• Warnhoff K, Bhattacharya S, Snoozy J, Breen PC, Ruvkun G Hypoxia-inducible factor induces cysteine dioxygenase and promotes cysteine homeostasis in Caenorhabditis elegans. Elife. 2024;12:ePub - PMID: 38349720 - PMCID: PMC10942545 - DOI: 10.7554/eLife.89173

  • Meisel JD, Miranda M, Skinner OS, Wiesenthal PP, Wellner SM, Jourdain AA, Ruvkun G, Mootha VK Hypoxia and intra-complex genetic suppressors rescue complex I mutants by a shared mechanism. Cell. 2024;187(3):659-675.e18 - PMID: 38215760 - PMCID: PMC10919891 - DOI: 10.1016/j.cell.2023.12.010

  • Warnhoff K, Snoozy J, Breen PC, Ruvkun G Hypoxia-inducible factor promotes cysteine homeostasis in Caenorhabditis elegans. bioRxiv. 2023;:ePub - PMID: 37205365 - PMCID: PMC10187278 - DOI: 10.1101/2023.05.04.538701

  • Mao K, Breen P, Ruvkun G The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways. Proc Natl Acad Sci U S A. 2022;119(49):e2215966119 - PMID: 36445965 - PMCID: PMC9894117 - DOI: 10.1073/pnas.2215966119

  • Ruvkun G, Lehrbach N Regulation and Functions of the ER-Associated Nrf1 Transcription Factor. Cold Spring Harb Perspect Biol. 2022;15(1):ePub - PMID: 35940907 - PMCID: PMC9808582 - DOI: 10.1101/cshperspect.a041266

  • Snoozy J, Breen PC, Ruvkun G, Warnhoff K moc-6/MOCS2A is necessary for molybdenum cofactor synthesis in C. elegans. MicroPubl Biol. 2022;2022:ePub - PMID: 35224462 - PMCID: PMC8864482 - DOI: 10.17912/micropub.biology.000531

  • Charlesworth AG, Seroussi U, Lehrbach NJ, Renaud MS, Sundby AE, Molnar RI, Lao RX, Willis AR, Woock JR, Aber MJ, Diao AJ, Reinke AW, Ruvkun G, Claycomb JM Two isoforms of the essential C. elegans Argonaute CSR-1 differentially regulate sperm and oocyte fertility. Nucleic Acids Res. 2021;49(15):8836-8865 - PMID: 34329465 - PMCID: PMC8421154 - DOI: 10.1093/nar/gkab619

  • Warnhoff K, Hercher TW, Mendel RR, Ruvkun G Protein-bound molybdenum cofactor is bioavailable and rescues molybdenum cofactor-deficient C. elegans. Genes Dev. 2021;35(3-4):212-217 - PMID: 33446569 - PMCID: PMC7849362 - DOI: 10.1101/gad.345579.120

  • Mao K, Breen P, Ruvkun G Mitochondrial dysfunction induces RNA interference in C. elegans through a pathway homologous to the mammalian RIG-I antiviral response. PLoS Biol. 2020;18(12):e3000996 - PMID: 33264285 - PMCID: PMC7735679 - DOI: 10.1371/journal.pbio.3000996

  • Carr CE, Bryan NC, Saboda KN, Bhattaru SA, Ruvkun G, Zuber MT Nanopore sequencing at Mars, Europa, and microgravity conditions. NPJ Microgravity. 2020;6(1):24 - PMID: 34489469 - DOI: 10.1038/s41526-020-00113-9

  • Wei W, Ruvkun G Lysosomal activity regulates Caenorhabditis elegans mitochondrial dynamics through vitamin B12 metabolism. Proc Natl Acad Sci U S A. 2020;117(33):19970-19981 - PMID: 32737159 - PMCID: PMC7443905 - DOI: 10.1073/pnas.2008021117

  • Fischer SEJ, Ruvkun G Caenorhabditis elegans ADAR editing and the ERI-6/7/MOV10 RNAi pathway silence endogenous viral elements and LTR retrotransposons. Proc Natl Acad Sci U S A. 2020;117(11):5987-5996 - PMID: 32123111 - PMCID: PMC7084138 - DOI: 10.1073/pnas.1919028117

  • Govindan JA, Jayamani E, Ruvkun G ROS-based lethality of Caenorhabditis elegans mitochondrial electron transport mutants grown on Escherichia coli siderophore iron release mutants. Proc Natl Acad Sci U S A. 2019;116(43):21651-21658 - PMID: 31591219 - PMCID: PMC6815122 - DOI: 10.1073/pnas.1912628116

  • Mojarro A, Hachey J, Bailey R, Brown M, Doebler R, Ruvkun G, Zuber MT, Carr CE Nucleic Acid Extraction and Sequencing from Low-Biomass Synthetic Mars Analog Soils for In Situ Life Detection. Astrobiology. 2019;19(9):1139-1152 - PMID: 31204862 - PMCID: PMC6708270 - DOI: 10.1089/ast.2018.1929

  • Armakola M, Ruvkun G Regulation of Caenorhabditis elegans neuronal polarity by heterochronic genes. Proc Natl Acad Sci U S A. 2019;116(25):12327-12336 - PMID: 31164416 - PMCID: PMC6589651 - DOI: 10.1073/pnas.1820928116

  • Ast T, Meisel JD, Patra S, Wang H, Grange RMH, Kim SH, Calvo SE, Orefice LL, Nagashima F, Ichinose F, Zapol WM, Ruvkun G, Barondeau DP, Mootha VK Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis. Cell. 2019;177(6):1507-1521.e16 - PMID: 31031004 - PMCID: PMC6911770 - DOI: 10.1016/j.cell.2019.03.045

  • Lehrbach NJ, Ruvkun G Endoplasmic reticulum-associated SKN-1A/Nrf1 mediates a cytoplasmic unfolded protein response and promotes longevity. Elife. 2019;8:ePub - PMID: 30973820 - PMCID: PMC6459674 - DOI: 10.7554/eLife.44425

  • Lehrbach NJ, Breen PC, Ruvkun G Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression. Cell. 2019;177(3):737-750.e15 - PMID: 31002798 - PMCID: PMC6574124 - DOI: 10.1016/j.cell.2019.03.035

  • Warnhoff K, Ruvkun G Molybdenum cofactor transfer from bacteria to nematode mediates sulfite detoxification. Nat Chem Biol. 2019;15(5):480-488 - PMID: 30911177 - PMCID: PMC6470025 - DOI: 10.1038/s41589-019-0249-y

  • Mao K, Ji F, Breen P, Sewell A, Han M, Sadreyev R, Ruvkun G Mitochondrial Dysfunction in C. elegans Activates Mitochondrial Relocalization and Nuclear Hormone Receptor-Dependent Detoxification Genes. Cell Metab. 2019;29(5):1182-1191.e4 - PMID: 30799287 - PMCID: PMC6506380 - DOI: 10.1016/j.cmet.2019.01.022

  • Kniazeva M, Ruvkun G Rhizobium induces DNA damage in Caenorhabditis elegans intestinal cells. Proc Natl Acad Sci U S A. 2019;116(9):3784-3792 - PMID: 30808764 - PMCID: PMC6397575 - DOI: 10.1073/pnas.1815656116

  • Lin XX, Sen I, Janssens GE, Zhou X, Fonslow BR, Edgar D, Stroustrup N, Swoboda P, Yates JR, Ruvkun G, Riedel CG DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity. Nat Commun. 2018;9(1):4400 - PMID: 30353013 - PMCID: PMC6199276 - DOI: 10.1038/s41467-018-06624-0

  • Tillman EJ, Richardson CE, Cattie DJ, Reddy KC, Lehrbach NJ, Droste R, Ruvkun G, Kim DH Endoplasmic Reticulum Homeostasis Is Modulated by the Forkhead Transcription Factor FKH-9 During Infection of Caenorhabditis elegans. Genetics. 2018;210(4):1329-1337 - PMID: 30287474 - PMCID: PMC6283152 - DOI: 10.1534/genetics.118.301450

  • Carr CE, Bryan NC, Saboda KN, Bhattaru SA, Ruvkun G, Zuber MT Acceleration profiles and processing methods for parabolic flight. NPJ Microgravity. 2018;4:14 - PMID: 30109261 - PMCID: PMC6081456 - DOI: 10.1038/s41526-018-0050-3

  • Ambros V, Ruvkun G Recent Molecular Genetic Explorations of Caenorhabditis elegans MicroRNAs. Genetics. 2018;209(3):651-673 - PMID: 29967059 - PMCID: PMC6028246 - DOI: 10.1534/genetics.118.300291

  • Pontefract A, Hachey J, Zuber MT, Ruvkun G, Carr CE Sequencing nothing: Exploring failure modes of nanopore sensing and implications for life detection. Life Sci Space Res (Amst). 2018;18:80-86 - PMID: 30100151 - DOI: 10.1016/j.lssr.2018.05.004

  • Newman MA, Ji F, Fischer SEJ, Anselmo A, Sadreyev RI, Ruvkun G The surveillance of pre-mRNA splicing is an early step in C. elegans RNAi of endogenous genes. Genes Dev. 2018;32(9-10):670-681 - PMID: 29739806 - PMCID: PMC6004069 - DOI: 10.1101/gad.311514.118

  • Mojarro A, Hachey J, Ruvkun G, Zuber MT, Carr CE CarrierSeq: a sequence analysis workflow for low-input nanopore sequencing. BMC Bioinformatics. 2018;19(1):108 - PMID: 29587645 - PMCID: PMC5872496 - DOI: 10.1186/s12859-018-2124-3

  • Pontefract A, Zhu TF, Walker VK, Hepburn H, Lui C, Zuber MT, Ruvkun G, Carr CE Microbial Diversity in a Hypersaline Sulfate Lake: A Terrestrial Analog of Ancient Mars. Front Microbiol. 2017;8:1819 - PMID: 29018418 - PMCID: PMC5623196 - DOI: 10.3389/fmicb.2017.01819

  • Mojarro A, Ruvkun G, Zuber MT, Carr CE Nucleic Acid Extraction from Synthetic Mars Analog Soils for in situ Life Detection. Astrobiology. 2017;17(8):747-760 - PMID: 28704064 - PMCID: PMC5567878 - DOI: 10.1089/ast.2016.1535

  • Lehrbach NJ, Ruvkun G Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1. Elife. 2016;5:ePub - PMID: 27528192 - PMCID: PMC4987142 - DOI: 10.7554/eLife.17721

  • Dowen RH, Breen PC, Tullius T, Conery AL, Ruvkun G A microRNA program in the C. elegans hypodermis couples to intestinal mTORC2/PQM-1 signaling to modulate fat transport. Genes Dev. 2016;30(13):1515-28 - PMID: 27401555 - PMCID: PMC4949325 - DOI: 10.1101/gad.283895.116

  • Samuel BS, Rowedder H, Braendle C, Félix MA, Ruvkun G Caenorhabditis elegans responses to bacteria from its natural habitats. Proc Natl Acad Sci U S A. 2016;113(27):E3941-9 - PMID: 27317746 - PMCID: PMC4941482 - DOI: 10.1073/pnas.1607183113

  • Rettberg P, Anesio AM, Baker VR, Baross JA, Cady SL, Detsis E, Foreman CM, Hauber E, Ori GG, Pearce DA, Renno NO, Ruvkun G, Sattler B, Saunders MP, Smith DH, Wagner D, Westall F Planetary Protection and Mars Special Regions-A Suggestion for Updating the Definition. Astrobiology. 2016;16(2):119-25 - PMID: 26848950 - DOI: 10.1089/ast.2016.1472

  • Govindan JA, Jayamani E, Zhang X, Mylonakis E, Ruvkun G Dialogue between E. coli free radical pathways and the mitochondria of C. elegans. Proc Natl Acad Sci U S A. 2015;112(40):12456-61 - PMID: 26392561 - PMCID: PMC4603447 - DOI: 10.1073/pnas.1517448112

  • Govindan JA, Jayamani E, Zhang X, Breen P, Larkins-Ford J, Mylonakis E, Ruvkun G Lipid signalling couples translational surveillance to systemic detoxification in Caenorhabditis elegans. Nat Cell Biol. 2015;17(10):1294-303 - PMID: 26322678 - PMCID: PMC4589496 - DOI: 10.1038/ncb3229

  • Phillips CM, Brown KC, Montgomery BE, Ruvkun G, Montgomery TA piRNAs and piRNA-Dependent siRNAs Protect Conserved and Essential C. elegans Genes from Misrouting into the RNAi Pathway. Dev Cell. 2015;34(4):457-465 - PMID: 26279487 - PMCID: PMC4550515 - DOI: 10.1016/j.devcel.2015.07.009

  • Sadreyev IR, Ji F, Cohen E, Ruvkun G, Tabach Y PhyloGene server for identification and visualization of co-evolving proteins using normalized phylogenetic profiles. Nucleic Acids Res. 2015;43(W1):W154-W159 - PMID: 25958392 - PMCID: PMC4489270 - DOI: 10.1093/nar/gkv452

  • Kirienko NV, Ausubel FM, Ruvkun G Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 2015;112(6):1821-6 - PMID: 25624506 - PMCID: PMC4330731 - DOI: 10.1073/pnas.1424954112

  • Wang MC, Oakley HD, Carr CE, Sowa JN, Ruvkun G Gene Pathways That Delay Caenorhabditis elegans Reproductive Senescence. PLoS Genet. 2014;10(12):e1004752 - PMID: 25474471 - PMCID: PMC4256158 - DOI: 10.1371/journal.pgen.1004752

  • O'Rourke EJ, Ruvkun G Corrigendum: MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability. Nat Cell Biol. 2014;17(1):104 - PMID: 25534088

  • Govindan JA, Ruvkun G Pathogens. Virulence. 2014;5(7):ePub - PMID: 25290904 - PMCID: PMC4189874

  • Govindan JA, Ruvkun G Pathogens. Virulence. 2014;5(7):695-696 - PMID: 25513769 - PMCID: PMC4189874 - DOI: 10.4161/viru.36667

  • Garcia SM, Tabach Y, Lourenço GF, Armakola M, Ruvkun G Identification of genes in toxicity pathways of trinucleotide-repeat RNA in C. elegans. Nat Struct Mol Biol. 2014;21(8):712-720 - PMID: 25038802 - PMCID: PMC4125460 - DOI: 10.1038/nsmb.2858

  • Liu Y, Samuel BS, Breen PC, Ruvkun G Caenorhabditis elegans pathways that surveil and defend mitochondria. Nature. 2014;508(7496):406-10 - PMID: 24695221 - PMCID: PMC4102179 - DOI: 10.1038/nature13204

  • Phillips CM, Montgomery BE, Breen PC, Roovers EF, Rim YS, Ohsumi TK, Newman MA, van Wolfswinkel JC, Ketting RF, Ruvkun G, Montgomery TA MUT-14 and SMUT-1 DEAD Box RNA Helicases Have Overlapping Roles in Germline RNAi and Endogenous siRNA Formation. Curr Biol. 2014;24(8):839-44 - PMID: 24684932 - PMCID: PMC4010136 - DOI: 10.1016/j.cub.2014.02.060

  • Fischer SE, Pan Q, Breen PC, Qi Y, Shi Z, Zhang C, Ruvkun G Multiple small RNA pathways regulate the silencing of repeated and foreign genes in C. elegans. Genes Dev. 2013;27(24):2678-95 - PMID: 24352423 - PMCID: PMC3877757 - DOI: 10.1101/gad.233254.113

  • Schwartz S, Agarwala SD, Mumbach MR, Jovanovic M, Mertins P, Shishkin A, Tabach Y, Mikkelsen TS, Satija R, Ruvkun G, Carr SA, Lander ES, Fink GR, Regev A High-Resolution Mapping Reveals a Conserved, Widespread, Dynamic mRNA Methylation Program in Yeast Meiosis. Cell. 2013;155(6):1409-21 - PMID: 24269006 - PMCID: PMC3956118 - DOI: 10.1016/j.cell.2013.10.047

  • Soukas AA, Carr CE, Ruvkun G Genetic Regulation of Caenorhabditis elegans Lysosome Related Organelle Function. PLoS Genet. 2013;9(10):e1003908 - PMID: 24204312 - PMCID: PMC3812091 - DOI: 10.1371/journal.pgen.1003908

  • Tabach Y, Golan T, Hernández-Hernández A, Messer AR, Fukuda T, Kouznetsova A, Liu JG, Lilienthal I, Levy C, Ruvkun G Human disease locus discovery and mapping to molecular pathways through phylogenetic profiling. Mol Syst Biol. 2013;9:692 - PMID: 24084807 - PMCID: PMC3817400 - DOI: 10.1038/msb.2013.50

  • Shi Z, Hayes G, Ruvkun G Dual Regulation of the lin-14 Target mRNA by the lin-4 miRNA. PLoS One. 2013;8(9):e75475 - PMID: 24058689 - PMCID: PMC3772890 - DOI: 10.1371/journal.pone.0075475

  • Carr CE, Rowedder H, Lui CS, Zlatkovsky I, Papalias CW, Bolander J, Myers JW, Bustillo J, Rothberg JM, Zuber MT, Ruvkun G Radiation Resistance of Sequencing Chips for in situ Life Detection. Astrobiology. 2013;13(6):560-9 - PMID: 23734755 - DOI: 10.1089/ast.2012.0923

  • Shore DE, Ruvkun G A cytoprotective perspective on longevity regulation. Trends Cell Biol. 2013;23(9):409-20 - PMID: 23726168 - PMCID: PMC4057428 - DOI: 10.1016/j.tcb.2013.04.007

  • O'Rourke EJ, Ruvkun G MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability. Nat Cell Biol. 2013;15(6):668-676 - PMID: 23604316 - PMCID: PMC3723461 - DOI: 10.1038/ncb2741

  • Riedel CG, Dowen RH, Lourenco GF, Kirienko NV, Heimbucher T, West JA, Bowman SK, Kingston RE, Dillin A, Asara JM, Ruvkun G DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity. Nat Cell Biol. 2013;15(5):491-501 - PMID: 23604319 - PMCID: PMC3748955 - DOI: 10.1038/ncb2720

  • Kirienko NV, Kirienko DR, Larkins-Ford J, Wählby C, Ruvkun G, Ausubel FM Pseudomonas aeruginosa Disrupts Caenorhabditis elegans Iron Homeostasis, Causing a Hypoxic Response and Death. Cell Host Microbe. 2013;13(4):406-16 - PMID: 23601103 - PMCID: PMC3641844 - DOI: 10.1016/j.chom.2013.03.003

  • Kirienko NV, Kirienko DR, Larkins-Ford J, Wählby C, Ruvkun G, Ausubel FM Pseudomonas aeruginosa Disrupts Caenorhabditis elegans Iron Homeostasis, Causing a Hypoxic Response and Death. Cell Host Microbe. 2013;13(4):406-16 - PMID: 23601103 - PMCID: PMC3641844 - DOI: 10.1016/j.chom.2013.03.003

  • Montgomery TA, Ruvkun G MicroRNAs Visit the ER. Cell. 2013;153(3):511-2 - PMID: 23622236 - DOI: 10.1016/j.cell.2013.04.014

  • O'Rourke EJ, Kuballa P, Xavier R, Ruvkun G ?-6 Polyunsaturated fatty acids extend life span through the activation of autophagy. Genes Dev. 2013;27(4):429-40 - PMID: 23392608 - PMCID: PMC3589559 - DOI: 10.1101/gad.205294.112

  • Shi Z, Montgomery TA, Qi Y, Ruvkun G High-throughput sequencing reveals extraordinary fluidity of miRNA, piRNA, and siRNA pathways in nematodes. Genome Res. 2013;23(3):497-508 - PMID: 23363624 - PMCID: PMC3589538 - DOI: 10.1101/gr.149112.112

  • Carr CE, Rowedder H, Vafadari C, Lui CS, Cascio E, Zuber MT, Ruvkun G Radiation resistance of biological reagents for in situ life detection. Astrobiology. 2013;13(1):68-78 - PMID: 23330963 - DOI: 10.1089/ast.2012.0869

  • Tabach Y, Billi AC, Hayes GD, Newman MA, Zuk O, Gabel H, Kamath R, Yacoby K, Chapman B, Garcia SM, Borowsky M, Kim JK, Ruvkun G Identification of small RNA pathway genes using patterns of phylogenetic conservation and divergence. Nature. 2013;493(7434):694-8 - PMID: 23364702 - PMCID: PMC3762460 - DOI: 10.1038/nature11779

  • Tacutu R, Shore DE, Budovsky A, de Magalhães JP, Ruvkun G, Fraifeld VE, Curran SP Prediction of C. elegans Longevity Genes by Human and Worm Longevity Networks. PLoS One. 2012;7(10):e48282 - PMID: 23144747 - PMCID: PMC3483217 - DOI: 10.1371/journal.pone.0048282

  • Zhang C, Ruvkun G New insights into siRNA amplification and RNAi. RNA Biol. 2012;9(8):1045-9 - PMID: 22858672 - PMCID: PMC3551858 - DOI: 10.4161/rna.21246

  • Shore DE, Carr CE, Ruvkun G Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways. PLoS Genet. 2012;8(7):e1002792 - PMID: 22829775 - PMCID: PMC3400582 - DOI: 10.1371/journal.pgen.1002792

  • Phillips CM, Montgomery TA, Breen PC, Ruvkun G MUT-16 promotes formation of perinuclear Mutator foci required for RNA silencing in the C. elegans germline. Genes Dev. 2012;26(13):1433-44 - PMID: 22713602 - PMCID: PMC3403012 - DOI: 10.1101/gad.193904.112

  • Zhang C, Montgomery TA, Fischer SE, Garcia SM, Riedel CG, Fahlgren N, Sullivan CM, Carrington JC, Ruvkun G The Caenorhabditis elegans RDE-10/RDE-11 Complex Regulates RNAi by Promoting Secondary siRNA Amplification. Curr Biol. 2012;22(10):881-90 - PMID: 22542102 - PMCID: PMC3371361 - DOI: 10.1016/j.cub.2012.04.011

  • Wählby C, Kamentsky L, Liu ZH, Riklin-Raviv T, Conery AL, O'Rourke EJ, Sokolnicki KL, Visvikis O, Ljosa V, Irazoqui JE, Golland P, Ruvkun G, Ausubel FM, Carpenter AE An image analysis toolbox for high-throughput C. elegans assays. Nat Methods. 2012;9(7):714-6 - PMID: 22522656 - PMCID: PMC3433711 - DOI: 10.1038/nmeth.1984

  • Montgomery TA, Rim YS, Zhang C, Dowen RH, Phillips CM, Fischer SE, Ruvkun G PIWI Associated siRNAs and piRNAs Specifically Require the Caenorhabditis elegans HEN1 Ortholog henn-1. PLoS Genet. 2012;8(4):e1002616 - PMID: 22536158 - PMCID: PMC3334881 - DOI: 10.1371/journal.pgen.1002616

  • Melo JA, Ruvkun G Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses. Cell. 2012;149(2):452-66 - PMID: 22500807 - PMCID: PMC3613046 - DOI: 10.1016/j.cell.2012.02.050

  • Wu X, Shi Z, Cui M, Han M, Ruvkun G Repression of Germline RNAi Pathways in Somatic Cells by Retinoblastoma Pathway Chromatin Complexes. PLoS Genet. 2012;8(3):e1002542 - PMID: 22412383 - PMCID: PMC3297578 - DOI: 10.1371/journal.pgen.1002542

  • Shi Z, Ruvkun G The mevalonate pathway regulates microRNA activity in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2012;109(12):4568-73 - PMID: 22396595 - PMCID: PMC3311396 - DOI: 10.1073/pnas.1202421109

  • Kimura KD, Riddle DL, Ruvkun G The C. elegans DAF-2 Insulin-Like Receptor is Abundantly Expressed in the Nervous System and Regulated by Nutritional Status. Cold Spring Harb Symp Quant Biol. 2011;76:113-20 - PMID: 22123849 - DOI: 10.1101/sqb.2011.76.010660

  • Fischer SE, Montgomery TA, Zhang C, Fahlgren N, Breen PC, Hwang A, Sullivan CM, Carrington JC, Ruvkun G The ERI-6/7 helicase acts at the first stage of an siRNA amplification pathway that targets recent gene duplications. PLoS Genet. 2011;7(11):e1002369 - PMID: 22102828 - PMCID: PMC3213143 - DOI: 10.1371/journal.pgen.1002369

  • Russel S, Frand AR, Ruvkun G Regulation of the C. elegans molt by pqn-47. Dev Biol. 2011;360(2):297-309 - PMID: 21989027 - PMCID: PMC3618673 - DOI: 10.1016/j.ydbio.2011.09.025

  • Hayes GD, Riedel CG, Ruvkun G The Caenorhabditis elegans SOMI-1 zinc finger protein and SWI/SNF promote regulation of development by the mir-84 microRNA. Genes Dev. 2011;25(19):2079-92 - PMID: 21979920 - PMCID: PMC3197206 - DOI: 10.1101/gad.17153811

  • Zhang C, Montgomery TA, Gabel HW, Fischer SE, Phillips CM, Fahlgren N, Sullivan CM, Carrington JC, Ruvkun G mut-16 and other mutator class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2011;108(4):1201-8 - PMID: 21245313 - PMCID: PMC3029761 - DOI: 10.1073/pnas.1018695108

  • Wang MC, Min W, Freudiger CW, Ruvkun G, Xie XS RNAi screening for fat regulatory genes with SRS microscopy. Nat Methods. 2011;8(2):135-8 - PMID: 21240281 - PMCID: PMC3061290 - DOI: 10.1038/nmeth.1556

  • Wu X, Ruvkun G Cancer. Germ cell genes and cancer. Science. 2010;330(6012):1761-2 - PMID: 21205660 - DOI: 10.1126/science.1200772

  • Meli VS, Osuna B, Ruvkun G, Frand AR MLT-10 defines a family of DUF644 and proline-rich repeat proteins involved in the molting cycle of Caenorhabditis elegans. Mol Biol Cell. 2010;21(10):1648-61 - PMID: 20335506 - PMCID: PMC2869372 - DOI: 10.1091/mbc.E08-07-0708

  • Sebastiani P, Montano M, Puca A, Solovieff N, Kojima T, Wang MC, Melista E, Meltzer M, Fischer SE, Andersen S, Hartley SH, Sedgewick A, Arai Y, Bergman A, Barzilai N, Terry DF, Riva A, Anselmi CV, Malovini A, Kitamoto A, Sawabe M, Arai T, Gondo Y, Steinberg MH, Hirose N, Atzmon G, Ruvkun G, Baldwin CT, Perls TT RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans. PLoS One. 2009;4(12):e8210 - PMID: 20011587 - PMCID: PMC2788130 - DOI: 10.1371/journal.pone.0008210

  • O'Rourke EJ, Soukas AA, Carr CE, Ruvkun G C. elegans major fats are stored in vesicles distinct from lysosome-related organelles. Cell Metab. 2009;10(5):430-5 - PMID: 19883620 - PMCID: PMC2921818 - DOI: 10.1016/j.cmet.2009.10.002

  • Curran SP, Wu X, Riedel CG, Ruvkun G A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants. Nature. 2009;459(7250):1079-84 - PMID: 19506556 - PMCID: PMC2716045 - DOI: 10.1038/nature08106

  • Soukas AA, Kane EA, Carr CE, Melo JA, Ruvkun G Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans. Genes Dev. 2009;23(4):496-511 - PMID: 19240135 - PMCID: PMC2648650 - DOI: 10.1101/gad.1775409

  • Butcher RA, Ragains JR, Li W, Ruvkun G, Clardy J, Mak HY Biosynthesis of the Caenorhabditis elegans dauer pheromone. Proc Natl Acad Sci U S A. 2009;106(6):1875-9 - PMID: 19174521 - PMCID: PMC2631283 - DOI: 10.1073/pnas.0810338106

  • Wang MC, O'Rourke EJ, Ruvkun G Fat metabolism links germline stem cells and longevity in C. elegans. Science. 2008;322(5903):957-60 - PMID: 18988854 - PMCID: PMC2760269 - DOI: 10.1126/science.1162011

  • Isenbarger TA, Carr CE, Johnson SS, Finney M, Church GM, Gilbert W, Zuber MT, Ruvkun G The most conserved genome segments for life detection on Earth and other planets. Orig Life Evol Biosph. 2008;38(6):517-33 - PMID: 18853276 - DOI: 10.1007/s11084-008-9148-z

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  • Curran SP, Ruvkun G Lifespan regulation by evolutionarily conserved genes essential for viability. PLoS Genet. 2007;3(4):e56 - PMID: 17411345 - PMCID: PMC1847696 - DOI: 10.1371/journal.pgen.0030056

  • Hayes GD, Frand AR, Ruvkun G The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25. Development. 2006;133(23):4631-41 - PMID: 17065234 - DOI: 10.1242/dev.02655

  • Hu PJ, Xu J, Ruvkun G Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling. PLoS Genet. 2006;2(7):e99 - PMID: 16839187 - PMCID: PMC1487177 - DOI: 10.1371/journal.pgen.0020099

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  • Kim JK, Gabel HW, Kamath RS, Tewari M, Pasquinelli A, Rual JF, Kennedy S, Dybbs M, Bertin N, Kaplan JM, Vidal M, Ruvkun G Functional genomic analysis of RNA interference in C. elegans. Science. 2005;308(5725):1164-7 - PMID: 15790806 - DOI: 10.1126/science.1109267

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  • Mak HY, Ruvkun G Intercellular signaling of reproductive development by the C. elegans DAF-9 cytochrome P450. Development. 2004;131(8):1777-86 - PMID: 15084462 - DOI: 10.1242/dev.01069

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  • Komaroff AL, Ruvkun G Unraveling the secrets of the cell. Newsweek. 2003;142(23):96 - PMID: 14712576

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  • Aspöck G, Ruvkun G, Bürglin TR The Caenorhabditis elegans ems class homeobox gene ceh-2 is required for M3 pharynx motoneuron function. Development. 2003;130(15):3369-78 - PMID: 12810585 - DOI: 10.1242/dev.00551

  • Sze JY, Ruvkun G Activity of the Caenorhabditis elegans UNC-86 POU transcription factor modulates olfactory sensitivity. Proc Natl Acad Sci U S A. 2003;100(16):9560-5 - PMID: 12883006 - PMCID: PMC170957 - DOI: 10.1073/pnas.1530752100

  • Bashirullah A, Pasquinelli AE, Kiger AA, Perrimon N, Ruvkun G, Thummel CS Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis. Dev Biol. 2003;259(1):1-8 - PMID: 12812783 - DOI: 10.1016/s0012-1606(03)00063-0

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  • Garsin DA, Villanueva JM, Begun J, Kim DH, Sifri CD, Calderwood SB, Ruvkun G, Ausubel FM Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens. Science. 2003;300(5627):1921 - PMID: 12817143 - DOI: 10.1126/science.1080147

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  • Sze JY, Zhang S, Li J, Ruvkun G The C. elegans POU-domain transcription factor UNC-86 regulates the tph-1 tryptophan hydroxylase gene and neurite outgrowth in specific serotonergic neurons. Development. 2002;129(16):3901-11 - PMID: 12135927 - DOI: 10.1242/dev.129.16.3901

  • Lee SS, Ruvkun G Longevity: don't hold your breath. Nature. 2002;418(6895):287-8 - PMID: 12124610 - DOI: 10.1038/418287a

  • Pasquinelli AE, Ruvkun G Control of developmental timing by micrornas and their targets. Annu Rev Cell Dev Biol. 2002;18:495-513 - PMID: 12142272 - DOI: 10.1146/annurev.cellbio.18.012502.105832

  • Lee RY, Hench J, Ruvkun G Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway. Curr Biol. 2001;11(24):1950-7 - PMID: 11747821 - DOI: 10.1016/s0960-9822(01)00595-4

  • Finch CE, Ruvkun G The genetics of aging. Annu Rev Genomics Hum Genet. 2001;2:435-62 - PMID: 11701657 - DOI: 10.1146/annurev.genom.2.1.435

  • Ruvkun G Molecular biology. Glimpses of a tiny RNA world. Science. 2001;294(5543):797-9 - PMID: 11679654 - DOI: 10.1126/science.1066315

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  • Pierce SB, Costa M, Wisotzkey R, Devadhar S, Homburger SA, Buchman AR, Ferguson KC, Heller J, Platt DM, Pasquinelli AA, Liu LX, Doberstein SK, Ruvkun G Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family. Genes Dev. 2001;15(6):672-86 - PMID: 11274053 - PMCID: PMC312654 - DOI: 10.1101/gad.867301

  • Bürglin TR, Ruvkun G Regulation of ectodermal and excretory function by the C. elegans POU homeobox gene ceh-6. Development. 2001;128(5):779-90 - PMID: 11171402 - DOI: 10.1242/dev.128.5.779

  • Reinhart BJ, Ruvkun G Isoform-specific mutations in the Caenorhabditis elegans heterochronic gene lin-14 affect stage-specific patterning. Genetics. 2001;157(1):199-209 - PMID: 11139502 - PMCID: PMC1461488 - DOI: 10.1093/genetics/157.1.199

  • Kagoshima H, Sommer R, Reinhart BJ, Cassata G, Ruvkun G, Bürglin TR Graded expression of ceh-14 reporters in the hypodermis is induced by a gonadal signal. Dev Genes Evol. 2000;210(11):564-9 - PMID: 11180807 - DOI: 10.1007/s004270000099

  • Pasquinelli AE, Reinhart BJ, Slack F, Martindale MQ, Kuroda MI, Maller B, Hayward DC, Ball EE, Degnan B, Müller P, Spring J, Srinivasan A, Fishman M, Finnerty J, Corbo J, Levine M, Leahy P, Davidson E, Ruvkun G Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature. 2000;408(6808):86-9 - PMID: 11081512 - DOI: 10.1038/35040556

  • Wolkow CA, Kimura KD, Lee MS, Ruvkun G Regulation of C. elegans life-span by insulinlike signaling in the nervous system. Science. 2000;290(5489):147-50 - PMID: 11021802 - DOI: 10.1126/science.290.5489.147

  • Nasrin N, Ogg S, Cahill CM, Biggs W, Nui S, Dore J, Calvo D, Shi Y, Ruvkun G, Alexander-Bridges MC DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells. Proc Natl Acad Sci U S A. 2000;97(19):10412-7 - PMID: 10973497 - PMCID: PMC27038 - DOI: 10.1073/pnas.190326997

  • Slack FJ, Basson M, Liu Z, Ambros V, Horvitz HR, Ruvkun G The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor. Mol Cell. 2000;5(4):659-69 - PMID: 10882102 - DOI: 10.1016/s1097-2765(00)80245-2

  • Reinhart BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC, Rougvie AE, Horvitz HR, Ruvkun G The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature. 2000;403(6772):901-6 - PMID: 10706289 - DOI: 10.1038/35002607

  • Sze JY, Victor M, Loer C, Shi Y, Ruvkun G Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant. Nature. 2000;403(6769):560-4 - PMID: 10676966 - DOI: 10.1038/35000609

  • Tissenbaum HA, Hawdon J, Perregaux M, Hotez P, Guarente L, Ruvkun G A common muscarinic pathway for diapause recovery in the distantly related nematode species Caenorhabditis elegans and Ancylostoma caninum. Proc Natl Acad Sci U S A. 2000;97(1):460-5 - PMID: 10618440 - PMCID: PMC26685 - DOI: 10.1073/pnas.97.1.460

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  • Sagasti A, Hobert O, Troemel ER, Ruvkun G, Bargmann CI Alternative olfactory neuron fates are specified by the LIM homeobox gene lim-4. Genes Dev. 1999;13(14):1794-806 - PMID: 10421632 - PMCID: PMC316880 - DOI: 10.1101/gad.13.14.1794

  • Paradis S, Ailion M, Toker A, Thomas JH, Ruvkun G A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans. Genes Dev. 1999;13(11):1438-52 - PMID: 10364160 - PMCID: PMC316759 - DOI: 10.1101/gad.13.11.1438

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  • Hobert O, Tessmar K, Ruvkun G The Caenorhabditis elegans lim-6 LIM homeobox gene regulates neurite outgrowth and function of particular GABAergic neurons. Development. 1999;126(7):1547-62 - PMID: 10068647 - DOI: 10.1242/dev.126.7.1547

  • Hobert O, Moerman DG, Clark KA, Beckerle MC, Ruvkun G A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans. J Cell Biol. 1999;144(1):45-57 - PMID: 9885243 - PMCID: PMC2148118 - DOI: 10.1083/jcb.144.1.45

  • Hobert O, Ruvkun G A common theme for LIM homeobox gene function across phylogeny?. Biol Bull. 1998;195(3):377-80 - PMID: 9924780 - DOI: 10.2307/1543153

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  • Ruvkun G, Hobert O The taxonomy of developmental control in Caenorhabditis elegans. Science. 1998;282(5396):2033-41 - PMID: 9851920 - DOI: 10.1126/science.282.5396.2033

  • Guarente L, Ruvkun G, Amasino R Aging, life span, and senescence. Proc Natl Acad Sci U S A. 1998;95(19):11034-6 - PMID: 9736682 - PMCID: PMC33892 - DOI: 10.1073/pnas.95.19.11034

  • Paradis S, Ruvkun G Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes Dev. 1998;12(16):2488-98 - PMID: 9716402 - PMCID: PMC317081 - DOI: 10.1101/gad.12.16.2488

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  • Patterson GI, Koweek A, Wong A, Liu Y, Ruvkun G The DAF-3 Smad protein antagonizes TGF-beta-related receptor signaling in the Caenorhabditis elegans dauer pathway. Genes Dev. 1997;11(20):2679-90 - PMID: 9334330 - PMCID: PMC316611 - DOI: 10.1101/gad.11.20.2679

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  • Hobert O, Mori I, Yamashita Y, Honda H, Ohshima Y, Liu Y, Ruvkun G Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 LIM homeobox gene. Neuron. 1997;19(2):345-57 - PMID: 9292724 - DOI: 10.1016/s0896-6273(00)80944-7

  • Sluder AE, Lindblom T, Ruvkun G The Caenorhabditis elegans orphan nuclear hormone receptor gene nhr-2 functions in early embryonic development. Dev Biol. 1997;184(2):303-19 - PMID: 9133437 - DOI: 10.1006/dbio.1997.8544

  • Sze JY, Liu Y, Ruvkun G VP16-activation of the C. elegans neural specification transcription factor UNC-86 suppresses mutations in downstream genes and causes defects in neural migration and axon outgrowth. Development. 1997;124(6):1159-68 - PMID: 9102303 - DOI: 10.1242/dev.124.6.1159

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  • Morris JZ, Tissenbaum HA, Ruvkun G A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature. 1996;382(6591):536-9 - PMID: 8700226 - DOI: 10.1038/382536a0

  • Barnes TM, Jin Y, Horvitz HR, Ruvkun G, Hekimi S The Caenorhabditis elegans behavioral gene unc-24 encodes a novel bipartite protein similar to both erythrocyte band 7.2 (stomatin) and nonspecific lipid transfer protein. J Neurochem. 1996;67(1):46-57 - PMID: 8667025 - DOI: 10.1046/j.1471-4159.1996.67010046.x

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