Sheen, Jen

Phone: 617-726-5968


Office Address:
Department of Molecular Biology
Massachusetts General Hospital
Simches Research Center, CPZN 7624E
185 Cambridge Street
Boston, MA 02114

Place of Birth: Tainai, Taiwan

1980 B.S. National Taiwan University, Botany
1986 Ph.D. Harvard University, Cellular and Developmental Biology

Academic Appointments:
1987-1999 Lecturer on Genetics, Harvard Medical School
1999-2004 Associate Professor in Genetics, Harvard Medical School
2005-present Professor in Genetics, Harvard Medical School

Hospital Appointments:
1987-1991 Departmental Fellow in Molecular Biology, Massachusetts General Hospital
1991-1999 Assistant in Molecular Biology, Massachusetts General Hospital
1999-2004 Associate Molecular Biologist, Massachusetts General Hospital
2005- present Molecular Biologist, Massachusetts General Hospital

Selected Publications (from total of 92)


Xiong Y, Sheen J
Novel links in the plant TOR kinase signaling network.
Curr Opin Plant Biol. 2015;28:83-91 - PMID: 26476687 - PMCID: PMC4612364
Li JF, Zhang D, Sheen J
Targeted Plant Genome Editing via the CRISPR/Cas9 Technology.
Methods Mol Biol. 2015;1284:239-55 - PMID: 25757776
Cheng Z, Li JF, Niu Y, Zhang XC, Woody OZ, Xiong Y, Djonovi? S, Millet Y, Bush J, McConkey BJ, Sheen J, Ausubel FM
Pathogen-secreted proteases activate a novel plant immune pathway.
Nature. 2015;521(7551):213-6 - PMID: 25731164 - PMCID: PMC4433409
Li JF, Zhang D, Sheen J
Cas9-Based Genome Editing in Arabidopsis and Tobacco.
Methods Enzymol. 2014;546C:459-472 - PMID: 25398353
Wu HY, Liu KH, Wang YC, Wu JF, Chiu WL, Chen CY, Wu SH, Sheen J, Lai EM
AGROBEST: an efficient Agrobacterium-mediated transient expression method for versatile gene function analyses in Arabidopsis seedlings.
Plant Methods. 2014;10:19 - PMID: 24987449 - PMCID: PMC4076510
Sheen J
Master Regulators in Plant Glucose Signaling Networks.
2014;57(2):67-79 - PMID: 25530701 - PMCID: PMC4270195
Li JF, Zhang D, Sheen J
Epitope-tagged protein-based artificial miRNA screens for optimized gene silencing in plants.
Nat Protoc. 2014;9(4):939-49 - PMID: 24675734 - PMCID: PMC4208271
Xiong Y, Sheen J
TOR Signaling Networks in Plant Growth and Metabolism.
Plant Physiol. 2014;164(2):499-512 - PMID: 24385567 - PMCID: PMC3912084
Hamel LP, Sheen J, S├ęguin A
Ancient signals: comparative genomics of green plant CDPKs.
Trends Plant Sci. 2013;19(2):79-89 - PMID: 24342084 - PMCID: PMC3932502
Zhou J, Wu S, Chen X, Liu C, Sheen J, Shan L, He P
Pseudomonas syringae Effector HopF2 Suppresses Arabidopsis Immunity by Targeting BAK1.
Plant J. 2013;77(2):235-45 - PMID: 24237140 - PMCID: PMC4224013
Sheen J
The cytokinin side chain commands shooting.
Dev Cell. 2013;27(4):371-2 - PMID: 24286823 - PMCID: PMC3887519
Cheng C, Gao X, Feng B, Sheen J, Shan L, He P
Plant immune response to pathogens differs with changing temperatures.
Nat Commun. 2013;4:2530 - PMID: 24067909 - PMCID: PMC3901997
Li JF, Norville JE, Aach J, McCormack M, Zhang D, Bush J, Church GM, Sheen J
Multiplex and homologous recombination-mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9.
Nat Biotechnol. 2013;31(8):688-91 - PMID: 23929339 - PMCID: PMC4078740
Xiong Y, Sheen J
Moving beyond translation: glucose-TOR signaling in the transcriptional control of cell cycle.
Cell Cycle. 2013;12(13):1989-90 - PMID: 23759578 - PMCID: PMC3737295
Ramon M, Ruelens P, Li Y, Sheen J, Geuten K, Rolland F
The hybrid four-CBS-domain KIN?? subunit functions as the canonical ? subunit of the plant energy sensor SnRK1.
Plant J. 2013;75(1):11-25 - PMID: 23551663