeman MW, Rigotti NA, and T. Force
The Practice of Cardiology. 1989;:563-614

Macrophage scavenger receptors

MW Freeman
Current Opinions in Lipidology . 1994;5:143-148

Of mice, men and cholesterol

Aftring RP and MW Freeman
Hepatology. 1994;19:1054-1056

Screening for hyperlipidemia. In: Goroll A, May L, Mulley A, eds

Haydock GS and MW Freeman
1995. 1995;Primary Care Medicine, 3rd Edit:72-75

Lipoprotein Metabolism and the Treatment of Lipid Disorders, Chapter 42. In: DeGroot LJ and JL Jameson, eds

MW Freeman
Endocrinology, 6th edition. 2010;:ePub

Approach to the patient with hypercholesterolemia. In: Goroll A, May L, Mulley A, eds

MW Freeman
Primary Care Medicine, 6th Edition. 2009;:ePub

Screening for hyperlipidemia. In: Goroll A and Mulley A, eds.

Haydock GS and MW Freeman
Primary Care Medicine, 6th Edition. 2009;:ePub

Targeting innate immunity for CV benefit

KJ Moore and MW Freeman
Drug Discovery Today: Therapeutic Strategies. 2008;5:15-23

Lipid Disorders and Coronary Heart Disease. In: Runge, MS and Patterson, W Eds.

MW Freeman
Molecular Medicine. 2006;:ePub

Scavenger receptors in atherosclerosis

MW Freeman and KJ Moore
Arterioscler Thromb Vasc Biol. 2006;8:1702-1711

Approach to the patient with hypercholesterolemia. In: Goroll A, May L, Mulley A, eds

MW Freeman
Primary Care Medicine, 5th Edition. 2005;:ePub

Tangier Disease and Neuropathy. In: Dyck, PJ and Thomas, PK, Eds

Gilmore O’Neill and MW Freeman
Peripheral Neuropathy 4th edition. 2005;:ePub

Statins, cholesterol, and the prevention of coronary heart disease

MW Freeman
FASEB J. 2006;20(2):200-201

Atherosclerosis and innate immunity signaling

Laberge MA, Moore KJ, and MW Freeman.
Annals of Medicine. 2005;37:130-140

Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes.

Kleinnijenhuis J, Quintin J, Preijers F, Joosten LA, Ifrim DC, Saeed S, Jacobs C, van Loenhout J, de Jong D, Stunnenberg HG, Xavier RJ, van der Meer JW, van Crevel R, Netea MG
Proc Natl Acad Sci U S A. 2012;109(43):17537-42 - PMID: 22988082 - PMCID: PMC3491454 - DOI: 10.1073/pnas.1202870109

Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment.

Morgan XC, Tickle TL, Sokol H, Gevers D, Devaney KL, Ward DV, Reyes JA, Shah SA, Leleiko N, Snapper SB, Bousvaros A, Korzenik J, Sands BE, Xavier RJ, Huttenhower C
Genome Biol. 2012;13(9):R79 - PMID: 23013615 - PMCID: PMC3506950 - DOI: 10.1186/gb-2012-13-9-r79

Safety and dosing of bevacizumab (avastin) for the treatment of recurrent respiratory papillomatosis.

Best SR, Friedman AD, Landau-Zemer T, Barbu AM, Burns JA, Freeman MW, Halvorsen YD, Hillman RE, Zeitels SM
Ann Otol Rhinol Laryngol. 2012;121(9):587-93 - PMID: 23012897 - DOI: 10.1177/000348941212100905

Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule.

Holler N, Zaru R, Micheau O, Thome M, Attinger A, Valitutti S, Bodmer JL, Schneider P, Seed B, Tschopp J
Nat Immunol. 2000;1(6):489-95 - PMID: 11101870 - DOI: 10.1038/82732

Episomal segregation of the adenovirus enhancer sequence by conditional genome rearrangement abrogates late viral gene expression.

Wang X, Zeng W, Murakawa M, Freeman MW, Seed B
J Virol. 2000;74(23):11296-303 - PMID: 11070029 - PMCID: PMC113234

Mechanisms of NSAID-induced gastrointestinal injury defined using mutant mice.

Beck PL, Xavier R, Lu N, Nanda NN, Dinauer M, Podolsky DK, Seed B
Gastroenterology. 2000;119(3):699-705 - PMID: 10982764

Regulated commitment of TNF receptor signaling: a molecular switch for death or activation.

Pimentel-Muiños FX, Seed B
Immunity. 1999;11(6):783-93 - PMID: 10626900

The Epstein-Barr virus oncoprotein latent membrane protein 1 engages the tumor necrosis factor receptor-associated proteins TRADD and receptor-interacting protein (RIP) but does not induce apoptosis or require RIP for NF-kappaB activation.

Izumi KM, Cahir McFarland ED, Ting AT, Riley EA, Seed B, Kieff ED
Mol Cell Biol. 1999;19(8):5759-67 - PMID: 10409763 - PMCID: PMC84426

Membrane compartmentation and the response to antigen.

Xavier R, Seed B
Curr Opin Immunol. 1999;11(3):265-9 - PMID: 10375560

Tumor induction of VEGF promoter activity in stromal cells.

Fukumura D, Xavier R, Sugiura T, Chen Y, Park EC, Lu N, Selig M, Nielsen G, Taksir T, Jain RK, Seed B
Cell. 1998;94(6):715-25 - PMID: 9753319

PPARgamma and colorectal carcinoma: conflicts in a nuclear family.

Seed B
Nat Med. 1998;4(9):1004-5 - PMID: 9734386 - DOI: 10.1038/1990

Muskelin, a novel intracellular mediator of cell adhesive and cytoskeletal responses to thrombospondin-1.

Adams JC, Seed B, Lawler J
EMBO J. 1998;17(17):4964-74 - PMID: 9724633 - PMCID: PMC1170825 - DOI: 10.1093/emboj/17.17.4964

Membrane compartmentation is required for efficient T cell activation.

Xavier R, Brennan T, Li Q, McCormack C, Seed B
Immunity. 1998;8(6):723-32 - PMID: 9655486

Increased immune response elicited by DNA vaccination with a synthetic gp120 sequence with optimized codon usage.

André S, Seed B, Eberle J, Schraut W, Bültmann A, Haas J
J Virol. 1998;72(2):1497-503 - PMID: 9445053 - PMCID: PMC124631

PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines.

Jiang C, Ting AT, Seed B
Nature. 1998;391(6662):82-6 - PMID: 9422509 - DOI: 10.1038/34184

Integrins and inside-out signal transduction: converging signals from PKC and PIP3.

Kolanus W, Seed B
Curr Opin Cell Biol. 1997;9(5):725-31 - PMID: 9330877

RIP mediates tumor necrosis factor receptor 1 activation of NF-kappaB but not Fas/APO-1-initiated apoptosis.

Ting AT, Pimentel-Muiños FX, Seed B
EMBO J. 1996;15(22):6189-96 - PMID: 8947041 - PMCID: PMC452440

Alpha L beta 2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule.

Kolanus W, Nagel W, Schiller B, Zeitlmann L, Godar S, Stockinger H, Seed B
Cell. 1996;86(2):233-42 - PMID: 8706128

Codon usage limitation in the expression of HIV-1 envelope glycoprotein.

Haas J, Park EC, Seed B
Curr Biol. 1996;6(3):315-24 - PMID: 8805248

Clustered syk tyrosine kinase domains trigger phagocytosis.

Greenberg S, Chang P, Wang DC, Xavier R, Seed B
Proc Natl Acad Sci U S A. 1996;93(3):1103-7 - PMID: 8577722 - PMCID: PMC40038

The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination.

Li Z, Otevrel T, Gao Y, Cheng HL, Seed B, Stamato TD, Taccioli GE, Alt FW
Cell. 1995;83(7):1079-89 - PMID: 8548796

PSGL-1 recognition of P-selectin is controlled by a tyrosine sulfation consensus at the PSGL-1 amino terminus.

Pouyani T, Seed B
Cell. 1995;83(2):333-43 - PMID: 7585950

Developments in expression cloning.

Seed B
Curr Opin Biotechnol. 1995;6(5):567-73 - PMID: 7579669

RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death.

Stanger BZ, Leder P, Lee TH, Kim E, Seed B
Cell. 1995;81(4):513-23 - PMID: 7538908

Initiation of signal transduction by receptor aggregation: role of nonreceptor tyrosine kinases.

Seed B
Semin Immunol. 1995;7(1):3-11 - PMID: 7612893

Making agonists of antagonists.

Seed B
Chem Biol. 1994;1(3):125-9 - PMID: 9383381

Association of Raf with the CD3 delta and gamma chains of the T cell receptor-CD3 complex.

Loh C, Romeo C, Seed B, Bruder JT, Rapp U, Rao A
J Biol Chem. 1994;269(12):8817-25 - PMID: 8132616

4A11, a monoclonal antibody recognizing a novel antigen expressed on aberrant vascular endothelium. Upregulation in an in vivo model of contact dermatitis.

Koch AE, Nickoloff BJ, Holgersson J, Seed B, Haines GK, Burrows JC, Leibovich SJ
Am J Pathol. 1994;144(2):244-59 - PMID: 8311112 - PMCID: PMC1887152

Nonreceptor tyrosine kinases in aggregation-mediated cell activation.

Seed B, Kolanus W, Romeo C, Xavier R
Adv Exp Med Biol. 1995;365:111-9 - PMID: 7887297

T cell activation by clustered tyrosine kinases.

Kolanus W, Romeo C, Seed B
Cell. 1993;74(1):171-83 - PMID: 8334702

Antiviral effects of different CD4-immunoglobulin constructs against HIV-1 and SIV: immunological characterization, pharmacokinetic data and in vivo experiments.

Langner KD, Niedrig M, Fultz P, Anderson D, Reiner G, Repke H, Gelderblom H, Seed B, Hilfenhaus J, Zettlmeissl G
Arch Virol. 1993;130(1-2):157-70 - PMID: 8503781

Lineage-independent activation of immune system effector function by myeloid Fc receptors.

Kolanus W, Romeo C, Seed B
EMBO J. 1992;11(13):4861-8 - PMID: 1464313 - PMCID: PMC556962

Marked by a mucin.

Seed B
Curr Biol. 1992;2(9):457-9 - PMID: 15335892

Cloning and functional expression of the T cell activation antigen CD26.

Tanaka T, Camerini D, Seed B, Torimoto Y, Dang NH, Kameoka J, Dahlberg HN, Schlossman SF, Morimoto C
J Immunol. 1992;149(2):481-6 - PMID: 1352530

Sequence requirements for induction of cytolysis by the T cell antigen/Fc receptor zeta chain.

Romeo C, Amiot M, Seed B
Cell. 1992;68(5):889-97 - PMID: 1547489

Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin's disease.

Dürkop H, Latza U, Hummel M, Eitelbach F, Seed B, Stein H
Cell. 1992;68(3):421-7 - PMID: 1310894

Molecular cloning of a cDNA encoding CD34, a sialomucin of human hematopoietic stem cells.

Simmons DL, Satterthwaite AB, Tenen DG, Seed B
J Immunol. 1992;148(1):267-71 - PMID: 1370171

Activation of immune system effector function by T-cell or Fc receptor intracellular domains.

Romeo C, Kolanus W, Amiot M, Seed B
Cold Spring Harb Symp Quant Biol. 1993;57:117-25 - PMID: 1339650

The T cell activation antigen CD27 is a member of the nerve growth factor/tumor necrosis factor receptor gene family.

Camerini D, Walz G, Loenen WA, Borst J, Seed B
J Immunol. 1991;147(9):3165-9 - PMID: 1655907

CD62/P-selectin recognition of myeloid and tumor cell sulfatides.

Aruffo A, Kolanus W, Walz G, Fredman P, Seed B
Cell. 1991;67(1):35-44 - PMID: 1717159

The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins.

Aruffo A, Melnick MB, Linsley PS, Seed B
J Exp Med. 1991;174(4):949-52 - PMID: 1919444 - PMCID: PMC2118957

Cellular immunity to HIV activated by CD4 fused to T cell or Fc receptor polypeptides.

Romeo C, Seed B
Cell. 1991;64(5):1037-46 - PMID: 1900456

The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells.

Stamenkovic I, Aruffo A, Amiot M, Seed B
EMBO J. 1991;10(2):343-8 - PMID: 1991450 - PMCID: PMC452652

Recognition by ELAM-1 of the sialyl-Lex determinant on myeloid and tumor cells.

Walz G, Aruffo A, Kolanus W, Bevilacqua M, Seed B
Science. 1990;250(4984):1132-5 - PMID: 1701275

The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen.

Classon BJ, Williams AF, Willis AC, Seed B, Stamenkovic I
J Exp Med. 1990;172(3):1007 - PMID: 2388030 - PMCID: PMC2188538

Expression of the CD6 T lymphocyte differentiation antigen in normal human brain.

Mayer B, Funke I, Seed B, Riethmüller G, Weiss E
J Neuroimmunol. 1990;29(1-3):193-202 - PMID: 2211985

Identification of the intracytoplasmic region essential for signal transduction through a B cell activation molecule, CD40.

Inui S, Kaisho T, Kikutani H, Stamenkovic I, Seed B, Clark EA, Kishimoto T
Eur J Immunol. 1990;20(8):1747-53 - PMID: 1698631 - DOI: 10.1002/eji.1830200819

CD44 is the principal cell surface receptor for hyaluronate.

Aruffo A, Stamenkovic I, Melnick M, Underhill CB, Seed B
Cell. 1990;61(7):1303-13 - PMID: 1694723

Expression and characterization of human CD4:immunoglobulin fusion proteins.

Zettlmeissl G, Gregersen JP, Duport JM, Mehdi S, Reiner G, Seed B
DNA Cell Biol. 1990;9(5):347-53 - PMID: 2196903 - DOI: 10.1089/dna.1990.9.347

The B-cell antigen CD22 mediates monocyte and erythrocyte adhesion.

Stamenkovic I, Seed B
Nature. 1990;345(6270):74-7 - PMID: 1691828 - DOI: 10.1038/345074a0

Improved genetic selection for screening bacteriophage libraries by homologous recombination in vivo.

Kurnit DM, Seed B
Proc Natl Acad Sci U S A. 1990;87(8):3166-9 - PMID: 2183225 - PMCID: PMC53855

A CD4 domain important for HIV-mediated syncytium formation lies outside the virus binding site.

Camerini D, Seed B
Cell. 1990;60(5):747-54 - PMID: 2107024

Leu-8/TQ1 is the human equivalent of the Mel-14 lymph node homing receptor.

Camerini D, James SP, Stamenkovic I, Seed B
Nature. 1989;342(6245):78-82 - PMID: 2509939 - DOI: 10.1038/342078a0

A human macrophage-associated antigen (CD68) detected by six different monoclonal antibodies.

Micklem K, Rigney E, Cordell J, Simmons D, Stross P, Turley H, Seed B, Mason D
Br J Haematol. 1989;73(1):6-11 - PMID: 2803980

Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c demonstrates a hierarchy of exclusion in fibroblasts.

Aruffo A, Seed B
J Immunol. 1989;143(5):1723-30 - PMID: 2701945

The Two-Component Sensor KinB Acts as a Phosphatase to Regulate Pseudomonas aeruginosa Virulence.

Chand NS, Clatworthy AE, Hung DT
J Bacteriol. 2012;194(23):6537-47 - PMID: 23024348 - PMCID: PMC3497526 - DOI: 10.1128/JB.01168-12

The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.

Lichtenthaler SF, Dominguez DI, Westmeyer GG, Reiss K, Haass C, Saftig P, De Strooper B, Seed B
J Biol Chem. 2003;278(49):48713-9 - PMID: 14507929 - DOI: 10.1074/jbc.M303861200

Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor.

Yamasaki K, Taga T, Hirata Y, Yawata H, Kawanishi Y, Seed B, Taniguchi T, Hirano T, Kishimoto T
Science. 1988;241(4867):825-8 - PMID: 3136546

ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM.

Simmons D, Makgoba MW, Seed B
Nature. 1988;331(6157):624-7 - PMID: 3340213 - DOI: 10.1038/331624a0

Monocyte antigen CD14 is a phospholipid anchored membrane protein.

Simmons DL, Tan S, Tenen DG, Nicholson-Weller A, Seed B
Blood. 1989;73(1):284-9 - PMID: 2462937

B cell maturation antigen, the receptor for a proliferation-inducing ligand and B cell-activating factor of the TNF family, induces antigen presentation in B cells.

Yang M, Hase H, Legarda-Addison D, Varughese L, Seed B, Ting AT
J Immunol. 2005;175(5):2814-24 - PMID: 16116167

Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure.

Seed B, Aruffo A
Proc Natl Acad Sci U S A. 1987;84(10):3365-9 - PMID: 2437578 - PMCID: PMC304871

Isolation of a cDNA encoding CD33, a differentiation antigen of myeloid progenitor cells.

Simmons D, Seed B
J Immunol. 1988;141(8):2797-800 - PMID: 3139766

A PCR primer bank for quantitative gene expression analysis.

Wang X, Seed B
Nucleic Acids Res. 2003;31(24):e154 - PMID: 14654707 - PMCID: PMC291882

Nucleotide sequence of three cDNAs for the human high affinity Fc receptor (FcRI).

Allen JM, Seed B
Nucleic Acids Res. 1988;16(24):11824 - PMID: 2974947 - PMCID: PMC339124

Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo.

Fukumura D, Xu L, Chen Y, Gohongi T, Seed B, Jain RK
Cancer Res. 2001;61(16):6020-4 - PMID: 11507045

Differential transplantability of tumor-associated stromal cells.

Duda DG, Fukumura D, Munn LL, Booth MF, Brown EB, Huang P, Seed B, Jain RK
Cancer Res. 2004;64(17):5920-4 - PMID: 15342367 - DOI: 10.1158/0008-5472.CAN-04-1268

Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation.

Brown E, McKee T, diTomaso E, Pluen A, Seed B, Boucher Y, Jain RK
Nat Med. 2003;9(6):796-800 - PMID: 12754503 - DOI: 10.1038/nm879

The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen.

Classon BJ, Williams AF, Willis AC, Seed B, Stamenkovic I
J Exp Med. 1989;169(4):1497-502 - PMID: 2466944 - PMCID: PMC2189247

Isolation of cDNAs for two distinct human Fc receptors by ligand affinity cloning.

Stengelin S, Stamenkovic I, Seed B
EMBO J. 1988;7(4):1053-9 - PMID: 3402431 - PMCID: PMC454434

Selection of oligonucleotide probes for protein coding sequences.

Wang X, Seed B
Bioinformatics. 2003;19(7):796-802 - PMID: 12724288

Epstein-Barr virus latent infection membrane protein 1 TRAF-binding site induces NIK/IKK alpha-dependent noncanonical NF-kappaB activation.

Luftig M, Yasui T, Soni V, Kang MS, Jacobson N, Cahir-McFarland E, Seed B, Kieff E
Proc Natl Acad Sci U S A. 2003;101(1):141-6 - PMID: 14691250 - PMCID: PMC314152 - DOI: 10.1073/pnas.2237183100

CD19, the earliest differentiation antigen of the B cell lineage, bears three extracellular immunoglobulin-like domains and an Epstein-Barr virus-related cytoplasmic tail.

Stamenkovic I, Seed B
J Exp Med. 1988;168(3):1205-10 - PMID: 2459292 - PMCID: PMC2189043

Molecular cloning of two CD7 (T-cell leukemia antigen) cDNAs by a COS cell expression system.

Aruffo A, Seed B
EMBO J. 1987;6(11):3313-6 - PMID: 3501369 - PMCID: PMC553785

Isolation and expression of functional high-affinity Fc receptor complementary DNAs.

Allen JM, Seed B
Science. 1989;243(4889):378-81 - PMID: 2911749

Syrinx 2A: an improved lambda phage vector designed for screening DNA libraries by recombination in vivo.

Lutz CT, Hollifield WC, Seed B, Davie JM, Huang HV
Proc Natl Acad Sci U S A. 1987;84(13):4379-83 - PMID: 2955406 - PMCID: PMC305092

Improved suppressor tRNA cloning vectors and plasmid-phage recombination.

Huang HV, Little PF, Seed B
Biotechnology. 1989;10:269-83 - PMID: 3061517

Isolation of cDNAs of scrapie-modulated RNAs by subtractive hybridization of a cDNA library.

Duguid JR, Rohwer RG, Seed B
Proc Natl Acad Sci U S A. 1988;85(15):5738-42 - PMID: 2456582 - PMCID: PMC281836

Electrolyte gradient gels for DNA sequencing.

Sheen JY, Seed B
Biotechniques. 1990;6(10):942-4 - PMID: 3273397

The Fc gamma receptor of natural killer cells is a phospholipid-linked membrane protein.

Simmons D, Seed B
Nature. 1988;333(6173):568-70 - PMID: 2967436 - DOI: 10.1038/333568a0

Conformationally constrained spiro C-arylglucosides as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.

Lv B, Feng Y, Dong J, Xu M, Xu B, Zhang W, Sheng Z, Welihinda A, Seed B, Chen Y
ChemMedChem. 2010;5(6):827-31 - PMID: 20414917 - DOI: 10.1002/cmdc.201000051

EGT1442, a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA(1c) levels in db/db mice and prolongs the survival of stroke-prone rats.

Zhang W, Welihinda A, Mechanic J, Ding H, Zhu L, Lu Y, Deng Z, Sheng Z, Lv B, Chen Y, Roberge JY, Seed B, Wang YX
Pharmacol Res. 2011;63(4):284-93 - PMID: 21215314 - DOI: 10.1016/j.phrs.2011.01.001

O-Spiro C-aryl glucosides as novel sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.

Xu B, Lv B, Feng Y, Xu G, Du J, Welihinda A, Sheng Z, Seed B, Chen Y
Bioorg Med Chem Lett. 2009;19(19):5632-5 - PMID: 19700318 - DOI: 10.1016/j.bmcl.2009.08.030

Site-specific gene targeting in mouse embryonic stem cells with intact bacterial artificial chromosomes.

Yang Y, Seed B
Nat Biotechnol. 2003;21(4):447-51 - PMID: 12627171 - DOI: 10.1038/nbt803

Expression and function of CD4 in a murine T-cell hybridoma.

Sleckman BP, Peterson A, Jones WK, Foran JA, Greenstein JL, Seed B, Burakoff SJ
Nature. 1987;328(6128):351-3 - PMID: 3037388 - DOI: 10.1038/328351a0

Exploration of O-spiroketal C-arylglucosides as novel and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.

Lv B, Xu B, Feng Y, Peng K, Xu G, Du J, Zhang L, Zhang W, Zhang T, Zhu L, Ding H, Sheng Z, Welihinda A, Seed B, Chen Y
Bioorg Med Chem Lett. 2009;19(24):6877-81 - PMID: 19896374 - DOI: 10.1016/j.bmcl.2009.10.088

Genetic analysis of monoclonal antibody and HIV binding sites on the human lymphocyte antigen CD4.

Peterson A, Seed B
Cell. 1988;54(1):65-72 - PMID: 2454749

C-aryl glucosides substituted at the 4'-position as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.

Xu B, Feng Y, Cheng H, Song Y, Lv B, Wu Y, Wang C, Li S, Xu M, Du J, Peng K, Dong J, Zhang W, Zhang T, Zhu L, Ding H, Sheng Z, Welihinda A, Roberge JY, Seed B, Chen Y
Bioorg Med Chem Lett. 2011;21(15):4465-70 - PMID: 21737266 - DOI: 10.1016/j.bmcl.2011.06.032

Efficient and stable retroviral transfection of ovine endothelial cells with green fluorescent protein for cardiovascular tissue engineering.

Afting M, Stock UA, Nasseri B, Pomerantseva I, Seed B, Vacanti JP
Tissue Eng. 2003;9(1):137-41 - PMID: 12625962 - DOI: 10.1089/107632703762687618

Identification of two sequences in the cytoplasmic tail of the human immunodeficiency virus type 1 envelope glycoprotein that inhibit cell surface expression.

Bültmann A, Muranyi W, Seed B, Haas J
J Virol. 2001;75(11):5263-76 - PMID: 11333908 - PMCID: PMC114932 - DOI: 10.1128/JVI.75.11.5263-5276.2001

CD36 directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes.

Oquendo P, Hundt E, Lawler J, Seed B
Cell. 1989;58(1):95-101 - PMID: 2473841

A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family.

Stamenkovic I, Amiot M, Pesando JM, Seed B
Cell. 1989;56(6):1057-62 - PMID: 2466575

Identification of eosinophil lineage-committed progenitors in the murine bone marrow.

Iwasaki H, Mizuno S, Mayfield R, Shigematsu H, Arinobu Y, Seed B, Gurish MF, Takatsu K, Akashi K
J Exp Med. 2005;201(12):1891-7 - PMID: 15955840 - PMCID: PMC2212039 - DOI: 10.1084/jem.20050548

Endoplasmic reticulum chaperone gp96 is required for innate immunity but not cell viability.

Randow F, Seed B
Nat Cell Biol. 2001;3(10):891-6 - PMID: 11584270 - DOI: 10.1038/ncb1001-891

ortho-Substituted C-aryl glucosides as highly potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.

Xu B, Feng Y, Lv B, Xu G, Zhang L, Du J, Peng K, Xu M, Dong J, Zhang W, Zhang T, Zhu L, Ding H, Sheng Z, Welihinda A, Seed B, Chen Y
Bioorg Med Chem. 2010;18(12):4422-32 - PMID: 20576578 - DOI: 10.1016/j.bmc.2010.04.088

Expression of the T-cell surface molecule CD2 and an epitope-loss CD2 mutant to define the role of lymphocyte function-associated antigen 3 (LFA-3) in T-cell activation.

Bierer BE, Peterson A, Barbosa J, Seed B, Burakoff SJ
Proc Natl Acad Sci U S A. 1988;85(4):1194-8 - PMID: 2448792 - PMCID: PMC279733

Analysis of two cDNA clones encoding the B lymphocyte antigen CD20 (B1, Bp35), a type III integral membrane protein.

Stamenkovic I, Seed B
J Exp Med. 1988;167(6):1975-80 - PMID: 3260267 - PMCID: PMC2189672

Targeted disruption of the murine Fanconi anemia gene, Fancg/Xrcc9.

Yang Y, Kuang Y, Montes De Oca R, Hays T, Moreau L, Lu N, Seed B, D'Andrea AD
Blood. 2001;98(12):3435-40 - PMID: 11719385

Functional analysis of CD2, CD4, and CD8 in T-cell activation.

Bierer BE, Greenstein JL, Sleckman B, Ratnofsky S, Peterson A, Seed B, Burakoff SJ
Ann N Y Acad Sci. 1988;532:199-206 - PMID: 3052208

An LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2.

Seed B
Nature. 1987;329(6142):840-2 - PMID: 3313052 - DOI: 10.1038/329840a0

Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system.

Aruffo A, Seed B
Proc Natl Acad Sci U S A. 1987;84(23):8573-7 - PMID: 2825196 - PMCID: PMC299587

A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas.

Stamenkovic I, Clark EA, Seed B
EMBO J. 1989;8(5):1403-10 - PMID: 2475341 - PMCID: PMC400967

Monoclonal antibody and ligand binding sites of the T cell erythrocyte receptor (CD2).

Peterson A, Seed B
Nature. 1987;329(6142):842-6 - PMID: 2444890 - DOI: 10.1038/329842a0

Lipid rafts and pseudotyping.

Pickl WF, Pimentel-Muiños FX, Seed B
J Virol. 2001;75(15):7175-83 - PMID: 11435598 - PMCID: PMC114446 - DOI: 10.1128/JVI.75.15.7175-7183.2001

Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins.

Bevilacqua MP, Stengelin S, Gimbrone MA, Seed B
Science. 1989;243(4895):1160-5 - PMID: 2466335

Purification of genomic sequences from bacteriophage libraries by recombination and selection in vivo.

Seed B
Nucleic Acids Res. 1983;11(8):2427-45 - PMID: 6856467 - PMCID: PMC325894

A simple phase-extraction assay for chloramphenicol acyltransferase activity.

Seed B, Sheen JY
Gene. 1988;67(2):271-7 - PMID: 3169576

Plasmid vectors for the rapid isolation and transcriptional analysis of human beta-globin gene alleles.

Little PF, Treisman R, Bierut L, Seed B, Maniatis T
Mol Biol Med. 1983;1(5):473-88 - PMID: 6094959

Myelinated, synapsing cultures of murine spinal cord--validation as an in vitro model of the central nervous system.

Thomson CE, McCulloch M, Sorenson A, Barnett SC, Seed BV, Griffiths IR, McLaughlin M
Eur J Neurosci. 2008;28(8):1518-35 - PMID: 18793322 - PMCID: PMC2777255 - DOI: 10.1111/j.1460-9568.2008.06415.x

The knockout mouse project.

Austin CP, Battey JF, Bradley A, Bucan M, Capecchi M, Collins FS, Dove WF, Duyk G, Dymecki S, Eppig JT, Grieder FB, Heintz N, Hicks G, Insel TR, Joyner A, Koller BH, Lloyd KC, Magnuson T, Moore MW, Nagy A, Pollock JD, Roses AD, Sands AT, Seed B, Skarnes WC, Snoddy J, Soriano P, Stewart DJ, Stewart F, Stillman B, Varmus H, Varticovski L, Verma IM, Vogt TF, von Melchner H, Witkowski J, Woychik RP, Wurst W, Yancopoulos GD, Young SG, Zambrowicz B
Nat Genet. 2004;36(9):921-4 - PMID: 15340423 - PMCID: PMC2716027 - DOI: 10.1038/ng0904-921

A comparison of postmigration and migration-coupled mismatch correction mechanisms for branch migration-mediated gene conversion.

Seed B
Genetics. 1984;106(3):549-67 - PMID: 6706113 - PMCID: PMC1224256

Minimal size plasmids containing an M13 origin for production of single-strand transducing particles.

Levinson A, Silver D, Seed B
J Mol Appl Genet. 1985;2(6):507-17 - PMID: 6099398

Theoretical study of the fraction of a long-chain DNA that can be incorporated in a recombinant DNA partial-digest library.

Seed B
Biopolymers. 1982;21(9):1793-810 - PMID: 7126756 - DOI: 10.1002/bip.360210909

Representation of DNA sequences in recombinant DNA libraries prepared by restriction enzyme partial digestion.

Seed B, Parker RC, Davidson N
Gene. 1982;19(2):201-9 - PMID: 6293929

Diazotizable arylamine cellulose papers for the coupling and hybridization of nucleic acids.

Seed B
Nucleic Acids Res. 1982;10(5):1799-810 - PMID: 7071022 - PMCID: PMC320567

Two-dimensional agarose gel electrophoresis "SeaPlaque" agarose dimension.

Parker RC, Seed B
Methods Enzymol. 1980;65(1):358-63 - PMID: 6246359

Systematics-guided bioprospecting for bioactive microbial natural products.

Liu X, Bolla K, Ashforth EJ, Zhuo Y, Gao H, Huang P, Stanley SA, Hung DT, Zhang L
Antonie Van Leeuwenhoek. 2011;101(1):55-66 - PMID: 22086462 - DOI: 10.1007/s10482-011-9671-1

Bile acids stimulate biofilm formation in Vibrio cholerae.

Hung DT, Zhu J, Sturtevant D, Mekalanos JJ
Mol Microbiol. 2006;59(1):193-201 - PMID: 16359328 - DOI: 10.1111/j.1365-2958.2005.04846.x

Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization.

Hung DT, Shakhnovich EA, Pierson E, Mekalanos JJ
Science. 2005;310(5748):670-4 - PMID: 16223984 - DOI: 10.1126/science.1116739

Bile acids induce cholera toxin expression in Vibrio cholerae in a ToxT-independent manner.

Hung DT, Mekalanos JJ
Proc Natl Acad Sci U S A. 2005;102(8):3028-33 - PMID: 15699331 - PMCID: PMC549475 - DOI: 10.1073/pnas.0409559102

Ductal lavage and the clinical management of women at high risk for breast carcinoma: a commentary.

O'Shaughnessy JA, Ljung BM, Dooley WC, Chang J, Kuerer HM, Hung DT, Grant MD, Khan SA, Phillips RF, Duvall K, Euhus DM, King BL, Anderson BO, Troyan SL, Kim J, Veronesi U, Cazzaniga M
Cancer. 2002;94(2):292-8 - PMID: 11900214 - DOI: 10.1002/cncr.10238

Ductal lavage for detection of cellular atypia in women at high risk for breast cancer.

Dooley WC, Ljung BM, Veronesi U, Cazzaniga M, Elledge RM, O'Shaughnessy JA, Kuerer HM, Hung DT, Khan SA, Phillips RF, Ganz PA, Euhus DM, Esserman LJ, Haffty BG, King BL, Kelley MC, Anderson MM, Schmit PJ, Clark RR, Kass FC, Anderson BO, Troyan SL, Arias RD, Quiring JN, Love SM, Page DL, King EB
J Natl Cancer Inst. 2001;93(21):1624-32 - PMID: 11698566

Detection of breast cancer cells in ductal lavage fluid by methylation-specific PCR.

Evron E, Dooley WC, Umbricht CB, Rosenthal D, Sacchi N, Gabrielson E, Soito AB, Hung DT, Ljung B, Davidson NE, Sukumar S
Lancet. 2001;357(9265):1335-6 - PMID: 11343741

Understanding and controlling the cell cycle with natural products.

Hung DT, Jamison TF, Schreiber SL
Chem Biol. 1996;3(8):623-39 - PMID: 8807895

(+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest.

Hung DT, Chen J, Schreiber SL
Chem Biol. 1996;3(4):287-93 - PMID: 8807856

Distinct binding and cellular properties of synthetic (+)- and (-)-discodermolides.

Hung DT, Nerenberg JB, Schreiber SL
Chem Biol. 1994;1(1):67-71 - PMID: 9383372

Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: roles of calcineurin binding and cellular location.

Bram RJ, Hung DT, Martin PK, Schreiber SL, Crabtree GR
Mol Cell Biol. 1993;13(8):4760-9 - PMID: 7687744 - PMCID: PMC360102

The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase.

Hung DT, Wong YH, Vu TK, Coughlin SR
J Biol Chem. 1992;267(29):20831-4 - PMID: 1328213

Tethered ligand agonist peptides. Structural requirements for thrombin receptor activation reveal mechanism of proteolytic unmasking of agonist function.

Scarborough RM, Naughton MA, Teng W, Hung DT, Rose J, Vu TK, Wheaton VI, Turck CW, Coughlin SR
J Biol Chem. 1992;267(19):13146-9 - PMID: 1320011

cDNA cloning of a human 25 kDa FK506 and rapamycin binding protein.

Hung DT, Schreiber SL
Biochem Biophys Res Commun. 1992;184(2):733-8 - PMID: 1374240

HLA-A2-peptide complexes: refolding and crystallization of molecules expressed in Escherichia coli and complexed with single antigenic peptides.

Garboczi DN, Hung DT, Wiley DC
Proc Natl Acad Sci U S A. 1992;89(8):3429-33 - PMID: 1565634 - PMCID: PMC48881

Cloned platelet thrombin receptor is necessary for thrombin-induced platelet activation.

Hung DT, Vu TK, Wheaton VI, Ishii K, Coughlin SR
J Clin Invest. 1992;89(4):1350-3 - PMID: 1313452 - PMCID: PMC442997 - DOI: 10.1172/JCI115721

"Mirror image" antagonists of thrombin-induced platelet activation based on thrombin receptor structure.

Hung DT, Vu TK, Wheaton VI, Charo IF, Nelken NA, Esmon N, Esmon CT, Coughlin SR
J Clin Invest. 1992;89(2):444-50 - PMID: 1310695 - PMCID: PMC442871 - DOI: 10.1172/JCI115604

Characterization of a functional thrombin receptor. Issues and opportunities.

Coughlin SR, Vu TK, Hung DT, Wheaton VI
J Clin Invest. 1992;89(2):351-5 - PMID: 1310691 - PMCID: PMC442859 - DOI: 10.1172/JCI115592

Thrombin-induced events in non-platelet cells are mediated by the unique proteolytic mechanism established for the cloned platelet thrombin receptor.

Hung DT, Vu TH, Nelken NA, Coughlin SR
J Cell Biol. 1992;116(3):827-32 - PMID: 1309820 - PMCID: PMC2289317

Thrombin receptor structure and function.

Coughlin SR, Scarborough RM, Vu TK, Hung DT
Cold Spring Harb Symp Quant Biol. 1993;57:149-54 - PMID: 1339654

Expression cloning and characterization of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation.

Coughlin SR, Vu TK, Hung DT, Wheaton VI
Semin Thromb Hemost. 1992;18(2):161-6 - PMID: 1321504 - DOI: 10.1055/s-2007-1002422

Domains specifying thrombin-receptor interaction.

Vu TK, Wheaton VI, Hung DT, Charo I, Coughlin SR
Nature. 1991;353(6345):674-7 - PMID: 1717851 - DOI: 10.1038/353674a0

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation.

Vu TK, Hung DT, Wheaton VI, Coughlin SR
Cell. 1991;64(6):1057-68 - PMID: 1672265

Decreased cell kill of vincristine and methotrexate against 9L rat brain tumor cells in vitro caused by alpha-difluoromethylornithine-induced polyamine depletion.

Alhonen-Hongisto L, Hung DT, Deen DF, Marton LJ
Cancer Res. 1984;44(10):4440-2 - PMID: 6432313

Potentiation of 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity in 9L rat brain tumor cells by methylglyoxal-bis(guanylhydrazone), an inhibitor of S-adenosyl-L-methionine decarboxylase.

Hung DT, Oredsson SM, Pegg AE, Deen DF, Marton LJ
Eur J Cancer Clin Oncol. 1984;20(3):417-20 - PMID: 6538500

Depletion of intracellular polyamines may alter DNA conformation in 9L rat brain tumor cells.

Hung DT, Marton LJ, Deen DF, Shafer RH
Science. 1983;221(4608):368-70 - PMID: 6408733

Sensitization of 9L rat brain gliosarcoma cells to 1,3-bis(2-chloroethyl)-1-nitrosourea by alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor.

Hung DT, Deen DF, Seidenfeld J, Marton LJ
Cancer Res. 1981;41(7):2783-5 - PMID: 6788362

Preparation of an ecdysone immunogen for radioimmunoassay work.

Hung DT, Benner SA, Williams CM
J Biol Chem. 1980;255(13):6047-8 - PMID: 7190146

Genetic strategy for analyzing specificity of dimer formation: Escherichia coli cyclic AMP receptor protein mutant altered in its dimerization specificity.

Joung JK, Chung EH, King G, Yu C, Hirsh AS, Hochschild A
Genes Dev. 1995;9(23):2986-96 - PMID: 7498794

Synergistic activation of transcription by bacteriophage lambda cI protein and E. coli cAMP receptor protein.

Joung JK, Koepp DM, Hochschild A
Science. 1994;265(5180):1863-6 - PMID: 8091212

Highly specific zinc finger proteins obtained by directed domain shuffling and cell-based selection.

Hurt JA, Thibodeau SA, Hirsh AS, Pabo CO, Joung JK
Proc Natl Acad Sci U S A. 2003;100(21):12271-6 - PMID: 14527993 - PMCID: PMC218748 - DOI: 10.1073/pnas.2135381100

Identifying and modifying protein-DNA and protein-protein interactions using a bacterial two-hybrid selection system.

Joung JK
J Cell Biochem Suppl. 2002;Suppl 37:53-7 - PMID: 11842428

Activation of prokaryotic transcription through arbitrary protein-protein contacts.

Dove SL, Joung JK, Hochschild A
Nature. 1997;386(6625):627-30 - PMID: 9121589 - DOI: 10.1038/386627a0

Synergistic activation of transcription by Escherichia coli cAMP receptor protein.

Joung JK, Le LU, Hochschild A
Proc Natl Acad Sci U S A. 1993;90(7):3083-7 - PMID: 7681995 - PMCID: PMC46241

A combined yeast/bacteria two-hybrid system: development and evaluation.

Serebriiskii IG, Fang R, Latypova E, Hopkins R, Vinson C, Joung JK, Golemis EA
Mol Cell Proteomics. 2005;4(6):819-26 - PMID: 15781424 - PMCID: PMC2670611 - DOI: 10.1074/mcp.T500005-MCP200

Repression of phase-variable cup gene expression by H-NS-like proteins in Pseudomonas aeruginosa.

Vallet-Gely I, Donovan KE, Fang R, Joung JK, Dove SL
Proc Natl Acad Sci U S A. 2005;102(31):11082-7 - PMID: 16043713 - PMCID: PMC1182424 - DOI: 10.1073/pnas.0502663102

Allosteric inhibition of zinc-finger binding in the major groove of DNA by minor-groove binding ligands.

Nguyen-Hackley DH, Ramm E, Taylor CM, Joung JK, Dervan PB, Pabo CO
Biochemistry. 2004;43(13):3880-90 - PMID: 15049695 - DOI: 10.1021/bi030223c

A bacterial two-hybrid selection system for studying protein-DNA and protein-protein interactions.

Joung JK, Ramm EI, Pabo CO
Proc Natl Acad Sci U S A. 2000;97(13):7382-7 - PMID: 10852947 - PMCID: PMC16554 - DOI: 10.1073/pnas.110149297

High-throughput beta-galactosidase assay for bacterial cell-based reporter systems.

Thibodeau SA, Fang R, Joung JK
Biotechniques. 2004;36(3):410-5 - PMID: 15038156

Apoptotic cells and innate immune stimuli combine to regulate macrophage cytokine secretion.

Lucas M, Stuart LM, Savill J, Lacy-Hulbert A
J Immunol. 2003;171(5):2610-5 - PMID: 12928413

Response to Staphylococcus aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain.

Stuart LM, Deng J, Silver JM, Takahashi K, Tseng AA, Hennessy EJ, Ezekowitz RA, Moore KJ
J Cell Biol. 2005;170(3):477-85 - PMID: 16061696 - PMCID: PMC2171464 - DOI: 10.1083/jcb.200501113

Mannose-binding lectin-deficient mice display defective apoptotic cell clearance but no autoimmune phenotype.

Stuart LM, Takahashi K, Shi L, Savill J, Ezekowitz RA
J Immunol. 2005;174(6):3220-6 - PMID: 15749852

Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila.

Kocks C, Cho JH, Nehme N, Ulvila J, Pearson AM, Meister M, Strom C, Conto SL, Hetru C, Stuart LM, Stehle T, Hoffmann JA, Reichhart JM, Ferrandon D, Rämet M, Ezekowitz RA
Cell. 2005;123(2):335-46 - PMID: 16239149 - DOI: 10.1016/j.cell.2005.08.034

Inhibitory effects of apoptotic cell ingestion upon endotoxin-driven myeloid dendritic cell maturation.

Stuart LM, Lucas M, Simpson C, Lamb J, Savill J, Lacy-Hulbert A
J Immunol. 2002;168(4):1627-35 - PMID: 11823490

Phagocytosis: elegant complexity.

Stuart LM, Ezekowitz RA
Immunity. 2005;22(5):539-50 - PMID: 15894272 - DOI: 10.1016/j.immuni.2005.05.002

Clinical review. Risk factors for low bone mass-related fractures in men: a systematic review and meta-analysis.

Drake MT, Murad MH, Mauck KF, Lane MA, Undavalli C, Elraiyah T, Stuart LM, Prasad C, Shahrour A, Mullan RJ, Hazem A, Erwin PJ, Montori VM
J Clin Endocrinol Metab. 2012;97(6):1861-70 - PMID: 22466344 - DOI: 10.1210/jc.2011-3058

Clinical review. Comparative effectiveness of drug treatments to prevent fragility fractures: a systematic review and network meta-analysis.

Murad MH, Drake MT, Mullan RJ, Mauck KF, Stuart LM, Lane MA, Abu Elnour NO, Erwin PJ, Hazem A, Puhan MA, Li T, Montori VM
J Clin Endocrinol Metab. 2012;97(6):1871-80 - PMID: 22466336 - DOI: 10.1210/jc.2011-3060

Domestic violence: old problems, new approaches.

Stuart LM
Links (Oxford). 1997;:4 - PMID: 12320799

Deep inelastic scattering of polarized electrons by polarized 3He and the study of the neutron spin structure.

Anthony PL, Arnold RG, Band HR, Borel H, Bosted PE, Breton V, Cates GD, Chupp TE, Dietrich FS, Dunne J, Erbacher R, Fellbaum J, Fonvieille H, Gearhart R, Holmes R, Hughes EW, Johnson JR, Kawall D, Keppel C, Kuhn SE, Lombard-Nelsen RM, Marroncle J, Maruyama T, Meyer W, Meziani Z, Middleton H, Morgenstern J, Newbury NR, Petratos GG, Pitthan R, Prepost R, Roblin Y, Rock SE, Rokni SH, Shapiro G, Smith T, Souder PA, Spengos M, Staley F, Stuart LM, Szalata ZM, Terrien Y, Thompson AK, White JL, Woo ...
Phys Rev D Part Fields. 1996;54(11):6620-6650 - PMID: 10020671

A soldier in respiratory distress.

Stuart LM, Rice PS, Lloyd G, Beale RJ
Lancet. 1996;347(8993):30 - PMID: 8531548

Measurements of the electric and magnetic form factors of the proton from Q2=1.75 to 8.83 (GeV/c)2.

Andivahis L, Bosted PE, Lung A, Stuart LM, Alster J, Arnold RG, Chang CC, Dietrich FS, Dodge W, Gearhart R, Gomez J, Griffioen KA, Hicks RS, Hyde-Wright CE, Keppel C, Kuhn SE, Lichtenstadt J, Miskimen RA, Peterson GA, Petratos GG, Rock SE, Rokni S, Sakumoto WK, Spengos M, Swartz K, Szalata Z, Tao LH
Phys Rev D Part Fields. 1994;50(9):5491-5517 - PMID: 10018207

Determination of the neutron spin structure function.

Anthony PL, Arnold RG, Band HR, Borel H, Bosted PE, Breton V, Cates GD, Chupp TE, Dietrich FS, Dunne J, Erbacher R, Fellbaum J, Fonvieille H, Gearhart R, Holmes R, Hughes EW, Johnson JR, Kawall D, Keppel C, Kuhn SE, Lombard-Nelsen RM, Marroncle J, Maruyama T, Meyer W, Meziani Z, Middleton H, Morgenstern J, Newbury NR, Petratos GG, Pitthan R, Prepost R, Roblin Y, Rock SE, Rokni SH, Shapiro G, Smith T, Souder PA, Spengos M, Staley F, Stuart LM, Szalata ZM, Terrien Y, Thompson AK, White JL, Woo ...
Phys Rev Lett. 1993;71(7):959-962 - PMID: 10055413 - DOI: 10.1103/PhysRevLett.71.959

Measurements of the electric and magnetic form factors of the neutron from Q2=1.75 to 4.00 (GeV/c)2.

Lung A, Stuart LM, Bosted PE, Andivahis L, Alster J, Arnold RG, Chang CC, Dietrich FS, Dodge WR, Gearhart R, Gomez J, Griffioen KA, Hicks RS, Hyde-Wright CE, Keppel C, Kuhn SE, Lichtenstadt J, Miskimen RA, Peterson GA, Petratos GG, Rock SE, Rokni SH, Sakumoto WK, Spengos M, Swartz K, Szalata Z, Tao LH
Phys Rev Lett. 1993;70(6):718-721 - PMID: 10054186 - DOI: 10.1103/PhysRevLett.70.718

Measurements of nu W2 and R= sigma L/ sigma T from inelastic electron-aluminum scattering near x=1.

Bosted PE, Lung A, Andivahis L, Stuart LM, Alster J, Arnold RG, Chang CC, Dietrich FS, Dodge W, Gearhart R, Gomez J, Griffioen KA, Hicks RS, Hyde-Wright CE, Keppel C, Kuhn SE, Lichtenstadt J, Miskimen RA, Peterson GA, Petratos GG, Rock SE, Rokni S, Sakumoto WK, Spengos M, Swartz K, Szalata Z, Tao LH
Phys Rev C Nucl Phys. 1992;46(6):2505-2515 - PMID: 9968381

Measurements of the electric and magnetic form factors of the proton from Q2=1.75 to 8.83 (GeV/c)2.

Bosted PE, Andivahis L, Lung A, Stuart LM, Alster J, Arnold RG, Chang CC, Dietrich FS, Dodge W, Gearhart R, Gomez J, Griffioen KA, Hicks RS, Hyde-Wright CE, Keppel C, Kuhn SE, Lichtenstadt J, Miskimen RA, Peterson GA, Petratos GG, Rock SE, Rokni S, Sakumoto WK, Spengos M, Swartz K, Szalata Z, Tao LH
Phys Rev Lett. 1992;68(26):3841-3844 - PMID: 10045818 - DOI: 10.1103/PhysRevLett.68.3841

A critique of materials submitted by dentists to dental laboratories for the fabrication of removable partial dentures.

Hardy F, Stuart LM
Quintessence Dent Technol. 1983;7(2):93-5 - PMID: 6344150

Laboratory prescriptions for removable partial dentures.

Hardy F, Stuart LM, Travaglini EA
J Md State Dent Assoc. 1982;25(3):108-9 - PMID: 6757356

Are you expecting a miracle?

Hardy F, Stuart LM, Ross LA
J Md State Dent Assoc. 1982;25(1):19-20 - PMID: 7042882

TNA synthesis by DNA polymerases.

Chaput JC, Szostak JW
J Am Chem Soc. 2003;125(31):9274-5 - PMID: 12889939 - DOI: 10.1021/ja035917n

Ribosomal synthesis of unnatural peptides.

Josephson K, Hartman MC, Szostak JW
J Am Chem Soc. 2005;127(33):11727-35 - PMID: 16104750 - DOI: 10.1021/ja0515809

Point mutations in the yeast histone H4 gene prevent silencing of the silent mating type locus HML.

Park EC, Szostak JW
Mol Cell Biol. 1990;10(9):4932-4 - PMID: 2117703 - PMCID: PMC361112

Construction of specific chromosomal rearrangements in yeast.

Sugawara N, Szostak JW
Methods Enzymol. 1983;101:269-78 - PMID: 6310329

ARD1 and NAT1 proteins form a complex that has N-terminal acetyltransferase activity.

Park EC, Szostak JW
EMBO J. 1992;11(6):2087-93 - PMID: 1600941 - PMCID: PMC556675

Nonenzymatic, template-directed ligation of oligoribonucleotides is highly regioselective for the formation of 3'-5' phosphodiester bonds.

Rohatgi R, Bartel DP, Szostak JW
J Am Chem Soc. 1996;118(14):3340-4 - PMID: 11539268

A small aptamer with strong and specific recognition of the triphosphate of ATP.

Sazani PL, Larralde R, Szostak JW
J Am Chem Soc. 2004;126(27):8370-1 - PMID: 15237981 - PMCID: PMC4983724 - DOI: 10.1021/ja049171k

Yeast transformation: a model system for the study of recombination.

Orr-Weaver TL, Szostak JW, Rothstein RJ
Proc Natl Acad Sci U S A. 1981;78(10):6354-8 - PMID: 6273866 - PMCID: PMC349037

Informational complexity and functional activity of RNA structures.

Carothers JM, Oestreich SC, Davis JH, Szostak JW
J Am Chem Soc. 2004;126(16):5130-7 - PMID: 15099096 - PMCID: PMC5042360 - DOI: 10.1021/ja031504a

A simple method for 3'-labeling of RNA.

Huang Z, Szostak JW
Nucleic Acids Res. 1996;24(21):4360-1 - PMID: 8932396 - PMCID: PMC146232

In vitro selection of catalytic RNAs.

Chapman KB, Szostak JW
Curr Opin Struct Biol. 1997;4:618-22 - PMID: 11539575

Synthesis of alpha-L-threofuranosyl nucleoside triphosphates (tNTPs).

Zou K, Horhota A, Yu B, Szostak JW, McLaughlin LW
Org Lett. 2005;7(8):1485-7 - PMID: 15816733 - PMCID: PMC5022784 - DOI: 10.1021/ol050081+

Construction of artificial chromosomes in yeast.

Murray AW, Szostak JW
Nature. 1983;305(5931):189-93 - PMID: 6350893

Optimized synthesis of RNA-protein fusions for in vitro protein selection.

Liu R, Barrick JE, Szostak JW, Roberts RW
Methods Enzymol. 2000;318:268-93 - PMID: 10889994

Yeast recombination: the association between double-strand gap repair and crossing-over.

Orr-Weaver TL, Szostak JW
Proc Natl Acad Sci U S A. 1983;80(14):4417-21 - PMID: 6308623 - PMCID: PMC384049

Characterization of two telomeric DNA processing reactions in Saccharomyces cerevisiae.

Murray AW, Claus TE, Szostak JW
Mol Cell Biol. 1988;8(11):4642-50 - PMID: 3062364 - PMCID: PMC365553

A kinetic study of the growth of fatty acid vesicles.

Chen IA, Szostak JW
Biophys J. 2004;87(2):988-98 - PMID: 15298905 - PMCID: PMC1304506 - DOI: 10.1529/biophysj.104.039875

Insertion of a genetic marker into the ribosomal DNA of yeast.

Szostak JW, Wu R
Plasmid. 1979;2(4):536-54 - PMID: 394173

Extensive 3'-overhanging, single-stranded DNA associated with the meiosis-specific double-strand breaks at the ARG4 recombination initiation site.

Sun H, Treco D, Szostak JW
Cell. 1991;64(6):1155-61 - PMID: 2004421

Ribozyme-catalyzed tRNA aminoacylation.

Lee N, Bessho Y, Wei K, Szostak JW, Suga H
Nat Struct Biol. 2000;7(1):28-33 - PMID: 10625423 - DOI: 10.1038/71225

Shrink-wrap vesicles.

Fujikawa SM, Chen IA, Szostak JW
Langmuir. 2005;21(26):12124-9 - PMID: 16342983 - PMCID: PMC2548281 - DOI: 10.1021/la052590q

A poly(dA.dT) tract is a component of the recombination initiation site at the ARG4 locus in Saccharomyces cerevisiae.

Schultes NP, Szostak JW
Mol Cell Biol. 1991;11(1):322-8 - PMID: 1986228 - PMCID: PMC359622

Ribozymes. Evolution ex vivo.

Szostak JW
Nature. 1993;361(6408):119-20 - PMID: 7678448 - DOI: 10.1038/361119a0

The emergence of competition between model protocells.

Chen IA, Roberts RW, Szostak JW
Science. 2004;305(5689):1474-6 - PMID: 15353806 - PMCID: PMC4484590 - DOI: 10.1126/science.1100757

Telomeric repeat from T. thermophila cross hybridizes with human telomeres.

Allshire RC, Gosden JR, Cross SH, Cranston G, Rout D, Sugawara N, Szostak JW, Fantes PA, Hastie ND
Nature. 1988;332(6165):656-9 - PMID: 2833706 - DOI: 10.1038/332656a0

Yeast vectors with negative selection.

Brown PA, Szostak JW
Methods Enzymol. 1983;101:278-90 - PMID: 6310330

Mutant ATP-binding RNA aptamers reveal the structural basis for ligand binding.

Dieckmann T, Butcher SE, Sassanfar M, Szostak JW, Feigon J
J Mol Biol. 1997;273(2):467-78 - PMID: 9344753 - DOI: 10.1006/jmbi.1997.1329

RNA-catalysed synthesis of complementary-strand RNA.

Doudna JA, Szostak JW
Nature. 1989;339(6225):519-22 - PMID: 2660003 - DOI: 10.1038/339519a0

Isolation of new ribozymes from a large pool of random sequences [see comment].

Bartel DP, Szostak JW
Science. 1993;261(5127):1411-8 - PMID: 7690155

Membrane growth can generate a transmembrane pH gradient in fatty acid vesicles.

Chen IA, Szostak JW
Proc Natl Acad Sci U S A. 2004;101(21):7965-70 - PMID: 15148394 - PMCID: PMC419540 - DOI: 10.1073/pnas.0308045101

Experimental models of primitive cellular compartments: encapsulation, growth, and division.

Hanczyc MM, Fujikawa SM, Szostak JW
Science. 2003;302(5645):618-22 - PMID: 14576428 - PMCID: PMC4484575 - DOI: 10.1126/science.1089904

HIV-1 Rev regulation involves recognition of non-Watson-Crick base pairs in viral RNA.

Bartel DP, Zapp ML, Green MR, Szostak JW
Cell. 1991;67(3):529-36 - PMID: 1934059

In vitro selection of RNA aptamers specific for cyanocobalamin.

Lorsch JR, Szostak JW
Biochemistry. 1994;33(4):973-82 - PMID: 7508262

RNA aptamers that bind flavin and nicotinamide redox cofactors.

Lauhon CT, Szostak JW
J Am Chem Soc. 1995;117(4):1246-57 - PMID: 11539282

High fidelity TNA synthesis by Therminator polymerase.

Ichida JK, Horhota A, Zou K, McLaughlin LW, Szostak JW
Nucleic Acids Res. 2005;33(16):5219-25 - PMID: 16157867 - PMCID: PMC1214552 - DOI: 10.1093/nar/gki840

A mutant with a defect in telomere elongation leads to senescence in yeast.

Lundblad V, Szostak JW
Cell. 1989;57(4):633-43 - PMID: 2655926

Saccharomyces cerevisiae homoserine kinase is homologous to prokaryotic homoserine kinases.

Schultes NP, Ellington AD, Cherry JM, Szostak JW
Gene. 1990;96(2):177-80 - PMID: 2176637

Gene conversion adjacent to regions of double-strand break repair.

Orr-Weaver TL, Nicolas A, Szostak JW
Mol Cell Biol. 1988;8(12):5292-8 - PMID: 3072478 - PMCID: PMC365631

Genetic and physical analyses of sister chromatid exchange in yeast meiosis.

Sun H, Dawson D, Szostak JW
Mol Cell Biol. 1991;11(12):6328-36 - PMID: 1944292 - PMCID: PMC361828

Transfer of yeast telomeres to linear plasmids by recombination.

Dunn B, Szauter P, Pardue ML, Szostak JW
Cell. 1984;39(1):191-201 - PMID: 6091911

Stereochemical course of catalysis by the Tetrahymena ribozyme.

Rajagopal J, Doudna JA, Szostak JW
Science. 1989;244(4905):692-4 - PMID: 2470151

Cloning yeast telomeres on linear plasmid vectors.

Szostak JW, Blackburn EH
Cell. 1982;29(1):245-55 - PMID: 6286143

Selective labeling and detection of specific RNAs in an RNA mixture.

Huang Z, Szostak JW
Anal Biochem. 2003;315(1):129-33 - PMID: 12672421

Chemical synthesis of oligoribonucleotides containing 2-aminopurine: substrates for the investigation of ribozyme function.

Doudna JA, Szostak JW, Rich A, Usman N
J Org Chem. 1990;55(21):5547-9 - PMID: 11540922

Specific binding of a synthetic oligodeoxyribonucleotide to yeast cytochrome c mRNA.

Szostak JW, Stiles JI, Bahl CP, Wu R
Nature. 1977;265(5589):61-3 - PMID: 189200

In vitro genetic analysis of the hinge region between helical elements P5-P4-P6 and P7-P3-P8 in the sunY group I self-splicing intron.

Green R, Szostak JW
J Mol Biol. 1994;235(1):140-55 - PMID: 7507168

Chromosome length controls mitotic chromosome segregation in yeast.

Murray AW, Schultes NP, Szostak JW
Cell. 1986;45(4):529-36 - PMID: 3518944

Enzymatic activity of the conserved core of a group I self-splicing intron.

Szostak JW
Nature. 1986;322(6074):83-6 - PMID: 3014350 - DOI: 10.1038/322083a0

Pedigree analysis of plasmid segregation in yeast.

Murray AW, Szostak JW
Cell. 1983;34(3):961-70 - PMID: 6354471

An alternative pathway for meiotic chromosome segregation in yeast.

Dawson DS, Murray AW, Szostak JW
Science. 1986;234(4777):713-7 - PMID: 3535068

Cloning regulated yeast genes from a pool of lacZ fusions.

Ruby SW, Szostak JW, Murray AW
Methods Enzymol. 1983;101:253-69 - PMID: 6310328

Chromosome segregation in mitosis and meiosis.

Murray AW, Szostak JW
Annu Rev Cell Biol. 1987;1:289-315 - PMID: 3916318 - DOI: 10.1146/annurev.cb.01.110185.001445

Artificial chromosomes.

Murray AW, Szostak JW
Sci Am. 1987;257(5):62-8 - PMID: 3317814

DNA sequences of telomeres maintained in yeast.

Shampay J, Szostak JW, Blackburn EH
Nature. 1984;310(5973):154-7 - PMID: 6330571

The double-strand-break repair model for recombination.

Szostak JW, Orr-Weaver TL, Rothstein RJ, Stahl FW
Cell. 1983;33(1):25-35 - PMID: 6380756

Fungal recombination.

Orr-Weaver TL, Szostak JW
Microbiol Rev. 1985;49(1):33-58 - PMID: 3884994 - PMCID: PMC373016

Genetic applications of yeast transformation with linear and gapped plasmids.

Orr-Weaver TL, Szostak JW, Rothstein RJ
Methods Enzymol. 1983;101:228-45 - PMID: 6310326

RNA-peptide fusions for the in vitro selection of peptides and proteins.

Roberts RW, Szostak JW
Proc Natl Acad Sci U S A. 1997;94(23):12297-302 - PMID: 9356443 - PMCID: PMC24913

The ARD1 gene of yeast functions in the switch between the mitotic cell cycle and alternative developmental pathways.

Whiteway M, Szostak JW
Cell. 1985;43(2 Pt 1):483-92 - PMID: 3907857

Roles of the 2 microns gene products in stable maintenance of the 2 microns plasmid of Saccharomyces cerevisiae.

Reynolds AE, Murray AW, Szostak JW
Mol Cell Biol. 1987;7(10):3566-73 - PMID: 3316982 - PMCID: PMC368010

Isolation and characterization of fluorophore-binding RNA aptamers.

Holeman LA, Robinson SL, Szostak JW, Wilson C
Fold Des. 1999;3(6):423-31 - PMID: 9889155 - DOI: 10.1016/S1359-0278(98)00059-5

Isolation of a fluorophore-specific DNA aptamer with weak redox activity.

Wilson C, Szostak JW
Chem Biol. 1998;5(11):609-17 - PMID: 9831529

In vitro evolution of a self-alkylating ribozyme.

Wilson C, Szostak JW
Nature. 1995;374(6525):777-82 - PMID: 7723823 - DOI: 10.1038/374777a0

1H NMR studies of the high-affinity Rev binding site of the Rev responsive element of HIV-1 mRNA: base pairing in the core binding element.

Peterson RD, Bartel DP, Szostak JW, Horvath SJ, Feigon J
Biochemistry. 1994;33(18):5357-66 - PMID: 8180157

A DNA aptamer that binds adenosine and ATP.

Huizenga DE, Szostak JW
Biochemistry. 1995;34(2):656-65 - PMID: 7819261

Kinetic and thermodynamic characterization of the reaction catalyzed by a polynucleotide kinase ribozyme.

Lorsch JR, Szostak JW
Biochemistry. 1995;34(46):15315-27 - PMID: 7578148

The use of mRNA display to select high-affinity protein-binding peptides.

Wilson DS, Keefe AD, Szostak JW
Proc Natl Acad Sci U S A. 2001;98(7):3750-5 - PMID: 11274392 - PMCID: PMC31124 - DOI: 10.1073/pnas.061028198

Replication and resolution of telomeres in yeast.

Szostak JW
Cold Spring Harb Symp Quant Biol. 1983;47 Pt 2:1187-94 - PMID: 6305577

In vitro genetic analysis of the Tetrahymena self-splicing intron.

Green R, Ellington AD, Szostak JW
Nature. 1990;347(6291):406-8 - PMID: 2215650 - DOI: 10.1038/347406a0

Introduction: Combinatorial Chemistry.

Szostak JW
Chem Rev. 1997;97(2):347-348 - PMID: 11848873

In vitro selection of RNA molecules that bind specific ligands.

Ellington AD, Szostak JW
Nature. 1990;346(6287):818-22 - PMID: 1697402 - DOI: 10.1038/346818a0

Ribozyme-catalyzed primer extension by trinucleotides: a model for the RNA-catalyzed replication of RNA.

Doudna JA, Usman N, Szostak JW
Biochemistry. 1993;32(8):2111-5 - PMID: 7680575

DNA sequence of a mutation in the leader region of the yeast iso-1-cytochrome c mRNA.

Stiles JI, Szostak JW, Young AT, Wu R, Consaul S, Sherman F
Cell. 1981;25(1):277-84 - PMID: 6268305

Isolation of novel ribozymes that ligate AMP-activated RNA substrates.

Hager AJ, Szostak JW
Chem Biol. 1997;4(8):607-17 - PMID: 9281527

Evidence that the guanosine substrate of the Tetrahymena ribozyme is bound in the anti conformation and that N7 contributes to binding.

Lin CW, Hanna M, Szostak JW
Biochemistry. 1994;33(9):2703-7 - PMID: 8117735

Expanding the structural and functional diversity of RNA: analog uridine triphosphates as candidates for in vitro selection of nucleic acids.

Vaish NK, Fraley AW, Szostak JW, McLaughlin LW
Nucleic Acids Res. 2000;28(17):3316-22 - PMID: 10954600 - PMCID: PMC110695

Synthesis of RNA containing inosine: analysis of the sequence requirements for the 5' splice site of the Tetrahymena group I intron.

Green R, Szostak JW, Benner SA, Rich A, Usman N
Nucleic Acids Res. 1991;19(15):4161-6 - PMID: 1714564 - PMCID: PMC328556

Mutational analysis of conserved nucleotides in a self-splicing group I intron.

Couture S, Ellington AD, Gerber AS, Cherry JM, Doudna JA, Green R, Hanna M, Pace U, Rajagopal J, Szostak JW
J Mol Biol. 1990;215(3):345-58 - PMID: 1700131

Selection in vitro of single-stranded DNA molecules that fold into specific ligand-binding structures.

Ellington AD, Szostak JW
Nature. 1992;355(6363):850-2 - PMID: 1538766 - DOI: 10.1038/355850a0

Structural conventions for group I introns.

Burke JM, Belfort M, Cech TR, Davies RW, Schweyen RJ, Shub DA, Szostak JW, Tabak HF
Nucleic Acids Res. 1987;15(18):7217-21 - PMID: 3658691 - PMCID: PMC306243

Decreasing gradients of gene conversion on both sides of the initiation site for meiotic recombination at the ARG4 locus in yeast.

Schultes NP, Szostak JW
Genetics. 1990;126(4):813-22 - PMID: 1981763 - PMCID: PMC1204280

Constructing high complexity synthetic libraries of long ORFs using in vitro selection.

Cho G, Keefe AD, Liu R, Wilson DS, Szostak JW
J Mol Biol. 2000;297(2):309-19 - PMID: 10715203 - DOI: 10.1006/jmbi.2000.3571

Hybridization with synthetic oligonucleotides.

Szostak JW, Stiles JI, Tye BK, Chiu P, Sherman F, Wu R
Methods Enzymol. 1980;68:419-28 - PMID: 161605

Reverse transcriptase reads through a 2'-5'linkage and a 2'-thiophosphate in a template.

Lorsch JR, Bartel DP, Szostak JW
Nucleic Acids Res. 1995;23(15):2811-4 - PMID: 7544885 - PMCID: PMC307115

Phylogenetic and genetic evidence for base-triples in the catalytic domain of group I introns.

Michel F, Ellington AD, Couture S, Szostak JW
Nature. 1990;347(6293):578-80 - PMID: 2215683 - DOI: 10.1038/347578a0

Total chemical synthesis of a ribozyme derived from a group I intron.

Whoriskey SK, Usman N, Szostak JW
Proc Natl Acad Sci U S A. 1995;92(7):2465-9 - PMID: 7708666 - PMCID: PMC42238

RNA structure, not sequence, determines the 5' splice-site specificity of a group I intron.

Doudna JA, Cormack BP, Szostak JW
Proc Natl Acad Sci U S A. 1989;86(19):7402-6 - PMID: 2678103 - PMCID: PMC298070

Identification of healed terminal DNA fragments in linear minichromosomes of Schizosaccharomyces pombe.

Matsumoto T, Fukui K, Niwa O, Sugawara N, Szostak JW, Yanagida M
Mol Cell Biol. 1987;7(12):4424-30 - PMID: 2830493 - PMCID: PMC368126

A rapid procedure for the construction of linear yeast plasmids.

Szostak JW
Methods Enzymol. 1983;101:245-52 - PMID: 6310327

Replicating vesicles as models of primitive cell growth and division.

Hanczyc MM, Szostak JW
Curr Opin Chem Biol. 2004;8(6):660-4 - PMID: 15556412 - DOI: 10.1016/j.cbpa.2004.10.002

Genetic dissection of an RNA enzyme.

Doudna JA, Gerber AS, Cherry JM, Szostak JW
Cold Spring Harb Symp Quant Biol. 1988;52:173-80 - PMID: 2456876

Mutations in a semiconserved region of the Tetrahymena intron.

Pace U, Szostak JW
FEBS Lett. 1991;280(1):171-4 - PMID: 2009960

Suppression of mutations in the core of the Tetrahymena ribozyme by spermidine, ethanol and by substrate stabilization.

Hanna M, Szostak JW
Nucleic Acids Res. 1994;22(24):5326-31 - PMID: 7816622 - PMCID: PMC332078

Miniribozymes, small derivatives of the sunY intron, are catalytically active.

Doudna JA, Szostak JW
Mol Cell Biol. 1989;9(12):5480-3 - PMID: 2685567 - PMCID: PMC363717

Selection of a ribozyme that functions as a superior template in a self-copying reaction.

Green R, Szostak JW
Science. 1992;258(5090):1910-5 - PMID: 1470913

Telomerase: the beginning of the ends.

Szostak JW
Nature. 1989;337(6205):303-4 - PMID: 2765013 - DOI: 10.1038/337303a0

An initiation site for meiotic gene conversion in the yeast Saccharomyces cerevisiae.

Nicolas A, Treco D, Schultes NP, Szostak JW
Nature. 1989;338(6210):35-9 - PMID: 2537472 - DOI: 10.1038/338035a0

Double-strand breaks at an initiation site for meiotic gene conversion.

Sun H, Treco D, Schultes NP, Szostak JW
Nature. 1989;338(6210):87-90 - PMID: 2645528 - DOI: 10.1038/338087a0

Isolation of high-affinity GTP aptamers from partially structured RNA libraries.

Davis JH, Szostak JW
Proc Natl Acad Sci U S A. 2002;99(18):11616-21 - PMID: 12185247 - PMCID: PMC129318 - DOI: 10.1073/pnas.182095699

In vitro selection of functional nucleic acids.

Wilson DS, Szostak JW
Annu Rev Biochem. 2000;68:611-47 - PMID: 10872462 - DOI: 10.1146/annurev.biochem.68.1.611

In vitro selection and directed evolution.

Szostak JW
Harvey Lect. 2000;93:95-118 - PMID: 10941421

In vitro genetics.

Szostak JW
Trends Biochem Sci. 1992;17(3):89-93 - PMID: 1384177

Synthesizing life.

Szostak JW, Bartel DP, Luisi PL
Nature. 2001;409(6818):387-90 - PMID: 11201752 - DOI: 10.1038/35053176

Structurally complex and highly active RNA ligases derived from random RNA sequences.

Ekland EH, Szostak JW, Bartel DP
Science. 1995;269(5222):364-70 - PMID: 7618102

In vitro evolution suggests multiple origins for the hammerhead ribozyme.

Salehi-Ashtiani K, Szostak JW
Nature. 2001;414(6859):82-4 - PMID: 11689947 - DOI: 10.1038/35102081

Detection of heteroduplex DNA molecules among the products of Saccharomyces cerevisiae meiosis.

Lichten M, Goyon C, Schultes NP, Treco D, Szostak JW, Haber JE, Nicolas A
Proc Natl Acad Sci U S A. 1990;87(19):7653-7 - PMID: 2217196 - PMCID: PMC54806

Semipermeable lipid bilayers exhibit diastereoselectivity favoring ribose.

Sacerdote MG, Szostak JW
Proc Natl Acad Sci U S A. 2005;102(17):6004-8 - PMID: 15831588 - PMCID: PMC556129 - DOI: 10.1073/pnas.0408440102

Chance and necessity in the selection of nucleic acid catalysts.

Lorsch JR, Szostak JW
Acc Chem Res. 1996;29(2):103-10 - PMID: 11539421

In vitro evolution of new ribozymes with polynucleotide kinase activity.

Lorsch JR, Szostak JW
Nature. 1994;371(6492):31-6 - PMID: 7521014 - DOI: 10.1038/371031a0

Unusual metal ion catalysis in an acyl-transferase ribozyme.

Suga H, Cowan JA, Szostak JW
Biochemistry. 1998;37(28):10118-25 - PMID: 9665717 - DOI: 10.1021/bi980432a

Functional proteins from a random-sequence library.

Keefe AD, Szostak JW
Nature. 2001;410(6829):715-8 - PMID: 11287961 - PMCID: PMC4476321 - DOI: 10.1038/35070613

Recombination between sequences in nonhomologous positions.

Sugawara N, Szostak JW
Proc Natl Acad Sci U S A. 1983;80(18):5675-9 - PMID: 6351064 - PMCID: PMC384321

The yeast ARD1 gene product is required for repression of cryptic mating-type information at the HML locus.

Whiteway M, Freedman R, Van Arsdell S, Szostak JW, Thorner J
Mol Cell Biol. 1987;7(10):3713-22 - PMID: 3316986 - PMCID: PMC368027

A multisubunit ribozyme that is a catalyst of and template for complementary strand RNA synthesis.

Doudna JA, Couture S, Szostak JW
Science. 1991;251(5001):1605-8 - PMID: 1707185

Structural and kinetic characterization of an acyl transferase ribozyme.

Suga H, Lohse PA, Szostak JW
J Am Chem Soc. 1998;120(6):1151-6 - PMID: 11541113

In vitro selection of RNA aptamers against a composite small molecule-protein surface.

Plummer KA, Carothers JM, Yoshimura M, Szostak JW, Verdine GL
Nucleic Acids Res. 2005;33(17):5602-10 - PMID: 16199752 - PMCID: PMC1240114 - DOI: 10.1093/nar/gki867

A strategy for the generation of conditional mutations by protein destabilization.

Park EC, Finley D, Szostak JW
Proc Natl Acad Sci U S A. 1992;89(4):1249-52 - PMID: 1311090 - PMCID: PMC48426

Kinetic analysis of an efficient DNA-dependent TNA polymerase.

Horhota A, Zou K, Ichida JK, Yu B, McLaughlin LW, Szostak JW, Chaput JC
J Am Chem Soc. 2005;127(20):7427-34 - PMID: 15898792 - PMCID: PMC5042361 - DOI: 10.1021/ja0428255

An in vitro selection system for TNA.

Ichida JK, Zou K, Horhota A, Yu B, McLaughlin LW, Szostak JW
J Am Chem Soc. 2005;127(9):2802-3 - PMID: 15740086 - PMCID: PMC5072288 - DOI: 10.1021/ja045364w

A novel, modification-dependent ATP-binding aptamer selected from an RNA library incorporating a cationic functionality.

Vaish NK, Larralde R, Fraley AW, Szostak JW, McLaughlin LW
Biochemistry. 2003;42(29):8842-51 - PMID: 12873145 - DOI: 10.1021/bi027354i

Evolutionary optimization of a nonbiological ATP binding protein for improved folding stability.

Chaput JC, Szostak JW
Chem Biol. 2004;11(6):865-74 - PMID: 15217619 - DOI: 10.1016/j.chembiol.2004.04.006

DNA polymerase-mediated DNA synthesis on a TNA template.

Chaput JC, Ichida JK, Szostak JW
J Am Chem Soc. 2003;125(4):856-7 - PMID: 12537469 - DOI: 10.1021/ja028589k

Ribozyme-catalysed amino-acid transfer reactions.

Lohse PA, Szostak JW
Nature. 1996;381(6581):442-4 - PMID: 8632803 - DOI: 10.1038/381442a0

An RNA motif that binds ATP.

Sassanfar M, Szostak JW
Nature. 1993;364(6437):550-3 - PMID: 7687750 - DOI: 10.1038/364550a0

Kinetic and mechanistic analysis of nonenzymatic, template-directed oligoribonucleotide ligation.

Rohatgi R, Bartel DP, Szostak JW
J Am Chem Soc. 1996;118(14):3332-9 - PMID: 11539267

RNA catalysis in model protocell vesicles.

Chen IA, Salehi-Ashtiani K, Szostak JW
J Am Chem Soc. 2005;127(38):13213-9 - PMID: 16173749 - PMCID: PMC5072289 - DOI: 10.1021/ja051784p

Multiple, tandem plasmid integration in Saccharomyces cerevisiae.

Orr-Weaver TL, Szostak JW
Mol Cell Biol. 1983;3(4):747-9 - PMID: 6343844 - PMCID: PMC368590

The guanosine binding site of the Tetrahymena ribozyme.

Michel F, Hanna M, Green R, Bartel DP, Szostak JW
Nature. 1989;342(6248):391-5 - PMID: 2685606 - DOI: 10.1038/342391a0

Template-directed primer extension catalyzed by the Tetrahymena ribozyme.

Bartel DP, Doudna JA, Usman N, Szostak JW
Mol Cell Biol. 1991;11(6):3390-4 - PMID: 2038341 - PMCID: PMC360195

Isolation of a ribozyme with 5'-5' ligase activity.

Chapman KB, Szostak JW
Chem Biol. 1995;2(5):325-33 - PMID: 9383434

Specific Saccharomyces cerevisiae genes are expressed in response to DNA-damaging agents.

Ruby SW, Szostak JW
Mol Cell Biol. 1985;5(1):75-84 - PMID: 3920512 - PMCID: PMC366680

Identification of epitope-like consensus motifs using mRNA display.

Baggio R, Burgstaller P, Hale SP, Putney AR, Lane M, Lipovsek D, Wright MC, Roberts RW, Liu R, Szostak JW, Wagner RW
J Mol Recognit. 2002;15(3):126-34 - PMID: 12203838 - DOI: 10.1002/jmr.567

Construction and behavior of circularly permuted and telocentric chromosomes in Saccharomyces cerevisiae.

Murray AW, Szostak JW
Mol Cell Biol. 1986;6(9):3166-72 - PMID: 3537731 - PMCID: PMC367052

Evolution of aptamers with a new specificity and new secondary structures from an ATP aptamer.

Huang Z, Szostak JW
RNA. 2003;9(12):1456-63 - PMID: 14624002 - PMCID: PMC1370500

Meiotic recombination on artificial chromosomes in yeast.

Ross LO, Treco D, Nicolas A, Szostak JW, Dawson D
Genetics. 1992;131(3):541-50 - PMID: 1385793 - PMCID: PMC1205028

A DNA metalloenzyme with DNA ligase activity.

Cuenoud B, Szostak JW
Nature. 1995;375(6532):611-4 - PMID: 7791880 - DOI: 10.1038/375611a0

Scanning the human proteome for calmodulin-binding proteins.

Shen X, Valencia CA, Szostak JW, Szostak J, Dong B, Liu R
Proc Natl Acad Sci U S A. 2005;102(17):5969-74 - PMID: 15840729 - PMCID: PMC1087907 - DOI: 10.1073/pnas.0407928102

Ribozymes: aiming at RNA replication and protein synthesis.

Hager AJ, Pollard JD, Szostak JW
Chem Biol. 1996;3(9):717-25 - PMID: 8939686

Molecular biology: RNA gets a grip on translation.

Szostak JW
Nature. 2002;419(6910):890-1 - PMID: 12410294 - DOI: 10.1038/419890a

Unequal crossing over in the ribosomal DNA of Saccharomyces cerevisiae.

Szostak JW, Wu R
Nature. 1980;284(5755):426-30 - PMID: 6987539

One-step purification of recombinant proteins using a nanomolar-affinity streptavidin-binding peptide, the SBP-Tag.

Keefe AD, Wilson DS, Seelig B, Szostak JW
Protein Expr Purif. 2001;23(3):440-6 - PMID: 11722181 - DOI: 10.1006/prep.2001.1515

Functional information: Molecular messages.

Szostak JW
Nature. 2003;423(6941):689 - PMID: 12802312 - DOI: 10.1038/423689a

Is there left-handed DNA at the ends of yeast chromosomes?

Walmsley RM, Szostak JW, Petes TD
Nature. 1983;302(5903):84-6 - PMID: 6338397

Arabidopsis genome. A milestone in plant biology.

Ausubel FM
Plant Physiol. 2000;124(4):1451-4 - PMID: 11115856 - PMCID: PMC1539293

Pathogenesis of the human opportunistic pathogen Pseudomonas aeruginosa PA14 in Arabidopsis.

Plotnikova JM, Rahme LG, Ausubel FM
Plant Physiol. 2000;124(4):1766-74 - PMID: 11115892 - PMCID: PMC59873

A simple procedure for the analysis of single nucleotide polymorphisms facilitates map-based cloning in Arabidopsis.

Drenkard E, Richter BG, Rozen S, Stutius LM, Angell NA, Mindrinos M, Cho RJ, Oefner PJ, Davis RW, Ausubel FM
Plant Physiol. 2000;124(4):1483-92 - PMID: 11115864 - PMCID: PMC1539302

Use of cleaved amplified polymorphic sequences (CAPS) as genetic markers in Arabidopsis thaliana.

Glazebrook J, Drenkard E, Preuss D, Ausubel FM
Methods Mol Biol. 1998;82:173-82 - PMID: 9664424

The Enterococcus faecalis fsrB gene, a key component of the fsr quorum-sensing system, is associated with virulence in the rabbit endophthalmitis model.

Mylonakis E, Engelbert M, Qin X, Sifri CD, Murray BE, Ausubel FM, Gilmore MS, Calderwood SB
Infect Immun. 2002;70(8):4678-81 - PMID: 12117982 - PMCID: PMC128160

Use of Arabidopsis thaliana defense-related mutants to dissect the plant response to pathogens.

Ausubel FM, Katagiri F, Mindrinos M, Glazebrook J
Proc Natl Acad Sci U S A. 1995;92(10):4189-96 - PMID: 7753782 - PMCID: PMC41909

Cryptococcus neoformans Kin1 protein kinase homologue, identified through a Caenorhabditis elegans screen, promotes virulence in mammals.

Mylonakis E, Idnurm A, Moreno R, El Khoury J, Rottman JB, Ausubel FM, Heitman J, Calderwood SB
Mol Microbiol. 2004;54(2):407-19 - PMID: 15469513 - DOI: 10.1111/j.1365-2958.2004.04310.x

Arabidopsis thaliana PAD4 encodes a lipase-like gene that is important for salicylic acid signaling.

Jirage D, Tootle TL, Reuber TL, Frost LN, Feys BJ, Parker JE, Ausubel FM, Glazebrook J
Proc Natl Acad Sci U S A. 1999;96(23):13583-8 - PMID: 10557364 - PMCID: PMC23991

Differential mRNA display.

Reuber TL, Ausubel FM
Methods Cell Biol. 1996;49:431-40 - PMID: 8531774

Caenorhabditis elegans-based screen identifies Salmonella virulence factors required for conserved host-pathogen interactions.

Tenor JL, McCormick BA, Ausubel FM, Aballay A
Curr Biol. 2004;14(11):1018-24 - PMID: 15182677 - DOI: 10.1016/j.cub.2004.05.050

Salmonella typhimurium proliferates and establishes a persistent infection in the intestine of Caenorhabditis elegans.

Aballay A, Yorgey P, Ausubel FM
Curr Biol. 2000;10(23):1539-42 - PMID: 11114525

Structural studies of alfalfa roots infected with nodulation mutants of Rhizobium meliloti.

Hirsch AM, Long SR, Bang M, Haskins N, Ausubel FM
J Bacteriol. 1982;151(1):411-9 - PMID: 7085566 - PMCID: PMC220253

Construction of a broad host range cosmid cloning vector and its use in the genetic analysis of Rhizobium mutants.

Friedman AM, Long SR, Brown SE, Buikema WJ, Ausubel FM
Gene. 1982;18(3):289-96 - PMID: 6290332

Haplotypic divergence coupled with lack of diversity at the Arabidopsis thaliana alcohol dehydrogenase locus: roles for both balancing and directional selection?

Hanfstingl U, Berry A, Kellogg EA, Costa JT, Rüdiger W, Ausubel FM
Genetics. 1994;138(3):811-28 - PMID: 7851777 - PMCID: PMC1206230

Signals involved in Arabidopsis resistance to Trichoplusia ni caterpillars induced by virulent and avirulent strains of the phytopathogen Pseudomonas syringae.

Cui J, Jander G, Racki LR, Kim PD, Pierce NE, Ausubel FM
Plant Physiol. 2002;129(2):551-64 - PMID: 12068100 - PMCID: PMC161673 - DOI: 10.1104/pp.010815

The TASTY locus on chromosome 1 of Arabidopsis affects feeding of the insect herbivore Trichoplusia ni.

Jander G, Cui J, Nhan B, Pierce NE, Ausubel FM
Plant Physiol. 2001;126(2):890-8 - PMID: 11402216 - PMCID: PMC111178

An Arabidopsis thaliana lipoxygenase gene can be induced by pathogens, abscisic acid, and methyl jasmonate.

Melan MA, Dong X, Endara ME, Davis KR, Ausubel FM, Peterman TK
Plant Physiol. 1993;101(2):441-50 - PMID: 7506426 - PMCID: PMC160590

Use of cleaved amplified polymorphic sequences to distinguish strains of Staphylococcus epidermidis.

Calderwood SB, Baker MA, Carroll PA, Michel JL, Arbeit RD, Ausubel FM
J Clin Microbiol. 1996;34(11):2860-5 - PMID: 8897202 - PMCID: PMC229423

Plants and animals share functionally common bacterial virulence factors.

Rahme LG, Ausubel FM, Cao H, Drenkard E, Goumnerov BC, Lau GW, Mahajan-Miklos S, Plotnikova J, Tan MW, Tsongalis J, Walendziewicz CL, Tompkins RG
Proc Natl Acad Sci U S A. 2000;97(16):8815-21 - PMID: 10922040 - PMCID: PMC34017

Inactivation of the alpha C protein antigen gene, bca, by a novel shuttle/suicide vector results in attenuation of virulence and immunity in group B Streptococcus.

Li J, Kasper DL, Ausubel FM, Rosner B, Michel JL
Proc Natl Acad Sci U S A. 1997;94(24):13251-6 - PMID: 9371832 - PMCID: PMC24295

Challenge of Drosophila melanogaster with Cryptococcus neoformans and role of the innate immune response.

Apidianakis Y, Rahme LG, Heitman J, Ausubel FM, Calderwood SB, Mylonakis E
Eukaryot Cell. 2004;3(2):413-9 - PMID: 15075271 - PMCID: PMC387633

Contribution of gelatinase, serine protease, and fsr to the pathogenesis of Enterococcus faecalis endophthalmitis.

Engelbert M, Mylonakis E, Ausubel FM, Calderwood SB, Gilmore MS
Infect Immun. 2004;72(6):3628-33 - PMID: 15155673 - PMCID: PMC415677 - DOI: 10.1128/IAI.72.6.3628-3633.2004

Rhizobium meliloti 1021 has three differentially regulated loci involved in glutamine biosynthesis, none of which is essential for symbiotic nitrogen fixation.

de Bruijn FJ, Rossbach S, Schneider M, Ratet P, Messmer S, Szeto WW, Ausubel FM, Schell J
J Bacteriol. 1989;171(3):1673-82 - PMID: 2563998 - PMCID: PMC209797

Transcriptional regulation of the Arabidopsis thaliana chalcone synthase gene.

Feinbaum RL, Ausubel FM
Mol Cell Biol. 1988;8(5):1985-92 - PMID: 3386631 - PMCID: PMC363377

Mutational analysis of the Arabidopsis nucleotide binding site-leucine-rich repeat resistance gene RPS2.

Tao Y, Yuan F, Leister RT, Ausubel FM, Katagiri F
Plant Cell. 2000;12(12):2541-2554 - PMID: 11148296 - PMCID: PMC102236

Integration of Caenorhabditis elegans MAPK pathways mediating immunity and stress resistance by MEK-1 MAPK kinase and VHP-1 MAPK phosphatase.

Kim DH, Liberati NT, Mizuno T, Inoue H, Hisamoto N, Matsumoto K, Ausubel FM
Proc Natl Acad Sci U S A. 2004;101(30):10990-4 - PMID: 15256594 - PMCID: PMC503731 - DOI: 10.1073/pnas.0403546101

Isolation of new Arabidopsis mutants with enhanced disease susceptibility to Pseudomonas syringae by direct screening.

Volko SM, Boller T, Ausubel FM
Genetics. 1998;149(2):537-48 - PMID: 9611172 - PMCID: PMC1460196

Construction of an Enterococcus faecalis Tn917-mediated-gene-disruption library offers insight into Tn917 insertion patterns.

Garsin DA, Urbach J, Huguet-Tapia JC, Peters JE, Ausubel FM
J Bacteriol. 2004;186(21):7280-9 - PMID: 15489440 - PMCID: PMC523214 - DOI: 10.1128/JB.186.21.7280-7289.2004

Staphylococcus aureus virulence factors identified by using a high-throughput Caenorhabditis elegans-killing model.

Begun J, Sifri CD, Goldman S, Calderwood SB, Ausubel FM
Infect Immun. 2005;73(2):872-7 - PMID: 15664928 - PMCID: PMC547013 - DOI: 10.1128/IAI.73.2.872-877.2005

General method for site-directed mutagenesis in Escherichia coli O18ac:K1:H7: deletion of the inducible superoxide dismutase gene, sodA, does not diminish bacteremia in neonatal rats.

Bloch CA, Thorne GM, Ausubel FM
Infect Immun. 1989;57(7):2141-8 - PMID: 2543632 - PMCID: PMC313853

The genetic engineering of nitrogen fixation.

Earl CD, Ausubel FM
Nutr Rev. 1983;41(1):1-6 - PMID: 6302610

Rhizobium meliloti nodD genes mediate host-specific activation of nodABC.

Honma MA, Asomaning M, Ausubel FM
J Bacteriol. 1990;172(2):901-11 - PMID: 2298703 - PMCID: PMC208518

Polymorphic amplified typing sequences provide a novel approach to Escherichia coli O157:H7 strain typing.

Kudva IT, Evans PS, Perna NT, Barrett TJ, DeCastro GJ, Ausubel FM, Blattner FR, Calderwood SB
J Clin Microbiol. 2002;40(4):1152-9 - PMID: 11923324 - PMCID: PMC140341

Killing of Caenorhabditis elegans by Cryptococcus neoformans as a model of yeast pathogenesis.

Mylonakis E, Ausubel FM, Perfect JR, Heitman J, Calderwood SB
Proc Natl Acad Sci U S A. 2002;99(24):15675-80 - PMID: 12438649 - PMCID: PMC137775 - DOI: 10.1073/pnas.232568599

The epidemiology of resistance to ofloxacin and oxacillin among clinical coagulase-negative staphylococcal isolates: analysis of risk factors and strain types.

Pegues DA, Colby C, Hibberd PL, Cohen LG, Ausubel FM, Calderwood SB, Hooper DC
Clin Infect Dis. 1998;26(1):72-9 - PMID: 9455512

The central domain of Rhizobium meliloti NifA is sufficient to activate transcription from the R. meliloti nifH promoter.

Huala E, Ausubel FM
J Bacteriol. 1989;171(6):3354-65 - PMID: 2722751 - PMCID: PMC210058

Nitrogen fixation by Klebsiella pneumoniae is inhibited by certain multicopy hybrid nif plasmids.

Riedel GE, Brown SE, Ausubel FM
J Bacteriol. 1983;153(1):45-56 - PMID: 6336738 - PMCID: PMC217340

Cloned alpha and beta C-protein antigens of group B streptococci elicit protective immunity.

Michel JL, Madoff LC, Kling DE, Kasper DL, Ausubel FM
Infect Immun. 1991;59(6):2023-8 - PMID: 1674738 - PMCID: PMC257960

Prokaryotic signal transduction mediated by sensor and regulator protein pairs.

Albright LM, Huala E, Ausubel FM
Annu Rev Genet. 1990;23:311-36 - PMID: 2694934 - DOI: 10.1146/annurev.ge.23.120189.001523

A high-throughput, near-saturating screen for type III effector genes from Pseudomonas syringae.

Chang JH, Urbach JM, Law TF, Arnold LW, Hu A, Gombar S, Grant SR, Ausubel FM, Dangl JL
Proc Natl Acad Sci U S A. 2005;102(7):2549-54 - PMID: 15701698 - PMCID: PMC549004 - DOI: 10.1073/pnas.0409660102

Conserved domains in bacterial regulatory proteins that respond to environmental stimuli.

Ronson CW, Nixon BT, Ausubel FM
Cell. 1987;49(5):579-81 - PMID: 3555840

Identification of a gene linked to Rhizobium meliloti ntrA whose product is homologous to a family to ATP-binding proteins.

Albright LM, Ronson CW, Nixon BT, Ausubel FM
J Bacteriol. 1989;171(4):1932-41 - PMID: 2703463 - PMCID: PMC209842

Rhizobium meliloti has three functional copies of the nodD symbiotic regulatory gene.

Honma MA, Ausubel FM
Proc Natl Acad Sci U S A. 1987;84(23):8558-62 - PMID: 3479806 - PMCID: PMC299584

The central domain of Rhizobium leguminosarum DctD functions independently to activate transcription.

Huala E, Stigter J, Ausubel FM
J Bacteriol. 1992;174(4):1428-31 - PMID: 1735730 - PMCID: PMC206444

Virulence of the phytopathogen Pseudomonas syringae pv. maculicola is rpoN dependent.

Hendrickson EL, Guevera P, Peñaloza-Vàzquez A, Shao J, Bender C, Ausubel FM
J Bacteriol. 2000;182(12):3498-507 - PMID: 10852883 - PMCID: PMC101941

Deduced products of C4-dicarboxylate transport regulatory genes of Rhizobium leguminosarum are homologous to nitrogen regulatory gene products.

Ronson CW, Astwood PM, Nixon BT, Ausubel FM
Nucleic Acids Res. 1987;15(19):7921-34 - PMID: 3671068 - PMCID: PMC306317

Virulence effect of Enterococcus faecalis protease genes and the quorum-sensing locus fsr in Caenorhabditis elegans and mice.

Sifri CD, Mylonakis E, Singh KV, Qin X, Garsin DA, Murray BE, Ausubel FM, Calderwood SB
Infect Immun. 2002;70(10):5647-50 - PMID: 12228293 - PMCID: PMC128331

Expression of nodule-specific genes in alfalfa root nodules blocked at an early stage of development.

Dickstein R, Bisseling T, Reinhold VN, Ausubel FM
Genes Dev. 1988;2(6):677-87 - PMID: 3417147

Are innate immune signaling pathways in plants and animals conserved?

Ausubel FM
Nat Immunol. 2005;6(10):973-9 - PMID: 16177805 - DOI: 10.1038/ni1253

The alternative sigma factor RpoN is required for hrp activity in Pseudomonas syringae pv. maculicola and acts at the level of hrpL transcription.

Hendrickson EL, Guevera P, Ausubel FM
J Bacteriol. 2000;182(12):3508-16 - PMID: 10852884 - PMCID: PMC101944

A dual-labeling method for identifying differentially expressed genes: use in the identification of cDNA clones that hybridize to RNAs whose abundance in tomato flowers is potentially regulated by gibberellins.

Olszewski NE, Gast RT, Ausubel FM
Gene. 1989;77(1):155-62 - PMID: 2663653

Nodules elicited by Rhizobium meliloti heme mutants are arrested at an early stage of development.

Dickstein R, Scheirer DC, Fowle WH, Ausubel FM
Mol Gen Genet. 1991;230(3):423-32 - PMID: 1766439

Mutations affecting regulation of the Klebsiella pneumoniae nifH (nitrogenase reductase) promotor.

Brown SE, Ausubel FM
J Bacteriol. 1984;157(1):143-7 - PMID: 6360993 - PMCID: PMC215143

Molecular recognition of pathogen attack occurs inside of plant cells in plant disease resistance specified by the Arabidopsis genes RPS2 and RPM1.

Leister RT, Ausubel FM, Katagiri F
Proc Natl Acad Sci U S A. 1996;93(26):15497-502 - PMID: 8986840 - PMCID: PMC26433

Construction of a correlated physical and genetic map of the Klebsiella pneumoniae hisDGO region using transposon Tn5 mutagenesis.

de Bruijn FJ, Stroke IL, Marvel DJ, Ausubel FM
EMBO J. 1984;2(10):1831-8 - PMID: 6315405 - PMCID: PMC555367

The cloning and transposon Tn5 mutagenesis of the glnA region of Klebsiella pneumoniae: identification of glnR, a gene involved in the regulation of the nif and hut operons.

de Bruijn FJ, Ausubel FM
Mol Gen Genet. 1982;183(2):289-97 - PMID: 6120440

Paraquat-mediated selection for mutations in the manganese-superoxide dismutase gene sodA.

Bloch CA, Ausubel FM
J Bacteriol. 1986;168(2):795-8 - PMID: 3023287 - PMCID: PMC213554

Genetic and structural analysis of the Rhizobium meliloti fixA, fixB, fixC, and fixX genes.

Earl CD, Ronson CW, Ausubel FM
J Bacteriol. 1987;169(3):1127-36 - PMID: 3029021 - PMCID: PMC211910

Use of Arabidopsis for genetic dissection of plant defense responses.

Glazebrook J, Rogers EE, Ausubel FM
Annu Rev Genet. 1998;31:547-69 - PMID: 9442907 - DOI: 10.1146/annurev.genet.31.1.547

Simulation of fungal-mediated cell death by fumonisin B1 and selection of fumonisin B1-resistant (fbr) Arabidopsis mutants.

Stone JM, Heard JE, Asai T, Ausubel FM
Plant Cell. 2000;12(10):1811-22 - PMID: 11041878 - PMCID: PMC149121

Isolation of Arabidopsis genes that differentiate between resistance responses mediated by the RPS2 and RPM1 disease resistance genes.

Reuber TL, Ausubel FM
Plant Cell. 1996;8(2):241-9 - PMID: 8742710 - PMCID: PMC161094 - DOI: 10.1105/tpc.8.2.241

Analysis of Arabidopsis mutants deficient in flavonoid biosynthesis.

Shirley BW, Kubasek WL, Storz G, Bruggemann E, Koornneef M, Ausubel FM, Goodman HM
Plant J. 1995;8(5):659-71 - PMID: 8528278

Arabidopsis mutants compromised for the control of cellular damage during pathogenesis and aging.

Greenberg JT, Ausubel FM
Plant J. 1993;4(2):327-41 - PMID: 8220484

A light-independent developmental mechanism potentiates flavonoid gene expression in Arabidopsis seedlings.

Kubasek WL, Ausubel FM, Shirley BW
Plant Mol Biol. 1998;37(2):217-23 - PMID: 9617795

Modulation of expression of the ToxR regulon in Vibrio cholerae by a member of the two-component family of response regulators.

Wong SM, Carroll PA, Rahme LG, Ausubel FM, Calderwood SB
Infect Immun. 1998;66(12):5854-61 - PMID: 9826365 - PMCID: PMC108741

Isolation and characterization of disease resistance gene homologues from rice cultivar IR64.

Ilag LL, Yadav RC, Huang N, Ronald PC, Ausubel FM
Gene. 2000;255(2):245-55 - PMID: 11024284

Molecular characterization of Tn5-induced symbiotic (Fix-) mutants of Rhizobium meliloti.

Zimmerman JL, Szeto WW, Ausubel FM
J Bacteriol. 1983;156(3):1025-34 - PMID: 6196347 - PMCID: PMC217946

Mediation of pathogen resistance by exudation of antimicrobials from roots.

Bais HP, Prithiviraj B, Jha AK, Ausubel FM, Vivanco JM
Nature. 2005;434(7030):217-21 - PMID: 15759001 - DOI: 10.1038/nature03356

Three unique mutants of Arabidopsis identify eds loci required for limiting growth of a biotrophic fungal pathogen.

Dewdney J, Reuber TL, Wildermuth MC, Devoto A, Cui J, Stutius LM, Drummond EP, Ausubel FM
Plant J. 2000;24(2):205-18 - PMID: 11069695

Regulation of nitrogen fixation genes.

Gussin GN, Ronson CW, Ausubel FM
Annu Rev Genet. 1987;20:567-91 - PMID: 3545064 - DOI: 10.1146/annurev.ge.20.120186.003031

Rhizobium meliloti nodulation genes allow Agrobacterium tumefaciens and Escherichia coli to form pseudonodules on alfalfa.

Hirsch AM, Wilson KJ, Jones JD, Bang M, Walker VV, Ausubel FM
J Bacteriol. 1984;158(3):1133-43 - PMID: 6327629 - PMCID: PMC215561

Evolutionary perspectives on innate immunity from the study of Caenorhabditis elegans.

Kim DH, Ausubel FM
Curr Opin Immunol. 2005;17(1):4-10 - PMID: 15653303 - DOI: 10.1016/j.coi.2004.11.007

Roles of salicylic acid, jasmonic acid, and ethylene in cpr-induced resistance in arabidopsis.

Clarke JD, Volko SM, Ledford H, Ausubel FM, Dong X
Plant Cell. 2000;12(11):2175-90 - PMID: 11090217 - PMCID: PMC150166

Pseudomonas syringae manipulates systemic plant defenses against pathogens and herbivores.

Cui J, Bahrami AK, Pringle EG, Hernandez-Guzman G, Bender CL, Pierce NE, Ausubel FM
Proc Natl Acad Sci U S A. 2005;102(5):1791-6 - PMID: 15657122 - PMCID: PMC547856 - DOI: 10.1073/pnas.0409450102

Physical and genetic characterization of Rhizobium meliloti symbiotic mutants.

Buikema WJ, Long SR, Brown SE, van den Bos RC, Earl C, Ausubel FM
J Mol Appl Genet. 1984;2(3):249-60 - PMID: 6363587

Hypersusceptibility of cystic fibrosis mice to chronic Pseudomonas aeruginosa oropharyngeal colonization and lung infection.

Coleman FT, Mueschenborn S, Meluleni G, Ray C, Carey VJ, Vargas SO, Cannon CL, Ausubel FM, Pier GB
Proc Natl Acad Sci U S A. 2003;100(4):1949-54 - PMID: 12578988 - PMCID: PMC149939 - DOI: 10.1073/pnas.0437901100

Tandemly duplicated Arabidopsis genes that encode polygalacturonase-inhibiting proteins are regulated coordinately by different signal transduction pathways in response to fungal infection.

Ferrari S, Vairo D, Ausubel FM, Cervone F, De Lorenzo G
Plant Cell. 2003;15(1):93-106 - PMID: 12509524 - PMCID: PMC143454

Genome-wide mapping with biallelic markers in Arabidopsis thaliana.

Cho RJ, Mindrinos M, Richards DR, Sapolsky RJ, Anderson M, Drenkard E, Dewdney J, Reuber TL, Stammers M, Federspiel N, Theologis A, Yang WH, Hubbell E, Au M, Chung EY, Lashkari D, Lemieux B, Dean C, Lipshutz RJ, Ausubel FM, Davis RW, Oefner PJ
Nat Genet. 1999;23(2):203-7 - PMID: 10508518 - DOI: 10.1038/13833

Isolation and characterization of symbiotic mutants of bradyrhizobium sp. (Arachis) strain NC92: mutants with host-specific defects in nodulation and nitrogen fixation.

Wilson KJ, Anjaiah V, Nambiar PT, Ausubel FM
J Bacteriol. 1987;169(5):2177-86 - PMID: 3032910 - PMCID: PMC212124

RESISTANCE TO FUSARIUM OXYSPORUM 1, a dominant Arabidopsis disease-resistance gene, is not race specific.

Diener AC, Ausubel FM
Genetics. 2005;171(1):305-21 - PMID: 15965251 - PMCID: PMC1456520 - DOI: 10.1534/genetics.105.042218

Galleria mellonella as a model system to study Cryptococcus neoformans pathogenesis.

Mylonakis E, Moreno R, El Khoury JB, Idnurm A, Heitman J, Calderwood SB, Ausubel FM, Diener A
Infect Immun. 2005;73(7):3842-50 - PMID: 15972469 - PMCID: PMC1168598 - DOI: 10.1128/IAI.73.7.3842-3850.2005

Strains of Escherichia coli O157:H7 differ primarily by insertions or deletions, not single-nucleotide polymorphisms.

Kudva IT, Evans PS, Perna NT, Barrett TJ, Ausubel FM, Blattner FR, Calderwood SB
J Bacteriol. 2002;184(7):1873-9 - PMID: 11889093 - PMCID: PMC134921

Nitrogen fixation specific regulatory genes of Klebsiella pneumoniae and Rhizobium meliloti share homology with the general nitrogen regulatory gene ntrC of K. pneumoniae.

Buikema WJ, Szeto WW, Lemley PV, Orme-Johnson WH, Ausubel FM
Nucleic Acids Res. 1985;13(12):4539-55 - PMID: 2989799 - PMCID: PMC321805

Regulation of nitrogen fixation genes.

Ausubel FM
Cell. 1984;37(1):5-6 - PMID: 6373013

Nucleotide sequence of the gene coding for the nitrogenase iron protein from Klebsiella pneumoniae.

Sundaresan V, Ausubel FM
J Biol Chem. 1981;256(6):2808-12 - PMID: 6259144

Overlapping sequences of Klebsiella pneumoniae nifDNA cloned and characterized.

Cannon FC, Riedel GE, Ausubel FM
Mol Gen Genet. 1979;174(1):59-66 - PMID: 384162

Recombinant P4 bacteriophages propagate as viable lytic phages or as autonomous plasmids in Klebsiella pneumoniae.

Ow DW, Ausubel FM
Mol Gen Genet. 1981;180(1):165-75 - PMID: 6255293

Ultrastructural analysis of ineffective alfalfa nodules formed by nif::Tn5 mutants of Rhizobium meliloti.

Hirsch AM, Bang M, Ausubel FM
J Bacteriol. 1983;155(1):367-80 - PMID: 6575011 - PMCID: PMC217689

Glutamine synthetase mutations which affect expression of nitrogen fixation genes in Klebsiella pneumoniae.

Ausubel FM, Bird SC, Durbin KJ, Janssen KA, Margolskee RF, Peskin AP
J Bacteriol. 1979;140(2):597-606 - PMID: 40960 - PMCID: PMC216687

High intensity and blue light regulated expression of chimeric chalcone synthase genes in transgenic Arabidopsis thaliana plants.

Feinbaum RL, Storz G, Ausubel FM
Mol Gen Genet. 1991;226(3):449-56 - PMID: 2038307

Developmental regulation of nodule-specific genes in alfalfa root nodules.

Dunn K, Dickstein R, Feinbaum R, Burnett BK, Peterman TK, Thoidis G, Goodman HM, Ausubel FM
Mol Plant Microbe Interact. 1988;1(2):66-74 - PMID: 2908768

Symbiotic nitrogen fixation: developmental genetics of nodule formation.

Lang-Unnasch N, Dunn K, Ausubel FM
Cold Spring Harb Symp Quant Biol. 1986;50:555-63 - PMID: 3868494

The worm has turned--microbial virulence modeled in Caenorhabditis elegans.

Sifri CD, Begun J, Ausubel FM
Trends Microbiol. 2005;13(3):119-27 - PMID: 15737730 - DOI: 10.1016/j.tim.2005.01.003

Caenorhabditis elegans: a model genetic host to study Pseudomonas aeruginosa pathogenesis.

Tan MW, Ausubel FM
Curr Opin Microbiol. 2000;3(1):29-34 - PMID: 10679415

The roles of mucD and alginate in the virulence of Pseudomonas aeruginosa in plants, nematodes and mice.

Yorgey P, Rahme LG, Tan MW, Ausubel FM
Mol Microbiol. 2001;41(5):1063-76 - PMID: 11555287

Large, identical, tandem repeating units in the C protein alpha antigen gene, bca, of group B streptococci.

Michel JL, Madoff LC, Olson K, Kling DE, Kasper DL, Ausubel FM
Proc Natl Acad Sci U S A. 1992;89(21):10060-4 - PMID: 1438195 - PMCID: PMC50277

Molecular genetic analysis of Klebsiella pneumoniae nitrogen-fixation (nif) genes.

Ausubel FM, Cannon FC
Cold Spring Harb Symp Quant Biol. 1981;45 Pt 2:487-99 - PMID: 6266743

Caenorhabditis elegans as a host for the study of host-pathogen interactions.

Aballay A, Ausubel FM
Curr Opin Microbiol. 2002;5(1):97-101 - PMID: 11834377

Mode of action of the Arabidopsis thaliana phytoalexin camalexin and its role in Arabidopsis-pathogen interactions.

Rogers EE, Glazebrook J, Ausubel FM
Mol Plant Microbe Interact. 1996;9(8):748-57 - PMID: 8870273

Differential induction of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase genes in Arabidopsis thaliana by wounding and pathogenic attack.

Keith B, Dong XN, Ausubel FM, Fink GR
Proc Natl Acad Sci U S A. 1991;88(19):8821-5 - PMID: 1681544 - PMCID: PMC52602

Conservation of nodulation genes between Rhizobium meliloti and a slow-growing Rhizobium strain that nodulates a nonlegume host.

Marvel DJ, Kuldau G, Hirsch A, Richards E, Torrey JG, Ausubel FM
Proc Natl Acad Sci U S A. 1985;82(17):5841-5 - PMID: 16593600 - PMCID: PMC390649

Caenorhabditis elegans as a model host for Staphylococcus aureus pathogenesis.

Sifri CD, Begun J, Ausubel FM, Calderwood SB
Infect Immun. 2003;71(4):2208-17 - PMID: 12654843 - PMCID: PMC152095

Use of the Galleria mellonella caterpillar as a model host to study the role of the type III secretion system in Pseudomonas aeruginosa pathogenesis.

Miyata S, Casey M, Frank DW, Ausubel FM, Drenkard E
Infect Immun. 2003;71(5):2404-13 - PMID: 12704110 - PMCID: PMC153283

Conservation of structure and location of Rhizobium meliloti and Klebsiella pneumoniae nifB genes.

Buikema WJ, Klingensmith JA, Gibbons SL, Ausubel FM
J Bacteriol. 1987;169(3):1120-6 - PMID: 3029020 - PMCID: PMC211909

Aerobic inactivation of Rhizobium meliloti NifA in Escherichia coli is mediated by lon and two newly identified genes, snoB and snoC.

Huala E, Moon AL, Ausubel FM
J Bacteriol. 1991;173(1):382-90 - PMID: 1846139 - PMCID: PMC207197

Cytotoxicity of hydrogen peroxide produced by Enterococcus faecium.

Moy TI, Mylonakis E, Calderwood SB, Ausubel FM
Infect Immun. 2004;72(8):4512-20 - PMID: 15271910 - PMCID: PMC470665 - DOI: 10.1128/IAI.72.8.4512-4520.2004

Elucidating the molecular mechanisms of bacterial virulence using non-mammalian hosts.

Mahajan-Miklos S, Rahme LG, Ausubel FM
Mol Microbiol. 2000;37(5):981-8 - PMID: 10972817

Pseudomonas aeruginosa killing of Caenorhabditis elegans used to identify P. aeruginosa virulence factors.

Tan MW, Rahme LG, Sternberg JA, Tompkins RG, Ausubel FM
Proc Natl Acad Sci U S A. 1999;96(5):2408-13 - PMID: 10051655 - PMCID: PMC26797

Positive correlation between virulence of Pseudomonas aeruginosa mutants in mice and insects.

Jander G, Rahme LG, Ausubel FM
J Bacteriol. 2000;182(13):3843-5 - PMID: 10851003 - PMCID: PMC94559

VPEgamma exhibits a caspase-like activity that contributes to defense against pathogens.

Rojo E, Martín R, Carter C, Zouhar J, Pan S, Plotnikova J, Jin H, Paneque M, Sánchez-Serrano JJ, Baker B, Ausubel FM, Raikhel NV
Curr Biol. 2004;14(21):1897-906 - PMID: 15530390 - DOI: 10.1016/j.cub.2004.09.056

Identification of virulence genes in a pathogenic strain of Pseudomonas aeruginosa by representational difference analysis.

Choi JY, Sifri CD, Goumnerov BC, Rahme LG, Ausubel FM, Calderwood SB
J Bacteriol. 2002;184(4):952-61 - PMID: 11807055 - PMCID: PMC134824

Molecular genetics of plant disease resistance.

Staskawicz BJ, Ausubel FM, Baker BJ, Ellis JG, Jones JD
Science. 1995;268(5211):661-7 - PMID: 7732374

The Caenorhabditis elegans MAPK phosphatase VHP-1 mediates a novel JNK-like signaling pathway in stress response.

Mizuno T, Hisamoto N, Terada T, Kondo T, Adachi M, Nishida E, Kim DH, Ausubel FM, Matsumoto K
EMBO J. 2004;23(11):2226-34 - PMID: 15116070 - PMCID: PMC419906 - DOI: 10.1038/sj.emboj.7600226

Conditionally replicating plasmid vectors that can integrate into the Klebsiella pneumoniae chromosome via bacteriophage P4 site-specific recombination.

Ow DW, Ausubel FM
J Bacteriol. 1983;155(2):704-13 - PMID: 6307977 - PMCID: PMC217740

The art of serendipity: killing of Caenorhabditis elegans by human pathogens as a model of bacterial and fungal pathogenesis.

Mylonakis E, Ausubel FM, Tang RJ, Calderwood SB
Expert Rev Anti Infect Ther. 2003;1(1):167-73 - PMID: 15482109

Differential roles of the Pseudomonas aeruginosa PA14 rpoN gene in pathogenicity in plants, nematodes, insects, and mice.

Hendrickson EL, Plotnikova J, Mahajan-Miklos S, Rahme LG, Ausubel FM
J Bacteriol. 2001;183(24):7126-34 - PMID: 11717271 - PMCID: PMC95561 - DOI: 10.1128/JB.183.24.7126-7134.2001

The centromere region of Arabidopsis thaliana chromosome 1 contains telomere-similar sequences.

Richards EJ, Goodman HM, Ausubel FM
Nucleic Acids Res. 1991;19(12):3351-7 - PMID: 1648204 - PMCID: PMC328334

Specialized binary vector for plant transformation: expression of the Arabidopsis thaliana AHAS gene in Nicotiana tabacum.

Olszewski NE, Martin FB, Ausubel FM
Nucleic Acids Res. 1988;16(22):10765-82 - PMID: 3060849 - PMCID: PMC338938

Five components of the ethylene-response pathway identified in a screen for weak ethylene-insensitive mutants in Arabidopsis.

Alonso JM, Stepanova AN, Solano R, Wisman E, Ferrari S, Ausubel FM, Ecker JR
Proc Natl Acad Sci U S A. 2003;100(5):2992-7 - PMID: 12606727 - PMCID: PMC151454 - DOI: 10.1073/pnas.0438070100

Regulation of Flavonoid Biosynthetic Genes in Germinating Arabidopsis Seedlings.

Kubasek WL, Shirley BW, McKillop A, Goodman HM, Briggs W, Ausubel FM
Plant Cell. 1992;4(10):1229-1236 - PMID: 12297632 - PMCID: PMC160210 - DOI: 10.1105/tpc.4.10.1229

Identification and characterization of the Rhizobium meliloti ntrC gene: R. meliloti has separate regulatory pathways for activation of nitrogen fixation genes in free-living and symbiotic cells.

Szeto WW, Nixon BT, Ronson CW, Ausubel FM
J Bacteriol. 1987;169(4):1423-32 - PMID: 2881918 - PMCID: PMC211963

Interference between Rhizobium meliloti and Rhizobium trifolii nodulation genes: genetic basis of R. meliloti dominance.

Debellé F, Maillet F, Vasse J, Rosenberg C, de Billy F, Truchet G, Dénarié J, Ausubel FM
J Bacteriol. 1988;170(12):5718-27 - PMID: 2848012 - PMCID: PMC211674

Rhizobium meliloti ntrA (rpoN) gene is required for diverse metabolic functions.

Ronson CW, Nixon BT, Albright LM, Ausubel FM
J Bacteriol. 1987;169(6):2424-31 - PMID: 3034856 - PMCID: PMC212082

A superfamily of Arabidopsis thaliana retrotransposons.

Konieczny A, Voytas DF, Cummings MP, Ausubel FM
Genetics. 1991;127(4):801-9 - PMID: 1709409 - PMCID: PMC1204407

Signal transduction mutants of Arabidopsis uncouple nuclear CAB and RBCS gene expression from chloroplast development.

Susek RE, Ausubel FM, Chory J
Cell. 1993;74(5):787-99 - PMID: 7690685

Molecular genetics of symbiotic nitrogen fixation.

Ausubel FM
Cell. 1982;29(1):1-2 - PMID: 6286135

Biological nitrogen fixation: recent advances and future prospects.

Ausubel FM
Regul Toxicol Pharmacol. 1986;6(1):1-10 - PMID: 3704206

Directive segregation in the basis of colE1 plasmid incompatibility.

Bedbrook JR, Lehrach H, Ausubel FM
Nature. 1979;281(5731):447-52 - PMID: 386132

Cyanobacterial ribonucleic acid polymerases recognize lambda promoters.

Miller SS, Ausubel FM, Bogorad L
J Bacteriol. 1979;140(1):246-50 - PMID: 159286 - PMCID: PMC216802

Radiochemical identification of the kil gene product of bacteriophage lambda.

Greer H, Ausubel FM
Virology. 1979;95(2):577-80 - PMID: 462802

Recombination between bacterial plasmids leading to the formation of plasmid multimers.

Bedbrook JR, Ausubel FM
Cell. 1976;9(4 PT 2):707-16 - PMID: 797459

Radiochemical purification of bacteriophage lambda integrase.

Ausubel FM
Nature. 1974;247(437):152-4 - PMID: 4589454

Long-term outcome of children surviving massive burns.

Sheridan RL, Hinson MI, Liang MH, Nackel AF, Schoenfeld DA, Ryan CM, Mulligan JL, Tompkins RG
JAMA. 2000;283(1):69-73 - PMID: 10632282

Significance analysis of time course microarray experiments.

Storey JD, Xiao W, Leek JT, Tompkins RG, Davis RW
Proc Natl Acad Sci U S A. 2005;102(36):12837-42 - PMID: 16141318 - PMCID: PMC1201697 - DOI: 10.1073/pnas.0504609102

Cellular distribution of endotoxin after injection of chemically purified lipopolysaccharide differs from that after injection of live bacteria.

Ge Y, Ezzell RM, Tompkins RG, Warren HS
J Infect Dis. 1994;169(1):95-104 - PMID: 8277203

Long-term maintenance of cytochrome P450 activities by rat hepatocyte/3T3 cell co-cultures in heparinized human plasma.

Washizu J, Berthiaume F, Mokuno Y, Tompkins RG, Toner M, Yarmush ML
Tissue Eng. 2001;7(6):691-703 - PMID: 11749727 - DOI: 10.1089/107632701753337654

Comparative proteome analyses of human plasma following in vivo lipopolysaccharide administration using multidimensional separations coupled with tandem mass spectrometry.

Qian WJ, Jacobs JM, Camp DG, Monroe ME, Moore RJ, Gritsenko MA, Calvano SE, Lowry SF, Xiao W, Moldawer LL, Davis RW, Tompkins RG, Smith RD
Proteomics. 2005;5(2):572-84 - PMID: 15627965 - PMCID: PMC1781926 - DOI: 10.1002/pmic.200400942

Effect of collagen gel configuration on the cytoskeleton in cultured rat hepatocytes.

Ezzell RM, Toner M, Hendricks K, Dunn JC, Tompkins RG, Yarmush ML
Exp Cell Res. 1993;208(2):442-52 - PMID: 8375473 - DOI: 10.1006/excr.1993.1266

A stable long-term hepatocyte culture system for studies of physiologic processes: cytokine stimulation of the acute phase response in rat and human hepatocytes.

Bader A, Borel Rinkes IH, Closs EI, Ryan CM, Toner M, Cunningham JM, Tompkins RG, Yarmush ML
Biotechnol Prog. 1992;8(3):219-25 - PMID: 1368259 - DOI: 10.1021/bp00015a007

In vivo rabbit hindquarter model for assessment of regional burn hypermetabolism.

Xu J, Fei Z, Yu YM, Xu W, Rhodes A, Tompkins RG, Schulz JT
J Appl Physiol. 2002;94(1):135-40 - PMID: 12391055 - DOI: 10.1152/japplphysiol.00513.2002

Clinical experience with the use of biodegradable tacks in pediatric patients with burns.

Sheridan RL, Petras L, Basha G, Tompkins RG
J Burn Care Rehabil. 1995;16(2 Pt 1):143-4 - PMID: 7775509

Femoral arterial catheterization in paediatric burn patients.

Sheridan RL, Weber JM, Tompkins RG
Burns. 1994;20(5):451-2 - PMID: 7999277

Effectiveness of poloxamer 188 in arresting calcein leakage from thermally damaged isolated skeletal muscle cells.

Padanilam JT, Bischof JC, Lee RC, Cravalho EG, Tompkins RG, Yarmush ML, Toner M
Ann N Y Acad Sci. 1994;720:111-23 - PMID: 7516633

Increased gut permeability early after burns correlates with the extent of burn injury.

Ryan CM, Yarmush ML, Burke JF, Tompkins RG
Crit Care Med. 1992;20(11):1508-12 - PMID: 1424691

Technetium-99m-labeled hydrazino nicotinamide derivatized chemotactic peptide analogs for imaging focal sites of bacterial infection.

Babich JW, Solomon H, Pike MC, Kroon D, Graham W, Abrams MJ, Tompkins RG, Rubin RH, Fischman AJ
J Nucl Med. 1993;34(11):1964-74 - PMID: 8229242

Prompt eschar excision: a treatment system contributing to reduced burn mortality. A statistical evaluation of burn care at the Massachusetts General Hospital (1974-1984).

Tompkins RG, Burke JF, Schoenfeld DA, Bondoc CC, Quinby WC, Behringer GC, Ackroyd FW
Ann Surg. 1986;204(3):272-81 - PMID: 3753058 - PMCID: PMC1251276

Equilibrium binding characteristics of monoclonal antibodies recognizing melanoma cell surface antigens.

Shockley TR, Mandeville JT, Tompkins RG, Yarmush ML
Hybridoma. 1990;9(6):527-44 - PMID: 2076895 - DOI: 10.1089/hyb.1990.9.527

Circulating interleukin-1 and tumor necrosis factor in septic shock and experimental endotoxin fever.

Cannon JG, Tompkins RG, Gelfand JA, Michie HR, Stanford GG, van der Meer JW, Endres S, Lonnemann G, Corsetti J, Chernow B
J Infect Dis. 1990;161(1):79-84 - PMID: 2295861

Long-term in vitro function of adult hepatocytes in a collagen sandwich configuration.

Dunn JC, Tompkins RG, Yarmush ML
Biotechnol Prog. 1991;7(3):237-45 - PMID: 1367596 - DOI: 10.1021/bp00009a007

Ultra-high-efficiency strong cation exchange LC/RPLC/MS/MS for high dynamic range characterization of the human plasma proteome.

Shen Y, Jacobs JM, Camp DG, Fang R, Moore RJ, Smith RD, Xiao W, Davis RW, Tompkins RG
Anal Chem. 2004;76(4):1134-44 - PMID: 14961748 - DOI: 10.1021/ac034869m

Quantitative proteome analysis of human plasma following in vivo lipopolysaccharide administration using 16O/18O labeling and the accurate mass and time tag approach.

Qian WJ, Monroe ME, Liu T, Jacobs JM, Anderson GA, Shen Y, Moore RJ, Anderson DJ, Zhang R, Calvano SE, Lowry SF, Xiao W, Moldawer LL, Davis RW, Tompkins RG, Camp DG, Smith RD,
Mol Cell Proteomics. 2005;4(5):700-9 - PMID: 15753121 - PMCID: PMC1829297 - DOI: 10.1074/mcp.M500045-MCP200

Quantitative analysis of blood vessel permeability of squirrel monkeys.

Tompkins RG
Am J Physiol. 1991;260(4 Pt 2):H1194-204 - PMID: 2012223 - DOI: 10.1152/ajpheart.1991.260.4.H1194

Control of hypertrophic scar growth using antibody-targeted photolysis.

Wolfort SF, Reiken SR, Berthiaume F, Tompkins RG, Yarmush ML
J Surg Res. 1996;62(1):17-22 - PMID: 8606503 - DOI: 10.1006/jsre.1996.0166

Intracompartmental sepsis in burn patients.

Sheridan RL, Tompkins RG, McManus WF, Pruitt BA
J Trauma. 1994;36(3):301-5 - PMID: 8145308

Solid organ procurement from burn patients.

Sheridan RL, Stewart B, Tompkins RG
J Trauma. 1995;38(5):824-5 - PMID: 7760420

Inhaled nitric oxide in burn patients with respiratory failure.

Sheridan RL, Hurford WE, Kacmarek RM, Ritz RH, Yin LM, Ryan CM, Tompkins RG
J Trauma. 1997;42(4):629-34 - PMID: 9137249

Progress in burn treatment and the use of artificial skin.

Tompkins RG, Burke JF
World J Surg. 1991;14(6):819-24 - PMID: 2256353

Site-specific detection of S-nitrosylated PKB alpha/Akt1 from rat soleus muscle using CapLC-Q-TOF(micro) mass spectrometry.

Lu XM, Lu M, Tompkins RG, Fischman AJ
J Mass Spectrom. 2005;40(9):1140-8 - PMID: 16041729 - DOI: 10.1002/jms.885

Occult gastrointestinal bleeding: newer techniques and diagnosis and therapy.

Moncure AC, Tompkins RG, Athanasoulis CA, Welch CE
Adv Surg. 1989;22:141-77 - PMID: 2645744

Antibiotic prophylaxis for group A streptococcal burn wound infection is not necessary.

Sheridan RL, Weber JM, Pasternack MS, Tompkins RG
J Trauma. 2001;51(2):352-5 - PMID: 11493799

Midazolam infusion in pediatric patients with burns who are undergoing mechanical ventilation.

Sheridan RL, McEttrick M, Bacha G, Stoddard F, Tompkins RG
J Burn Care Rehabil. 1995;15(6):515-8 - PMID: 7852455

The metabolic basis of the increase of the increase in energy expenditure in severely burned patients.

Yu YM, Tompkins RG, Ryan CM, Young VR
JPEN J Parenter Enteral Nutr. 1999;23(3):160-8 - PMID: 10338224 - DOI: 10.1177/0148607199023003160

Candidemia in the pediatric patient with burns.

Sheridan RL, Weber JM, Budkevich LG, Tompkins RG
J Burn Care Rehabil. 1996;16(4):440-3 - PMID: 8582925

A 10-year experience with toxic epidermal necrolysis.

Schulz JT, Sheridan RL, Ryan CM, MacKool B, Tompkins RG
J Burn Care Rehabil. 2000;21(3):199-204 - PMID: 10850900

Nosocomial infections in pediatric patients with burns.

Weber JM, Sheridan RL, Pasternack MS, Tompkins RG
Am J Infect Control. 1997;25(3):195-201 - PMID: 9202814

Long-term consequences of toxic epidermal necrolysis in children.

Sheridan RL, Schulz JT, Ryan CM, Schnitzer JJ, Lawlor D, Driscoll DN, Donelan MB, Tompkins RG
Pediatrics. 2002;109(1):74-8 - PMID: 11773544

Emergency management of major hydrofluoric acid exposures.

Sheridan RL, Ryan CM, Quinby WC, Blair J, Tompkins RG, Burke JF
Burns. 1995;21(1):62-4 - PMID: 7718123

Artificial skin.

Schulz JT, Tompkins RG, Burke JF
Annu Rev Med. 2000;51:231-44 - PMID: 10774462 - DOI: 10.1146/annurev.med.51.1.231

Macromolecular transport within heart valves.

Tompkins RG, Schnitzer JJ, Yarmush ML
Circ Res. 1989;64(6):1213-23 - PMID: 2720921

Long-term function of cryopreserved rat hepatocytes in a coculture system.

Sugimachi K, Sosef MN, Baust JM, Fowler A, Tompkins RG, Toner M
Cell Transplant. 2004;13(2):187-95 - PMID: 15129765

Interaction with autologous platelets multiplies interleukin-1 and tumor necrosis factor production in mononuclear cells.

Aiura K, Clark BD, Dinarello CA, Margolis NH, Kaplanski G, Burke JF, Tompkins RG, Gelfand JA
J Infect Dis. 1997;175(1):123-9 - PMID: 8985205

Measurement of 125I-low density lipoprotein uptake in selected tissues of the squirrel monkey by quantitative autoradiography.

Tompkins RG, Schnitzer JJ, Yarmush ML, Colton CK, Smith KA
Am J Pathol. 1988;132(3):526-42 - PMID: 3414782 - PMCID: PMC1880767

Selective activation of peripheral blood T cell subsets by endotoxin infusion in healthy human subjects corresponds to differential chemokine activation.

De AK, Miller-Graziano CL, Calvano SE, Laudanski K, Lowry SF, Moldawer LL, Remick DG, Rajicic N, Schoenfeld D, Tompkins RG
J Immunol. 2005;175(9):6155-62 - PMID: 16237112

Significant reductions in mortality for children with burn injuries through the use of prompt eschar excision.

Tompkins RG, Remensnyder JP, Burke JF, Tompkins DM, Hilton JF, Schoenfeld DA, Behringer GE, Bondoc CC, Briggs SE, Quinby WC
Ann Surg. 1988;208(5):577-85 - PMID: 3190284 - PMCID: PMC1493782

Control of hypertrophic scar growth using selective photothermolysis.

Reiken SR, Wolfort SF, Berthiaume F, Compton C, Tompkins RG, Yarmush ML
Lasers Surg Med. 1997;21(1):7-12 - PMID: 9228634

The acutely burned hand: management and outcome based on a ten-year experience with 1047 acute hand burns.

Sheridan RL, Hurley J, Smith MA, Ryan CM, Bondoc CC, Quinby WC, Tompkins RG, Burke JF
J Trauma. 1995;38(3):406-11 - PMID: 7897728

Rectal necrosis after pelvic crush injury.

Tompkins RG, McCabe CJ, Burke JF, Keating MA, Wright CD
J Trauma. 1988;28(5):697-9 - PMID: 3367418

What's new in burns and metabolism.

Sheridan RL, Tompkins RG
J Am Coll Surg. 2004;198(2):243-63 - PMID: 14759783 - DOI: 10.1016/j.jamcollsurg.2003.11.007

Comparative evaluation of the quantitative utilization of parenterally and enterally administered leucine and L-[1-13C,15N]leucine within the whole body and the splanchnic region.

Yu YM, Young VR, Tompkins RG, Burke JF
JPEN J Parenter Enteral Nutr. 1996;19(3):209-15 - PMID: 8551649 - DOI: 10.1177/0148607195019003209

Both C3a and C3a(desArg) regulate interleukin-6 synthesis in human peripheral blood mononuclear cells.

Takabayashi T, Vannier E, Burke JF, Tompkins RG, Gelfand JA, Clark BD
J Infect Dis. 1998;177(6):1622-8 - PMID: 9607842

Young age is not a predictor of mortality in burns.

Sheridan RL, Weber JM, Schnitzer JJ, Schulz JT, Ryan CM, Tompkins RG
Pediatr Crit Care Med. 2001;2(3):223-224 - PMID: 12793945

Prophylactic antibiotics and their role in the prevention of surgical wound infection.

Sheridan RL, Tompkins RG, Burke JF
Adv Surg. 1994;27:43-65 - PMID: 8140979

Quantitative aspects of interorgan relationships among arginine and citrulline metabolism.

Yu YM, Burke JF, Tompkins RG, Martin R, Young VR
Am J Physiol. 1996;271(6 Pt 1):E1098-109 - PMID: 8997231 - DOI: 10.1152/ajpendo.1996.271.6.E1098

Measurement of muscle protein synthesis by positron emission tomography with L-[methyl-11C]methionine.

Hsu H, Yu YM, Babich JW, Burke JF, Livni E, Tompkins RG, Young VR, Alpert NM, Fischman AJ
Proc Natl Acad Sci U S A. 1996;93(5):1841-6 - PMID: 8700846 - PMCID: PMC39869

Muscle protein synthesis by positron-emission tomography with L-[methyl-11C]methionine in adult humans.

Fischman AJ, Yu YM, Livni E, Babich JW, Young VR, Alpert NM, Tompkins RG
Proc Natl Acad Sci U S A. 1998;95(22):12793-8 - PMID: 9788993 - PMCID: PMC23595

Regional measurement of canine skeletal muscle blood flow by positron emission tomography with H2(15)O.

Fischman AJ, Hsu H, Carter EA, Yu YM, Tompkins RG, Guerrero JL, Young VR, Alpert NM
J Appl Physiol. 2002;92(4):1709-16 - PMID: 11896041 - DOI: 10.1152/japplphysiol.00445.2001

A general model for analysis of the tricarboxylic acid cycle with use of [13C]glutamate isotopomer measurements.

Vogt JA, Fischman AJ, Kempf M, Yu YM, Tompkins RG, Burke JF
Am J Physiol. 1994;266(6 Pt 1):E1012-22 - PMID: 7912892 - DOI: 10.1152/ajpendo.1994.266.6.E1012

Burn therapy 1985: acute management.

Tompkins RG, Burke JF
Intensive Care Med. 1986;12(4):289-95 - PMID: 3531277

Metabolic fate of extrahepatic arginine in liver after burn injury.

Chen CL, Fei Z, Carter EA, Lu XM, Hu RH, Young VR, Tompkins RG, Yu YM
Metabolism. 2003;52(10):1232-9 - PMID: 14564672

Recent clinical experience with cultured autologous epithelium.

Sheridan RL, Tompkins RG
Br J Plast Surg. 1996;49(1):72-4 - PMID: 8705108

Blood glutathione synthesis rates in healthy adults receiving a sulfur amino acid-free diet.

Lyons J, Rauh-Pfeiffer A, Yu YM, Lu XM, Zurakowski D, Tompkins RG, Ajami AM, Young VR, Castillo L
Proc Natl Acad Sci U S A. 2000;97(10):5071-6 - PMID: 10792033 - PMCID: PMC25783 - DOI: 10.1073/pnas.090083297

Enrichment using antibody-coated microfluidic chambers in shear flow: model mixtures of human lymphocytes.

Sin A, Murthy SK, Revzin A, Tompkins RG, Toner M
Biotechnol Bioeng. 2005;91(7):816-26 - PMID: 16037988 - DOI: 10.1002/bit.20556

Effect of flow and surface conditions on human lymphocyte isolation using microfluidic chambers.

Murthy SK, Sin A, Tompkins RG, Toner M
Langmuir. 2004;20(26):11649-55 - PMID: 15595794 - DOI: 10.1021/la048047b

Single-cell chemical lysis in picoliter-scale closed volumes using a microfabricated device.

Irimia D, Tompkins RG, Toner M
Anal Chem. 2004;76(20):6137-43 - PMID: 15481964 - DOI: 10.1021/ac0497508

Continuous flow microfluidic device for rapid erythrocyte lysis.

Sethu P, Anahtar M, Moldawer LL, Tompkins RG, Toner M
Anal Chem. 2004;76(21):6247-53 - PMID: 15516115 - DOI: 10.1021/ac049429p

A device to measure the oxygen uptake rate of attached cells: importance in bioartificial organ design.

Foy BD, Rotem A, Toner M, Tompkins RG, Yarmush ML
Cell Transplant. 1995;3(6):515-27 - PMID: 7881763

Bioengineering of liver assist devices.

Tilles AW, Berthiaume F, Yarmush ML, Tompkins RG, Toner M
J Hepatobiliary Pancreat Surg. 2003;9(6):686-96 - PMID: 12658402 - DOI: 10.1007/s005340200095

Selective adhesion of hepatocytes on patterned surfaces.

Bhatia SN, Toner M, Tompkins RG, Yarmush ML
Ann N Y Acad Sci. 1994;745:187-209 - PMID: 7832508

Efficacy of an extracorporeal flat-plate bioartificial liver in treating fulminant hepatic failure.

Shito M, Tilles AW, Tompkins RG, Yarmush ML, Toner M
J Surg Res. 2003;111(1):53-62 - PMID: 12842448

An extracorporeal microscopy perfusion chamber for on-line studies of environmental effects on cultured hepatocytes.

Borel Rinkes IH, Toner M, Tompkins RG, Yarmush ML
J Biomech Eng. 1994;116(2):135-9 - PMID: 8078319

Development of a microfabricated cytometry platform for characterization and sorting of individual leukocytes.

Revzin A, Sekine K, Sin A, Tompkins RG, Toner M
Lab Chip. 2004;5(1):30-7 - PMID: 15616737 - DOI: 10.1039/b405557h

Immobilized IL-2 preserves the viability of an IL-2 dependent cell line.

Horwitz JI, Toner M, Tompkins RG, Yarmush ML
Mol Immunol. 1993;30(11):1041-8 - PMID: 8350874

Intrahepatic amino acid and glucose metabolism in a D-galactosamine-induced rat liver failure model.

Arai K, Lee K, Berthiaume F, Tompkins RG, Yarmush ML
Hepatology. 2001;34(2):360-71 - PMID: 11481621 - DOI: 10.1053/jhep.2001.26515

Culture matrix configuration and composition in the maintenance of hepatocyte polarity and function.

Moghe PV, Berthiaume F, Ezzell RM, Toner M, Tompkins RG, Yarmush ML
Biomaterials. 1996;17(3):373-85 - PMID: 8745335

Long-term functional recovery of hepatocytes after cryopreservation in a three-dimensional culture configuration.

Borel Rinkes IH, Toner M, Sheeha SJ, Tompkins RG, Yarmush ML
Cell Transplant. 1994;1(4):281-92 - PMID: 1344301

Effects of dimethyl sulfoxide on cultured rat hepatocytes in sandwich configuration.

Borel Rinkes IH, Toner M, Ezzell RM, Tompkins RG, Yarmush ML
Cryobiology. 1992;29(4):443-53 - PMID: 1395682

Ice formation in isolated human hepatocytes and human liver tissue.

Bischof JC, Ryan CM, Tompkins RG, Yarmush ML, Toner M
ASAIO J. 1997;43(4):271-8 - PMID: 9242939

Optimization of rat hepatocyte culture in citrated human plasma.

Washizu J, Berthiaume F, Chan C, Tompkins RG, Toner M, Yarmush ML
J Surg Res. 2000;93(2):237-46 - PMID: 11027466 - DOI: 10.1006/jsre.2000.5986

Effects of hypothermia on the function, membrane integrity, and cytoskeletal structure of hepatocytes.

Stefanovich P, Ezzell RM, Sheehan SJ, Tompkins RG, Yarmush ML, Toner M
Cryobiology. 1995;32(4):389-403 - PMID: 7656572 - DOI: 10.1006/cryo.1995.1039

Amino acid supplementation improves cell-specific functions of the rat hepatocytes exposed to human plasma.

Washizu J, Chan C, Berthiaume F, Tompkins RG, Toner M, Yarmush ML
Tissue Eng. 2000;6(5):497-504 - PMID: 11074936 - DOI: 10.1089/107632700750022143

A new approach to the cryopreservation of hepatocytes in a sandwich culture configuration.

Koebe HG, Dunn JC, Toner M, Sterling LM, Hubel A, Cravalho EG, Yarmush ML, Tompkins RG
Cryobiology. 1990;27(5):576-84 - PMID: 2249459

Nonequilibrium freezing of one-cell mouse embryos. Membrane integrity and developmental potential.

Toner M, Cravalho EG, Stachecki J, Fitzgerald T, Tompkins RG, Yarmush ML, Armant DR
Biophys J. 1993;64(6):1908-21 - PMID: 8369414 - PMCID: PMC1262525 - DOI: 10.1016/S0006-3495(93)81562-5

Assessment of artificial liver support technology.

Yarmush ML, Dunn JC, Tompkins RG
Cell Transplant. 1994;1(5):323-41 - PMID: 1344305

Genetically modified human epidermis overexpressing PDGF-A directs the development of a cellular and vascular connective tissue stroma when transplanted to athymic mice--implications for the use of genetically modified keratinocytes to modulate dermal regeneration.

Eming SA, Lee J, Snow RG, Tompkins RG, Yarmush ML, Morgan JR
J Invest Dermatol. 1995;105(6):756-63 - PMID: 7490468

Antibody-targeted photolysis of bacteria in vivo.

Berthiaume F, Reiken SR, Toner M, Tompkins RG, Yarmush ML
Biotechnology (N Y). 1994;12(7):703-6 - PMID: 7764916

In vitro and in vivo evaluation of albumin synthesis rate of porcine hepatocytes in a flat-plate bioreactor.

Shito M, Kim NH, Baskaran H, Tilles AW, Tompkins RG, Yarmush ML, Toner M
Artif Organs. 2001;25(7):571-8 - PMID: 11493279

Dynamics of cell membrane permeability changes at supraphysiological temperatures.

Bischof JC, Padanilam J, Holmes WH, Ezzell RM, Lee RC, Tompkins RG, Yarmush ML, Toner M
Biophys J. 1995;68(6):2608-14 - PMID: 7647264 - PMCID: PMC1282171 - DOI: 10.1016/S0006-3495(95)80445-5

Regulation of signaling pathways downstream of IGF-I/insulin by androgen in skeletal muscle of glucocorticoid-treated rats.

Yin HN, Chai JK, Yu YM, Shen CA, Wu YQ, Yao YM, Liu H, Liang LM, Tompkins RG, Sheng ZY
J Trauma. 2009;66(4):1083-90 - PMID: 19359918 - PMCID: PMC4085982 - DOI: 10.1097/TA.0b013e31817e7420

Acute adrenal insufficiency in the burn intensive care unit.

Sheridan RL, Ryan CM, Tompkins RG
Burns. 1993;19(1):63-6 - PMID: 8435119

A new approach for sequencing human IRS1 phosphotyrosine-containing peptides using CapLC-Q-TOF(micro).

Lu XM, Lu MY, Fischman AJ, Tompkins RG
J Mass Spectrom. 2005;40(5):599-607 - PMID: 15739155 - DOI: 10.1002/jms.826

Imaging infections with antibodies. A method to localize occult infections.

Tompkins RG, Fischman AJ, Yarmush ML
Chest. 1991;100(3 Suppl):169S-172S - PMID: 1909225

Localization of radiolabeled chemotactic peptide at focal sites of Escherichia coli infection in rabbits: evidence for a receptor-specific mechanism.

Babich JW, Tompkins RG, Graham W, Barrow SA, Fischman AJ
J Nucl Med. 1997;38(8):1316-22 - PMID: 9255175

Imaging infections with antibodies. A quantitative autoradiographic analysis.

Morrel EM, Tompkins RG, Fischman AJ, Wilkinson RA, Yarmush ML
J Immunol Methods. 1990;130(1):39-48 - PMID: 2193059

Antibody-targeted photolysis. Bacteriocidal effects of Sn (IV) chlorin e6-dextran-monoclonal antibody conjugates.

Friedberg JS, Tompkins RG, Rakestraw SL, Warren SW, Fischman AJ, Yarmush ML
Ann N Y Acad Sci. 1991;618:383-93 - PMID: 1706578

Mapping of local renal blood flow with PET and H(2)(15)O.

Alpert NM, Rabito CA, Correia DJ, Babich JW, Littman BH, Tompkins RG, Rubin NT, Rubin RH, Fischman AJ
J Nucl Med. 2002;43(4):470-5 - PMID: 11937589

Autoradiographic method for quantitation of radiolabeled proteins in tissues using indium-111.

Morrell EM, Tompkins RG, Fischman AJ, Wilkinson RA, Burke JF, Rubin RH, Strauss HW, Yarmush ML
J Nucl Med. 1989;30(9):1538-45 - PMID: 2504892

Antisense DNA delivery in vivo: liver targeting by receptor-mediated uptake.

Lu XM, Fischman AJ, Jyawook SL, Hendricks K, Tompkins RG, Yarmush ML
J Nucl Med. 1994;35(2):269-75 - PMID: 8294998

Sn-chlorin e6 antibacterial immunoconjugates. An in vitro and in vivo analysis.

Lu XM, Fischman AJ, Stevens E, Lee TT, Strong L, Tompkins RG, Yarmush ML
J Immunol Methods. 1992;156(1):85-99 - PMID: 1431166

Synthesis of 2-[18F]fluoro-2-deoxy-L-glucose and positron emission tomography studies in monkeys.

Meng J, Elmaleh DR, Jyawook S, Weiss S, Alpert NM, Babich JW, Tompkins RG, Fischman AJ
Nucl Med Biol. 1994;21(4):633-40 - PMID: 9234321

The use of pentafluorophenyl derivatives for the 18F labelling of proteins.

Herman LW, Fischman AJ, Tompkins RG, Hanson RN, Byon C, Strauss HW, Elmaleh DR
Nucl Med Biol. 1994;21(7):1005-10 - PMID: 9234356

Intracellular ice formation during the freezing of hepatocytes cultured in a double collagen gel.

Hubel A, Toner M, Cravalho EG, Yarmush ML, Tompkins RG
Biotechnol Prog. 1992;7(6):554-9 - PMID: 1367755 - DOI: 10.1021/bp00012a011

Cryopreservation of isolated hepatocytes: intracellular ice formation under various chemical and physical conditions.

Harris CL, Toner M, Hubel A, Cravalho EG, Yarmush ML, Tompkins RG
Cryobiology. 1991;28(5):436-44 - PMID: 1752131

Nucleation and growth of ice crystals inside cultured hepatocytes during freezing in the presence of dimethyl sulfoxide.

Karlsson JO, Cravalho EG, Borel Rinkes IH, Tompkins RG, Yarmush ML, Toner M
Biophys J. 1993;65(6):2524-36 - PMID: 8312489 - PMCID: PMC1225995 - DOI: 10.1016/S0006-3495(93)81319-5

A quantitative model of invasive Pseudomonas infection in burn injury.

Stevens EJ, Ryan CM, Friedberg JS, Barnhill RL, Yarmush ML, Tompkins RG
J Burn Care Rehabil. 1994;15(3):232-5 - PMID: 8056812

The Drosophila melanogaster toll pathway participates in resistance to infection by the gram-negative human pathogen Pseudomonas aeruginosa.

Lau GW, Goumnerov BC, Walendziewicz CL, Hewitson J, Xiao W, Mahajan-Miklos S, Tompkins RG, Perkins LA, Rahme LG
Infect Immun. 2003;71(7):4059-66 - PMID: 12819096 - PMCID: PMC162001

Application of genome-wide expression analysis to human health and disease.

Cobb JP, Mindrinos MN, Miller-Graziano C, Calvano SE, Baker HV, Xiao W, Laudanski K, Brownstein BH, Elson CM, Hayden DL, Herndon DN, Lowry SF, Maier RV, Schoenfeld DA, Moldawer LL, Davis RW, Tompkins RG, Baker HV, Bankey P, Billiar T, Brownstein BH, Calvano SE, Camp D, Chaudry I, Cobb JP, Davis RW, Elson CM, Freeman B, Gamelli R, Gibran N, Harbrecht B, Hayden DL, Heagy W, Heimbach D, Herndon DN, Horton J, Hunt J, Laudanski K, Lederer J, Lowry SF, Maier RV, Mannick J, McKinley B, Miller-Grazi ...
Proc Natl Acad Sci U S A. 2005;102(13):4801-6 - PMID: 15781863 - PMCID: PMC555033 - DOI: 10.1073/pnas.0409768102

Whole blood and leukocyte RNA isolation for gene expression analyses.

Feezor RJ, Baker HV, Mindrinos M, Hayden D, Tannahill CL, Brownstein BH, Fay A, MacMillan S, Laramie J, Xiao W, Moldawer LL, Cobb JP, Laudanski K, Miller-Graziano CL, Maier RV, Schoenfeld D, Davis RW, Tompkins RG,
Physiol Genomics. 2004;19(3):247-54 - PMID: 15548831 - DOI: 10.1152/physiolgenomics.00020.2004

A network-based analysis of systemic inflammation in humans.

Calvano SE, Xiao W, Richards DR, Felciano RM, Baker HV, Cho RJ, Chen RO, Brownstein BH, Cobb JP, Tschoeke SK, Miller-Graziano C, Moldawer LL, Mindrinos MN, Davis RW, Tompkins RG, Lowry SF,
Nature. 2005;437(7061):1032-7 - PMID: 16136080 - DOI: 10.1038/nature03985

Dynamics of photoinduced cell plasma membrane injury.

Thorpe WP, Toner M, Ezzell RM, Tompkins RG, Yarmush ML
Biophys J. 1995;68(5):2198-206 - PMID: 7612864 - PMCID: PMC1282125 - DOI: 10.1016/S0006-3495(95)80402-9

Hepatic tissue engineering. Development of critical technologies.

Yarmush ML, Toner M, Dunn JC, Rotem A, Hubel A, Tompkins RG
Ann N Y Acad Sci. 1992;665:238-52 - PMID: 1416606

Cutaneous thermal injury alters macromolecular permeability of rat small intestine.

Carter EA, Tompkins RG, Schiffrin E, Burke JF
Surgery. 1990;107(3):335-41 - PMID: 2309150

Percutaneous cholecystostomy in the critically ill burn patient.

Sheridan RL, Ryan CM, Lee MJ, Mueller PR, Tompkins RG
J Trauma. 1995;38(2):248-51 - PMID: 7869446

Cultured autologous epithelium in patients with burns of ninety percent or more of the body surface.

Sheridan RL, Tompkins RG
J Trauma. 1995;38(1):48-50 - PMID: 7745657

Thermal injury induces very early production of interleukin-1 alpha in the rat by mechanisms other than endotoxemia.

Mester M, Carter EA, Tompkins RG, Gelfand JA, Dinarello CA, Burke JF, Clark BD
Surgery. 1994;115(5):588-96 - PMID: 8178258

Burn depth estimation by use of indocyanine green fluorescence: initial human trial.

Sheridan RL, Schomaker KT, Lucchina LC, Hurley J, Yin LM, Tompkins RG, Jerath M, Torri A, Greaves KW, Bua DP
J Burn Care Rehabil. 1996;16(6):602-4 - PMID: 8582937

Support of the metabolic response to burn injury.

Herndon DN, Tompkins RG
Lancet. 2004;363(9424):1895-902 - PMID: 15183630 - DOI: 10.1016/S0140-6736(04)16360-5

Plasma arginine and leucine kinetics and urea production rates in burn patients.

Yu YM, Young VR, Castillo L, Chapman TE, Tompkins RG, Ryan CM, Burke JF
Metabolism. 1995;44(5):659-66 - PMID: 7752916

Accelerated healing and reduced need for grafting in pediatric patients with burns treated with arginine-glycine-aspartic acid peptide matrix. RGD Study Group.

Hansbrough JF, Herndon DN, Heimbach DM, Solem LD, Gamelli RL, Tompkins RG
J Burn Care Rehabil. 1996;16(4):377-87 - PMID: 8582916

Intestinal production of interleukin-1 alpha during endotoxemia in the mouse.

Mester M, Tompkins RG, Gelfand JA, Dinarello CA, Burke JF, Clark BD
J Surg Res. 1993;54(6):584-91 - PMID: 8412068 - DOI: 10.1006/jsre.1993.1089

Hepatocyte function and extracellular matrix geometry: long-term culture in a sandwich configuration.

Dunn JC, Yarmush ML, Koebe HG, Tompkins RG
FASEB J. 1989;3(2):174-7 - PMID: 2914628

Current expectations for survival in pediatric burns.

Sheridan RL, Remensnyder JP, Schnitzer JJ, Schulz JT, Ryan CM, Tompkins RG
Arch Pediatr Adolesc Med. 2000;154(3):245-9 - PMID: 10710021

A 15-year experience with varicella infections in a pediatric burn unit.

Sheridan RL, Weber JM, Pasternak MM, Mulligan JM, Tompkins RG
Burns. 1999;25(4):353-6 - PMID: 10431985

Energy and protein provisions for thermally injured children revisited: an outcome-based approach for determining requirements.

Prelack K, Cunningham JJ, Sheridan RL, Tompkins RG
J Burn Care Rehabil. 1997;18(2):177-81; discussion 176 - PMID: 9095430

Management of severe toxic epidermal necrolysis in children.

Sheridan RL, Weber JM, Schulz JT, Ryan CM, Low HM, Tompkins RG
J Burn Care Rehabil. 2000;20(6):497-500 - PMID: 10613688

Death in the burn unit: sterile multiple organ failure.

Sheridan RL, Ryan CM, Yin LM, Hurley J, Tompkins RG
Burns. 1998;24(4):307-11 - PMID: 9688194

Inducible nitric oxide synthase plays a role in LPS-induced hyperglycemia and insulin resistance.

Sugita H, Kaneki M, Tokunaga E, Sugita M, Koike C, Yasuhara S, Tompkins RG, Martyn JA
Am J Physiol Endocrinol Metab. 2002;282(2):E386-94 - PMID: 11788371 - DOI: 10.1152/ajpendo.00087.2001

Proline-mediated enhancement of hepatocyte function in a collagen gel sandwich culture configuration.

Lee J, Morgan JR, Tompkins RG, Yarmush ML
FASEB J. 1993;7(6):586-91 - PMID: 8472895

Low-dose inhaled nitric oxide in acutely burned children with profound respiratory failure.

Sheridan RL, Zapol WM, Ritz RH, Tompkins RG
Surgery. 1999;126(5):856-62 - PMID: 10568185

Thermal injury in rats alters glucose utilization by skin, wound, and small intestine, but not by skeletal muscle.

Carter EA, Tompkins RG, Babich JW, Correia J, Bailey EM, Fischman AJ
Metabolism. 1996;45(9):1161-7 - PMID: 8781305

Decreased cerebral glucose utilization in rats during the ebb phase of thermal injury.

Carter EA, Tompkins RG, Babich JW, Correia JA, Fischman AJ
J Trauma. 1996;40(6):930-5 - PMID: 8656479

Increase of sialyltransferase activity in the small intestine following thermal injury in rats.

Ch SW, Carter EA, Tompkins RG, Burke JF
Biochem Biophys Res Commun. 1988;153(1):377-81 - PMID: 3259879

Thermal injury-induced changes in the rat intestine brush border cytoskeleton.

Ezzell RM, Carter EA, Yarmush ML, Tompkins RG
Surgery. 1993;114(3):591-7 - PMID: 8367816

Insulin resistance in thermally-injured rats is associated with post-receptor alterations in skeletal muscle, liver and adipose tissue.

Carter EA, Burks D, Fischman AJ, White M, Tompkins RG
Int J Mol Med. 2004;14(4):653-8 - PMID: 15375597

Hepatic and intestinal blood flow following thermal injury.

Carter EA, Tompkins RG, Burke JF
J Burn Care Rehabil. 1989;9(4):347-50 - PMID: 3220848

Increased transcellular permeability of rat small intestine after thermal injury.

Carter EA, Gonnella A, Tompkins RG
Burns. 1992;18(2):117-20 - PMID: 1590925

Metabolic alterations in muscle of thermally injured rabbits, measured by positron emission tomography.

Carter EA, Tompkins RG, Hsu H, Christian B, Alpert NM, Weise S, Fischman AJ
Life Sci. 1997;61(1):39-44 - PMID: 9200667

Molecular mechanism(s) of burn-induced insulin resistance in murine skeletal muscle: role of IRS phosphorylation.

Zhang Q, Carter EA, Ma BY, White M, Fischman AJ, Tompkins RG
Life Sci. 2005;77(24):3068-77 - PMID: 15982669 - DOI: 10.1016/j.lfs.2005.02.034

Injury-induced inhibition of small intestinal protein and nucleic acid synthesis.

Carter EA, Hatz RA, Yarmush ML, Tompkins RG
Gastroenterology. 1990;98(6):1445-51 - PMID: 1692545

Injury-induced inhibition of fat absorption.

Carter EA, Tompkins RG
J Burn Care Rehabil. 1994;15(2):154-7 - PMID: 8195256

Measurement of muscle protein synthesis by positron emission tomography with L-[methyl-11C]methionine: effects of transamination and transmethylation.

Carter EA, Yu YM, Alpert NM, Bonab AA, Tompkins RG, Fischman AJ
J Trauma. 1999;47(2):341-5 - PMID: 10452471

Additive effects of thermal injury and infection on gut permeability.

Ryan CM, Bailey SH, Carter EA, Schoenfeld DA, Tompkins RG
Arch Surg. 1994;129(3):325-8 - PMID: 8129610

Arterial blood pressure immediately after thermal injury: the role of anesthesia.

Trop M, Carter EA, Schiffrin EJ, Tompkins RG
J Burn Care Rehabil. 1994;15(3):224-31 - PMID: 8056811

Core body temperature responses immediately after cutaneous thermal injury in rats.

Trop M, Tompkins RG, Schiffrin EJ, Carter EA, Burke JF
J Burn Care Rehabil. 1993;13(6):632-8 - PMID: 1469027

Nitric oxide production is intensely and persistently increased in tissue by thermal injury.

Carter EA, Derojas-Walker T, Tamir S, Tannenbaum SR, Yu YM, Tompkins RG
Biochem J. 1994;304 ( Pt 1):201-4 - PMID: 7528006 - PMCID: PMC1137472

Absence of change in hepatic lactate metabolism after burn injury.

Carter EA, Khalid MA, Burke JF, Tompkins RG
Burns. 1993;19(6):475-8 - PMID: 8292229

Redistribution of blood flow after thermal injury and hemorrhagic shock.

Carter EA, Tompkins RG, Yarmush ML, Walker WA, Burke JF
J Appl Physiol. 1988;65(4):1782-8 - PMID: 3182540 - DOI: 10.1152/jappl.1988.65.4.1782

Inhibition of in vivo DNA synthesis in regenerating rat liver following thermal injury.

Carter EA, Kirkham SE, Tompkins RG, Burke JF
Biochem Biophys Res Commun. 1989;160(1):196-201 - PMID: 2785385

Detection of acute bacterial infection within soft tissue injuries using a 99mTc-labeled chemotactic peptide.

Fischman AJ, Babich JW, Barrow SA, Graham W, Carter E, Tompkins RG, Rubin RH
J Trauma. 1995;38(2):223-7 - PMID: 7869440

Technetium-99m-labeled chemotactic peptides: comparison with indium-111-labeled white blood cells for localizing acute bacterial infection in the rabbit.

Babich JW, Graham W, Barrow SA, Dragotakes SC, Tompkins RG, Rubin RH, Fischman AJ
J Nucl Med. 1993;34(12):2176-81 - PMID: 8254406

In vivo bioactivity and biodistribution of chemotactic peptide analogs in nonhuman primates.

Fischman AJ, Rauh D, Solomon H, Babich JW, Tompkins RG, Kroon D, Strauss HW, Rubin RH
J Nucl Med. 1993;34(12):2130-4 - PMID: 8254400

Central role of interleukin-6 in burn induced stimulation of hepatic amino acid transport.

Pawlik TM, Carter EA, Bode BP, Fischman AJ, Tompkins RG
Int J Mol Med. 2003;12(4):541-8 - PMID: 12964032

Isolation and long-term culture of human hepatocytes.

Ryan CM, Carter EA, Jenkins RL, Sterling LM, Yarmush ML, Malt RA, Tompkins RG
Surgery. 1993;113(1):48-54 - PMID: 8417488

Analysis of thermal injury-induced insulin resistance in rodents. Implication of postreceptor mechanisms.

Ikezu T, Okamoto T, Yonezawa K, Tompkins RG, Martyn JA
J Biol Chem. 1997;272(40):25289-95 - PMID: 9312146

Cutaneous burn injury alters relative tricarboxylic acid cycle fluxes in rat liver.

Yarmush DM, MacDonald AD, Foy BD, Berthiaume F, Tompkins RG, Yarmush ML
J Burn Care Rehabil. 1999;20(4):292-302 - PMID: 10425591

TCA cycle flux estimates from NMR- and GC-MS-determined [13C]glutamate isotopomers in liver.

Vogt JA, Yarmush DM, Yu YM, Zupke C, Fischman AJ, Tompkins RG, Burke JF
Am J Physiol. 1997;272(6 Pt 1):C2049-62 - PMID: 9227434 - DOI: 10.1152/ajpcell.1997.272.6.C2049

Proton NMR spectroscopy shows lipids accumulate in skeletal muscle in response to burn trauma-induced apoptosis.

Astrakas LG, Goljer I, Yasuhara S, Padfield KE, Zhang Q, Gopalan S, Mindrinos MN, Dai G, Yu YM, Martyn JA, Tompkins RG, Rahme LG, Tzika AA
FASEB J. 2005;19(11):1431-40 - PMID: 16126910 - DOI: 10.1096/fj.04-2005com

Burn injury causes mitochondrial dysfunction in skeletal muscle.

Padfield KE, Astrakas LG, Zhang Q, Gopalan S, Dai G, Mindrinos MN, Tompkins RG, Rahme LG, Tzika AA
Proc Natl Acad Sci U S A. 2005;102(15):5368-73 - PMID: 15809440 - PMCID: PMC556259 - DOI: 10.1073/pnas.0501211102

Transport of fluorescent dextrans across the rat ileum after cutaneous thermal injury.

Berthiaume F, Ezzell RM, Toner M, Yarmush ML, Tompkins RG
Crit Care Med. 1994;22(3):455-64 - PMID: 7510222

Effect of burn injury on glucose and nitrogen metabolism in the liver: preliminary studies in a perfused liver system.

Yamaguchi Y, Yu YM, Zupke C, Yarmush DM, Berthiaume F, Tompkins RG, Yarmush ML
Surgery. 1997;121(3):295-303 - PMID: 9092130

A rabbit model for metabolic studies after burn injury.

Hu RH, Yu YM, Costa D, Young VR, Ryan CM, Burke JF, Tompkins RG
J Surg Res. 1998;75(2):153-60 - PMID: 9655088 - DOI: 10.1006/jsre.1998.5274

A unique mechanism of desensitization to lipolysis mediated by beta(3)-adrenoceptor in rats with thermal injury.

Ikezu T, Yasuhara S, Granneman JG, Kraemer FB, Okamoto T, Tompkins RG, Martyn JA
Am J Physiol. 1999;277(2 Pt 1):E316-24 - PMID: 10444428

Management strategy in purpura fulminans with multiple organ failure in children.

Sheridan RL, Briggs SE, Remensnyder JP, Tompkins RG
Burns. 1996;22(1):53-6 - PMID: 8719318

Cutaneous herpetic infections complicating burns.

Sheridan RL, Schulz JT, Weber JM, Ryan CM, Pasternack MS, Tompkins RG
Burns. 2000;26(7):621-4 - PMID: 10925184

Retrovirus infection: effect of time and target cell number.

Morgan JR, LeDoux JM, Snow RG, Tompkins RG, Yarmush ML
J Virol. 1995;69(11):6994-7000 - PMID: 7474118 - PMCID: PMC189618

Effects of malignancy and interleukin-2 infusion on gut macromolecular permeability.

Ryan CM, Atkins MB, Mier JW, Gelfand JA, Tompkins RG
Crit Care Med. 1995;23(11):1801-6 - PMID: 7587254

Burn wound closure using permanent skin replacement materials.

Tompkins RG, Burke JF
World J Surg. 1993;16(1):47-52 - PMID: 1290266

Increased survival after massive thermal injuries in adults: preliminary report using artificial skin.

Tompkins RG, Hilton JF, Burke JF, Schoenfeld DA, Hegarty MT, Bondoc CC, Quinby WC, Behringer GE, Ackroyd FW
Crit Care Med. 1989;17(8):734-40 - PMID: 2546715

Maximal parenteral glucose oxidation in hypermetabolic young children: a stable isotope study.

Sheridan RL, Yu YM, Prelack K, Young VR, Burke JF, Tompkins RG
JPEN J Parenter Enteral Nutr. 1998;22(4):212-6 - PMID: 9661121 - DOI: 10.1177/0148607198022004212

Skin substitutes in burns.

Sheridan RL, Tompkins RG
Burns. 1999;25(2):97-103 - PMID: 10208382

Plasma L-5-oxoproline kinetics and whole blood glutathione synthesis rates in severely burned adult humans.

Yu YM, Ryan CM, Fei ZW, Lu XM, Castillo L, Schultz JT, Tompkins RG, Young VR
Am J Physiol Endocrinol Metab. 2002;282(2):E247-58 - PMID: 11788355 - DOI: 10.1152/ajpendo.00206.2001

Gut macromolecular permeability in pancreatitis correlates with severity of disease in rats.

Ryan CM, Schmidt J, Lewandrowski K, Compton CC, Rattner DW, Warshaw AL, Tompkins RG
Gastroenterology. 1993;104(3):890-5 - PMID: 8440440

Burns in children younger than two years of age: an experience with 200 consecutive admissions.

Sheridan RL, Ryan CM, Petras LM, Lydon MK, Weber JM, Tompkins RG
Pediatrics. 1997;100(4):721-3 - PMID: 9310533

Circulating interleukin-1 beta and tumor necrosis factor-alpha concentrations after burn injury in humans.

Cannon JG, Friedberg JS, Gelfand JA, Tompkins RG, Burke JF, Dinarello CA
Crit Care Med. 1992;20(10):1414-9 - PMID: 1395662

Effectiveness of bacteria-controlled nursing units in preventing cross-colonization with resistant bacteria in severely burned children.

Weber JM, Sheridan RL, Schulz JT, Tompkins RG, Ryan CM
Infect Control Hosp Epidemiol. 2002;23(9):549-51 - PMID: 12269456 - DOI: 10.1086/502106

Extracorporeal plasma perfusion of cultured hepatocytes: effect of intermittent perfusion on hepatocyte function and morphology.

Stefanovich P, Matthew HW, Toner M, Tompkins RG, Yarmush ML
J Surg Res. 1996;66(1):57-63 - PMID: 8954832 - DOI: 10.1006/jsre.1996.0372

Evaluation of acellular human dermis as a dermal analog in a composite skin graft.

Medalie DA, Tompkins RG, Morgan JR
ASAIO J. 1997;42(5):M455-62 - PMID: 8944923

Management of burn wounds with prompt excision and immediate closure.

Sheridan RL, Tompkins RG, Burke JF
J Intensive Care Med. 1994;9(1):6-17 - PMID: 10146651 - DOI: 10.1177/088506669400900103

Kinetics of plasma arginine and leucine in pediatric burn patients.

Yu YM, Sheridan RL, Burke JF, Chapman TE, Tompkins RG, Young VR
Am J Clin Nutr. 1996;64(1):60-6 - PMID: 8669415 - DOI: 10.1093/ajcn/64.1.60

Postburn pancreatitis.

Ryan CM, Sheridan RL, Schoenfeld DA, Warshaw AL, Tompkins RG
Ann Surg. 1995;222(2):163-70 - PMID: 7543741 - PMCID: PMC1234774

Arginine and ornithine kinetics in severely burned patients: increased rate of arginine disposal.

Yu YM, Ryan CM, Castillo L, Lu XM, Beaumier L, Tompkins RG, Young VR
Am J Physiol Endocrinol Metab. 2001;280(3):E509-17 - PMID: 11171607 - DOI: 10.1152/ajpendo.2001.280.3.E509

A fulminant hepatic failure model in the rat: involvement of interleukin-1beta and tumor necrosis factor-alpha.

Shito M, Balis UJ, Tompkins RG, Yarmush ML, Toner M
Dig Dis Sci. 2001;46(8):1700-8 - PMID: 11508670

Use of Integra artificial skin is associated with decreased length of stay for severely injured adult burn survivors.

Ryan CM, Schoenfeld DA, Malloy M, Schulz JT, Sheridan RL, Tompkins RG
J Burn Care Rehabil. 2002;23(5):311-7 - PMID: 12352131 - DOI: 10.1097/01.BCR.0000028566.85892.54

Antibody Targeted Photolysis.

Yarmush ML, Thorpe WP, Strong L, Rakestraw SL, Toner M, Tompkins RG
Crit Rev Ther Drug Carrier Syst. 1994;10(3):197-252 - PMID: 8258158

Relations among arginine, citrulline, ornithine, and leucine kinetics in adult burn patients.

Yu YM, Ryan CM, Burke JF, Tompkins RG, Young VR
Am J Clin Nutr. 1995;62(5):960-8 - PMID: 7572742 - DOI: 10.1093/ajcn/62.5.960

An effective technique of scrotal harvest.

Sheridan RL, Ryan CM, Tompkins RG
J Burn Care Rehabil. 1993;14(5):557-8 - PMID: 8245111

Strategies for success in academic surgery.

Souba WW, Gamelli RL, Lorber MI, Thompson JS, Kron IL, Tompkins RG, Hoyt DB
Surgery. 1995;117(1):90-5 - PMID: 7809842

Rapid quantitation of recombinant retroviruses.

Morgan JR, Lee J, Tompkins RG, Yarmush ML
Biotechnol Prog. 1994;10(4):441-6 - PMID: 7765097 - DOI: 10.1021/bp00028a014

A quantitative analysis of tumor specific monoclonal antibody uptake by human melanoma xenografts: effects of antibody immunological properties and tumor antigen expression levels.

Shockley TR, Lin K, Sung C, Nagy JA, Tompkins RG, Dedrick RL, Dvorak HF, Yarmush ML
Cancer Res. 1992;52(2):357-66 - PMID: 1728407

Improved management of the perineal wound after proctectomy.

Tompkins RG, Warshaw AL
Ann Surg. 1985;202(6):760-5 - PMID: 4073988 - PMCID: PMC1251011

Hepatocytes in collagen sandwich: evidence for transcriptional and translational regulation.

Dunn JC, Tompkins RG, Yarmush ML
J Cell Biol. 1992;116(4):1043-53 - PMID: 1734019 - PMCID: PMC2289333

Hepatocytes from rat liver perfusions. Physicochemical effects on polyribosome size.

Dunn JC, Friedberg JS, Tompkins RG, Yarmush ML
ASAIO J. 1993;38(4):841-5 - PMID: 1450483

Acute hand burns in children: management and long-term outcome based on a 10-year experience with 698 injured hands.

Sheridan RL, Baryza MJ, Pessina MA, O'Neill KM, Cipullo HM, Donelan MB, Ryan CM, Schulz JT, Schnitzer JJ, Tompkins RG
Ann Surg. 1999;229(4):558-64 - PMID: 10203090 - PMCID: PMC1191743

Initial experience with a composite autologous skin substitute.

Sheridan RL, Morgan JR, Cusick JL, Petras LM, Lydon MM, Tompkins RG
Burns. 2001;27(5):421-4 - PMID: 11451592

Intraoperative reflectance oximetry in burn patients.

Sheridan RL, Prelack KM, Petras LM, Szyfelbein SK, Tompkins RG
J Clin Monit. 1995;11(1):32-4 - PMID: 7745451

Planimetry study of the percent of body surface represented by the hand and palm: sizing irregular burns is more accurately done with the palm.

Sheridan RL, Petras L, Basha G, Salvo P, Cifrino C, Hinson M, McCabe M, Fallon J, Tompkins RG
J Burn Care Rehabil. 1996;16(6):605-6 - PMID: 8582938

Evolution of intrahepatic carbon, nitrogen, and energy metabolism in a D-galactosamine-induced rat liver failure model.

Yokoyama T, Banta S, Berthiaume F, Nagrath D, Tompkins RG, Yarmush ML
Metab Eng. 2005;7(2):88-103 - PMID: 15781418 - DOI: 10.1016/j.ymben.2004.09.003

Objective estimates of the probability of death from burn injuries.

Ryan CM, Schoenfeld DA, Thorpe WP, Sheridan RL, Cassem EH, Tompkins RG
N Engl J Med. 1998;338(6):362-6 - PMID: 9449729 - DOI: 10.1056/NEJM199802053380604

Permissive hypercapnia as a ventilatory strategy in burned children: effect on barotrauma, pneumonia, and mortality.

Sheridan RL, Kacmarek RM, McEttrick MM, Weber JM, Ryan CM, Doody DP, Ryan DP, Schnitzer JJ, Tompkins RG
J Trauma. 1995;39(5):854-9 - PMID: 7474000

Dishwasher effluent burns in infants.

Sheridan RL, Sheridan MG, Tompkins RG
Pediatrics. 1993;91(1):142-4 - PMID: 8416479

Central venous catheter sepsis with weekly catheter change in paediatric burn patients: an analysis of 221 catheters.

Sheridan RL, Weber JM, Peterson HF, Tompkins RG
Burns. 1995;21(2):127-9 - PMID: 7766321

Genetically modified human keratinocytes overexpressing PDGF-A enhance the performance of a composite skin graft.

Eming SA, Medalie DA, Tompkins RG, Yarmush ML, Morgan JR
Hum Gene Ther. 1998;9(4):529-39 - PMID: 9525314 - DOI: 10.1089/hum.1998.9.4-529

Spatial distribution of tumor-specific monoclonal antibodies in human melanoma xenografts.

Shockley TR, Lin K, Nagy JA, Tompkins RG, Yarmush ML, Dvorak HF
Cancer Res. 1992;52(2):367-76 - PMID: 1728408

Penetration of tumor tissue by antibodies and other immunoproteins.

Shockley TR, Lin K, Nagy JA, Tompkins RG, Dvorak HF, Yarmush ML
Ann N Y Acad Sci. 1991;618:367-82 - PMID: 2006796

Antibody-targeted photolysis: in vitro studies with Sn(IV) chlorin e6 covalently bound to monoclonal antibodies using a modified dextran carrier.

Rakestraw SL, Tompkins RG, Yarmush ML
Proc Natl Acad Sci U S A. 1990;87(11):4217-21 - PMID: 1693435 - PMCID: PMC54079

Preparation and characterization of immunoconjugates for antibody-targeted photolysis.

Rakestraw SL, Tompkins RG, Yarmush ML
Bioconjug Chem. 1991;1(3):212-21 - PMID: 1710935

Analysis of Pseudomonas aeruginosa 4-hydroxy-2-alkylquinolines (HAQs) reveals a role for 4-hydroxy-2-heptylquinoline in cell-to-cell communication.

Déziel E, Lépine F, Milot S, He J, Mindrinos MN, Tompkins RG, Rahme LG
Proc Natl Acad Sci U S A. 2004;101(5):1339-44 - PMID: 14739337 - PMCID: PMC337054 - DOI: 10.1073/pnas.0307694100

Antibody-targeted photolysis: in vitro immunological, photophysical, and cytotoxic properties of monoclonal antibody-dextran-Sn(IV) chlorin e6 immunoconjugates.

Rakestraw SL, Ford WE, Tompkins RG, Rodgers MA, Thorpe WP, Yarmush ML
Biotechnol Prog. 1992;8(1):30-9 - PMID: 1371392 - DOI: 10.1021/bp00013a006

Urinary urea nitrogen is imprecise as a predictor of protein balance in burned children.

Prelack K, Dwyer J, Yu YM, Sheridan RL, Tompkins RG
J Am Diet Assoc. 1997;97(5):489-95 - PMID: 9145086 - DOI: 10.1016/S0002-8223(97)00127-2

Evaluation of human skin reconstituted from composite grafts of cultured keratinocytes and human acellular dermis transplanted to athymic mice.

Medalie DA, Eming SA, Tompkins RG, Yarmush ML, Krueger GG, Morgan JR
J Invest Dermatol. 1996;107(1):121-7 - PMID: 8752850

The burn unit as a resource for the management of acute nonburn conditions in children.

Sheridan RL, Briggs SE, Remensnyder JP, Gagnon SW, Doody DP, Ryan DP, Tompkins RG
J Burn Care Rehabil. 1995;16(1):62-4 - PMID: 7721912

Laser ablation of burns: initial clinical trial.

Sheridan RL, Lydon MM, Petras LM, Schomacker KT, Tompkins RG, Glatter RD, Parrish JA
Surgery. 1999;125(1):92-5 - PMID: 9889803

Prognostic significance of prehospital cardiac or pulmonary resuscitation in paediatric burns patients.

Sheridan RL, Tompkins RG
Burns. 1994;20(3):265-6 - PMID: 8054145

Differences in dermal analogs influence subsequent pigmentation, epidermal differentiation, basement membrane, and rete ridge formation of transplanted composite skin grafts.

Medalie DA, Eming SA, Collins ME, Tompkins RG, Yarmush ML, Morgan JR
Transplantation. 1997;64(3):454-65 - PMID: 9275113

Staphylococcal toxic shock syndrome in a paediatric burn unit.

Bacha EA, Sheridan RL, Donohue GA, Tompkins RG
Burns. 1994;20(6):499-502 - PMID: 7880413

Surgical treatment of infundibular stenosis with intact ventricular septum.

KIRKLIN JW, OPENSHAW CR, TOMPKINS RG
Ann Surg. 1953;137(2):228-31 - PMID: 13017523 - PMCID: PMC1802459

Early and late hemodynamic effects of mitral commissurotomy.

LYONS WS, TOMPKINS RG, KIRKLIN JW, WOOD EH
J Lab Clin Med. 1959;53(4):499-516 - PMID: 13654887

Quantitation of beat-to-beat changes in stroke volume from the aortic pulse contour in man.

WARNER HR, SWAN HJ, CONNOLLY DC, TOMPKINS RG, WOOD EH
J Appl Physiol. 1953;5(9):495-507 - PMID: 13034677 - DOI: 10.1152/jappl.1953.5.9.495

Pulmonary artery wedge pressures in mitral valve disease; relationship to left atrial pressures.

CONNOLLY DC, TOMPKINS RG, LEV R, KIRKLIN JW, WOOD EH
Proc Staff Meet Mayo Clin. 1953;28(3):72-8 - PMID: 13014128

Human recombinant interleukin-1 receptor antagonist in the treatment of sepsis syndrome.

Tompkins RG
Crit Care Med. 1994;22(1):3 - PMID: 8124969

Fulminant hepatic failure treated with anti-endotoxin antibody.

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Development of a Colon Cancer GEMM-Derived Orthotopic Transplant Model for Drug Discovery and Validation.

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Pseudomonas aeruginosa Disrupts Caenorhabditis elegans Iron Homeostasis, Causing a Hypoxic Response and Death.

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A Small Volatile Bacterial Molecule Triggers Mitochondrial Dysfunction in Murine Skeletal Muscle.

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SEK1/MKK4 is required for maintenance of a normal peripheral lymphoid compartment but not for lymphocyte development.

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HDL redox activity is increased in HIV-infected men in association with macrophage activation and noncalcified coronary atherosclerotic plaque.

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IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans.

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Long-term posttraumatic stress symptoms vary inversely with early opiate dosing in children recovering from serious burns: Effects durable at 4 years.

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The Microbiome in Inflammatory Bowel Diseases: Current Status and the Future Ahead.

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Whole Animal Automated Platform for Drug Discovery against Multi-Drug Resistant Staphylococcus aureus.

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Human Genome-Wide RNAi Screen Identifies an Essential Role for Inositol Pyrophosphates in Type-I Interferon Response.

Pulloor NK, Nair S, Kostic AD, Bist P, Weaver JD, Riley AM, Tyagi R, Uchil PD, York JD, Snyder SH, García-Sastre A, Potter BV, Lin R, Shears SB, Xavier RJ, Krishnan MN
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Identification of Host-Targeted Small Molecules That Restrict Intracellular Mycobacterium tuberculosis Growth.

Stanley SA, Barczak AK, Silvis MR, Luo SS, Sogi K, Vokes M, Bray MA, Carpenter AE, Moore CB, Siddiqi N, Rubin EJ, Hung DT
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Enterococcus infection biology: Lessons from invertebrate host models.

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Membrane potential-dependent uptake of (18)F-triphenylphosphonium-a new voltage sensor as an imaging agent for detecting burn-induced apoptosis.

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Progress Toward Synthetic Cells.

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High-Throughput Screening for Novel Anti-Infectives Using a C. elegans Pathogenesis Model.

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Genetic Polymorphisms in Metabolizing Enzymes Modifying the Association Between Smoking and Inflammatory Bowel Diseases.

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Survival From Burns in the New Millennium: 70 Years' Experience From a Single Institution.

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MUT-14 and SMUT-1 DEAD Box RNA Helicases Have Overlapping Roles in Germline RNAi and Endogenous siRNA Formation.

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Caenorhabditis elegans pathways that surveil and defend mitochondria.

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Benchmarking outcomes in the critically injured burn patient.

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Novel Mechanism of Tumor Suppression by Polarity Gene Discs Large 1 (DLG1) Revealed in a Murine Model of Pediatric B-ALL.

Sandoval GJ, Graham DB, Gmyrek GB, Akilesh HM, Fujikawa K, Sammut B, Bhattacharya D, Srivatsan S, Kim A, Shaw AS, Yang-Iott K, Bassing CH, Duncavage E, Xavier RJ, Swat W
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Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense.

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Epinecidin-1 has immunomodulatory effects, facilitating its therapeutic use in a mouse model of Pseudomonas aeruginosa sepsis.

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Pseudomonas aeruginosa PA14 Pathogenesis in Caenorhabditis elegans.

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Dectin-1 dependent LC3 recruitment to phagosomes enhances fungicidal activity in macrophages.

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The Evolutionarily Conserved Mediator Subunit MDT-15/MED15 Links Protective Innate Immune Responses and Xenobiotic Detoxification.

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Detecting differential protein expression in large-scale population proteomics.

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SLCO3A1, a Novel Crohn's Disease-Associated Gene, Regulates NF-?B Activity and Associates with Intestinal Perforation.

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Simvastatin Reduces Burn Injury-Induced Splenic Apoptosis via Downregulation of the TNF-?/NF-?B Pathway.

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Inflammatory Bowel Disease as a Model for Translating the Microbiome.

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AGROBEST: an efficient Agrobacterium-mediated transient expression method for versatile gene function analyses in Arabidopsis seedlings.

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On the Horizon: Research Priorities in Burns for the Next Decade.

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Jennelle L, Hunegnaw R, Dubrovsky L, Pushkarsky T, Fitzgerald ML, Sviridov D, Popratiloff A, Brichacek B, Bukrinsky M
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An Image-Based Genetic Assay Identifies Genes in T1D Susceptibility Loci Controlling Cellular Antiviral Immunity in Mouse.

Liao J, Jijon HB, Kim IR, Goel G, Doan A, Sokol H, Bauer H, Herrmann BG, Lassen KG, Xavier RJ
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Next-Gen Sequencing-Based Mapping and Identification of Ethyl Methanesulfonate-Induced Mutations in Arabidopsis thaliana.

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Autophagy Controls BCG-Induced Trained Immunity and the Response to Intravesical BCG Therapy for Bladder Cancer.

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Autophagy and checkpoints for intracellular pathogen defense.

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Cas9-Based Genome Editing in Arabidopsis and Tobacco.

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BCG-induced trained immunity in NK cells: Role for non-specific protection to infection.

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Gene Pathways That Delay Caenorhabditis elegans Reproductive Senescence.

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Recovery Trajectories After Burn Injury in Young Adults: Does Burn Size Matter?

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Fanconi Anemia Gene Editing by the CRISPR/Cas9 System.

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A Zebrafish Model of Myelodysplastic Syndrome Produced Through tet2 Genomic Editing.

Gjini E, Mansour MR, Sander JD, Moritz N, Nguyen AT, Kesarsing M, Gans E, He S, Chen S, Ko M, Kuang YY, Yang S, Zhou Y, Rodig S, Zon LI, Joung JK, Rao A, Look AT
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Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo.

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Genome editing: a tool for research and therapy: towards a functional understanding of variants for molecular diagnostics using genome editing.

Tsai SQ, Iafrate AJ, Joung JK
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Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage.

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Targeted mutagenesis of zebrafish antithrombin III triggers disseminated intravascular coagulation and thrombosis, revealing insight into function.

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Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1.

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Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity.

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An improved predictive recognition model for Cys(2)-His(2) zinc finger proteins.

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Improving CRISPR-Cas nuclease specificity using truncated guide RNAs.

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Toddler: an embryonic signal that promotes cell movement via Apelin receptors.

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Moving beyond translation: glucose-TOR signaling in the transcriptional control of cell cycle.

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How antibiotics kill bacteria: new models needed?

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The hybrid four-CBS-domain KIN?? subunit functions as the canonical ? subunit of the plant energy sensor SnRK1.

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Morbidity and Survival Probability in Burn Patients in Modern Burn Care.

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Pyruvate Kinase M2 Regulates Hif-1? Activity and IL-1? Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages.

Palsson-McDermott EM, Curtis AM, Goel G, Lauterbach MA, Sheedy FJ, Gleeson LE, van den Bosch MW, Quinn SR, Domingo-Fernandez R, Johnson DG, Jiang J, Israelsen WJ, Keane J, Thomas C, Clish C, Vanden Heiden M, Xavier RJ, O'Neill LA
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Complex host genetics influence the microbiome in inflammatory bowel disease.

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Insect-derived Cecropins Display Activity Against Acinetobacter baumannii in a Whole-Animal High-Throughput Caenorhabditis elegans Model.

Jayamani E, Rajamuthiah R, Larkins-Ford J, Fuchs BB, Conery AL, Vilcinskas A, Ausubel FM, Mylonakis E
Antimicrob Agents Chemother. 2015;59(3):1728-37 - PMID: 25583713 - PMCID: PMC4325797 - DOI: 10.1128/AAC.04198-14

Role of Protein Farnesylation in Burn-Induced Metabolic Derangements and Insulin Resistance in Mouse Skeletal Muscle.

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Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease.

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Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa.

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Exome Sequencing in Suspected Monogenic Dyslipidemias.

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A new antibiotic with potent activity targets MscL.

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Replacing Uridine with 2-Thio-Uridine Enhances the Rate and Fidelity of Nonenzymatic RNA Primer Extension.

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Chromatin regulation at the frontier of synthetic biology.

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The Dynamics of the Human Infant Gut Microbiome in Development and in Progression toward Type 1 Diabetes.

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Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature.

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