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Halvorsen YD, Walford G, Thurber T, Russell H, Massaro M, Freeman MW

A Twelve-Week, Randomized, Double-Blind, Placebo-Controlled, Four-Arm Dose-Finding Phase 2 Study Evaluating Bexagliflozin as a Monotherapy for Adults with Type 2 Diabetes.
Diabetes Obes Metab. 2020;22(4):566-573 - PMID: 31749238 - DOI: 10.1111/dom.13928

Johnson EO, Office E, Kawate T, Orzechowski M, Hung DT

A large-scale chemical-genetic strategy enables design of antimicrobial combination chemotherapy in Mycobacteria.
ACS Infect Dis. 2020;6(1):56-63 - PMID: 31721551 - PMCID: PMC6958538 - DOI: 10.1021/acsinfecdis.9b00373

Zhou L, Kim S, Ho KH, O'Flaherty DK, Giurgiu C, Wright TH, Szostak JW

Non-enzymatic primer extension with strand displacement.
Elife. 2019;8:ePub - PMID: 31702557 - PMCID: PMC6872209 - DOI: 10.7554/eLife.51888

Ogura A, Tsurumi A, Que YA, Almpani M, Zheng H, Tompkins RG, Ryan CM, Rahme LG

Associations between clinical characteristics and the development of multiple organ failure after severe burns in adult patients.
Burns. 2019;45(8):1775-1782 - PMID: 31690472 - DOI: 10.1016/j.burns.2019.02.014

Wang A, Szostak JW

Lipid constituents of model protocell membranes.
Emerg Top Life Sci. 2019;3(5):537-542 - PMID: 33523161 - DOI: 10.1042/ETLS20190021

Maheshwari P, Du H, Sheen J, Assmann SM, Albert R

Model-driven discovery of calcium-related protein-phosphatase inhibition in plant guard cell signaling.
PLoS Comput Biol. 2019;15(10):e1007429 - PMID: 31658257 - PMCID: PMC6837631 - DOI: 10.1371/journal.pcbi.1007429

Wright TH, Giurgiu C, Zhang W, Radakovic A, O'Flaherty DK, Zhou L, Szostak JW

Prebiotically Plausible 'Patching' of RNA Backbone Cleavage Through a 3'-5' Pyrophosphate Linkage.
J Am Chem Soc. 2019;141(45):18104-18112 - PMID: 31651170 - PMCID: PMC7577263 - DOI: 10.1021/jacs.9b08237

Johnson EO, Hung DT

A point of inflection and reflection on systems chemical biology.
ACS Chem Biol. 2019;14(12):2497-2511 - PMID: 31613592 - DOI: 10.1021/acschembio.9b00714

Govindan JA, Jayamani E, Ruvkun G

ROS-based lethality of Caenorhabditis elegans mitochondrial electron transport mutants grown on Escherichia coli siderophore iron release mutants.
Proc Natl Acad Sci U S A. 2019;116(43):21651-21658 - PMID: 31591219 - PMCID: PMC6815122 - DOI: 10.1073/pnas.1912628116

Xu H, Ding J, Porter CBM, Wallrapp A, Tabaka M, Ma S, Fu S, Guo X, Riesenfeld SJ, Su C, Dionne D, Nguyen LT, Lefkovith A, Ashenberg O, Burkett PR, Shi HN, Rozenblatt-Rosen O, Graham DB, Kuchroo VK, Regev A, Xavier RJ

Transcriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide α-CGRP Modulates Group 2 Innate Lymphoid Cell Responses.
Immunity. 2019;51(4):696-708.e9 - PMID: 31618654 - PMCID: PMC6991097 - DOI: 10.1016/j.immuni.2019.09.004

Grünewald J, Zhou R, Iyer S, Lareau CA, Garcia SP, Aryee MJ, Joung JK

CRISPR DNA base editors with reduced RNA off-target and self-editing activities.
Nat Biotechnol. 2019;37(9):1041-1048 - PMID: 31477922 - PMCID: PMC6730565 - DOI: 10.1038/s41587-019-0236-6

Elmaleh DR, Farlow MR, Conti PS, Tompkins RG, Kundakovic L, Tanzi RE

Developing Effective Alzheimer's Disease Therapies: Clinical Experience and Future Directions.
J Alzheimers Dis. 2019;71(3):715-732 - PMID: 31476157 - PMCID: PMC6839593 - DOI: 10.3233/JAD-190507

Khor B, Conway KL, Omar AS, Biton M, Haber AL, Rogel N, Baxt LA, Begun J, Kuballa P, Gagnon JD, Lassen KG, Regev A, Xavier RJ

Distinct Tissue-Specific Roles for the Disease-Associated Autophagy Genes ATG16L2 and ATG16L1.
J Immunol. 2019;203(7):1820-1829 - PMID: 31451676 - PMCID: PMC6761021 - DOI: 10.4049/jimmunol.1800419

Lelyveld VS, O'Flaherty DK, Zhou L, Izgu EC, Szostak JW

DNA polymerase activity on synthetic N3'→P5' phosphoramidate DNA templates.
Nucleic Acids Res. 2019;47(17):8941-8949 - PMID: 31428779 - PMCID: PMC6755091 - DOI: 10.1093/nar/gkz707

Ananthakrishnan AN, Cagan A, Cai T, Gainer VS, Savova G, Shaw SY, Churchill S, Burke KE, Karlson EW, Murphy SN, Kohane I, Liao KP, Xavier RJ

Use of narrative concepts in the EHR to validate genetic determinants of treatment response in a virtual inflammatory bowel disease cohort.
Clin Gastroenterol Hepatol. 2020;18(8):1890-1892 - PMID: 31404664 - PMCID: PMC12476026 - DOI: 10.1016/j.cgh.2019.08.005

Goel G, Tye-Din JA, Qiao SW, Russell AK, Mayassi T, Ciszewski C, Sarna VK, Wang S, Goldstein KE, Dzuris JL, Williams LJ, Xavier RJ, Lundin KEA, Jabri B, Sollid LM, Anderson RP

Cytokine release and gastrointestinal symptoms after gluten challenge in celiac disease.
Sci Adv. 2019;5(8):eaaw7756 - PMID: 31457091 - PMCID: PMC6685723 - DOI: 10.1126/sciadv.aaw7756

Todd ZR, Szabla R, Szostak JW, Sasselov DD

UV photostability of three 2-aminoazoles with key roles in prebiotic chemistry on the early earth.
Chem Commun (Camb). 2019;55(70):10388-10391 - PMID: 31380533 - PMCID: PMC9631353 - DOI: 10.1039/c9cc05265h

Plichta DR, Graham DB, Subramanian S, Xavier RJ

Therapeutic Opportunities in Inflammatory Bowel Disease: Mechanistic Dissection of Host-Microbiome Relationships.
Cell. 2019;178(5):1041-1056 - PMID: 31442399 - PMCID: PMC6778965 - DOI: 10.1016/j.cell.2019.07.045

Kim W, Zou G, Hari TPA, Wilt IK, Zhu W, Galle N, Faizi HA, Hendricks GL, Tori K, Pan W, Huang X, Steele AD, Csatary EE, Dekarske MM, Rosen JL, Ribeiro NQ, Lee K, Port J, Fuchs BB, Vlahovska PM, Wuest WM, Gao H, Ausubel FM, Mylonakis E

A selective membrane-targeting repurposed antibiotic with activity against persistent methicillin-resistant Staphylococcus aureus.
Proc Natl Acad Sci U S A. 2019;116(33):16529-16534 - PMID: 31358625 - PMCID: PMC6697817 - DOI: 10.1073/pnas.1904700116

Mallick H, Franzosa EA, Mclver LJ, Banerjee S, Sirota-Madi A, Kostic AD, Clish CB, Vlamakis H, Xavier RJ, Huttenhower C

Predictive metabolomic profiling of microbial communities using amplicon or metagenomic sequences.
Nat Commun. 2019;10(1):3136 - PMID: 31316056 - PMCID: PMC6637180 - DOI: 10.1038/s41467-019-10927-1

Zhang W, Pal A, Ricardo A, Szostak JW

Template-directed Nonenzymatic Primer Extension Using 2-methylimidazole-activated Morpholino Derivatives of Guanosine and Cytidine.
J Am Chem Soc. 2019;141(30):12159-12166 - PMID: 31298852 - PMCID: PMC7547883 - DOI: 10.1021/jacs.9b06453

Halvorsen YD, Walford GA, Massaro J, Aftring RP, Freeman MW

A 96-Week Multinational Randomized Double-Blind Parallel-Group Clinical Trial Evaluating the Safety and Effectiveness of Bexagliflozin as a Monotherapy for Adults with Type 2 Diabetes.
Diabetes Obes Metab. 2019;21(11):2496-2504 - PMID: 31297965 - DOI: 10.1111/dom.13833

György B, Nist-Lund C, Pan B, Asai Y, Karavitaki KD, Kleinstiver BP, Garcia SP, Zaborowski MP, Solanes P, Spataro S, Schneider BL, Joung JK, Géléoc GSG, Holt JR, Corey DP

Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss.
Nat Med. 2019;25(7):1123-1130 - PMID: 31270503 - PMCID: PMC6802276 - DOI: 10.1038/s41591-019-0500-9

Freeman MW, Singh AK, Guidon AC, Arvikar SL, Goldstein RH, Clement NF

Case 22-2019: A 65-Year-Old Woman with Weakness, Dark Urine, and Dysphagia.
N Engl J Med. 2019;381(3):275-283 - PMID: 31314973 - DOI: 10.1056/NEJMcpc1900589

Smillie CS, Biton M, Ordovas-Montanes J, Sullivan KM, Burgin G, Graham DB, Herbst RH, Rogel N, Slyper M, Waldman J, Sud M, Andrews E, Velonias G, Haber AL, Jagadeesh K, Vickovic S, Yao J, Stevens C, Dionne D, Nguyen LT, Villani AC, Hofree M, Creasey EA, Huang H, Rozenblatt-Rosen O, Garber JJ, Khalili H, Desch AN, Daly MJ, Ananthakrishnan AN, Shalek AK, Xavier RJ, Regev A

Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis.
Cell. 2019;178(3):714-730.e22 - PMID: 31348891 - PMCID: PMC6662628 - DOI: 10.1016/j.cell.2019.06.029
Total: 2489