Xavier, Ramnik

Ramnikxavier1
Phone: 617-643-3331
Email:

Research

Ramnik Xavier is the Kurt Isselbacher Professor of Medicine at Harvard Medical School and the Chief of Gastroenterology at the Massachusetts General Hospital. He is Board Certified in Medicine and Gastroenterology. Ramnik is also the Director of the Center for the Study of Inflammatory Bowel Disease (CSIBD) and a Senior Associate Member of the Broad Institute of MIT and Harvard. Ramnik is clinically active, teaching medical students, residents in medicine, and gastroenterology fellows rotating through the MGH.

Following his clinical training, he completed a postdoctoral fellowship with Professor Brian Seed in the Department of Molecular Biology at MGH and the Department of Genetics at the Harvard Medical School. The overall goal in the laboratory is to discover and understand the function of important mediators and effectors involved in innate (autophagy, pathogen-containing vacuole) and adaptive (T cell activation) immunity. Of particular interest are the cellular components and regulatory networks, which interact dynamically within temporal, spatial and pathophysiological contexts of innate and adaptive immunity. The lab is pursuing integrative systems approaches that closely couple genome-wide experimentation with high-throughput assays and computational methods.

A second area of focus is to examine the pathway defects associated with genetic variants in IBD/T1D and identify novel small molecules that interrupt signal transduction pathways associated with disease risk.

Selected Publications (from total of 224)

Articles

Guo AY, Stevens BW, Wilson RG, Russell CN, Cohen MA, Sturgeon HC, Thornton A, Giallourakis C, Khalili H, Nguyen DD, Sauk J, Yajnik V, Xavier RJ, Ananthakrishnan AN
Early life environment and natural history of inflammatory bowel diseases.
BMC Gastroenterol. 2014;14(1):216 - PMID: 25510175
Paulus GL, Xavier RJ
Autophagy and checkpoints for intracellular pathogen defense.
Curr Opin Gastroenterol. 2014;31(1):14-23 - PMID: 25394238
Buffen K, Oosting M, Quintin J, Ng A, Kleinnijenhuis J, Kumar V, van de Vosse E, Wijmenga C, van Crevel R, Oosterwijk E, Grotenhuis AJ, Vermeulen SH, Kiemeney LA, van de Veerdonk FL, Chamilos G, Xavier RJ, van der Meer JW, Netea MG, Joosten LA
Autophagy Controls BCG-Induced Trained Immunity and the Response to Intravesical BCG Therapy for Bladder Cancer.
PLoS Pathog. 2014;10(10):e1004485 - PMID: 25356988 - PMCID: PMC4214925
Kleinnijenhuis J, Quintin J, Preijers F, Joosten LA, Jacobs C, Xavier RJ, van der Meer JW, van Crevel R, Netea MG
BCG-induced trained immunity in NK cells: Role for non-specific protection to infection.
Clin Immunol. 2014;155(2):213-219 - PMID: 25451159
Kumar V, Wijmenga C, Xavier RJ
Genetics of immune-mediated disorders: from genome-wide association to molecular mechanism.
Curr Opin Immunol. 2014;31C:51-57 - PMID: 25458995
Liao J, Jijon HB, Kim IR, Goel G, Doan A, Sokol H, Bauer H, Herrmann BG, Lassen KG, Xavier RJ
An Image-Based Genetic Assay Identifies Genes in T1D Susceptibility Loci Controlling Cellular Antiviral Immunity in Mouse.
PLoS One. 2014;9(9):e108777 - PMID: 25268627 - PMCID: PMC4182575
Platt RJ, Chen S, Zhou Y, Yim MJ, Swiech L, Kempton HR, Dahlman JE, Parnas O, Eisenhaure TM, Jovanovic M, Graham DB, Jhunjhunwala S, Heidenreich M, Xavier RJ, Langer R, Anderson DG, Hacohen N, Regev A, Feng G, Sharp PA, Zhang F
CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling.
Cell. 2014;159(2):440-55 - PMID: 25263330 - PMCID: PMC4265475
Draberova L, Bugajev V, Potuckova L, Halova I, Bambouskova M, Polakovicova I, Xavier RJ, Seed B, Draber P
Transmembrane adaptor protein PAG/CBP is involved in both positive and negative regulation of mast cell signaling.
Mol Cell Biol. 2014;34(23):4285-300 - PMID: 25246632 - PMCID: PMC4248753
Sundberg TB, Xavier RJ, Schreiber SL, Shamji AF
Small-molecule control of cytokine function: new opportunities for treating immune disorders.
Curr Opin Chem Biol. 2014;23C:23-30 - PMID: 25222143
Kumar V, Cheng SC, Johnson MD, Smeekens SP, Wojtowicz A, Giamarellos-Bourboulis E, Karjalainen J, Franke L, Withoff S, Plantinga TS, van de Veerdonk FL, van der Meer JW, Joosten LA, Sokol H, Bauer H, Herrmann BG, Bochud PY, Marchetti O, Perfect JR, Xavier RJ, Kullberg BJ, Wijmenga C, Netea MG
Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidaemia.
Nat Commun. 2014;5:4675 - PMID: 25197941
Doench JG, Hartenian E, Graham DB, Tothova Z, Hegde M, Smith I, Sullender M, Ebert BL, Xavier RJ, Root DE
Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation.
Nat Biotechnol. 2014;32(12):1262-1267 - PMID: 25184501 - PMCID: PMC4262738
Saeed S, Quintin J, Kerstens HH, Rao NA, Aghajanirefah A, Matarese F, Cheng SC, Ratter J, Berentsen K, van der Ent MA, Sharifi N, Janssen-Megens EM, Ter Huurne M, Mandoli A, van Schaik T, Ng A, Burden F, Downes K, Frontini M, Kumar V, Giamarellos-Bourboulis EJ, Ouwehand WH, van der Meer JW, Joosten LA, Wijmenga C, Martens JH, Xavier RJ, Logie C, Netea MG, Stunnenberg HG
Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity.
Science. 2014;345(6204):1251086 - PMID: 25258085 - PMCID: PMC4242194
Cheng SC, Quintin J, Cramer RA, Shepardson KM, Saeed S, Kumar V, Giamarellos-Bourboulis EJ, Martens JH, Rao NA, Aghajanirefah A, Manjeri GR, Li Y, Ifrim DC, Arts RJ, van der Meer BM, Deen PM, Logie C, O'Neill LA, Willems P, van de Veerdonk FL, van der Meer JW, Ng A, Joosten LA, Wijmenga C, Stunnenberg HG, Xavier RJ, Netea MG
mTOR- and HIF-1?-mediated aerobic glycolysis as metabolic basis for trained immunity.
Science. 2014;345(6204):1250684 - PMID: 25258083 - PMCID: PMC4226238
Goel G, Conway KL, Jaeger M, Netea MG, Xavier RJ
Multivariate inference of pathway activity in host immunity and response to therapeutics.
Nucleic Acids Res. 2014;42(16):10288-306 - PMID: 25147207 - PMCID: PMC4176341
Lassen KG, Xavier RJ
An alteration in ATG16L1 stability in Crohn disease.
Autophagy. 2014;10(10):1858-1860 - PMID: 25136803 - PMCID: PMC4198368
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