• Subtelny AO, Hartman MC, Szostak JW Optimal codon choice can improve the efficiency and fidelity of N-methyl amino acid incorporation into peptides by in-vitro translation. Angew Chem Int Ed Engl. 2011;50(14):3164-7 - PMID: 21381166 - PMCID: PMC4006073 - DOI: 10.1002/anie.201007686

  • Budin I, Szostak JW Physical effects underlying the transition from primitive to modern cell membranes. Proc Natl Acad Sci U S A. 2011;108(13):5249-54 - PMID: 21402937 - PMCID: PMC3069173 - DOI: 10.1073/pnas.1100498108

  • Seebeck FP, Ricardo A, Szostak JW Artificial lantipeptides from in vitro translations. Chem Commun (Camb). 2011;47(21):6141-3 - PMID: 21528125 - DOI: 10.1039/c0cc05663d

  • Trevino SG, Zhang N, Elenko MP, Lupták A, Szostak JW Evolution of functional nucleic acids in the presence of nonheritable backbone heterogeneity. Proc Natl Acad Sci U S A. 2011;108(33):13492-7 - PMID: 21825162 - PMCID: PMC3158193 - DOI: 10.1073/pnas.1107113108

  • Szostak JW An optimal degree of physical and chemical heterogeneity for the origin of life?. Philos Trans R Soc Lond B Biol Sci. 2011;366(1580):2894-901 - PMID: 21930580 - PMCID: PMC3158921 - DOI: 10.1098/rstb.2011.0140

  • Budin I, Szostak JW Expanding roles for diverse physical phenomena during the origin of life. Annu Rev Biophys. 2010;39:245-63 - PMID: 20192779 - PMCID: PMC4992673 - DOI: 10.1146/annurev.biophys.050708.133753

  • Rajamani S, Ichida JK, Antal T, Treco DA, Leu K, Nowak MA, Szostak JW, Chen IA Effect of stalling after mismatches on the error catastrophe in nonenzymatic nucleic acid replication. J Am Chem Soc. 2010;132(16):5880-5 - PMID: 20359213 - PMCID: PMC2857888 - DOI: 10.1021/ja100780p

  • Schrum JP, Zhu TF, Szostak JW The origins of cellular life. Cold Spring Harb Perspect Biol. 2010;2(9):a002212 - PMID: 20484387 - PMCID: PMC2926753 - DOI: 10.1101/cshperspect.a002212

  • Elenko MP, Szostak JW, van Oijen AM Single-molecule binding experiments on long time scales. Rev Sci Instrum. 2010;81(8):083705 - PMID: 20815611 - DOI: 10.1063/1.3473936

  • Szostak JW DNA ends: just the beginning (Nobel lecture). Angew Chem Int Ed Engl. 2010;49(41):7386-404 - PMID: 20818632 - DOI: 10.1002/anie.201000635

  • Powner MW, Sutherland JD, Szostak JW Chemoselective multicomponent one-pot assembly of purine precursors in water. J Am Chem Soc. 2010;132(46):16677-88 - PMID: 21043502 - PMCID: PMC2984373 - DOI: 10.1021/ja108197s

  • Chen JJ, Cai X, Szostak JW N2'-->p3' phosphoramidate glycerol nucleic acid as a potential alternative genetic system. J Am Chem Soc. 2009;131(6):2119-21 - PMID: 19166350 - PMCID: PMC2722806 - DOI: 10.1021/ja809069b

  • Chen JJ, Tsai CH, Cai X, Horhota AT, McLaughlin LW, Szostak JW Enzymatic primer-extension with glycerol-nucleoside triphosphates on DNA templates. PLoS One. 2009;4(3):e4949 - PMID: 19305495 - PMCID: PMC2654545 - DOI: 10.1371/journal.pone.0004949

  • Zhu TF, Szostak JW Coupled growth and division of model protocell membranes. J Am Chem Soc. 2009;131(15):5705-13 - PMID: 19323552 - PMCID: PMC2669828 - DOI: 10.1021/ja900919c

  • Zhu TF, Szostak JW Preparation of large monodisperse vesicles. PLoS One. 2009;4(4):e5009 - PMID: 19347043 - PMCID: PMC2661144 - DOI: 10.1371/journal.pone.0005009

  • Litovchick A, Szostak JW Retraction for Litovchick and Szostak. "Selection of cyclic peptide aptamers to HCV IRES RNA using mRNA display". Proc Natl Acad Sci U S A. 2009;106(17):7263 - PMID: 19380733 - PMCID: PMC2678432 - DOI: 10.1073/pnas.0903110106

  • Szostak JW Origins of life: Systems chemistry on early Earth. Nature. 2009;459(7244):171-2 - PMID: 19444196 - DOI: 10.1038/459171a

  • Elenko MP, Szostak JW, van Oijen AM Single-molecule imaging of an in vitro-evolved RNA aptamer reveals homogeneous ligand binding kinetics. J Am Chem Soc. 2009;131(29):9866-7 - PMID: 19572753 - PMCID: PMC2716146 - DOI: 10.1021/ja901880v

  • Budin I, Bruckner RJ, Szostak JW Formation of protocell-like vesicles in a thermal diffusion column. J Am Chem Soc. 2009;131(28):9628-9 - PMID: 19601679 - PMCID: PMC2710859 - DOI: 10.1021/ja9029818

  • Lin S, Horning DP, Szostak JW, Chaput JC Conformational analysis of DNA repair intermediates by time-resolved fluorescence spectroscopy. J Phys Chem A. 2009;113(35):9585-7 - PMID: 19673467 - PMCID: PMC2733762 - DOI: 10.1021/jp906746w

  • Ricardo A, Szostak JW Origin of life on earth. Sci Am. 2009;301(3):54-61 - PMID: 19708528 - DOI: 10.1038/scientificamerican0909-54

  • Mansy SS, Szostak JW Reconstructing the emergence of cellular life through the synthesis of model protocells. Cold Spring Harb Symp Quant Biol. 2009;74:47-54 - PMID: 19734203 - DOI: 10.1101/sqb.2009.74.014

  • Schrum JP, Ricardo A, Krishnamurthy M, Blain JC, Szostak JW Efficient and rapid template-directed nucleic acid copying using 2'-amino-2',3'-dideoxyribonucleoside-5'-phosphorimidazolide monomers. J Am Chem Soc. 2009;131(40):14560-70 - PMID: 19757789 - PMCID: PMC2759813 - DOI: 10.1021/ja906557v

  • Bruckner RJ, Mansy SS, Ricardo A, Mahadevan L, Szostak JW Flip-flop-induced relaxation of bending energy: implications for membrane remodeling. Biophys J. 2009;97(12):3113-22 - PMID: 20006948 - PMCID: PMC2793357 - DOI: 10.1016/j.bpj.2009.09.025

  • Monnard PA, Szostak JW Metal-ion catalyzed polymerization in the eutectic phase in water-ice: a possible approach to template-directed RNA polymerization. J Inorg Biochem. 2008;102(5-6):1104-11 - PMID: 18329104 - DOI: 10.1016/j.jinorgbio.2008.01.026

  • Subtelny AO, Hartman MC, Szostak JW Ribosomal synthesis of N-methyl peptides. J Am Chem Soc. 2008;130(19):6131-6 - PMID: 18402453 - PMCID: PMC2728122 - DOI: 10.1021/ja710016v

  • Mansy SS, Schrum JP, Krishnamurthy M, Tobé S, Treco DA, Szostak JW Template-directed synthesis of a genetic polymer in a model protocell. Nature. 2008;454(7200):122-5 - PMID: 18528332 - PMCID: PMC2743009 - DOI: 10.1038/nature07018

  • Mansy SS, Szostak JW Thermostability of model protocell membranes. Proc Natl Acad Sci U S A. 2008;105(36):13351-5 - PMID: 18768808 - PMCID: PMC2528865 - DOI: 10.1073/pnas.0805086105

  • Litovchick A, Szostak JW Selection of cyclic peptide aptamers to HCV IRES RNA using mRNA display. Proc Natl Acad Sci U S A. 2008;105(40):15293-8 - PMID: 18824687 - PMCID: PMC2556359 - DOI: 10.1073/pnas.0805837105

  • Meena , Sam M, Pierce K, Szostak JW, McLaughlin LW 2',3'-Dideoxy-3'-thionucleoside triphosphates: syntheses and polymerase substrate activities. Org Lett. 2007;9(6):1161-3 - PMID: 17319676 - DOI: 10.1021/ol070147w

  • Hazen RM, Griffin PL, Carothers JM, Szostak JW Functional information and the emergence of biocomplexity. Proc Natl Acad Sci U S A. 2007;104 Suppl 1:8574-81 - PMID: 17494745 - PMCID: PMC1876432 - DOI: 10.1073/pnas.0701744104

  • Smith MD, Rosenow MA, Wang M, Allen JP, Szostak JW, Chaput JC Structural insights into the evolution of a non-biological protein: importance of surface residues in protein fold optimization. PLoS One. 2007;2(5):e467 - PMID: 17520026 - PMCID: PMC1867856 - DOI: 10.1371/journal.pone.0000467

  • Mansy SS, Zhang J, Kümmerle R, Nilsson M, Chou JJ, Szostak JW, Chaput JC Structure and evolutionary analysis of a non-biological ATP-binding protein. J Mol Biol. 2007;371(2):501-13 - PMID: 17583732 - DOI: 10.1016/j.jmb.2007.05.062

  • Seelig B, Szostak JW Selection and evolution of enzymes from a partially randomized non-catalytic scaffold. Nature. 2007;448(7155):828-31 - PMID: 17700701 - PMCID: PMC4476047 - DOI: 10.1038/nature06032

  • Tsai CH, Chen J, Szostak JW Enzymatic synthesis of DNA on glycerol nucleic acid templates without stable duplex formation between product and template. Proc Natl Acad Sci U S A. 2007;104(37):14598-603 - PMID: 17785419 - PMCID: PMC1976233 - DOI: 10.1073/pnas.0704211104

  • Hartman MC, Josephson K, Lin CW, Szostak JW An expanded set of amino acid analogs for the ribosomal translation of unnatural peptides. PLoS One. 2007;2(10):e972 - PMID: 17912351 - PMCID: PMC1989143 - DOI: 10.1371/journal.pone.0000972

  • Cho GS, Szostak JW Directed evolution of ATP binding proteins from a zinc finger domain by using mRNA display. Chem Biol. 2006;13(2):139-47 - PMID: 16492562 - DOI: 10.1016/j.chembiol.2005.10.015

  • Carothers JM, Davis JH, Chou JJ, Szostak JW Solution structure of an informationally complex high-affinity RNA aptamer to GTP. RNA. 2006;12(4):567-79 - PMID: 16510427 - PMCID: PMC1421093 - DOI: 10.1261/rna.2251306

  • Hartman MC, Josephson K, Szostak JW Enzymatic aminoacylation of tRNA with unnatural amino acids. Proc Natl Acad Sci U S A. 2006;103(12):4356-61 - PMID: 16537388 - PMCID: PMC1450175 - DOI: 10.1073/pnas.0509219103

  • Seebeck FP, Szostak JW Ribosomal synthesis of dehydroalanine-containing peptides. J Am Chem Soc. 2006;128(22):7150-1 - PMID: 16734454 - PMCID: PMC2572134 - DOI: 10.1021/ja060966w

  • Carothers JM, Oestreich SC, Szostak JW Aptamers selected for higher-affinity binding are not more specific for the target ligand. J Am Chem Soc. 2006;128(24):7929-37 - PMID: 16771507 - PMCID: PMC4287982 - DOI: 10.1021/ja060952q

  • Salehi-Ashtiani K, Lupták A, Litovchick A, Szostak JW A genomewide search for ribozymes reveals an HDV-like sequence in the human CPEB3 gene. Science. 2006;313(5794):1788-92 - PMID: 16990549 - DOI: 10.1126/science.1129308

  • Blackburn EH, Greider CW, Szostak JW Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging. Nat Med. 2006;12(10):1133-8 - PMID: 17024208 - DOI: 10.1038/nm1006-1133

  • Horhota AT, Szostak JW, McLaughlin LW Glycerol nucleoside triphosphates: synthesis and polymerase substrate activities. Org Lett. 2006;8(23):5345-7 - PMID: 17078714 - DOI: 10.1021/ol062232u

  • Shen X, Valencia CA, Szostak JW, Szostak J, Dong B, Liu R Scanning the human proteome for calmodulin-binding proteins. Proc Natl Acad Sci U S A. 2005;102(17):5969-74 - PMID: 15840729 - PMCID: PMC1087907 - DOI: 10.1073/pnas.0407928102

  • Chen IA, Salehi-Ashtiani K, Szostak JW RNA catalysis in model protocell vesicles. J Am Chem Soc. 2005;127(38):13213-9 - PMID: 16173749 - PMCID: PMC5072289 - DOI: 10.1021/ja051784p

  • Ichida JK, Zou K, Horhota A, Yu B, McLaughlin LW, Szostak JW An in vitro selection system for TNA. J Am Chem Soc. 2005;127(9):2802-3 - PMID: 15740086 - PMCID: PMC5072288 - DOI: 10.1021/ja045364w

  • Horhota A, Zou K, Ichida JK, Yu B, McLaughlin LW, Szostak JW, Chaput JC Kinetic analysis of an efficient DNA-dependent TNA polymerase. J Am Chem Soc. 2005;127(20):7427-34 - PMID: 15898792 - PMCID: PMC5042361 - DOI: 10.1021/ja0428255

  • Plummer KA, Carothers JM, Yoshimura M, Szostak JW, Verdine GL In vitro selection of RNA aptamers against a composite small molecule-protein surface. Nucleic Acids Res. 2005;33(17):5602-10 - PMID: 16199752 - PMCID: PMC1240114 - DOI: 10.1093/nar/gki867

  • Sacerdote MG, Szostak JW Semipermeable lipid bilayers exhibit diastereoselectivity favoring ribose. Proc Natl Acad Sci U S A. 2005;102(17):6004-8 - PMID: 15831588 - PMCID: PMC556129 - DOI: 10.1073/pnas.0408440102

  • Ichida JK, Horhota A, Zou K, McLaughlin LW, Szostak JW High fidelity TNA synthesis by Therminator polymerase. Nucleic Acids Res. 2005;33(16):5219-25 - PMID: 16157867 - PMCID: PMC1214552 - DOI: 10.1093/nar/gki840

  • Fujikawa SM, Chen IA, Szostak JW Shrink-wrap vesicles. Langmuir. 2005;21(26):12124-9 - PMID: 16342983 - PMCID: PMC2548281 - DOI: 10.1021/la052590q

  • Zou K, Horhota A, Yu B, Szostak JW, McLaughlin LW Synthesis of alpha-L-threofuranosyl nucleoside triphosphates (tNTPs). Org Lett. 2005;7(8):1485-7 - PMID: 15816733 - PMCID: PMC5022784 - DOI: 10.1021/ol050081+

  • Josephson K, Hartman MC, Szostak JW Ribosomal synthesis of unnatural peptides. J Am Chem Soc. 2005;127(33):11727-35 - PMID: 16104750 - DOI: 10.1021/ja0515809

  • Chaput JC, Szostak JW Evolutionary optimization of a nonbiological ATP binding protein for improved folding stability. Chem Biol. 2004;11(6):865-74 - PMID: 15217619 - DOI: 10.1016/j.chembiol.2004.04.006

  • Hanczyc MM, Szostak JW Replicating vesicles as models of primitive cell growth and division. Curr Opin Chem Biol. 2004;8(6):660-4 - PMID: 15556412 - DOI: 10.1016/j.cbpa.2004.10.002

  • Chen IA, Szostak JW Membrane growth can generate a transmembrane pH gradient in fatty acid vesicles. Proc Natl Acad Sci U S A. 2004;101(21):7965-70 - PMID: 15148394 - PMCID: PMC419540 - DOI: 10.1073/pnas.0308045101

  • Chen IA, Roberts RW, Szostak JW The emergence of competition between model protocells. Science. 2004;305(5689):1474-6 - PMID: 15353806 - PMCID: PMC4484590 - DOI: 10.1126/science.1100757

  • Chen IA, Szostak JW A kinetic study of the growth of fatty acid vesicles. Biophys J. 2004;87(2):988-98 - PMID: 15298905 - PMCID: PMC1304506 - DOI: 10.1529/biophysj.104.039875

  • Carothers JM, Oestreich SC, Davis JH, Szostak JW Informational complexity and functional activity of RNA structures. J Am Chem Soc. 2004;126(16):5130-7 - PMID: 15099096 - PMCID: PMC5042360 - DOI: 10.1021/ja031504a

  • Sazani PL, Larralde R, Szostak JW A small aptamer with strong and specific recognition of the triphosphate of ATP. J Am Chem Soc. 2004;126(27):8370-1 - PMID: 15237981 - PMCID: PMC4983724 - DOI: 10.1021/ja049171k

  • Szostak JW Functional information: Molecular messages. Nature. 2003;423(6941):689 - PMID: 12802312 - DOI: 10.1038/423689a

  • Huang Z, Szostak JW Evolution of aptamers with a new specificity and new secondary structures from an ATP aptamer. RNA. 2003;9(12):1456-63 - PMID: 14624002 - PMCID: PMC1370500 - DOI: 10.1261/rna.5990203

  • Chaput JC, Ichida JK, Szostak JW DNA polymerase-mediated DNA synthesis on a TNA template. J Am Chem Soc. 2003;125(4):856-7 - PMID: 12537469 - DOI: 10.1021/ja028589k

  • Vaish NK, Larralde R, Fraley AW, Szostak JW, McLaughlin LW A novel, modification-dependent ATP-binding aptamer selected from an RNA library incorporating a cationic functionality. Biochemistry. 2003;42(29):8842-51 - PMID: 12873145 - DOI: 10.1021/bi027354i

  • Huang Z, Szostak JW Selective labeling and detection of specific RNAs in an RNA mixture. Anal Biochem. 2003;315(1):129-33 - PMID: 12672421 - DOI: 10.1016/s0003-2697(02)00701-7

  • Hanczyc MM, Fujikawa SM, Szostak JW Experimental models of primitive cellular compartments: encapsulation, growth, and division. Science. 2003;302(5645):618-22 - PMID: 14576428 - PMCID: PMC4484575 - DOI: 10.1126/science.1089904

  • Chaput JC, Szostak JW TNA synthesis by DNA polymerases. J Am Chem Soc. 2003;125(31):9274-5 - PMID: 12889939 - DOI: 10.1021/ja035917n

  • Szostak JW Molecular biology: RNA gets a grip on translation. Nature. 2002;419(6910):890-1 - PMID: 12410294 - DOI: 10.1038/419890a

  • Baggio R, Burgstaller P, Hale SP, Putney AR, Lane M, Lipovsek D, Wright MC, Roberts RW, Liu R, Szostak JW, Wagner RW Identification of epitope-like consensus motifs using mRNA display. J Mol Recognit. 2002;15(3):126-34 - PMID: 12203838 - DOI: 10.1002/jmr.567

  • Davis JH, Szostak JW Isolation of high-affinity GTP aptamers from partially structured RNA libraries. Proc Natl Acad Sci U S A. 2002;99(18):11616-21 - PMID: 12185247 - PMCID: PMC129318 - DOI: 10.1073/pnas.182095699

  • Keefe AD, Wilson DS, Seelig B, Szostak JW One-step purification of recombinant proteins using a nanomolar-affinity streptavidin-binding peptide, the SBP-Tag. Protein Expr Purif. 2001;23(3):440-6 - PMID: 11722181 - DOI: 10.1006/prep.2001.1515

  • Keefe AD, Szostak JW Functional proteins from a random-sequence library. Nature. 2001;410(6829):715-8 - PMID: 11287961 - PMCID: PMC4476321 - DOI: 10.1038/35070613

  • Salehi-Ashtiani K, Szostak JW In vitro evolution suggests multiple origins for the hammerhead ribozyme. Nature. 2001;414(6859):82-4 - PMID: 11689947 - DOI: 10.1038/35102081

  • Szostak JW, Bartel DP, Luisi PL Synthesizing life. Nature. 2001;409(6818):387-90 - PMID: 11201752 - DOI: 10.1038/35053176

  • Wilson DS, Keefe AD, Szostak JW The use of mRNA display to select high-affinity protein-binding peptides. Proc Natl Acad Sci U S A. 2001;98(7):3750-5 - PMID: 11274392 - PMCID: PMC31124 - DOI: 10.1073/pnas.061028198

  • Szostak JW In vitro selection and directed evolution. Harvey Lect. 2000;93:95-118 - PMID: 10941421

  • Wilson DS, Szostak JW In vitro selection of functional nucleic acids. Annu Rev Biochem. 2000;68:611-47 - PMID: 10872462 - DOI: 10.1146/annurev.biochem.68.1.611

  • Cho G, Keefe AD, Liu R, Wilson DS, Szostak JW Constructing high complexity synthetic libraries of long ORFs using in vitro selection. J Mol Biol. 2000;297(2):309-19 - PMID: 10715203 - DOI: 10.1006/jmbi.2000.3571

  • Vaish NK, Fraley AW, Szostak JW, McLaughlin LW Expanding the structural and functional diversity of RNA: analog uridine triphosphates as candidates for in vitro selection of nucleic acids. Nucleic Acids Res. 2000;28(17):3316-22 - PMID: 10954600 - PMCID: PMC110695 - DOI: 10.1093/nar/28.17.3316

  • Lee N, Bessho Y, Wei K, Szostak JW, Suga H Ribozyme-catalyzed tRNA aminoacylation. Nat Struct Biol. 2000;7(1):28-33 - PMID: 10625423 - DOI: 10.1038/71225

  • Liu R, Barrick JE, Szostak JW, Roberts RW Optimized synthesis of RNA-protein fusions for in vitro protein selection. Methods Enzymol. 2000;318:268-93 - PMID: 10889994 - DOI: 10.1016/s0076-6879(00)18058-9

  • Holeman LA, Robinson SL, Szostak JW, Wilson C Isolation and characterization of fluorophore-binding RNA aptamers. Fold Des. 1999;3(6):423-31 - PMID: 9889155 - DOI: 10.1016/S1359-0278(98)00059-5

  • Suga H, Lohse PA, Szostak JW Structural and kinetic characterization of an acyl transferase ribozyme. J Am Chem Soc. 1998;120(6):1151-6 - PMID: 11541113 - DOI: 10.1021/ja972472s

  • Suga H, Cowan JA, Szostak JW Unusual metal ion catalysis in an acyl-transferase ribozyme. Biochemistry. 1998;37(28):10118-25 - PMID: 9665717 - DOI: 10.1021/bi980432a

  • Wilson C, Szostak JW Isolation of a fluorophore-specific DNA aptamer with weak redox activity. Chem Biol. 1998;5(11):609-17 - PMID: 9831529 - DOI: 10.1016/s1074-5521(98)90289-7

  • Hager AJ, Szostak JW Isolation of novel ribozymes that ligate AMP-activated RNA substrates. Chem Biol. 1997;4(8):607-17 - PMID: 9281527 - DOI: 10.1016/s1074-5521(97)90246-5

  • Szostak JW Introduction: Combinatorial Chemistry. Chem Rev. 1997;97(2):347-348 - PMID: 11848873 - DOI: 10.1021/cr9700080

  • Roberts RW, Szostak JW RNA-peptide fusions for the in vitro selection of peptides and proteins. Proc Natl Acad Sci U S A. 1997;94(23):12297-302 - PMID: 9356443 - PMCID: PMC24913 - DOI: 10.1073/pnas.94.23.12297

  • Dieckmann T, Butcher SE, Sassanfar M, Szostak JW, Feigon J Mutant ATP-binding RNA aptamers reveal the structural basis for ligand binding. J Mol Biol. 1997;273(2):467-78 - PMID: 9344753 - DOI: 10.1006/jmbi.1997.1329

  • Chapman KB, Szostak JW In vitro selection of catalytic RNAs. Curr Opin Struct Biol. 1997;4:618-22 - PMID: 11539575 - DOI: 10.1016/s0959-440x(94)90227-5

  • Hager AJ, Pollard JD, Szostak JW Ribozymes: aiming at RNA replication and protein synthesis. Chem Biol. 1996;3(9):717-25 - PMID: 8939686 - DOI: 10.1016/s1074-5521(96)90246-x

  • Rohatgi R, Bartel DP, Szostak JW Kinetic and mechanistic analysis of nonenzymatic, template-directed oligoribonucleotide ligation. J Am Chem Soc. 1996;118(14):3332-9 - PMID: 11539267 - DOI: 10.1021/ja953712b

  • Lohse PA, Szostak JW Ribozyme-catalysed amino-acid transfer reactions. Nature. 1996;381(6581):442-4 - PMID: 8632803 - DOI: 10.1038/381442a0

  • Lorsch JR, Szostak JW Chance and necessity in the selection of nucleic acid catalysts. Acc Chem Res. 1996;29(2):103-10 - PMID: 11539421 - DOI: 10.1021/ar9501378

  • Huang Z, Szostak JW A simple method for 3'-labeling of RNA. Nucleic Acids Res. 1996;24(21):4360-1 - PMID: 8932396 - PMCID: PMC146232 - DOI: 10.1093/nar/24.21.4360

  • Rohatgi R, Bartel DP, Szostak JW Nonenzymatic, template-directed ligation of oligoribonucleotides is highly regioselective for the formation of 3'-5' phosphodiester bonds. J Am Chem Soc. 1996;118(14):3340-4 - PMID: 11539268 - DOI: 10.1021/ja9537134

  • Cuenoud B, Szostak JW A DNA metalloenzyme with DNA ligase activity. Nature. 1995;375(6532):611-4 - PMID: 7791880 - DOI: 10.1038/375611a0

  • Chapman KB, Szostak JW Isolation of a ribozyme with 5'-5' ligase activity. Chem Biol. 1995;2(5):325-33 - PMID: 9383434 - DOI: 10.1016/1074-5521(95)90051-9

  • Ekland EH, Szostak JW, Bartel DP Structurally complex and highly active RNA ligases derived from random RNA sequences. Science. 1995;269(5222):364-70 - PMID: 7618102 - DOI: 10.1126/science.7618102

  • Whoriskey SK, Usman N, Szostak JW Total chemical synthesis of a ribozyme derived from a group I intron. Proc Natl Acad Sci U S A. 1995;92(7):2465-9 - PMID: 7708666 - PMCID: PMC42238 - DOI: 10.1073/pnas.92.7.2465

  • Lorsch JR, Bartel DP, Szostak JW Reverse transcriptase reads through a 2'-5'linkage and a 2'-thiophosphate in a template. Nucleic Acids Res. 1995;23(15):2811-4 - PMID: 7544885 - PMCID: PMC307115 - DOI: 10.1093/nar/23.15.2811

  • Lorsch JR, Szostak JW Kinetic and thermodynamic characterization of the reaction catalyzed by a polynucleotide kinase ribozyme. Biochemistry. 1995;34(46):15315-27 - PMID: 7578148 - DOI: 10.1021/bi00046a041

  • Huizenga DE, Szostak JW A DNA aptamer that binds adenosine and ATP. Biochemistry. 1995;34(2):656-65 - PMID: 7819261 - DOI: 10.1021/bi00002a033

  • Wilson C, Szostak JW In vitro evolution of a self-alkylating ribozyme. Nature. 1995;374(6525):777-82 - PMID: 7723823 - DOI: 10.1038/374777a0

  • Lauhon CT, Szostak JW RNA aptamers that bind flavin and nicotinamide redox cofactors. J Am Chem Soc. 1995;117(4):1246-57 - PMID: 11539282 - DOI: 10.1021/ja00109a008

  • Lorsch JR, Szostak JW In vitro evolution of new ribozymes with polynucleotide kinase activity. Nature. 1994;371(6492):31-6 - PMID: 7521014 - DOI: 10.1038/371031a0

  • Hanna M, Szostak JW Suppression of mutations in the core of the Tetrahymena ribozyme by spermidine, ethanol and by substrate stabilization. Nucleic Acids Res. 1994;22(24):5326-31 - PMID: 7816622 - PMCID: PMC332078 - DOI: 10.1093/nar/22.24.5326

  • Lin CW, Hanna M, Szostak JW Evidence that the guanosine substrate of the Tetrahymena ribozyme is bound in the anti conformation and that N7 contributes to binding. Biochemistry. 1994;33(9):2703-7 - PMID: 8117735 - DOI: 10.1021/bi00175a045

  • Peterson RD, Bartel DP, Szostak JW, Horvath SJ, Feigon J 1H NMR studies of the high-affinity Rev binding site of the Rev responsive element of HIV-1 mRNA: base pairing in the core binding element. Biochemistry. 1994;33(18):5357-66 - PMID: 8180157 - DOI: 10.1021/bi00184a001

  • Green R, Szostak JW In vitro genetic analysis of the hinge region between helical elements P5-P4-P6 and P7-P3-P8 in the sunY group I self-splicing intron. J Mol Biol. 1994;235(1):140-55 - PMID: 7507168 - DOI: 10.1016/s0022-2836(05)80022-1

  • Lorsch JR, Szostak JW In vitro selection of RNA aptamers specific for cyanocobalamin. Biochemistry. 1994;33(4):973-82 - PMID: 7508262 - DOI: 10.1021/bi00170a016

  • Sassanfar M, Szostak JW An RNA motif that binds ATP. Nature. 1993;364(6437):550-3 - PMID: 7687750 - DOI: 10.1038/364550a0

  • Doudna JA, Usman N, Szostak JW Ribozyme-catalyzed primer extension by trinucleotides: a model for the RNA-catalyzed replication of RNA. Biochemistry. 1993;32(8):2111-5 - PMID: 7680575 - DOI: 10.1021/bi00059a032

  • Bartel DP, Szostak JW Isolation of new ribozymes from a large pool of random sequences [see comment]. Science. 1993;261(5127):1411-8 - PMID: 7690155 - DOI: 10.1126/science.7690155

  • Szostak JW Ribozymes. Evolution ex vivo. Nature. 1993;361(6408):119-20 - PMID: 7678448 - DOI: 10.1038/361119a0

  • Ross LO, Treco D, Nicolas A, Szostak JW, Dawson D Meiotic recombination on artificial chromosomes in yeast. Genetics. 1992;131(3):541-50 - PMID: 1385793 - PMCID: PMC1205028

  • Park EC, Finley D, Szostak JW A strategy for the generation of conditional mutations by protein destabilization. Proc Natl Acad Sci U S A. 1992;89(4):1249-52 - PMID: 1311090 - PMCID: PMC48426 - DOI: 10.1073/pnas.89.4.1249

  • Szostak JW In vitro genetics. Trends Biochem Sci. 1992;17(3):89-93 - PMID: 1384177 - DOI: 10.1016/0968-0004(92)90242-2

  • Green R, Szostak JW Selection of a ribozyme that functions as a superior template in a self-copying reaction. Science. 1992;258(5090):1910-5 - PMID: 1470913 - DOI: 10.1126/science.1470913

  • Ellington AD, Szostak JW Selection in vitro of single-stranded DNA molecules that fold into specific ligand-binding structures. Nature. 1992;355(6363):850-2 - PMID: 1538766 - DOI: 10.1038/355850a0

  • Park EC, Szostak JW ARD1 and NAT1 proteins form a complex that has N-terminal acetyltransferase activity. EMBO J. 1992;11(6):2087-93 - PMID: 1600941 - PMCID: PMC556675

  • Bartel DP, Doudna JA, Usman N, Szostak JW Template-directed primer extension catalyzed by the Tetrahymena ribozyme. Mol Cell Biol. 1991;11(6):3390-4 - PMID: 2038341 - PMCID: PMC360195 - DOI: 10.1128/mcb.11.6.3390

  • Doudna JA, Couture S, Szostak JW A multisubunit ribozyme that is a catalyst of and template for complementary strand RNA synthesis. Science. 1991;251(5001):1605-8 - PMID: 1707185 - DOI: 10.1126/science.1707185

  • Pace U, Szostak JW Mutations in a semiconserved region of the Tetrahymena intron. FEBS Lett. 1991;280(1):171-4 - PMID: 2009960 - DOI: 10.1016/0014-5793(91)80230-z

  • Green R, Szostak JW, Benner SA, Rich A, Usman N Synthesis of RNA containing inosine: analysis of the sequence requirements for the 5' splice site of the Tetrahymena group I intron. Nucleic Acids Res. 1991;19(15):4161-6 - PMID: 1714564 - PMCID: PMC328556 - DOI: 10.1093/nar/19.15.4161

  • Sun H, Dawson D, Szostak JW Genetic and physical analyses of sister chromatid exchange in yeast meiosis. Mol Cell Biol. 1991;11(12):6328-36 - PMID: 1944292 - PMCID: PMC361828 - DOI: 10.1128/mcb.11.12.6328

  • Bartel DP, Zapp ML, Green MR, Szostak JW HIV-1 Rev regulation involves recognition of non-Watson-Crick base pairs in viral RNA. Cell. 1991;67(3):529-36 - PMID: 1934059 - DOI: 10.1016/0092-8674(91)90527-6

  • Schultes NP, Szostak JW A poly(dA.dT) tract is a component of the recombination initiation site at the ARG4 locus in Saccharomyces cerevisiae. Mol Cell Biol. 1991;11(1):322-8 - PMID: 1986228 - PMCID: PMC359622 - DOI: 10.1128/mcb.11.1.322

  • Sun H, Treco D, Szostak JW Extensive 3'-overhanging, single-stranded DNA associated with the meiosis-specific double-strand breaks at the ARG4 recombination initiation site. Cell. 1991;64(6):1155-61 - PMID: 2004421 - DOI: 10.1016/0092-8674(91)90270-9

  • Lichten M, Goyon C, Schultes NP, Treco D, Szostak JW, Haber JE, Nicolas A Detection of heteroduplex DNA molecules among the products of Saccharomyces cerevisiae meiosis. Proc Natl Acad Sci U S A. 1990;87(19):7653-7 - PMID: 2217196 - PMCID: PMC54806 - DOI: 10.1073/pnas.87.19.7653

  • Michel F, Ellington AD, Couture S, Szostak JW Phylogenetic and genetic evidence for base-triples in the catalytic domain of group I introns. Nature. 1990;347(6293):578-80 - PMID: 2215683 - DOI: 10.1038/347578a0

  • Schultes NP, Szostak JW Decreasing gradients of gene conversion on both sides of the initiation site for meiotic recombination at the ARG4 locus in yeast. Genetics. 1990;126(4):813-22 - PMID: 1981763 - PMCID: PMC1204280

  • Couture S, Ellington AD, Gerber AS, Cherry JM, Doudna JA, Green R, Hanna M, Pace U, Rajagopal J, Szostak JW Mutational analysis of conserved nucleotides in a self-splicing group I intron. J Mol Biol. 1990;215(3):345-58 - PMID: 1700131 - DOI: 10.1016/s0022-2836(05)80356-0

  • Ellington AD, Szostak JW In vitro selection of RNA molecules that bind specific ligands. Nature. 1990;346(6287):818-22 - PMID: 1697402 - DOI: 10.1038/346818a0

  • Green R, Ellington AD, Szostak JW In vitro genetic analysis of the Tetrahymena self-splicing intron. Nature. 1990;347(6291):406-8 - PMID: 2215650 - DOI: 10.1038/347406a0

  • Doudna JA, Szostak JW, Rich A, Usman N Chemical synthesis of oligoribonucleotides containing 2-aminopurine: substrates for the investigation of ribozyme function. J Org Chem. 1990;55(21):5547-9 - PMID: 11540922 - DOI: 10.1021/jo00308a003

  • Schultes NP, Ellington AD, Cherry JM, Szostak JW Saccharomyces cerevisiae homoserine kinase is homologous to prokaryotic homoserine kinases. Gene. 1990;96(2):177-80 - PMID: 2176637 - DOI: 10.1016/0378-1119(90)90250-u

  • Park EC, Szostak JW Point mutations in the yeast histone H4 gene prevent silencing of the silent mating type locus HML. Mol Cell Biol. 1990;10(9):4932-4 - PMID: 2117703 - PMCID: PMC361112 - DOI: 10.1128/mcb.10.9.4932

  • Michel F, Hanna M, Green R, Bartel DP, Szostak JW The guanosine binding site of the Tetrahymena ribozyme. Nature. 1989;342(6248):391-5 - PMID: 2685606 - DOI: 10.1038/342391a0

  • Sun H, Treco D, Schultes NP, Szostak JW Double-strand breaks at an initiation site for meiotic gene conversion. Nature. 1989;338(6210):87-90 - PMID: 2645528 - DOI: 10.1038/338087a0

  • Nicolas A, Treco D, Schultes NP, Szostak JW An initiation site for meiotic gene conversion in the yeast Saccharomyces cerevisiae. Nature. 1989;338(6210):35-9 - PMID: 2537472 - DOI: 10.1038/338035a0

  • Szostak JW Telomerase: the beginning of the ends. Nature. 1989;337(6205):303-4 - PMID: 2765013 - DOI: 10.1038/337303a0

  • Doudna JA, Szostak JW Miniribozymes, small derivatives of the sunY intron, are catalytically active. Mol Cell Biol. 1989;9(12):5480-3 - PMID: 2685567 - PMCID: PMC363717 - DOI: 10.1128/mcb.9.12.5480

  • Doudna JA, Cormack BP, Szostak JW RNA structure, not sequence, determines the 5' splice-site specificity of a group I intron. Proc Natl Acad Sci U S A. 1989;86(19):7402-6 - PMID: 2678103 - PMCID: PMC298070 - DOI: 10.1073/pnas.86.19.7402

  • Rajagopal J, Doudna JA, Szostak JW Stereochemical course of catalysis by the Tetrahymena ribozyme. Science. 1989;244(4905):692-4 - PMID: 2470151 - DOI: 10.1126/science.2470151

  • Lundblad V, Szostak JW A mutant with a defect in telomere elongation leads to senescence in yeast. Cell. 1989;57(4):633-43 - PMID: 2655926 - DOI: 10.1016/0092-8674(89)90132-3

  • Doudna JA, Szostak JW RNA-catalysed synthesis of complementary-strand RNA. Nature. 1989;339(6225):519-22 - PMID: 2660003 - DOI: 10.1038/339519a0

  • Doudna JA, Gerber AS, Cherry JM, Szostak JW Genetic dissection of an RNA enzyme. Cold Spring Harb Symp Quant Biol. 1988;52:173-80 - PMID: 2456876 - DOI: 10.1101/sqb.1987.052.01.022

  • Orr-Weaver TL, Nicolas A, Szostak JW Gene conversion adjacent to regions of double-strand break repair. Mol Cell Biol. 1988;8(12):5292-8 - PMID: 3072478 - PMCID: PMC365631 - DOI: 10.1128/mcb.8.12.5292

  • Allshire RC, Gosden JR, Cross SH, Cranston G, Rout D, Sugawara N, Szostak JW, Fantes PA, Hastie ND Telomeric repeat from T. thermophila cross hybridizes with human telomeres. Nature. 1988;332(6165):656-9 - PMID: 2833706 - DOI: 10.1038/332656a0

  • Murray AW, Claus TE, Szostak JW Characterization of two telomeric DNA processing reactions in Saccharomyces cerevisiae. Mol Cell Biol. 1988;8(11):4642-50 - PMID: 3062364 - PMCID: PMC365553 - DOI: 10.1128/mcb.8.11.4642

  • Whiteway M, Freedman R, Van Arsdell S, Szostak JW, Thorner J The yeast ARD1 gene product is required for repression of cryptic mating-type information at the HML locus. Mol Cell Biol. 1987;7(10):3713-22 - PMID: 3316986 - PMCID: PMC368027 - DOI: 10.1128/mcb.7.10.3713

  • Matsumoto T, Fukui K, Niwa O, Sugawara N, Szostak JW, Yanagida M Identification of healed terminal DNA fragments in linear minichromosomes of Schizosaccharomyces pombe. Mol Cell Biol. 1987;7(12):4424-30 - PMID: 2830493 - PMCID: PMC368126 - DOI: 10.1128/mcb.7.12.4424

  • Burke JM, Belfort M, Cech TR, Davies RW, Schweyen RJ, Shub DA, Szostak JW, Tabak HF Structural conventions for group I introns. Nucleic Acids Res. 1987;15(18):7217-21 - PMID: 3658691 - PMCID: PMC306243 - DOI: 10.1093/nar/15.18.7217

  • Reynolds AE, Murray AW, Szostak JW Roles of the 2 microns gene products in stable maintenance of the 2 microns plasmid of Saccharomyces cerevisiae. Mol Cell Biol. 1987;7(10):3566-73 - PMID: 3316982 - PMCID: PMC368010 - DOI: 10.1128/mcb.7.10.3566

  • Murray AW, Szostak JW Artificial chromosomes. Sci Am. 1987;257(5):62-8 - PMID: 3317814 - DOI: 10.1038/scientificamerican1187-62

  • Murray AW, Szostak JW Chromosome segregation in mitosis and meiosis. Annu Rev Cell Biol. 1987;1:289-315 - PMID: 3916318 - DOI: 10.1146/annurev.cb.01.110185.001445

  • Murray AW, Szostak JW Construction and behavior of circularly permuted and telocentric chromosomes in Saccharomyces cerevisiae. Mol Cell Biol. 1986;6(9):3166-72 - PMID: 3537731 - PMCID: PMC367052 - DOI: 10.1128/mcb.6.9.3166

  • Dawson DS, Murray AW, Szostak JW An alternative pathway for meiotic chromosome segregation in yeast. Science. 1986;234(4777):713-7 - PMID: 3535068 - DOI: 10.1126/science.3535068

  • Szostak JW Enzymatic activity of the conserved core of a group I self-splicing intron. Nature. 1986;322(6074):83-6 - PMID: 3014350 - DOI: 10.1038/322083a0

  • Murray AW, Schultes NP, Szostak JW Chromosome length controls mitotic chromosome segregation in yeast. Cell. 1986;45(4):529-36 - PMID: 3518944 - DOI: 10.1016/0092-8674(86)90284-9

  • Ruby SW, Szostak JW Specific Saccharomyces cerevisiae genes are expressed in response to DNA-damaging agents. Mol Cell Biol. 1985;5(1):75-84 - PMID: 3920512 - PMCID: PMC366680 - DOI: 10.1128/mcb.5.1.75

  • Whiteway M, Szostak JW The ARD1 gene of yeast functions in the switch between the mitotic cell cycle and alternative developmental pathways. Cell. 1985;43(2 Pt 1):483-92 - PMID: 3907857 - DOI: 10.1016/0092-8674(85)90178-3

  • Orr-Weaver TL, Szostak JW Fungal recombination. Microbiol Rev. 1985;49(1):33-58 - PMID: 3884994 - PMCID: PMC373016 - DOI: 10.1128/mr.49.1.33-58.1985

  • Shampay J, Szostak JW, Blackburn EH DNA sequences of telomeres maintained in yeast. Nature. 1984;310(5973):154-7 - PMID: 6330571 - DOI: 10.1038/310154a0

  • Dunn B, Szauter P, Pardue ML, Szostak JW Transfer of yeast telomeres to linear plasmids by recombination. Cell. 1984;39(1):191-201 - PMID: 6091911 - DOI: 10.1016/0092-8674(84)90205-8

  • Walmsley RM, Szostak JW, Petes TD Is there left-handed DNA at the ends of yeast chromosomes?. Nature. 1983;302(5903):84-6 - PMID: 6338397 - DOI: 10.1038/302084a0

  • Orr-Weaver TL, Szostak JW Multiple, tandem plasmid integration in Saccharomyces cerevisiae. Mol Cell Biol. 1983;3(4):747-9 - PMID: 6343844 - PMCID: PMC368590 - DOI: 10.1128/mcb.3.4.747

  • Sugawara N, Szostak JW Recombination between sequences in nonhomologous positions. Proc Natl Acad Sci U S A. 1983;80(18):5675-9 - PMID: 6351064 - PMCID: PMC384321 - DOI: 10.1073/pnas.80.18.5675

  • Szostak JW A rapid procedure for the construction of linear yeast plasmids. Methods Enzymol. 1983;101:245-52 - PMID: 6310327 - DOI: 10.1016/0076-6879(83)01018-6

  • Szostak JW Replication and resolution of telomeres in yeast. Cold Spring Harb Symp Quant Biol. 1983;47 Pt 2:1187-94 - PMID: 6305577 - DOI: 10.1101/sqb.1983.047.01.134

  • Orr-Weaver TL, Szostak JW, Rothstein RJ Genetic applications of yeast transformation with linear and gapped plasmids. Methods Enzymol. 1983;101:228-45 - PMID: 6310326 - DOI: 10.1016/0076-6879(83)01017-4

  • Szostak JW, Orr-Weaver TL, Rothstein RJ, Stahl FW The double-strand-break repair model for recombination. Cell. 1983;33(1):25-35 - PMID: 6380756 - DOI: 10.1016/0092-8674(83)90331-8

  • Ruby SW, Szostak JW, Murray AW Cloning regulated yeast genes from a pool of lacZ fusions. Methods Enzymol. 1983;101:253-69 - PMID: 6310328 - DOI: 10.1016/0076-6879(83)01019-8

  • Murray AW, Szostak JW Pedigree analysis of plasmid segregation in yeast. Cell. 1983;34(3):961-70 - PMID: 6354471 - DOI: 10.1016/0092-8674(83)90553-6

  • Brown PA, Szostak JW Yeast vectors with negative selection. Methods Enzymol. 1983;101:278-90 - PMID: 6310330 - DOI: 10.1016/0076-6879(83)01021-6

  • Orr-Weaver TL, Szostak JW Yeast recombination: the association between double-strand gap repair and crossing-over. Proc Natl Acad Sci U S A. 1983;80(14):4417-21 - PMID: 6308623 - PMCID: PMC384049 - DOI: 10.1073/pnas.80.14.4417

  • Murray AW, Szostak JW Construction of artificial chromosomes in yeast. Nature. 1983;305(5931):189-93 - PMID: 6350893 - DOI: 10.1038/305189a0

  • Sugawara N, Szostak JW Construction of specific chromosomal rearrangements in yeast. Methods Enzymol. 1983;101:269-78 - PMID: 6310329 - DOI: 10.1016/0076-6879(83)01020-4

  • Szostak JW, Blackburn EH Cloning yeast telomeres on linear plasmid vectors. Cell. 1982;29(1):245-55 - PMID: 6286143 - DOI: 10.1016/0092-8674(82)90109-x

  • Stiles JI, Szostak JW, Young AT, Wu R, Consaul S, Sherman F DNA sequence of a mutation in the leader region of the yeast iso-1-cytochrome c mRNA. Cell. 1981;25(1):277-84 - PMID: 6268305 - DOI: 10.1016/0092-8674(81)90253-1

  • Orr-Weaver TL, Szostak JW, Rothstein RJ Yeast transformation: a model system for the study of recombination. Proc Natl Acad Sci U S A. 1981;78(10):6354-8 - PMID: 6273866 - PMCID: PMC349037 - DOI: 10.1073/pnas.78.10.6354

  • Szostak JW, Wu R Unequal crossing over in the ribosomal DNA of Saccharomyces cerevisiae. Nature. 1980;284(5755):426-30 - PMID: 6987539 - DOI: 10.1038/284426a0

  • Szostak JW, Stiles JI, Tye BK, Chiu P, Sherman F, Wu R Hybridization with synthetic oligonucleotides. Methods Enzymol. 1980;68:419-28 - PMID: 161605 - DOI: 10.1016/0076-6879(79)68031-x

  • Szostak JW, Wu R Insertion of a genetic marker into the ribosomal DNA of yeast. Plasmid. 1979;2(4):536-54 - PMID: 394173 - DOI: 10.1016/0147-619x(79)90053-2

  • Szostak JW, Stiles JI, Bahl CP, Wu R Specific binding of a synthetic oligodeoxyribonucleotide to yeast cytochrome c mRNA. Nature. 1977;265(5589):61-3 - PMID: 189200 - DOI: 10.1038/265061a0