Directed protein evolution is a powerful tool to identify and improve the biological function of protein molecules, and display technologies have been very successful in selecting individual molecules with the desired function from diverse, modified populations. We are developing new display technologies to efficiently conduct protein evolution as well as working with current RNA display techniques. Our focus is on the identification of novel high-affinity and highly specific target binding proteins (such as antibodies or antibody mimics) with therapeutically useful biological functions as well as other application of improving biological function through protein engineering. The specific target proteins are identified after extensive literature evaluation and discussion with thought leaders, and candidate target binding proteins will be produced and used in relevant animal models to evaluate efficacy.