Xavier, Ramnik

Ramnikxavier1
Phone: 617-643-3331
Email:

Research

Ramnik Xavier is the Kurt Isselbacher Associate Professor of Medicine at Harvard Medical School and the Chief of Gastroenterology at the Massachusetts General Hospital. He is Board Certified in Medicine and Gastroenterology. Ramnik is also the Director of the Center for the Study of Inflammatory Bowel Disease (CSIBD) and a Senior Associate Member of the Broad Institute of MIT and Harvard. Ramnik is clinically active, teaching medical students, residents in medicine, and gastroenterology fellows rotating through the MGH.

Following his clinical training, he completed a postdoctoral fellowship with Professor Brian Seed in the Department of Molecular Biology at MGH and the Department of Genetics at the Harvard Medical School. The overall goal in the laboratory is to discover and understand the function of important mediators and effectors involved in innate (autophagy, pathogen-containing vacuole) and adaptive (T cell activation) immunity. Of particular interest are the cellular components and regulatory networks, which interact dynamically within temporal, spatial and pathophysiological contexts of innate and adaptive immunity. The lab is pursuing integrative systems approaches that closely couple genome-wide experimentation with high-throughput assays and computational methods.

A second area of focus is to examine the pathway defects associated with genetic variants in IBD/T1D and identify novel small molecules that interrupt signal transduction pathways associated with disease risk.

Selected Publications (from total of 162)

Articles

Coffee EM, Faber AC, Roper J, Sinnamon MJ, Goel G, Keung L, Wang WV, Vecchione L, de Vriendt V, Weinstein BJ, Bronson RT, Tejpar S, Xavier RJ, Engelman JA, Martin ES, Hung KE
Concomitant BRAF and PI3K/mTOR Blockade Is Required for Effective Treatment of BRAFV600E Colorectal Cancer.
Clin Cancer Res. 2013;:ePub - PMID: 23549875
Graham DB, Xavier RJ
From genetics of inflammatory bowel disease towards mechanistic insights.
Trends Immunol. 2013;:ePub - PMID: 23639549
Giallourakis CC, Benita Y, Molinie B, Cao Z, Despo O, Pratt HE, Zukerberg LR, Daly MJ, Rioux JD, Xavier RJ
Genome-wide Analysis of Immune System Genes by Expressed Sequence Tag Profiling.
J Immunol. 2013;:ePub - PMID: 23616578
Lupfer C, Thomas PG, Anand PK, Vogel P, Milasta S, Martinez J, Huang G, Green M, Kundu M, Chi H, Xavier RJ, Green DR, Lamkanfi M, Dinarello CA, Doherty PC, Kanneganti TD
Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection.
Nat Immunol. 2013;14(5):480-8 - PMID: 23525089 - PMCID: PMC3631456
Tannahill GM, Curtis AM, Adamik J, Palsson-McDermott EM, McGettrick AF, Goel G, Frezza C, Bernard NJ, Kelly B, Foley NH, Zheng L, Gardet A, Tong Z, Jany SS, Corr SC, Haneklaus M, Caffrey BE, Pierce K, Walmsley S, Beasley FC, Cummins E, Nizet V, Whyte M, Taylor CT, Lin H, Masters SL, Gottlieb E, Kelly VP, Clish C, Auron PE, Xavier RJ, O'Neill LA
Succinate is an inflammatory signal that induces IL-1? through HIF-1?.
Nature. 2013;496(7444):238-42 - PMID: 23535595
Gmyrek GB, Graham DB, Sandoval G, Blaufuss GS, Akilesh HM, Fujikawa K, Xavier RJ, Swat W
Polarity gene discs large homolog 1 regulates the generation of memory T cells.
Eur J Immunol. 2013;43(5):1185-94 - PMID: 23436244
Sandoval GJ, Graham DB, Bhattacharya D, Sleckman BP, Xavier RJ, Swat W
Cutting Edge: cell-autonomous control of IL-7 response revealed in a novel stage of precursor B cells.
J Immunol. 2013;190(6):2485-9 - PMID: 23420891
Conway KL, Kuballa P, Khor B, Zhang M, Shi HN, Virgin HW, Xavier RJ
ATG5 regulates plasma cell differentiation.
Autophagy. 2013;9(4):528-37 - PMID: 23327930
Smeekens SP, Ng A, Kumar V, Johnson MD, Plantinga TS, van Diemen C, Arts P, Verwiel ET, Gresnigt MS, Fransen K, van Sommeren S, Oosting M, Cheng SC, Joosten LA, Hoischen A, Kullberg BJ, Scott WK, Perfect JR, van der Meer JW, Wijmenga C, Netea MG, Xavier RJ
Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans.
Nat Commun. 2013;4:1342 - PMID: 23299892 - PMCID: PMC3625375
Huett A, Heath RJ, Begun J, Sassi SO, Baxt LA, Vyas JM, Goldberg MB, Xavier RJ
The LRR and RING Domain Protein LRSAM1 Is an E3 Ligase Crucial for Ubiquitin-Dependent Autophagy of Intracellular Salmonella Typhimurium.
Cell Host Microbe. 2012;12(6):778-90 - PMID: 23245322
Gardet A, Xavier RJ
Common alleles that influence autophagy and the risk for inflammatory bowel disease.
Curr Opin Immunol. 2012;24(5):522-9 - PMID: 23041451
Kuballa P, Nolte WM, Castoreno AB, Xavier RJ
Autophagy and the immune system.
Annu Rev Immunol. 2012;30:611-46 - PMID: 22449030
Orvedahl A, Sumpter R, Xiao G, Ng A, Zou Z, Tang Y, Narimatsu M, Gilpin C, Sun Q, Roth M, Forst CV, Wrana JL, Zhang YE, Luby-Phelps K, Xavier RJ, Xie Y, Levine B
Image-based genome-wide siRNA screen identifies selective autophagy factors.
Nature. 2011;480(7375):113-7 - PMID: 22020285 - PMCID: PMC3229641
Rivas MA, Beaudoin M, Gardet A, Stevens C, Sharma Y, Zhang CK, Boucher G, Ripke S, Ellinghaus D, Burtt N, Fennell T, Kirby A, Latiano A, Goyette P, Green T, Halfvarson J, Haritunians T, Korn JM, Kuruvilla F, Lagacé C, Neale B, Lo KS, Schumm P, Törkvist L, , , , Dubinsky MC, Brant SR, Silverberg MS, Duerr RH, Altshuler D, Gabriel S, Lettre G, Franke A, D'Amato M, McGovern DP, Cho JH, Rioux JD, Xavier RJ, Daly MJ
Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease.
Nat Genet. 2011;43(11):1066-73 - PMID: 21983784 - PMCID: PMC3378381
Khor B, Gardet A, Xavier RJ
Genetics and pathogenesis of inflammatory bowel disease.
Nature. 2011;474(7351):307-17 - PMID: 21677747 - PMCID: PMC3204665
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