Stuart, Lynda

Lyndastuart
Phone: 617-724-2890
Email:

Research

Lynda Stuart is a physician-scientist who received her medical degrees from the University of Cambridge and the University of London. She is a member of the Royal College of Physicians in the UK. She trained in internal medicine and nephrology in the UK, working in London, Oxford and Edinburgh.

Lynda received her PhD from the University of Edinburgh, where she worked under the supervision of Professor John Savill and Dr. Adam Lacy-Hulbert studying the mechanism and consequences of phagocytosis of apoptotic cells on dendritic cell function. Her postdoctoral training was in the laboratory of Alan Ezekowitz at Massachusetts General Hospital/Harvard Medical School, where she studied the role of phagocytic receptors and opsonins in modifying innate immunity responses. In addition, she developed a computational model of the phagosome based on proteomic analysis of this organelle. This model has been used to understand the cell biology of phagocytosis and the role of the phagosome in the context of the host-pathogen interaction.

Her research interest is in the role of innate immunity and phagocytosis both in the context of tissue remodeling and of host-pathogen interactions.

Selected Publications (from total of 42)

Articles

Mansour MK, Tam JM, Khan NS, Seward M, Davids PJ, Puranam S, Sokolovska A, Sykes DB, Dagher Z, Becker C, Tanne A, Reedy JL, Stuart LM, Vyas JM
Dectin-1 activation controls maturation of ?-1,3-glucan-containing phagosomes.
J Biol Chem. 2013;:ePub - PMID: 23609446
Stuart LM, Paquette N, Boyer L
Effector-triggered versus pattern-triggered immunity: how animals sense pathogens.
Nat Rev Immunol. 2013;13(3):199-206 - PMID: 23411798
Sokolovska A, Becker CE, Stuart LM
Measurement of Phagocytosis, Phagosome Acidification, and Intracellular Killing of Staphylococcus aureus.
Curr Protoc Immunol. 2012;Chapter 14:Unit14.30 - PMID: 23129153
Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria.
Cell. 2012;150(3):606-19 - PMID: 22819539
Luhachack LG, Visvikis O, Wollenberg AC, Lacy-Hulbert A, Stuart LM, Irazoqui JE
EGL-9 Controls C. elegans Host Defense Specificity through Prolyl Hydroxylation-Dependent and -Independent HIF-1 Pathways.
PLoS Pathog. 2012;8(7):e1002798 - PMID: 22792069 - PMCID: PMC3390412
Murad MH, Drake MT, Mullan RJ, Mauck KF, Stuart LM, Lane MA, Abu Elnour NO, Erwin PJ, Hazem A, Puhan MA, Li T, Montori VM
Clinical review. Comparative effectiveness of drug treatments to prevent fragility fractures: a systematic review and network meta-analysis.
J Clin Endocrinol Metab. 2012;97(6):1871-80 - PMID: 22466336
Lacy-Hulbert A, Stuart LM
Penetration Resistance: PKR's Other Talent.
Immunity. 2012;36(5):695-6 - PMID: 22633454
Drake MT, Murad MH, Mauck KF, Lane MA, Undavalli C, Elraiyah T, Stuart LM, Prasad C, Shahrour A, Mullan RJ, Hazem A, Erwin PJ, Montori VM
Clinical review. Risk factors for low bone mass-related fractures in men: a systematic review and meta-analysis.
J Clin Endocrinol Metab. 2012;97(6):1861-70 - PMID: 22466344
Perez B, Paquette N, Païdassi H, Zhai B, White K, Skvirsky R, Lacy-Hulbert A, Stuart LM
Apoptotic cells can deliver chemotherapeutics to engulfing macrophages and suppress inflammatory cytokine production.
J Biol Chem. 2012;287(19):16029-36 - PMID: 22433861 - PMCID: PMC3346138
van Gils JM, Derby MC, Fernandes LR, Ramkhelawon B, Ray TD, Rayner KJ, Parathath S, Distel E, Feig JL, Alvarez-Leite JI, Rayner AJ, McDonald TO, O'Brien KD, Stuart LM, Fisher EA, Lacy-Hulbert A, Moore KJ
The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques.
Nat Immunol. 2012;13(2):136-43 - PMID: 22231519 - PMCID: PMC3262880
Boyer L, Paquette N, Silverman N, Stuart LM
Bacterial effectors: learning on the fly.
Adv Exp Med Biol. 2011;710:29-36 - PMID: 22127883 - PMCID: PMC3427734
Boyer L, Magoc L, Dejardin S, Cappillino M, Paquette N, Hinault C, Charriere GM, Ip WK, Fracchia S, Hennessy E, Erturk-Hasdemir D, Reichhart JM, Silverman N, Lacy-Hulbert A, Stuart LM
Pathogen-derived effectors trigger protective immunity via activation of the Rac2 enzyme and the IMD or Rip kinase signaling pathway.
Immunity. 2011;35(4):536-49 - PMID: 22018470 - PMCID: PMC3258503
Païdassi H, Acharya M, Zhang A, Mukhopadhyay S, Kwon M, Chow C, Stuart LM, Savill J, Lacy-Hulbert A
Preferential expression of integrin avb8 promotes generation of regulatory T cells by mouse CD103+ dendritic cells.
Gastroenterology. 2011;141(5):1813-20 - PMID: 21745448 - PMCID: PMC3202651
Acharya M, Mukhopadhyay S, Païdassi H, Jamil T, Chow C, Kissler S, Stuart LM, Hynes RO, Lacy-Hulbert A
av Integrin expression by DCs is required for Th17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice.
J Clin Invest. 2010;120(12):4445-52 - PMID: 21099114 - PMCID: PMC2993596
Ip WK, Sokolovska A, Charriere GM, Boyer L, Dejardin S, Cappillino MP, Yantosca LM, Takahashi K, Moore KJ, Lacy-Hulbert A, Stuart LM
Phagocytosis and phagosome acidification are required for pathogen processing and MyD88-dependent responses to Staphylococcus aureus.
J Immunol. 2010;184(12):7071-81 - PMID: 20483752 - PMCID: PMC2935932
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