Burn-induced muscle metabolic derangements and mitochondrial dysfunction are associated with activation of HIF-1α and mTORC1: Role of protein farnesylation.

Nakazawa H, Ikeda K, Shinozaki S, Kobayashi M, Ikegami Y, Fu M, Nakamura T, Yasuhara S, Yu YM, Martyn JAJ, Tompkins RG, Shimokado K, Yorozu T, Ito H, Inoue S, Kaneki M
Sci Rep. 2017;7(1):6618 - PMID: 28747716

Adult-onset, chronic, cyclic thrombocytopenia in a Rhesus macaque (Macaca mulatta) after dengue virus vaccination and viral challenge.

Frydman GH, Metcalf Pate KA, Marini RP, de Laforcade AM, Bosch I, Bakthavatchalu V, Muthupalani S, Swennes AG, Lyons CE, Tompkins RG, Fox JG
Vet Clin Pathol. 2017;:ePub - PMID: 28518476

An Alpha7 Nicotinic Acetylcholine Receptor Agonist (GTS-21) Promotes C2C12 Myonuclear Accretion in Association with Release of Interleukin-6 (IL-6) and Improves Survival in Burned Mice.

Khan MA, Khan MF, Kashiwagi S, Kem WR, Yasuhara S, Kaneki M, Tompkins RG, Martyn JA
Shock. 2017;:ePub - PMID: 28282360

Local and Systemic Changes Associated with Long-term, Percutaneous, Static Implantation of Titanium Alloys in Rhesus Macaques (Macaca mulatta).

Frydman GH, Marini RP, Bakthavatchalu V, Biddle KE, Muthupalani S, Vanderburg CR, Lai B, Bendapudi PK, Tompkins RG, Fox JG
Comp Med. 2017;67(2):165-175 - PMID: 28381317 - PMCID: PMC5402736

iNOS as a Driver of Inflammation and Apoptosis in Mouse Skeletal Muscle after Burn Injury: Possible Involvement of Sirt1 S-Nitrosylation-Mediated Acetylation of p65 NF-?B and p53.

Nakazawa H, Chang K, Shinozaki S, Yasukawa T, Ishimaru K, Yasuhara S, Yu YM, Martyn JA, Tompkins RG, Shimokado K, Kaneki M
PLoS One. 2017;12(1):e0170391 - PMID: 28099528 - PMCID: PMC5242494

Hold the Pendulum: Rates of Acute Kidney Injury are Increased in Patients Who Receive Resuscitation Volumes Less than Predicted by the Parkland Equation.

Mason SA, Nathens AB, Finnerty CC, Gamelli RL, Gibran NS, Arnoldo BD, Tompkins RG, Herndon DN, Jeschke MG,
Ann Surg. 2016;264(6):1142-1147 - PMID: 27828823 - PMCID: PMC5111808

KERIS: kaleidoscope of gene responses to inflammation between species.

Li P, Tompkins RG, Xiao W,
Nucleic Acids Res. 2016;45(D1):D908-D914 - PMID: 27789704 - PMCID: PMC5210651

TNF-?/IL-10 Ratio Correlates with Burn Severity and May Serve as a Risk Predictor of Increased Susceptibility to Infections.

Tsurumi A, Que YA, Ryan CM, Tompkins RG, Rahme LG
Front Public Health. 2016;4:216 - PMID: 27761434 - PMCID: PMC5050217

The metabolic stress response to burn trauma: current understanding and therapies.

Porter C, Tompkins RG, Finnerty CC, Sidossis LS, Suman OE, Herndon DN
Lancet. 2016;388(10052):1417-1426 - PMID: 27707498

Changes in neutrophil migration patterns upon contact with platelets in a microfluidic assay.

Frydman GH, Le A, Ellett F, Jorgensen J, Fox JG, Tompkins RG, Irimia D
J Leukoc Biol. 2016;101(3):797-806 - PMID: 27630219 - PMCID: PMC5295852

Prevention of Burn-Induced Inflammatory Responses and Muscle Wasting By GTS-21, A Specific Agonist for ?7 Nicotinic Acetylcholine Receptors.

Kashiwagi S, Khan MA, Yasuhara S, Goto T, Tompkins RG, Kaneki M, Martyn JA
Shock. 2016;47(1):61-69 - PMID: 27529131 - PMCID: PMC5167674

Molecular Imaging of Smoke-Induced Changes in Nuclear Factor-Kappa B Expression in Murine Tissues Including the Lung.

Syrkina O, Hales CH, Bonab AA, Hamrahi V, Paul K, Jung WJ, Tompkins RG, Fischman AJ, Carter EA
J Burn Care Res. 2016;37(6):335-342 - PMID: 27437954

Coagulation Biomarkers in Healthy Chinese-Origin Rhesus Macaques (Macaca mulatta).

Frydman GH, Bendapudi PK, Marini RP, Vanderburg CR, Tompkins RG, Fox JG
J Am Assoc Lab Anim Sci. 2016;55(3):252-9 - PMID: 27177557 - PMCID: PMC4865685

Role of Elevated Fibrinogen in Burn-Induced Mitochondrial Dysfunction: Protective Effects of Glycyrrhizin.

Ueki R, Liu L, Kashiwagi S, Kaneki M, Khan M, Hirose M, Tompkins RG, Martyn JA, Yasuhara S
Shock. 2016;46(4):382-9 - PMID: 27172157 - PMCID: PMC5026541

Recovery Curves for Pediatric Burn Survivors: Advances in Patient-Oriented Outcomes.

Kazis LE, Lee AF, Rose M, Liang MH, Li NC, Ren XS, Sheridan R, Gilroy-Lewis J, Stoddard F, Hinson M, Warden G, Stubbs K, Blakeney P, Meyer W, McCauley R, Herndon D, Palmieri T, Mooney K, Wood D, Pidcock F, Reilly D, Cullen M, Calvert C, Ryan CM, Schneider JC, Soley-Bori M, Tompkins RG
JAMA Pediatr. 2016;170(6):534-542 - PMID: 26953515

The burn outcome questionnaires: Patient and family reported outcome metrics for children of all ages.

Ryan CM, Cartwright S, Schneider JC, Tompkins RG, Kazis LE
Burns. 2016;42(5):1144-5 - PMID: 26803370

Hold the Pendulum: Rates of Acute Kidney Injury are Increased in Patients Who Receive Resuscitation Volumes Less than Predicted by the Parkland Equation.

Mason SA, Nathens AB, Finnerty CC, Gamelli RL, Gibran NS, Arnoldo BD, Tompkins RG, Herndon DN, Jeschke MG,
Ann Surg. 2016;:ePub - PMID: 26764868

In vivo high-resolution magic angle spinning magnetic and electron paramagnetic resonance spectroscopic analysis of mitochondria-targeted peptide in Drosophila melanogaster with trauma-induced thoracic injury.

Constantinou C, Apidianakis Y, Psychogios N, Righi V, Mindrinos MN, Khan N, Swartz HM, Szeto HH, Tompkins RG, Rahme LG, Tzika AA
Int J Mol Med. 2015;37(2):299-308 - PMID: 26648055 - PMCID: PMC4716799

Quantifying Risk Factors for Long-Term Sleep Problems After Burn Injury in Young Adults.

Lee AF, Ryan CM, Schneider JC, Kazis LE, Li NC, Rose M, Liang MH, Wang C, Palmieri T, Meyer WJ, Pidcock FS, Reilly D, Sheridan RL, Tompkins RG,
J Burn Care Res. 2015;38(2):e510-e520 - PMID: 27003738

Early Leukocyte Gene Expression Associated with Age, Burn Size, and Inhalation Injury in Severely Burned Adults.

Sood RF, Gibran NS, Arnoldo BD, Gamelli RL, Herndon DN, Tompkins RG, Inflammation T, Investigators TH
J Trauma Acute Care Surg. 2015;80(2):250-7 - PMID: 26517785 - PMCID: PMC4731271

Kidney and Liver Injuries After Major Burns in Rats Are Prevented by Resolvin D2.

Inoue Y, Yu YM, Kurihara T, Vasilyev A, Ibrahim A, Oklu R, Zhao G, Nair AV, Brown D, Fischman AJ, Tompkins RG, Irimia D
Crit Care Med. 2015;44(5):e241-52 - PMID: 26509319 - PMCID: PMC4833510

Gene Expression of Proresolving Lipid Mediator Pathways Is Associated With Clinical Outcomes in Trauma Patients.

Orr SK, Butler KL, Hayden D, Tompkins RG, Serhan CN, Irimia D
Crit Care Med. 2015;43(12):2642-2650 - PMID: 26488221 - PMCID: PMC4651815

Is Real-Time Feedback of Burn-Specific Patient-Reported Outcome Measures in Clinical Settings Practical and Useful? A Pilot Study Implementing the Young Adult Burn Outcome Questionnaire.

Ryan CM, Lee AF, Kazis LE, Shapiro GD, Schneider JC, Goverman J, Fagan SP, Wang C, Kim J, Sheridan RL, Tompkins RG
J Burn Care Res. 2015;37(1):64-74 - PMID: 26284638

Do standard burn mortality formulae work on a population of severely burned children and adults?

Tsurumi A, Que YA, Yan S, Tompkins RG, Rahme LG, Ryan CM
Burns. 2015;41(5):935-45 - PMID: 25922299

Genomics of injury: The Glue Grant experience.

Tompkins RG
J Trauma Acute Care Surg. 2015;78(4):671-686 - PMID: 25742245 - PMCID: PMC4389222

Role of Protein Farnesylation in Burn-Induced Metabolic Derangements and Insulin Resistance in Mouse Skeletal Muscle.

Nakazawa H, Yamada M, Tanaka T, Kramer J, Yu YM, Fischman AJ, Martyn JA, Tompkins RG, Kaneki M
PLoS One. 2015;10(1):e0116633 - PMID: 25594415 - PMCID: PMC4296934

Morbidity and Survival Probability in Burn Patients in Modern Burn Care.

Jeschke MG, Pinto R, Kraft R, Nathens AB, Finnerty CC, Gamelli RL, Gibran NS, Klein MB, Arnoldo BD, Tompkins RG, Herndon DN,
Crit Care Med. 2014;43(4):808-15 - PMID: 25559438 - PMCID: PMC4359665

Mice are not men.

Warren HS, Tompkins RG, Moldawer LL, Seok J, Xu W, Mindrinos MN, Maier RV, Xiao W, Davis RW
Proc Natl Acad Sci U S A. 2014;112(4):E345 - PMID: 25540422 - PMCID: PMC4313842

Recovery Trajectories After Burn Injury in Young Adults: Does Burn Size Matter?

Ryan CM, Lee A, Kazis LE, Schneider JC, Shapiro GD, Sheridan RL, Meyer WJ, Palmieri T, Pidcock FS, Reilly D, Tompkins RG,
J Burn Care Res. 2014;36(1):118-29 - PMID: 25501787

Spontaneous Neutrophil Migration Patterns during Sepsis after Major Burns.

Jones CN, Moore M, Dimisko L, Alexander A, Ibrahim A, Hassell BA, Warren HS, Tompkins RG, Fagan SP, Irimia D
PLoS One. 2014;9(12):e114509 - PMID: 25489947 - PMCID: PMC4260850

Effect of exercise on burn-induced changes in tissue-specific glucose metabolism.

Carter EA, Paul K, Bonab AA, Tompkins RG, Fischman AJ
J Burn Care Res. 2014;35(6):470-3 - PMID: 24476988 - PMCID: PMC4113562

Inertial focusing cytometer with integrated optics for particle characterization.

Kotz KT, Petrofsky AC, Haghgooie R, Granier R, Toner M, Tompkins RG
Technology (Singap World Sci). 2014;1(1):27-36 - PMID: 25346940 - PMCID: PMC4206911

Treatment of heterotopic ossification through remote ATP hydrolysis.

Peterson JR, De La Rosa S, Eboda O, Cilwa KE, Agarwal S, Buchman SR, Cederna PS, Xi C, Morris MD, Herndon DN, Xiao W, Tompkins RG, Krebsbach PH, Wang SC, Levi B
Sci Transl Med. 2014;6(255):255ra132 - PMID: 25253675 - PMCID: PMC4353731

Single Hind Limb Burn Injury to Mice Alters Nuclear Factor-?B Expression and [18F] 2-Fluoro-2-Deoxy-D-Glucose Uptake.

Carter EA, Hamrahi V, Paul K, Bonab AA, Jung W, Tompkins RG, Fischman AJ
J Burn Care Res. 2014;35(6):e373-e378 - PMID: 25100541 - PMCID: PMC4229441

Simvastatin Reduces Burn Injury-Induced Splenic Apoptosis via Downregulation of the TNF-?/NF-?B Pathway.

Zhao G, Yu YM, Kaneki M, Bonab AA, Tompkins RG, Fischman AJ
Ann Surg. 2014;261(5):1006-12 - PMID: 24950285 - PMCID: PMC4272342

Prediction of Multiple Infections After Severe Burn Trauma: A Prospective Cohort Study.

Yan S, Tsurumi A, Que YA, Ryan CM, Bandyopadhaya A, Morgan AA, Flaherty PJ, Tompkins RG, Rahme LG
Ann Surg. 2014;261(4):781-792 - PMID: 24950278 - PMCID: PMC4284150

On the Horizon: Research Priorities in Burns for the Next Decade.

Wolf SE, Tompkins RG, Herndon DN
Surg Clin North Am. 2014;94(4):917-930 - PMID: 25085097

Detecting differential protein expression in large-scale population proteomics.

Ryu SY, Qian WJ, Camp DG, Smith RD, Tompkins RG, Davis RW, Xiao W
Bioinformatics. 2014;30(19):2741-6 - PMID: 24928210 - PMCID: PMC4173009

Benchmarking outcomes in the critically injured burn patient.

Klein MB, Goverman J, Hayden DL, Fagan SP, McDonald-Smith GP, Alexander AK, Gamelli RL, Gibran NS, Finnerty CC, Jeschke MG, Arnoldo B, Wispelwey B, Mindrinos MN, Xiao W, Honari SE, Mason PH, Schoenfeld DA, Herndon DN, Tompkins RG,
Ann Surg. 2014;259(5):833-41 - PMID: 24722222 - PMCID: PMC4283803

In vivo high-resolution magic angle spinning proton NMR spectroscopy of Drosophila melanogaster flies as a model system to investigate mitochondrial dysfunction in Drosophila GST2 mutants.

Righi V, Apidianakis Y, Psychogios N, Rahme LG, Tompkins RG, Tzika AA
Int J Mol Med. 2014;34(1):327-33 - PMID: 24789699

Survival From Burns in the New Millennium: 70 Years' Experience From a Single Institution.

Tompkins RG
Ann Surg. 2014;261(2):263-268 - PMID: 24670865 - PMCID: PMC4372065

Long-term posttraumatic stress symptoms vary inversely with early opiate dosing in children recovering from serious burns: Effects durable at 4 years.

Sheridan RL, Stoddard FJ, Kazis LE, Lee A, Li NC, Kagan RJ, Palmieri TL, Meyer WJ, Nicolai M, Stubbs TK, Chan G, Hinson MI, Herndon DN, Tompkins RG,
J Trauma Acute Care Surg. 2014;76(3):828-832 - PMID: 24553556

Membrane potential-dependent uptake of (18)F-triphenylphosphonium-a new voltage sensor as an imaging agent for detecting burn-induced apoptosis.

Zhao G, Yu YM, Shoup TM, Elmaleh DR, Bonab AA, Tompkins RG, Fischman AJ
J Surg Res. 2014;188(2):473-9 - PMID: 24582214 - PMCID: PMC3988254

A Small Volatile Bacterial Molecule Triggers Mitochondrial Dysfunction in Murine Skeletal Muscle.

Tzika AA, Constantinou C, Bandyopadhaya A, Psychogios N, Lee S, Mindrinos M, Martyn JA, Tompkins RG, Rahme LG
PLoS One. 2013;8(9):e74528 - PMID: 24098655 - PMCID: PMC3787027

Reply to Osterburg et al.: To study human inflammatory diseases in humans.

Tompkins RG, Warren HS, Mindrinos MN, Xiao W, Davis RW
Proc Natl Acad Sci U S A. 2013;110(36):E3371 - PMID: 24137798 - PMCID: PMC3767510

Differences in Resuscitation in Morbidly Obese Burn Patients May Contribute to High Mortality.

Rae L, Pham TN, Carrougher G, Honari S, Gibran NS, Arnoldo BD, Gamelli RL, Tompkins RG, Herndon DN
J Burn Care Res. 2013;34(5):507-14 - PMID: 23966116 - PMCID: PMC3800202

Reply to Cauwels et al.: Of men, not mice, and inflammation.

Warren HS, Tompkins RG, Mindrinos MN, Xiao W, Davis RW
Proc Natl Acad Sci U S A. 2013;110(34):E3151 - PMID: 24137663 - PMCID: PMC3752239

Mild Obesity Is Protective After Severe Burn Injury.

Jeschke MG, Finnerty CC, Emdad F, Rivero HG, Kraft R, Williams FN, Gamelli RL, Gibran NS, Klein MB, Arnoldo BD, Tompkins RG, Herndon DN
Ann Surg. 2013;258(6):1119-29 - PMID: 23877367 - PMCID: PMC3963145

Benchmarks for Multidimensional Recovery After Burn Injury in Young Adults: The Development, Validation, and Testing of the American Burn Association/Shriners Hospitals for Children Young Adult Burn Outcome Questionnaire.

Ryan CM, Schneider JC, Kazis LE, Lee A, Li NC, Hinson M, Bauk H, Peck M, Meyer WJ, Palmieri T, Pidcock FS, Reilly D, Tompkins RG,
J Burn Care Res. 2013;34(3):e121-e142 - PMID: 23511284

Trauma-associated Human Neutrophil Alterations Revealed by Comparative Proteomics Profiling.

Zhou JY, Krovvidi RK, Gao Y, Gao H, Petritis BO, De A, Miller-Graziano C, Bankey PE, Petyuk VA, Nicora CD, Clauss TR, Moore RJ, Shi T, Brown JN, Kaushal A, Xiao W, Davis RW, Maier RV, Tompkins RG, Qian WJ, Camp DG, Smith RD,
Proteomics Clin Appl. 2013;7(7-8):571-83 - PMID: 23589343 - PMCID: PMC3737403

Mitochondria-targeted antioxidant promotes recovery of skeletal muscle mitochondrial function after burn trauma assessed by in vivo 31P nuclear magnetic resonance and electron paramagnetic resonance spectroscopy.

Righi V, Constantinou C, Mintzopoulos D, Khan N, Mupparaju SP, Rahme LG, Swartz HM, Szeto HH, Tompkins RG, Tzika AA
FASEB J. 2013;27(6):2521-30 - PMID: 23482635 - PMCID: PMC3659352

Efficacy of Phosphodiesterase 5 inhibitor on distant burn-induced muscle autophagy, microcirculation and survival rate.

Hosokawa S, Nagashima M, Maeyama Y, Koseki H, Yomogida K, Mehr C, Rutledge M, Greenfeld H, Kaneki M, Tompkins RG, Martyn JJ, Yasuhara SE
Am J Physiol Endocrinol Metab. 2013;304(9):E922-33 - PMID: 23512808

Evaluation of Intragastric Vs Intraperitoneal Glucose Tolerance Tests in the Evaluation of Insulin Resistance in a Rodent Model of Burn Injury and Glucagon-Like Polypeptide-1 Treatment.

Watada S, Yu YM, Fischman AJ, Kurihara T, Shen CA, Tompkins RG, Fagan S
J Burn Care Res. 2013;35(1):e66-72 - PMID: 23511296 - PMCID: PMC4053788

Determination of Burn Patient Outcome by Large-Scale Quantitative Discovery Proteomics.

Finnerty CC, Jeschke MG, Qian WJ, Kaushal A, Xiao W, Liu T, Gritsenko MA, Moore RJ, Camp DG, Moldawer LL, Elson C, Schoenfeld D, Gamelli R, Gibran N, Klein M, Arnoldo B, Remick D, Smith RD, Davis R, Tompkins RG, Herndon DN,
Crit Care Med. 2013;41(6):1421-1434 - PMID: 23507713 - PMCID: PMC3660437

Resolvin D2 restores neutrophil directionality and improves survival after burns.

Kurihara T, Jones CN, Yu YM, Fischman AJ, Watada S, Tompkins RG, Fagan SP, Irimia D
FASEB J. 2013;27(6):2270-81 - PMID: 23430978 - PMCID: PMC3659356

Genomic responses in mouse models poorly mimic human inflammatory diseases.

Seok J, Warren HS, Cuenca AG, Mindrinos MN, Baker HV, Xu W, Richards DR, McDonald-Smith GP, Gao H, Hennessy L, Finnerty CC, López CM, Honari S, Moore EE, Minei JP, Cuschieri J, Bankey PE, Johnson JL, Sperry J, Nathens AB, Billiar TR, West MA, Jeschke MG, Klein MB, Gamelli RL, Gibran NS, Brownstein BH, Miller-Graziano C, Calvano SE, Mason PH, Cobb JP, Rahme LG, Lowry SF, Maier RV, Moldawer LL, Herndon DN, Davis RW, Xiao W, Tompkins RG,
Proc Natl Acad Sci U S A. 2013;110(9):3507-12 - PMID: 23401516 - PMCID: PMC3587220

Development of a Genomic Metric That Can Be Rapidly Used to Predict Clinical Outcome in Severely Injured Trauma Patients.

Cuenca AG, Gentile LF, Lopez MC, Ungaro R, Liu H, Xiao W, Seok J, Mindrinos MN, Ang D, Ozrazgat Baslanti T, Bihorac A, Efron PA, Cuschieri J, Warren HS, Tompkins RG, Maier RV, Baker HV, Moldawer LL,
Crit Care Med. 2013;41(5):1175-1185 - PMID: 23388514 - PMCID: PMC3652285

Burn injury-induced IRS-1 degradation in mouse skeletal muscle.

Lu XM, Tompkins R, Fischman A
Int J Burns Trauma. 2013;3(1):37-48 - PMID: 23386984 - PMCID: PMC3560490

Nitric oxide activates intradomain disulfide bond formation in the kinase loop of Akt1/PKB? after burn injury.

Lu XM, Tompkins RG, Fischman AJ
Int J Mol Med. 2013;31(3):740-50 - PMID: 23314241 - PMCID: PMC3597556

Simvastatin Protects Hepatocytes From Apoptosis by Suppressing the TNF-?/Caspase-3 Signaling Pathway in Mice With Burn Injury.

Zhao G, Yu YM, Kaneki M, Tompkins RG, Fischman AJ
Ann Surg. 2012;257(6):1129-36 - PMID: 23275311 - PMCID: PMC4102342

Brown Adipose Tissue and Its Modulation by a Mitochondria-targeted Peptide in Rat Burn Injury Induced Hypermetabolism.

Yo K, Yu YM, Zhao G, Bonab AA, Aikawa N, Tompkins RG, Fischman AJ
Am J Physiol Endocrinol Metab. 2012;304(4):E331-41 - PMID: 23169784 - PMCID: PMC3566510

Combination of Radiation and Burn Injury Alters [18F] 2-Fluoro-2-Deoxy-D-Glucose Uptake in Mice.

Carter EA, Winter D, Tolman C, Paul K, Hamrahi V, Tompkins RG, Fischman AJ
J Burn Care Res. 2012;33(6):723-30 - PMID: 23143615 - PMCID: PMC3673011

Imaging C-Fos Gene Expression in Burns Using Lipid Coated Spion Nanoparticles.

Papagiannaros A, Righi V, Day GG, Rahme LG, Liu PK, Fischman AJ, Tompkins RG, Tzika AA
Adv J Mol Imaging. 2012;2(4):31-37 - PMID: 24995147 - PMCID: PMC4076698

Measuring the cost of care for children with acute burn injury.

Carey K, Kazis LE, Lee AF, Liang MH, Li NC, Hinson MI, Lydon MK, Bauk H, Shapiro GD, Tompkins RG,
J Trauma Acute Care Surg. 2012;73(3 Suppl 2):S229-33 - PMID: 22929551

Impact of hand burns on health-related quality of life in children younger than 5 years.

Palmieri TL, Nelson-Mooney K, Kagan RJ, Stubbs TK, Meyer WJ, Herndon DN, Hinson MI, Lee AF, Li NC, Kazis LE, Tompkins RG,
J Trauma Acute Care Surg. 2012;73(3 Suppl 2):S197-204 - PMID: 22929547

The American Burn Association/Shriners Hospitals for Children Burn Outcomes Program: A progress report at 15 years.

Tompkins RG, Liang MH, Lee AF, Kazis LE,
J Trauma Acute Care Surg. 2012;73(3 Suppl 2):S173-8 - PMID: 22929544

Previous burn injury predisposes mice to lipopolysaccharide-induced changes in glucose metabolism.

Carter EA, Paul KW, Barrow SA, Fischman AJ, Tompkins RG
J Burn Care Res. 2012;33(5):683-9 - PMID: 22961012 - PMCID: PMC3441057

Gram-Negative Bacterial Infection in Thigh Abscess Can Migrate to Distant Burn Depending on Burn Depth.

Hamrahi V, Hamblin MR, Jung W, Benjamin JB, Paul KW, Fischman AJ, Tompkins RG, Carter EA
Interdiscip Perspect Infect Dis. 2012;2012:567140 - PMID: 22899912 - PMCID: PMC3412104

In vivo molecular imaging of murine embryonic stem cells delivered to a burn wound surface via Integra® scaffolding.

Hamrahi VF, Goverman J, Jung W, Wu JC, Fischman AJ, Tompkins RG, Yu YY, Fagan SP, Carter EA
J Burn Care Res. 2012;33(2):e49-54 - PMID: 22540138 - PMCID: PMC3311992

The changing pattern and implications of multiple organ failure after blunt injury with hemorrhagic shock*

Minei JP, Cuschieri J, Sperry J, Moore EE, West MA, Harbrecht BG, O'Keefe GE, Cohen MJ, Moldawer LL, Tompkins RG, Maier RV
Crit Care Med. 2012;40(4):1129-1135 - PMID: 22020243 - PMCID: PMC3343366

Benchmarking Outcomes in the Critically Injured Trauma Patient and the Effect of Implementing Standard Operating Procedures.

Cuschieri J, Johnson JL, Sperry J, West MA, Moore EE, Minei JP, Bankey PE, Nathens AB, Cuenca AG, Efron PA, Hennessy L, Xiao W, Mindrinos MN, McDonald-Smith GP, Mason PH, Billiar TR, Schoenfeld DA, Warren HS, Cobb JP, Moldawer LL, Davis RW, Maier RV, Tompkins RG,
Ann Surg. 2012;255(5):993-9 - PMID: 22470077 - PMCID: PMC3327791

Integration of architectural and cytologic driven image algorithms for prostate adenocarcinoma identification.

Hipp J, Monaco J, Kunju LP, Cheng J, Yagi Y, Rodriguez-Canales J, Emmert-Buck MR, Hewitt S, Feldman MD, Tomaszewski JE, Toner M, Tompkins RG, Flotte T, Lucas D, Gilbertson JR, Madabhushi A, Balis U
Anal Cell Pathol (Amst). 2012;35(4):251-65 - PMID: 22425661 - PMCID: PMC4605585

Glucose metabolism during the early after burn injury.

Xu H, Yu YM, Ma H, Carter EA, Fagan S, Tompkins RG, Fischman AJ
J Surg Res. 2012;179(1):e83-90 - PMID: 22459295 - PMCID: PMC4074901

In Vivo Molecular Imaging of Murine Embryonic Stem Cells Delivered to a Burn Wound Surface via Integra® Scaffolding.

Hamrahi VF, Goverman J, Jung W, Wu JC, Fischman AJ, Tompkins RG, Yu YY, Fagan SP, Carter EA
J Burn Care Res. 2012;33(2):e49-54 - PMID: 22441149 - PMCID: PMC3311992

Severe injury is associated with insulin resistance, endoplasmic reticulum stress response, and unfolded protein response.

Jeschke MG, Finnerty CC, Herndon DN, Song J, Boehning D, Tompkins RG, Baker HV, Gauglitz GG
Ann Surg. 2012;255(2):370-8 - PMID: 22241293 - PMCID: PMC3395076

Survival of children with burn injuries.

Tompkins RG
Lancet. 2012;379(9820):983-4 - PMID: 22296811 - PMCID: PMC4019221

Thermal Injury Activates eEF2k-Dependent eEF2 Pathway in Pediatric Patients.

Song J, Finnerty CC, Herndon DN, Kraft R, Boehning D, Brooks NC, Tompkins RG, Jeschke MG
JPEN J Parenter Enteral Nutr. 2012;36(5):596-602 - PMID: 22269896 - PMCID: PMC3580832

Incidence of Catheter-Associated Bloodstream Infection After Introduction of Minocycline and Rifampin Antimicrobial-Coated Catheters in a Pediatric Burn Population.

Weber JM, Sheridan RL, Fagan S, Ryan CM, Pasternack MS, Tompkins RG
J Burn Care Res. 2012;33(4):539-43 - PMID: 22210071

SILAM for quantitative proteomics of liver Akt1/PKB? after burn injury.

Lu XM, Tompkins RG, Fischman AJ
Int J Mol Med. 2011;29(3):461-71 - PMID: 22179310 - PMCID: PMC3981641

Novel mitochondria-targeted antioxidant peptide ameliorates burn-induced apoptosis and endoplasmic reticulum stress in the skeletal muscle of mice.

Lee HY, Kaneki M, Andreas J, Tompkins RG, Martyn JA
Shock. 2011;36(6):580-5 - PMID: 21937949 - PMCID: PMC3230221

A genomic storm in critically injured humans.

Xiao W, Mindrinos MN, Seok J, Cuschieri J, Cuenca AG, Gao H, Hayden DL, Hennessy L, Moore EE, Minei JP, Bankey PE, Johnson JL, Sperry J, Nathens AB, Billiar TR, West MA, Brownstein BH, Mason PH, Baker HV, Finnerty CC, Jeschke MG, López MC, Klein MB, Gamelli RL, Gibran NS, Arnoldo B, Xu W, Zhang Y, Calvano SE, McDonald-Smith GP, Schoenfeld DA, Storey JD, Cobb JP, Warren HS, Moldawer LL, Herndon DN, Lowry SF, Maier RV, Davis RW, Tompkins RG,
J Exp Med. 2011;208(13):2581-90 - PMID: 22110166 - PMCID: PMC3244029

Down-regulation of glutatione S-transferase ? 4 (hGSTA4) in the muscle of thermally injured patients is indicative of susceptibility to bacterial infection.

Apidianakis Y, Que YA, Xu W, Tegos GP, Zimniak P, Hamblin MR, Tompkins RG, Xiao W, Rahme LG
FASEB J. 2011;26(2):730-7 - PMID: 22038048 - PMCID: PMC3290433

Microfluidics-based capture of human neutrophils for expression analysis in blood and bronchoalveolar lavage.

Warner EA, Kotz KT, Ungaro RF, Abouhamze AS, Lopez MC, Cuenca AG, Kelly-Scumpia KM, Moreno C, O'Malley KA, Lanz JD, Baker HV, Martin LC, Toner M, Tompkins RG, Efron PA, Moldawer LL
Lab Invest. 2011;91(12):1787-95 - PMID: 21931299 - PMCID: PMC3957199

Dissecting inflammatory complications in critically injured patients by within-patient gene expression changes: a longitudinal clinical genomics study.

Desai KH, Tan CS, Leek JT, Maier RV, Tompkins RG, Storey JD,
PLoS Med. 2011;8(9):e1001093 - PMID: 21931541 - PMCID: PMC3172280

Association of heat production with 18F-FDG accumulation in murine brown adipose tissue after stress.

Carter EA, Bonab AA, Paul K, Yerxa J, Tompkins RG, Fischman AJ
J Nucl Med. 2011;52(10):1616-20 - PMID: 21914754 - PMCID: PMC4082963

Patterns of medication administration from 2001 to 2009 in the treatment of children with acute burn injuries: a multicenter study.

Stoddard FJ, White GW, Kazis LE, Murphy JM, Sorrentino EA, Hinson M, Kim Stubbs T, Chan G, Sheridan RL, Palmieri T, Kagan R, Herndon D, Tompkins RG
J Burn Care Res. 2011;32(5):519-28 - PMID: 21811176

Considerations for preparedness for a pediatric burn disaster.

Ryan CM, Antoon A, Fagan SP, Goverman J, Lawlor D, Sheridan RL, Tompkins RG
J Burn Care Res. 2011;32(5):e165-6 - PMID: 21772149

The Glue Grant experience: characterizing the post injury genomic response.

Cuenca AG, Maier RV, Cuschieri J, Moore EE, Moldawer LL, Tompkins RG,
Eur J Trauma Emerg Surg. 2011;37(6):549-58 - PMID: 26815465

Farnesyltransferase inhibitor FTI-277 reduces mortality of septic mice along with improved bacterial clearance.

Yang W, Yamada M, Tamura Y, Chang K, Mao J, Zou L, Feng Y, Kida K, Scherrer-Crosbie M, Chao W, Ichinose F, Yu YM, Fischman AJ, Tompkins RG, Yao S, Kaneki M
J Pharmacol Exp Ther. 2011;339(3):832-41 - PMID: 21873557 - PMCID: PMC3226365

Evaluation of the antioxidant peptide SS31 for treatment of burn-induced insulin resistance.

Carter EA, Bonab AA, Goverman J, Paul K, Yerxa J, Tompkins RG, Fischman AJ
Int J Mol Med. 2011;28(4):589-94 - PMID: 21805045 - PMCID: PMC4090514

Computer aided diagnostic tools aim to empower rather than replace pathologists: Lessons learned from computational chess.

Hipp J, Flotte T, Monaco J, Cheng J, Madabhushi A, Yagi Y, Rodriguez-Canales J, Emmert-Buck M, Dugan MC, Hewitt S, Toner M, Tompkins RG, Lucas D, Gilbertson JR, Balis UJ
J Pathol Inform. 2011;2:25 - PMID: 21773056 - PMCID: PMC3132993

Effects of burn injury, cold stress and cutaneous wound injury on the morphology and energy metabolism of murine brown adipose tissue (BAT) in vivo.

Carter EA, Bonab AA, Hamrahi V, Pitman J, Winter D, Macintosh LJ, Cyr EM, Paul K, Yerxa J, Jung W, Tompkins RG, Fischman AJ
Life Sci. 2011;89(3-4):78-85 - PMID: 21565200 - PMCID: PMC4081480

Isolation and long-term maintenance of adult rat hepatocytes in culture.

Berthiaume F, Tompkins RG, Yarmush ML
Methods Mol Med. 2011;18:447-56 - PMID: 21370195

Spatially Invariant Vector Quantization: A pattern matching algorithm for multiple classes of image subject matter including pathology.

Hipp JD, Cheng JY, Toner M, Tompkins RG, Balis UJ
J Pathol Inform. 2011;2:13 - PMID: 21383936 - PMCID: PMC3049270

Human transcriptome array for high-throughput clinical studies.

Xu W, Seok J, Mindrinos MN, Schweitzer AC, Jiang H, Wilhelmy J, Clark TA, Kapur K, Xing Y, Faham M, Storey JD, Moldawer LL, Maier RV, Tompkins RG, Wong WH, Davis RW, Xiao W,
Proc Natl Acad Sci U S A. 2011;108(9):3707-12 - PMID: 21317363 - PMCID: PMC3048146

Effects of glucagon-like peptide 1 on glycemia control and its metabolic consequence after severe thermal injury--studies in an animal model.

Shen CA, Fagan S, Fischman AJ, Carter EE, Chai JK, Lu XM, Yu YM, Tompkins RG
Surgery. 2011;149(5):635-44 - PMID: 21295809 - PMCID: PMC3079016

Microfluidics for T- lymphocyte cell separation and inflammation monitoring in burn patients.

Rosenbach AE, Koria P, Goverman J, Kotz KT, Gupta A, Yu M, Fagan SP, Irimia D, Tompkins RG
Clin Transl Sci. 2011;4(1):63-8 - PMID: 21348958 - PMCID: PMC3057059

Early enteral nutrition in burns: compliance with guidelines and associated outcomes in a multicenter study.

Mosier MJ, Pham TN, Klein MB, Gibran NS, Arnoldo BD, Gamelli RL, Tompkins RG, Herndon DN
J Burn Care Res. 2011;32(1):104-9 - PMID: 21116188 - PMCID: PMC3850279

Simvastatin treatment improves survival in a murine model of burn sepsis: Role of interleukin 6.

Beffa DC, Fischman AJ, Fagan SP, Hamrahi VF, Paul KW, Kaneki M, Yu YM, Tompkins RG, Carter EA
Burns. 2010;37(2):222-6 - PMID: 21145172 - PMCID: PMC4085785

The contribution of muscle to whole-body protein turnover throughout the course of burn injury in children.

Prelack K, Yu YM, Dylewski M, Lydon M, Sheridan RL, Tompkins RG
J Burn Care Res. 2010;31(6):942-8 - PMID: 21105320 - PMCID: PMC4084779

Stem cells and burns: review and therapeutic implications.

Butler KL, Goverman J, Ma H, Fischman A, Yu YM, Bilodeau M, Rad AM, Bonab AA, Tompkins RG, Fagan SP
J Burn Care Res. 2010;31(6):874-81 - PMID: 20859216

Plasma proteome response to severe burn injury revealed by 18O-labeled "universal" reference-based quantitative proteomics.

Qian WJ, Petritis BO, Kaushal A, Finnerty CC, Jeschke MG, Monroe ME, Moore RJ, Schepmoes AA, Xiao W, Moldawer LL, Davis RW, Tompkins RG, Herndon DN, Camp DG, Smith RD,
J Proteome Res. 2010;9(9):4779-89 - PMID: 20698492 - PMCID: PMC2945297

Effect of simvastatin on burn-induced alterations in tissue specific glucose metabolism: implications for burn associated insulin resistance.

Bonab AA, Carter EA, Paul K, Kaneki M, Yu YM, Tompkins RG, Fischman AJ
Int J Mol Med. 2010;26(3):311-6 - PMID: 20664945 - PMCID: PMC4090513

Clinical microfluidics for neutrophil genomics and proteomics.

Kotz KT, Xiao W, Miller-Graziano C, Qian WJ, Russom A, Warner EA, Moldawer LL, De A, Bankey PE, Petritis BO, Camp DG, Rosenbach AE, Goverman J, Fagan SP, Brownstein BH, Irimia D, Xu W, Wilhelmy J, Mindrinos MN, Smith RD, Davis RW, Tompkins RG, Toner M,
Nat Med. 2010;16(9):1042-7 - PMID: 20802500 - PMCID: PMC3136804

Burn injury reduces neutrophil directional migration speed in microfluidic devices.

Butler KL, Ambravaneswaran V, Agrawal N, Bilodeau M, Toner M, Tompkins RG, Fagan S, Irimia D
PLoS One. 2010;5(7):e11921 - PMID: 20689600 - PMCID: PMC2912851

Reactive bone marrow stromal cells attenuate systemic inflammation via sTNFR1.

Yagi H, Soto-Gutierrez A, Navarro-Alvarez N, Nahmias Y, Goldwasser Y, Kitagawa Y, Tilles AW, Tompkins RG, Parekkadan B, Yarmush ML
Mol Ther. 2010;18(10):1857-64 - PMID: 20664529 - PMCID: PMC2951565

Bone marrow mesenchymal stromal cells attenuate organ injury induced by LPS and burn.

Yagi H, Soto-Gutierrez A, Kitagawa Y, Tilles AW, Tompkins RG, Yarmush ML
Cell Transplant. 2010;19(6):823-30 - PMID: 20573305 - PMCID: PMC2957544

Mesenchymal stem cells: Mechanisms of immunomodulation and homing.

Yagi H, Soto-Gutierrez A, Parekkadan B, Kitagawa Y, Tompkins RG, Kobayashi N, Yarmush ML
Cell Transplant. 2010;19(6):667-79 - PMID: 20525442 - PMCID: PMC2957533

Isolation and characterization of circulating tumor cells from patients with localized and metastatic prostate cancer.

Stott SL, Lee RJ, Nagrath S, Yu M, Miyamoto DT, Ulkus L, Inserra EJ, Ulman M, Springer S, Nakamura Z, Moore AL, Tsukrov DI, Kempner ME, Dahl DM, Wu CL, Iafrate AJ, Smith MR, Tompkins RG, Sequist LV, Toner M, Haber DA, Maheswaran S
Sci Transl Med. 2010;2(25):25ra23 - PMID: 20424012 - PMCID: PMC3141292

Early acute kidney injury predicts progressive renal dysfunction and higher mortality in severely burned adults.

Mosier MJ, Pham TN, Klein MB, Gibran NS, Arnoldo BD, Gamelli RL, Tompkins RG, Herndon DN
J Burn Care Res. 2010;31(1):83-92 - PMID: 20061841 - PMCID: PMC3045668

Long-term superior performance of a stem cell/hepatocyte device for the treatment of acute liver failure.

Yagi H, Parekkadan B, Suganuma K, Soto-Gutierrez A, Tompkins RG, Tilles AW, Yarmush ML
Tissue Eng Part A. 2009;15(11):3377-88 - PMID: 19397469 - PMCID: PMC2792056

Validation of the riboleukogram to detect ventilator-associated pneumonia after severe injury.

Cobb JP, Moore EE, Hayden DL, Minei JP, Cuschieri J, Yang J, Li Q, Lin N, Brownstein BH, Hennessy L, Mason PH, Schierding WS, Dixon DJ, Tompkins RG, Warren HS, Schoenfeld DA, Maier RV
Ann Surg. 2009;250(4):531-9 - PMID: 19730236 - PMCID: PMC3047595

Effect of insulin levels on the phosphorylation of specific amino acid residues in IRS-1: implications for burn-induced insulin resistance.

Lu XM, Hamrahi VF, Tompkins RG, Fischman AJ
Int J Mol Med. 2009;24(4):531-8 - PMID: 19724894 - PMCID: PMC4084762

Preliminary evidence for the effects of morphine on posttraumatic stress disorder symptoms in one- to four-year-olds with burns.

Stoddard FJ, Sorrentino EA, Ceranoglu TA, Saxe G, Murphy JM, Drake JE, Ronfeldt H, White GW, Kagan J, Snidman N, Sheridan RL, Tompkins RG
J Burn Care Res. 2009;30(5):836-43 - PMID: 19692914

Microarray analysis suggests that burn injury results in mitochondrial dysfunction in human skeletal muscle.

Tzika AA, Mintzopoulos D, Mindrinos M, Zhang J, Rahme LG, Tompkins RG
Int J Mol Med. 2009;24(3):387-92 - PMID: 19639232 - PMCID: PMC3207251

A genomic score prognostic of outcome in trauma patients.

Warren HS, Elson CM, Hayden DL, Schoenfeld DA, Cobb JP, Maier RV, Moldawer LL, Moore EE, Harbrecht BG, Pelak K, Cuschieri J, Herndon DN, Jeschke MG, Finnerty CC, Brownstein BH, Hennessy L, Mason PH, Tompkins RG,
Mol Med. 2009;15(7-8):220-7 - PMID: 19593405 - PMCID: PMC2707513

Regulation of signaling pathways downstream of IGF-I/insulin by androgen in skeletal muscle of glucocorticoid-treated rats.

Yin HN, Chai JK, Yu YM, Shen CA, Wu YQ, Yao YM, Liu H, Liang LM, Tompkins RG, Sheng ZY
J Trauma. 2009;66(4):1083-90 - PMID: 19359918 - PMCID: PMC4085982

Enhancing the performance of a point-of-care CD4+ T-cell counting microchip through monocyte depletion for HIV/AIDS diagnostics.

Cheng X, Gupta A, Chen C, Tompkins RG, Rodriguez W, Toner M
Lab Chip. 2009;9(10):1357-64 - PMID: 19417901 - PMCID: PMC4064257

Are topical antimicrobials effective against bacteria that are highly resistant to systemic antibiotics?

Neely AN, Gardner J, Durkee P, Warden GD, Greenhalgh DG, Gallagher JJ, Herndon DN, Tompkins RG, Kagan RJ
J Burn Care Res. 2009;30(1):19-29 - PMID: 19060725

Large-scale multiplexed quantitative discovery proteomics enabled by the use of an (18)O-labeled "universal" reference sample.

Qian WJ, Liu T, Petyuk VA, Gritsenko MA, Petritis BO, Polpitiya AD, Kaushal A, Xiao W, Finnerty CC, Jeschke MG, Jaitly N, Monroe ME, Moore RJ, Moldawer LL, Davis RW, Tompkins RG, Herndon DN, Camp DG, Smith RD,
J Proteome Res. 2009;8(1):290-9 - PMID: 19053531 - PMCID: PMC2752204

Genome-wide transcriptome analysis of 150 cell samples.

Irimia D, Mindrinos M, Russom A, Xiao W, Wilhelmy J, Wang S, Heath JD, Kurn N, Tompkins RG, Davis RW, Toner M
Integr Biol (Camb). 2008;1(1):99-107 - PMID: 20023796 - PMCID: PMC3763906

Impact of oxandrolone treatment on acute outcomes after severe burn injury.

Pham TN, Klein MB, Gibran NS, Arnoldo BD, Gamelli RL, Silver GM, Jeschke MG, Finnerty CC, Tompkins RG, Herndon DN
J Burn Care Res. 2008;29(6):902-6 - PMID: 18849836 - PMCID: PMC3958934

A microfluidics approach for the isolation of nucleated red blood cells (NRBCs) from the peripheral blood of pregnant women.

Huang R, Barber TA, Schmidt MA, Tompkins RG, Toner M, Bianchi DW, Kapur R, Flejter WL
Prenat Diagn. 2008;28(10):892-9 - PMID: 18821715 - PMCID: PMC4482103

Temporal cytokine profiles in severely burned patients: a comparison of adults and children.

Finnerty CC, Jeschke MG, Herndon DN, Gamelli R, Gibran N, Klein M, Silver G, Arnoldo B, Remick D, Tompkins RG,
Mol Med. 2008;14(9-10):553-60 - PMID: 18548133 - PMCID: PMC2424320

Detection of mutations in EGFR in circulating lung-cancer cells.

Maheswaran S, Sequist LV, Nagrath S, Ulkus L, Brannigan B, Collura CV, Inserra E, Diederichs S, Iafrate AJ, Bell DW, Digumarthy S, Muzikansky A, Irimia D, Settleman J, Tompkins RG, Lynch TJ, Toner M, Haber DA
N Engl J Med. 2008;359(4):366-77 - PMID: 18596266 - PMCID: PMC3551471

Early supplemental parenteral nutrition is associated with increased infectious complications in critically ill trauma patients.

Sena MJ, Utter GH, Cuschieri J, Maier RV, Tompkins RG, Harbrecht BG, Moore EE, O'Keefe GE
J Am Coll Surg. 2008;207(4):459-67 - PMID: 18926446 - PMCID: PMC4002002

Murine intramyocellular lipids quantified by NMR act as metabolic biomarkers in burn trauma.

Tzika AA, Astrakas LG, Cao H, Mintzopoulos D, Zhang Q, Padfield K, Yu H, Mindrinos MN, Rahme LG, Tompkins RG
Int J Mol Med. 2008;21(6):825-32 - PMID: 18506378

Estimating glutathione synthesis with deuterated water: a model for peptide biosynthesis.

Cabral CB, Bullock KH, Bischoff DJ, Tompkins RG, Yu YM, Kelleher JK
Anal Biochem. 2008;379(1):40-4 - PMID: 18486587 - PMCID: PMC4065382

Increased uncoupling protein 1 mRNA expression in mice brown adipose tissue after burn injury.

Zhang Q, Ma B, Fischman AJ, Tompkins RG, Carter EA
J Burn Care Res. 2008;29(2):358-62 - PMID: 18354294

Burn-related metabolic and signaling changes in rat brain.

Zhang Q, Carter EA, Ma B, Fischman AJ, Tompkins RG
J Burn Care Res. 2008;29(2):346-52 - PMID: 18354292

Microfluidic leukocyte isolation for gene expression analysis in critically ill hospitalized patients.

Russom A, Sethu P, Irimia D, Mindrinos MN, Calvano SE, Garcia I, Finnerty C, Tannahill C, Abouhamze A, Wilhelmy J, López MC, Baker HV, Herndon DN, Lowry SF, Maier RV, Davis RW, Moldawer LL, Tompkins RG, Toner M,
Clin Chem. 2008;54(5):891-900 - PMID: 18375483 - PMCID: PMC4011019

Equilibrium separation and filtration of particles using differential inertial focusing.

Di Carlo D, Edd JF, Irimia D, Tompkins RG, Toner M
Anal Chem. 2008;80(6):2204-11 - PMID: 18275222

Invention, innovation, entrepreneurship in academic medical centers.

Toner M, Tompkins RG
Surgery. 2008;143(2):168-71 - PMID: 18242329 - PMCID: PMC2408552

Reduced rate of adenosine triphosphate synthesis by in vivo 31P nuclear magnetic resonance spectroscopy and downregulation of PGC-1beta in distal skeletal muscle following burn.

Tzika AA, Mintzopoulos D, Padfield K, Wilhelmy J, Mindrinos MN, Yu H, Cao H, Zhang Q, Astrakas LG, Zhang J, Yu YM, Rahme LG, Tompkins RG
Int J Mol Med. 2008;21(2):201-8 - PMID: 18204786

Involvement of skeletal muscle gene regulatory network in susceptibility to wound infection following trauma.

Apidianakis Y, Mindrinos MN, Xiao W, Tegos GP, Papisov MI, Hamblin MR, Davis RW, Tompkins RG, Rahme LG
PLoS One. 2007;2(12):e1356 - PMID: 18159239 - PMCID: PMC2131783

American Burn Association consensus conference to define sepsis and infection in burns.

Greenhalgh DG, Saffle JR, Holmes JH, Gamelli RL, Palmieri TL, Horton JW, Tompkins RG, Traber DL, Mozingo DW, Deitch EA, Goodwin CW, Herndon DN, Gallagher JJ, Sanford AP, Jeng JC, Ahrenholz DH, Neely AN, O'Mara MS, Wolf SE, Purdue GF, Garner WL, Yowler CJ, Latenser BA,
J Burn Care Res. 2007;28(6):776-90 - PMID: 17925660

Isolation of rare circulating tumour cells in cancer patients by microchip technology.

Nagrath S, Sequist LV, Maheswaran S, Bell DW, Irimia D, Ulkus L, Smith MR, Kwak EL, Digumarthy S, Muzikansky A, Ryan P, Balis UJ, Tompkins RG, Haber DA, Toner M
Nature. 2007;450(7173):1235-9 - PMID: 18097410 - PMCID: PMC3090667

Continuous inertial focusing, ordering, and separation of particles in microchannels.

Di Carlo D, Irimia D, Tompkins RG, Toner M
Proc Natl Acad Sci U S A. 2007;104(48):18892-7 - PMID: 18025477 - PMCID: PMC2141878

L-arginine attenuates acute lung injury after smoke inhalation and burn injury in sheep.

Murakami K, Enkhbaatar P, Yu YM, Traber LD, Cox RA, Hawkins HK, Tompkins RG, Herndon D, Traber DL
Shock. 2007;28(4):477-83 - PMID: 17558346

Inhibitors of pathogen intercellular signals as selective anti-infective compounds.

Lesic B, Lépine F, Déziel E, Zhang J, Zhang Q, Padfield K, Castonguay MH, Milot S, Stachel S, Tzika AA, Tompkins RG, Rahme LG
PLoS Pathog. 2007;3(9):1229-39 - PMID: 17941706 - PMCID: PMC2323289

A microchip approach for practical label-free CD4+ T-cell counting of HIV-infected subjects in resource-poor settings.

Cheng X, Irimia D, Dixon M, Ziperstein JC, Demirci U, Zamir L, Tompkins RG, Toner M, Rodriguez WR
J Acquir Immune Defic Syndr. 2007;45(3):257-61 - PMID: 17414933

The association between fluid administration and outcome following major burn: a multicenter study.

Klein MB, Hayden D, Elson C, Nathens AB, Gamelli RL, Gibran NS, Herndon DN, Arnoldo B, Silver G, Schoenfeld D, Tompkins RG
Ann Surg. 2007;245(4):622-8 - PMID: 17414612 - PMCID: PMC1877030

Standard operating procedures for the clinical management of patients enrolled in a prospective study of Inflammation and the Host Response to Thermal Injury.

Silver GM, Klein MB, Herndon DN, Gamelli RL, Gibran NS, Altstein L, McDonald-Smith GP, Tompkins RG, Hunt JL,
J Burn Care Res. 2007;28(2):222-30 - PMID: 17351437

The practice of venous thromboembolism prophylaxis in the major trauma patient.

Nathens AB, McMurray MK, Cuschieri J, Durr EA, Moore EE, Bankey PE, Freeman B, Harbrecht BG, Johnson JL, Minei JP, McKinley BA, Moore FA, Shapiro MB, West MA, Tompkins RG, Maier RV
J Trauma. 2007;62(3):557-62; discussion 562-3 - PMID: 17414328

Uncoupling protein 3 expression and intramyocellular lipid accumulation by NMR following local burn trauma.

Zhang Q, Cao H, Astrakas LG, Mintzopoulos D, Mindrinos MN, Schulz J, Tompkins RG, Rahme LG, Tzika AA
Int J Mol Med. 2006;18(6):1223-9 - PMID: 17089030

A microfluidic device for practical label-free CD4(+) T cell counting of HIV-infected subjects.

Cheng X, Irimia D, Dixon M, Sekine K, Demirci U, Zamir L, Tompkins RG, Rodriguez W, Toner M
Lab Chip. 2006;7(2):170-8 - PMID: 17268618 - PMCID: PMC4028372

A bioartificial liver device secreting interleukin-1 receptor antagonist for the treatment of hepatic failure in rats.

Shinoda M, Tilles AW, Kobayashi N, Wakabayashi G, Takayanagi A, Totsugawa T, Harada H, Obara H, Suganuma K, Berthiaume F, Shimazu M, Shimizu N, Tanaka N, Kitajima M, Tompkins RG, Toner M, Yarmush ML
J Surg Res. 2006;137(1):130-40 - PMID: 17081566 - PMCID: PMC3201777

Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways.

Laudanski K, Miller-Graziano C, Xiao W, Mindrinos MN, Richards DR, De A, Moldawer LL, Maier RV, Bankey P, Baker HV, Brownstein BH, Cobb JP, Calvano SE, Davis RW, Tompkins RG
Proc Natl Acad Sci U S A. 2006;103(42):15564-9 - PMID: 17032758 - PMCID: PMC1592643

Local and distant burn injury alter immuno-inflammatory gene expression in skeletal muscle.

Padfield KE, Zhang Q, Gopalan S, Tzika AA, Mindrinos MN, Tompkins RG, Rahme LG
J Trauma. 2006;61(2):280-92 - PMID: 16917440

Microfluidic isolation of leukocytes from whole blood for phenotype and gene expression analysis.

Sethu P, Moldawer LL, Mindrinos MN, Scumpia PO, Tannahill CL, Wilhelmy J, Efron PA, Brownstein BH, Tompkins RG, Toner M
Anal Chem. 2006;78(15):5453-61 - PMID: 16878882

Inflammation and the host response to injury: an overview of the multicenter study of the genomic and proteomic response to burn injury.

Klein MB, Silver G, Gamelli RL, Gibran NS, Herndon DN, Hunt JL, Tompkins RG,
J Burn Care Res. 2006;27(4):448-51 - PMID: 16819346

Panning of multiple subsets of leukocytes on antibody-decorated poly(ethylene) glycol-coated glass slides.

Sekine K, Revzin A, Tompkins RG, Toner M
J Immunol Methods. 2006;313(1-2):96-109 - PMID: 16822521

High dynamic range characterization of the trauma patient plasma proteome.

Liu T, Qian WJ, Gritsenko MA, Xiao W, Moldawer LL, Kaushal A, Monroe ME, Varnum SM, Moore RJ, Purvine SO, Maier RV, Davis RW, Tompkins RG, Camp DG, Smith RD,
Mol Cell Proteomics. 2006;5(10):1899-913 - PMID: 16684767 - PMCID: PMC1783978

Adipocyte apoptosis after burn injury is associated with altered fat metabolism.

Yasuhara S, Kaneki M, Sugita H, Sugita M, Asai A, Sahani N, Chon JY, Tompkins RG, Martyn JA
J Burn Care Res. 2006;27(3):367-76 - PMID: 16679908

Negative chemical ionization gas chromatography/mass spectrometry to quantify urinary 3-methylhistidine: application to burn injury.

Beffa DC, Carter EA, Lu XM, Yu YM, Prelack K, Sheridan RL, Young VR, Fischman AJ, Tompkins RG
Anal Biochem. 2006;355(1):95-101 - PMID: 16762308

Treatment of fulminant hepatic failure in rats using a bioartificial liver device containing porcine hepatocytes producing interleukin-1 receptor antagonist.

Shinoda M, Tilles AW, Wakabayashi G, Takayanagi A, Harada H, Obara H, Suganuma K, Berthiaume F, Shimazu M, Shimizu N, Kitajima M, Tompkins RG, Toner M, Yarmush ML
Tissue Eng. 2006;12(5):1313-23 - PMID: 16771644 - PMCID: PMC3202215

Nonmetabolizable glucose compounds impart cryotolerance to primary rat hepatocytes.

Sugimachi K, Roach KL, Rhoads DB, Tompkins RG, Toner M
Tissue Eng. 2006;12(3):579-88 - PMID: 16579691

Selective activation of peripheral blood T cell subsets by endotoxin infusion in healthy human subjects corresponds to differential chemokine activation.

De AK, Miller-Graziano CL, Calvano SE, Laudanski K, Lowry SF, Moldawer LL, Remick DG, Rajicic N, Schoenfeld D, Tompkins RG
J Immunol. 2005;175(9):6155-62 - PMID: 16237112

Significance analysis of time course microarray experiments.

Storey JD, Xiao W, Leek JT, Tompkins RG, Davis RW
Proc Natl Acad Sci U S A. 2005;102(36):12837-42 - PMID: 16141318 - PMCID: PMC1201697

Site-specific detection of S-nitrosylated PKB alpha/Akt1 from rat soleus muscle using CapLC-Q-TOF(micro) mass spectrometry.

Lu XM, Lu M, Tompkins RG, Fischman AJ
J Mass Spectrom. 2005;40(9):1140-8 - PMID: 16041729

Enrichment using antibody-coated microfluidic chambers in shear flow: model mixtures of human lymphocytes.

Sin A, Murthy SK, Revzin A, Tompkins RG, Toner M
Biotechnol Bioeng. 2005;91(7):816-26 - PMID: 16037988

Proton NMR spectroscopy shows lipids accumulate in skeletal muscle in response to burn trauma-induced apoptosis.

Astrakas LG, Goljer I, Yasuhara S, Padfield KE, Zhang Q, Gopalan S, Mindrinos MN, Dai G, Yu YM, Martyn JA, Tompkins RG, Rahme LG, Tzika AA
FASEB J. 2005;19(11):1431-40 - PMID: 16126910

A network-based analysis of systemic inflammation in humans.

Calvano SE, Xiao W, Richards DR, Felciano RM, Baker HV, Cho RJ, Chen RO, Brownstein BH, Cobb JP, Tschoeke SK, Miller-Graziano C, Moldawer LL, Mindrinos MN, Davis RW, Tompkins RG, Lowry SF,
Nature. 2005;437(7061):1032-7 - PMID: 16136080

Molecular mechanism(s) of burn-induced insulin resistance in murine skeletal muscle: role of IRS phosphorylation.

Zhang Q, Carter EA, Ma BY, White M, Fischman AJ, Tompkins RG
Life Sci. 2005;77(24):3068-77 - PMID: 15982669

A new approach for sequencing human IRS1 phosphotyrosine-containing peptides using CapLC-Q-TOF(micro).

Lu XM, Lu MY, Fischman AJ, Tompkins RG
J Mass Spectrom. 2005;40(5):599-607 - PMID: 15739155

Burn injury causes mitochondrial dysfunction in skeletal muscle.

Padfield KE, Astrakas LG, Zhang Q, Gopalan S, Dai G, Mindrinos MN, Tompkins RG, Rahme LG, Tzika AA
Proc Natl Acad Sci U S A. 2005;102(15):5368-73 - PMID: 15809440 - PMCID: PMC556259

Application of genome-wide expression analysis to human health and disease.

Cobb JP, Mindrinos MN, Miller-Graziano C, Calvano SE, Baker HV, Xiao W, Laudanski K, Brownstein BH, Elson CM, Hayden DL, Herndon DN, Lowry SF, Maier RV, Schoenfeld DA, Moldawer LL, Davis RW, Tompkins RG, Baker HV, Bankey P, Billiar T, Brownstein BH, Calvano SE, Camp D, Chaudry I, Cobb JP, Davis RW, Elson CM, Freeman B, Gamelli R, Gibran N, Harbrecht B, Hayden DL, Heagy W, Heimbach D, Herndon DN, Horton J, Hunt J, Laudanski K, Lederer J, Lowry SF, Maier RV, Mannick J, McKinley B, Miller-Grazi ...
Proc Natl Acad Sci U S A. 2005;102(13):4801-6 - PMID: 15781863 - PMCID: PMC555033

Quantitative proteome analysis of human plasma following in vivo lipopolysaccharide administration using 16O/18O labeling and the accurate mass and time tag approach.

Qian WJ, Monroe ME, Liu T, Jacobs JM, Anderson GA, Shen Y, Moore RJ, Anderson DJ, Zhang R, Calvano SE, Lowry SF, Xiao W, Moldawer LL, Davis RW, Tompkins RG, Camp DG, Smith RD,
Mol Cell Proteomics. 2005;4(5):700-9 - PMID: 15753121 - PMCID: PMC1829297

Evolution of intrahepatic carbon, nitrogen, and energy metabolism in a D-galactosamine-induced rat liver failure model.

Yokoyama T, Banta S, Berthiaume F, Nagrath D, Tompkins RG, Yarmush ML
Metab Eng. 2005;7(2):88-103 - PMID: 15781418

Comparative proteome analyses of human plasma following in vivo lipopolysaccharide administration using multidimensional separations coupled with tandem mass spectrometry.

Qian WJ, Jacobs JM, Camp DG, Monroe ME, Moore RJ, Gritsenko MA, Calvano SE, Lowry SF, Xiao W, Moldawer LL, Davis RW, Tompkins RG, Smith RD
Proteomics. 2005;5(2):572-84 - PMID: 15627965 - PMCID: PMC1781926

Cryopreservation of isolated primary rat hepatocytes: enhanced survival and long-term hepatospecific function.

Sosef MN, Baust JM, Sugimachi K, Fowler A, Tompkins RG, Toner M
Ann Surg. 2005;241(1):125-33 - PMID: 15622000 - PMCID: PMC1356855

Effect of flow and surface conditions on human lymphocyte isolation using microfluidic chambers.

Murthy SK, Sin A, Tompkins RG, Toner M
Langmuir. 2004;20(26):11649-55 - PMID: 15595794

Continuous flow microfluidic device for rapid erythrocyte lysis.

Sethu P, Anahtar M, Moldawer LL, Tompkins RG, Toner M
Anal Chem. 2004;76(21):6247-53 - PMID: 15516115

Whole blood and leukocyte RNA isolation for gene expression analyses.

Feezor RJ, Baker HV, Mindrinos M, Hayden D, Tannahill CL, Brownstein BH, Fay A, MacMillan S, Laramie J, Xiao W, Moldawer LL, Cobb JP, Laudanski K, Miller-Graziano CL, Maier RV, Schoenfeld D, Davis RW, Tompkins RG,
Physiol Genomics. 2004;19(3):247-54 - PMID: 15548831

Development of a microfabricated cytometry platform for characterization and sorting of individual leukocytes.

Revzin A, Sekine K, Sin A, Tompkins RG, Toner M
Lab Chip. 2004;5(1):30-7 - PMID: 15616737

Single-cell chemical lysis in picoliter-scale closed volumes using a microfabricated device.

Irimia D, Tompkins RG, Toner M
Anal Chem. 2004;76(20):6137-43 - PMID: 15481964

Insulin resistance in thermally-injured rats is associated with post-receptor alterations in skeletal muscle, liver and adipose tissue.

Carter EA, Burks D, Fischman AJ, White M, Tompkins RG
Int J Mol Med. 2004;14(4):653-8 - PMID: 15375597

Support of the metabolic response to burn injury.

Herndon DN, Tompkins RG
Lancet. 2004;363(9424):1895-902 - PMID: 15183630

Short-term enteral glutamine does not enhance protein accretion in burned children: a stable isotope study.

Sheridan RL, Prelack K, Yu YM, Lydon M, Petras L, Young VR, Tompkins RG
Surgery. 2004;135(6):671-8 - PMID: 15179374

Long-term function of cryopreserved rat hepatocytes in a coculture system.

Sugimachi K, Sosef MN, Baust JM, Fowler A, Tompkins RG, Toner M
Cell Transplant. 2004;13(2):187-95 - PMID: 15129765

Ultra-high-efficiency strong cation exchange LC/RPLC/MS/MS for high dynamic range characterization of the human plasma proteome.

Shen Y, Jacobs JM, Camp DG, Fang R, Moore RJ, Smith RD, Xiao W, Davis RW, Tompkins RG
Anal Chem. 2004;76(4):1134-44 - PMID: 14961748

What's new in burns and metabolism.

Sheridan RL, Tompkins RG
J Am Coll Surg. 2004;198(2):243-63 - PMID: 14759783

Technique for expanding the donor liver pool: heat shock preconditioning in a rat fatty liver model.

Mokuno Y, Berthiaume F, Tompkins RG, Balis UJ, Yarmush ML
Liver Transpl. 2004;10(2):264-72 - PMID: 14762865

Analysis of Pseudomonas aeruginosa 4-hydroxy-2-alkylquinolines (HAQs) reveals a role for 4-hydroxy-2-heptylquinoline in cell-to-cell communication.

Déziel E, Lépine F, Milot S, He J, Mindrinos MN, Tompkins RG, Rahme LG
Proc Natl Acad Sci U S A. 2004;101(5):1339-44 - PMID: 14739337 - PMCID: PMC337054

Metabolic fate of extrahepatic arginine in liver after burn injury.

Chen CL, Fei Z, Carter EA, Lu XM, Hu RH, Young VR, Tompkins RG, Yu YM
Metabolism. 2003;52(10):1232-9 - PMID: 14564672

Central role of interleukin-6 in burn induced stimulation of hepatic amino acid transport.

Pawlik TM, Carter EA, Bode BP, Fischman AJ, Tompkins RG
Int J Mol Med. 2003;12(4):541-8 - PMID: 12964032

The Drosophila melanogaster toll pathway participates in resistance to infection by the gram-negative human pathogen Pseudomonas aeruginosa.

Lau GW, Goumnerov BC, Walendziewicz CL, Hewitson J, Xiao W, Mahajan-Miklos S, Tompkins RG, Perkins LA, Rahme LG
Infect Immun. 2003;71(7):4059-66 - PMID: 12819096 - PMCID: PMC162001

Efficacy of an extracorporeal flat-plate bioartificial liver in treating fulminant hepatic failure.

Shito M, Tilles AW, Tompkins RG, Yarmush ML, Toner M
J Surg Res. 2003;111(1):53-62 - PMID: 12842448

Bioengineering of liver assist devices.

Tilles AW, Berthiaume F, Yarmush ML, Tompkins RG, Toner M
J Hepatobiliary Pancreat Surg. 2003;9(6):686-96 - PMID: 12658402

In vivo rabbit hindquarter model for assessment of regional burn hypermetabolism.

Xu J, Fei Z, Yu YM, Xu W, Rhodes A, Tompkins RG, Schulz JT
J Appl Physiol. 2002;94(1):135-40 - PMID: 12391055

Use of Integra artificial skin is associated with decreased length of stay for severely injured adult burn survivors.

Ryan CM, Schoenfeld DA, Malloy M, Schulz JT, Sheridan RL, Tompkins RG
J Burn Care Rehabil. 2002;23(5):311-7 - PMID: 12352131

Effectiveness of bacteria-controlled nursing units in preventing cross-colonization with resistant bacteria in severely burned children.

Weber JM, Sheridan RL, Schulz JT, Tompkins RG, Ryan CM
Infect Control Hosp Epidemiol. 2002;23(9):549-51 - PMID: 12269456

Regional measurement of canine skeletal muscle blood flow by positron emission tomography with H2(15)O.

Fischman AJ, Hsu H, Carter EA, Yu YM, Tompkins RG, Guerrero JL, Young VR, Alpert NM
J Appl Physiol. 2002;92(4):1709-16 - PMID: 11896041

Mapping of local renal blood flow with PET and H(2)(15)O.

Alpert NM, Rabito CA, Correia DJ, Babich JW, Littman BH, Tompkins RG, Rubin NT, Rubin RH, Fischman AJ
J Nucl Med. 2002;43(4):470-5 - PMID: 11937589

Inducible nitric oxide synthase plays a role in LPS-induced hyperglycemia and insulin resistance.

Sugita H, Kaneki M, Tokunaga E, Sugita M, Koike C, Yasuhara S, Tompkins RG, Martyn JA
Am J Physiol Endocrinol Metab. 2002;282(2):E386-94 - PMID: 11788371

Plasma L-5-oxoproline kinetics and whole blood glutathione synthesis rates in severely burned adult humans.

Yu YM, Ryan CM, Fei ZW, Lu XM, Castillo L, Schultz JT, Tompkins RG, Young VR
Am J Physiol Endocrinol Metab. 2002;282(2):E247-58 - PMID: 11788355

Long-term consequences of toxic epidermal necrolysis in children.

Sheridan RL, Schulz JT, Ryan CM, Schnitzer JJ, Lawlor D, Driscoll DN, Donelan MB, Tompkins RG
Pediatrics. 2002;109(1):74-8 - PMID: 11773544

Long-term maintenance of cytochrome P450 activities by rat hepatocyte/3T3 cell co-cultures in heparinized human plasma.

Washizu J, Berthiaume F, Mokuno Y, Tompkins RG, Toner M, Yarmush ML
Tissue Eng. 2001;7(6):691-703 - PMID: 11749727

The American Burn Association in the New Millennium.

Tompkins RG
J Burn Care Rehabil. 2001;22(6):369-374 - PMID: 11773770

Antibiotic prophylaxis for group A streptococcal burn wound infection is not necessary.

Sheridan RL, Weber JM, Pasternack MS, Tompkins RG
J Trauma. 2001;51(2):352-5 - PMID: 11493799

Intrahepatic amino acid and glucose metabolism in a D-galactosamine-induced rat liver failure model.

Arai K, Lee K, Berthiaume F, Tompkins RG, Yarmush ML
Hepatology. 2001;34(2):360-71 - PMID: 11481621

A fulminant hepatic failure model in the rat: involvement of interleukin-1beta and tumor necrosis factor-alpha.

Shito M, Balis UJ, Tompkins RG, Yarmush ML, Toner M
Dig Dis Sci. 2001;46(8):1700-8 - PMID: 11508670

Initial experience with a composite autologous skin substitute.

Sheridan RL, Morgan JR, Cusick JL, Petras LM, Lydon MM, Tompkins RG
Burns. 2001;27(5):421-4 - PMID: 11451592

Young age is not a predictor of mortality in burns.

Sheridan RL, Weber JM, Schnitzer JJ, Schulz JT, Ryan CM, Tompkins RG
Pediatr Crit Care Med. 2001;2(3):223-224 - PMID: 12793945

In vitro and in vivo evaluation of albumin synthesis rate of porcine hepatocytes in a flat-plate bioreactor.

Shito M, Kim NH, Baskaran H, Tilles AW, Tompkins RG, Yarmush ML, Toner M
Artif Organs. 2001;25(7):571-8 - PMID: 11493279

Arginine and ornithine kinetics in severely burned patients: increased rate of arginine disposal.

Yu YM, Ryan CM, Castillo L, Lu XM, Beaumier L, Tompkins RG, Young VR
Am J Physiol Endocrinol Metab. 2001;280(3):E509-17 - PMID: 11171607

Cutaneous herpetic infections complicating burns.

Sheridan RL, Schulz JT, Weber JM, Ryan CM, Pasternack MS, Tompkins RG
Burns. 2000;26(7):621-4 - PMID: 10925184

A 10-year experience with toxic epidermal necrolysis.

Schulz JT, Sheridan RL, Ryan CM, MacKool B, Tompkins RG
J Burn Care Rehabil. 2000;21(3):199-204 - PMID: 10850900

Optimization of rat hepatocyte culture in citrated human plasma.

Washizu J, Berthiaume F, Chan C, Tompkins RG, Toner M, Yarmush ML
J Surg Res. 2000;93(2):237-46 - PMID: 11027466

Amino acid supplementation improves cell-specific functions of the rat hepatocytes exposed to human plasma.

Washizu J, Chan C, Berthiaume F, Tompkins RG, Toner M, Yarmush ML
Tissue Eng. 2000;6(5):497-504 - PMID: 11074936

Plants and animals share functionally common bacterial virulence factors.

Rahme LG, Ausubel FM, Cao H, Drenkard E, Goumnerov BC, Lau GW, Mahajan-Miklos S, Plotnikova J, Tan MW, Tsongalis J, Walendziewicz CL, Tompkins RG
Proc Natl Acad Sci U S A. 2000;97(16):8815-21 - PMID: 10922040 - PMCID: PMC34017

Artificial skin.

Schulz JT, Tompkins RG, Burke JF
Annu Rev Med. 2000;51:231-44 - PMID: 10774462

Blood glutathione synthesis rates in healthy adults receiving a sulfur amino acid-free diet.

Lyons J, Rauh-Pfeiffer A, Yu YM, Lu XM, Zurakowski D, Tompkins RG, Ajami AM, Young VR, Castillo L
Proc Natl Acad Sci U S A. 2000;97(10):5071-6 - PMID: 10792033 - PMCID: PMC25783

Current expectations for survival in pediatric burns.

Sheridan RL, Remensnyder JP, Schnitzer JJ, Schulz JT, Ryan CM, Tompkins RG
Arch Pediatr Adolesc Med. 2000;154(3):245-9 - PMID: 10710021

Management of severe toxic epidermal necrolysis in children.

Sheridan RL, Weber JM, Schulz JT, Ryan CM, Low HM, Tompkins RG
J Burn Care Rehabil. 2000;20(6):497-500 - PMID: 10613688

Long-term outcome of children surviving massive burns.

Sheridan RL, Hinson MI, Liang MH, Nackel AF, Schoenfeld DA, Ryan CM, Mulligan JL, Tompkins RG
JAMA. 2000;283(1):69-73 - PMID: 10632282

Low-dose inhaled nitric oxide in acutely burned children with profound respiratory failure.

Sheridan RL, Zapol WM, Ritz RH, Tompkins RG
Surgery. 1999;126(5):856-62 - PMID: 10568185

Cutaneous burn injury alters relative tricarboxylic acid cycle fluxes in rat liver.

Yarmush DM, MacDonald AD, Foy BD, Berthiaume F, Tompkins RG, Yarmush ML
J Burn Care Rehabil. 1999;20(4):292-302 - PMID: 10425591

Measurement of muscle protein synthesis by positron emission tomography with L-[methyl-11C]methionine: effects of transamination and transmethylation.

Carter EA, Yu YM, Alpert NM, Bonab AA, Tompkins RG, Fischman AJ
J Trauma. 1999;47(2):341-5 - PMID: 10452471

A unique mechanism of desensitization to lipolysis mediated by beta(3)-adrenoceptor in rats with thermal injury.

Ikezu T, Yasuhara S, Granneman JG, Kraemer FB, Okamoto T, Tompkins RG, Martyn JA
Am J Physiol. 1999;277(2 Pt 1):E316-24 - PMID: 10444428

The metabolic basis of the increase of the increase in energy expenditure in severely burned patients.

Yu YM, Tompkins RG, Ryan CM, Young VR
JPEN J Parenter Enteral Nutr. 1999;23(3):160-8 - PMID: 10338224

A 15-year experience with varicella infections in a pediatric burn unit.

Sheridan RL, Weber JM, Pasternak MM, Mulligan JM, Tompkins RG
Burns. 1999;25(4):353-6 - PMID: 10431985

Acute hand burns in children: management and long-term outcome based on a 10-year experience with 698 injured hands.

Sheridan RL, Baryza MJ, Pessina MA, O'Neill KM, Cipullo HM, Donelan MB, Ryan CM, Schulz JT, Schnitzer JJ, Tompkins RG
Ann Surg. 1999;229(4):558-64 - PMID: 10203090 - PMCID: PMC1191743

Pseudomonas aeruginosa killing of Caenorhabditis elegans used to identify P. aeruginosa virulence factors.

Tan MW, Rahme LG, Sternberg JA, Tompkins RG, Ausubel FM
Proc Natl Acad Sci U S A. 1999;96(5):2408-13 - PMID: 10051655 - PMCID: PMC26797

Skin substitutes in burns.

Sheridan RL, Tompkins RG
Burns. 1999;25(2):97-103 - PMID: 10208382

Laser ablation of burns: initial clinical trial.

Sheridan RL, Lydon MM, Petras LM, Schomacker KT, Tompkins RG, Glatter RD, Parrish JA
Surgery. 1999;125(1):92-5 - PMID: 9889803

Characterization of a composite tissue model that supports clonal growth of human melanocytes in vitro and in vivo.

Medalie DA, Tompkins RG, Morgan JR
J Invest Dermatol. 1998;111(5):810-6 - PMID: 9804343

Muscle protein synthesis by positron-emission tomography with L-[methyl-11C]methionine in adult humans.

Fischman AJ, Yu YM, Livni E, Babich JW, Young VR, Alpert NM, Tompkins RG
Proc Natl Acad Sci U S A. 1998;95(22):12793-8 - PMID: 9788993 - PMCID: PMC23595

Maximal parenteral glucose oxidation in hypermetabolic young children: a stable isotope study.

Sheridan RL, Yu YM, Prelack K, Young VR, Burke JF, Tompkins RG
JPEN J Parenter Enteral Nutr. 1998;22(4):212-6 - PMID: 9661121

Both C3a and C3a(desArg) regulate interleukin-6 synthesis in human peripheral blood mononuclear cells.

Takabayashi T, Vannier E, Burke JF, Tompkins RG, Gelfand JA, Clark BD
J Infect Dis. 1998;177(6):1622-8 - PMID: 9607842

Death in the burn unit: sterile multiple organ failure.

Sheridan RL, Ryan CM, Yin LM, Hurley J, Tompkins RG
Burns. 1998;24(4):307-11 - PMID: 9688194

A rabbit model for metabolic studies after burn injury.

Hu RH, Yu YM, Costa D, Young VR, Ryan CM, Burke JF, Tompkins RG
J Surg Res. 1998;75(2):153-60 - PMID: 9655088

Genetically modified human keratinocytes overexpressing PDGF-A enhance the performance of a composite skin graft.

Eming SA, Medalie DA, Tompkins RG, Yarmush ML, Morgan JR
Hum Gene Ther. 1998;9(4):529-39 - PMID: 9525314

Objective estimates of the probability of death from burn injuries.

Ryan CM, Schoenfeld DA, Thorpe WP, Sheridan RL, Cassem EH, Tompkins RG
N Engl J Med. 1998;338(6):362-6 - PMID: 9449729

Ice formation in isolated human hepatocytes and human liver tissue.

Bischof JC, Ryan CM, Tompkins RG, Yarmush ML, Toner M
ASAIO J. 1997;43(4):271-8 - PMID: 9242939

Use of model plant hosts to identify Pseudomonas aeruginosa virulence factors.

Rahme LG, Tan MW, Le L, Wong SM, Tompkins RG, Calderwood SB, Ausubel FM
Proc Natl Acad Sci U S A. 1997;94(24):13245-50 - PMID: 9371831 - PMCID: PMC24294

Analysis of thermal injury-induced insulin resistance in rodents. Implication of postreceptor mechanisms.

Ikezu T, Okamoto T, Yonezawa K, Tompkins RG, Martyn JA
J Biol Chem. 1997;272(40):25289-95 - PMID: 9312146

Burns in children younger than two years of age: an experience with 200 consecutive admissions.

Sheridan RL, Ryan CM, Petras LM, Lydon MK, Weber JM, Tompkins RG
Pediatrics. 1997;100(4):721-3 - PMID: 9310533

Control of hypertrophic scar growth using selective photothermolysis.

Reiken SR, Wolfort SF, Berthiaume F, Compton C, Tompkins RG, Yarmush ML
Lasers Surg Med. 1997;21(1):7-12 - PMID: 9228634

Localization of radiolabeled chemotactic peptide at focal sites of Escherichia coli infection in rabbits: evidence for a receptor-specific mechanism.

Babich JW, Tompkins RG, Graham W, Barrow SA, Fischman AJ
J Nucl Med. 1997;38(8):1316-22 - PMID: 9255175

Differences in dermal analogs influence subsequent pigmentation, epidermal differentiation, basement membrane, and rete ridge formation of transplanted composite skin grafts.

Medalie DA, Eming SA, Collins ME, Tompkins RG, Yarmush ML, Morgan JR
Transplantation. 1997;64(3):454-65 - PMID: 9275113

Metabolic alterations in muscle of thermally injured rabbits, measured by positron emission tomography.

Carter EA, Tompkins RG, Hsu H, Christian B, Alpert NM, Weise S, Fischman AJ
Life Sci. 1997;61(1):39-44 - PMID: 9200667

Energy and protein provisions for thermally injured children revisited: an outcome-based approach for determining requirements.

Prelack K, Cunningham JJ, Sheridan RL, Tompkins RG
J Burn Care Rehabil. 1997;18(2):177-81; discussion 176 - PMID: 9095430

Nosocomial infections in pediatric patients with burns.

Weber JM, Sheridan RL, Pasternack MS, Tompkins RG
Am J Infect Control. 1997;25(3):195-201 - PMID: 9202814

TCA cycle flux estimates from NMR- and GC-MS-determined [13C]glutamate isotopomers in liver.

Vogt JA, Yarmush DM, Yu YM, Zupke C, Fischman AJ, Tompkins RG, Burke JF
Am J Physiol. 1997;272(6 Pt 1):C2049-62 - PMID: 9227434

Urinary urea nitrogen is imprecise as a predictor of protein balance in burned children.

Prelack K, Dwyer J, Yu YM, Sheridan RL, Tompkins RG
J Am Diet Assoc. 1997;97(5):489-95 - PMID: 9145086

Inhaled nitric oxide in burn patients with respiratory failure.

Sheridan RL, Hurford WE, Kacmarek RM, Ritz RH, Yin LM, Ryan CM, Tompkins RG
J Trauma. 1997;42(4):629-34 - PMID: 9137249

Evaluation of acellular human dermis as a dermal analog in a composite skin graft.

Medalie DA, Tompkins RG, Morgan JR
ASAIO J. 1997;42(5):M455-62 - PMID: 8944923

Effect of burn injury on glucose and nitrogen metabolism in the liver: preliminary studies in a perfused liver system.

Yamaguchi Y, Yu YM, Zupke C, Yarmush DM, Berthiaume F, Tompkins RG, Yarmush ML
Surgery. 1997;121(3):295-303 - PMID: 9092130

The role of proinflammatory cytokines in inflammatory and metabolic responses.

Tompkins RG
Ann Surg. 1997;225(3):243-5 - PMID: 9060578 - PMCID: PMC1190672

Interaction with autologous platelets multiplies interleukin-1 and tumor necrosis factor production in mononuclear cells.

Aiura K, Clark BD, Dinarello CA, Margolis NH, Kaplanski G, Burke JF, Tompkins RG, Gelfand JA
J Infect Dis. 1997;175(1):123-9 - PMID: 8985205

Quantitative aspects of interorgan relationships among arginine and citrulline metabolism.

Yu YM, Burke JF, Tompkins RG, Martin R, Young VR
Am J Physiol. 1996;271(6 Pt 1):E1098-109 - PMID: 8997231

Extracorporeal plasma perfusion of cultured hepatocytes: effect of intermittent perfusion on hepatocyte function and morphology.

Stefanovich P, Matthew HW, Toner M, Tompkins RG, Yarmush ML
J Surg Res. 1996;66(1):57-63 - PMID: 8954832

Thermal injury in rats alters glucose utilization by skin, wound, and small intestine, but not by skeletal muscle.

Carter EA, Tompkins RG, Babich JW, Correia J, Bailey EM, Fischman AJ
Metabolism. 1996;45(9):1161-7 - PMID: 8781305

Effects of plasma exposure on cultured hepatocytes: Implications for bioartificial liver support.

Matthew HW, Sternberg J, Stefanovich P, Morgan JR, Toner M, Tompkins RG, Yarmush ML
Biotechnol Bioeng. 1996;51(1):100-11 - PMID: 18627093

Kinetics of plasma arginine and leucine in pediatric burn patients.

Yu YM, Sheridan RL, Burke JF, Chapman TE, Tompkins RG, Young VR
Am J Clin Nutr. 1996;64(1):60-6 - PMID: 8669415

Evaluation of human skin reconstituted from composite grafts of cultured keratinocytes and human acellular dermis transplanted to athymic mice.

Medalie DA, Eming SA, Tompkins RG, Yarmush ML, Krueger GG, Morgan JR
J Invest Dermatol. 1996;107(1):121-7 - PMID: 8752850

Decreased cerebral glucose utilization in rats during the ebb phase of thermal injury.

Carter EA, Tompkins RG, Babich JW, Correia JA, Fischman AJ
J Trauma. 1996;40(6):930-5 - PMID: 8656479

Control of hypertrophic scar growth using antibody-targeted photolysis.

Wolfort SF, Reiken SR, Berthiaume F, Tompkins RG, Yarmush ML
J Surg Res. 1996;62(1):17-22 - PMID: 8606503

Burn depth estimation by use of indocyanine green fluorescence: initial human trial.

Sheridan RL, Schomaker KT, Lucchina LC, Hurley J, Yin LM, Tompkins RG, Jerath M, Torri A, Greaves KW, Bua DP
J Burn Care Rehabil. 1996;16(6):602-4 - PMID: 8582937

Planimetry study of the percent of body surface represented by the hand and palm: sizing irregular burns is more accurately done with the palm.

Sheridan RL, Petras L, Basha G, Salvo P, Cifrino C, Hinson M, McCabe M, Fallon J, Tompkins RG
J Burn Care Rehabil. 1996;16(6):605-6 - PMID: 8582938

Effective postoperative protection for grafted posterior surfaces: the quilted dressing.

Sheridan RL, Behringer GE, Ryan CM, Bondoc CC, Quinby WC, Tompkins RG, Burke JF
J Burn Care Rehabil. 1996;16(6):607-9 - PMID: 8582939

Candidemia in the pediatric patient with burns.

Sheridan RL, Weber JM, Budkevich LG, Tompkins RG
J Burn Care Rehabil. 1996;16(4):440-3 - PMID: 8582925

Accelerated healing and reduced need for grafting in pediatric patients with burns treated with arginine-glycine-aspartic acid peptide matrix. RGD Study Group.

Hansbrough JF, Herndon DN, Heimbach DM, Solem LD, Gamelli RL, Tompkins RG
J Burn Care Rehabil. 1996;16(4):377-87 - PMID: 8582916

Measurement of muscle protein synthesis by positron emission tomography with L-[methyl-11C]methionine.

Hsu H, Yu YM, Babich JW, Burke JF, Livni E, Tompkins RG, Young VR, Alpert NM, Fischman AJ
Proc Natl Acad Sci U S A. 1996;93(5):1841-6 - PMID: 8700846 - PMCID: PMC39869

Comparative evaluation of the quantitative utilization of parenterally and enterally administered leucine and L-[1-13C,15N]leucine within the whole body and the splanchnic region.

Yu YM, Young VR, Tompkins RG, Burke JF
JPEN J Parenter Enteral Nutr. 1996;19(3):209-15 - PMID: 8551649

Culture matrix configuration and composition in the maintenance of hepatocyte polarity and function.

Moghe PV, Berthiaume F, Ezzell RM, Toner M, Tompkins RG, Yarmush ML
Biomaterials. 1996;17(3):373-85 - PMID: 8745335

Management strategy in purpura fulminans with multiple organ failure in children.

Sheridan RL, Briggs SE, Remensnyder JP, Tompkins RG
Burns. 1996;22(1):53-6 - PMID: 8719318

Recent clinical experience with cultured autologous epithelium.

Sheridan RL, Tompkins RG
Br J Plast Surg. 1996;49(1):72-4 - PMID: 8705108

Genetically modified human epidermis overexpressing PDGF-A directs the development of a cellular and vascular connective tissue stroma when transplanted to athymic mice--implications for the use of genetically modified keratinocytes to modulate dermal regeneration.

Eming SA, Lee J, Snow RG, Tompkins RG, Yarmush ML, Morgan JR
J Invest Dermatol. 1995;105(6):756-63 - PMID: 7490468

Retrovirus infection: effect of time and target cell number.

Morgan JR, LeDoux JM, Snow RG, Tompkins RG, Yarmush ML
J Virol. 1995;69(11):6994-7000 - PMID: 7474118 - PMCID: PMC189618

Effects of malignancy and interleukin-2 infusion on gut macromolecular permeability.

Ryan CM, Atkins MB, Mier JW, Gelfand JA, Tompkins RG
Crit Care Med. 1995;23(11):1801-6 - PMID: 7587254

Relations among arginine, citrulline, ornithine, and leucine kinetics in adult burn patients.

Yu YM, Ryan CM, Burke JF, Tompkins RG, Young VR
Am J Clin Nutr. 1995;62(5):960-8 - PMID: 7572742

Permissive hypercapnia as a ventilatory strategy in burned children: effect on barotrauma, pneumonia, and mortality.

Sheridan RL, Kacmarek RM, McEttrick MM, Weber JM, Ryan CM, Doody DP, Ryan DP, Schnitzer JJ, Tompkins RG
J Trauma. 1995;39(5):854-9 - PMID: 7474000

Effects of hypothermia on the function, membrane integrity, and cytoskeletal structure of hepatocytes.

Stefanovich P, Ezzell RM, Sheehan SJ, Tompkins RG, Yarmush ML, Toner M
Cryobiology. 1995;32(4):389-403 - PMID: 7656572

Postburn pancreatitis.

Ryan CM, Sheridan RL, Schoenfeld DA, Warshaw AL, Tompkins RG
Ann Surg. 1995;222(2):163-70 - PMID: 7543741 - PMCID: PMC1234774

Clinical experience with the use of biodegradable tacks in pediatric patients with burns.

Sheridan RL, Petras L, Basha G, Tompkins RG
J Burn Care Rehabil. 1995;16(2 Pt 1):143-4 - PMID: 7775509

Common virulence factors for bacterial pathogenicity in plants and animals.

Rahme LG, Stevens EJ, Wolfort SF, Shao J, Tompkins RG, Ausubel FM
Science. 1995;268(5219):1899-902 - PMID: 7604262

Dynamics of cell membrane permeability changes at supraphysiological temperatures.

Bischof JC, Padanilam J, Holmes WH, Ezzell RM, Lee RC, Tompkins RG, Yarmush ML, Toner M
Biophys J. 1995;68(6):2608-14 - PMID: 7647264 - PMCID: PMC1282171

The burn unit as a resource for the management of acute nonburn conditions in children.

Sheridan RL, Briggs SE, Remensnyder JP, Gagnon SW, Doody DP, Ryan DP, Tompkins RG
J Burn Care Rehabil. 1995;16(1):62-4 - PMID: 7721912

Solid organ procurement from burn patients.

Sheridan RL, Stewart B, Tompkins RG
J Trauma. 1995;38(5):824-5 - PMID: 7760420

Dynamics of photoinduced cell plasma membrane injury.

Thorpe WP, Toner M, Ezzell RM, Tompkins RG, Yarmush ML
Biophys J. 1995;68(5):2198-206 - PMID: 7612864 - PMCID: PMC1282125

Plasma arginine and leucine kinetics and urea production rates in burn patients.

Yu YM, Young VR, Castillo L, Chapman TE, Tompkins RG, Ryan CM, Burke JF
Metabolism. 1995;44(5):659-66 - PMID: 7752916

A device to measure the oxygen uptake rate of attached cells: importance in bioartificial organ design.

Foy BD, Rotem A, Toner M, Tompkins RG, Yarmush ML
Cell Transplant. 1995;3(6):515-27 - PMID: 7881763

The activity of cytochrome P450IA1 in stable cultured rat hepatocytes.

Rotem A, Matthew HW, Hsiao PH, Toner M, Tompkins RG, Yarmush ML
Toxicol In Vitro. 1995;9(2):139-49 - PMID: 20650073

Midazolam infusion in pediatric patients with burns who are undergoing mechanical ventilation.

Sheridan RL, McEttrick M, Bacha G, Stoddard F, Tompkins RG
J Burn Care Rehabil. 1995;15(6):515-8 - PMID: 7852455

The acutely burned hand: management and outcome based on a ten-year experience with 1047 acute hand burns.

Sheridan RL, Hurley J, Smith MA, Ryan CM, Bondoc CC, Quinby WC, Tompkins RG, Burke JF
J Trauma. 1995;38(3):406-11 - PMID: 7897728

Central venous catheter sepsis with weekly catheter change in paediatric burn patients: an analysis of 221 catheters.

Sheridan RL, Weber JM, Peterson HF, Tompkins RG
Burns. 1995;21(2):127-9 - PMID: 7766321

Emergency management of major hydrofluoric acid exposures.

Sheridan RL, Ryan CM, Quinby WC, Blair J, Tompkins RG, Burke JF
Burns. 1995;21(1):62-4 - PMID: 7718123

Percutaneous cholecystostomy in the critically ill burn patient.

Sheridan RL, Ryan CM, Lee MJ, Mueller PR, Tompkins RG
J Trauma. 1995;38(2):248-51 - PMID: 7869446

Detection of acute bacterial infection within soft tissue injuries using a 99mTc-labeled chemotactic peptide.

Fischman AJ, Babich JW, Barrow SA, Graham W, Carter E, Tompkins RG, Rubin RH
J Trauma. 1995;38(2):223-7 - PMID: 7869440

Modified Stryker frame for intraoperative positioning of the patient with burns.

Sheridan RL, Hurley J, Lynch L, Balmer J, Ryan CM, Bondoc CC, Quinby WC, Tompkins RG, Burke JF
J Burn Care Rehabil. 1995;15(5):438-40 - PMID: 7995819

Cultured autologous epithelium in patients with burns of ninety percent or more of the body surface.

Sheridan RL, Tompkins RG
J Trauma. 1995;38(1):48-50 - PMID: 7745657

Strategies for success in academic surgery.

Souba WW, Gamelli RL, Lorber MI, Thompson JS, Kron IL, Tompkins RG, Hoyt DB
Surgery. 1995;117(1):90-5 - PMID: 7809842

Intraoperative reflectance oximetry in burn patients.

Sheridan RL, Prelack KM, Petras LM, Szyfelbein SK, Tompkins RG
J Clin Monit. 1995;11(1):32-4 - PMID: 7745451

Staphylococcal toxic shock syndrome in a paediatric burn unit.

Bacha EA, Sheridan RL, Donohue GA, Tompkins RG
Burns. 1994;20(6):499-502 - PMID: 7880413

Control of methicillin-resistant Staphylococcus aureus in a pediatric burn unit.

Sheridan RL, Weber J, Benjamin J, Pasternack MS, Tompkins RG
Am J Infect Control. 1994;22(6):340-5 - PMID: 7695112

Selective adhesion of hepatocytes on patterned surfaces.

Bhatia SN, Toner M, Tompkins RG, Yarmush ML
Ann N Y Acad Sci. 1994;745:187-209 - PMID: 7832508

Nitric oxide production is intensely and persistently increased in tissue by thermal injury.

Carter EA, Derojas-Walker T, Tamir S, Tannenbaum SR, Yu YM, Tompkins RG
Biochem J. 1994;304 ( Pt 1):201-4 - PMID: 7528006 - PMCID: PMC1137472

Femoral arterial catheterization in paediatric burn patients.

Sheridan RL, Weber JM, Tompkins RG
Burns. 1994;20(5):451-2 - PMID: 7999277

The use of pentafluorophenyl derivatives for the 18F labelling of proteins.

Herman LW, Fischman AJ, Tompkins RG, Hanson RN, Byon C, Strauss HW, Elmaleh DR
Nucl Med Biol. 1994;21(7):1005-10 - PMID: 9234356

Rapid quantitation of recombinant retroviruses.

Morgan JR, Lee J, Tompkins RG, Yarmush ML
Biotechnol Prog. 1994;10(4):441-6 - PMID: 7765097

A quantitative model of invasive Pseudomonas infection in burn injury.

Stevens EJ, Ryan CM, Friedberg JS, Barnhill RL, Yarmush ML, Tompkins RG
J Burn Care Rehabil. 1994;15(3):232-5 - PMID: 8056812

Arterial blood pressure immediately after thermal injury: the role of anesthesia.

Trop M, Carter EA, Schiffrin EJ, Tompkins RG
J Burn Care Rehabil. 1994;15(3):224-31 - PMID: 8056811

Antibody-targeted photolysis of bacteria in vivo.

Berthiaume F, Reiken SR, Toner M, Tompkins RG, Yarmush ML
Biotechnology (N Y). 1994;12(7):703-6 - PMID: 7764916

Injury-induced inhibition of fat absorption.

Carter EA, Tompkins RG
J Burn Care Rehabil. 1994;15(2):154-7 - PMID: 8195256

A general model for analysis of the tricarboxylic acid cycle with use of [13C]glutamate isotopomer measurements.

Vogt JA, Fischman AJ, Kempf M, Yu YM, Tompkins RG, Burke JF
Am J Physiol. 1994;266(6 Pt 1):E1012-22 - PMID: 7912892

Prognostic significance of prehospital cardiac or pulmonary resuscitation in paediatric burns patients.

Sheridan RL, Tompkins RG
Burns. 1994;20(3):265-6 - PMID: 8054145

Long-term functional recovery of hepatocytes after cryopreservation in a three-dimensional culture configuration.

Borel Rinkes IH, Toner M, Sheeha SJ, Tompkins RG, Yarmush ML
Cell Transplant. 1994;1(4):281-92 - PMID: 1344301

Assessment of artificial liver support technology.

Yarmush ML, Dunn JC, Tompkins RG
Cell Transplant. 1994;1(5):323-41 - PMID: 1344305

Effectiveness of poloxamer 188 in arresting calcein leakage from thermally damaged isolated skeletal muscle cells.

Padanilam JT, Bischof JC, Lee RC, Cravalho EG, Tompkins RG, Yarmush ML, Toner M
Ann N Y Acad Sci. 1994;720:111-23 - PMID: 7516633

An extracorporeal microscopy perfusion chamber for on-line studies of environmental effects on cultured hepatocytes.

Borel Rinkes IH, Toner M, Tompkins RG, Yarmush ML
J Biomech Eng. 1994;116(2):135-9 - PMID: 8078319

Synthesis of 2-[18F]fluoro-2-deoxy-L-glucose and positron emission tomography studies in monkeys.

Meng J, Elmaleh DR, Jyawook S, Weiss S, Alpert NM, Babich JW, Tompkins RG, Fischman AJ
Nucl Med Biol. 1994;21(4):633-40 - PMID: 9234321

Thermal injury induces very early production of interleukin-1 alpha in the rat by mechanisms other than endotoxemia.

Mester M, Carter EA, Tompkins RG, Gelfand JA, Dinarello CA, Burke JF, Clark BD
Surgery. 1994;115(5):588-96 - PMID: 8178258

Prophylactic antibiotics and their role in the prevention of surgical wound infection.

Sheridan RL, Tompkins RG, Burke JF
Adv Surg. 1994;27:43-65 - PMID: 8140979

Engineering organ perfusion protocols: NMR analysis of hepatocyte isolation from perfused rat liver.

Foy BD, Toner M, Tompkins RG, Yarmush ML
Biotechnol Bioeng. 1994;43(7):661-72 - PMID: 18615766

Oxygen is a factor determining in vitro tissue assembly: Effects on attachment and spreading of hepatocytes.

Rotem A, Toner M, Bhatia S, Foy BD, Tompkins RG, Yarmush ML
Biotechnol Bioeng. 1994;43(7):654-60 - PMID: 18615765

Intracompartmental sepsis in burn patients.

Sheridan RL, Tompkins RG, McManus WF, Pruitt BA
J Trauma. 1994;36(3):301-5 - PMID: 8145308

Additive effects of thermal injury and infection on gut permeability.

Ryan CM, Bailey SH, Carter EA, Schoenfeld DA, Tompkins RG
Arch Surg. 1994;129(3):325-8 - PMID: 8129610

Transport of fluorescent dextrans across the rat ileum after cutaneous thermal injury.

Berthiaume F, Ezzell RM, Toner M, Yarmush ML, Tompkins RG
Crit Care Med. 1994;22(3):455-64 - PMID: 7510222

Antisense DNA delivery in vivo: liver targeting by receptor-mediated uptake.

Lu XM, Fischman AJ, Jyawook SL, Hendricks K, Tompkins RG, Yarmush ML
J Nucl Med. 1994;35(2):269-75 - PMID: 8294998

Antibody Targeted Photolysis.

Yarmush ML, Thorpe WP, Strong L, Rakestraw SL, Toner M, Tompkins RG
Crit Rev Ther Drug Carrier Syst. 1994;10(3):197-252 - PMID: 8258158

Cellular distribution of endotoxin after injection of chemically purified lipopolysaccharide differs from that after injection of live bacteria.

Ge Y, Ezzell RM, Tompkins RG, Warren HS
J Infect Dis. 1994;169(1):95-104 - PMID: 8277203

Management of burn wounds with prompt excision and immediate closure.

Sheridan RL, Tompkins RG, Burke JF
J Intensive Care Med. 1994;9(1):6-17 - PMID: 10146651

Human recombinant interleukin-1 receptor antagonist in the treatment of sepsis syndrome.

Tompkins RG
Crit Care Med. 1994;22(1):3 - PMID: 8124969

An effective technique of scrotal harvest.

Sheridan RL, Ryan CM, Tompkins RG
J Burn Care Rehabil. 1993;14(5):557-8 - PMID: 8245111

Nucleation and growth of ice crystals inside cultured hepatocytes during freezing in the presence of dimethyl sulfoxide.

Karlsson JO, Cravalho EG, Borel Rinkes IH, Tompkins RG, Yarmush ML, Toner M
Biophys J. 1993;65(6):2524-36 - PMID: 8312489 - PMCID: PMC1225995

Absence of change in hepatic lactate metabolism after burn injury.

Carter EA, Khalid MA, Burke JF, Tompkins RG
Burns. 1993;19(6):475-8 - PMID: 8292229

Technetium-99m-labeled chemotactic peptides: comparison with indium-111-labeled white blood cells for localizing acute bacterial infection in the rabbit.

Babich JW, Graham W, Barrow SA, Dragotakes SC, Tompkins RG, Rubin RH, Fischman AJ
J Nucl Med. 1993;34(12):2176-81 - PMID: 8254406

In vivo bioactivity and biodistribution of chemotactic peptide analogs in nonhuman primates.

Fischman AJ, Rauh D, Solomon H, Babich JW, Tompkins RG, Kroon D, Strauss HW, Rubin RH
J Nucl Med. 1993;34(12):2130-4 - PMID: 8254400

Technetium-99m-labeled hydrazino nicotinamide derivatized chemotactic peptide analogs for imaging focal sites of bacterial infection.

Babich JW, Solomon H, Pike MC, Kroon D, Graham W, Abrams MJ, Tompkins RG, Rubin RH, Fischman AJ
J Nucl Med. 1993;34(11):1964-74 - PMID: 8229242

Effect of collagen gel configuration on the cytoskeleton in cultured rat hepatocytes.

Ezzell RM, Toner M, Hendricks K, Dunn JC, Tompkins RG, Yarmush ML
Exp Cell Res. 1993;208(2):442-52 - PMID: 8375473

Thermal injury-induced changes in the rat intestine brush border cytoskeleton.

Ezzell RM, Carter EA, Yarmush ML, Tompkins RG
Surgery. 1993;114(3):591-7 - PMID: 8367816

Optimization of hepatocyte attachment to microcarriers: Importance of oxygen.

Foy BD, Lee J, Morgan J, Toner M, Tompkins RG, Yarmush ML
Biotechnol Bioeng. 1993;42(5):579-88 - PMID: 18613079

Immobilized IL-2 preserves the viability of an IL-2 dependent cell line.

Horwitz JI, Toner M, Tompkins RG, Yarmush ML
Mol Immunol. 1993;30(11):1041-8 - PMID: 8350874

Flavobacterial sepsis in massively burned pediatric patients.

Sheridan RL, Ryan CM, Pasternack MS, Weber JM, Tompkins RG
Clin Infect Dis. 1993;17(2):185-7 - PMID: 8399864

Nonequilibrium freezing of one-cell mouse embryos. Membrane integrity and developmental potential.

Toner M, Cravalho EG, Stachecki J, Fitzgerald T, Tompkins RG, Yarmush ML, Armant DR
Biophys J. 1993;64(6):1908-21 - PMID: 8369414 - PMCID: PMC1262525

Intestinal production of interleukin-1 alpha during endotoxemia in the mouse.

Mester M, Tompkins RG, Gelfand JA, Dinarello CA, Burke JF, Clark BD
J Surg Res. 1993;54(6):584-91 - PMID: 8412068

Proline-mediated enhancement of hepatocyte function in a collagen gel sandwich culture configuration.

Lee J, Morgan JR, Tompkins RG, Yarmush ML
FASEB J. 1993;7(6):586-91 - PMID: 8472895

Burn wound closure using permanent skin replacement materials.

Tompkins RG, Burke JF
World J Surg. 1993;16(1):47-52 - PMID: 1290266

Dynamics of transcriptional and translational processes in hepatocytes cultured in a collagen sandwich.

Dunn JC, Tompkins RG, Yarmush ML
Biotechnol Bioeng. 1993;41(5):593-8 - PMID: 18609591

Gut macromolecular permeability in pancreatitis correlates with severity of disease in rats.

Ryan CM, Schmidt J, Lewandrowski K, Compton CC, Rattner DW, Warshaw AL, Tompkins RG
Gastroenterology. 1993;104(3):890-5 - PMID: 8440440

Acute adrenal insufficiency in the burn intensive care unit.

Sheridan RL, Ryan CM, Tompkins RG
Burns. 1993;19(1):63-6 - PMID: 8435119

Core body temperature responses immediately after cutaneous thermal injury in rats.

Trop M, Tompkins RG, Schiffrin EJ, Carter EA, Burke JF
J Burn Care Rehabil. 1993;13(6):632-8 - PMID: 1469027

Hepatocytes from rat liver perfusions. Physicochemical effects on polyribosome size.

Dunn JC, Friedberg JS, Tompkins RG, Yarmush ML
ASAIO J. 1993;38(4):841-5 - PMID: 1450483

Isolation and long-term culture of human hepatocytes.

Ryan CM, Carter EA, Jenkins RL, Sterling LM, Yarmush ML, Malt RA, Tompkins RG
Surgery. 1993;113(1):48-54 - PMID: 8417488

Dishwasher effluent burns in infants.

Sheridan RL, Sheridan MG, Tompkins RG
Pediatrics. 1993;91(1):142-4 - PMID: 8416479

Oxygen uptake rates in cultured rat hepatocytes.

Rotem A, Toner M, Tompkins RG, Yarmush ML
Biotechnol Bioeng. 1992;40(10):1286-91 - PMID: 18601082

Increased gut permeability early after burns correlates with the extent of burn injury.

Ryan CM, Yarmush ML, Burke JF, Tompkins RG
Crit Care Med. 1992;20(11):1508-12 - PMID: 1424691

Sn-chlorin e6 antibacterial immunoconjugates. An in vitro and in vivo analysis.

Lu XM, Fischman AJ, Stevens E, Lee TT, Strong L, Tompkins RG, Yarmush ML
J Immunol Methods. 1992;156(1):85-99 - PMID: 1431166

Fulminant hepatic failure treated with anti-endotoxin antibody.

Tompkins RG
Crit Care Med. 1992;20(11):1507 - PMID: 1424690

Hepatic tissue engineering. Development of critical technologies.

Yarmush ML, Toner M, Dunn JC, Rotem A, Hubel A, Tompkins RG
Ann N Y Acad Sci. 1992;665:238-52 - PMID: 1416606

Circulating interleukin-1 beta and tumor necrosis factor-alpha concentrations after burn injury in humans.

Cannon JG, Friedberg JS, Gelfand JA, Tompkins RG, Burke JF, Dinarello CA
Crit Care Med. 1992;20(10):1414-9 - PMID: 1395662

A stable long-term hepatocyte culture system for studies of physiologic processes: cytokine stimulation of the acute phase response in rat and human hepatocytes.

Bader A, Borel Rinkes IH, Closs EI, Ryan CM, Toner M, Cunningham JM, Tompkins RG, Yarmush ML
Biotechnol Prog. 1992;8(3):219-25 - PMID: 1368259

Effects of dimethyl sulfoxide on cultured rat hepatocytes in sandwich configuration.

Borel Rinkes IH, Toner M, Ezzell RM, Tompkins RG, Yarmush ML
Cryobiology. 1992;29(4):443-53 - PMID: 1395682

The importance of proline on long-term hepatocyte function in a collagen gel sandwich configuration: regulation of protein secretion.

Lee J, Morgan JR, Tompkins RG, Yarmush ML
Biotechnol Bioeng. 1992;40(2):298-305 - PMID: 18601116

Increased transcellular permeability of rat small intestine after thermal injury.

Carter EA, Gonnella A, Tompkins RG
Burns. 1992;18(2):117-20 - PMID: 1590925

Separation and quantitation of polyethylene glycols 400 and 3350 from human urine by high-performance liquid chromatography.

Ryan CM, Yarmush ML, Tompkins RG
J Pharm Sci. 1992;81(4):350-2 - PMID: 1501072

Antibody-targeted photolysis: in vitro immunological, photophysical, and cytotoxic properties of monoclonal antibody-dextran-Sn(IV) chlorin e6 immunoconjugates.

Rakestraw SL, Ford WE, Tompkins RG, Rodgers MA, Thorpe WP, Yarmush ML
Biotechnol Prog. 1992;8(1):30-9 - PMID: 1371392

Intracellular ice formation during the freezing of hepatocytes cultured in a double collagen gel.

Hubel A, Toner M, Cravalho EG, Yarmush ML, Tompkins RG
Biotechnol Prog. 1992;7(6):554-9 - PMID: 1367755

Hepatocytes in collagen sandwich: evidence for transcriptional and translational regulation.

Dunn JC, Tompkins RG, Yarmush ML
J Cell Biol. 1992;116(4):1043-53 - PMID: 1734019 - PMCID: PMC2289333

A quantitative analysis of tumor specific monoclonal antibody uptake by human melanoma xenografts: effects of antibody immunological properties and tumor antigen expression levels.

Shockley TR, Lin K, Sung C, Nagy JA, Tompkins RG, Dedrick RL, Dvorak HF, Yarmush ML
Cancer Res. 1992;52(2):357-66 - PMID: 1728407

Spatial distribution of tumor-specific monoclonal antibodies in human melanoma xenografts.

Shockley TR, Lin K, Nagy JA, Tompkins RG, Yarmush ML, Dvorak HF
Cancer Res. 1992;52(2):367-76 - PMID: 1728408

LONG-TERM FUNCTIONAL RECOVERY OF HEPATOCYTES AFTER CRYOPRESERVATION IN A THREE-DIMENSIONAL CULTURE CONFIGURATION.

Borel Rinkes IH, Mehmet T, Sheehan SJ, Tompkins RG, Yarmush ML
Cell Transplant. 1992;1(4):281-292 - PMID: 28148377

Long-term in vitro function of adult hepatocytes in a collagen sandwich configuration.

Dunn JC, Tompkins RG, Yarmush ML
Biotechnol Prog. 1991;7(3):237-45 - PMID: 1367596

Cryopreservation of isolated hepatocytes: intracellular ice formation under various chemical and physical conditions.

Harris CL, Toner M, Hubel A, Cravalho EG, Yarmush ML, Tompkins RG
Cryobiology. 1991;28(5):436-44 - PMID: 1752131

Imaging infections with antibodies. A method to localize occult infections.

Tompkins RG, Fischman AJ, Yarmush ML
Chest. 1991;100(3 Suppl):169S-172S - PMID: 1909225

Preparation and characterization of immunoconjugates for antibody-targeted photolysis.

Rakestraw SL, Tompkins RG, Yarmush ML
Bioconjug Chem. 1991;1(3):212-21 - PMID: 1710935

Antibody-targeted photolysis. Bacteriocidal effects of Sn (IV) chlorin e6-dextran-monoclonal antibody conjugates.

Friedberg JS, Tompkins RG, Rakestraw SL, Warren SW, Fischman AJ, Yarmush ML
Ann N Y Acad Sci. 1991;618:383-93 - PMID: 1706578

Penetration of tumor tissue by antibodies and other immunoproteins.

Shockley TR, Lin K, Nagy JA, Tompkins RG, Dvorak HF, Yarmush ML
Ann N Y Acad Sci. 1991;618:367-82 - PMID: 2006796

Quantitative analysis of blood vessel permeability of squirrel monkeys.

Tompkins RG
Am J Physiol. 1991;260(4 Pt 2):H1194-204 - PMID: 2012223

Progress in burn treatment and the use of artificial skin.

Tompkins RG, Burke JF
World J Surg. 1991;14(6):819-24 - PMID: 2256353

Equilibrium binding characteristics of monoclonal antibodies recognizing melanoma cell surface antigens.

Shockley TR, Mandeville JT, Tompkins RG, Yarmush ML
Hybridoma. 1990;9(6):527-44 - PMID: 2076895

A new approach to the cryopreservation of hepatocytes in a sandwich culture configuration.

Koebe HG, Dunn JC, Toner M, Sterling LM, Hubel A, Cravalho EG, Yarmush ML, Tompkins RG
Cryobiology. 1990;27(5):576-84 - PMID: 2249459

Imaging infections with antibodies. A quantitative autoradiographic analysis.

Morrel EM, Tompkins RG, Fischman AJ, Wilkinson RA, Yarmush ML
J Immunol Methods. 1990;130(1):39-48 - PMID: 2193059

Injury-induced inhibition of small intestinal protein and nucleic acid synthesis.

Carter EA, Hatz RA, Yarmush ML, Tompkins RG
Gastroenterology. 1990;98(6):1445-51 - PMID: 1692545

Antibody-targeted photolysis: in vitro studies with Sn(IV) chlorin e6 covalently bound to monoclonal antibodies using a modified dextran carrier.

Rakestraw SL, Tompkins RG, Yarmush ML
Proc Natl Acad Sci U S A. 1990;87(11):4217-21 - PMID: 1693435 - PMCID: PMC54079

Cutaneous thermal injury alters macromolecular permeability of rat small intestine.

Carter EA, Tompkins RG, Schiffrin E, Burke JF
Surgery. 1990;107(3):335-41 - PMID: 2309150

Circulating interleukin-1 and tumor necrosis factor in septic shock and experimental endotoxin fever.

Cannon JG, Tompkins RG, Gelfand JA, Michie HR, Stanford GG, van der Meer JW, Endres S, Lonnemann G, Corsetti J, Chernow B
J Infect Dis. 1990;161(1):79-84 - PMID: 2295861

Autoradiographic method for quantitation of radiolabeled proteins in tissues using indium-111.

Morrell EM, Tompkins RG, Fischman AJ, Wilkinson RA, Burke JF, Rubin RH, Strauss HW, Yarmush ML
J Nucl Med. 1989;30(9):1538-45 - PMID: 2504892

Increased survival after massive thermal injuries in adults: preliminary report using artificial skin.

Tompkins RG, Hilton JF, Burke JF, Schoenfeld DA, Hegarty MT, Bondoc CC, Quinby WC, Behringer GE, Ackroyd FW
Crit Care Med. 1989;17(8):734-40 - PMID: 2546715

Low-density lipoprotein transport in blood vessel walls of squirrel monkeys.

Tompkins RG, Yarmush ML, Schnitzer JJ, Colton CK, Smith KA, Stemerman MB
Am J Physiol. 1989;257(2 Pt 2):H452-64 - PMID: 2764130

Macromolecular transport within heart valves.

Tompkins RG, Schnitzer JJ, Yarmush ML
Circ Res. 1989;64(6):1213-23 - PMID: 2720921

Occult gastrointestinal bleeding: newer techniques and diagnosis and therapy.

Moncure AC, Tompkins RG, Athanasoulis CA, Welch CE
Adv Surg. 1989;22:141-77 - PMID: 2645744

Inhibition of in vivo DNA synthesis in regenerating rat liver following thermal injury.

Carter EA, Kirkham SE, Tompkins RG, Burke JF
Biochem Biophys Res Commun. 1989;160(1):196-201 - PMID: 2785385

Hepatic and intestinal blood flow following thermal injury.

Carter EA, Tompkins RG, Burke JF
J Burn Care Rehabil. 1989;9(4):347-50 - PMID: 3220848

Hepatocyte function and extracellular matrix geometry: long-term culture in a sandwich configuration.

Dunn JC, Yarmush ML, Koebe HG, Tompkins RG
FASEB J. 1989;3(2):174-7 - PMID: 2914628

Significant reductions in mortality for children with burn injuries through the use of prompt eschar excision.

Tompkins RG, Remensnyder JP, Burke JF, Tompkins DM, Hilton JF, Schoenfeld DA, Behringer GE, Bondoc CC, Briggs SE, Quinby WC
Ann Surg. 1988;208(5):577-85 - PMID: 3190284 - PMCID: PMC1493782

Redistribution of blood flow after thermal injury and hemorrhagic shock.

Carter EA, Tompkins RG, Yarmush ML, Walker WA, Burke JF
J Appl Physiol. 1988;65(4):1782-8 - PMID: 3182540

Measurement of 125I-low density lipoprotein uptake in selected tissues of the squirrel monkey by quantitative autoradiography.

Tompkins RG, Schnitzer JJ, Yarmush ML, Colton CK, Smith KA
Am J Pathol. 1988;132(3):526-42 - PMID: 3414782 - PMCID: PMC1880767

Rectal necrosis after pelvic crush injury.

Tompkins RG, McCabe CJ, Burke JF, Keating MA, Wright CD
J Trauma. 1988;28(5):697-9 - PMID: 3367418

Increase of sialyltransferase activity in the small intestine following thermal injury in rats.

Ch SW, Carter EA, Tompkins RG, Burke JF
Biochem Biophys Res Commun. 1988;153(1):377-81 - PMID: 3259879

Enzymatic function of alginate immobilized rat hepatocytes.

Tompkins RG, Carter EA, Carlson JD, Yarmush ML
Biotechnol Bioeng. 1988;31(1):11-8 - PMID: 18581557

Burn therapy 1985: acute management.

Tompkins RG, Burke JF
Intensive Care Med. 1986;12(4):289-95 - PMID: 3531277

Prompt eschar excision: a treatment system contributing to reduced burn mortality. A statistical evaluation of burn care at the Massachusetts General Hospital (1974-1984).

Tompkins RG, Burke JF, Schoenfeld DA, Bondoc CC, Quinby WC, Behringer GC, Ackroyd FW
Ann Surg. 1986;204(3):272-81 - PMID: 3753058 - PMCID: PMC1251276

Improved management of the perineal wound after proctectomy.

Tompkins RG, Warshaw AL
Ann Surg. 1985;202(6):760-5 - PMID: 4073988 - PMCID: PMC1251011

Regional in vitro uptake of a synthetic 3H-labeled-melanin into rat brain.

Porter JR, Kastin AJ, Pelle-Day G, Tompkins RG
Brain Res Bull. 1978;2(6):401-4 - PMID: 606338

Melanin in the rat brain.

Kastin AJ, Kuzemchak B, Tompkins RG, Schally AV, Miller MC
Brain Res Bull. 1977;1(6):567-72 - PMID: 1021212

Early and late hemodynamic effects of mitral commissurotomy.

LYONS WS, TOMPKINS RG, KIRKLIN JW, WOOD EH
J Lab Clin Med. 1959;53(4):499-516 - PMID: 13654887

Quantitation of beat-to-beat changes in stroke volume from the aortic pulse contour in man.

WARNER HR, SWAN HJ, CONNOLLY DC, TOMPKINS RG, WOOD EH
J Appl Physiol. 1953;5(9):495-507 - PMID: 13034677

Surgical treatment of infundibular stenosis with intact ventricular septum.

KIRKLIN JW, OPENSHAW CR, TOMPKINS RG
Ann Surg. 1953;137(2):228-31 - PMID: 13017523 - PMCID: PMC1802459

Pulmonary artery wedge pressures in mitral valve disease; relationship to left atrial pressures.

CONNOLLY DC, TOMPKINS RG, LEV R, KIRKLIN JW, WOOD EH
Proc Staff Meet Mayo Clin. 1953;28(3):72-8 - PMID: 13014128