Stuart, Lynda

Lyndastuart
Phone: 617-724-2890
Email:

Research

Lynda Stuart is a physician-scientist who received her medical degrees from the University of Cambridge and the University of London. She is a member of the Royal College of Physicians in the UK. She trained in internal medicine and nephrology in the UK, working in London, Oxford and Edinburgh.

Lynda received her PhD from the University of Edinburgh, where she worked under the supervision of Professor John Savill and Dr. Adam Lacy-Hulbert studying the mechanism and consequences of phagocytosis of apoptotic cells on dendritic cell function. Her postdoctoral training was in the laboratory of Alan Ezekowitz at Massachusetts General Hospital/Harvard Medical School, where she studied the role of phagocytic receptors and opsonins in modifying innate immunity responses. In addition, she developed a computational model of the phagosome based on proteomic analysis of this organelle. This model has been used to understand the cell biology of phagocytosis and the role of the phagosome in the context of the host-pathogen interaction.

Her research interest is in the role of innate immunity and phagocytosis both in the context of tissue remodeling and of host-pathogen interactions.

Selected Publications (from total of 50)

Articles

Giles KM, Kalinowski FC, Candy PA, Epis MR, Zhang PM, Redfern AD, Stuart LM, Goodall GJ, Leedman PJ
Axl mediates acquired resistance of head and neck cancer cells to the epidermal growth factor receptor inhibitor erlotinib.
Mol Cancer Ther. 2013;12(11):2541-58 - PMID: 24026012
Wyatt KD, Stuart LM, Brito JP, Carranza Leon B, Domecq JP, Prutsky GJ, Egginton JS, Calvin AD, Shah ND, Murad MH, Montori VM
Out of Context: Clinical Practice Guidelines and Patients With Multiple Chronic Conditions: A Systematic Review.
Med Care. 2013;52 Suppl 3:S92-S100 - PMID: 23969592
Candy PA, Phillips MR, Redfern AD, Colley SM, Davidson JA, Stuart LM, Wood BA, Zeps N, Leedman PJ
Notch-induced transcription factors are predictive of survival and 5-fluorouracil response in colorectal cancer patients.
Br J Cancer. 2013;109(4):1023-30 - PMID: 23900217 - PMCID: PMC3749585
Karlsson EK, Harris JB, Tabrizi S, Rahman A, Shlyakhter I, Patterson N, O'Dushlaine C, Schaffner SF, Gupta S, Chowdhury F, Sheikh A, Shin OS, Ellis C, Becker CE, Stuart LM, Calderwood SB, Ryan ET, Qadri F, Sabeti PC, Larocque RC
Natural selection in a bangladeshi population from the cholera-endemic ganges river delta.
Sci Transl Med. 2013;5(192):192ra86 - PMID: 23825302
Sheedy FJ, Grebe A, Rayner KJ, Kalantari P, Ramkhelawon B, Carpenter SB, Becker CE, Ediriweera HN, Mullick AE, Golenbock DT, Stuart LM, Latz E, Fitzgerald KA, Moore KJ
CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation.
Nat Immunol. 2013;14(8):812-20 - PMID: 23812099 - PMCID: PMC3720827
Stuart LM, Boyer L
RhoGTPases - NODes for effector-triggered immunity in animals.
Cell Res. 2013;23(8):980-1 - PMID: 23689278 - PMCID: PMC3731559
Sokolovska A, Becker CE, Ip WK, Rathinam VA, Brudner M, Paquette N, Tanne A, Vanaja SK, Moore KJ, Fitzgerald KA, Lacy-Hulbert A, Stuart LM
Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function.
Nat Immunol. 2013;14(6):543-553 - PMID: 23644505 - PMCID: PMC3708594
Mansour MK, Tam JM, Khan NS, Seward M, Davids PJ, Puranam S, Sokolovska A, Sykes DB, Dagher Z, Becker C, Tanne A, Reedy JL, Stuart LM, Vyas JM
Dectin-1 activation controls maturation of ?-1,3-glucan-containing phagosomes.
J Biol Chem. 2013;288(22):16043-54 - PMID: 23609446 - PMCID: PMC3668760
Stuart LM, Paquette N, Boyer L
Effector-triggered versus pattern-triggered immunity: how animals sense pathogens.
Nat Rev Immunol. 2013;13(3):199-206 - PMID: 23411798
Sokolovska A, Becker CE, Stuart LM
Measurement of Phagocytosis, Phagosome Acidification, and Intracellular Killing of Staphylococcus aureus.
Curr Protoc Immunol. 2012;Chapter 14:Unit14.30 - PMID: 23129153
Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria.
Cell. 2012;150(3):606-19 - PMID: 22819539 - PMCID: PMC3660860
Luhachack LG, Visvikis O, Wollenberg AC, Lacy-Hulbert A, Stuart LM, Irazoqui JE
EGL-9 Controls C. elegans Host Defense Specificity through Prolyl Hydroxylation-Dependent and -Independent HIF-1 Pathways.
PLoS Pathog. 2012;8(7):e1002798 - PMID: 22792069 - PMCID: PMC3390412
Murad MH, Drake MT, Mullan RJ, Mauck KF, Stuart LM, Lane MA, Abu Elnour NO, Erwin PJ, Hazem A, Puhan MA, Li T, Montori VM
Clinical review. Comparative effectiveness of drug treatments to prevent fragility fractures: a systematic review and network meta-analysis.
J Clin Endocrinol Metab. 2012;97(6):1871-80 - PMID: 22466336
Lacy-Hulbert A, Stuart LM
Penetration Resistance: PKR's Other Talent.
Immunity. 2012;36(5):695-6 - PMID: 22633454
Drake MT, Murad MH, Mauck KF, Lane MA, Undavalli C, Elraiyah T, Stuart LM, Prasad C, Shahrour A, Mullan RJ, Hazem A, Erwin PJ, Montori VM
Clinical review. Risk factors for low bone mass-related fractures in men: a systematic review and meta-analysis.
J Clin Endocrinol Metab. 2012;97(6):1861-70 - PMID: 22466344
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