Xavier, Ramnik

Ramnikxavier1
Phone: 617-643-3331
Email:

Research

Ramnik Xavier is the Kurt Isselbacher Professor of Medicine at Harvard Medical School and Chief of Gastroenterology at Massachusetts General Hospital. He is board certified in Medicine and Gastroenterology. Ramnik is also the Director of the Center for the Study of Inflammatory Bowel Disease, an Institute Member of the Broad Institute of MIT and Harvard, and Co-Director of the Center for Microbiome Informatics and Therapeutics at MIT. Ramnik is clinically active, teaching medical students, residents in medicine, and gastroenterology fellows rotating through MGH.

Selected Publications (from total of 275)

Articles

Li Y, Oosting M, Deelen P, Ricaño-Ponce I, Smeekens S, Jaeger M, Matzaraki V, Swertz MA, Xavier RJ, Franke L, Wijmenga C, Joosten LA, Kumar V, Netea MG
Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi.
Nat Med. 2016;:ePub - PMID: 27376574
DeJesus R, Moretti F, McAllister G, Wang Z, Bergman P, Liu S, Frias E, Alford J, Reece-Hoyes JS, Lindeman A, Kelliher J, Russ C, Knehr J, Carbone W, Beibel M, Roma G, Ng A, Tallarico JA, Porter JA, Xavier RJ, Mickanin C, Murphy LO, Hoffman GR, Nyfeler B
Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62.
Elife. 2016;5:ePub - PMID: 27351204 - PMCID: PMC4924995
Xavier RJ
Microbiota as Therapeutic Targets.
Dig Dis. 2016;34(5):558-565 - PMID: 27331403
Zhou C, Elia AE, Naylor ML, Dephoure N, Ballif BA, Goel G, Xu Q, Ng A, Chou DM, Xavier RJ, Gygi SP, Elledge SJ
Profiling DNA damage-induced phosphorylation in budding yeast reveals diverse signaling networks.
Proc Natl Acad Sci U S A. 2016;113(26):E3667-75 - PMID: 27298372 - PMCID: PMC4932963
Boada-Romero E, Serramito-Gómez I, Sacristán MP, Boone DL, Xavier RJ, Pimentel-Muiños FX
The T300A Crohn's disease risk polymorphism impairs function of the WD40 domain of ATG16L1.
Nat Commun. 2016;7:11821 - PMID: 27273576 - PMCID: PMC4899871
Lassen KG, McKenzie CI, Mari M, Murano T, Begun J, Baxt LA, Goel G, Villablanca EJ, Kuo SY, Huang H, Macia L, Bhan AK, Batten M, Daly MJ, Reggiori F, Mackay CR, Xavier RJ
Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk.
Immunity. 2016;44(6):1392-1405 - PMID: 27287411 - PMCID: PMC4936415
Vatanen T, Kostic AD, d'Hennezel E, Siljander H, Franzosa EA, Yassour M, Kolde R, Vlamakis H, Arthur TD, Hämäläinen AM, Peet A, Tillmann V, Uibo R, Mokurov S, Dorshakova N, Ilonen J, Virtanen SM, Szabo SJ, Porter JA, Lähdesmäki H, Huttenhower C, Gevers D, Cullen TW, Knip M, , Xavier RJ
Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans.
Cell. 2016;165(6):1551 - PMID: 27259157
Yassour M, Vatanen T, Siljander H, Hämäläinen AM, Härkönen T, Ryhänen SJ, Franzosa EA, Vlamakis H, Huttenhower C, Gevers D, Lander ES, Knip M, , Xavier RJ
Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability.
Sci Transl Med. 2016;8(343):343ra81 - PMID: 27306663
Sundberg TB, Liang Y, Wu H, Choi HG, Kim ND, Sim T, Johannessen L, Petrone A, Khor B, Graham DB, Latorre IJ, Phillips AJ, Schreiber SL, Perez J, Shamji AF, Gray NS, Xavier RJ
Development of Chemical Probes for Investigation of Salt-Inducible Kinase Function In Vivo.
ACS Chem Biol. 2016;:ePub - PMID: 27224444
O'Connell DJ, Kolde R, Sooknah M, Graham DB, Sundberg TB, Latorre IJ, Mikkelsen TS, Xavier RJ
Simultaneous Pathway Activity Inference and Gene Expression Analysis Using RNA Sequencing.
Cell Syst. 2016;2(5):323-334 - PMID: 27211859
Lamas B, Richard ML, Leducq V, Pham HP, Michel ML, Da Costa G, Bridonneau C, Jegou S, Hoffmann TW, Natividad JM, Brot L, Taleb S, Couturier-Maillard A, Nion-Larmurier I, Merabtene F, Seksik P, Bourrier A, Cosnes J, Ryffel B, Beaugerie L, Launay JM, Langella P, Xavier RJ, Sokol H
CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands.
Nat Med. 2016;22(6):598-605 - PMID: 27158904
Chu H, Khosravi A, Kusumawardhani IP, Kwon AH, Vasconcelos AC, Cunha LD, Mayer AE, Shen Y, Wu WL, Kambal A, Targan SR, Xavier RJ, Ernst PB, Green DR, McGovern DP, Virgin HW, Mazmanian SK
Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease.
Science. 2016;352(6289):1116-20 - PMID: 27230380
Taleban S, Stewart KO, Li DK, Singh P, Pardi DS, Sturgeon HC, Yajnik V, Xavier RJ, Ananthakrishnan AN, Khalili H
Clinical Activity and Quality of Life Indices Are Valid Across Ulcerative Colitis But Not Crohn's Disease Phenotypes.
Dig Dis Sci. 2016;:ePub - PMID: 27142671
Peloquin JM, Goel G, Villablanca EJ, Xavier RJ
Mechanisms of Pediatric Inflammatory Bowel Disease.
Annu Rev Immunol. 2016;34:31-64 - PMID: 27168239
Zhernakova A, Kurilshikov A, Bonder MJ, Tigchelaar EF, Schirmer M, Vatanen T, Mujagic Z, Vila AV, Falony G, Vieira-Silva S, Wang J, Imhann F, Brandsma E, Jankipersadsing SA, Joossens M, Cenit MC, Deelen P, Swertz MA, , Weersma RK, Feskens EJ, Netea MG, Gevers D, Jonkers D, Franke L, Aulchenko YS, Huttenhower C, Raes J, Hofker MH, Xavier RJ, Wijmenga C, Fu J
Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity.
Science. 2016;352(6285):565-9 - PMID: 27126040
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