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  • Kim N, Dempsey CM, Kuan CJ, Zoval JV, O'Rourke E, Ruvkun G, Madou MJ, Sze JY Gravity force transduced by the MEC-4/MEC-10 DEG/ENaC channel modulates DAF-16/FoxO activity in Caenorhabditis elegans. Genetics. 2007;177(2):835-45 - PMID: 17720915 - PMCID: PMC2034647 - DOI: 10.1534/genetics.107.076901

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  • Ruvkun G Clarifications on miRNA and cancer. Science. 2006;311(5757):36-7 - PMID: 16400132 - DOI: 10.1126/science.311.5757.36d

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  • Sandoval GM, Duerr JS, Hodgkin J, Rand JB, Ruvkun G A genetic interaction between the vesicular acetylcholine transporter VAChT/UNC-17 and synaptobrevin/SNB-1 in C. elegans. Nat Neurosci. 2006;9(5):599-601 - PMID: 16604067 - DOI: 10.1038/nn1685

  • Hu PJ, Xu J, Ruvkun G Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling. PLoS Genet. 2006;2(7):e99 - PMID: 16839187 - PMCID: PMC1487177 - DOI: 10.1371/journal.pgen.0020099

  • Hayes GD, Frand AR, Ruvkun G The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25. Development. 2006;133(23):4631-41 - PMID: 17065234 - DOI: 10.1242/dev.02655

  • Kim JK, Gabel HW, Kamath RS, Tewari M, Pasquinelli A, Rual JF, Kennedy S, Dybbs M, Bertin N, Kaplan JM, Vidal M, Ruvkun G Functional genomic analysis of RNA interference in C. elegans. Science. 2005;308(5725):1164-7 - PMID: 15790806 - DOI: 10.1126/science.1109267

  • Efimenko E, Bubb K, Mak HY, Holzman T, Leroux MR, Ruvkun G, Thomas JH, Swoboda P Analysis of xbx genes in C. elegans. Development. 2005;132(8):1923-34 - PMID: 15790967 - DOI: 10.1242/dev.01775

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  • Sieburth D, Ch'ng Q, Dybbs M, Tavazoie M, Kennedy S, Wang D, Dupuy D, Rual JF, Hill DE, Vidal M, Ruvkun G, Kaplan JM Systematic analysis of genes required for synapse structure and function. Nature. 2005;436(7050):510-7 - PMID: 16049479 - DOI: 10.1038/nature03809

  • Wang D, Kennedy S, Conte D, Kim JK, Gabel HW, Kamath RS, Mello CC, Ruvkun G Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants. Nature. 2005;436(7050):593-7 - PMID: 16049496 - DOI: 10.1038/nature04010

  • Wang D, Ruvkun G Regulation of Caenorhabditis elegans RNA interference by the daf-2 insulin stress and longevity signaling pathway. Cold Spring Harb Symp Quant Biol. 2005;69:429-31 - PMID: 16117677 - DOI: 10.1101/sqb.2004.69.429

  • Frand AR, Russel S, Ruvkun G Functional genomic analysis of C. elegans molting. PLoS Biol. 2005;3(10):e312 - PMID: 16122351 - PMCID: PMC1233573 - DOI: 10.1371/journal.pbio.0030312

  • Kennedy S, Wang D, Ruvkun G A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans. Nature. 2004;427(6975):645-9 - PMID: 14961122 - DOI: 10.1038/nature02302

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  • Mak HY, Ruvkun G Intercellular signaling of reproductive development by the C. elegans DAF-9 cytochrome P450. Development. 2004;131(8):1777-86 - PMID: 15084462 - DOI: 10.1242/dev.01069

  • Mansfield JH, Harfe BD, Nissen R, Obenauer J, Srineel J, Chaudhuri A, Farzan-Kashani R, Zuker M, Pasquinelli AE, Ruvkun G, Sharp PA, Tabin CJ, McManus MT MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Nat Genet. 2004;36(10):1079-83 - PMID: 15361871 - DOI: 10.1038/ng1421

  • Ashrafi K, Chang FY, Watts JL, Fraser AG, Kamath RS, Ahringer J, Ruvkun G Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Nature. 2003;421(6920):268-72 - PMID: 12529643 - DOI: 10.1038/nature01279

  • Ambros V, Bartel B, Bartel DP, Burge CB, Carrington JC, Chen X, Dreyfuss G, Eddy SR, Griffiths-Jones S, Marshall M, Matzke M, Ruvkun G, Tuschl T A uniform system for microRNA annotation. RNA. 2003;9(3):277-9 - PMID: 12592000 - PMCID: PMC1370393 - DOI: 10.1261/rna.2183803

  • Li W, Kennedy SG, Ruvkun G daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway. Genes Dev. 2003;17(7):844-58 - PMID: 12654727 - PMCID: PMC196030 - DOI: 10.1101/gad.1066503

  • Lee SS, Kennedy S, Tolonen AC, Ruvkun G DAF-16 target genes that control C. elegans life-span and metabolism. Science. 2003;300(5619):644-7 - PMID: 12690206 - DOI: 10.1126/science.1083614

  • Grad Y, Aach J, Hayes GD, Reinhart BJ, Church GM, Ruvkun G, Kim J Computational and experimental identification of C. elegans microRNAs. Mol Cell. 2003;11(5):1253-63 - PMID: 12769849 - DOI: 10.1016/s1097-2765(03)00153-9

  • Aspöck G, Ruvkun G, Bürglin TR The Caenorhabditis elegans ems class homeobox gene ceh-2 is required for M3 pharynx motoneuron function. Development. 2003;130(15):3369-78 - PMID: 12810585 - DOI: 10.1242/dev.00551

  • Bashirullah A, Pasquinelli AE, Kiger AA, Perrimon N, Ruvkun G, Thummel CS Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis. Dev Biol. 2003;259(1):1-8 - PMID: 12812783 - DOI: 10.1016/s0012-1606(03)00063-0

  • Garsin DA, Villanueva JM, Begun J, Kim DH, Sifri CD, Calderwood SB, Ruvkun G, Ausubel FM Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens. Science. 2003;300(5627):1921 - PMID: 12817143 - DOI: 10.1126/science.1080147

  • Pasquinelli AE, McCoy A, Jiménez E, Saló E, Ruvkun G, Martindale MQ, Baguñà J Expression of the 22 nucleotide let-7 heterochronic RNA throughout the Metazoa: a role in life history evolution?. Evol Dev. 2003;5(4):372-8 - PMID: 12823453 - DOI: 10.1046/j.1525-142x.2003.03044.x

  • Sze JY, Ruvkun G Activity of the Caenorhabditis elegans UNC-86 POU transcription factor modulates olfactory sensitivity. Proc Natl Acad Sci U S A. 2003;100(16):9560-5 - PMID: 12883006 - PMCID: PMC170957 - DOI: 10.1073/pnas.1530752100

  • Ruvinsky I, Ruvkun G Functional tests of enhancer conservation between distantly related species. Development. 2003;130(21):5133-42 - PMID: 12944426 - DOI: 10.1242/dev.00711

  • Komaroff AL, Ruvkun G Unraveling the secrets of the cell. Newsweek. 2003;142(23):96 - PMID: 14712576

  • Garsin DA, Villanueva JM, Begun J, Kim DH, Sifri CD, Calderwood SB, Ruvkun G, Ausubel FM Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens. Science. 2003;300(5627):1921 - PMID: 12817143 - DOI: 10.1126/science.1080147

  • Lee SS, Ruvkun G Longevity: don't hold your breath. Nature. 2002;418(6895):287-8 - PMID: 12124610 - DOI: 10.1038/418287a

  • Sze JY, Zhang S, Li J, Ruvkun G The C. elegans POU-domain transcription factor UNC-86 regulates the tph-1 tryptophan hydroxylase gene and neurite outgrowth in specific serotonergic neurons. Development. 2002;129(16):3901-11 - PMID: 12135927 - DOI: 10.1242/dev.129.16.3901

  • Pasquinelli AE, Ruvkun G Control of developmental timing by micrornas and their targets. Annu Rev Cell Dev Biol. 2002;18:495-513 - PMID: 12142272 - DOI: 10.1146/annurev.cellbio.18.012502.105832

  • Wolkow CA, Muñoz MJ, Riddle DL, Ruvkun G Insulin receptor substrate and p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway. J Biol Chem. 2002;277(51):49591-7 - PMID: 12393910 - DOI: 10.1074/jbc.M207866200

  • Reinhart BJ, Ruvkun G Isoform-specific mutations in the Caenorhabditis elegans heterochronic gene lin-14 affect stage-specific patterning. Genetics. 2001;157(1):199-209 - PMID: 11139502 - PMCID: PMC1461488 - DOI: 10.1093/genetics/157.1.199

  • Bürglin TR, Ruvkun G Regulation of ectodermal and excretory function by the C. elegans POU homeobox gene ceh-6. Development. 2001;128(5):779-90 - PMID: 11171402 - DOI: 10.1242/dev.128.5.779

  • Pierce SB, Costa M, Wisotzkey R, Devadhar S, Homburger SA, Buchman AR, Ferguson KC, Heller J, Platt DM, Pasquinelli AA, Liu LX, Doberstein SK, Ruvkun G Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family. Genes Dev. 2001;15(6):672-86 - PMID: 11274053 - PMCID: PMC312654 - DOI: 10.1101/gad.867301

  • Grishok A, Pasquinelli AE, Conte D, Li N, Parrish S, Ha I, Baillie DL, Fire A, Ruvkun G, Mello CC Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell. 2001;106(1):23-34 - PMID: 11461699 - DOI: 10.1016/s0092-8674(01)00431-7

  • Ruvkun G Molecular biology. Glimpses of a tiny RNA world. Science. 2001;294(5543):797-9 - PMID: 11679654 - DOI: 10.1126/science.1066315

  • Finch CE, Ruvkun G The genetics of aging. Annu Rev Genomics Hum Genet. 2001;2:435-62 - PMID: 11701657 - DOI: 10.1146/annurev.genom.2.1.435

  • Lee RY, Hench J, Ruvkun G Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway. Curr Biol. 2001;11(24):1950-7 - PMID: 11747821 - DOI: 10.1016/s0960-9822(01)00595-4

  • Tissenbaum HA, Hawdon J, Perregaux M, Hotez P, Guarente L, Ruvkun G A common muscarinic pathway for diapause recovery in the distantly related nematode species Caenorhabditis elegans and Ancylostoma caninum. Proc Natl Acad Sci U S A. 2000;97(1):460-5 - PMID: 10618440 - PMCID: PMC26685 - DOI: 10.1073/pnas.97.1.460

  • Sze JY, Victor M, Loer C, Shi Y, Ruvkun G Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant. Nature. 2000;403(6769):560-4 - PMID: 10676966 - DOI: 10.1038/35000609

  • Reinhart BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC, Rougvie AE, Horvitz HR, Ruvkun G The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature. 2000;403(6772):901-6 - PMID: 10706289 - DOI: 10.1038/35002607

  • Slack FJ, Basson M, Liu Z, Ambros V, Horvitz HR, Ruvkun G The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor. Mol Cell. 2000;5(4):659-69 - PMID: 10882102 - DOI: 10.1016/s1097-2765(00)80245-2

  • Nasrin N, Ogg S, Cahill CM, Biggs W, Nui S, Dore J, Calvo D, Shi Y, Ruvkun G, Alexander-Bridges MC DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells. Proc Natl Acad Sci U S A. 2000;97(19):10412-7 - PMID: 10973497 - PMCID: PMC27038 - DOI: 10.1073/pnas.190326997

  • Wolkow CA, Kimura KD, Lee MS, Ruvkun G Regulation of C. elegans life-span by insulinlike signaling in the nervous system. Science. 2000;290(5489):147-50 - PMID: 11021802 - DOI: 10.1126/science.290.5489.147

  • Pasquinelli AE, Reinhart BJ, Slack F, Martindale MQ, Kuroda MI, Maller B, Hayward DC, Ball EE, Degnan B, Müller P, Spring J, Srinivasan A, Fishman M, Finnerty J, Corbo J, Levine M, Leahy P, Davidson E, Ruvkun G Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature. 2000;408(6808):86-9 - PMID: 11081512 - DOI: 10.1038/35040556

  • Kagoshima H, Sommer R, Reinhart BJ, Cassata G, Ruvkun G, Bürglin TR Graded expression of ceh-14 reporters in the hypodermis is induced by a gonadal signal. Dev Genes Evol. 2000;210(11):564-9 - PMID: 11180807 - DOI: 10.1007/s004270000099

  • Hobert O, Moerman DG, Clark KA, Beckerle MC, Ruvkun G A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans. J Cell Biol. 1999;144(1):45-57 - PMID: 9885243 - PMCID: PMC2148118 - DOI: 10.1083/jcb.144.1.45

  • Hobert O, Tessmar K, Ruvkun G The Caenorhabditis elegans lim-6 LIM homeobox gene regulates neurite outgrowth and function of particular GABAergic neurons. Development. 1999;126(7):1547-62 - PMID: 10068647 - DOI: 10.1242/dev.126.7.1547

  • Hobert O, Ruvkun G Pax genes in Caenorhabditis elegans: a new twist. Trends Genet. 1999;15(6):214-6 - PMID: 10354580 - DOI: 10.1016/s0168-9525(99)01731-x

  • Paradis S, Ailion M, Toker A, Thomas JH, Ruvkun G A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans. Genes Dev. 1999;13(11):1438-52 - PMID: 10364160 - PMCID: PMC316759 - DOI: 10.1101/gad.13.11.1438

  • Sagasti A, Hobert O, Troemel ER, Ruvkun G, Bargmann CI Alternative olfactory neuron fates are specified by the LIM homeobox gene lim-4. Genes Dev. 1999;13(14):1794-806 - PMID: 10421632 - PMCID: PMC316880 - DOI: 10.1101/gad.13.14.1794

  • Davidson EH, Ruvkun G Themes from a NASA workshop on gene regulatory processes in development and evolution. J Exp Zool. 1999;285(2):104-15 - PMID: 10440721 - DOI: 10.1002/(sici)1097-010x(19990815)285:2<104::aid-jez2>3.0.co;2-z

  • Slack F, Ruvkun G Temporal pattern formation by heterochronic genes. Annu Rev Genet. 1998;31:611-34 - PMID: 9442909 - DOI: 10.1146/annurev.genet.31.1.611

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  • Hobert O, D'Alberti T, Liu Y, Ruvkun G Control of neural development and function in a thermoregulatory network by the LIM homeobox gene lin-11. J Neurosci. 1998;18(6):2084-96 - PMID: 9482795 - PMCID: PMC6792926 - DOI: 10.1523/JNEUROSCI.18-06-02084.1998

  • Paradis S, Ruvkun G Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes Dev. 1998;12(16):2488-98 - PMID: 9716402 - PMCID: PMC317081 - DOI: 10.1101/gad.12.16.2488

  • Guarente L, Ruvkun G, Amasino R Aging, life span, and senescence. Proc Natl Acad Sci U S A. 1998;95(19):11034-6 - PMID: 9736682 - PMCID: PMC33892 - DOI: 10.1073/pnas.95.19.11034

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  • Ogg S, Ruvkun G The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway. Mol Cell. 1998;2(6):887-93 - PMID: 9885576 - DOI: 10.1016/s1097-2765(00)80303-2

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  • Sluder AE, Lindblom T, Ruvkun G The Caenorhabditis elegans orphan nuclear hormone receptor gene nhr-2 functions in early embryonic development. Dev Biol. 1997;184(2):303-19 - PMID: 9133437 - DOI: 10.1006/dbio.1997.8544

  • Hobert O, Mori I, Yamashita Y, Honda H, Ohshima Y, Liu Y, Ruvkun G Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 LIM homeobox gene. Neuron. 1997;19(2):345-57 - PMID: 9292724 - DOI: 10.1016/s0896-6273(00)80944-7

  • Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science. 1997;277(5328):942-6 - PMID: 9252323 - DOI: 10.1126/science.277.5328.942

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  • Baumeister R, Liu Y, Ruvkun G Lineage-specific regulators couple cell lineage asymmetry to the transcription of the Caenorhabditis elegans POU gene unc-86 during neurogenesis. Genes Dev. 1996;10(11):1395-410 - PMID: 8647436 - DOI: 10.1101/gad.10.11.1395

  • Barnes TM, Jin Y, Horvitz HR, Ruvkun G, Hekimi S The Caenorhabditis elegans behavioral gene unc-24 encodes a novel bipartite protein similar to both erythrocyte band 7.2 (stomatin) and nonspecific lipid transfer protein. J Neurochem. 1996;67(1):46-57 - PMID: 8667025 - DOI: 10.1046/j.1471-4159.1996.67010046.x

  • Morris JZ, Tissenbaum HA, Ruvkun G A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature. 1996;382(6591):536-9 - PMID: 8700226 - DOI: 10.1038/382536a0

  • Ha I, Wightman B, Ruvkun G A bulged lin-4/lin-14 RNA duplex is sufficient for Caenorhabditis elegans lin-14 temporal gradient formation. Genes Dev. 1996;10(23):3041-50 - PMID: 8957004 - DOI: 10.1101/gad.10.23.3041

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  • Greenstein D, Hird S, Plasterk RH, Andachi Y, Kohara Y, Wang B, Finney M, Ruvkun G Targeted mutations in the Caenorhabditis elegans POU homeo box gene ceh-18 cause defects in oocyte cell cycle arrest, gonad migration, and epidermal differentiation. Genes Dev. 1994;8(16):1935-48 - PMID: 7958868 - DOI: 10.1101/gad.8.16.1935

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  • Ruvkun G, Wightman B, Bürglin T, Arasu P Dominant gain-of-function mutations that lead to misregulation of the C. elegans heterochronic gene lin-14, and the evolutionary implications of dominant mutations in pattern-formation genes. Dev Suppl. 1992;1:47-54 - PMID: 1742500

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  • Xue D, Finney M, Ruvkun G, Chalfie M Regulation of the mec-3 gene by the C.elegans homeoproteins UNC-86 and MEC-3. EMBO J. 1992;11(13):4969-79 - PMID: 1361171 - PMCID: PMC556975 - DOI: 10.1002/j.1460-2075.1992.tb05604.x

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  • Bürglin TR, Ruvkun G, Coulson A, Hawkins NC, McGhee JD, Schaller D, Wittmann C, Müller F, Waterston RH Nematode homeobox cluster. Nature. 1991;351(6329):703 - PMID: 1676487 - DOI: 10.1038/351703a0

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  • Ruvkun G, Gilbert W, Horvitz HR Detection of mutations and DNA polymorphisms using whole genome Southern Cross hybridization. Nucleic Acids Res. 1990;18(4):809-15 - PMID: 2315039 - PMCID: PMC330331 - DOI: 10.1093/nar/18.4.809

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  • Ruvkun G, Ambros V, Coulson A, Waterston R, Sulston J, Horvitz HR Molecular genetics of the Caenorhabditis elegans heterochronic gene lin-14. Genetics. 1989;121(3):501-16 - PMID: 2565854 - PMCID: PMC1203636 - DOI: 10.1093/genetics/121.3.501

  • Ruvkun G, Giusto J The Caenorhabditis elegans heterochronic gene lin-14 encodes a nuclear protein that forms a temporal developmental switch. Nature. 1989;338(6213):313-9 - PMID: 2922060 - DOI: 10.1038/338313a0

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  • Herr W, Sturm RA, Clerc RG, Corcoran LM, Baltimore D, Sharp PA, Ingraham HA, Rosenfeld MG, Finney M, Ruvkun G The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products. Genes Dev. 1988;2(12A):1513-6 - PMID: 3215510 - DOI: 10.1101/gad.2.12a.1513

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  • Ruvkun GB, Long SR, Meade HM, van den Bos RC, Ausubel FM ISRm1: A Rhizobium meliloti insertion sequence that transposes preferentially into nitrogen fixation genes. J Mol Appl Genet. 1983;1(5):405-18 - PMID: 6296251

  • Meade HM, Long SR, Ruvkun GB, Brown SE, Ausubel FM Physical and genetic characterization of symbiotic and auxotrophic mutants of Rhizobium meliloti induced by transposon Tn5 mutagenesis. J Bacteriol. 1982;149(1):114-22 - PMID: 6274841 - PMCID: PMC216598 - DOI: 10.1128/JB.149.1.114-122.1982

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  • Ruvkun GB, Sundaresan V, Ausubel FM Specific protection of nucleotides in the lac operator from DMS methylation and DNase I nicking by crude bacterial cell extracts. Gene. 1982;18(3):247-55 - PMID: 6290328 - DOI: 10.1016/0378-1119(82)90162-7

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  • Ruvkun GB, Ausubel FM A general method for site-directed mutagenesis in prokaryotes. Nature. 1981;289(5793):85-8 - PMID: 6256652 - DOI: 10.1038/289085a0

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  • Ruvkun GB, Ausubel FM Interspecies homology of nitrogenase genes. Proc Natl Acad Sci U S A. 1980;77(1):191-5 - PMID: 6987649 - PMCID: PMC348234 - DOI: 10.1073/pnas.77.1.191

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