Seed, Brian

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Phone: 617-726-5975
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Research

Director, Center for Computational and Integrative Biology

Brian Seed is a Professor of Genetics at Harvard and Director of the Center for Computational and Integrative Biology at the Massachusetts General Hospital (MGH). He obtained his B.S. and Ph.D. degrees from the California Institute of Technology. Prof. Seed is the author of a number of publications on genetics and molecular biology with an emphasis on the development of methods and technology. His early efforts to develop of genetic selections for transiently expressed genes led to the identification of cDNAs encoding the majority of the then-recognized lineage antigens of the immune system. In addition he has made several contributions to the understanding of the mechanisms of T cell activation. His work on immunoglobulin fusion proteins led to the identification of several co-receptors and ligands and laid the basis for the development of several therapeutic fusion proteins. He co-founded several biotech companies including Connetics, Edge Biosystems, Phylos, Egret Pharma (Shanghai) Ltd. and Theracos, Inc. and has served on the advisory boards for Hoechst/Aventis, Medigene A.G., St. Jude Children’s Research Hospital, Phylos and New Leaf Ventures.

Brian Seed’s page at Harvard Biophysics

Brian Seed’s page at Harvard-MIT HST

Selected Publications (from total of 153)

Articles

Zhou GL, Beloiartsev A, Yu B, Baron DM, Zhou W, Niedra R, Lu N, Tainsh LT, Zapol WM, Seed B, Bloch KD
Deletion of the Murine Cytochrome P450 Cyp2j Locus by Fused BAC-Mediated Recombination Identifies a Role for Cyp2j in the Pulmonary Vascular Response to Hypoxia.
PLoS Genet. 2013;9(11):e1003950 - PMID: 24278032 - PMCID: PMC3836722
Freeman J, Kriston-Vizi J, Seed B, Ketteler R
A High-content Imaging Workflow to Study Grb2 Signaling Complexes by Expression Cloning.
J Vis Exp. 2012;(68):ePub - PMID: 23150065 - PMCID: PMC3499067
Cho JL, Roche MI, Sandall B, Brass AL, Seed B, Xavier RJ, Medoff BD
Enhanced Tim3 Activity Improves Survival after Influenza Infection.
J Immunol. 2012;189(6):2879-89 - PMID: 22875804 - PMCID: PMC3436990
Zhou L, Kawate T, Liu X, Kim YB, Zhao Y, Feng G, Banerji J, Nash H, Whitehurst C, Jindal S, Siddiqui A, Seed B, Wolfe JL
STAT6 phosphorylation inhibitors block eotaxin-3 secretion in bronchial epithelial cells.
Bioorg Med Chem. 2011;20(2):750-8 - PMID: 22217933
Wang X, Spandidos A, Wang H, Seed B
PrimerBank: a PCR primer database for quantitative gene expression analysis, 2012 update.
Nucleic Acids Res. 2011;40(Database issue):D1144-9 - PMID: 22086960 - PMCID: PMC3245149
Lindquist S, Karitkina D, Langnaese K, Posevitz-Fejfar A, Schraven B, Xavier R, Seed B, Lindquist JA
Phosphoprotein associated with glycosphingolipid-enriched microdomains differentially modulates SRC kinase activity in brain maturation.
PLoS One. 2011;6(9):e23978 - PMID: 21915273 - PMCID: PMC3167820
Xu B, Feng Y, Cheng H, Song Y, Lv B, Wu Y, Wang C, Li S, Xu M, Du J, Peng K, Dong J, Zhang W, Zhang T, Zhu L, Ding H, Sheng Z, Welihinda A, Roberge JY, Seed B, Chen Y
C-aryl glucosides substituted at the 4'-position as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.
Bioorg Med Chem Lett. 2011;21(15):4465-70 - PMID: 21737266
Zhang W, Welihinda A, Mechanic J, Ding H, Zhu L, Lu Y, Deng Z, Sheng Z, Lv B, Chen Y, Roberge JY, Seed B, Wang YX
EGT1442, a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA(1c) levels in db/db mice and prolongs the survival of stroke-prone rats.
Pharmacol Res. 2011;63(4):284-93 - PMID: 21215314
Kim H, Seed B
The transcription factor MafB antagonizes antiviral responses by blocking recruitment of coactivators to the transcription factor IRF3.
Nat Immunol. 2010;11(8):743-50 - PMID: 20581830 - PMCID: PMC3050627
Mashima R, Honda K, Yang Y, Morita Y, Inoue A, Arimura S, Nishina H, Ema H, Nakauchi H, Seed B, Oda H, Yamanashi Y
Mice lacking Dok-1, Dok-2, and Dok-3 succumb to aggressive histiocytic sarcoma.
Lab Invest. 2010;90(9):1357-64 - PMID: 20548287
Lv B, Feng Y, Dong J, Xu M, Xu B, Zhang W, Sheng Z, Welihinda A, Seed B, Chen Y
Conformationally constrained spiro C-arylglucosides as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.
ChemMedChem. 2010;5(6):827-31 - PMID: 20414917
Westerberg LS, Meelu P, Baptista M, Eston MA, Adamovich DA, Cotta-de-Almeida V, Seed B, Rosen MK, Vandenberghe P, Thrasher AJ, Klein C, Alt FW, Snapper SB
Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes.
J Exp Med. 2010;207(6):1145-52 - PMID: 20513746 - PMCID: PMC2882832
Xu B, Feng Y, Lv B, Xu G, Zhang L, Du J, Peng K, Xu M, Dong J, Zhang W, Zhang T, Zhu L, Ding H, Sheng Z, Welihinda A, Seed B, Chen Y
ortho-Substituted C-aryl glucosides as highly potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.
Bioorg Med Chem. 2010;18(12):4422-32 - PMID: 20576578
Ketteler R, Tomov V, Neunkirchner A, Xie Q, Pickl WF, Seed B
Host-encoded reporters for the detection and purification of multiple enveloped viruses.
J Virol Methods. 2010;167(2):178-85 - PMID: 20399809 - PMCID: PMC2916077
Kueng HJ, Manta C, Haiderer D, Leb VM, Schmetterer KG, Neunkirchner A, Byrne RA, Scheinecker C, Steinberger P, Seed B, Pickl WF
Fluorosomes: a convenient new reagent to detect and block multivalent and complex receptor-ligand interactions.
FASEB J. 2010;24(5):1572-82 - PMID: 20056716 - PMCID: PMC2879947
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