Ruvkun, Gary

Phone: (617) 726-5959


Gary Ruvkun is a professor of genetics at Harvard Medical School. Dr. Ruvkun is a graduate of UC Berkeley (AB, Biophysics,1973) and Harvard (PhD Biophysics, 1982).

Dr. Ruvkun’s honors and awards include the Rosenstiel Award from Brandeis University (with Victor Ambros, Andy Fire, and Craig Mello), the Warren Triennial Prize from Massachusetts General Hospital (with Victor Ambros), the Benjamin Franklin Medal from the Franklin Institute (with Victor Ambros and David Baulcombe), the Gairdner International Award from the Gairdner Foundation of Canada (with Victor Ambros), the Albert Lasker Award for Basic Medical Research (with Victor Ambros and David Baulcombe), the Louisa Horwitz Prize from Columbia University (with Victor Ambros), the Shaul and Meira Massry Prize (with Victor Ambros), the Dan David Prize for Aging research (with Cynthia Kenyon), the Ipsen Foundation Longevity Prize, the Wolf Prize in Medicine (with Victor Ambros and Nahum Sonenberg), the Gruber Genetics Prize (with Victor Ambros), the Breakthrough Prize in Life Sciences (with Victor Ambros), the National Academy of Sciences, the Institute of Medicine, and the American Academy of Arts and Sciences.

Curriculum Vitae

Selected Publications (from total of 181)


Lehrbach NJ, Ruvkun G
Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1.
Elife. 2016;5:ePub - PMID: 27528192 - PMCID: PMC4987142
Dowen RH, Breen PC, Tullius T, Conery AL, Ruvkun G
A microRNA program in the C. elegans hypodermis couples to intestinal mTORC2/PQM-1 signaling to modulate fat transport.
Genes Dev. 2016;30(13):1515-28 - PMID: 27401555 - PMCID: PMC4949325
Samuel BS, Rowedder H, Braendle C, Félix MA, Ruvkun G
Caenorhabditis elegans responses to bacteria from its natural habitats.
Proc Natl Acad Sci U S A. 2016;113(27):E3941-9 - PMID: 27317746 - PMCID: PMC4941482
Rettberg P, Anesio AM, Baker VR, Baross JA, Cady SL, Detsis E, Foreman CM, Hauber E, Ori GG, Pearce DA, Renno NO, Ruvkun G, Sattler B, Saunders MP, Smith DH, Wagner D, Westall F
Planetary Protection and Mars Special Regions-A Suggestion for Updating the Definition.
Astrobiology. 2016;16(2):119-125 - PMID: 26848950
Govindan JA, Jayamani E, Zhang X, Mylonakis E, Ruvkun G
Dialogue between E. coli free radical pathways and the mitochondria of C. elegans.
Proc Natl Acad Sci U S A. 2015;112(40):12456-61 - PMID: 26392561 - PMCID: PMC4603447
Govindan JA, Jayamani E, Zhang X, Breen P, Larkins-Ford J, Mylonakis E, Ruvkun G
Lipid signalling couples translational surveillance to systemic detoxification in Caenorhabditis elegans.
Nat Cell Biol. 2015;17(10):1294-303 - PMID: 26322678 - PMCID: PMC4589496
Phillips CM, Brown KC, Montgomery BE, Ruvkun G, Montgomery TA
piRNAs and piRNA-Dependent siRNAs Protect Conserved and Essential C. elegans Genes from Misrouting into the RNAi Pathway.
Dev Cell. 2015;34(4):457-465 - PMID: 26279487 - PMCID: PMC4550515
Sadreyev IR, Ji F, Cohen E, Ruvkun G, Tabach Y
PhyloGene server for identification and visualization of co-evolving proteins using normalized phylogenetic profiles.
Nucleic Acids Res. 2015;43(W1):W154-W159 - PMID: 25958392 - PMCID: PMC4489270
Kirienko NV, Ausubel FM, Ruvkun G
Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa.
Proc Natl Acad Sci U S A. 2015;112(6):1821-6 - PMID: 25624506 - PMCID: PMC4330731
Wang MC, Oakley HD, Carr CE, Sowa JN, Ruvkun G
Gene Pathways That Delay Caenorhabditis elegans Reproductive Senescence.
PLoS Genet. 2014;10(12):e1004752 - PMID: 25474471 - PMCID: PMC4256158
O'Rourke EJ, Ruvkun G
Corrigendum: MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability.
Nat Cell Biol. 2014;17(1):104 - PMID: 25534088
Govindan JA, Ruvkun G
Virulence. 2014;5(7):ePub - PMID: 25290904 - PMCID: PMC4189874
Govindan JA, Ruvkun G
Virulence. 2014;5(7):695-696 - PMID: 25513769 - PMCID: PMC4189874
Garcia SM, Tabach Y, Lourenço GF, Armakola M, Ruvkun G
Identification of genes in toxicity pathways of trinucleotide-repeat RNA in C. elegans.
Nat Struct Mol Biol. 2014;21(8):712-720 - PMID: 25038802 - PMCID: PMC4125460
Liu Y, Samuel BS, Breen PC, Ruvkun G
Caenorhabditis elegans pathways that surveil and defend mitochondria.
Nature. 2014;508(7496):406-10 - PMID: 24695221 - PMCID: PMC4102179