Center for Computational and Integrative Biology
About our Center
Faculty in the Center for Computational and Integrative Biology (CCIB) apply interdisciplinary approaches and new technologies to answer enduring biological questions and provide insights into human disease. Novel chemical, genomics and computational tools are developed to probe signaling pathways, identify mediators of host-microbe interactions, and design therapeutic disease interventions. Center investigators also conduct translational research to explore the potential utility of early-stage drug candidates in phase 1 studies carried out in small populations of individuals with the target disease indication.
The CCIB provides support for investigators at Mass General Hospital and across the greater Boston area through a variety of autonomous cores that provide services in DNA sequencing, oligonucleotide synthesis and research laboratory automation.
In the News
Publications
Gut microbiome and metabolome profiling in Framingham heart study reveals cholesterol-metabolizing bacteria. Cell. 2024;187(8):1834-1852.e19
Translational genetics identifies a phosphorylation switch in CARD9 required for innate inflammatory responses. Cell Rep. 2024;43(3):113944
Hypoxia-inducible factor induces cysteine dioxygenase and promotes cysteine homeostasis in Caenorhabditis elegans. Elife. 2024;12:ePub
Hypoxia and intra-complex genetic suppressors rescue complex I mutants by a shared mechanism. Cell. 2024;187(3):659-675.e18
Trivalent rare earth metal cofactors confer rapid NP-DNA polymerase activity. Science. 2023;382(6669):423-429
Identification of host regulators of Mycobacterium tuberculosis phenotypes uncovers a role for the MMGT1-GPR156 lipid droplet axis in persistence. Cell Host Microbe. 2023;31(6):978-992.e5
Centenarians have a diverse gut virome with the potential to modulate metabolism and promote healthy lifespan. Nat Microbiol. 2023;8(6):1064-1078
Association of distinct microbial signatures with premalignant colorectal adenomas. Cell Host Microbe. 2023;31(5):827-838.e3
Genome-wide tiled detection of circulating Mycobacterium tuberculosis cell-free DNA using Cas13. Nat Commun. 2023;14(1):1803
Remodeling of colon plasma cell repertoire within ulcerative colitis patients. J Exp Med. 2023;220(4):ePub
The landscape of immune dysregulation in Crohn's disease revealed through single-cell transcriptomic profiling in the ileum and colon. Immunity. 2023;56(2):444-458.e5
Bacterial droplet-based single-cell RNA-seq reveals antibiotic-associated heterogeneous cellular states. Cell. 2023;186(4):877-891.e14
The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways. Proc Natl Acad Sci U S A. 2022;119(49):e2215966119
Phase 2 Trial of Baxdrostat for Treatment-Resistant Hypertension. N Engl J Med. 2022;388(5):395-405
Engineered CRISPR prime editors with compact, untethered reverse transcriptases. Nat Biotechnol. 2022;41(3):337-343
NIN-like protein 7 transcription factor is a plant nitrate sensor. Science. 2022;377(6613):1419-1425
