Publications - Szostak
Fang Z, Pazienza LT, Zhang J, Tam CP, Szostak JW Catalytic Metal Ion-Substrate Coordination during Nonenzymatic RNA Primer Extension. J Am Chem Soc. 2024;146(15):10632-10639 - PMID: 38579124 - PMCID: PMC11027144 - DOI: 10.1021/jacs.4c00323
Radakovic A, Lewicka A, Todisco M, Aitken HRM, Weiss Z, Kim S, Bannan A, Piccirilli JA, Szostak JW Structure-guided aminoacylation and assembly of chimeric RNAs. bioRxiv. 2024;:ePub - PMID: 38464152 - PMCID: PMC10925264 - DOI: 10.1101/2024.03.02.583109
Todisco M, Ding D, Szostak JW Transient states during the annealing of mismatched and bulged oligonucleotides. Nucleic Acids Res. 2024;52(5):2174-2187 - PMID: 38348869 - PMCID: PMC10954449 - DOI: 10.1093/nar/gkae091
Ding D, Fang Z, Kim SC, O'Flaherty DK, Jia X, Stone TB, Zhou L, Szostak JW Unusual Base Pair between Two 2-Thiouridines and Its Implication for Nonenzymatic RNA Copying. J Am Chem Soc. 2024;146(6):3861-3871 - PMID: 38293747 - PMCID: PMC10870715 - DOI: 10.1021/jacs.3c11158
Lelyveld VS, Fang Z, Szostak JW Trivalent rare earth metal cofactors confer rapid NP-DNA polymerase activity. Science. 2023;382(6669):423-429 - PMID: 37883544 - PMCID: PMC10886449 - DOI: 10.1126/science.adh5339
DasGupta S, Zhang S, Szostak JW Molecular Crowding Facilitates Ribozyme-Catalyzed RNA Assembly. ACS Cent Sci. 2023;9(8):1670-1678 - PMID: 37637737 - PMCID: PMC10451029 - DOI: 10.1021/acscentsci.3c00547
Ashwood B, Jones MS, Radakovic A, Khanna S, Lee Y, Sachleben JR, Szostak JW, Ferguson AL, Tokmakoff A Thermodynamics and kinetics of DNA and RNA dinucleotide hybridization to gaps and overhangs. Biophys J. 2023;122(16):3323-3339 - PMID: 37469144 - PMCID: PMC10465710 - DOI: 10.1016/j.bpj.2023.07.009
Aitken HRM, Wright TH, Radakovic A, Szostak JW Small-Molecule Organocatalysis Facilitates In Situ Nucleotide Activation and RNA Copying. J Am Chem Soc. 2023;145(29):16142-16149 - PMID: 37431761 - PMCID: PMC10375519 - DOI: 10.1021/jacs.3c04635
Zhang SJ, Lowe LA, Anees P, Krishnan Y, Fai TG, Szostak JW, Wang A Passive endocytosis in model protocells. Proc Natl Acad Sci U S A. 2023;120(24):e2221064120 - PMID: 37276401 - PMCID: PMC10268330 - DOI: 10.1073/pnas.2221064120
Ding D, Zhang SJ, Szostak JW Enhanced nonenzymatic RNA copying with in-situ activation of short oligonucleotides. Nucleic Acids Res. 2023;51(13):6528-6539 - PMID: 37247941 - PMCID: PMC10359593 - DOI: 10.1093/nar/gkad439
Fan Z, Deckel Y, Lowe LA, Loo DWK, Yomo T, Szostak JW, Nisler C, Wang A Lipid Exchange Promotes Fusion of Model Protocells. Small Methods. 2023;7(12):e2300126 - PMID: 37246261 - DOI: 10.1002/smtd.202300126
DasGupta S, Zhang SJ, Smela MP, Szostak JW RNA-catalyzed RNA Ligation within Prebiotically Plausible Model Protocells. Chemistry. 2023;29(43):e202301376 - PMID: 37216492 - DOI: 10.1002/chem.202301376
Zhang SJ, Lowe LA, Anees P, Krishnan Y, Fai TG, Szostak JW, Wang A Passive endocytosis in model protocells. bioRxiv. 2023;:ePub - PMID: 37205531 - PMCID: PMC10187163 - DOI: 10.1101/2023.01.07.522792
Ding D, Zhou L, Mittal S, Szostak JW Experimental Tests of the Virtual Circular Genome Model for Nonenzymatic RNA Replication. J Am Chem Soc. 2023;145(13):7504-7515 - PMID: 36963403 - PMCID: PMC10080680 - DOI: 10.1021/jacs.3c00612
Strom KR, Szostak JW Folding and Duplex Formation in Sequence-Defined Aniline Benzaldehyde Oligoarylacetylenes. J Am Chem Soc. 2022;144(40):18350-18358 - PMID: 36174969 - PMCID: PMC9562438 - DOI: 10.1021/jacs.2c06268
Todisco M, Szostak JW Hybridization kinetics of out-of-equilibrium mixtures of short RNA oligonucleotides. Nucleic Acids Res. 2022;50(17):9647-9662 - PMID: 36099434 - PMCID: PMC9508827 - DOI: 10.1093/nar/gkac784
Wu LF, Liu Z, Roberts SJ, Su M, Szostak JW, Sutherland JD Template-Free Assembly of Functional RNAs by Loop-Closing Ligation. J Am Chem Soc. 2022;144(30):13920-13927 - PMID: 35880790 - PMCID: PMC9354263 - DOI: 10.1021/jacs.2c05601
Zhang SJ, Duzdevich D, Ding D, Szostak JW Freeze-thaw cycles enable a prebiotically plausible and continuous pathway from nucleotide activation to nonenzymatic RNA copying. Proc Natl Acad Sci U S A. 2022;119(17):e2116429119 - PMID: 35446612 - PMCID: PMC9169909 - DOI: 10.1073/pnas.2116429119
Radakovic A, DasGupta S, Wright TH, Aitken HRM, Szostak JW Nonenzymatic assembly of active chimeric ribozymes from aminoacylated RNA oligonucleotides. Proc Natl Acad Sci U S A. 2022;119(7):ePub - PMID: 35140183 - PMCID: PMC8851484 - DOI: 10.1073/pnas.2116840119
Ding D, Zhou L, Giurgiu C, Szostak JW Kinetic explanations for the sequence biases observed in the nonenzymatic copying of RNA templates. Nucleic Acids Res. 2022;50(1):35-45 - PMID: 34893864 - PMCID: PMC8754633 - DOI: 10.1093/nar/gkab1202
Duzdevich D, Carr CE, Ding D, Zhang SJ, Walton TS, Szostak JW Competition between bridged dinucleotides and activated mononucleotides determines the error frequency of nonenzymatic RNA primer extension. Nucleic Acids Res. 2021;49(7):3681-3691 - PMID: 33744957 - PMCID: PMC8053118 - DOI: 10.1093/nar/gkab173
Kim SC, O'Flaherty DK, Giurgiu C, Zhou L, Szostak JW The Emergence of RNA from the Heterogeneous Products of Prebiotic Nucleotide Synthesis. J Am Chem Soc. 2021;143(9):3267-3279 - PMID: 33636080 - DOI: 10.1021/jacs.0c12955
Mojarro A, Jin L, Szostak JW, Head JW, Zuber MT In search of the RNA world on Mars. Geobiology. 2021;19(3):307-321 - PMID: 33565260 - PMCID: PMC8248371 - DOI: 10.1111/gbi.12433
Radakovic A, Wright TH, Lelyveld VS, Szostak JW A Potential Role for Aminoacylation in Primordial RNA Copying Chemistry. Biochemistry. 2021;60(6):477-488 - PMID: 33523633 - PMCID: PMC9634692 - DOI: 10.1021/acs.biochem.0c00943
Todd ZR, Szostak JW, Sasselov DD Shielding from UV Photodamage: Implications for Surficial Origins of Life Chemistry on the Early Earth. ACS Earth Space Chem. 2021;5(2):239-246 - PMID: 36317066 - PMCID: PMC9616438 - DOI: 10.1021/acsearthspacechem.0c00270
Zhang W, Kim SC, Tam CP, Lelyveld VS, Bala S, Chaput JC, Szostak JW Structural interpretation of the effects of threo-nucleotides on nonenzymatic template-directed polymerization. Nucleic Acids Res. 2021;49(2):646-656 - PMID: 33347562 - PMCID: PMC7826252 - DOI: 10.1093/nar/gkaa1215
Strom KR, Szostak JW Solid-Phase Synthesis of Sequence-Defined Informational Oligomers. J Org Chem. 2020;85(21):13929-13938 - PMID: 33064001 - PMCID: PMC9594334 - DOI: 10.1021/acs.joc.0c01977
Zhou L, Ding D, Szostak JW The Virtual Circular Genome Model for Primordial RNA Replication. RNA. 2021;27(1):1-11 - PMID: 33028653 - PMCID: PMC7749632 - DOI: 10.1261/rna.077693.120
O'Flaherty DK, Zhou L, Szostak JW Nonenzymatic RNA-templated Synthesis of N3'→P5' Phosphoramidate DNA. Bio Protoc. 2020;10(17):e3734 - PMID: 33659395 - PMCID: PMC7842504 - DOI: 10.21769/BioProtoc.3734
Zhang SJ, Duzdevich D, Szostak JW Potentially Prebiotic Activation Chemistry Compatible with Nonenzymatic RNA Copying. J Am Chem Soc. 2020;142(35):14810-14813 - PMID: 32794700 - PMCID: PMC9594304 - DOI: 10.1021/jacs.0c05300
Zhou L, O'Flaherty DK, Szostak JW Assembly of a ribozyme ligase from short oligomers by nonenzymatic ligation. J Am Chem Soc. 2020;142(37):15961-15965 - PMID: 32820909 - PMCID: PMC9594310 - DOI: 10.1021/jacs.0c06722
Zhou L, O'Flaherty DK, Szostak JW Template-directed copying of RNA by non-enzymatic ligation. Angew Chem Int Ed Engl. 2020;59(36):15682-15687 - PMID: 32558121 - PMCID: PMC7496532 - DOI: 10.1002/anie.202004934
Kindt JT, Szostak JW, Wang A Bulk Self-Assembly of Giant, Unilamellar Vesicles. ACS Nano. 2020;14(11):14627-14634 - PMID: 32602696 - PMCID: PMC8172239 - DOI: 10.1021/acsnano.0c03125
Duzdevich D, Carr CE, Szostak JW Deep sequencing of non-enzymatic RNA primer extension. Nucleic Acids Res. 2020;48(12):e70 - PMID: 32427335 - PMCID: PMC7337528 - DOI: 10.1093/nar/gkaa400
Todd ZR, Fahrenbach AC, Ranjan S, Magnani CJ, Szostak JW, Sasselov DD Ultraviolet-Driven Deamination of Cytidine Ribonucleotides Under Planetary Conditions. Astrobiology. 2020;20(7):878-888 - PMID: 32267736 - PMCID: PMC9634989 - DOI: 10.1089/ast.2019.2182
Lelyveld VS, Zhang W, Szostak JW Synthesis of phosphoramidate-linked DNA by a modified DNA polymerase. Proc Natl Acad Sci U S A. 2020;117(13):7276-7283 - PMID: 32188786 - PMCID: PMC7132125 - DOI: 10.1073/pnas.1922400117
Walton T, DasGupta S, Duzdevich D, Oh SS, Szostak JW In vitro selection of ribozyme ligases that use prebiotically plausible 2-aminoimidazole-activated substrates. Proc Natl Acad Sci U S A. 2020;117(11):5741-5748 - PMID: 32123094 - PMCID: PMC7084097 - DOI: 10.1073/pnas.1914367117
Kim SC, Zhou L, Zhang W, O'Flaherty DK, Rondo-Brovetto V, Szostak JW A model for the emergence of RNA from a prebiotically plausible mixture of ribonucleotides, arabinonucleotides and 2'-deoxynucleotides. J Am Chem Soc. 2020;142(5):2317-2326 - PMID: 31913615 - PMCID: PMC7577264 - DOI: 10.1021/jacs.9b11239
Zhou L, Kim S, Ho KH, O'Flaherty DK, Giurgiu C, Wright TH, Szostak JW Non-enzymatic primer extension with strand displacement. Elife. 2019;8:ePub - PMID: 31702557 - PMCID: PMC6872209 - DOI: 10.7554/eLife.51888
Wang A, Szostak JW Lipid constituents of model protocell membranes. Emerg Top Life Sci. 2019;3(5):537-542 - PMID: 33523161 - DOI: 10.1042/ETLS20190021
Wright TH, Giurgiu C, Zhang W, Radakovic A, O'Flaherty DK, Zhou L, Szostak JW Prebiotically Plausible 'Patching' of RNA Backbone Cleavage Through a 3'-5' Pyrophosphate Linkage. J Am Chem Soc. 2019;141(45):18104-18112 - PMID: 31651170 - PMCID: PMC7577263 - DOI: 10.1021/jacs.9b08237
Lelyveld VS, O'Flaherty DK, Zhou L, Izgu EC, Szostak JW DNA polymerase activity on synthetic N3'→P5' phosphoramidate DNA templates. Nucleic Acids Res. 2019;47(17):8941-8949 - PMID: 31428779 - PMCID: PMC6755091 - DOI: 10.1093/nar/gkz707
Todd ZR, Szabla R, Szostak JW, Sasselov DD UV photostability of three 2-aminoazoles with key roles in prebiotic chemistry on the early earth. Chem Commun (Camb). 2019;55(70):10388-10391 - PMID: 31380533 - PMCID: PMC9631353 - DOI: 10.1039/c9cc05265h
Zhang W, Pal A, Ricardo A, Szostak JW Template-directed Nonenzymatic Primer Extension Using 2-methylimidazole-activated Morpholino Derivatives of Guanosine and Cytidine. J Am Chem Soc. 2019;141(30):12159-12166 - PMID: 31298852 - PMCID: PMC7547883 - DOI: 10.1021/jacs.9b06453
O'Flaherty DK, Zhou L, Szostak JW Nonenzymatic template-directed synthesis of mixed-sequence 3'-NP-DNA up to 25 nucleotides long inside model protocells. J Am Chem Soc. 2019;141(26):10481-10488 - PMID: 31180644 - PMCID: PMC7547854 - DOI: 10.1021/jacs.9b04858
Walton T, Zhang W, Li L, Tam CP, Szostak JW The mechanism of nonenzymatic template copying with imidazole-activated nucleotides. Angew Chem Int Ed Engl. 2019;58(32):10812-10819 - PMID: 30908802 - DOI: 10.1002/anie.201902050
Strom KR, Szostak JW, Prywes N Transfer of Sequence Information and Replication of Diimine Duplexes. J Org Chem. 2019;84(7):3754-3761 - PMID: 30855962 - PMCID: PMC7547894 - DOI: 10.1021/acs.joc.9b00095
Matsushita-Ishiodori Y, Hanczyc MM, Wang A, Szostak JW, Yomo T Using Imaging Flow Cytometry to Quantify and Optimize Giant Vesicle Production by Water-in-oil Emulsion Transfer Methods. Langmuir. 2019;35(6):2375-2382 - PMID: 30645943 - DOI: 10.1021/acs.langmuir.8b03635
Wang A, Chan Miller C, Szostak JW Core-Shell Modeling of Light Scattering by Vesicles: Effect of Size, Contents, and Lamellarity. Biophys J. 2019;116(4):659-669 - PMID: 30686489 - PMCID: PMC6382849 - DOI: 10.1016/j.bpj.2019.01.006
Kim SC, O'Flaherty DK, Zhou L, Lelyveld VS, Szostak JW Inosine, but none of the 8-oxo-purines, is a plausible component of a primordial version of RNA. Proc Natl Acad Sci U S A. 2018;115(52):13318-13323 - PMID: 30509978 - PMCID: PMC6310819 - DOI: 10.1073/pnas.1814367115
Jin L, Engelhart AE, Zhang W, Adamala KP, Szostak JW Catalysis of Template-directed Nonenzymatic RNA Copying by Iron (II). J Am Chem Soc. 2018;140(44):15016-15021 - PMID: 30335371 - PMCID: PMC7547886 - DOI: 10.1021/jacs.8b09617
Joyce GF, Szostak JW Protocells and RNA Self-Replication. Cold Spring Harb Perspect Biol. 2018;10(9):ePub - PMID: 30181195 - PMCID: PMC6120706 - DOI: 10.1101/cshperspect.a034801
Zhang W, Walton T, Li L, Szostak JW Crystallographic observation of nonenzymatic RNA primer extension. Elife. 2018;7:ePub - PMID: 29851379 - PMCID: PMC5980232 - DOI: 10.7554/eLife.36422
O'Flaherty DK, Kamat NP, Mirza FN, Li L, Prywes N, Szostak JW Copying of mixed sequence RNA templates inside model protocells. J Am Chem Soc. 2018;140(15):5171-5178 - PMID: 29608310 - PMCID: PMC7547884 - DOI: 10.1021/jacs.8b00639
Jin L, Kamat NP, Jena S, Szostak JW Fatty Acid/Phospholipid Blended Membranes: A Potential Intermediate State in Protocellular Evolution. Small. 2018;14(15):e1704077 - PMID: 29479815 - PMCID: PMC6278924 - DOI: 10.1002/smll.201704077
Jin L, Engelhart AE, Adamala KP, Szostak JW Preparation, Purification, and Use of Fatty Acid-containing Liposomes. J Vis Exp. 2018;(132):ePub - PMID: 29553563 - PMCID: PMC5912384 - DOI: 10.3791/57324
Zhang W, Tam CP, Zhou L, Oh SS, Wang J, Szostak JW A structural rationale for the enhanced catalysis of nonenzymatic RNA primer extension by a downstream oligonucleotide. J Am Chem Soc. 2018;140(8):2829-2840 - PMID: 29411978 - PMCID: PMC6326529 - DOI: 10.1021/jacs.7b11750
Todd ZR, Fahrenbach AC, Magnani CJ, Ranjan S, Björkbom A, Szostak JW, Sasselov DD Solvated-electron production using cyanocuprates is compatible with the UV-environment on a Hadean-Archaean Earth. Chem Commun (Camb). 2018;54(9):1121-1124 - PMID: 29334083 - PMCID: PMC9631354 - DOI: 10.1039/c7cc07748c
Giurgiu C, Li L, O'Flaherty DK, Tam CP, Szostak JW A Mechanistic Explanation for the Regioselectivity of Nonenzymatic RNA Primer Extension. J Am Chem Soc. 2017;139(46):16741-16747 - PMID: 29112424 - PMCID: PMC6326530 - DOI: 10.1021/jacs.7b08784
Jia TZ, Fahrenbach AC, Kamat NP, Adamala KP, Szostak JW Retraction: Oligoarginine peptides slow strand annealing and assist non-enzymatic RNA replication. Nat Chem. 2017;9(12):1286 - PMID: 29168488 - PMCID: PMC7412977 - DOI: 10.1038/nchem.2885
Walton T, Szostak JW A kinetic model of nonenzymatic RNA polymerization by cytidine-5'-phosphoro-2-aminoimidazolide. Biochemistry. 2017;56(43):5739-5747 - PMID: 29022704 - PMCID: PMC6340129 - DOI: 10.1021/acs.biochem.7b00792
Bonfio C, Valer L, Scintilla S, Shah S, Evans DJ, Jin L, Szostak JW, Sasselov DD, Sutherland JD, Mansy SS UV-light-driven prebiotic synthesis of iron-sulfur clusters. Nat Chem. 2017;9(12):1229-1234 - PMID: 29168482 - PMCID: PMC5808832 - DOI: 10.1038/nchem.2817
Zhang W, Tam CP, Walton T, Fahrenbach AC, Birrane G, Szostak JW Insight into the mechanism of nonenzymatic RNA primer extension from the structure of an RNA-GpppG complex. Proc Natl Acad Sci U S A. 2017;114(29):7659-7664 - PMID: 28673998 - PMCID: PMC5530681 - DOI: 10.1073/pnas.1704006114
Fahrenbach AC, Giurgiu C, Tam CP, Li L, Hongo Y, Aono M, Szostak JW Common and Potentially Prebiotic Origin for Precursors of Nucleotide Synthesis and Activation. J Am Chem Soc. 2017;139(26):8780-8783 - PMID: 28640999 - PMCID: PMC6326526 - DOI: 10.1021/jacs.7b01562
Stairs S, Nikmal A, Bucar DK, Zheng SL, Szostak JW, Powner MW Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides. Nat Commun. 2017;8:15270 - PMID: 28524845 - PMCID: PMC5454461 - DOI: 10.1038/ncomms15270
Szostak JW The Narrow Road to the Deep Past. Angew Chem Int Ed Engl. 2017;56(37):11037-11043 - PMID: 28514493 - DOI: 10.1002/anie.201704048
Li L, Prywes N, Tam CP, O'Flaherty DK, Lelyveld VS, Izgu EC, Pal A, Szostak JW Enhanced Nonenzymatic RNA Copying with 2-Aminoimidazole Activated Nucleotides. J Am Chem Soc. 2017;139(5):1810-1813 - PMID: 28117989 - PMCID: PMC6326525 - DOI: 10.1021/jacs.6b13148
Tam CP, Fahrenbach AC, Björkbom A, Prywes N, Izgu EC, Szostak JW Downstream Oligonucleotides Strongly Enhance the Affinity of GMP to RNA Primer-Template Complexes. J Am Chem Soc. 2017;139(2):571-574 - PMID: 28055190 - PMCID: PMC7547879 - DOI: 10.1021/jacs.6b09760
Izgu EC, Björkbom A, Kamat NP, Lelyveld VS, Zhang W, Jia TZ, Szostak JW N-Carboxyanhydride-Mediated Fatty Acylation of Amino Acids and Peptides for Functionalization of Protocell Membranes. J Am Chem Soc. 2016;138(51):16669-16676 - PMID: 27959544 - PMCID: PMC7547885 - DOI: 10.1021/jacs.6b08801
Zhang W, Tam CP, Wang J, Szostak JW Unusual Base-Pairing Interactions in Monomer-Template Complexes. ACS Cent Sci. 2016;2(12):916-926 - PMID: 28058281 - PMCID: PMC5200924 - DOI: 10.1021/acscentsci.6b00278
Pal A, Das RS, Zhang W, Lang M, McLaughlin LW, Szostak JW Effect of terminal 3'-hydroxymethyl modification of an RNA primer on nonenzymatic primer extension. Chem Commun (Camb). 2016;52(80):11905-11907 - PMID: 27722518 - DOI: 10.1039/c6cc06925h
Szostak JW On the origin of life. Medicina (B Aires). 2016;76(4):199-203 - PMID: 27576276
Walton T, Szostak JW A highly reactive imidazolium-bridged dinucleotide intermediate in nonenzymatic RNA primer extension. J Am Chem Soc. 2016;138(36):11996-2002 - PMID: 27552367 - PMCID: PMC6326528 - DOI: 10.1021/jacs.6b07977
Prywes N, Blain JC, Del Frate F, Szostak JW Nonenzymatic copying of RNA templates containing all four letters is catalyzed by activated oligonucleotides. Elife. 2016;5:ePub - PMID: 27351102 - PMCID: PMC4959843 - DOI: 10.7554/eLife.17756
Jia TZ, Fahrenbach AC, Kamat NP, Adamala KP, Szostak JW Oligoarginine peptides slow strand annealing and assist non-enzymatic RNA replication. Nat Chem. 2016;8(10):915-21 - PMID: 27657866 - PMCID: PMC5061144 - DOI: 10.1038/nchem.2551
Prywes N, Michaels YS, Pal A, Oh SS, Szostak JW Thiolated uridine substrates and templates improve the rate and fidelity of ribozyme-catalyzed RNA copying. Chem Commun (Camb). 2016;52(39):6529-32 - PMID: 27109314 - DOI: 10.1039/c6cc02692c
Adamala KP, Engelhart AE, Szostak JW Collaboration between primitive cell membranes and soluble catalysts. Nat Commun. 2016;7:11041 - PMID: 26996603 - PMCID: PMC4802160 - DOI: 10.1038/ncomms11041
Li L, Lelyveld VS, Prywes N, Szostak JW Experimental and computational evidence for a loose transition state in phosphoroimidazolide hydrolysis. J Am Chem Soc. 2016;138(12):3986-9 - PMID: 26974265 - PMCID: PMC7547882 - DOI: 10.1021/jacs.6b00784
Engelhart AE, Adamala KP, Szostak JW A simple physical mechanism enables homeostasis in primitive cells. Nat Chem. 2016;8(5):448-53 - PMID: 27102678 - PMCID: PMC4929987 - DOI: 10.1038/nchem.2475
Izgu EC, Oh SS, Szostak JW Synthesis of activated 3'-amino-3'-deoxy-2-thio-thymidine, a superior substrate for the nonenzymatic copying of nucleic acid templates. Chem Commun (Camb). 2016;52(18):3684-6 - PMID: 26857159 - DOI: 10.1039/c5cc10317g
Lelyveld VS, Bjorkbom A, Ransey E, Sliz P, Szostak JW Pinpointing RNA-protein crosslinks with site-specific stable isotope labeled oligonucleotides. J Am Chem Soc. 2015;137(49):15378-15381 - PMID: 26583201 - PMCID: PMC4697197 - DOI: 10.1021/jacs.5b10596
Bjorkbom A, Lelyveld VS, Zhang S, Zhang W, Tam CP, Blain JC, Szostak JW Bidirectional direct sequencing of non-canonical RNA by two-dimensional analysis of mass chromatograms. J Am Chem Soc. 2015;137(45):14430-8 - PMID: 26495937 - PMCID: PMC7547889 - DOI: 10.1021/jacs.5b09438
Larsen AT, Fahrenbach AC, Sheng J, Pian J, Szostak JW Thermodynamic insights into 2-thiouridine-enhanced RNA hybridization. Nucleic Acids Res. 2015;43(16):7675-87 - PMID: 26240387 - PMCID: PMC4652770 - DOI: 10.1093/nar/gkv761
Kamat NP, Tobé S, Hill IT, Szostak JW Electrostatic Localization of RNA to Protocell Membranes by Cationic Hydrophobic Peptides. Angew Chem Int Ed Engl. 2015;54(40):11735-11739 - PMID: 26223820 - PMCID: PMC4600236 - DOI: 10.1002/anie.201505742
Adamala K, Engelhart AE, Kamat NP, Jin L, Szostak JW Construction of a liposome dialyzer for the preparation of high-value, small-volume liposome formulations. Nat Protoc. 2015;10(6):927-938 - PMID: 26020615 - PMCID: PMC4982460 - DOI: 10.1038/nprot.2015.054
Izgu EC, Fahrenbach AC, Zhang N, Li L, Zhang W, Larsen A, Blain JC, Szostak JW Uncovering the Thermodynamics of Monomer Binding for RNA Replication. J Am Chem Soc. 2015;137(19):6373-82 - PMID: 25901790 - PMCID: PMC4984997 - DOI: 10.1021/jacs.5b02707
Heuberger BD, Pal A, Del Frate F, Topkar VV, Szostak JW Replacing Uridine with 2-Thio-Uridine Enhances the Rate and Fidelity of Nonenzymatic RNA Primer Extension. J Am Chem Soc. 2015;137(7):2769-75 - PMID: 25654265 - PMCID: PMC4985000 - DOI: 10.1021/jacs.5b00445
Adamala K, Engelhart AE, Szostak JW Generation of functional RNAs from inactive oligonucleotide complexes by non-enzymatic primer extension. J Am Chem Soc. 2015;137(1):483-9 - PMID: 25521912 - PMCID: PMC4984999 - DOI: 10.1021/ja511564d
Hentrich C, Szostak JW Controlled growth of filamentous fatty acid vesicles under flow. Langmuir. 2014;30(49):14916-25 - PMID: 25402759 - PMCID: PMC4985002 - DOI: 10.1021/la503933x
Budin I, Prwyes N, Zhang N, Szostak JW Chain-Length Heterogeneity Allows for the Assembly of Fatty Acid Vesicles in Dilute Solutions. Biophys J. 2014;107(7):1582-1590 - PMID: 25296310 - PMCID: PMC4190651 - DOI: 10.1016/j.bpj.2014.07.067
Sheng J, Larsen A, Heuberger BD, Blain JC, Szostak JW Crystal Structure Studies of RNA Duplexes Containing s2U:A and s2U:U Base Pairs. J Am Chem Soc. 2014;136(39):13916-24 - PMID: 25188906 - PMCID: PMC4183603 - DOI: 10.1021/ja508015a
Blain JC, Szostak JW Progress Toward Synthetic Cells. Annu Rev Biochem. 2014;83:615-40 - PMID: 24606140 - DOI: 10.1146/annurev-biochem-080411-124036
Jia TZ, Hentrich C, Szostak JW Rapid RNA Exchange in Aqueous Two-Phase System and Coacervate Droplets. Orig Life Evol Biosph. 2014;44(1):1-12 - PMID: 24577897 - PMCID: PMC4141154 - DOI: 10.1007/s11084-014-9355-8
Sheng J, Li L, Engelhart AE, Gan J, Wang J, Szostak JW Structural insights into the effects of 2'-5' linkages on the RNA duplex. Proc Natl Acad Sci U S A. 2014;111(8):3050-5 - PMID: 24516151 - PMCID: PMC3939906 - DOI: 10.1073/pnas.1317799111
Li L, Szostak JW The Free Energy Landscape of Pseudorotation in 3'-5' and 2'-5' Linked Nucleic Acids. J Am Chem Soc. 2014;136(7):2858-65 - PMID: 24499340 - PMCID: PMC3982932 - DOI: 10.1021/ja412079b
Blain JC, Ricardo A, Szostak JW Synthesis and Non-Enzymatic Template-Directed Polymerization of 2'-Amino-2'-Deoxythreose Nucleotides. J Am Chem Soc. 2014;136(5):2033-9 - PMID: 24409991 - PMCID: PMC4105081 - DOI: 10.1021/ja411950n
Zhu TF, Budin I, Szostak JW Preparation of Fatty Acid micelles. Methods Enzymol. 2013;533:283-8 - PMID: 24182934 - PMCID: PMC4310231 - DOI: 10.1016/B978-0-12-420067-8.00022-2
Zhu TF, Budin I, Szostak JW Vesicle Extrusion Through Polycarbonate Track-etched Membranes using a Hand-held Mini-extruder. Methods Enzymol. 2013;533:275-82 - PMID: 24182933 - PMCID: PMC4310236 - DOI: 10.1016/B978-0-12-420067-8.00021-0
Zhu TF, Budin I, Szostak JW Preparation of Fatty Acid or Phospholipid Vesicles by Thin-film Rehydration. Methods Enzymol. 2013;533:267-74 - PMID: 24182932 - PMCID: PMC4310237 - DOI: 10.1016/B978-0-12-420067-8.00020-9
Adamala K, Szostak JW Nonenzymatic template-directed RNA synthesis inside model protocells. Science. 2013;342(6162):1098-100 - PMID: 24288333 - PMCID: PMC4104020 - DOI: 10.1126/science.1241888
Zhang S, Blain JC, Zielinska D, Gryaznov SM, Szostak JW Fast and accurate nonenzymatic copying of an RNA-like synthetic genetic polymer. Proc Natl Acad Sci U S A. 2013;110(44):17732-7 - PMID: 24101473 - PMCID: PMC3816440 - DOI: 10.1073/pnas.1312329110
Adamala K, Szostak JW Competition between model protocells driven by an encapsulated catalyst. Nat Chem. 2013;5(7):634 - PMID: 23787756
Adamala K, Szostak JW Competition between model protocells driven by an encapsulated catalyst. Nat Chem. 2013;5(6):495-501 - PMID: 23695631 - PMCID: PMC4041014 - DOI: 10.1038/nchem.1650
Engelhart AE, Powner MW, Szostak JW Functional RNAs exhibit tolerance for non-heritable 2'-5' versus 3'-5' backbone heterogeneity. Nat Chem. 2013;5(5):390-4 - PMID: 23609089 - PMCID: PMC4088963 - DOI: 10.1038/nchem.1623
Zhang S, Zhang N, Blain JC, Szostak JW Synthesis of N3'-P5'-linked phosphoramidate DNA by nonenzymatic template-directed primer extension. J Am Chem Soc. 2013;135(2):924-32 - PMID: 23252395 - PMCID: PMC3548433 - DOI: 10.1021/ja311164j
Zhang S, Zhang N, Blain JC, Szostak JW Synthesis of N3´-P5´-Phosphoramidate DNA by Non-enzymatic Template-directed Primer Extension. J Am Chem Soc. 2013;135(2):924-32 - PMID: 23252395 - PMCID: PMC3548433 - DOI: 10.1021/ja311164j
Budin I, Debnath A, Szostak JW Concentration-driven growth of model protocell membranes. J Am Chem Soc. 2012;134(51):20812-9 - PMID: 23198690 - PMCID: PMC3530389 - DOI: 10.1021/ja310382d
Budin I, Debnath A, Szostak JW Concentration-driven growth of model protocell membranes. J Am Chem Soc. 2012;134(51):20812-9 - PMID: 23198690 - PMCID: PMC3530389 - DOI: 10.1021/ja310382d
Powner MW, Zheng SL, Szostak JW Multicomponent assembly of proposed DNA precursors in water. J Am Chem Soc. 2012;134(33):13889-95 - PMID: 22839703 - PMCID: PMC3424849 - DOI: 10.1021/ja306176n
Powner MW, Zheng SL, Szostak JW Multicomponent assembly of proposed DNA precursors in water. J Am Chem Soc. 2012;134(33):13889-95 - PMID: 22839703 - PMCID: PMC3424849 - DOI: 10.1021/ja306176n
Zhu TF, Adamala K, Zhang N, Szostak JW Photochemically driven redox chemistry induces protocell membrane pearling and division. Proc Natl Acad Sci U S A. 2012;109(25):9828-32 - PMID: 22665773 - PMCID: PMC3382484 - DOI: 10.1073/pnas.1203212109
Hofmann FT, Szostak JW, Seebeck FP In vitro selection of functional lantipeptides. J Am Chem Soc. 2012;134(19):8038-41 - PMID: 22545861 - PMCID: PMC3353655 - DOI: 10.1021/ja302082d
Guillen Schlippe YV, Hartman MC, Josephson K, Szostak JW In Vitro Selection of Highly Modified Cyclic Peptides That Act as Tight Binding Inhibitors. J Am Chem Soc. 2012;134(25):10469-77 - PMID: 22428867 - PMCID: PMC3384292 - DOI: 10.1021/ja301017y
Zhang N, Zhang S, Szostak JW Activated ribonucleotides undergo a sugar pucker switch upon binding to a single-stranded RNA template. J Am Chem Soc. 2012;134(8):3691-4 - PMID: 22296305 - PMCID: PMC3448298 - DOI: 10.1021/ja212027q
Szostak JW Attempts to define life do not help to understand the origin of life. J Biomol Struct Dyn. 2012;29(4):599-600 - PMID: 22208251 - PMCID: PMC4208307 - DOI: 10.1080/073911012010524998
Szostak JW An optimal degree of physical and chemical heterogeneity for the origin of life?. Philos Trans R Soc Lond B Biol Sci. 2011;366(1580):2894-901 - PMID: 21930580 - PMCID: PMC3158921 - DOI: 10.1098/rstb.2011.0140
Trevino SG, Zhang N, Elenko MP, Lupták A, Szostak JW Evolution of functional nucleic acids in the presence of nonheritable backbone heterogeneity. Proc Natl Acad Sci U S A. 2011;108(33):13492-7 - PMID: 21825162 - PMCID: PMC3158193 - DOI: 10.1073/pnas.1107113108
Seebeck FP, Ricardo A, Szostak JW Artificial lantipeptides from in vitro translations. Chem Commun (Camb). 2011;47(21):6141-3 - PMID: 21528125 - DOI: 10.1039/c0cc05663d
Budin I, Szostak JW Physical effects underlying the transition from primitive to modern cell membranes. Proc Natl Acad Sci U S A. 2011;108(13):5249-54 - PMID: 21402937 - PMCID: PMC3069173 - DOI: 10.1073/pnas.1100498108
Subtelny AO, Hartman MC, Szostak JW Optimal codon choice can improve the efficiency and fidelity of N-methyl amino acid incorporation into peptides by in-vitro translation. Angew Chem Int Ed Engl. 2011;50(14):3164-7 - PMID: 21381166 - PMCID: PMC4006073 - DOI: 10.1002/anie.201007686
Powner MW, Sutherland JD, Szostak JW Chemoselective multicomponent one-pot assembly of purine precursors in water. J Am Chem Soc. 2010;132(46):16677-88 - PMID: 21043502 - PMCID: PMC2984373 - DOI: 10.1021/ja108197s
Szostak JW DNA ends: just the beginning (Nobel lecture). Angew Chem Int Ed Engl. 2010;49(41):7386-404 - PMID: 20818632 - DOI: 10.1002/anie.201000635
Elenko MP, Szostak JW, van Oijen AM Single-molecule binding experiments on long time scales. Rev Sci Instrum. 2010;81(8):083705 - PMID: 20815611 - DOI: 10.1063/1.3473936
Budin I, Szostak JW Expanding roles for diverse physical phenomena during the origin of life. Annu Rev Biophys. 2010;39:245-63 - PMID: 20192779 - PMCID: PMC4992673 - DOI: 10.1146/annurev.biophys.050708.133753
Schrum JP, Zhu TF, Szostak JW The origins of cellular life. Cold Spring Harb Perspect Biol. 2010;2(9):a002212 - PMID: 20484387 - PMCID: PMC2926753 - DOI: 10.1101/cshperspect.a002212
Rajamani S, Ichida JK, Antal T, Treco DA, Leu K, Nowak MA, Szostak JW, Chen IA Effect of stalling after mismatches on the error catastrophe in nonenzymatic nucleic acid replication. J Am Chem Soc. 2010;132(16):5880-5 - PMID: 20359213 - PMCID: PMC2857888 - DOI: 10.1021/ja100780p
Bruckner RJ, Mansy SS, Ricardo A, Mahadevan L, Szostak JW Flip-flop-induced relaxation of bending energy: implications for membrane remodeling. Biophys J. 2009;97(12):3113-22 - PMID: 20006948 - PMCID: PMC2793357 - DOI: 10.1016/j.bpj.2009.09.025
Schrum JP, Ricardo A, Krishnamurthy M, Blain JC, Szostak JW Efficient and rapid template-directed nucleic acid copying using 2'-amino-2',3'-dideoxyribonucleoside-5'-phosphorimidazolide monomers. J Am Chem Soc. 2009;131(40):14560-70 - PMID: 19757789 - PMCID: PMC2759813 - DOI: 10.1021/ja906557v
Mansy SS, Szostak JW Reconstructing the emergence of cellular life through the synthesis of model protocells. Cold Spring Harb Symp Quant Biol. 2009;74:47-54 - PMID: 19734203 - DOI: 10.1101/sqb.2009.74.014
Ricardo A, Szostak JW Origin of life on earth. Sci Am. 2009;301(3):54-61 - PMID: 19708528 - DOI: 10.1038/scientificamerican0909-54
Lin S, Horning DP, Szostak JW, Chaput JC Conformational analysis of DNA repair intermediates by time-resolved fluorescence spectroscopy. J Phys Chem A. 2009;113(35):9585-7 - PMID: 19673467 - PMCID: PMC2733762 - DOI: 10.1021/jp906746w
Budin I, Bruckner RJ, Szostak JW Formation of protocell-like vesicles in a thermal diffusion column. J Am Chem Soc. 2009;131(28):9628-9 - PMID: 19601679 - PMCID: PMC2710859 - DOI: 10.1021/ja9029818
Elenko MP, Szostak JW, van Oijen AM Single-molecule imaging of an in vitro-evolved RNA aptamer reveals homogeneous ligand binding kinetics. J Am Chem Soc. 2009;131(29):9866-7 - PMID: 19572753 - PMCID: PMC2716146 - DOI: 10.1021/ja901880v
Szostak JW Origins of life: Systems chemistry on early Earth. Nature. 2009;459(7244):171-2 - PMID: 19444196 - DOI: 10.1038/459171a
Litovchick A, Szostak JW Retraction for Litovchick and Szostak. "Selection of cyclic peptide aptamers to HCV IRES RNA using mRNA display". Proc Natl Acad Sci U S A. 2009;106(17):7263 - PMID: 19380733 - PMCID: PMC2678432 - DOI: 10.1073/pnas.0903110106
Zhu TF, Szostak JW Preparation of large monodisperse vesicles. PLoS One. 2009;4(4):e5009 - PMID: 19347043 - PMCID: PMC2661144 - DOI: 10.1371/journal.pone.0005009
Zhu TF, Szostak JW Coupled growth and division of model protocell membranes. J Am Chem Soc. 2009;131(15):5705-13 - PMID: 19323552 - PMCID: PMC2669828 - DOI: 10.1021/ja900919c
Chen JJ, Tsai CH, Cai X, Horhota AT, McLaughlin LW, Szostak JW Enzymatic primer-extension with glycerol-nucleoside triphosphates on DNA templates. PLoS One. 2009;4(3):e4949 - PMID: 19305495 - PMCID: PMC2654545 - DOI: 10.1371/journal.pone.0004949
Chen JJ, Cai X, Szostak JW N2'-->p3' phosphoramidate glycerol nucleic acid as a potential alternative genetic system. J Am Chem Soc. 2009;131(6):2119-21 - PMID: 19166350 - PMCID: PMC2722806 - DOI: 10.1021/ja809069b
Litovchick A, Szostak JW Selection of cyclic peptide aptamers to HCV IRES RNA using mRNA display. Proc Natl Acad Sci U S A. 2008;105(40):15293-8 - PMID: 18824687 - PMCID: PMC2556359 - DOI: 10.1073/pnas.0805837105
Mansy SS, Szostak JW Thermostability of model protocell membranes. Proc Natl Acad Sci U S A. 2008;105(36):13351-5 - PMID: 18768808 - PMCID: PMC2528865 - DOI: 10.1073/pnas.0805086105
Mansy SS, Schrum JP, Krishnamurthy M, Tobé S, Treco DA, Szostak JW Template-directed synthesis of a genetic polymer in a model protocell. Nature. 2008;454(7200):122-5 - PMID: 18528332 - PMCID: PMC2743009 - DOI: 10.1038/nature07018
Subtelny AO, Hartman MC, Szostak JW Ribosomal synthesis of N-methyl peptides. J Am Chem Soc. 2008;130(19):6131-6 - PMID: 18402453 - PMCID: PMC2728122 - DOI: 10.1021/ja710016v
Monnard PA, Szostak JW Metal-ion catalyzed polymerization in the eutectic phase in water-ice: a possible approach to template-directed RNA polymerization. J Inorg Biochem. 2008;102(5-6):1104-11 - PMID: 18329104 - DOI: 10.1016/j.jinorgbio.2008.01.026
Hartman MC, Josephson K, Lin CW, Szostak JW An expanded set of amino acid analogs for the ribosomal translation of unnatural peptides. PLoS One. 2007;2(10):e972 - PMID: 17912351 - PMCID: PMC1989143 - DOI: 10.1371/journal.pone.0000972
Tsai CH, Chen J, Szostak JW Enzymatic synthesis of DNA on glycerol nucleic acid templates without stable duplex formation between product and template. Proc Natl Acad Sci U S A. 2007;104(37):14598-603 - PMID: 17785419 - PMCID: PMC1976233 - DOI: 10.1073/pnas.0704211104
Seelig B, Szostak JW Selection and evolution of enzymes from a partially randomized non-catalytic scaffold. Nature. 2007;448(7155):828-31 - PMID: 17700701 - PMCID: PMC4476047 - DOI: 10.1038/nature06032
Mansy SS, Zhang J, Kümmerle R, Nilsson M, Chou JJ, Szostak JW, Chaput JC Structure and evolutionary analysis of a non-biological ATP-binding protein. J Mol Biol. 2007;371(2):501-13 - PMID: 17583732 - DOI: 10.1016/j.jmb.2007.05.062
Smith MD, Rosenow MA, Wang M, Allen JP, Szostak JW, Chaput JC Structural insights into the evolution of a non-biological protein: importance of surface residues in protein fold optimization. PLoS One. 2007;2(5):e467 - PMID: 17520026 - PMCID: PMC1867856 - DOI: 10.1371/journal.pone.0000467
Hazen RM, Griffin PL, Carothers JM, Szostak JW Functional information and the emergence of biocomplexity. Proc Natl Acad Sci U S A. 2007;104 Suppl 1:8574-81 - PMID: 17494745 - PMCID: PMC1876432 - DOI: 10.1073/pnas.0701744104
Meena , Sam M, Pierce K, Szostak JW, McLaughlin LW 2',3'-Dideoxy-3'-thionucleoside triphosphates: syntheses and polymerase substrate activities. Org Lett. 2007;9(6):1161-3 - PMID: 17319676 - DOI: 10.1021/ol070147w
Horhota AT, Szostak JW, McLaughlin LW Glycerol nucleoside triphosphates: synthesis and polymerase substrate activities. Org Lett. 2006;8(23):5345-7 - PMID: 17078714 - DOI: 10.1021/ol062232u
Blackburn EH, Greider CW, Szostak JW Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging. Nat Med. 2006;12(10):1133-8 - PMID: 17024208 - DOI: 10.1038/nm1006-1133
Salehi-Ashtiani K, Lupták A, Litovchick A, Szostak JW A genomewide search for ribozymes reveals an HDV-like sequence in the human CPEB3 gene. Science. 2006;313(5794):1788-92 - PMID: 16990549 - DOI: 10.1126/science.1129308
Carothers JM, Oestreich SC, Szostak JW Aptamers selected for higher-affinity binding are not more specific for the target ligand. J Am Chem Soc. 2006;128(24):7929-37 - PMID: 16771507 - PMCID: PMC4287982 - DOI: 10.1021/ja060952q
Seebeck FP, Szostak JW Ribosomal synthesis of dehydroalanine-containing peptides. J Am Chem Soc. 2006;128(22):7150-1 - PMID: 16734454 - PMCID: PMC2572134 - DOI: 10.1021/ja060966w
Hartman MC, Josephson K, Szostak JW Enzymatic aminoacylation of tRNA with unnatural amino acids. Proc Natl Acad Sci U S A. 2006;103(12):4356-61 - PMID: 16537388 - PMCID: PMC1450175 - DOI: 10.1073/pnas.0509219103
Carothers JM, Davis JH, Chou JJ, Szostak JW Solution structure of an informationally complex high-affinity RNA aptamer to GTP. RNA. 2006;12(4):567-79 - PMID: 16510427 - PMCID: PMC1421093 - DOI: 10.1261/rna.2251306
Cho GS, Szostak JW Directed evolution of ATP binding proteins from a zinc finger domain by using mRNA display. Chem Biol. 2006;13(2):139-47 - PMID: 16492562 - DOI: 10.1016/j.chembiol.2005.10.015
Fujikawa SM, Chen IA, Szostak JW Shrink-wrap vesicles. Langmuir. 2005;21(26):12124-9 - PMID: 16342983 - PMCID: PMC2548281 - DOI: 10.1021/la052590q
Plummer KA, Carothers JM, Yoshimura M, Szostak JW, Verdine GL In vitro selection of RNA aptamers against a composite small molecule-protein surface. Nucleic Acids Res. 2005;33(17):5602-10 - PMID: 16199752 - PMCID: PMC1240114 - DOI: 10.1093/nar/gki867
Ichida JK, Horhota A, Zou K, McLaughlin LW, Szostak JW High fidelity TNA synthesis by Therminator polymerase. Nucleic Acids Res. 2005;33(16):5219-25 - PMID: 16157867 - PMCID: PMC1214552 - DOI: 10.1093/nar/gki840
Chen IA, Salehi-Ashtiani K, Szostak JW RNA catalysis in model protocell vesicles. J Am Chem Soc. 2005;127(38):13213-9 - PMID: 16173749 - PMCID: PMC5072289 - DOI: 10.1021/ja051784p
Josephson K, Hartman MC, Szostak JW Ribosomal synthesis of unnatural peptides. J Am Chem Soc. 2005;127(33):11727-35 - PMID: 16104750 - DOI: 10.1021/ja0515809
Horhota A, Zou K, Ichida JK, Yu B, McLaughlin LW, Szostak JW, Chaput JC Kinetic analysis of an efficient DNA-dependent TNA polymerase. J Am Chem Soc. 2005;127(20):7427-34 - PMID: 15898792 - PMCID: PMC5042361 - DOI: 10.1021/ja0428255
Shen X, Valencia CA, Szostak JW, Szostak J, Dong B, Liu R Scanning the human proteome for calmodulin-binding proteins. Proc Natl Acad Sci U S A. 2005;102(17):5969-74 - PMID: 15840729 - PMCID: PMC1087907 - DOI: 10.1073/pnas.0407928102
Sacerdote MG, Szostak JW Semipermeable lipid bilayers exhibit diastereoselectivity favoring ribose. Proc Natl Acad Sci U S A. 2005;102(17):6004-8 - PMID: 15831588 - PMCID: PMC556129 - DOI: 10.1073/pnas.0408440102
Zou K, Horhota A, Yu B, Szostak JW, McLaughlin LW Synthesis of alpha-L-threofuranosyl nucleoside triphosphates (tNTPs). Org Lett. 2005;7(8):1485-7 - PMID: 15816733 - PMCID: PMC5022784 - DOI: 10.1021/ol050081+
Ichida JK, Zou K, Horhota A, Yu B, McLaughlin LW, Szostak JW An in vitro selection system for TNA. J Am Chem Soc. 2005;127(9):2802-3 - PMID: 15740086 - PMCID: PMC5072288 - DOI: 10.1021/ja045364w
Hanczyc MM, Szostak JW Replicating vesicles as models of primitive cell growth and division. Curr Opin Chem Biol. 2004;8(6):660-4 - PMID: 15556412 - DOI: 10.1016/j.cbpa.2004.10.002
Chen IA, Roberts RW, Szostak JW The emergence of competition between model protocells. Science. 2004;305(5689):1474-6 - PMID: 15353806 - PMCID: PMC4484590 - DOI: 10.1126/science.1100757
Chen IA, Szostak JW A kinetic study of the growth of fatty acid vesicles. Biophys J. 2004;87(2):988-98 - PMID: 15298905 - PMCID: PMC1304506 - DOI: 10.1529/biophysj.104.039875
Sazani PL, Larralde R, Szostak JW A small aptamer with strong and specific recognition of the triphosphate of ATP. J Am Chem Soc. 2004;126(27):8370-1 - PMID: 15237981 - PMCID: PMC4983724 - DOI: 10.1021/ja049171k
Chaput JC, Szostak JW Evolutionary optimization of a nonbiological ATP binding protein for improved folding stability. Chem Biol. 2004;11(6):865-74 - PMID: 15217619 - DOI: 10.1016/j.chembiol.2004.04.006
Chen IA, Szostak JW Membrane growth can generate a transmembrane pH gradient in fatty acid vesicles. Proc Natl Acad Sci U S A. 2004;101(21):7965-70 - PMID: 15148394 - PMCID: PMC419540 - DOI: 10.1073/pnas.0308045101
Carothers JM, Oestreich SC, Davis JH, Szostak JW Informational complexity and functional activity of RNA structures. J Am Chem Soc. 2004;126(16):5130-7 - PMID: 15099096 - PMCID: PMC5042360 - DOI: 10.1021/ja031504a
Huang Z, Szostak JW Evolution of aptamers with a new specificity and new secondary structures from an ATP aptamer. RNA. 2003;9(12):1456-63 - PMID: 14624002 - PMCID: PMC1370500 - DOI: 10.1261/rna.5990203
Hanczyc MM, Fujikawa SM, Szostak JW Experimental models of primitive cellular compartments: encapsulation, growth, and division. Science. 2003;302(5645):618-22 - PMID: 14576428 - PMCID: PMC4484575 - DOI: 10.1126/science.1089904
Chaput JC, Szostak JW TNA synthesis by DNA polymerases. J Am Chem Soc. 2003;125(31):9274-5 - PMID: 12889939 - DOI: 10.1021/ja035917n
Vaish NK, Larralde R, Fraley AW, Szostak JW, McLaughlin LW A novel, modification-dependent ATP-binding aptamer selected from an RNA library incorporating a cationic functionality. Biochemistry. 2003;42(29):8842-51 - PMID: 12873145 - DOI: 10.1021/bi027354i
Szostak JW Functional information: Molecular messages. Nature. 2003;423(6941):689 - PMID: 12802312 - DOI: 10.1038/423689a
Huang Z, Szostak JW Selective labeling and detection of specific RNAs in an RNA mixture. Anal Biochem. 2003;315(1):129-33 - PMID: 12672421 - DOI: 10.1016/s0003-2697(02)00701-7
Chaput JC, Ichida JK, Szostak JW DNA polymerase-mediated DNA synthesis on a TNA template. J Am Chem Soc. 2003;125(4):856-7 - PMID: 12537469 - DOI: 10.1021/ja028589k
Szostak JW Molecular biology: RNA gets a grip on translation. Nature. 2002;419(6910):890-1 - PMID: 12410294 - DOI: 10.1038/419890a
Baggio R, Burgstaller P, Hale SP, Putney AR, Lane M, Lipovsek D, Wright MC, Roberts RW, Liu R, Szostak JW, Wagner RW Identification of epitope-like consensus motifs using mRNA display. J Mol Recognit. 2002;15(3):126-34 - PMID: 12203838 - DOI: 10.1002/jmr.567
Davis JH, Szostak JW Isolation of high-affinity GTP aptamers from partially structured RNA libraries. Proc Natl Acad Sci U S A. 2002;99(18):11616-21 - PMID: 12185247 - PMCID: PMC129318 - DOI: 10.1073/pnas.182095699
Keefe AD, Wilson DS, Seelig B, Szostak JW One-step purification of recombinant proteins using a nanomolar-affinity streptavidin-binding peptide, the SBP-Tag. Protein Expr Purif. 2001;23(3):440-6 - PMID: 11722181 - DOI: 10.1006/prep.2001.1515
Salehi-Ashtiani K, Szostak JW In vitro evolution suggests multiple origins for the hammerhead ribozyme. Nature. 2001;414(6859):82-4 - PMID: 11689947 - DOI: 10.1038/35102081
Keefe AD, Szostak JW Functional proteins from a random-sequence library. Nature. 2001;410(6829):715-8 - PMID: 11287961 - PMCID: PMC4476321 - DOI: 10.1038/35070613
Wilson DS, Keefe AD, Szostak JW The use of mRNA display to select high-affinity protein-binding peptides. Proc Natl Acad Sci U S A. 2001;98(7):3750-5 - PMID: 11274392 - PMCID: PMC31124 - DOI: 10.1073/pnas.061028198
Szostak JW, Bartel DP, Luisi PL Synthesizing life. Nature. 2001;409(6818):387-90 - PMID: 11201752 - DOI: 10.1038/35053176
Liu R, Barrick JE, Szostak JW, Roberts RW Optimized synthesis of RNA-protein fusions for in vitro protein selection. Methods Enzymol. 2000;318:268-93 - PMID: 10889994 - DOI: 10.1016/s0076-6879(00)18058-9
Szostak JW In vitro selection and directed evolution. Harvey Lect. 2000;93:95-118 - PMID: 10941421
Vaish NK, Fraley AW, Szostak JW, McLaughlin LW Expanding the structural and functional diversity of RNA: analog uridine triphosphates as candidates for in vitro selection of nucleic acids. Nucleic Acids Res. 2000;28(17):3316-22 - PMID: 10954600 - PMCID: PMC110695 - DOI: 10.1093/nar/28.17.3316
Wilson DS, Szostak JW In vitro selection of functional nucleic acids. Annu Rev Biochem. 2000;68:611-47 - PMID: 10872462 - DOI: 10.1146/annurev.biochem.68.1.611
Cho G, Keefe AD, Liu R, Wilson DS, Szostak JW Constructing high complexity synthetic libraries of long ORFs using in vitro selection. J Mol Biol. 2000;297(2):309-19 - PMID: 10715203 - DOI: 10.1006/jmbi.2000.3571
Lee N, Bessho Y, Wei K, Szostak JW, Suga H Ribozyme-catalyzed tRNA aminoacylation. Nat Struct Biol. 2000;7(1):28-33 - PMID: 10625423 - DOI: 10.1038/71225
Holeman LA, Robinson SL, Szostak JW, Wilson C Isolation and characterization of fluorophore-binding RNA aptamers. Fold Des. 1999;3(6):423-31 - PMID: 9889155 - DOI: 10.1016/S1359-0278(98)00059-5
Wilson C, Szostak JW Isolation of a fluorophore-specific DNA aptamer with weak redox activity. Chem Biol. 1998;5(11):609-17 - PMID: 9831529 - DOI: 10.1016/s1074-5521(98)90289-7
Suga H, Cowan JA, Szostak JW Unusual metal ion catalysis in an acyl-transferase ribozyme. Biochemistry. 1998;37(28):10118-25 - PMID: 9665717 - DOI: 10.1021/bi980432a
Suga H, Lohse PA, Szostak JW Structural and kinetic characterization of an acyl transferase ribozyme. J Am Chem Soc. 1998;120(6):1151-6 - PMID: 11541113 - DOI: 10.1021/ja972472s
Roberts RW, Szostak JW RNA-peptide fusions for the in vitro selection of peptides and proteins. Proc Natl Acad Sci U S A. 1997;94(23):12297-302 - PMID: 9356443 - PMCID: PMC24913 - DOI: 10.1073/pnas.94.23.12297
Dieckmann T, Butcher SE, Sassanfar M, Szostak JW, Feigon J Mutant ATP-binding RNA aptamers reveal the structural basis for ligand binding. J Mol Biol. 1997;273(2):467-78 - PMID: 9344753 - DOI: 10.1006/jmbi.1997.1329
Chapman KB, Szostak JW In vitro selection of catalytic RNAs. Curr Opin Struct Biol. 1997;4:618-22 - PMID: 11539575 - DOI: 10.1016/s0959-440x(94)90227-5
Hager AJ, Szostak JW Isolation of novel ribozymes that ligate AMP-activated RNA substrates. Chem Biol. 1997;4(8):607-17 - PMID: 9281527 - DOI: 10.1016/s1074-5521(97)90246-5
Szostak JW Introduction: Combinatorial Chemistry. Chem Rev. 1997;97(2):347-348 - PMID: 11848873 - DOI: 10.1021/cr9700080
Huang Z, Szostak JW A simple method for 3'-labeling of RNA. Nucleic Acids Res. 1996;24(21):4360-1 - PMID: 8932396 - PMCID: PMC146232 - DOI: 10.1093/nar/24.21.4360
Hager AJ, Pollard JD, Szostak JW Ribozymes: aiming at RNA replication and protein synthesis. Chem Biol. 1996;3(9):717-25 - PMID: 8939686 - DOI: 10.1016/s1074-5521(96)90246-x
Lohse PA, Szostak JW Ribozyme-catalysed amino-acid transfer reactions. Nature. 1996;381(6581):442-4 - PMID: 8632803 - DOI: 10.1038/381442a0
Rohatgi R, Bartel DP, Szostak JW Nonenzymatic, template-directed ligation of oligoribonucleotides is highly regioselective for the formation of 3'-5' phosphodiester bonds. J Am Chem Soc. 1996;118(14):3340-4 - PMID: 11539268 - DOI: 10.1021/ja9537134
Rohatgi R, Bartel DP, Szostak JW Kinetic and mechanistic analysis of nonenzymatic, template-directed oligoribonucleotide ligation. J Am Chem Soc. 1996;118(14):3332-9 - PMID: 11539267 - DOI: 10.1021/ja953712b
Lorsch JR, Szostak JW Chance and necessity in the selection of nucleic acid catalysts. Acc Chem Res. 1996;29(2):103-10 - PMID: 11539421 - DOI: 10.1021/ar9501378
Lorsch JR, Szostak JW Kinetic and thermodynamic characterization of the reaction catalyzed by a polynucleotide kinase ribozyme. Biochemistry. 1995;34(46):15315-27 - PMID: 7578148 - DOI: 10.1021/bi00046a041
Lorsch JR, Bartel DP, Szostak JW Reverse transcriptase reads through a 2'-5'linkage and a 2'-thiophosphate in a template. Nucleic Acids Res. 1995;23(15):2811-4 - PMID: 7544885 - PMCID: PMC307115 - DOI: 10.1093/nar/23.15.2811
Ekland EH, Szostak JW, Bartel DP Structurally complex and highly active RNA ligases derived from random RNA sequences. Science. 1995;269(5222):364-70 - PMID: 7618102 - DOI: 10.1126/science.7618102
Cuenoud B, Szostak JW A DNA metalloenzyme with DNA ligase activity. Nature. 1995;375(6532):611-4 - PMID: 7791880 - DOI: 10.1038/375611a0
Chapman KB, Szostak JW Isolation of a ribozyme with 5'-5' ligase activity. Chem Biol. 1995;2(5):325-33 - PMID: 9383434 - DOI: 10.1016/1074-5521(95)90051-9
Wilson C, Szostak JW In vitro evolution of a self-alkylating ribozyme. Nature. 1995;374(6525):777-82 - PMID: 7723823 - DOI: 10.1038/374777a0
Whoriskey SK, Usman N, Szostak JW Total chemical synthesis of a ribozyme derived from a group I intron. Proc Natl Acad Sci U S A. 1995;92(7):2465-9 - PMID: 7708666 - PMCID: PMC42238 - DOI: 10.1073/pnas.92.7.2465
Lauhon CT, Szostak JW RNA aptamers that bind flavin and nicotinamide redox cofactors. J Am Chem Soc. 1995;117(4):1246-57 - PMID: 11539282 - DOI: 10.1021/ja00109a008
Huizenga DE, Szostak JW A DNA aptamer that binds adenosine and ATP. Biochemistry. 1995;34(2):656-65 - PMID: 7819261 - DOI: 10.1021/bi00002a033
Hanna M, Szostak JW Suppression of mutations in the core of the Tetrahymena ribozyme by spermidine, ethanol and by substrate stabilization. Nucleic Acids Res. 1994;22(24):5326-31 - PMID: 7816622 - PMCID: PMC332078 - DOI: 10.1093/nar/22.24.5326
Lorsch JR, Szostak JW In vitro evolution of new ribozymes with polynucleotide kinase activity. Nature. 1994;371(6492):31-6 - PMID: 7521014 - DOI: 10.1038/371031a0
Peterson RD, Bartel DP, Szostak JW, Horvath SJ, Feigon J 1H NMR studies of the high-affinity Rev binding site of the Rev responsive element of HIV-1 mRNA: base pairing in the core binding element. Biochemistry. 1994;33(18):5357-66 - PMID: 8180157 - DOI: 10.1021/bi00184a001
Lin CW, Hanna M, Szostak JW Evidence that the guanosine substrate of the Tetrahymena ribozyme is bound in the anti conformation and that N7 contributes to binding. Biochemistry. 1994;33(9):2703-7 - PMID: 8117735 - DOI: 10.1021/bi00175a045
Lorsch JR, Szostak JW In vitro selection of RNA aptamers specific for cyanocobalamin. Biochemistry. 1994;33(4):973-82 - PMID: 7508262 - DOI: 10.1021/bi00170a016
Green R, Szostak JW In vitro genetic analysis of the hinge region between helical elements P5-P4-P6 and P7-P3-P8 in the sunY group I self-splicing intron. J Mol Biol. 1994;235(1):140-55 - PMID: 7507168 - DOI: 10.1016/s0022-2836(05)80022-1
Bartel DP, Szostak JW Isolation of new ribozymes from a large pool of random sequences [see comment]. Science. 1993;261(5127):1411-8 - PMID: 7690155 - DOI: 10.1126/science.7690155
Sassanfar M, Szostak JW An RNA motif that binds ATP. Nature. 1993;364(6437):550-3 - PMID: 7687750 - DOI: 10.1038/364550a0
Doudna JA, Usman N, Szostak JW Ribozyme-catalyzed primer extension by trinucleotides: a model for the RNA-catalyzed replication of RNA. Biochemistry. 1993;32(8):2111-5 - PMID: 7680575 - DOI: 10.1021/bi00059a032
Szostak JW Ribozymes. Evolution ex vivo. Nature. 1993;361(6408):119-20 - PMID: 7678448 - DOI: 10.1038/361119a0
Green R, Szostak JW Selection of a ribozyme that functions as a superior template in a self-copying reaction. Science. 1992;258(5090):1910-5 - PMID: 1470913 - DOI: 10.1126/science.1470913
Ross LO, Treco D, Nicolas A, Szostak JW, Dawson D Meiotic recombination on artificial chromosomes in yeast. Genetics. 1992;131(3):541-50 - PMID: 1385793 - PMCID: PMC1205028 - DOI: 10.1093/genetics/131.3.541
Park EC, Szostak JW ARD1 and NAT1 proteins form a complex that has N-terminal acetyltransferase activity. EMBO J. 1992;11(6):2087-93 - PMID: 1600941 - PMCID: PMC556675 - DOI: 10.1002/j.1460-2075.1992.tb05267.x
Szostak JW In vitro genetics. Trends Biochem Sci. 1992;17(3):89-93 - PMID: 1384177 - DOI: 10.1016/0968-0004(92)90242-2
Ellington AD, Szostak JW Selection in vitro of single-stranded DNA molecules that fold into specific ligand-binding structures. Nature. 1992;355(6363):850-2 - PMID: 1538766 - DOI: 10.1038/355850a0
Park EC, Finley D, Szostak JW A strategy for the generation of conditional mutations by protein destabilization. Proc Natl Acad Sci U S A. 1992;89(4):1249-52 - PMID: 1311090 - PMCID: PMC48426 - DOI: 10.1073/pnas.89.4.1249
Sun H, Dawson D, Szostak JW Genetic and physical analyses of sister chromatid exchange in yeast meiosis. Mol Cell Biol. 1991;11(12):6328-36 - PMID: 1944292 - PMCID: PMC361828 - DOI: 10.1128/mcb.11.12.6328
Bartel DP, Zapp ML, Green MR, Szostak JW HIV-1 Rev regulation involves recognition of non-Watson-Crick base pairs in viral RNA. Cell. 1991;67(3):529-36 - PMID: 1934059 - DOI: 10.1016/0092-8674(91)90527-6
Green R, Szostak JW, Benner SA, Rich A, Usman N Synthesis of RNA containing inosine: analysis of the sequence requirements for the 5' splice site of the Tetrahymena group I intron. Nucleic Acids Res. 1991;19(15):4161-6 - PMID: 1714564 - PMCID: PMC328556 - DOI: 10.1093/nar/19.15.4161
Bartel DP, Doudna JA, Usman N, Szostak JW Template-directed primer extension catalyzed by the Tetrahymena ribozyme. Mol Cell Biol. 1991;11(6):3390-4 - PMID: 2038341 - PMCID: PMC360195 - DOI: 10.1128/mcb.11.6.3390
Sun H, Treco D, Szostak JW Extensive 3'-overhanging, single-stranded DNA associated with the meiosis-specific double-strand breaks at the ARG4 recombination initiation site. Cell. 1991;64(6):1155-61 - PMID: 2004421 - DOI: 10.1016/0092-8674(91)90270-9
Pace U, Szostak JW Mutations in a semiconserved region of the Tetrahymena intron. FEBS Lett. 1991;280(1):171-4 - PMID: 2009960 - DOI: 10.1016/0014-5793(91)80230-z
Doudna JA, Couture S, Szostak JW A multisubunit ribozyme that is a catalyst of and template for complementary strand RNA synthesis. Science. 1991;251(5001):1605-8 - PMID: 1707185 - DOI: 10.1126/science.1707185
Schultes NP, Szostak JW A poly(dA.dT) tract is a component of the recombination initiation site at the ARG4 locus in Saccharomyces cerevisiae. Mol Cell Biol. 1991;11(1):322-8 - PMID: 1986228 - PMCID: PMC359622 - DOI: 10.1128/mcb.11.1.322
Schultes NP, Ellington AD, Cherry JM, Szostak JW Saccharomyces cerevisiae homoserine kinase is homologous to prokaryotic homoserine kinases. Gene. 1990;96(2):177-80 - PMID: 2176637 - DOI: 10.1016/0378-1119(90)90250-u
Schultes NP, Szostak JW Decreasing gradients of gene conversion on both sides of the initiation site for meiotic recombination at the ARG4 locus in yeast. Genetics. 1990;126(4):813-22 - PMID: 1981763 - PMCID: PMC1204280 - DOI: 10.1093/genetics/126.4.813
Doudna JA, Szostak JW, Rich A, Usman N Chemical synthesis of oligoribonucleotides containing 2-aminopurine: substrates for the investigation of ribozyme function. J Org Chem. 1990;55(21):5547-9 - PMID: 11540922 - DOI: 10.1021/jo00308a003
Couture S, Ellington AD, Gerber AS, Cherry JM, Doudna JA, Green R, Hanna M, Pace U, Rajagopal J, Szostak JW Mutational analysis of conserved nucleotides in a self-splicing group I intron. J Mol Biol. 1990;215(3):345-58 - PMID: 1700131 - DOI: 10.1016/s0022-2836(05)80356-0
Michel F, Ellington AD, Couture S, Szostak JW Phylogenetic and genetic evidence for base-triples in the catalytic domain of group I introns. Nature. 1990;347(6293):578-80 - PMID: 2215683 - DOI: 10.1038/347578a0
Lichten M, Goyon C, Schultes NP, Treco D, Szostak JW, Haber JE, Nicolas A Detection of heteroduplex DNA molecules among the products of Saccharomyces cerevisiae meiosis. Proc Natl Acad Sci U S A. 1990;87(19):7653-7 - PMID: 2217196 - PMCID: PMC54806 - DOI: 10.1073/pnas.87.19.7653
Park EC, Szostak JW Point mutations in the yeast histone H4 gene prevent silencing of the silent mating type locus HML. Mol Cell Biol. 1990;10(9):4932-4 - PMID: 2117703 - PMCID: PMC361112 - DOI: 10.1128/mcb.10.9.4932
Green R, Ellington AD, Szostak JW In vitro genetic analysis of the Tetrahymena self-splicing intron. Nature. 1990;347(6291):406-8 - PMID: 2215650 - DOI: 10.1038/347406a0
Ellington AD, Szostak JW In vitro selection of RNA molecules that bind specific ligands. Nature. 1990;346(6287):818-22 - PMID: 1697402 - DOI: 10.1038/346818a0
Doudna JA, Szostak JW Miniribozymes, small derivatives of the sunY intron, are catalytically active. Mol Cell Biol. 1989;9(12):5480-3 - PMID: 2685567 - PMCID: PMC363717 - DOI: 10.1128/mcb.9.12.5480
Michel F, Hanna M, Green R, Bartel DP, Szostak JW The guanosine binding site of the Tetrahymena ribozyme. Nature. 1989;342(6248):391-5 - PMID: 2685606 - DOI: 10.1038/342391a0
Doudna JA, Cormack BP, Szostak JW RNA structure, not sequence, determines the 5' splice-site specificity of a group I intron. Proc Natl Acad Sci U S A. 1989;86(19):7402-6 - PMID: 2678103 - PMCID: PMC298070 - DOI: 10.1073/pnas.86.19.7402
Doudna JA, Szostak JW RNA-catalysed synthesis of complementary-strand RNA. Nature. 1989;339(6225):519-22 - PMID: 2660003 - DOI: 10.1038/339519a0
Lundblad V, Szostak JW A mutant with a defect in telomere elongation leads to senescence in yeast. Cell. 1989;57(4):633-43 - PMID: 2655926 - DOI: 10.1016/0092-8674(89)90132-3
Rajagopal J, Doudna JA, Szostak JW Stereochemical course of catalysis by the Tetrahymena ribozyme. Science. 1989;244(4905):692-4 - PMID: 2470151 - DOI: 10.1126/science.2470151
Nicolas A, Treco D, Schultes NP, Szostak JW An initiation site for meiotic gene conversion in the yeast Saccharomyces cerevisiae. Nature. 1989;338(6210):35-9 - PMID: 2537472 - DOI: 10.1038/338035a0
Sun H, Treco D, Schultes NP, Szostak JW Double-strand breaks at an initiation site for meiotic gene conversion. Nature. 1989;338(6210):87-90 - PMID: 2645528 - DOI: 10.1038/338087a0
Szostak JW Telomerase: the beginning of the ends. Nature. 1989;337(6205):303-4 - PMID: 2765013 - DOI: 10.1038/337303a0
Orr-Weaver TL, Nicolas A, Szostak JW Gene conversion adjacent to regions of double-strand break repair. Mol Cell Biol. 1988;8(12):5292-8 - PMID: 3072478 - PMCID: PMC365631 - DOI: 10.1128/mcb.8.12.5292
Murray AW, Claus TE, Szostak JW Characterization of two telomeric DNA processing reactions in Saccharomyces cerevisiae. Mol Cell Biol. 1988;8(11):4642-50 - PMID: 3062364 - PMCID: PMC365553 - DOI: 10.1128/mcb.8.11.4642
Doudna JA, Gerber AS, Cherry JM, Szostak JW Genetic dissection of an RNA enzyme. Cold Spring Harb Symp Quant Biol. 1988;52:173-80 - PMID: 2456876 - DOI: 10.1101/sqb.1987.052.01.022
Allshire RC, Gosden JR, Cross SH, Cranston G, Rout D, Sugawara N, Szostak JW, Fantes PA, Hastie ND Telomeric repeat from T. thermophila cross hybridizes with human telomeres. Nature. 1988;332(6165):656-9 - PMID: 2833706 - DOI: 10.1038/332656a0
Matsumoto T, Fukui K, Niwa O, Sugawara N, Szostak JW, Yanagida M Identification of healed terminal DNA fragments in linear minichromosomes of Schizosaccharomyces pombe. Mol Cell Biol. 1987;7(12):4424-30 - PMID: 2830493 - PMCID: PMC368126 - DOI: 10.1128/mcb.7.12.4424
Murray AW, Szostak JW Artificial chromosomes. Sci Am. 1987;257(5):62-8 - PMID: 3317814 - DOI: 10.1038/scientificamerican1187-62
Reynolds AE, Murray AW, Szostak JW Roles of the 2 microns gene products in stable maintenance of the 2 microns plasmid of Saccharomyces cerevisiae. Mol Cell Biol. 1987;7(10):3566-73 - PMID: 3316982 - PMCID: PMC368010 - DOI: 10.1128/mcb.7.10.3566
Whiteway M, Freedman R, Van Arsdell S, Szostak JW, Thorner J The yeast ARD1 gene product is required for repression of cryptic mating-type information at the HML locus. Mol Cell Biol. 1987;7(10):3713-22 - PMID: 3316986 - PMCID: PMC368027 - DOI: 10.1128/mcb.7.10.3713
Burke JM, Belfort M, Cech TR, Davies RW, Schweyen RJ, Shub DA, Szostak JW, Tabak HF Structural conventions for group I introns. Nucleic Acids Res. 1987;15(18):7217-21 - PMID: 3658691 - PMCID: PMC306243 - DOI: 10.1093/nar/15.18.7217
Murray AW, Szostak JW Chromosome segregation in mitosis and meiosis. Annu Rev Cell Biol. 1987;1:289-315 - PMID: 3916318 - DOI: 10.1146/annurev.cb.01.110185.001445
Dawson DS, Murray AW, Szostak JW An alternative pathway for meiotic chromosome segregation in yeast. Science. 1986;234(4777):713-7 - PMID: 3535068 - DOI: 10.1126/science.3535068
Murray AW, Szostak JW Construction and behavior of circularly permuted and telocentric chromosomes in Saccharomyces cerevisiae. Mol Cell Biol. 1986;6(9):3166-72 - PMID: 3537731 - PMCID: PMC367052 - DOI: 10.1128/mcb.6.9.3166
Szostak JW Enzymatic activity of the conserved core of a group I self-splicing intron. Nature. 1986;322(6074):83-6 - PMID: 3014350 - DOI: 10.1038/322083a0
Murray AW, Schultes NP, Szostak JW Chromosome length controls mitotic chromosome segregation in yeast. Cell. 1986;45(4):529-36 - PMID: 3518944 - DOI: 10.1016/0092-8674(86)90284-9
Whiteway M, Szostak JW The ARD1 gene of yeast functions in the switch between the mitotic cell cycle and alternative developmental pathways. Cell. 1985;43(2 Pt 1):483-92 - PMID: 3907857 - DOI: 10.1016/0092-8674(85)90178-3
Orr-Weaver TL, Szostak JW Fungal recombination. Microbiol Rev. 1985;49(1):33-58 - PMID: 3884994 - PMCID: PMC373016 - DOI: 10.1128/mr.49.1.33-58.1985
Ruby SW, Szostak JW Specific Saccharomyces cerevisiae genes are expressed in response to DNA-damaging agents. Mol Cell Biol. 1985;5(1):75-84 - PMID: 3920512 - PMCID: PMC366680 - DOI: 10.1128/mcb.5.1.75
Dunn B, Szauter P, Pardue ML, Szostak JW Transfer of yeast telomeres to linear plasmids by recombination. Cell. 1984;39(1):191-201 - PMID: 6091911 - DOI: 10.1016/0092-8674(84)90205-8
Shampay J, Szostak JW, Blackburn EH DNA sequences of telomeres maintained in yeast. Nature. 1984;310(5973):154-7 - PMID: 6330571 - DOI: 10.1038/310154a0
Sugawara N, Szostak JW Construction of specific chromosomal rearrangements in yeast. Methods Enzymol. 1983;101:269-78 - PMID: 6310329 - DOI: 10.1016/0076-6879(83)01020-4
Murray AW, Szostak JW Construction of artificial chromosomes in yeast. Nature. 1983;305(5931):189-93 - PMID: 6350893 - DOI: 10.1038/305189a0
Brown PA, Szostak JW Yeast vectors with negative selection. Methods Enzymol. 1983;101:278-90 - PMID: 6310330 - DOI: 10.1016/0076-6879(83)01021-6
Ruby SW, Szostak JW, Murray AW Cloning regulated yeast genes from a pool of lacZ fusions. Methods Enzymol. 1983;101:253-69 - PMID: 6310328 - DOI: 10.1016/0076-6879(83)01019-8
Orr-Weaver TL, Szostak JW, Rothstein RJ Genetic applications of yeast transformation with linear and gapped plasmids. Methods Enzymol. 1983;101:228-45 - PMID: 6310326 - DOI: 10.1016/0076-6879(83)01017-4
Szostak JW A rapid procedure for the construction of linear yeast plasmids. Methods Enzymol. 1983;101:245-52 - PMID: 6310327 - DOI: 10.1016/0076-6879(83)01018-6
Murray AW, Szostak JW Pedigree analysis of plasmid segregation in yeast. Cell. 1983;34(3):961-70 - PMID: 6354471 - DOI: 10.1016/0092-8674(83)90553-6
Sugawara N, Szostak JW Recombination between sequences in nonhomologous positions. Proc Natl Acad Sci U S A. 1983;80(18):5675-9 - PMID: 6351064 - PMCID: PMC384321 - DOI: 10.1073/pnas.80.18.5675
Szostak JW Replication and resolution of telomeres in yeast. Cold Spring Harb Symp Quant Biol. 1983;47 Pt 2:1187-94 - PMID: 6305577 - DOI: 10.1101/sqb.1983.047.01.134
Orr-Weaver TL, Szostak JW Yeast recombination: the association between double-strand gap repair and crossing-over. Proc Natl Acad Sci U S A. 1983;80(14):4417-21 - PMID: 6308623 - PMCID: PMC384049 - DOI: 10.1073/pnas.80.14.4417
Szostak JW, Orr-Weaver TL, Rothstein RJ, Stahl FW The double-strand-break repair model for recombination. Cell. 1983;33(1):25-35 - PMID: 6380756 - DOI: 10.1016/0092-8674(83)90331-8
Orr-Weaver TL, Szostak JW Multiple, tandem plasmid integration in Saccharomyces cerevisiae. Mol Cell Biol. 1983;3(4):747-9 - PMID: 6343844 - PMCID: PMC368590 - DOI: 10.1128/mcb.3.4.747
Walmsley RM, Szostak JW, Petes TD Is there left-handed DNA at the ends of yeast chromosomes?. Nature. 1983;302(5903):84-6 - PMID: 6338397 - DOI: 10.1038/302084a0
Szostak JW, Blackburn EH Cloning yeast telomeres on linear plasmid vectors. Cell. 1982;29(1):245-55 - PMID: 6286143 - DOI: 10.1016/0092-8674(82)90109-x
Orr-Weaver TL, Szostak JW, Rothstein RJ Yeast transformation: a model system for the study of recombination. Proc Natl Acad Sci U S A. 1981;78(10):6354-8 - PMID: 6273866 - PMCID: PMC349037 - DOI: 10.1073/pnas.78.10.6354
Stiles JI, Szostak JW, Young AT, Wu R, Consaul S, Sherman F DNA sequence of a mutation in the leader region of the yeast iso-1-cytochrome c mRNA. Cell. 1981;25(1):277-84 - PMID: 6268305 - DOI: 10.1016/0092-8674(81)90253-1
Szostak JW, Stiles JI, Tye BK, Chiu P, Sherman F, Wu R Hybridization with synthetic oligonucleotides. Methods Enzymol. 1980;68:419-28 - PMID: 161605 - DOI: 10.1016/0076-6879(79)68031-x
Szostak JW, Wu R Unequal crossing over in the ribosomal DNA of Saccharomyces cerevisiae. Nature. 1980;284(5755):426-30 - PMID: 6987539 - DOI: 10.1038/284426a0
Szostak JW, Wu R Insertion of a genetic marker into the ribosomal DNA of yeast. Plasmid. 1979;2(4):536-54 - PMID: 394173 - DOI: 10.1016/0147-619x(79)90053-2
Szostak JW, Stiles JI, Bahl CP, Wu R Specific binding of a synthetic oligodeoxyribonucleotide to yeast cytochrome c mRNA. Nature. 1977;265(5589):61-3 - PMID: 189200 - DOI: 10.1038/265061a0