Publications - Szostak - 2007
Meena , Sam M, Pierce K, Szostak JW, McLaughlin LW 2',3'-Dideoxy-3'-thionucleoside triphosphates: syntheses and polymerase substrate activities. Org Lett. 2007;9(6):1161-3 - PMID: 17319676 - DOI: 10.1021/ol070147w
Hazen RM, Griffin PL, Carothers JM, Szostak JW Functional information and the emergence of biocomplexity. Proc Natl Acad Sci U S A. 2007;104 Suppl 1:8574-81 - PMID: 17494745 - PMCID: PMC1876432 - DOI: 10.1073/pnas.0701744104
Smith MD, Rosenow MA, Wang M, Allen JP, Szostak JW, Chaput JC Structural insights into the evolution of a non-biological protein: importance of surface residues in protein fold optimization. PLoS One. 2007;2(5):e467 - PMID: 17520026 - PMCID: PMC1867856 - DOI: 10.1371/journal.pone.0000467
Mansy SS, Zhang J, Kümmerle R, Nilsson M, Chou JJ, Szostak JW, Chaput JC Structure and evolutionary analysis of a non-biological ATP-binding protein. J Mol Biol. 2007;371(2):501-13 - PMID: 17583732 - DOI: 10.1016/j.jmb.2007.05.062
Seelig B, Szostak JW Selection and evolution of enzymes from a partially randomized non-catalytic scaffold. Nature. 2007;448(7155):828-31 - PMID: 17700701 - PMCID: PMC4476047 - DOI: 10.1038/nature06032
Tsai CH, Chen J, Szostak JW Enzymatic synthesis of DNA on glycerol nucleic acid templates without stable duplex formation between product and template. Proc Natl Acad Sci U S A. 2007;104(37):14598-603 - PMID: 17785419 - PMCID: PMC1976233 - DOI: 10.1073/pnas.0704211104
Hartman MC, Josephson K, Lin CW, Szostak JW An expanded set of amino acid analogs for the ribosomal translation of unnatural peptides. PLoS One. 2007;2(10):e972 - PMID: 17912351 - PMCID: PMC1989143 - DOI: 10.1371/journal.pone.0000972
Cho GS, Szostak JW Directed evolution of ATP binding proteins from a zinc finger domain by using mRNA display. Chem Biol. 2006;13(2):139-47 - PMID: 16492562 - DOI: 10.1016/j.chembiol.2005.10.015
Carothers JM, Davis JH, Chou JJ, Szostak JW Solution structure of an informationally complex high-affinity RNA aptamer to GTP. RNA. 2006;12(4):567-79 - PMID: 16510427 - PMCID: PMC1421093 - DOI: 10.1261/rna.2251306
Hartman MC, Josephson K, Szostak JW Enzymatic aminoacylation of tRNA with unnatural amino acids. Proc Natl Acad Sci U S A. 2006;103(12):4356-61 - PMID: 16537388 - PMCID: PMC1450175 - DOI: 10.1073/pnas.0509219103
Seebeck FP, Szostak JW Ribosomal synthesis of dehydroalanine-containing peptides. J Am Chem Soc. 2006;128(22):7150-1 - PMID: 16734454 - PMCID: PMC2572134 - DOI: 10.1021/ja060966w
Carothers JM, Oestreich SC, Szostak JW Aptamers selected for higher-affinity binding are not more specific for the target ligand. J Am Chem Soc. 2006;128(24):7929-37 - PMID: 16771507 - PMCID: PMC4287982 - DOI: 10.1021/ja060952q
Salehi-Ashtiani K, Lupták A, Litovchick A, Szostak JW A genomewide search for ribozymes reveals an HDV-like sequence in the human CPEB3 gene. Science. 2006;313(5794):1788-92 - PMID: 16990549 - DOI: 10.1126/science.1129308
Blackburn EH, Greider CW, Szostak JW Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging. Nat Med. 2006;12(10):1133-8 - PMID: 17024208 - DOI: 10.1038/nm1006-1133
Horhota AT, Szostak JW, McLaughlin LW Glycerol nucleoside triphosphates: synthesis and polymerase substrate activities. Org Lett. 2006;8(23):5345-7 - PMID: 17078714 - DOI: 10.1021/ol062232u
Shen X, Valencia CA, Szostak JW, Szostak J, Dong B, Liu R Scanning the human proteome for calmodulin-binding proteins. Proc Natl Acad Sci U S A. 2005;102(17):5969-74 - PMID: 15840729 - PMCID: PMC1087907 - DOI: 10.1073/pnas.0407928102
Chen IA, Salehi-Ashtiani K, Szostak JW RNA catalysis in model protocell vesicles. J Am Chem Soc. 2005;127(38):13213-9 - PMID: 16173749 - PMCID: PMC5072289 - DOI: 10.1021/ja051784p
Ichida JK, Zou K, Horhota A, Yu B, McLaughlin LW, Szostak JW An in vitro selection system for TNA. J Am Chem Soc. 2005;127(9):2802-3 - PMID: 15740086 - PMCID: PMC5072288 - DOI: 10.1021/ja045364w
Horhota A, Zou K, Ichida JK, Yu B, McLaughlin LW, Szostak JW, Chaput JC Kinetic analysis of an efficient DNA-dependent TNA polymerase. J Am Chem Soc. 2005;127(20):7427-34 - PMID: 15898792 - PMCID: PMC5042361 - DOI: 10.1021/ja0428255
Plummer KA, Carothers JM, Yoshimura M, Szostak JW, Verdine GL In vitro selection of RNA aptamers against a composite small molecule-protein surface. Nucleic Acids Res. 2005;33(17):5602-10 - PMID: 16199752 - PMCID: PMC1240114 - DOI: 10.1093/nar/gki867
Sacerdote MG, Szostak JW Semipermeable lipid bilayers exhibit diastereoselectivity favoring ribose. Proc Natl Acad Sci U S A. 2005;102(17):6004-8 - PMID: 15831588 - PMCID: PMC556129 - DOI: 10.1073/pnas.0408440102
Ichida JK, Horhota A, Zou K, McLaughlin LW, Szostak JW High fidelity TNA synthesis by Therminator polymerase. Nucleic Acids Res. 2005;33(16):5219-25 - PMID: 16157867 - PMCID: PMC1214552 - DOI: 10.1093/nar/gki840
Fujikawa SM, Chen IA, Szostak JW Shrink-wrap vesicles. Langmuir. 2005;21(26):12124-9 - PMID: 16342983 - PMCID: PMC2548281 - DOI: 10.1021/la052590q
Zou K, Horhota A, Yu B, Szostak JW, McLaughlin LW Synthesis of alpha-L-threofuranosyl nucleoside triphosphates (tNTPs). Org Lett. 2005;7(8):1485-7 - PMID: 15816733 - PMCID: PMC5022784 - DOI: 10.1021/ol050081+
Josephson K, Hartman MC, Szostak JW Ribosomal synthesis of unnatural peptides. J Am Chem Soc. 2005;127(33):11727-35 - PMID: 16104750 - DOI: 10.1021/ja0515809
Chaput JC, Szostak JW Evolutionary optimization of a nonbiological ATP binding protein for improved folding stability. Chem Biol. 2004;11(6):865-74 - PMID: 15217619 - DOI: 10.1016/j.chembiol.2004.04.006
Hanczyc MM, Szostak JW Replicating vesicles as models of primitive cell growth and division. Curr Opin Chem Biol. 2004;8(6):660-4 - PMID: 15556412 - DOI: 10.1016/j.cbpa.2004.10.002
Chen IA, Szostak JW Membrane growth can generate a transmembrane pH gradient in fatty acid vesicles. Proc Natl Acad Sci U S A. 2004;101(21):7965-70 - PMID: 15148394 - PMCID: PMC419540 - DOI: 10.1073/pnas.0308045101
Chen IA, Roberts RW, Szostak JW The emergence of competition between model protocells. Science. 2004;305(5689):1474-6 - PMID: 15353806 - PMCID: PMC4484590 - DOI: 10.1126/science.1100757
Chen IA, Szostak JW A kinetic study of the growth of fatty acid vesicles. Biophys J. 2004;87(2):988-98 - PMID: 15298905 - PMCID: PMC1304506 - DOI: 10.1529/biophysj.104.039875
Carothers JM, Oestreich SC, Davis JH, Szostak JW Informational complexity and functional activity of RNA structures. J Am Chem Soc. 2004;126(16):5130-7 - PMID: 15099096 - PMCID: PMC5042360 - DOI: 10.1021/ja031504a
Sazani PL, Larralde R, Szostak JW A small aptamer with strong and specific recognition of the triphosphate of ATP. J Am Chem Soc. 2004;126(27):8370-1 - PMID: 15237981 - PMCID: PMC4983724 - DOI: 10.1021/ja049171k
Szostak JW Functional information: Molecular messages. Nature. 2003;423(6941):689 - PMID: 12802312 - DOI: 10.1038/423689a
Huang Z, Szostak JW Evolution of aptamers with a new specificity and new secondary structures from an ATP aptamer. RNA. 2003;9(12):1456-63 - PMID: 14624002 - PMCID: PMC1370500 - DOI: 10.1261/rna.5990203
Chaput JC, Ichida JK, Szostak JW DNA polymerase-mediated DNA synthesis on a TNA template. J Am Chem Soc. 2003;125(4):856-7 - PMID: 12537469 - DOI: 10.1021/ja028589k
Vaish NK, Larralde R, Fraley AW, Szostak JW, McLaughlin LW A novel, modification-dependent ATP-binding aptamer selected from an RNA library incorporating a cationic functionality. Biochemistry. 2003;42(29):8842-51 - PMID: 12873145 - DOI: 10.1021/bi027354i
Huang Z, Szostak JW Selective labeling and detection of specific RNAs in an RNA mixture. Anal Biochem. 2003;315(1):129-33 - PMID: 12672421 - DOI: 10.1016/s0003-2697(02)00701-7
Hanczyc MM, Fujikawa SM, Szostak JW Experimental models of primitive cellular compartments: encapsulation, growth, and division. Science. 2003;302(5645):618-22 - PMID: 14576428 - PMCID: PMC4484575 - DOI: 10.1126/science.1089904
Chaput JC, Szostak JW TNA synthesis by DNA polymerases. J Am Chem Soc. 2003;125(31):9274-5 - PMID: 12889939 - DOI: 10.1021/ja035917n
Szostak JW Molecular biology: RNA gets a grip on translation. Nature. 2002;419(6910):890-1 - PMID: 12410294 - DOI: 10.1038/419890a
Baggio R, Burgstaller P, Hale SP, Putney AR, Lane M, Lipovsek D, Wright MC, Roberts RW, Liu R, Szostak JW, Wagner RW Identification of epitope-like consensus motifs using mRNA display. J Mol Recognit. 2002;15(3):126-34 - PMID: 12203838 - DOI: 10.1002/jmr.567
Davis JH, Szostak JW Isolation of high-affinity GTP aptamers from partially structured RNA libraries. Proc Natl Acad Sci U S A. 2002;99(18):11616-21 - PMID: 12185247 - PMCID: PMC129318 - DOI: 10.1073/pnas.182095699
Keefe AD, Wilson DS, Seelig B, Szostak JW One-step purification of recombinant proteins using a nanomolar-affinity streptavidin-binding peptide, the SBP-Tag. Protein Expr Purif. 2001;23(3):440-6 - PMID: 11722181 - DOI: 10.1006/prep.2001.1515
Keefe AD, Szostak JW Functional proteins from a random-sequence library. Nature. 2001;410(6829):715-8 - PMID: 11287961 - PMCID: PMC4476321 - DOI: 10.1038/35070613
Salehi-Ashtiani K, Szostak JW In vitro evolution suggests multiple origins for the hammerhead ribozyme. Nature. 2001;414(6859):82-4 - PMID: 11689947 - DOI: 10.1038/35102081
Szostak JW, Bartel DP, Luisi PL Synthesizing life. Nature. 2001;409(6818):387-90 - PMID: 11201752 - DOI: 10.1038/35053176
Wilson DS, Keefe AD, Szostak JW The use of mRNA display to select high-affinity protein-binding peptides. Proc Natl Acad Sci U S A. 2001;98(7):3750-5 - PMID: 11274392 - PMCID: PMC31124 - DOI: 10.1073/pnas.061028198
Szostak JW In vitro selection and directed evolution. Harvey Lect. 2000;93:95-118 - PMID: 10941421
Wilson DS, Szostak JW In vitro selection of functional nucleic acids. Annu Rev Biochem. 2000;68:611-47 - PMID: 10872462 - DOI: 10.1146/annurev.biochem.68.1.611
Cho G, Keefe AD, Liu R, Wilson DS, Szostak JW Constructing high complexity synthetic libraries of long ORFs using in vitro selection. J Mol Biol. 2000;297(2):309-19 - PMID: 10715203 - DOI: 10.1006/jmbi.2000.3571
Vaish NK, Fraley AW, Szostak JW, McLaughlin LW Expanding the structural and functional diversity of RNA: analog uridine triphosphates as candidates for in vitro selection of nucleic acids. Nucleic Acids Res. 2000;28(17):3316-22 - PMID: 10954600 - PMCID: PMC110695 - DOI: 10.1093/nar/28.17.3316
Lee N, Bessho Y, Wei K, Szostak JW, Suga H Ribozyme-catalyzed tRNA aminoacylation. Nat Struct Biol. 2000;7(1):28-33 - PMID: 10625423 - DOI: 10.1038/71225
Liu R, Barrick JE, Szostak JW, Roberts RW Optimized synthesis of RNA-protein fusions for in vitro protein selection. Methods Enzymol. 2000;318:268-93 - PMID: 10889994 - DOI: 10.1016/s0076-6879(00)18058-9
Holeman LA, Robinson SL, Szostak JW, Wilson C Isolation and characterization of fluorophore-binding RNA aptamers. Fold Des. 1999;3(6):423-31 - PMID: 9889155 - DOI: 10.1016/S1359-0278(98)00059-5
Suga H, Lohse PA, Szostak JW Structural and kinetic characterization of an acyl transferase ribozyme. J Am Chem Soc. 1998;120(6):1151-6 - PMID: 11541113 - DOI: 10.1021/ja972472s
Suga H, Cowan JA, Szostak JW Unusual metal ion catalysis in an acyl-transferase ribozyme. Biochemistry. 1998;37(28):10118-25 - PMID: 9665717 - DOI: 10.1021/bi980432a
Wilson C, Szostak JW Isolation of a fluorophore-specific DNA aptamer with weak redox activity. Chem Biol. 1998;5(11):609-17 - PMID: 9831529 - DOI: 10.1016/s1074-5521(98)90289-7
Hager AJ, Szostak JW Isolation of novel ribozymes that ligate AMP-activated RNA substrates. Chem Biol. 1997;4(8):607-17 - PMID: 9281527 - DOI: 10.1016/s1074-5521(97)90246-5
Szostak JW Introduction: Combinatorial Chemistry. Chem Rev. 1997;97(2):347-348 - PMID: 11848873 - DOI: 10.1021/cr9700080
Roberts RW, Szostak JW RNA-peptide fusions for the in vitro selection of peptides and proteins. Proc Natl Acad Sci U S A. 1997;94(23):12297-302 - PMID: 9356443 - PMCID: PMC24913 - DOI: 10.1073/pnas.94.23.12297
Dieckmann T, Butcher SE, Sassanfar M, Szostak JW, Feigon J Mutant ATP-binding RNA aptamers reveal the structural basis for ligand binding. J Mol Biol. 1997;273(2):467-78 - PMID: 9344753 - DOI: 10.1006/jmbi.1997.1329
Chapman KB, Szostak JW In vitro selection of catalytic RNAs. Curr Opin Struct Biol. 1997;4:618-22 - PMID: 11539575 - DOI: 10.1016/s0959-440x(94)90227-5
Hager AJ, Pollard JD, Szostak JW Ribozymes: aiming at RNA replication and protein synthesis. Chem Biol. 1996;3(9):717-25 - PMID: 8939686 - DOI: 10.1016/s1074-5521(96)90246-x
Rohatgi R, Bartel DP, Szostak JW Kinetic and mechanistic analysis of nonenzymatic, template-directed oligoribonucleotide ligation. J Am Chem Soc. 1996;118(14):3332-9 - PMID: 11539267 - DOI: 10.1021/ja953712b
Lohse PA, Szostak JW Ribozyme-catalysed amino-acid transfer reactions. Nature. 1996;381(6581):442-4 - PMID: 8632803 - DOI: 10.1038/381442a0
Lorsch JR, Szostak JW Chance and necessity in the selection of nucleic acid catalysts. Acc Chem Res. 1996;29(2):103-10 - PMID: 11539421 - DOI: 10.1021/ar9501378
Huang Z, Szostak JW A simple method for 3'-labeling of RNA. Nucleic Acids Res. 1996;24(21):4360-1 - PMID: 8932396 - PMCID: PMC146232 - DOI: 10.1093/nar/24.21.4360
Rohatgi R, Bartel DP, Szostak JW Nonenzymatic, template-directed ligation of oligoribonucleotides is highly regioselective for the formation of 3'-5' phosphodiester bonds. J Am Chem Soc. 1996;118(14):3340-4 - PMID: 11539268 - DOI: 10.1021/ja9537134
Cuenoud B, Szostak JW A DNA metalloenzyme with DNA ligase activity. Nature. 1995;375(6532):611-4 - PMID: 7791880 - DOI: 10.1038/375611a0
Chapman KB, Szostak JW Isolation of a ribozyme with 5'-5' ligase activity. Chem Biol. 1995;2(5):325-33 - PMID: 9383434 - DOI: 10.1016/1074-5521(95)90051-9
Ekland EH, Szostak JW, Bartel DP Structurally complex and highly active RNA ligases derived from random RNA sequences. Science. 1995;269(5222):364-70 - PMID: 7618102 - DOI: 10.1126/science.7618102
Whoriskey SK, Usman N, Szostak JW Total chemical synthesis of a ribozyme derived from a group I intron. Proc Natl Acad Sci U S A. 1995;92(7):2465-9 - PMID: 7708666 - PMCID: PMC42238 - DOI: 10.1073/pnas.92.7.2465
Lorsch JR, Bartel DP, Szostak JW Reverse transcriptase reads through a 2'-5'linkage and a 2'-thiophosphate in a template. Nucleic Acids Res. 1995;23(15):2811-4 - PMID: 7544885 - PMCID: PMC307115 - DOI: 10.1093/nar/23.15.2811
Lorsch JR, Szostak JW Kinetic and thermodynamic characterization of the reaction catalyzed by a polynucleotide kinase ribozyme. Biochemistry. 1995;34(46):15315-27 - PMID: 7578148 - DOI: 10.1021/bi00046a041
Huizenga DE, Szostak JW A DNA aptamer that binds adenosine and ATP. Biochemistry. 1995;34(2):656-65 - PMID: 7819261 - DOI: 10.1021/bi00002a033
Wilson C, Szostak JW In vitro evolution of a self-alkylating ribozyme. Nature. 1995;374(6525):777-82 - PMID: 7723823 - DOI: 10.1038/374777a0
Lauhon CT, Szostak JW RNA aptamers that bind flavin and nicotinamide redox cofactors. J Am Chem Soc. 1995;117(4):1246-57 - PMID: 11539282 - DOI: 10.1021/ja00109a008
Lorsch JR, Szostak JW In vitro evolution of new ribozymes with polynucleotide kinase activity. Nature. 1994;371(6492):31-6 - PMID: 7521014 - DOI: 10.1038/371031a0
Hanna M, Szostak JW Suppression of mutations in the core of the Tetrahymena ribozyme by spermidine, ethanol and by substrate stabilization. Nucleic Acids Res. 1994;22(24):5326-31 - PMID: 7816622 - PMCID: PMC332078 - DOI: 10.1093/nar/22.24.5326
Lin CW, Hanna M, Szostak JW Evidence that the guanosine substrate of the Tetrahymena ribozyme is bound in the anti conformation and that N7 contributes to binding. Biochemistry. 1994;33(9):2703-7 - PMID: 8117735 - DOI: 10.1021/bi00175a045
Peterson RD, Bartel DP, Szostak JW, Horvath SJ, Feigon J 1H NMR studies of the high-affinity Rev binding site of the Rev responsive element of HIV-1 mRNA: base pairing in the core binding element. Biochemistry. 1994;33(18):5357-66 - PMID: 8180157 - DOI: 10.1021/bi00184a001
Green R, Szostak JW In vitro genetic analysis of the hinge region between helical elements P5-P4-P6 and P7-P3-P8 in the sunY group I self-splicing intron. J Mol Biol. 1994;235(1):140-55 - PMID: 7507168 - DOI: 10.1016/s0022-2836(05)80022-1
Lorsch JR, Szostak JW In vitro selection of RNA aptamers specific for cyanocobalamin. Biochemistry. 1994;33(4):973-82 - PMID: 7508262 - DOI: 10.1021/bi00170a016
Sassanfar M, Szostak JW An RNA motif that binds ATP. Nature. 1993;364(6437):550-3 - PMID: 7687750 - DOI: 10.1038/364550a0
Doudna JA, Usman N, Szostak JW Ribozyme-catalyzed primer extension by trinucleotides: a model for the RNA-catalyzed replication of RNA. Biochemistry. 1993;32(8):2111-5 - PMID: 7680575 - DOI: 10.1021/bi00059a032
Bartel DP, Szostak JW Isolation of new ribozymes from a large pool of random sequences [see comment]. Science. 1993;261(5127):1411-8 - PMID: 7690155 - DOI: 10.1126/science.7690155
Szostak JW Ribozymes. Evolution ex vivo. Nature. 1993;361(6408):119-20 - PMID: 7678448 - DOI: 10.1038/361119a0
Ross LO, Treco D, Nicolas A, Szostak JW, Dawson D Meiotic recombination on artificial chromosomes in yeast. Genetics. 1992;131(3):541-50 - PMID: 1385793 - PMCID: PMC1205028 - DOI: 10.1093/genetics/131.3.541
Park EC, Finley D, Szostak JW A strategy for the generation of conditional mutations by protein destabilization. Proc Natl Acad Sci U S A. 1992;89(4):1249-52 - PMID: 1311090 - PMCID: PMC48426 - DOI: 10.1073/pnas.89.4.1249
Szostak JW In vitro genetics. Trends Biochem Sci. 1992;17(3):89-93 - PMID: 1384177 - DOI: 10.1016/0968-0004(92)90242-2
Green R, Szostak JW Selection of a ribozyme that functions as a superior template in a self-copying reaction. Science. 1992;258(5090):1910-5 - PMID: 1470913 - DOI: 10.1126/science.1470913
Ellington AD, Szostak JW Selection in vitro of single-stranded DNA molecules that fold into specific ligand-binding structures. Nature. 1992;355(6363):850-2 - PMID: 1538766 - DOI: 10.1038/355850a0
Park EC, Szostak JW ARD1 and NAT1 proteins form a complex that has N-terminal acetyltransferase activity. EMBO J. 1992;11(6):2087-93 - PMID: 1600941 - PMCID: PMC556675 - DOI: 10.1002/j.1460-2075.1992.tb05267.x
Bartel DP, Doudna JA, Usman N, Szostak JW Template-directed primer extension catalyzed by the Tetrahymena ribozyme. Mol Cell Biol. 1991;11(6):3390-4 - PMID: 2038341 - PMCID: PMC360195 - DOI: 10.1128/mcb.11.6.3390
Doudna JA, Couture S, Szostak JW A multisubunit ribozyme that is a catalyst of and template for complementary strand RNA synthesis. Science. 1991;251(5001):1605-8 - PMID: 1707185 - DOI: 10.1126/science.1707185
Pace U, Szostak JW Mutations in a semiconserved region of the Tetrahymena intron. FEBS Lett. 1991;280(1):171-4 - PMID: 2009960 - DOI: 10.1016/0014-5793(91)80230-z
Green R, Szostak JW, Benner SA, Rich A, Usman N Synthesis of RNA containing inosine: analysis of the sequence requirements for the 5' splice site of the Tetrahymena group I intron. Nucleic Acids Res. 1991;19(15):4161-6 - PMID: 1714564 - PMCID: PMC328556 - DOI: 10.1093/nar/19.15.4161
Sun H, Dawson D, Szostak JW Genetic and physical analyses of sister chromatid exchange in yeast meiosis. Mol Cell Biol. 1991;11(12):6328-36 - PMID: 1944292 - PMCID: PMC361828 - DOI: 10.1128/mcb.11.12.6328
Bartel DP, Zapp ML, Green MR, Szostak JW HIV-1 Rev regulation involves recognition of non-Watson-Crick base pairs in viral RNA. Cell. 1991;67(3):529-36 - PMID: 1934059 - DOI: 10.1016/0092-8674(91)90527-6
Schultes NP, Szostak JW A poly(dA.dT) tract is a component of the recombination initiation site at the ARG4 locus in Saccharomyces cerevisiae. Mol Cell Biol. 1991;11(1):322-8 - PMID: 1986228 - PMCID: PMC359622 - DOI: 10.1128/mcb.11.1.322
Sun H, Treco D, Szostak JW Extensive 3'-overhanging, single-stranded DNA associated with the meiosis-specific double-strand breaks at the ARG4 recombination initiation site. Cell. 1991;64(6):1155-61 - PMID: 2004421 - DOI: 10.1016/0092-8674(91)90270-9
Lichten M, Goyon C, Schultes NP, Treco D, Szostak JW, Haber JE, Nicolas A Detection of heteroduplex DNA molecules among the products of Saccharomyces cerevisiae meiosis. Proc Natl Acad Sci U S A. 1990;87(19):7653-7 - PMID: 2217196 - PMCID: PMC54806 - DOI: 10.1073/pnas.87.19.7653
Michel F, Ellington AD, Couture S, Szostak JW Phylogenetic and genetic evidence for base-triples in the catalytic domain of group I introns. Nature. 1990;347(6293):578-80 - PMID: 2215683 - DOI: 10.1038/347578a0
Schultes NP, Szostak JW Decreasing gradients of gene conversion on both sides of the initiation site for meiotic recombination at the ARG4 locus in yeast. Genetics. 1990;126(4):813-22 - PMID: 1981763 - PMCID: PMC1204280 - DOI: 10.1093/genetics/126.4.813
Couture S, Ellington AD, Gerber AS, Cherry JM, Doudna JA, Green R, Hanna M, Pace U, Rajagopal J, Szostak JW Mutational analysis of conserved nucleotides in a self-splicing group I intron. J Mol Biol. 1990;215(3):345-58 - PMID: 1700131 - DOI: 10.1016/s0022-2836(05)80356-0
Ellington AD, Szostak JW In vitro selection of RNA molecules that bind specific ligands. Nature. 1990;346(6287):818-22 - PMID: 1697402 - DOI: 10.1038/346818a0
Green R, Ellington AD, Szostak JW In vitro genetic analysis of the Tetrahymena self-splicing intron. Nature. 1990;347(6291):406-8 - PMID: 2215650 - DOI: 10.1038/347406a0
Doudna JA, Szostak JW, Rich A, Usman N Chemical synthesis of oligoribonucleotides containing 2-aminopurine: substrates for the investigation of ribozyme function. J Org Chem. 1990;55(21):5547-9 - PMID: 11540922 - DOI: 10.1021/jo00308a003
Schultes NP, Ellington AD, Cherry JM, Szostak JW Saccharomyces cerevisiae homoserine kinase is homologous to prokaryotic homoserine kinases. Gene. 1990;96(2):177-80 - PMID: 2176637 - DOI: 10.1016/0378-1119(90)90250-u
Park EC, Szostak JW Point mutations in the yeast histone H4 gene prevent silencing of the silent mating type locus HML. Mol Cell Biol. 1990;10(9):4932-4 - PMID: 2117703 - PMCID: PMC361112 - DOI: 10.1128/mcb.10.9.4932
Michel F, Hanna M, Green R, Bartel DP, Szostak JW The guanosine binding site of the Tetrahymena ribozyme. Nature. 1989;342(6248):391-5 - PMID: 2685606 - DOI: 10.1038/342391a0
Sun H, Treco D, Schultes NP, Szostak JW Double-strand breaks at an initiation site for meiotic gene conversion. Nature. 1989;338(6210):87-90 - PMID: 2645528 - DOI: 10.1038/338087a0
Nicolas A, Treco D, Schultes NP, Szostak JW An initiation site for meiotic gene conversion in the yeast Saccharomyces cerevisiae. Nature. 1989;338(6210):35-9 - PMID: 2537472 - DOI: 10.1038/338035a0
Szostak JW Telomerase: the beginning of the ends. Nature. 1989;337(6205):303-4 - PMID: 2765013 - DOI: 10.1038/337303a0
Doudna JA, Szostak JW Miniribozymes, small derivatives of the sunY intron, are catalytically active. Mol Cell Biol. 1989;9(12):5480-3 - PMID: 2685567 - PMCID: PMC363717 - DOI: 10.1128/mcb.9.12.5480
Doudna JA, Cormack BP, Szostak JW RNA structure, not sequence, determines the 5' splice-site specificity of a group I intron. Proc Natl Acad Sci U S A. 1989;86(19):7402-6 - PMID: 2678103 - PMCID: PMC298070 - DOI: 10.1073/pnas.86.19.7402
Rajagopal J, Doudna JA, Szostak JW Stereochemical course of catalysis by the Tetrahymena ribozyme. Science. 1989;244(4905):692-4 - PMID: 2470151 - DOI: 10.1126/science.2470151
Lundblad V, Szostak JW A mutant with a defect in telomere elongation leads to senescence in yeast. Cell. 1989;57(4):633-43 - PMID: 2655926 - DOI: 10.1016/0092-8674(89)90132-3
Doudna JA, Szostak JW RNA-catalysed synthesis of complementary-strand RNA. Nature. 1989;339(6225):519-22 - PMID: 2660003 - DOI: 10.1038/339519a0
Doudna JA, Gerber AS, Cherry JM, Szostak JW Genetic dissection of an RNA enzyme. Cold Spring Harb Symp Quant Biol. 1988;52:173-80 - PMID: 2456876 - DOI: 10.1101/sqb.1987.052.01.022
Orr-Weaver TL, Nicolas A, Szostak JW Gene conversion adjacent to regions of double-strand break repair. Mol Cell Biol. 1988;8(12):5292-8 - PMID: 3072478 - PMCID: PMC365631 - DOI: 10.1128/mcb.8.12.5292
Allshire RC, Gosden JR, Cross SH, Cranston G, Rout D, Sugawara N, Szostak JW, Fantes PA, Hastie ND Telomeric repeat from T. thermophila cross hybridizes with human telomeres. Nature. 1988;332(6165):656-9 - PMID: 2833706 - DOI: 10.1038/332656a0
Murray AW, Claus TE, Szostak JW Characterization of two telomeric DNA processing reactions in Saccharomyces cerevisiae. Mol Cell Biol. 1988;8(11):4642-50 - PMID: 3062364 - PMCID: PMC365553 - DOI: 10.1128/mcb.8.11.4642
Whiteway M, Freedman R, Van Arsdell S, Szostak JW, Thorner J The yeast ARD1 gene product is required for repression of cryptic mating-type information at the HML locus. Mol Cell Biol. 1987;7(10):3713-22 - PMID: 3316986 - PMCID: PMC368027 - DOI: 10.1128/mcb.7.10.3713
Matsumoto T, Fukui K, Niwa O, Sugawara N, Szostak JW, Yanagida M Identification of healed terminal DNA fragments in linear minichromosomes of Schizosaccharomyces pombe. Mol Cell Biol. 1987;7(12):4424-30 - PMID: 2830493 - PMCID: PMC368126 - DOI: 10.1128/mcb.7.12.4424
Burke JM, Belfort M, Cech TR, Davies RW, Schweyen RJ, Shub DA, Szostak JW, Tabak HF Structural conventions for group I introns. Nucleic Acids Res. 1987;15(18):7217-21 - PMID: 3658691 - PMCID: PMC306243 - DOI: 10.1093/nar/15.18.7217
Reynolds AE, Murray AW, Szostak JW Roles of the 2 microns gene products in stable maintenance of the 2 microns plasmid of Saccharomyces cerevisiae. Mol Cell Biol. 1987;7(10):3566-73 - PMID: 3316982 - PMCID: PMC368010 - DOI: 10.1128/mcb.7.10.3566
Murray AW, Szostak JW Artificial chromosomes. Sci Am. 1987;257(5):62-8 - PMID: 3317814 - DOI: 10.1038/scientificamerican1187-62
Murray AW, Szostak JW Chromosome segregation in mitosis and meiosis. Annu Rev Cell Biol. 1987;1:289-315 - PMID: 3916318 - DOI: 10.1146/annurev.cb.01.110185.001445
Murray AW, Szostak JW Construction and behavior of circularly permuted and telocentric chromosomes in Saccharomyces cerevisiae. Mol Cell Biol. 1986;6(9):3166-72 - PMID: 3537731 - PMCID: PMC367052 - DOI: 10.1128/mcb.6.9.3166
Dawson DS, Murray AW, Szostak JW An alternative pathway for meiotic chromosome segregation in yeast. Science. 1986;234(4777):713-7 - PMID: 3535068 - DOI: 10.1126/science.3535068
Szostak JW Enzymatic activity of the conserved core of a group I self-splicing intron. Nature. 1986;322(6074):83-6 - PMID: 3014350 - DOI: 10.1038/322083a0
Murray AW, Schultes NP, Szostak JW Chromosome length controls mitotic chromosome segregation in yeast. Cell. 1986;45(4):529-36 - PMID: 3518944 - DOI: 10.1016/0092-8674(86)90284-9
Ruby SW, Szostak JW Specific Saccharomyces cerevisiae genes are expressed in response to DNA-damaging agents. Mol Cell Biol. 1985;5(1):75-84 - PMID: 3920512 - PMCID: PMC366680 - DOI: 10.1128/mcb.5.1.75
Whiteway M, Szostak JW The ARD1 gene of yeast functions in the switch between the mitotic cell cycle and alternative developmental pathways. Cell. 1985;43(2 Pt 1):483-92 - PMID: 3907857 - DOI: 10.1016/0092-8674(85)90178-3
Orr-Weaver TL, Szostak JW Fungal recombination. Microbiol Rev. 1985;49(1):33-58 - PMID: 3884994 - PMCID: PMC373016 - DOI: 10.1128/mr.49.1.33-58.1985
Shampay J, Szostak JW, Blackburn EH DNA sequences of telomeres maintained in yeast. Nature. 1984;310(5973):154-7 - PMID: 6330571 - DOI: 10.1038/310154a0
Dunn B, Szauter P, Pardue ML, Szostak JW Transfer of yeast telomeres to linear plasmids by recombination. Cell. 1984;39(1):191-201 - PMID: 6091911 - DOI: 10.1016/0092-8674(84)90205-8
Walmsley RM, Szostak JW, Petes TD Is there left-handed DNA at the ends of yeast chromosomes?. Nature. 1983;302(5903):84-6 - PMID: 6338397 - DOI: 10.1038/302084a0
Orr-Weaver TL, Szostak JW Multiple, tandem plasmid integration in Saccharomyces cerevisiae. Mol Cell Biol. 1983;3(4):747-9 - PMID: 6343844 - PMCID: PMC368590 - DOI: 10.1128/mcb.3.4.747
Sugawara N, Szostak JW Recombination between sequences in nonhomologous positions. Proc Natl Acad Sci U S A. 1983;80(18):5675-9 - PMID: 6351064 - PMCID: PMC384321 - DOI: 10.1073/pnas.80.18.5675
Szostak JW A rapid procedure for the construction of linear yeast plasmids. Methods Enzymol. 1983;101:245-52 - PMID: 6310327 - DOI: 10.1016/0076-6879(83)01018-6
Szostak JW Replication and resolution of telomeres in yeast. Cold Spring Harb Symp Quant Biol. 1983;47 Pt 2:1187-94 - PMID: 6305577 - DOI: 10.1101/sqb.1983.047.01.134
Orr-Weaver TL, Szostak JW, Rothstein RJ Genetic applications of yeast transformation with linear and gapped plasmids. Methods Enzymol. 1983;101:228-45 - PMID: 6310326 - DOI: 10.1016/0076-6879(83)01017-4
Szostak JW, Orr-Weaver TL, Rothstein RJ, Stahl FW The double-strand-break repair model for recombination. Cell. 1983;33(1):25-35 - PMID: 6380756 - DOI: 10.1016/0092-8674(83)90331-8
Ruby SW, Szostak JW, Murray AW Cloning regulated yeast genes from a pool of lacZ fusions. Methods Enzymol. 1983;101:253-69 - PMID: 6310328 - DOI: 10.1016/0076-6879(83)01019-8
Murray AW, Szostak JW Pedigree analysis of plasmid segregation in yeast. Cell. 1983;34(3):961-70 - PMID: 6354471 - DOI: 10.1016/0092-8674(83)90553-6
Brown PA, Szostak JW Yeast vectors with negative selection. Methods Enzymol. 1983;101:278-90 - PMID: 6310330 - DOI: 10.1016/0076-6879(83)01021-6
Orr-Weaver TL, Szostak JW Yeast recombination: the association between double-strand gap repair and crossing-over. Proc Natl Acad Sci U S A. 1983;80(14):4417-21 - PMID: 6308623 - PMCID: PMC384049 - DOI: 10.1073/pnas.80.14.4417
Murray AW, Szostak JW Construction of artificial chromosomes in yeast. Nature. 1983;305(5931):189-93 - PMID: 6350893 - DOI: 10.1038/305189a0
Sugawara N, Szostak JW Construction of specific chromosomal rearrangements in yeast. Methods Enzymol. 1983;101:269-78 - PMID: 6310329 - DOI: 10.1016/0076-6879(83)01020-4
Szostak JW, Blackburn EH Cloning yeast telomeres on linear plasmid vectors. Cell. 1982;29(1):245-55 - PMID: 6286143 - DOI: 10.1016/0092-8674(82)90109-x
Stiles JI, Szostak JW, Young AT, Wu R, Consaul S, Sherman F DNA sequence of a mutation in the leader region of the yeast iso-1-cytochrome c mRNA. Cell. 1981;25(1):277-84 - PMID: 6268305 - DOI: 10.1016/0092-8674(81)90253-1
Orr-Weaver TL, Szostak JW, Rothstein RJ Yeast transformation: a model system for the study of recombination. Proc Natl Acad Sci U S A. 1981;78(10):6354-8 - PMID: 6273866 - PMCID: PMC349037 - DOI: 10.1073/pnas.78.10.6354
Szostak JW, Wu R Unequal crossing over in the ribosomal DNA of Saccharomyces cerevisiae. Nature. 1980;284(5755):426-30 - PMID: 6987539 - DOI: 10.1038/284426a0
Szostak JW, Stiles JI, Tye BK, Chiu P, Sherman F, Wu R Hybridization with synthetic oligonucleotides. Methods Enzymol. 1980;68:419-28 - PMID: 161605 - DOI: 10.1016/0076-6879(79)68031-x
Szostak JW, Wu R Insertion of a genetic marker into the ribosomal DNA of yeast. Plasmid. 1979;2(4):536-54 - PMID: 394173 - DOI: 10.1016/0147-619x(79)90053-2
Szostak JW, Stiles JI, Bahl CP, Wu R Specific binding of a synthetic oligodeoxyribonucleotide to yeast cytochrome c mRNA. Nature. 1977;265(5589):61-3 - PMID: 189200 - DOI: 10.1038/265061a0